TWAS hub - PLCB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.095	0.033	6.6e-07	0.03	0.061	0.077	0.064	0.062	1.2e-04	5.8e-08	1.1e-09	3e-08	5.3e-08
2	GTEx	Esophagus Mucosa	0.276	0.061	2.8e-13	0.24	NA	0.213	NA	0.234	3.9e-16	NA	2.9e-14	NA	1.1e-15

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Gout (self-reported)	10.3	14.1	21.9	4.7	-2.5
Osteoporosis (self-reported)	9.9	12.3	12.5	3.5	-3.5
Supplements: Calcium	9.6	10.6	10.8	3.2	-3.3
Fed-up feelings	9.3	16.8	18.0	4.2	-4.0
Taking other prescription medications	8.6	13.2	14.8	3.9	-3.4
Vitamin and mineral supplements	8.3	11.3	13.3	-3.6	3.0
Alcohol intake versus 10 years previously	8.0	11.9	14.1	3.1	-3.8
Medication: Allopurinol	7.8	10.4	13.0	3.6	-2.8
Mood swings	7.1	12.9	15.2	3.9	-3.3
Smoking Status	6.6	15.7	20.9	4.6	-3.2
Hip circumference	6.5	28.2	41.7	-3.8	6.5
Hypothyroidism (self reported)	6.4	14.7	16.0	3.6	-4.0
Ever smoked	6.2	10.9	13.4	3.7	-2.9
BMI	5.7	33.3	48.0	-4.3	6.9
Multivitamins +/- minerals	5.7	7.2	9.4	3.1	-2.2
Crohns Disease (2012)	5.3	8.5	13.5	3.7	-1.9
Blood Platelet Count	5.3	60.9	114.5	-2.7	10.7
Qualifications: nursing, teaching	5.2	8.0	9.1	-2.7	3.0
Arm fat mass (left)	5.2	21.2	34.9	-2.7	5.9
Ever had prostate specific antigen (PSA) test	5.2	6.0	8.0	2.8	-2.0
Crohns Disease (2017)	5.0	11.0	16.7	4.1	-2.3
Arm fat mass (right)	5.0	20.8	34.3	-2.7	5.9
Basal cell carcinoma (self-reported)	5.0	5.9	6.2	-2.4	2.5
Depressed Affect (Nagel 2018)	4.8	10.1	11.8	3.4	-2.9
Miserableness	4.7	8.2	8.5	2.9	-2.8
Primary Biliary Cirrhosis	4.6	6.6	7.4	2.4	-2.7
Qualifications: College or University degree	4.6	14.4	15.2	-3.9	3.7
Rheumatoid Arthritis	4.4	6.1	7.2	2.7	-2.2
Alcohol drinker status: Never	4.4	5.3	5.5	-2.4	2.2
Arm fat percentage (right)	4.3	16.9	28.6	-2.3	5.3
Hypothyroidism/myxoedema (self-reported)	4.3	8.5	9.9	3.1	-2.7
Arm fat percentage (left)	4.3	17.3	28.8	-2.4	5.4
Schizophrenia (2018)	4.0	8.3	10.5	2.5	-3.2
Maternal smoking around birth	4.0	5.7	6.7	2.6	-2.2
Pulse wave peak to peak time	4.0	4.7	5.3	-2.3	2.0
Prospective memory result	3.9	4.7	5.5	2.3	-2.0
Whole body fat mass	3.9	16.4	27.4	-2.4	5.2
Neuroticism	3.8	9.2	12.9	3.6	-2.3
Trunk fat percentage	3.8	15.1	26.6	-1.9	5.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	10.4	3.2	-1.1
Mean time to correctly identify matches	3.8	7.2	14.3	-0.3	-3.8
Pulse rate, automated reading	3.8	12.4	21.0	-1.9	4.6
Neuroticism (Nagel 2018)	3.7	8.8	12.9	3.6	-2.2
Reaction Time	3.7	7.0	13.7	-0.6	-3.7
Body mass index (BMI)	3.7	15.6	26.3	-2.2	5.1
Trunk fat mass	3.7	15.9	27.0	-2.2	5.2
Pulse wave Arterial Stiffness index	3.7	4.3	4.7	2.2	-2.0
Bipolar Disorder or Schizophrenia	3.6	8.7	10.0	2.7	-3.2
Illness, injury, bereavement, stress in last 2 years	3.6	4.4	5.1	-2.3	1.9
Verbal and Numeric Reasoning (VNR)	3.5	8.4	9.0	-3.0	2.8
Neuroticism (2016)	3.5	5.0	9.3	3.0	-0.8
Diabetes (father)	3.5	4.4	4.6	-2.0	2.1
Weight	3.5	17.3	27.8	-2.6	5.3
Body fat percentage	3.5	14.0	24.7	-1.8	5.0
Fractured/broken bones in last 5 years	3.5	4.5	5.3	2.3	-1.9
Irritable Bowel Disease (IBD)	3.4	8.1	12.2	3.5	-2.0
Waist Hip Ratio (WHR)	3.4	15.4	23.0	2.8	-4.8
Number of treatments/medications taken	3.4	6.0	6.2	2.5	-2.4
Neuroticism score	3.4	7.1	9.8	3.1	-2.1
Number of self-reported non-cancer illnesses	3.4	5.8	6.1	2.4	-2.5
Heel T-Score	3.2	25.1	33.5	-4.1	5.8
Medication: Levothyroxine sodium	3.2	5.4	5.8	2.2	-2.4
Tense / ‘highly strung’	3.2	5.3	8.0	2.8	-1.6
Leg fat mass (right)	3.2	12.3	20.5	-2.0	4.5
Past tobacco smoking	3.1	5.7	8.6	-2.9	1.7
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.0	7.8	-2.5	2.8
High cholesterol (Self-reported)	3.1	5.6	9.0	3.0	-1.5
Leg fat mass (left)	3.1	12.1	20.8	-1.9	4.6
Intelligence (Savage-Jansen 2018)	3.0	9.3	9.8	-3.0	3.1
Schizophrenia (2014)	3.0	6.6	8.0	2.3	-2.8
Fluid intelligence score	3.0	6.3	6.6	-2.6	2.5
Body Mass Index (BMI) (2010)	2.9	4.0	6.5	-1.2	2.5
Length of working week for main job	2.9	3.2	3.7	-1.9	1.7
Hearing aid user	2.9	3.3	3.5	1.9	-1.8
Number of operations (self-reported)	2.9	4.3	5.4	-1.8	2.3
Major Depression (MDD)	2.8	3.4	6.8	2.6	0.0
Ulcerative Colitis	2.7	3.9	5.2	2.3	-1.6
Nervous feelings	2.7	5.1	7.5	2.7	-1.6
Supplements: Zinc	2.6	2.8	4.4	1.1	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	7.9	2.8	-0.4
Relative age voice broke	2.5	3.9	7.6	2.8	-0.4
Leg predicted mass (left)	2.5	13.5	20.5	-2.5	4.5
Number of live births	2.5	3.5	6.8	2.6	0.5
Depression (self-reported)	2.5	3.0	5.7	2.4	-0.6
Ever highly irritable/argumentative for 2 days	2.5	3.0	4.8	2.2	-1.1
Leg pain on walking	2.5	3.2	4.1	-2.0	1.5
Smoking status: Previous	2.5	3.8	5.6	2.4	-1.4
Bipolar Disorder (2011)	2.4	2.3	3.4	1.1	-1.8
Leg fat-free mass (left)	2.4	12.8	19.6	-2.5	4.4
Waist circumference	2.4	8.9	14.1	-1.9	3.8
Leg fat percentage (right)	2.4	8.8	14.9	-1.6	3.9
Illnesses of father: Heart disease	2.4	3.3	5.6	1.0	-2.4
Ovarian Cancer	2.3	3.0	4.2	2.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	6.2	-2.5	2.0
Qualifications: None of the above	2.3	4.9	6.3	2.5	-1.9
Pulse rate	2.2	3.6	7.2	-0.3	2.7
Qualifications: A levels/AS levels or equivalent	2.2	4.8	6.2	-2.5	1.8
Leg fat percentage (left)	2.2	7.9	13.9	-1.4	3.7
Number of incorrect matches in round	2.1	3.5	6.8	0.5	-2.6
Pulse wave reflection index	2.1	2.5	4.6	0.7	-2.2
Asthma (self-reported)	2.1	4.2	6.4	-1.4	2.5
Illnesses of father: None of the above (group 1)	2.1	2.6	5.2	-0.2	2.3
Myopia	2.1	3.0	3.3	1.7	-1.8
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	3.8	-1.6	2.0
Leg fat-free mass (right)	2.0	10.6	16.4	-2.2	4.0
Long-standing illness, disability or infirmity	2.0	3.1	3.6	1.6	-1.9
Leg predicted mass (right)	2.0	10.4	16.2	-2.2	4.0
Basal metabolic rate	2.0	11.0	17.2	-2.2	4.2
Irritability	2.0	3.4	3.9	1.7	-2.0
Pain experienced in last month	2.0	3.3	5.3	-2.3	1.1
Diabetes (mother)	1.9	2.5	3.6	-1.1	1.9
Hearing difficulty/problems with background noise	1.9	3.0	4.9	2.2	-1.1
Ever depressed for a whole week	1.9	2.3	4.0	2.0	-0.8
Arm predicted mass (left)	1.9	9.4	14.6	-2.1	3.8
Cardiovascular Disease	1.8	6.1	8.5	2.9	-1.9
Ever had hysterectomy (womb removed)	1.8	2.0	2.2	-1.4	1.5
Financial difficulties in last 2 years	1.8	2.4	3.5	1.9	-1.1
Handedness (chirality/laterality): Left-handed	1.8	2.1	3.9	0.6	-2.0
Guilty feelings	1.8	2.6	5.1	2.3	-0.4
Arm fat-free mass (left)	1.8	9.1	14.1	-2.0	3.8
Depression (Nagel 2018)	1.7	2.6	2.9	1.7	-1.5
Asthma	1.7	3.4	5.8	-1.1	2.4
Medication: Amlodipine	1.7	2.3	3.3	1.8	-1.1
Average weekly red wine intake	1.7	2.5	4.0	-2.0	1.0
Illnesses of father: High blood pressure	1.7	2.1	3.8	0.7	-2.0
Lupus	1.6	2.3	2.6	1.5	-1.6
Medication: Co-codamol	1.6	1.9	2.5	1.1	1.6
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	2.8	1.5	-1.7
Medication: Atorvastatin	1.6	2.0	3.0	1.7	-1.1
Worry (Nagel 2018)	1.5	3.1	3.9	2.0	-1.5
Systolic Blood Pressure	1.5	7.7	13.6	1.3	-3.7
High blood pressure	1.5	4.3	5.4	2.3	-1.8
Back pain experienced in last month	1.5	2.1	4.2	2.0	0.3
Mother’s age at death	1.5	1.9	2.6	1.1	-1.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.8	0.1	1.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.6	-0.7	-1.6
Impedance of leg (left)	1.4	6.7	8.5	2.2	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.3	-0.2	1.8
Arm predicted mass (right)	1.4	7.2	11.1	-1.8	3.3
Whole body fat-free mass	1.4	8.3	12.2	-2.1	3.5
Whole body water mass	1.4	8.1	12.1	-2.0	3.5
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.1	1.1	-1.4
Peak expiratory flow (PEF)	1.3	3.0	6.1	0.1	2.5
Medication: Paracetamol	1.3	2.2	3.2	1.8	-1.1
Arm fat-free mass (right)	1.3	6.5	10.0	-1.7	3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.6	-0.7	1.6
Number of full sisters	1.3	1.6	3.0	1.7	0.4
Chest pain or discomfort	1.3	1.8	3.6	0.2	1.9
Hypertension (Self-reported)	1.3	3.5	4.6	2.1	-1.5
Medication: Lisinopril	1.3	1.7	2.0	-1.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.3	1.5	-0.9
Medication: Lansoprazole	1.2	1.4	2.7	1.6	0.4
Lung cancer (father)	1.2	1.3	1.8	-1.3	1.0
Number of full brothers	1.2	1.5	2.5	0.6	1.6
Had major operations	1.2	1.5	2.5	-0.6	1.6
Commuting to job workplace: Public transport	1.2	1.5	1.5	-1.2	1.2
Prostate Cancer	1.1	1.6	3.2	-0.0	-1.8
Blood Eosinophil Count	1.1	8.6	15.2	-3.9	1.4
Chronotype (morning person)	1.1	2.6	5.1	-2.3	-0.3
Sitting height	1.1	8.1	9.5	-3.1	2.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.4	1.8	-0.3
Falls in the last year	1.1	1.5	2.4	-0.7	1.6
Comparative body size at age 10	1.1	2.9	4.4	-1.2	2.1
Respiratory disease	1.0	2.3	2.5	-1.6	1.4
Hearing difficulty/problems: Yes	1.0	1.6	3.0	1.7	-0.4
Age when periods started (menarche)	1.0	2.4	3.6	1.0	1.9
Mouth/teeth dental problems	1.0	1.5	3.0	-1.7	-0.0
Allergy	1.0	2.2	4.1	0.6	-2.0
Neck or shoulder pain in last month	1.0	1.4	2.4	1.5	0.6
Wears glasses or contact lenses	1.0	1.1	1.2	-1.0	1.1
Bipolar Disorder (2018)	0.9	1.4	1.7	1.3	-1.0
Coronary Artery Disease (CAD)	0.9	1.0	1.8	0.5	-1.3
Impedance of leg (right)	0.9	4.2	5.8	1.6	-2.4
Alcohol usually taken with meals	0.9	1.5	2.4	-0.7	1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.8	1.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.5	-1.2	0.9
Trunk fat-free mass	0.9	5.1	7.1	-1.7	2.7
Worrier / anxious feelings	0.9	1.7	2.4	1.6	-1.0
Trunk predicted mass	0.9	5.3	7.5	-1.8	2.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.7	0.8	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	1.9	-1.1	1.4
Family relationship satisfaction	0.9	1.1	1.8	1.3	-0.7
Medication: Aspirin	0.9	1.2	2.2	0.5	-1.5
Smoking status: Current	0.9	1.4	2.1	1.5	-0.8
Average weekly beer plus cider intake	0.9	1.3	1.4	1.1	-1.2
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.0	-1.7	1.3
Cholesterol lowering medication	0.9	1.3	2.2	1.5	-0.6
Lung FEV1/FVC ratio	0.8	4.0	8.0	0.1	2.8
Hand grip strength (left)	0.8	2.2	3.8	2.0	-0.8
Relative age of first facial hair	0.8	1.6	3.2	1.8	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.9	1.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	0.3	-1.2
Hair/balding pattern: Pattern 2	0.8	1.1	1.4	-0.8	1.2
Had menopause	0.8	1.0	2.0	-0.1	1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.9	-0.5	1.4
Headache pain in last month	0.8	1.3	2.5	1.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.3	1.1	-0.8
Eye problems/disorders: Cataract	0.8	0.9	1.7	-1.3	-0.4
Risk taking	0.8	1.2	2.0	0.6	-1.4
Unable to work because of sickness or disability	0.8	1.0	1.2	1.0	-1.1
Ulcerative Colitis (UC)	0.7	1.2	2.2	1.5	-0.6
Breast Cancer	0.7	1.6	3.3	1.8	0.1
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.9	0.8	-1.4
Lung FVC	0.7	3.7	4.9	2.2	-1.6
Current tobacco smoking	0.7	1.1	2.0	1.4	-0.5
Medication: Simvastatin	0.7	1.1	2.0	1.4	-0.3
Father’s age at death	0.7	1.0	1.0	-1.0	1.0
Breast cancer (self-reported)	0.7	0.9	1.6	1.2	0.5
Medication: Aspirin	0.7	1.0	1.9	0.2	-1.4
Average weekly champagne plus white wine intake	0.7	1.0	1.6	1.3	-0.6
Stomach or abdominal pain in last month	0.6	0.8	1.4	0.4	1.2
Heart attack	0.6	0.7	1.4	-1.2	-0.2
Time employed in main current job	0.6	0.7	0.7	0.8	-0.9
Worry too long after embarrassment	0.6	1.0	1.0	0.9	1.0
Shortness of breath walking on level ground	0.6	0.7	1.3	0.1	1.1
Emphysema/chronic bronchitis	0.6	0.7	0.7	-0.8	-0.8
Overall health rating	0.6	1.3	2.5	1.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	0.9	0.7	-1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.6	0.9	1.0	-0.6
Alcohol drinker status: Previous	0.6	0.7	0.9	-0.9	-0.7
HDL Cholesterol	0.5	0.9	1.4	1.2	0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	1.1	-0.2
Chronic bronchitis/emphysema (father)	0.5	0.5	1.0	-1.0	0.3
High blood pressure (mother)	0.5	0.7	1.4	1.2	0.1
Pain all over the body in last month	0.5	0.5	0.9	0.4	-0.9
Medication: Ramipril	0.5	0.6	0.9	0.6	0.9
Noisy workplace	0.5	0.6	1.3	1.1	0.0
Illnesses of mother	0.5	0.6	1.0	-1.0	0.6
Glaucoma (self-reported)	0.5	0.6	1.0	1.0	-0.5
Age at first live birth	0.5	0.9	1.8	-1.3	-0.1
Suffer from ‘nerves’	0.5	0.8	1.7	1.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	0.6	0.9
Medication for cholesterol	0.5	0.7	1.3	-1.1	0.3
Mineral and other dietary supplements	0.5	0.7	1.0	-0.6	1.0
Impedance of whole body	0.5	2.6	3.2	1.4	-1.8
Mean Putamen Volume	0.4	0.5	0.9	0.2	-1.0
LDL Cholesterol	0.4	0.7	1.3	1.1	0.2
Sensitivity / hurt feelings	0.4	0.7	1.1	1.0	-0.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.6	0.8	-0.6
Medication for hormone replacement therapy	0.4	0.5	0.5	-0.7	0.7
Qualifications: CSEs or equivalent	0.4	0.5	0.9	0.5	0.9
Had other major operations	0.4	0.5	0.9	0.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	0.1	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	0.1	1.1
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.8	0.5
Breastfed as a baby	0.4	0.5	0.9	0.1	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.7	-0.8	0.8
Birth weight	0.4	0.8	1.6	-0.1	1.2
Medication: Ibuprofen	0.4	0.5	1.0	0.2	-1.0
Medication: Seretide 50 evohaler	0.4	0.5	0.9	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.0	-1.0	0.7
Ever had bowel cancer screening	0.4	0.5	0.9	1.0	-0.2
Friendships satisfaction	0.4	0.5	1.1	-0.0	1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Heart disease (siblings)	0.4	0.4	0.8	0.2	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	0.3	-0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.4	0.7
HbA1C	0.3	0.4	0.4	0.6	-0.6
Tanning	0.3	3.1	3.4	-1.7	1.9
Angina	0.3	0.4	0.6	-0.5	0.8
Average weekly fortified wine intake	0.3	0.4	0.5	-0.7	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	0.3	1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-0.6	1.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	-0.3	0.8
Exposure to tobacco smoke outside home	0.3	0.3	0.7	-0.2	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.3
Medication: Gliclazide	0.3	0.3	0.6	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	0.7	-0.8	0.7
Medication: Blood pressure	0.3	0.6	1.2	1.1	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.1	0.8
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	0.1	-0.7
Blood Red Count	0.2	2.4	4.4	-2.1	0.7
Blood White Count	0.2	1.7	2.9	1.7	-0.8
Allergy or Eczema	0.2	0.5	0.8	0.5	0.9
Average weekly spirits intake	0.2	0.3	0.5	-0.7	-0.3
Severe depression (siblings)	0.2	0.2	0.4	-0.2	0.6
Supplements: Glucosamine	0.2	0.3	0.3	0.6	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.3	-0.6	-0.5
Happiness	0.2	0.3	0.5	-0.1	0.7
Medication: Cholesterol lowering	0.2	0.4	0.4	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.3	-0.1	1.2
Standing height	0.2	1.9	2.5	-1.6	1.1
Loud music exposure frequency	0.2	0.2	0.2	-0.4	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.4	0.6	-0.5
Health satisfaction	0.2	0.2	0.3	0.4	0.5
Angina (self-reported)	0.2	0.2	0.3	-0.4	0.5
Migraine (self-reported)	0.2	0.3	0.6	-0.7	-0.0
Heart disease (mother)	0.2	0.3	0.3	0.5	0.6
Knee pain experienced in last month	0.2	0.3	0.4	0.5	-0.6
Loneliness, isolation	0.2	0.3	0.4	0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.7	-0.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.2	0.8
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.3	-0.7
Commuting to job workplace: Cycle	0.2	0.2	0.2	-0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.6	-0.2
Height	0.1	2.7	3.7	-1.3	1.9
Hair Pigment	0.1	1.5	2.5	1.6	-0.7
Systolic blood pressure, automated reading	0.1	0.2	0.2	-0.3	-0.5
Medication: Metformin	0.1	0.1	0.2	0.4	-0.3
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.6	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.6	0.2
Medication: Atenolol	0.1	0.2	0.3	0.2	-0.5
Impedance of arm (right)	0.1	0.4	0.6	0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.6	0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.2	0.4
Number of children fathered	0.1	0.1	0.1	-0.3	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.3	0.6	-0.0
Medication: Blood pressure	0.1	0.2	0.2	-0.4	-0.4
Alcohol intake frequency.	0.1	0.2	0.3	0.3	0.6
Comparative height size at age 10	0.1	0.4	0.7	-0.8	-0.3
Supplements: Vitamin C	0.1	0.1	0.2	0.4	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.2	0.4
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.2	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.5	-0.2
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.1
Age started oral contraceptive pill	0.1	0.2	0.3	-0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.4	0.1
Age at First Birth	0.0	0.0	0.0	0.0	-0.1
Fasting Glucose	0.0	0.0	0.1	-0.0	0.3
Triglycerides	0.0	0.1	0.1	-0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.0	-0.2
Pack years adult smoking proportion	0.0	0.1	0.1	-0.3	0.2
Hand grip strength (right)	0.0	0.1	0.1	-0.4	0.1
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.1	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.1	-0.3	-0.3
Diabetes (self-reported)	0.0	0.1	0.1	0.3	-0.2
Illnesses of siblings	0.0	0.1	0.1	0.3	-0.1
Impedance of arm (left)	0.0	0.1	0.1	0.4	-0.3
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.4	0.3
Birth weight of first child	0.0	0.0	0.0	-0.1	0.2
High blood pressure (siblings)	0.0	0.1	0.1	0.0	-0.3
Forced vital capacity (FVC), Best measure	0.0	0.1	0.1	0.3	-0.2
Medication: Omeprazole	0.0	0.1	0.1	-0.3	-0.1
Age at last live birth	0.0	0.1	0.1	0.3	-0.1
Financial situation satisfaction	0.0	0.0	0.1	0.0	-0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.1	0.1	0.3
Pack years of smoking	0.0	0.0	0.0	-0.1	0.0

Hub : Genes

PLCB3

Models

Trait associations