TWAS
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Traits
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Traits
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Whole body fat mass
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chr15:72,287,856-74,291,976
Best TWAS P=2.94e-09 · Best GWAS P=3.36e-13 conditioned to 0.000505
72.5M
73M
73.5M
74M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Nerve Tibial
NEO1
0.07
0.09
lasso
2
0.09
3.9e-07
-5.9
-5.9
2.9e-09
0.45
0.61
0.35
TRUE
3
GTEx
Pituitary
BBS4
0.27
0.02
enet
21
0.05
2.1e-02
-5.2
-5.5
4.7e-08
0.69
0.06
0.44
TRUE
4
GTEx
Testis
ADPGK-AS1
0.17
0.05
lasso
4
0.03
1.3e-02
-4.2
5.9
3.2e-09
-0.72
0.02
0.88
FALSE
1
GTEx
Esophagus Muscularis
NEO1
0.20
0.13
lasso
7
0.17
1.1e-10
-5.9
5.6
2.3e-08
-0.45
0.82
0.18
FALSE