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chr15:65,989,359-68,789,191

Best TWAS P=2.16e-18 · Best GWAS P=7.61e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	-7.7	8.7	2.2e-18	-0.64	0.77	0.09	TRUE
17	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	6.3	8.5	1.8e-17	-0.91	0.01	0.99	TRUE
25	METSIM	Adipose	MAP2K5	0.07	0.05	enet	19	0.06	2.8e-09	-8.5	7.6	2.3e-14	-0.60	0.36	0.64	TRUE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-5.5	7.6	4.2e-14	-0.62	0.09	0.08	TRUE
20	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	4.0	6.5	6.1e-11	-0.73	0.81	0.18	TRUE
12	GTEx	Cells Transformed fibroblasts	SMAD3	0.12	0.01	lasso	9	0.06	3.6e-05	-1.7	-6.5	7.2e-11	0.17	0.25	0.04	TRUE
24	METSIM	Adipose	IQCH	0.04	0.02	bslmm	593	0.02	3.3e-04	-2.6	6.0	1.8e-09	-0.64	0.31	0.48	TRUE
27	YFS	Blood	MAP2K1	0.07	0.05	lasso	3	0.05	2.0e-17	-5.1	5.5	3.4e-08	0.05	0.99	0.01	TRUE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	SMAD3	0.06	0.06	lasso	2	0.06	2.5e-07	5.8	5.4	6.8e-08	-0.03	0.83	0.11	TRUE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-5.5	8.5	1.3e-17	-0.57	0.37	0.22	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-7.9	8.5	2.6e-17	-0.63	0.01	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-7.9	8.2	1.8e-16	-0.65	0.29	0.53	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-6.7	8.2	2.3e-16	-0.65	0.92	0.08	FALSE
6	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-7.7	8.1	4.4e-16	-0.65	0.54	0.17	FALSE
22	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-7.7	8.0	1.1e-15	-0.68	0.99	0.01	FALSE
8	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-7.7	7.9	2.2e-15	-0.66	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCH	0.04	0.02	enet	8	0.01	1.6e-02	-6.6	7.9	2.6e-15	-0.71	0.12	0.11	FALSE
13	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-7.7	7.9	2.7e-15	-0.65	1.00	0.00	FALSE
19	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-7.7	7.9	3.0e-15	-0.65	0.20	0.52	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-7.7	7.9	3.1e-15	-0.66	0.48	0.38	FALSE
4	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-7.7	7.8	6.5e-15	-0.66	1.00	0.00	FALSE
14	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-7.7	7.8	8.6e-15	-0.80	0.06	0.93	FALSE
15	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-7.7	7.7	1.1e-14	-0.66	0.78	0.14	FALSE
18	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-7.7	7.7	1.1e-14	-0.66	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-7.8	7.6	2.4e-14	-0.64	0.89	0.06	FALSE
9	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-6.6	7.6	2.5e-14	-0.54	0.43	0.16	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-6.5	7.6	2.7e-14	-0.71	0.06	0.94	FALSE
28	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-7.7	7.5	4.4e-14	-0.63	1.00	0.00	FALSE
11	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	-8.6	7.5	8.6e-14	-0.62	0.37	0.62	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-5.5	7.4	1.2e-13	-0.66	0.11	0.78	FALSE
38	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IQCH	0.10	0.01	blup	111	0.03	1.4e-02	5.8	7.3	2.4e-13	-0.72	0.04	0.27	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	-5.5	7.3	3.1e-13	-0.69	0.64	0.25	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	-5.5	7.2	7.7e-13	-0.67	0.48	0.07	FALSE
7	GTEx	Artery Coronary	MAP2K5	0.11	0.00	enet	28	0.03	4.5e-02	-6.9	7.1	1.0e-12	-0.33	0.14	0.08	FALSE
16	GTEx	Lung	MAP2K5	0.12	0.09	enet	11	0.07	3.6e-06	-7.7	7.1	1.4e-12	-0.60	0.96	0.02	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	-7.8	7.1	1.5e-12	-0.53	0.36	0.44	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	-5.4	7.0	3.4e-12	-0.61	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	-6.7	-6.8	9.0e-12	0.38	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	-5.4	6.8	1.1e-11	-0.67	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-5.5	6.7	2.5e-11	-0.57	0.40	0.15	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAP2K5	0.11	0.07	bslmm	474	0.08	1.2e-09	-7.8	6.6	3.2e-11	-0.53	0.99	0.01	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-5.5	6.6	3.2e-11	-0.58	0.97	0.02	FALSE
26	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	-7.8	6.6	4.4e-11	-0.60	0.65	0.23	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCH	0.19	0.07	blup	111	0.16	7.4e-17	-2.9	6.6	4.7e-11	-0.70	1.00	0.00	FALSE
21	GTEx	Spleen	MAP2K5	0.25	0.19	lasso	3	0.18	2.1e-05	-7.7	6.3	3.2e-10	-0.45	0.41	0.24	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IQCH	0.13	0.11	bslmm	597	0.10	5.9e-12	-6.9	6.2	5.1e-10	-0.55	1.00	0.00	FALSE
10	GTEx	Brain Hippocampus	IQCH-AS1	0.20	0.08	enet	11	0.05	2.2e-02	4.0	-6.0	1.6e-09	0.74	0.12	0.35	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IQCH	0.13	0.01	blup	111	0.08	2.4e-05	-2.9	5.5	2.9e-08	-0.57	0.44	0.02	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	IQCH	0.08	0.09	enet	8	0.08	2.3e-05	-5.5	5.4	6.3e-08	-0.57	0.72	0.03	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	SNAPC5	0.05	0.02	lasso	2	0.03	5.1e-04	3.6	-5.2	2.5e-07	0.00	0.01	0.62	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	LBXCOR1	0.06	0.01	lasso	3	0.03	7.0e-04	-4.5	5.1	2.8e-07	-0.43	0.09	0.53	FALSE