Best TWAS P=6.43e-13 · Best GWAS P=7.06e-18 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ADAMTSL3 | 0.10 | 0.04 | lasso | 4 | 0.04 | 8.7e-06 | -6.74 | -5.5 | 3.6e-08 | 0.56 | 0.23 | 0.09 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LOC388152 | 0.14 | 0.14 | enet | 20 | 0.18 | 6.7e-22 | 5.16 | -6.9 | 5.6e-12 | 0.52 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | AC103965.1 | 0.24 | 0.14 | lasso | 6 | 0.15 | 2.6e-12 | 5.18 | -6.4 | 1.3e-10 | 0.40 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | CSPG4P11 | 0.19 | 0.17 | lasso | 5 | 0.20 | 7.9e-16 | 5.18 | -6.2 | 4.8e-10 | 0.38 | 1.00 | 0.00 | TRUE |
5 | GTEx | Adipose Visceral Omentum | GOLGA6L3 | 0.23 | 0.05 | lasso | 5 | 0.07 | 2.2e-04 | -6.03 | -5.3 | 9.7e-08 | 0.37 | 0.00 | 1.00 | TRUE |
6 | GTEx | Adrenal Gland | CSPG4P11 | 0.14 | -0.01 | enet | 15 | 0.04 | 1.7e-02 | 5.18 | -5.2 | 2.4e-07 | 0.22 | 0.15 | 0.05 | FALSE |
7 | GTEx | Artery Aorta | UBE2Q2P1 | 0.15 | 0.00 | enet | 21 | 0.05 | 8.4e-04 | -3.08 | 5.7 | 1.3e-08 | -0.46 | 0.26 | 0.15 | FALSE |
8 | GTEx | Artery Aorta | AC103965.1 | 0.10 | 0.12 | lasso | 3 | 0.10 | 3.9e-06 | 5.16 | -5.2 | 2.2e-07 | 0.30 | 0.92 | 0.05 | FALSE |
9 | GTEx | Artery Aorta | RP11-182J1.16 | 0.11 | 0.12 | lasso | 3 | 0.11 | 1.6e-06 | 5.18 | -5.1 | 2.8e-07 | 0.28 | 0.94 | 0.01 | FALSE |
10 | GTEx | Artery Aorta | CSPG4P11 | 0.11 | 0.10 | lasso | 4 | 0.08 | 3.1e-05 | 5.18 | -5.2 | 2.4e-07 | 0.30 | 0.92 | 0.01 | FALSE |
11 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -3.36 | -6.2 | 5.6e-10 | 0.38 | 0.44 | 0.36 | FALSE |
12 | GTEx | Artery Tibial | AC103965.1 | 0.27 | 0.26 | enet | 31 | 0.30 | 1.8e-23 | 5.12 | -5.9 | 2.9e-09 | 0.41 | 1.00 | 0.00 | FALSE |
13 | GTEx | Artery Tibial | CSPG4P11 | 0.16 | 0.24 | lasso | 4 | 0.23 | 3.0e-18 | 5.12 | -6.2 | 4.8e-10 | 0.41 | 1.00 | 0.00 | FALSE |
14 | GTEx | Brain Caudate basal ganglia | AC103965.1 | 0.28 | 0.25 | lasso | 7 | 0.25 | 6.7e-08 | 4.92 | -5.6 | 2.3e-08 | 0.37 | 0.82 | 0.04 | FALSE |
15 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 5.18 | -6.8 | 8.6e-12 | 0.53 | 0.08 | 0.43 | FALSE |
16 | GTEx | Brain Cortex | GOLGA6L4 | 0.42 | 0.21 | lasso | 7 | 0.28 | 2.8e-08 | -6.36 | -6.7 | 1.9e-11 | 0.65 | 0.17 | 0.75 | FALSE |
17 | GTEx | Brain Cortex | AC103965.1 | 0.17 | 0.19 | lasso | 3 | 0.16 | 4.3e-05 | 4.92 | -5.9 | 4.8e-09 | 0.40 | 0.21 | 0.44 | FALSE |
18 | GTEx | Brain Nucleus accumbens basal ganglia | GOLGA6L4 | 0.21 | 0.04 | lasso | 5 | 0.09 | 2.3e-03 | -6.95 | -5.6 | 2.0e-08 | 0.55 | 0.06 | 0.18 | FALSE |
19 | GTEx | Brain Nucleus accumbens basal ganglia | AC103965.1 | 0.29 | 0.23 | enet | 21 | 0.27 | 6.9e-08 | 4.87 | -6.2 | 7.4e-10 | 0.45 | 0.84 | 0.10 | FALSE |
20 | GTEx | Breast Mammary Tissue | AC103965.1 | 0.13 | 0.11 | lasso | 1 | 0.13 | 2.9e-07 | 5.12 | -5.1 | 3.1e-07 | 0.31 | 0.92 | 0.02 | FALSE |
21 | GTEx | Breast Mammary Tissue (Male) | GOLGA6L4 | 0.23 | 0.07 | lasso | 2 | 0.12 | 8.3e-04 | -6.36 | -6.3 | 2.2e-10 | 0.57 | 0.07 | 0.33 | TRUE |
22 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 4.92 | -6.9 | 5.3e-12 | 0.55 | 0.07 | 0.58 | FALSE |
23 | GTEx | Cells Transformed fibroblasts | AC103965.1 | 0.15 | 0.09 | lasso | 7 | 0.11 | 1.3e-08 | 5.18 | -7.0 | 2.8e-12 | 0.56 | 0.68 | 0.31 | FALSE |
24 | GTEx | Colon Sigmoid | RP11-182J1.14 | 0.31 | 0.29 | lasso | 9 | 0.30 | 2.7e-11 | 4.97 | 5.3 | 1.2e-07 | -0.36 | 1.00 | 0.00 | FALSE |
25 | GTEx | Colon Transverse | GOLGA6L3 | 0.18 | 0.17 | lasso | 4 | 0.14 | 2.2e-07 | -6.03 | -5.2 | 1.8e-07 | 0.36 | 0.00 | 1.00 | FALSE |
26 | GTEx | Colon Transverse | AC103965.1 | 0.15 | 0.07 | enet | 33 | 0.06 | 7.1e-04 | -6.06 | -6.9 | 6.2e-12 | 0.50 | 0.10 | 0.53 | FALSE |
27 | GTEx | Colon Transverse | CSPG4P11 | 0.10 | 0.10 | lasso | 4 | 0.08 | 1.2e-04 | -6.06 | -6.2 | 6.3e-10 | 0.40 | 0.25 | 0.04 | FALSE |
28 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 5.12 | -6.2 | 7.4e-10 | 0.47 | 1.00 | 0.00 | FALSE |
29 | GTEx | Esophagus Mucosa | RP11-182J1.16 | 0.20 | 0.05 | lasso | 5 | 0.10 | 1.8e-07 | 4.97 | -6.5 | 8.3e-11 | 0.46 | 0.89 | 0.02 | FALSE |
30 | GTEx | Esophagus Mucosa | CSPG4P11 | 0.21 | 0.01 | enet | 28 | 0.08 | 3.7e-06 | -6.06 | -6.5 | 1.0e-10 | 0.56 | 0.61 | 0.32 | FALSE |
31 | GTEx | Esophagus Muscularis | UBE2Q2P1 | 0.34 | 0.03 | lasso | 7 | 0.15 | 1.9e-09 | 2.58 | 6.3 | 2.2e-10 | -0.42 | 0.34 | 0.28 | TRUE |
32 | GTEx | Esophagus Muscularis | AC103965.1 | 0.18 | 0.14 | enet | 16 | 0.14 | 7.6e-09 | 4.92 | -5.9 | 3.3e-09 | 0.40 | 1.00 | 0.00 | FALSE |
33 | GTEx | Lung | AC103965.1 | 0.20 | 0.14 | lasso | 4 | 0.16 | 1.8e-12 | 5.12 | -6.4 | 1.3e-10 | 0.42 | 1.00 | 0.00 | FALSE |
34 | GTEx | Muscle Skeletal | NMB | 0.07 | 0.00 | enet | 23 | 0.00 | 9.9e-02 | -3.68 | -5.5 | 3.2e-08 | 0.39 | 0.11 | 0.46 | FALSE |
35 | GTEx | Nerve Tibial | UBE2Q2P1 | 0.13 | 0.01 | enet | 37 | 0.04 | 1.3e-03 | 5.16 | 5.6 | 2.8e-08 | -0.20 | 0.10 | 0.40 | FALSE |
36 | GTEx | Nerve Tibial | AC103965.1 | 0.20 | 0.22 | enet | 17 | 0.27 | 5.1e-19 | 5.12 | -6.6 | 3.0e-11 | 0.49 | 1.00 | 0.00 | FALSE |
37 | GTEx | Ovary | AC103965.1 | 0.27 | 0.22 | lasso | 3 | 0.24 | 1.6e-06 | 5.18 | -6.4 | 1.9e-10 | 0.43 | 0.34 | 0.12 | FALSE |
38 | GTEx | Pancreas | AC103965.1 | 0.29 | 0.23 | lasso | 9 | 0.18 | 2.8e-08 | 5.18 | -5.6 | 1.7e-08 | 0.39 | 1.00 | 0.00 | FALSE |
39 | GTEx | Pancreas | RP11-182J1.16 | 0.08 | -0.01 | enet | 11 | -0.01 | 7.9e-01 | -6.06 | -6.9 | 6.6e-12 | 0.62 | 0.03 | 0.52 | FALSE |
40 | GTEx | Pituitary | AC103965.1 | 0.30 | 0.16 | enet | 10 | 0.24 | 8.4e-07 | 5.11 | -6.0 | 1.9e-09 | 0.52 | 0.28 | 0.46 | FALSE |
41 | GTEx | Prostate | RP11-182J1.16 | 0.24 | 0.06 | enet | 27 | 0.08 | 6.2e-03 | 0.60 | -6.7 | 2.1e-11 | 0.48 | 0.07 | 0.31 | FALSE |
42 | GTEx | Prostate | CSPG4P11 | 0.34 | 0.07 | enet | 13 | 0.18 | 2.3e-05 | -2.89 | -6.7 | 2.8e-11 | 0.42 | 0.06 | 0.70 | FALSE |
43 | GTEx | Skin Not Sun Exposed Suprapubic | AC103965.1 | 0.23 | 0.15 | lasso | 8 | 0.19 | 1.9e-10 | 5.18 | -5.8 | 6.0e-09 | 0.37 | 0.96 | 0.02 | FALSE |
44 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-182J1.16 | 0.10 | 0.01 | enet | 13 | 0.04 | 3.1e-03 | 0.89 | -5.2 | 1.5e-07 | 0.40 | 0.37 | 0.06 | FALSE |
45 | GTEx | Skin Sun Exposed Lower leg | ZSCAN2 | 0.08 | 0.02 | enet | 13 | 0.03 | 1.4e-03 | -6.04 | 5.7 | 1.2e-08 | -0.34 | 0.38 | 0.07 | FALSE |
46 | GTEx | Skin Sun Exposed Lower leg | AC103965.1 | 0.33 | 0.17 | enet | 24 | 0.23 | 4.8e-19 | 5.12 | -7.2 | 6.4e-13 | 0.50 | 1.00 | 0.00 | TRUE |
47 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -7.74 | 6.3 | 2.4e-10 | -0.37 | 0.06 | 0.17 | TRUE |
48 | GTEx | Spleen | GOLGA6L4 | 0.55 | 0.20 | enet | 19 | 0.40 | 2.6e-11 | -6.06 | -7.1 | 1.6e-12 | 0.54 | 0.87 | 0.04 | FALSE |
49 | GTEx | Testis | RP11-182J1.14 | 0.10 | 0.19 | lasso | 1 | 0.17 | 6.7e-08 | 5.12 | 5.1 | 3.1e-07 | -0.31 | 0.94 | 0.00 | FALSE |
50 | GTEx | Thyroid | AC103965.1 | 0.30 | 0.25 | lasso | 7 | 0.25 | 1.8e-19 | 5.18 | -6.1 | 1.2e-09 | 0.37 | 1.00 | 0.00 | FALSE |
51 | GTEx | Thyroid | RP11-182J1.16 | 0.10 | 0.02 | lasso | 7 | 0.05 | 1.3e-04 | -6.70 | -5.5 | 4.8e-08 | 0.56 | 0.38 | 0.32 | FALSE |
52 | GTEx | Whole Blood | GOLGA6L4 | 0.12 | 0.08 | enet | 16 | 0.11 | 2.1e-10 | -5.05 | -6.8 | 1.2e-11 | 0.58 | 0.80 | 0.20 | TRUE |
53 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBE2Q2P1 | 0.07 | 0.04 | blup | 22 | 0.06 | 1.8e-07 | 5.18 | 5.4 | 8.4e-08 | -0.37 | 0.66 | 0.28 | FALSE |
54 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | UBE2Q2P1 | 0.10 | 0.00 | blup | 22 | 0.03 | 1.9e-02 | -5.45 | 6.1 | 1.3e-09 | -0.40 | 0.00 | 0.42 | TRUE |
55 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBE2Q2P1 | 0.03 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 5.18 | 5.7 | 1.2e-08 | -0.36 | 0.04 | 0.21 | FALSE |
56 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GOLGA6L5 | 0.09 | 0.08 | enet | 4 | 0.09 | 5.2e-06 | -2.28 | -5.5 | 4.9e-08 | 0.44 | 0.01 | 0.84 | FALSE |