Hub : Genes

CSPG4P11

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1850 0.0580 6.0e-12 0.169 NA 0.167 NA 0.195 9.7e-14 NA 1.4e-13 NA 7.9e-16
2 GTEx Adipose Visceral Omentum 0.1450 0.0510 7.8e-06 0.073 NA 0.087 NA 0.085 1.3e-04 NA 2.9e-05 NA 3.7e-05
3 GTEx Adrenal Gland 0.1385 0.0645 1.3e-03 -0.006 NA 0.038 NA 0.009 6.3e-01 NA 1.7e-02 NA 1.5e-01
4 GTEx Artery Aorta 0.1090 0.0460 1.7e-04 0.098 NA 0.070 NA 0.081 4.7e-06 NA 1.0e-04 NA 3.1e-05
5 GTEx Artery Coronary 0.1750 0.0930 5.2e-03 0.020 NA 0.106 NA 0.063 6.7e-02 NA 2.0e-04 NA 3.6e-03
6 GTEx Artery Tibial 0.1555 0.0395 2.4e-15 0.242 NA 0.221 NA 0.234 6.1e-19 NA 2.9e-17 NA 3.0e-18
7 GTEx Brain Cerebellar Hemisphere 0.3030 0.1130 2.1e-04 0.212 NA 0.111 NA 0.158 3.9e-06 NA 8.7e-04 NA 7.6e-05
8 GTEx Brain Cerebellum 0.2800 0.0800 2.1e-06 0.233 NA 0.252 NA 0.275 1.6e-07 NA 4.5e-08 NA 9.0e-09
9 GTEx Breast Mammary Tissue 0.0850 0.0370 1.1e-03 0.076 NA 0.034 NA 0.051 1.0e-04 NA 7.1e-03 NA 1.3e-03
10 GTEx Breast Mammary Tissue (Male) 0.0453 0.0485 2.0e-01 0.024 NA -0.013 NA 0.029 9.4e-02 NA 8.7e-01 NA 7.1e-02
11 GTEx Breast Mammary Tissue (Female) 0.1715 0.0641 5.8e-04 0.153 NA 0.105 NA 0.103 2.6e-05 NA 5.1e-04 NA 5.4e-04
12 GTEx Cells Transformed fibroblasts 0.1900 0.0580 1.5e-11 0.181 NA 0.170 NA 0.166 1.4e-13 NA 9.8e-13 NA 1.9e-12
13 GTEx Colon Sigmoid 0.1900 0.0920 1.4e-03 0.013 NA 0.041 NA 0.021 1.1e-01 NA 1.4e-02 NA 6.0e-02
14 GTEx Colon Transverse 0.0960 0.0480 6.0e-03 0.101 NA 0.069 NA 0.080 1.6e-05 NA 3.4e-04 NA 1.2e-04
15 GTEx Esophagus Gastroesophageal Junction 0.1750 0.0960 2.6e-03 0.057 NA 0.055 NA 0.059 4.1e-03 NA 4.6e-03 NA 3.5e-03
16 GTEx Esophagus Mucosa 0.2110 0.0650 1.2e-07 0.012 NA 0.082 NA 0.077 4.6e-02 NA 3.7e-06 NA 7.9e-06
17 GTEx Esophagus Muscularis 0.1210 0.0410 3.1e-07 0.164 NA 0.157 NA 0.180 3.5e-10 NA 8.4e-10 NA 4.0e-11
18 GTEx Heart Atrial Appendage 0.1210 0.0460 2.5e-05 0.082 NA 0.073 NA 0.096 1.6e-04 NA 3.6e-04 NA 4.2e-05
19 GTEx Heart Left Ventricle 0.1078 0.0524 1.5e-03 0.025 NA -0.005 NA 0.003 1.7e-02 NA 7.6e-01 NA 2.2e-01
20 GTEx Muscle Skeletal 0.1383 0.0427 1.7e-08 0.073 NA 0.061 NA 0.083 1.2e-07 NA 1.3e-06 NA 1.4e-08
21 GTEx Nerve Tibial 0.2318 0.0536 5.6e-17 0.234 NA 0.251 NA 0.270 1.3e-16 NA 8.0e-18 NA 3.0e-19
22 GTEx Ovary 0.2120 0.0920 4.7e-04 0.171 NA 0.146 NA 0.182 5.6e-05 NA 2.0e-04 NA 3.1e-05
23 GTEx Prostate 0.3370 0.1130 4.1e-05 0.072 NA 0.184 NA 0.070 7.3e-03 NA 2.2e-05 NA 7.8e-03
24 GTEx Skin Not Sun Exposed Suprapubic 0.2870 0.0760 3.2e-09 0.074 NA 0.133 NA 0.127 6.7e-05 NA 9.6e-08 NA 1.9e-07
25 GTEx Skin Sun Exposed Lower leg 0.1760 0.0460 3.7e-12 0.070 NA 0.187 NA 0.192 1.8e-06 NA 2.4e-15 NA 9.1e-16
26 GTEx Thyroid 0.1700 0.0450 2.0e-11 0.078 NA 0.141 NA 0.118 1.5e-06 NA 6.1e-11 NA 2.5e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
Bipolar Disorder (2018) 9.5 15.0 24.1 4.4 4.5 1.9 4.6 3.5 4.0 -4.3 -4.6 4.3 1.5 3.4 4.4 2.7 2.3 3.6 2.5 4.7 4.4 4.9 4.1 3.9 4.4 2.0 4.2 4.1 4.3
Bipolar Disorder or Schizophrenia 16.9 41.1 59.6 7.5 6.8 4.3 7.6 6.1 7.2 -7.3 -7.5 6.6 3.3 4.8 7.2 5.4 4.3 6.5 5.5 7.6 7.0 7.7 6.6 6.8 7.1 3.9 6.5 6.0 6.6
Depressed Affect (Nagel 2018) 0.5 1.0 2.3 -0.9 -0.6 -1.0 -1.3 -1.5 -1.2 1.1 0.9 -0.4 -1.4 0.4 -0.9 -1.5 0.2 -0.7 -0.5 -1.4 -0.6 -1.1 -0.2 -1.3 -0.9 -1.0 0.5 0.9 0.9
Depression (Nagel 2018) 0.3 0.5 1.8 -0.8 -0.7 -0.4 -0.7 -0.4 -0.9 0.8 0.7 -0.2 -1.1 -0.0 -0.6 -1.1 -0.7 -0.6 -0.8 -0.7 -0.4 -0.6 -0.3 -0.7 -0.3 -1.3 0.1 -0.5 -0.2
Intelligence (Savage-Jansen 2018) 0.9 2.9 6.9 -1.8 -1.6 -1.7 -1.6 -0.5 -2.0 2.1 1.7 -1.5 -1.7 -1.2 -1.3 -1.7 -1.4 -2.5 -2.6 -1.5 -1.8 -1.5 -1.7 -1.9 -1.1 -1.8 -1.4 -1.6 -1.7
Neuroticism (Nagel 2018) 0.3 0.8 2.1 -0.9 -0.8 -0.9 -1.2 -1.4 -1.0 0.9 0.8 -0.7 -0.6 -0.2 -1.0 -1.2 -0.1 -0.5 -0.3 -1.4 -0.8 -1.2 -0.5 -1.4 -1.2 -1.0 -0.1 0.4 0.4
Schizophrenia (2018) 12.7 26.4 36.6 6.0 5.1 3.9 6.0 5.0 6.0 -6.0 -5.9 5.0 3.1 3.4 5.8 4.8 3.7 5.4 5.0 6.0 5.5 6.0 5.2 5.6 5.5 3.4 5.0 4.3 5.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.5 -0.1 -0.3 -0.0 -0.1 -0.3 0.3 0.0 0.2 -0.3 0.1 -0.5 -0.3 0.4 0.0 0.1 -0.0 -0.1 -0.3 -0.3 -0.4 -0.0 -0.2 0.5 -0.5 -0.7 -0.6
Worry (Nagel 2018) 0.1 0.1 0.4 -0.0 -0.4 -0.6 -0.2 -0.5 0.1 -0.2 0.1 -0.4 -0.2 -0.4 -0.1 -0.6 0.3 0.2 0.4 -0.4 -0.3 -0.3 -0.2 -0.4 -0.6 -0.3 0.1 0.3 0.5
Alzheimer’s Disease (in mother) 0.2 0.2 0.8 0.7 0.1 0.5 0.5 -0.2 0.6 -0.4 -0.3 -0.1 0.7 -0.5 0.0 0.4 0.9 0.5 -0.2 0.5 0.1 0.2 0.1 0.2 0.1 0.6 -0.2 -0.1 -0.5
Alzheimer’s Disease (in father) 1.4 1.5 3.2 1.4 1.4 1.8 1.4 0.5 1.3 -1.5 -1.5 1.3 0.8 1.0 1.4 1.4 0.6 1.6 0.2 1.4 1.4 1.3 1.3 1.6 1.6 0.9 0.7 0.6 0.9
Alzheimer’s Disease (including proxy) 1.8 2.6 7.6 2.0 1.4 1.9 1.9 1.1 2.0 -2.1 -1.8 1.2 2.8 0.4 1.4 1.5 1.3 2.4 0.9 1.9 1.6 1.5 1.5 1.6 1.6 0.8 0.9 1.0 1.2
Crohns Disease (2017) 1.2 2.7 8.8 1.4 1.5 1.3 0.8 1.0 0.9 -1.4 -0.7 1.7 0.6 2.2 1.2 0.6 3.0 1.1 1.7 0.9 1.4 1.3 1.9 1.3 1.4 2.9 2.2 2.8 2.0
Irritable Bowel Disease (IBD) 0.9 2.1 10.3 1.1 1.0 1.0 0.3 0.3 0.6 -0.6 -0.3 1.3 -0.1 2.0 0.7 -0.5 3.2 0.3 1.0 0.5 1.0 0.8 1.7 0.6 0.8 2.9 2.5 3.1 1.9
Ulcerative Colitis (UC) 0.3 0.6 3.2 0.2 0.2 -0.0 -0.4 -0.8 -0.2 0.4 0.4 0.3 -0.5 0.9 -0.3 -1.2 1.7 -0.5 -0.4 -0.3 0.1 -0.0 0.5 -0.5 -0.3 1.4 1.2 1.8 0.8
Major Depression (MDD) 1.5 1.8 3.9 1.0 1.1 1.4 0.7 1.8 0.8 -0.7 -0.7 1.7 0.1 1.9 1.3 0.9 1.6 0.9 1.4 1.0 1.4 1.2 1.8 1.1 1.7 1.3 1.8 1.3 2.0
Reaction Time 0.1 0.2 1.3 0.5 0.1 -0.5 0.3 0.6 0.5 0.1 -0.3 0.1 -0.6 -0.2 0.6 0.0 1.0 -0.7 0.2 0.3 0.2 0.5 0.3 0.1 0.2 1.1 0.4 0.1 1.0
Verbal and Numeric Reasoning (VNR) 1.7 4.2 9.6 -2.2 -1.6 -2.7 -1.9 -1.4 -2.1 2.6 1.7 -1.6 -1.8 -1.0 -2.0 -2.3 -2.0 -3.0 -3.1 -2.0 -1.9 -1.8 -2.1 -2.4 -1.4 -2.4 -1.5 -1.5 -1.5
Breast Cancer 0.9 2.2 4.9 -2.1 -0.7 -1.7 -1.7 -1.1 -1.8 1.3 1.3 -1.0 -0.4 -0.4 -2.1 -0.2 -1.7 -0.6 -1.6 -1.5 -1.4 -1.5 -1.6 -1.2 -1.3 -1.4 -2.2 -2.2 -1.6
Ovarian Cancer 0.1 0.2 1.2 -0.2 0.0 -0.2 0.0 0.2 0.1 -0.5 -0.2 -0.2 -0.2 -0.4 0.0 0.7 -0.4 0.2 -1.1 0.0 -0.1 -0.2 -0.4 0.2 -0.1 0.2 -0.8 -0.5 -0.8
Prostate Cancer 0.2 0.3 0.7 -0.4 -0.8 -0.3 -0.7 0.2 -0.4 0.2 0.7 -0.8 0.3 -0.8 -0.7 -0.3 0.4 -0.3 -0.1 -0.7 -0.8 -0.6 -0.6 -0.6 -0.7 0.2 -0.0 0.1 -0.2
Age at First Birth 0.2 0.4 1.6 -0.4 -0.2 -0.3 -0.8 -0.7 -0.5 0.8 0.7 -0.4 0.4 0.2 -0.9 0.4 1.2 -0.3 0.3 -0.6 -0.5 -0.6 -0.2 -0.6 -0.5 1.3 0.4 0.4 0.2
Bipolar Disorder (2011) 7.8 7.5 12.0 3.1 2.5 2.7 3.4 3.5 3.2 -3.2 -3.0 2.5 2.1 1.2 3.3 3.1 1.2 3.0 2.7 3.5 2.9 3.2 2.6 3.2 3.1 1.1 2.1 1.5 1.9
Body Mass Index (BMI) (2010) 0.3 0.4 3.3 0.5 0.6 -0.3 0.6 0.8 0.5 -1.1 -0.6 0.2 1.8 0.0 0.4 0.2 0.1 1.2 0.1 0.6 0.3 0.5 0.2 0.5 0.4 0.0 0.2 0.6 0.8
Coronary Artery Disease (CAD) 0.7 0.8 3.7 0.7 0.6 0.3 0.3 -0.9 0.2 -0.4 -0.4 0.9 -1.3 1.0 0.2 -0.5 1.3 0.2 1.7 0.4 0.8 0.4 0.9 0.3 0.8 0.8 1.9 1.2 1.5
Crohns Disease (2012) 0.4 0.6 2.0 0.8 0.6 0.2 0.6 0.7 0.7 -0.8 -0.7 0.6 -0.2 0.6 0.9 0.8 1.4 0.5 0.5 0.6 0.6 0.6 0.8 0.7 0.5 1.1 0.9 1.2 0.9
Mean Putamen Volume 3.9 4.4 8.2 2.2 2.7 1.6 2.6 0.6 2.6 -2.4 -2.5 2.8 0.4 2.4 2.0 0.9 0.1 2.3 0.2 2.6 2.8 2.5 2.3 2.4 2.9 1.0 1.9 1.7 1.8
Fasting Glucose 0.3 0.4 1.6 -0.7 -1.0 -0.4 -0.4 -0.0 -0.3 0.4 0.9 -0.0 -0.5 -0.6 0.1 -0.2 -1.3 -0.4 -0.4 -0.6 -0.5 -0.2 -0.6 -0.2 -0.3 -0.3 -1.0 -1.3 -0.7
HbA1C 0.6 0.7 1.8 -1.0 -1.4 -0.8 -1.0 -0.8 -1.0 0.0 1.2 -0.9 -1.0 -0.7 -0.7 -1.3 -1.0 -0.2 -0.6 -1.2 -0.7 -0.9 -0.5 -1.1 -0.7 -0.5 -0.1 -0.2 -0.5
HDL Cholesterol 1.4 2.3 6.1 1.7 1.3 1.4 1.3 0.9 1.5 -0.7 -1.1 1.4 1.1 1.4 1.5 0.6 1.9 0.7 1.9 1.3 1.4 1.4 1.6 1.4 1.4 2.5 2.3 2.1 1.9
LDL Cholesterol 0.2 0.3 1.1 -0.0 0.8 -0.9 -0.1 0.3 -0.2 -0.3 -0.4 0.6 -0.0 1.0 -0.3 0.1 0.7 -0.6 -0.5 0.1 0.3 0.3 0.4 -0.2 0.7 -0.2 0.6 0.6 0.6
Lupus 0.7 1.0 4.9 0.4 1.1 1.1 -0.0 1.5 0.2 0.1 -0.2 1.5 1.1 2.2 0.3 -0.5 1.5 0.8 -0.4 0.0 1.0 0.5 1.5 -0.0 1.6 1.2 1.2 0.9 1.0
Neuroticism (2016) 0.4 0.5 2.1 -0.6 -0.1 -0.1 -0.1 -0.1 -0.3 -0.1 0.1 -0.6 1.3 -0.8 -0.7 -0.1 -1.4 0.2 -1.3 -0.1 -0.5 -0.2 -1.0 -0.2 -0.4 -1.0 -1.1 -1.4 -1.0
Primary Biliary Cirrhosis 0.2 0.3 2.2 0.5 -0.6 -0.2 0.3 0.4 0.6 -0.3 -0.3 -0.6 0.5 -1.2 0.4 0.4 0.5 0.3 1.5 0.2 -0.2 0.1 -0.2 0.0 -0.5 -0.2 1.0 0.7 0.4
Rheumatoid Arthritis 0.6 0.9 6.4 -0.9 -0.7 -1.1 -1.0 -0.8 -1.1 1.0 0.3 -0.7 0.3 -0.4 -1.1 -0.2 -1.1 -0.5 -0.1 -1.1 -0.8 -1.0 -0.8 -1.4 -0.9 -2.5 0.1 0.5 -0.1
Schizophrenia (2014) 10.1 22.2 32.5 5.5 5.0 3.5 5.6 4.4 5.6 -5.5 -5.7 4.7 2.9 3.0 5.3 4.9 3.1 5.0 4.4 5.6 5.1 5.4 4.7 5.1 5.1 2.8 4.3 3.8 4.4
Triglycerides 0.7 1.1 4.0 -1.0 -0.3 -1.4 -0.5 -0.5 -0.9 0.6 0.1 -0.5 -2.0 -0.5 -0.6 -0.4 -1.8 -1.1 -1.7 -0.5 -0.6 -0.6 -0.8 -0.8 -0.4 -2.0 -1.1 -1.5 -1.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 -0.8 -0.3 -1.0 -0.7 -1.5 -0.9 0.7 0.4 -0.4 -1.2 -0.0 -1.0 -1.3 -0.9 -0.9 -0.9 -0.8 -0.5 -0.6 -0.6 -1.0 -0.4 -1.4 -0.2 -0.2 -0.4
Ulcerative Colitis 0.3 0.5 4.0 0.4 -0.3 0.3 -0.1 -0.7 -0.2 0.4 0.3 -0.4 -1.2 -0.4 -0.0 -0.8 2.0 -0.8 -0.2 -0.1 -0.3 -0.1 0.2 -0.4 -0.4 1.2 0.8 1.1 0.3
Blood Eosinophil Count 2.9 22.3 39.4 4.8 5.3 5.0 4.2 1.8 4.0 -4.5 -4.2 6.0 2.6 6.3 3.8 3.5 4.5 4.1 3.5 4.6 5.4 5.0 5.7 4.3 5.6 3.6 5.9 6.2 5.1
Blood Platelet Count 2.0 22.9 37.4 5.5 4.8 5.4 4.6 1.5 4.5 -4.2 -3.8 5.4 1.1 5.3 4.7 1.8 5.8 3.7 3.4 4.7 5.3 4.9 5.9 4.9 5.4 6.1 5.9 5.8 5.2
Blood Red Count 1.2 11.4 18.7 -3.8 -3.9 -2.2 -4.0 -3.1 -4.3 3.9 4.1 -3.4 -3.3 -2.4 -3.3 -3.1 -1.8 -3.5 -2.0 -3.9 -3.8 -4.0 -3.3 -3.7 -3.9 -2.8 -2.4 -2.5 -3.7
Blood White Count 0.5 3.5 12.9 1.3 2.5 2.5 1.3 0.8 0.7 -1.5 -1.5 2.8 1.0 3.6 1.4 0.2 1.0 2.2 0.2 1.7 2.2 1.7 2.2 1.9 2.5 1.4 2.4 2.1 1.3
Heel T-Score 2.0 16.0 27.5 4.4 4.5 3.6 4.7 3.6 4.3 -4.6 -5.2 4.0 4.9 2.5 4.0 4.5 1.6 4.2 3.4 4.7 4.3 4.5 3.9 3.8 4.7 -0.2 3.3 3.4 3.6
BMI 0.2 1.4 9.8 -1.4 -0.2 -1.6 -0.7 -0.6 -0.1 -0.1 0.2 -0.4 2.1 -0.2 -1.1 -0.7 -3.1 1.1 -1.6 -0.9 -0.6 -0.7 -1.4 -0.6 -0.7 -1.9 -1.6 -1.1 -0.6
Height 12.5 240.6 436.8 -18.1 -12.2 -11.8 -16.9 -16.5 -20.9 18.2 15.6 -11.6 -18.4 -5.8 -16.7 -14.0 -13.3 -17.2 -17.1 -16.3 -14.2 -16.3 -13.3 -15.7 -12.9 -16.3 -14.6 -14.7 -17.5
Waist Hip Ratio (WHR) 2.7 12.2 26.3 -4.6 -4.5 -1.1 -5.0 -0.7 -5.1 4.7 5.1 -3.5 -1.8 -1.9 -3.6 -2.2 -1.4 -3.8 -1.7 -4.5 -4.0 -4.4 -3.0 -3.3 -3.6 -1.6 -2.4 -3.2 -3.5
Systolic Blood Pressure 0.3 1.5 8.9 -1.2 -0.9 -1.1 -0.5 0.7 -0.8 0.7 0.2 -1.1 0.6 -1.4 -0.6 0.1 -3.0 -0.7 -0.5 -0.6 -0.8 -0.6 -1.3 -0.6 -0.9 -3.0 -1.7 -2.1 -0.6
Smoking Status 0.4 0.8 4.2 -0.8 -0.5 -0.5 -0.8 -2.1 -1.0 0.7 0.7 -0.5 0.1 -0.2 -1.8 -1.5 -0.2 -0.5 -1.0 -0.7 -0.7 -0.9 -0.8 -1.2 -0.3 -0.8 -0.4 -0.3 -1.3
Allergy or Eczema 1.8 4.8 8.8 2.8 2.4 2.3 2.8 1.1 2.9 -2.3 -2.5 2.3 1.1 1.5 2.5 3.0 1.7 1.8 1.2 2.8 2.5 2.5 2.2 2.3 2.5 1.8 1.4 1.8 0.8
Cardiovascular Disease 1.6 5.4 15.9 -2.7 -2.2 -2.2 -1.9 -1.5 -2.1 1.7 1.7 -2.3 0.4 -2.3 -2.5 -1.7 -4.0 -1.3 -2.5 -2.1 -2.3 -2.1 -2.9 -2.0 -2.2 -3.5 -2.7 -3.0 -2.2
Hypothyroidism (self reported) 3.5 8.1 14.7 -3.2 -3.0 -2.6 -3.0 -2.0 -3.2 3.0 2.8 -3.0 -1.5 -2.4 -3.2 -1.6 -2.6 -2.8 -1.5 -2.9 -3.2 -3.3 -3.2 -3.3 -2.8 -3.6 -2.4 -2.4 -3.8
Respiratory disease 1.2 2.7 8.0 1.7 1.6 0.3 1.5 1.7 2.2 -1.6 -1.4 1.2 2.2 0.9 1.5 2.1 2.2 1.6 1.3 1.4 1.4 1.6 1.4 1.5 1.1 2.8 1.5 1.6 2.0
Type 2 Diabetes (T2D) (2018) 2.4 4.6 8.8 -2.5 -1.9 -1.8 -2.8 -2.6 -3.0 2.4 2.5 -1.8 -2.0 -0.9 -2.9 -2.3 -0.6 -1.9 -1.3 -2.7 -2.3 -2.6 -1.8 -2.5 -2.1 -1.4 -1.4 -1.4 -1.6
Lung FEV1/FVC ratio 5.5 27.9 69.2 -6.8 -3.6 -1.8 -5.3 -4.3 -7.2 5.2 4.5 -3.4 -2.2 -1.6 -5.4 -4.8 -8.2 -4.0 -6.6 -5.0 -4.5 -5.3 -4.9 -4.7 -3.8 -8.3 -5.8 -6.2 -6.7
Lung FVC 0.5 2.6 10.7 1.0 1.6 2.0 0.6 -1.2 0.3 -0.3 -0.4 2.2 -0.5 3.3 1.2 0.1 1.7 0.4 0.9 0.5 1.7 1.2 2.3 1.6 1.8 2.4 1.8 2.2 2.6
Neuroticism 0.4 1.1 2.1 -1.1 -0.9 -1.1 -1.3 -1.4 -1.1 1.0 1.1 -0.9 -0.8 -0.4 -1.3 -1.4 -0.3 -0.8 -1.1 -1.4 -1.0 -1.2 -0.9 -1.3 -1.3 -0.8 -0.8 -0.6 -0.2
Chronotype (morning person) 1.4 3.3 10.7 -1.4 -1.9 -1.8 -1.3 -3.3 -1.5 1.4 1.0 -1.8 -1.9 -2.0 -1.8 -2.0 -1.8 -1.6 -0.2 -1.6 -1.6 -1.8 -1.9 -2.1 -2.1 -3.2 -1.1 -0.8 -1.3
Hair Pigment 0.0 0.9 2.1 -1.0 -0.9 -1.3 -1.2 -0.9 -1.3 1.0 1.0 -1.0 -1.4 -0.3 -1.2 -0.6 0.4 -1.5 -0.6 -1.4 -1.1 -0.9 -0.7 -1.3 -0.6 -0.4 -0.2 -0.0 -0.1
Tanning 0.0 0.3 1.8 0.3 -0.3 -0.3 0.0 -0.5 0.2 -0.2 -0.2 -0.3 0.1 -0.3 0.1 -0.9 0.9 -0.0 1.3 -0.0 -0.1 -0.1 -0.1 -0.3 -0.5 -0.3 1.2 1.3 0.8
Hand grip strength (left) 1.3 3.4 12.1 1.3 2.1 2.5 0.8 0.8 0.9 -0.7 -0.7 2.7 0.6 3.5 1.3 1.4 2.3 0.8 0.2 1.1 2.1 1.6 2.7 1.7 2.3 3.4 1.5 1.6 1.7
Number of treatments/medications taken 0.2 0.4 2.9 -0.9 -0.6 0.1 -0.7 1.3 -0.7 0.3 0.6 -0.5 1.7 -0.4 -0.5 0.0 -1.0 0.9 -0.0 -0.6 -0.7 -0.5 -0.7 -0.2 -0.5 -0.1 -0.1 -0.3 -0.0
Average weekly spirits intake 0.1 0.1 1.2 0.0 0.2 -0.7 0.2 -0.4 0.1 -0.0 -0.4 0.1 -0.0 0.1 -0.3 0.2 -0.4 -0.2 -0.0 0.1 0.1 0.3 -0.1 -0.3 0.3 -1.1 0.0 -0.1 0.1
Sensitivity / hurt feelings 0.9 1.6 3.7 1.3 1.5 0.7 1.2 0.4 0.9 -0.9 -1.6 1.5 -0.0 1.5 1.2 1.3 0.9 0.8 1.6 1.1 1.4 1.4 1.4 0.7 1.5 -0.1 1.8 1.9 1.9
Frequency of depressed mood in last 2 weeks 2.0 2.8 8.2 -1.8 -1.9 -1.4 -1.5 -1.4 -1.6 1.1 1.5 -1.5 -1.7 -1.6 -1.9 -2.1 -2.4 -1.3 -1.1 -1.4 -1.5 -1.8 -1.8 -1.4 -1.7 -2.9 -0.9 -1.8 -1.3
Hearing difficulty/problems: Yes 3.4 5.1 15.4 1.6 3.2 1.9 1.7 1.8 1.8 -1.9 -2.1 3.2 2.4 3.9 1.5 1.6 0.8 2.9 0.7 2.0 2.7 2.4 2.6 2.0 2.8 1.3 2.2 2.3 2.5
Relative age of first facial hair 2.8 5.8 11.3 -2.9 -2.1 -3.4 -2.6 -2.0 -2.6 2.4 2.5 -2.1 -2.2 -1.4 -2.9 -1.7 -2.4 -2.5 -1.6 -2.6 -2.5 -2.6 -2.6 -2.4 -2.5 -2.3 -2.3 -2.6 -2.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 1.2 -0.1 0.4 0.3 -0.1 0.0 -0.3 0.2 0.1 0.3 0.1 0.9 0.3 -0.4 0.1 0.1 -0.7 -0.2 0.1 0.2 0.3 0.2 -0.1 1.1 0.2 0.5 0.4
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.8 1.5 1.4 1.0 1.3 1.1 1.3 -1.5 -1.5 1.3 1.7 0.9 0.9 1.9 1.6 1.7 1.4 1.4 1.4 1.3 1.4 1.1 1.8 0.6 1.5 1.3 1.1
Ever had hysterectomy (womb removed) 0.2 0.2 1.2 -0.7 -0.4 -1.1 -0.5 0.3 -0.6 0.3 0.3 -0.3 -0.3 0.1 -0.3 0.2 -0.7 -0.4 -0.6 -0.4 -0.4 -0.4 -0.3 -0.6 -0.2 -1.0 0.3 0.1 -0.4
Systolic blood pressure, automated reading 0.2 0.5 2.2 0.4 0.3 -0.2 0.9 1.5 0.7 -0.6 -0.9 0.3 0.2 -0.4 0.7 0.6 -1.2 0.2 0.6 0.9 0.4 0.7 0.0 0.5 0.8 -1.3 -0.2 -0.8 0.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.3 -0.5 -0.5 0.5 -0.6 -1.0 -0.5 0.3 0.9 -0.3 -1.1 0.0 -0.6 -0.7 0.0 -0.3 -0.8 -0.6 -0.4 -0.6 -0.1 0.0 -0.5 0.7 -0.1 -0.2 -0.4
Angina 0.3 0.4 1.6 -0.4 -1.3 0.7 -0.8 0.7 -0.9 0.8 1.1 -0.6 0.3 -0.3 -0.3 -0.1 1.0 -0.4 0.5 -0.7 -0.7 -0.6 -0.2 -0.3 -0.4 0.9 0.5 -0.1 0.0
Medication for hormone replacement therapy 0.6 0.6 2.3 0.5 1.1 1.2 0.5 0.4 0.4 -0.3 -0.4 1.2 0.9 1.5 0.4 -0.2 0.2 0.4 -1.2 0.6 0.9 0.9 1.0 0.7 1.3 0.6 0.5 0.7 0.6
Vitamin and mineral supplements 1.1 1.4 5.0 -1.6 -0.8 -0.7 -1.3 -1.4 -1.0 0.9 0.8 -0.9 0.2 -0.4 -1.4 -0.6 -1.8 -0.7 -2.2 -1.4 -1.0 -1.2 -1.3 -1.0 -1.1 -1.1 -1.8 -1.2 -1.3
Supplements: Zinc 0.4 0.4 2.8 -0.6 0.2 -1.4 -0.1 0.3 -0.4 0.5 -0.2 -0.3 -0.1 -0.6 -0.6 -0.6 -1.7 -0.5 0.1 -0.1 -0.3 -0.1 -0.6 -0.5 -0.3 -1.3 -0.4 -1.0 -0.4
Medication: Co-codamol 2.3 2.7 4.2 -1.8 -1.6 -1.7 -1.6 -1.4 -1.3 1.6 1.4 -1.8 0.1 -1.7 -2.0 -1.8 -1.8 -1.4 -1.4 -1.7 -1.8 -1.8 -2.1 -1.8 -2.0 -1.6 -1.6 -1.5 -1.1
Medication: Metformin 0.7 1.0 4.5 -1.0 -0.6 -0.5 -1.1 -1.8 -1.5 1.1 1.1 -0.6 -2.1 -0.0 -0.9 -1.0 -0.4 -1.1 -0.7 -1.1 -0.8 -0.9 -0.5 -0.8 -0.7 -0.5 -0.6 -0.6 -0.8
Diabetes (father) 2.0 2.5 9.6 -1.9 -1.0 -1.8 -1.8 -3.1 -2.1 1.5 1.4 -1.0 -1.7 -0.1 -2.3 -1.0 -1.5 -1.0 -1.0 -1.9 -1.4 -1.6 -1.4 -1.6 -1.4 -1.8 -1.1 -1.1 -0.6
Diabetes (mother) 1.0 1.3 2.7 1.0 1.0 1.6 1.1 0.7 1.1 -1.5 -1.1 1.1 0.6 1.0 1.5 1.3 -0.1 1.3 1.2 0.9 1.3 1.1 1.2 1.6 1.0 0.2 0.9 1.1 1.5
Severe depression (siblings) 0.3 0.3 1.3 0.1 1.1 -0.3 0.5 0.1 0.5 -0.5 -0.7 1.1 -0.1 1.1 -0.1 0.2 -0.6 0.5 0.2 0.6 0.7 0.6 0.5 0.2 0.9 -0.5 0.4 0.1 0.1
Pack years adult smoking proportion 1.5 2.3 4.1 -1.9 -1.7 -1.6 -1.8 0.0 -1.9 1.5 1.5 -1.6 -0.2 -1.3 -1.6 -0.5 -1.3 -1.2 -0.5 -1.7 -1.7 -1.8 -1.7 -1.7 -1.4 -2.0 -1.4 -1.8 -1.4
Impedance of leg (right) 13.9 67.4 151.3 -9.6 -5.6 -6.7 -9.3 -7.6 -12.3 10.1 8.0 -5.5 -11.3 -1.4 -8.1 -7.4 -5.2 -9.8 -10.9 -8.6 -7.5 -8.6 -6.5 -8.8 -6.8 -8.2 -7.0 -6.1 -8.9
Leg fat-free mass (left) 0.9 4.8 14.0 -2.7 -1.9 -2.1 -2.1 -1.9 -1.8 1.5 1.8 -1.9 -0.2 -1.7 -2.6 -1.2 -3.7 -0.9 -2.2 -2.2 -2.0 -2.1 -2.5 -1.7 -1.8 -3.0 -2.9 -3.1 -2.3
Trunk fat percentage 9.0 36.0 66.6 -7.7 -3.7 -6.2 -6.7 -4.8 -8.2 6.9 5.3 -3.7 -5.2 -0.8 -6.5 -5.7 -6.6 -5.4 -8.1 -6.3 -5.3 -6.1 -5.4 -6.6 -4.6 -7.5 -5.8 -5.2 -6.5
Hand grip strength (right) 0.5 1.4 8.5 0.1 0.7 1.7 -0.5 0.1 -0.5 0.7 0.7 1.4 -0.6 2.5 0.3 -0.0 2.1 -0.6 0.4 -0.2 0.8 0.2 1.6 0.4 0.9 2.9 1.2 1.2 1.1
Townsend deprivation index at recruitment 0.2 0.3 1.2 0.2 -0.2 -0.3 0.5 1.0 0.8 -0.4 -0.4 -0.2 0.1 -0.9 0.7 0.8 -1.1 -0.2 -0.3 0.3 0.0 0.4 -0.2 0.2 -0.1 -0.6 -1.0 -0.7 -0.2
Current tobacco smoking 0.3 0.5 1.9 0.3 0.9 0.8 0.4 0.5 0.3 -0.8 -0.2 0.9 1.4 1.1 0.3 0.4 0.2 1.3 -0.2 0.6 0.7 0.7 0.7 0.8 1.0 0.7 0.0 0.1 -0.0
Average weekly fortified wine intake 0.9 1.0 3.7 -0.6 -0.6 -1.3 -0.5 -1.9 -0.6 0.7 0.3 -1.2 -1.4 -1.5 -1.3 -0.9 -0.7 -0.7 0.0 -0.6 -0.9 -1.2 -1.2 -1.0 -1.1 -1.0 -0.9 -1.1 -1.0
Maternal smoking around birth 0.6 0.8 4.2 0.6 0.3 1.5 0.3 1.9 0.4 -0.4 0.0 0.6 2.1 0.8 0.9 1.3 1.1 0.6 1.1 0.4 0.5 0.4 0.8 0.8 0.4 0.8 0.6 0.8 0.1
Fed-up feelings 2.3 4.2 6.2 -2.3 -2.3 -2.0 -2.2 -1.4 -2.0 1.8 2.2 -2.1 -1.3 -1.7 -1.9 -2.1 -2.4 -1.5 -2.0 -2.3 -2.1 -2.3 -2.2 -2.1 -2.3 -2.5 -1.9 -1.7 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 4.1 -1.4 -1.4 -1.3 -1.2 -0.3 -1.3 1.4 1.2 -1.3 -1.6 -1.1 -0.9 -1.1 -1.4 -1.3 -1.0 -1.1 -1.3 -1.2 -1.2 -1.3 -1.1 -2.0 -0.7 -1.2 -0.9
Relative age voice broke 0.8 1.2 3.7 -1.6 -0.5 -1.5 -1.2 0.4 -1.3 0.8 1.0 -0.6 -0.1 0.0 -1.1 -0.4 -1.8 -0.6 -1.9 -1.0 -1.0 -1.0 -1.1 -0.7 -0.9 -0.9 -1.2 -1.4 -1.2
Taking other prescription medications 0.3 0.4 2.1 0.1 0.4 1.0 0.1 1.5 0.0 -0.0 -0.0 0.7 1.1 0.9 0.6 0.6 0.1 0.8 0.3 0.2 0.4 0.4 0.7 0.6 0.6 0.8 0.8 0.7 0.7
Age when periods started (menarche) 2.9 7.0 12.7 2.6 3.1 2.2 2.3 1.8 2.1 -2.2 -2.4 3.2 1.2 3.3 2.6 2.2 2.5 2.3 2.9 2.6 2.9 2.7 3.2 2.4 2.7 2.1 3.4 3.6 2.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.1 0.3 0.4 0.0 0.4 1.0 0.3 -0.7 -0.6 0.4 0.7 0.3 0.5 0.2 -0.4 0.6 0.1 0.5 0.5 0.5 0.4 0.2 0.7 -1.0 0.6 0.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 5.5 1.5 1.0 1.6 1.8 1.1 1.7 -1.9 -1.9 0.7 2.3 -0.3 1.2 1.6 -0.8 1.7 0.8 1.7 1.2 1.4 0.7 1.2 1.3 -1.1 0.4 0.2 0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 -0.5 -0.8 -0.1 -0.8 -0.4 -0.6 0.4 0.8 -0.5 -0.3 -0.3 -0.8 -0.7 0.7 -0.4 0.3 -0.7 -0.7 -0.9 -0.4 -0.5 -0.6 0.6 0.1 -0.3 -0.6
Qualifications: CSEs or equivalent 0.8 1.0 2.8 1.2 0.9 1.7 1.2 0.6 1.3 -1.6 -1.1 0.8 0.8 0.3 1.1 1.3 0.3 1.4 0.5 1.0 1.1 0.9 1.0 1.4 0.6 0.7 0.2 0.1 0.5
Serious illness, injury or assault to yourself 0.5 0.7 3.3 -1.0 -0.8 -0.2 -0.7 0.1 -0.8 0.7 1.0 -0.4 -1.0 -0.1 -0.4 -1.3 -1.1 -0.8 -1.8 -0.6 -0.6 -0.6 -0.6 -0.5 -0.4 0.2 -0.9 -0.8 -1.1
High blood pressure 0.9 2.6 10.4 -1.9 -1.4 -1.5 -1.1 -0.5 -1.3 0.8 1.0 -1.5 0.3 -1.7 -1.5 -1.4 -3.2 -0.7 -2.0 -1.3 -1.5 -1.3 -2.1 -1.3 -1.1 -2.6 -1.9 -2.2 -1.6
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.1 1.6 1.1 1.6 1.4 -0.5 1.6 -1.1 -1.1 1.0 0.5 0.4 1.0 1.3 1.6 1.1 0.6 1.2 1.2 1.0 1.0 1.1 0.8 1.8 0.6 1.0 0.2
Multivitamins +/- minerals 1.7 2.1 6.1 1.6 1.1 1.2 1.3 2.1 1.2 -1.3 -1.0 1.2 0.8 0.8 1.4 1.8 1.7 1.4 2.5 1.5 1.3 1.4 1.6 1.4 1.4 1.2 1.8 1.3 1.5
Stomach or abdominal pain in last month 0.1 0.1 0.6 0.1 -0.0 0.1 0.1 0.8 0.3 -0.3 -0.1 -0.1 -0.6 -0.3 0.4 0.3 -0.0 -0.0 -0.5 0.1 0.1 0.2 0.0 0.3 0.1 0.4 -0.3 -0.6 0.2
Supplements: Glucosamine 2.2 2.8 4.6 -1.8 -1.7 -1.8 -1.9 -2.1 -1.7 2.1 2.0 -1.6 -1.9 -0.9 -2.0 -1.6 -0.7 -1.8 -1.0 -2.0 -1.7 -2.0 -1.6 -1.9 -1.9 -0.5 -1.4 -1.3 -1.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.5 1.1 -0.8 -0.7 -1.0 -0.7 -0.4 -0.6 0.5 0.6 -0.7 -0.9 -0.6 -0.5 -0.7 -0.7 -0.9 -1.0 -0.9 -0.7 -0.9 -0.8 -0.7 -0.4 -0.8 -0.6 -0.6 -0.8
Medication: Atenolol 0.9 1.2 3.1 0.6 0.3 -0.1 1.3 1.6 1.4 -1.5 -1.3 0.1 1.8 -1.0 0.8 1.6 -1.7 1.5 -0.7 1.2 0.5 0.9 -0.2 1.2 0.7 -0.7 -0.8 -1.2 -0.1
Medication: Levothyroxine sodium 1.1 1.9 4.2 -1.4 -1.5 -0.7 -1.4 -0.9 -1.5 1.5 1.3 -1.7 -0.6 -1.5 -1.4 -0.5 -1.1 -1.4 -0.0 -1.4 -1.7 -1.7 -1.6 -1.6 -1.5 -1.6 -1.2 -1.1 -2.0
Sitting height 6.0 42.7 68.2 -7.7 -5.8 -6.5 -7.1 -6.7 -8.3 7.0 6.1 -5.7 -7.2 -3.6 -7.0 -5.3 -6.0 -7.1 -6.3 -7.1 -6.5 -6.9 -6.3 -6.7 -6.0 -7.8 -5.4 -6.0 -5.9
Chronic bronchitis/emphysema (father) 2.9 3.4 5.6 2.2 1.5 0.5 2.0 2.2 2.4 -2.0 -2.0 1.6 0.7 0.8 2.0 2.3 1.6 1.3 2.2 2.1 1.8 2.0 1.8 1.6 2.0 1.2 2.2 1.8 1.9
High blood pressure (mother) 1.0 1.3 3.3 1.1 1.4 0.5 1.2 1.1 1.0 -1.5 -1.8 1.1 1.4 0.9 1.3 0.9 0.0 1.3 0.6 1.0 1.2 1.3 1.1 1.0 1.0 -0.7 1.0 1.2 1.7
Body mass index (BMI) 0.6 2.7 13.9 0.8 1.8 0.1 1.4 2.2 1.9 -2.1 -1.9 1.6 3.7 1.3 1.2 1.5 -1.5 3.0 0.6 1.3 1.5 1.5 0.9 1.5 1.7 -0.5 0.4 0.6 1.5
Impedance of leg (left) 12.5 60.9 136.9 -9.1 -5.3 -6.3 -8.9 -7.4 -11.7 9.7 7.7 -5.1 -11.0 -1.1 -7.7 -7.5 -5.0 -9.4 -10.2 -8.3 -7.1 -8.1 -6.1 -8.3 -6.5 -7.5 -6.4 -5.6 -8.2
Leg predicted mass (left) 0.9 4.7 14.2 -2.7 -1.8 -2.1 -2.0 -1.8 -1.8 1.4 1.8 -1.9 -0.2 -1.6 -2.5 -1.2 -3.8 -0.9 -2.3 -2.1 -2.0 -2.1 -2.4 -1.7 -1.7 -3.0 -2.9 -3.1 -2.3
Trunk fat mass 8.4 36.0 64.2 -7.8 -3.8 -6.2 -6.7 -4.9 -8.0 6.6 5.3 -3.9 -5.0 -1.1 -6.5 -5.5 -7.0 -5.2 -8.0 -6.3 -5.4 -6.1 -5.5 -6.4 -4.6 -7.7 -6.0 -5.5 -6.5
Waist circumference 2.2 8.1 22.1 -4.1 -1.5 -2.8 -3.2 -1.2 -3.8 3.0 2.2 -1.6 -0.6 -0.1 -3.1 -1.5 -4.7 -1.6 -4.0 -3.0 -2.4 -2.8 -2.7 -2.6 -2.0 -4.4 -3.3 -3.1 -2.9
Number of incorrect matches in round 2.8 4.7 7.9 2.3 2.3 1.9 2.0 1.7 2.1 -2.8 -2.0 2.2 2.4 1.9 1.7 1.7 2.3 2.5 1.9 2.0 2.1 2.3 2.2 2.1 2.2 2.2 2.2 2.3 2.5
Past tobacco smoking 0.1 0.2 0.8 -0.1 -0.1 0.1 0.2 0.8 -0.0 -0.0 0.1 -0.3 -0.4 -0.5 0.5 0.4 -0.6 -0.1 -0.5 0.1 -0.1 0.2 -0.1 0.4 -0.3 0.1 -0.9 -0.8 -0.2
Alcohol usually taken with meals 0.2 0.4 2.2 0.7 0.4 -0.3 0.9 -1.2 0.5 -0.3 -0.7 0.3 -1.5 -0.3 0.3 -0.6 -0.3 -0.2 -0.4 0.9 0.5 0.4 0.2 0.4 0.4 -0.9 0.3 0.0 -0.1
Nervous feelings 0.6 1.1 2.7 1.2 0.5 0.7 1.1 1.2 1.3 -1.4 -0.8 0.7 0.9 0.2 1.2 0.8 1.0 1.6 1.6 1.0 0.9 1.1 0.9 1.0 0.8 0.6 1.1 0.9 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.4 0.6 0.1 0.9 0.4 0.6 0.6 -0.4 0.0 0.6 0.1 0.4 0.5 0.0 0.7 0.4 0.9 0.4 0.6 0.6 0.8 0.7 0.6 0.7 1.2 0.6 1.2
Hearing difficulty/problems with background noise 1.7 2.7 5.1 1.4 1.9 1.0 1.4 2.0 1.5 -1.3 -1.5 2.2 0.8 2.3 1.6 1.2 1.0 1.6 1.5 1.7 1.9 1.9 1.9 1.4 1.8 1.0 2.2 1.8 1.7
Hair/balding pattern: Pattern 2 0.4 0.5 3.0 0.2 -0.4 -0.0 -0.4 -0.4 -0.4 0.4 0.3 -0.4 -1.3 -0.2 -0.0 -0.4 1.7 -0.8 0.7 -0.4 -0.4 -0.3 0.1 -0.5 -0.3 0.8 1.0 1.2 1.0
Had menopause 4.3 5.4 13.0 2.3 3.3 2.0 2.5 1.2 1.9 -2.0 -2.5 3.4 -0.3 3.4 2.2 1.6 0.9 1.3 0.7 2.9 3.1 2.7 2.9 2.4 3.6 0.8 2.2 2.0 1.2
Had other major operations 0.2 0.3 1.9 0.2 -0.3 0.1 -0.0 0.6 -0.2 0.4 0.2 0.2 -0.5 0.4 1.0 0.5 0.7 -0.4 1.4 -0.1 0.1 0.1 0.4 0.2 0.2 0.2 0.9 0.8 0.7
Forced vital capacity (FVC) 3.5 13.6 31.6 -4.4 -2.8 -2.5 -4.6 -4.1 -5.6 4.8 4.2 -2.2 -5.2 0.0 -3.6 -3.4 -2.1 -4.8 -4.2 -4.5 -3.2 -4.0 -2.4 -3.5 -3.1 -2.8 -3.0 -2.8 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.6 1.2 0.9 1.4 1.3 0.7 1.1 -1.2 -1.4 0.7 1.9 0.0 0.8 1.1 -0.1 1.2 0.7 1.3 0.9 0.9 0.7 0.7 1.0 -1.2 0.4 0.5 0.5
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.3 1.2 1.0 1.2 1.3 0.2 1.5 -1.3 -1.2 1.0 0.7 0.7 1.0 0.4 0.3 1.2 0.1 1.3 1.2 1.3 1.0 1.1 1.2 1.1 0.8 1.0 1.0
Qualifications: None of the above 0.5 1.0 4.9 0.5 1.0 1.0 0.3 1.7 0.2 -0.7 -0.7 1.0 1.3 1.3 0.9 2.2 0.6 1.2 1.1 0.4 0.8 0.7 1.1 0.6 1.1 0.0 0.6 1.2 1.0
Financial difficulties in last 2 years 0.2 0.3 2.9 0.2 -0.2 0.6 0.2 1.7 0.4 -0.3 -0.0 -0.1 1.4 -0.5 0.7 0.9 0.1 0.3 0.9 0.2 0.1 0.2 0.2 0.3 0.3 0.0 0.5 0.1 0.5
Mouth/teeth dental problems 1.3 2.1 5.1 -1.5 -1.0 -1.0 -1.7 -1.9 -1.7 1.7 1.7 -1.0 -1.7 -0.2 -1.7 -0.8 0.2 -2.2 -2.3 -1.5 -1.4 -1.7 -1.2 -1.3 -1.2 0.1 -1.2 -1.1 -1.4
Heart attack 0.7 0.8 2.3 -1.1 -1.5 -0.2 -1.3 0.4 -1.1 0.9 1.5 -1.3 0.2 -0.9 -0.9 -0.9 -0.1 -0.7 -0.1 -1.1 -1.3 -1.1 -1.0 -0.9 -1.2 -0.1 0.0 -0.4 -0.4
Allergy 1.8 4.2 9.2 -2.4 -2.0 -2.1 -2.1 -1.5 -2.7 2.1 1.8 -1.8 -2.3 -1.2 -1.9 -2.0 -2.2 -2.4 -1.9 -2.1 -2.0 -2.0 -1.9 -1.9 -1.7 -3.0 -1.6 -1.9 -1.8
Pain all over the body in last month 0.5 0.6 2.7 0.2 0.4 1.1 -0.3 0.8 -0.4 0.2 0.1 0.4 1.2 1.2 0.3 0.8 1.6 0.3 0.3 -0.3 0.2 0.2 0.9 0.2 0.1 1.1 0.8 1.5 1.1
Diabetes (self-reported) 0.3 0.4 1.3 -0.7 -0.6 -0.3 -0.8 -1.2 -0.9 0.5 0.9 -0.4 -0.8 -0.1 -0.8 -1.0 -0.1 -0.1 -0.2 -0.8 -0.7 -0.7 -0.4 -0.6 -0.6 -0.5 -0.1 -0.2 -0.2
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.3 -1.0 -0.6 -1.3 -0.7 -1.4 -0.8 0.9 0.5 -1.2 -0.1 -1.3 -1.1 -0.8 -1.4 -0.5 -1.0 -1.0 -1.0 -1.2 -1.5 -0.9 -1.5 -1.1 -1.1 -1.0 -1.2
Medication: Ramipril 0.2 0.3 1.2 -0.6 -0.0 -0.8 -0.2 -0.3 -0.7 0.8 0.4 0.1 -0.7 0.5 -0.5 -1.0 -1.1 -0.5 -0.9 -0.1 -0.1 0.1 -0.3 -0.5 -0.0 -0.8 -0.4 -0.4 -0.3
Medication: Simvastatin 0.4 0.6 2.9 0.3 0.4 1.3 0.7 0.8 0.6 -0.9 -0.8 0.6 1.7 0.1 0.3 0.9 -1.3 1.4 0.2 0.8 0.7 0.6 0.3 1.0 0.6 -0.8 0.6 0.0 0.2
Fluid intelligence score 2.3 4.7 10.6 -2.4 -2.1 -2.8 -2.2 -1.6 -2.4 2.4 1.8 -2.0 -1.8 -1.5 -2.3 -1.5 -2.1 -2.9 -2.3 -2.2 -2.2 -2.2 -2.3 -2.6 -1.8 -3.3 -1.6 -1.5 -1.8
Illnesses of siblings 0.2 0.3 2.9 -0.3 -0.8 0.3 -0.4 -0.5 -0.0 0.5 0.6 -0.4 -0.2 -0.7 -0.6 -1.7 -0.5 -0.2 0.5 -0.2 -0.3 -0.6 -0.4 -0.4 -0.5 -0.4 0.4 -0.3 -0.1
Neuroticism score 0.2 0.4 1.3 -0.8 -0.7 -0.5 -1.0 -0.4 -0.7 0.6 0.9 -0.5 -0.1 0.0 -0.8 -1.2 -0.4 -0.3 -0.5 -1.0 -0.6 -0.7 -0.5 -0.9 -0.8 -0.6 -0.1 -0.1 0.3
Weight 3.5 17.0 35.3 -5.4 -2.7 -4.2 -4.4 -3.5 -5.1 4.0 3.5 -2.7 -2.8 -1.0 -4.5 -3.3 -5.9 -2.9 -5.4 -4.3 -3.6 -4.1 -4.0 -3.9 -3.1 -5.8 -4.5 -4.5 -4.3
Impedance of arm (right) 11.0 51.1 106.1 -7.9 -5.2 -6.1 -7.8 -7.1 -10.1 9.2 7.1 -5.0 -10.3 -1.8 -7.2 -7.1 -3.6 -9.1 -8.7 -7.3 -6.7 -7.3 -5.8 -8.1 -6.0 -6.1 -6.0 -5.3 -7.9
Arm fat percentage (right) 1.0 4.0 13.5 -2.7 -0.5 -2.9 -2.0 -0.6 -2.5 1.8 1.0 -0.7 -0.6 0.3 -1.9 -1.5 -3.5 -0.9 -3.2 -1.8 -1.5 -1.6 -1.8 -2.2 -0.9 -3.7 -2.3 -1.8 -2.0
Trunk fat-free mass 1.0 5.5 15.2 -3.0 -1.9 -2.0 -2.3 -2.4 -2.4 1.7 2.0 -2.0 -0.9 -1.5 -2.8 -1.4 -3.9 -1.3 -2.6 -2.3 -2.1 -2.4 -2.5 -1.7 -1.8 -3.3 -2.9 -3.3 -2.3
Hip circumference 3.4 14.7 37.2 -4.9 -1.4 -4.5 -3.7 -3.5 -4.7 3.6 2.3 -2.0 -2.5 -0.2 -4.1 -2.7 -6.0 -2.6 -6.1 -3.6 -2.9 -3.5 -3.6 -3.6 -2.5 -6.1 -4.4 -3.9 -4.0
Time employed in main current job 1.1 1.3 3.9 1.4 0.8 1.5 1.2 1.2 1.2 -0.7 -1.2 0.7 1.0 0.4 1.6 2.0 1.4 0.9 1.3 1.0 0.9 1.2 1.1 1.0 0.8 1.2 0.8 1.3 0.9
Alcohol intake versus 10 years previously 0.2 0.3 0.9 -0.7 -0.8 -0.1 -0.9 0.5 -0.7 0.4 0.9 -0.6 0.8 -0.2 -0.2 -0.1 0.1 0.0 -0.1 -0.9 -0.7 -0.8 -0.5 -0.5 -0.9 -0.0 -0.4 0.2 -0.0
Father’s age at death 0.4 0.6 1.4 1.0 0.5 0.6 0.8 0.1 0.8 -0.3 -0.5 0.7 -0.7 0.6 0.9 0.3 1.2 0.2 0.8 0.8 0.7 0.9 0.9 0.8 0.5 1.2 1.2 0.6 0.8
Worrier / anxious feelings 0.1 0.3 1.5 -0.3 0.0 0.1 -0.3 0.2 -0.1 0.1 0.2 0.3 1.2 0.7 -0.4 -0.9 -0.6 0.6 0.0 -0.3 0.0 0.0 0.1 -0.4 -0.2 -0.5 0.4 0.8 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 3.5 -1.0 -0.8 -1.1 -0.7 0.4 -0.8 0.2 0.4 -1.1 0.9 -1.3 -0.6 0.0 -1.7 0.5 -1.0 -0.8 -0.9 -0.7 -1.2 -0.6 -1.2 -1.9 -1.2 -1.2 -0.6
Falls in the last year 1.7 2.3 4.3 -1.4 -1.9 -1.1 -1.8 -1.7 -2.0 1.6 1.9 -1.7 -2.1 -1.2 -1.2 -1.9 -0.1 -1.3 -1.3 -2.0 -1.7 -1.8 -1.2 -1.4 -1.9 -0.2 -1.1 -0.9 -0.7
Hair/balding pattern: Pattern 3 2.2 3.2 6.9 2.3 1.3 1.5 2.1 1.7 2.3 -2.0 -1.9 1.0 0.8 0.0 2.2 2.6 1.7 1.9 2.6 2.1 1.6 1.8 1.6 2.1 1.4 1.8 1.5 1.0 1.5
Number of live births 2.9 4.1 7.7 2.2 1.9 1.8 1.8 1.7 1.8 -1.3 -1.6 2.2 1.0 2.0 2.0 1.7 2.6 1.6 2.8 2.0 2.0 2.0 2.3 1.6 2.3 2.1 2.8 2.5 2.3
Forced expiratory volume in 1-second (FEV1) 6.5 22.0 46.8 -5.7 -3.4 -2.9 -5.5 -5.2 -6.8 5.7 4.9 -2.9 -5.6 -0.5 -4.6 -4.1 -4.1 -5.5 -6.0 -5.4 -4.0 -4.9 -3.5 -4.3 -3.8 -4.7 -4.7 -4.3 -4.3
Pulse rate 0.1 0.1 0.8 -0.1 -0.1 -0.5 0.2 0.9 0.1 -0.1 -0.3 -0.3 -0.1 -0.7 0.3 0.4 -0.3 0.4 0.4 0.3 -0.2 0.1 -0.3 -0.1 0.2 -0.6 0.4 -0.2 0.0
Happiness 0.6 0.7 2.4 -1.0 -0.7 -0.0 -0.9 -0.6 -0.8 0.5 1.0 -0.7 -0.7 -0.5 -1.0 -1.4 -1.0 -0.5 -1.5 -0.8 -0.7 -0.9 -0.6 -0.6 -0.6 -0.7 -0.8 -0.8 -0.9
Noisy workplace 0.9 1.2 2.3 1.0 1.3 1.4 0.9 1.5 0.8 -0.9 -0.8 1.3 0.7 1.3 1.1 1.4 1.1 1.3 0.3 1.2 1.1 1.1 1.1 1.0 1.2 0.9 0.7 1.0 0.6
Qualifications: A levels/AS levels or equivalent 2.7 5.9 8.7 -2.5 -2.4 -2.5 -2.2 -2.3 -2.3 2.7 2.2 -2.8 -1.5 -2.7 -2.6 -1.8 -2.0 -2.4 -2.0 -2.4 -2.6 -2.5 -3.0 -2.7 -2.9 -1.8 -2.7 -2.5 -2.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.8 0.0 0.2 0.7 0.1 -0.3 0.3 -0.4 0.2 0.3 0.0 0.7 0.0 -0.4 -0.4 0.3 -0.9 0.2 0.3 0.1 0.2 0.5 0.2 0.4 -0.3 0.2 0.0
Mouth/teeth dental problems: Dentures 2.4 4.1 7.8 2.4 2.0 1.7 2.4 1.8 2.6 -1.9 -2.3 1.8 2.0 0.8 1.9 1.5 1.3 2.0 2.8 2.4 2.2 2.3 2.0 1.8 2.0 1.6 1.9 2.0 1.9
Asthma 1.5 3.0 7.4 1.6 1.8 0.4 1.5 2.4 2.3 -1.7 -1.6 1.3 2.7 1.1 1.5 2.3 1.6 2.0 1.5 1.5 1.5 1.7 1.4 1.6 1.3 2.5 1.4 1.4 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 2.1 -0.6 -0.1 0.2 -0.5 -0.0 -0.4 -0.0 0.3 -0.3 1.5 0.2 -0.1 0.4 -0.8 1.3 0.2 -0.7 -0.3 -0.5 -0.2 0.0 -0.6 -0.3 -0.5 0.0 0.6
Medication: Cholesterol lowering 0.3 0.4 3.3 0.0 0.5 1.8 0.2 0.3 0.0 -0.0 -0.2 0.7 1.5 1.0 0.2 0.2 -0.7 0.6 -0.8 0.4 0.5 0.5 0.4 0.7 0.4 0.2 0.5 0.2 0.2
Depression (self-reported) 0.2 0.2 0.5 0.5 0.6 0.6 0.5 -0.1 0.3 -0.4 -0.7 0.6 0.5 0.3 0.2 0.2 0.1 0.4 0.1 0.5 0.5 0.4 0.3 0.4 0.6 -0.4 0.7 0.2 0.0
Medication: Lansoprazole 0.3 0.4 1.5 -0.6 -0.2 -1.2 -1.0 -0.0 -1.0 0.9 0.6 -0.2 0.3 0.5 -0.9 0.4 0.7 -0.2 0.2 -0.9 -0.5 -0.6 -0.3 -0.8 -0.4 -0.5 0.4 0.7 0.6
Prospective memory result 0.9 1.1 2.7 1.2 0.4 1.6 1.0 0.4 1.3 -1.4 -0.7 0.4 1.6 -0.1 0.7 0.5 1.1 1.4 1.3 1.1 0.8 0.8 0.7 1.1 0.7 1.4 1.3 1.0 0.8
Lung cancer (father) 0.2 0.2 1.4 0.6 0.5 0.3 0.6 -0.1 0.3 -0.7 -0.8 0.1 0.4 -0.3 0.4 -0.1 0.1 0.6 -0.1 0.5 0.3 0.3 0.3 0.2 0.2 -1.2 0.2 0.8 0.0
Illnesses of mother 4.1 5.1 7.3 -2.4 -2.7 -2.3 -2.5 -1.9 -2.0 2.7 2.7 -2.6 -1.4 -2.3 -2.7 -1.9 -0.7 -2.4 -1.0 -2.6 -2.6 -2.5 -2.5 -2.7 -2.5 -0.4 -2.2 -2.0 -2.1
Forced expiratory volume in 1-second (FEV1), Best measure 7.3 23.2 46.9 -5.8 -3.5 -3.5 -5.4 -5.2 -6.8 5.8 4.8 -3.1 -6.1 -0.9 -4.6 -4.0 -4.4 -6.0 -5.9 -5.4 -4.2 -5.0 -3.7 -4.4 -3.9 -4.8 -4.8 -4.7 -4.7
Pulse wave Arterial Stiffness index 3.9 4.6 8.3 -2.4 -2.1 -2.3 -2.1 -1.1 -1.9 1.5 1.7 -2.3 -1.6 -2.3 -2.2 -1.5 -2.3 -1.9 -2.2 -2.1 -2.2 -2.3 -2.4 -2.0 -2.0 -2.6 -2.4 -2.9 -2.5
Impedance of arm (left) 11.9 55.2 110.2 -8.3 -5.5 -6.3 -8.3 -7.5 -10.5 9.5 7.5 -5.3 -10.5 -1.8 -7.6 -7.5 -3.8 -9.2 -8.7 -7.8 -7.0 -7.8 -6.0 -8.4 -6.4 -6.1 -6.1 -5.3 -8.0
Arm fat mass (right) 1.3 5.4 18.9 -3.2 -0.9 -3.0 -2.2 -1.2 -2.7 1.9 1.3 -1.1 -0.5 -0.0 -2.3 -1.6 -4.3 -1.0 -3.4 -2.2 -1.7 -2.0 -2.2 -2.2 -1.2 -4.3 -2.8 -2.4 -2.3
Trunk predicted mass 0.9 5.4 14.8 -2.9 -1.8 -2.0 -2.2 -2.4 -2.4 1.6 2.0 -1.9 -0.9 -1.5 -2.8 -1.4 -3.8 -1.3 -2.6 -2.3 -2.1 -2.3 -2.4 -1.7 -1.7 -3.3 -2.9 -3.2 -2.3
Standing height 13.9 138.3 239.5 -13.8 -9.6 -9.4 -12.9 -12.6 -15.5 13.4 11.9 -9.2 -14.0 -4.8 -12.6 -10.7 -9.8 -12.8 -13.3 -12.5 -11.1 -12.5 -10.5 -11.8 -10.3 -11.4 -10.9 -11.0 -12.8
Length of working week for main job 1.0 1.1 3.8 1.4 0.4 1.9 0.9 -0.8 1.3 -1.3 -0.6 0.6 0.6 0.1 0.7 0.7 1.5 1.0 1.0 0.8 0.8 0.7 1.1 1.0 0.8 1.8 1.0 1.1 0.8
Exposure to tobacco smoke at home 0.2 0.2 1.6 -0.1 -1.0 -0.3 -0.2 -0.1 -0.1 -0.0 0.3 -0.8 -0.2 -1.3 -0.4 -0.5 0.3 -0.2 0.7 -0.2 -0.6 -0.4 -0.6 -0.4 -0.3 -0.6 0.4 -0.1 -0.1
Breastfed as a baby 1.3 1.6 3.6 1.4 1.9 1.4 1.4 -0.6 1.2 -1.1 -1.4 1.6 0.1 1.6 0.6 0.1 0.8 1.0 0.2 1.6 1.5 1.3 1.4 1.2 1.3 1.4 1.8 1.5 0.7
Tense / ‘highly strung’ 1.4 2.3 3.8 1.9 1.6 1.8 1.8 1.0 1.9 -1.9 -1.4 1.6 1.7 1.2 1.6 0.9 1.4 1.5 1.2 1.9 1.6 1.8 1.4 1.4 1.6 1.7 0.7 1.3 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 4.0 6.5 1.9 1.7 1.8 1.5 1.9 2.0 -2.0 -1.4 2.3 1.4 2.3 1.8 2.0 2.1 1.8 2.1 1.7 2.1 2.0 2.4 1.9 2.0 2.0 2.5 2.1 2.4
Hair/balding pattern: Pattern 4 0.3 0.8 3.5 -0.8 0.5 -0.9 -0.4 -1.8 -0.9 0.7 0.0 0.8 0.0 1.5 -0.9 -1.5 -1.4 -0.4 -1.9 -0.4 0.2 -0.1 -0.1 -0.6 0.6 -1.6 -0.4 -0.0 0.1
Birth weight of first child 0.5 0.9 8.5 -0.4 0.8 -0.2 0.1 -1.1 0.0 -0.2 0.2 0.9 -0.8 1.4 -0.4 -2.2 -1.6 0.3 -2.9 0.2 0.5 0.3 0.1 0.2 0.5 -0.1 -0.7 -0.4 -0.5
Peak expiratory flow (PEF) 1.3 3.0 8.1 -1.9 -1.3 -0.5 -1.9 -2.9 -2.4 2.1 1.7 -1.4 -1.3 -0.6 -1.8 -1.3 -1.4 -1.7 -1.8 -2.1 -1.6 -1.8 -1.5 -1.6 -1.8 -1.7 -2.2 -1.4 -1.3
Pulse wave reflection index 0.8 0.9 3.2 -0.6 -0.7 -1.3 -0.3 -0.9 -0.0 -0.2 -0.1 -1.0 -0.2 -1.5 -0.8 -0.6 -1.8 -0.3 -1.1 -0.5 -0.7 -0.7 -1.3 -0.6 -0.9 -1.7 -1.4 -1.4 -0.8
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.1 -1.1 -1.6 -0.4 -1.0 -0.1 -0.9 0.6 1.1 -1.7 0.6 -1.8 -1.2 -0.5 -0.9 -0.4 0.4 -1.0 -1.4 -1.1 -1.4 -0.9 -1.5 -0.9 -0.2 -1.1 -0.7
Loud music exposure frequency 0.3 0.3 1.1 0.6 0.1 -0.2 0.4 -0.2 0.7 -0.4 -0.4 0.2 -0.0 0.1 0.6 0.5 1.0 -0.0 1.0 0.3 0.3 0.5 0.4 0.3 0.3 1.0 0.6 0.8 0.8
Qualifications: O levels/GCSEs or equivalent 2.9 4.6 11.5 -1.8 -2.9 -1.3 -1.6 -2.0 -1.2 1.4 2.3 -2.9 -0.9 -3.4 -1.9 -2.0 -1.7 -1.5 -1.8 -1.9 -2.4 -2.2 -2.8 -1.8 -2.9 -1.1 -2.6 -2.7 -2.6
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.6 -0.3 -1.3 0.1 -0.3 -0.3 -0.3 0.0 0.7 -1.0 -0.7 -1.2 0.2 -0.7 -0.4 -0.3 -0.3 -0.5 -0.8 -0.4 -0.7 -0.3 -0.9 -0.3 -0.4 -0.5 -0.3
Blood clot in the leg (DVT) 1.8 2.4 8.3 1.0 0.9 2.3 0.5 1.6 0.8 -0.5 -0.0 1.5 1.0 2.0 1.0 -0.0 2.0 1.2 1.7 0.8 1.2 1.1 1.9 1.2 1.4 2.7 2.9 2.1 2.0
Medication: Paracetamol 0.3 0.5 2.5 -0.0 -0.1 1.1 0.1 1.3 0.1 -0.5 -0.1 -0.0 1.6 -0.1 0.6 0.3 -1.1 1.5 0.6 0.0 0.1 0.1 0.0 0.5 -0.4 -0.7 0.5 0.8 0.6
Headache pain in last month 0.3 0.4 2.6 -0.8 -0.2 -0.0 -0.7 1.6 -0.4 0.5 0.7 -0.3 1.6 0.2 -0.1 -0.1 -0.4 -0.1 -1.2 -0.6 -0.5 -0.4 -0.4 -0.4 -0.2 0.4 -1.0 -0.6 -0.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.6 0.9 0.3 -0.5 0.4 -0.7 0.6 -0.5 -0.4 0.4 -0.9 0.2 0.4 0.5 1.5 -0.2 1.6 0.3 0.5 0.3 0.7 0.1 0.3 0.6 0.8 1.0 0.9
Glaucoma (self-reported) 0.2 0.2 1.1 0.2 0.1 0.1 0.4 1.1 0.5 -0.7 -0.6 0.1 0.7 -0.3 0.3 0.3 -0.6 0.8 0.1 0.4 0.2 0.2 -0.1 0.2 0.2 -0.8 0.0 0.0 -0.1
Gout (self-reported) 2.1 2.8 4.4 -1.8 -1.9 -0.8 -1.7 -1.5 -1.7 1.5 2.0 -1.9 -1.2 -1.6 -1.5 -1.9 -1.4 -1.3 -2.1 -1.8 -1.9 -1.8 -1.8 -1.4 -2.0 -0.7 -2.0 -1.6 -1.9
Hypothyroidism/myxoedema (self-reported) 3.4 6.6 12.9 -2.9 -2.5 -2.1 -2.7 -2.2 -3.0 2.9 2.6 -2.7 -2.0 -2.1 -2.9 -1.7 -2.0 -2.7 -1.1 -2.7 -2.9 -3.1 -2.7 -3.1 -2.6 -2.7 -2.1 -2.2 -3.6
Medication: Amlodipine 0.4 0.6 3.6 0.1 0.9 0.0 0.8 1.1 0.6 -0.3 -0.8 0.6 1.4 0.3 0.3 0.2 -1.9 0.7 -0.6 0.9 0.7 0.7 0.1 0.7 0.9 -0.5 -0.6 -0.9 -0.1
Medication: Ventolin 100micrograms inhaler 2.9 3.7 10.4 1.7 1.8 1.4 1.8 2.5 1.9 -1.9 -1.7 1.7 3.2 1.3 1.6 2.5 1.1 2.9 2.4 1.9 1.8 1.8 1.6 2.0 1.7 1.8 1.6 1.4 1.8
Birth weight 0.5 1.0 3.5 0.9 0.4 1.5 0.7 1.4 0.9 -0.7 -0.5 0.5 1.9 0.1 0.7 1.0 1.3 1.3 1.4 0.9 0.6 0.5 0.7 0.8 0.7 1.6 1.1 0.7 0.2
Chronic bronchitis/emphysema (mother) 2.3 2.7 5.5 1.9 1.0 2.3 1.4 1.3 1.5 -1.7 -0.8 1.4 1.3 1.2 1.6 0.7 2.3 2.2 1.6 1.6 1.4 1.5 1.8 1.6 1.3 2.0 2.1 2.1 1.6
High blood pressure (siblings) 0.2 0.2 1.1 -0.3 0.2 -0.8 0.1 0.6 -0.3 -0.0 -0.3 -0.2 -0.0 -0.3 0.1 1.0 -0.6 -0.4 -1.0 -0.0 -0.3 0.1 -0.4 -0.2 -0.2 -0.4 -0.9 -0.5 -0.7
Forced vital capacity (FVC), Best measure 4.4 16.0 37.2 -4.7 -3.1 -3.1 -4.8 -4.3 -5.9 5.2 4.4 -2.5 -6.1 -0.4 -3.8 -3.7 -2.3 -5.6 -4.4 -4.7 -3.5 -4.2 -2.7 -3.7 -3.3 -3.0 -3.3 -3.1 -3.3
Body fat percentage 5.6 22.3 47.3 -6.2 -2.4 -5.2 -5.2 -3.4 -6.5 5.2 3.9 -2.5 -4.0 0.0 -5.0 -4.4 -5.8 -4.0 -6.9 -4.9 -4.0 -4.6 -4.1 -5.1 -3.2 -6.5 -4.7 -4.1 -5.0
Leg fat percentage (right) 2.6 9.5 28.1 -4.3 -0.8 -3.8 -3.3 -1.3 -4.5 3.1 2.0 -1.0 -2.3 1.0 -2.9 -2.3 -4.5 -2.0 -5.2 -3.0 -2.2 -2.7 -2.4 -3.1 -1.5 -5.3 -3.1 -2.6 -3.2
Arm fat-free mass (right) 1.0 5.3 15.4 -3.1 -1.6 -1.9 -2.4 -2.4 -2.5 1.7 2.0 -1.6 -0.7 -0.9 -2.8 -1.5 -3.9 -1.1 -2.9 -2.4 -1.9 -2.4 -2.3 -1.7 -1.6 -3.3 -2.7 -2.9 -2.3
Exposure to tobacco smoke outside home 0.7 0.9 4.0 -0.6 -1.6 -0.6 -1.0 -0.1 -0.7 0.4 0.9 -1.6 -0.2 -2.0 -0.9 -0.4 0.7 -0.6 0.5 -1.1 -1.4 -1.2 -1.0 -1.0 -1.3 -0.3 0.0 -0.2 -0.7
Comparative body size at age 10 1.6 4.3 12.4 2.2 1.4 1.1 1.6 1.7 2.3 -2.2 -1.5 1.4 3.5 1.2 1.9 0.1 2.7 2.5 2.2 1.4 1.6 1.7 1.8 1.7 1.5 2.5 2.4 3.0 3.2
Number of full brothers 2.9 3.7 7.6 2.3 1.8 1.6 2.2 1.9 2.3 -2.6 -2.1 1.8 0.3 1.3 2.8 1.4 1.1 1.9 0.9 1.9 2.0 2.2 2.1 2.2 1.9 1.7 1.6 2.0 2.1
Worry too long after embarrassment 4.2 7.0 10.2 -3.0 -2.3 -2.7 -2.9 -3.0 -3.0 2.9 2.3 -2.6 -1.5 -1.8 -3.2 -2.0 -2.4 -2.5 -2.8 -3.0 -2.8 -2.8 -2.8 -3.1 -3.2 -2.9 -2.6 -2.1 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 7.3 1.6 1.1 1.1 1.1 0.3 1.5 -1.4 -0.8 1.6 0.7 1.5 0.9 0.5 2.4 1.0 2.7 1.2 1.5 1.3 1.8 1.2 1.5 2.4 2.4 2.1 2.0
Wheeze or whistling in the chest in last year 2.1 3.8 7.4 1.5 2.4 0.8 1.5 2.7 1.9 -1.9 -1.8 2.2 2.7 2.4 1.3 2.7 0.9 2.4 1.5 1.7 2.0 2.0 2.0 1.8 2.3 1.6 1.5 1.5 2.1
Number of children fathered 4.3 4.9 8.4 2.6 2.1 2.3 2.2 1.5 2.3 -1.7 -2.0 2.3 1.7 1.9 2.5 2.0 2.2 2.1 2.9 2.3 2.4 2.3 2.5 2.1 2.4 1.6 2.2 2.5 2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.6 1.4 1.4 0.9 1.3 -0.8 1.1 -0.9 -1.2 1.6 0.4 1.4 0.7 -0.3 0.9 1.0 1.4 1.3 1.5 1.2 1.3 0.8 1.4 0.3 1.4 1.4 1.4
Age at first live birth 3.0 5.4 10.8 -2.4 -2.3 -2.1 -2.5 -2.3 -2.7 2.8 2.2 -2.5 -2.8 -2.0 -2.5 -2.0 -0.9 -3.3 -2.0 -2.4 -2.6 -2.5 -2.5 -2.6 -2.2 -1.6 -1.5 -1.6 -2.3
Pulse wave peak to peak time 1.3 1.5 3.9 1.3 1.2 1.5 1.1 0.1 0.8 -0.5 -0.9 1.5 0.6 1.8 1.2 0.8 1.5 0.9 1.1 1.2 1.3 1.2 1.5 1.0 1.1 1.6 1.4 2.0 1.3
Health satisfaction 0.9 1.2 3.5 0.5 1.1 1.3 0.6 1.6 0.7 -0.9 -0.7 1.2 1.6 1.4 0.8 0.4 -0.2 1.4 0.4 0.7 1.0 1.0 1.0 0.9 1.1 0.5 1.4 1.4 1.9
Shortness of breath walking on level ground 0.9 1.1 3.6 -1.4 -0.5 -0.7 -1.5 0.3 -1.5 1.6 1.7 -0.4 -0.0 0.6 -1.2 -1.7 -0.1 -0.8 -1.9 -1.3 -0.9 -0.9 -0.6 -1.2 -0.5 0.4 -0.9 -0.5 -0.6
Qualifications: College or University degree 0.5 1.5 5.9 -1.4 -0.7 -1.8 -1.3 -1.3 -1.4 1.6 1.1 -0.8 -2.0 -0.1 -1.2 -1.2 -0.8 -2.4 -1.1 -1.3 -1.0 -1.1 -1.0 -1.2 -0.9 -0.5 -0.6 -0.7 -0.6
Eye problems/disorders: None of the above 0.6 0.7 3.9 -0.8 -0.6 0.1 -0.8 -1.5 -0.8 0.6 1.0 -0.6 -1.0 -0.0 -0.7 -0.4 -0.7 -0.6 -2.0 -1.0 -0.6 -0.6 -0.5 -0.3 -0.7 0.7 -1.5 -1.0 -0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.0 4.1 1.0 0.4 1.2 0.8 2.0 0.4 -0.3 -0.5 0.7 0.9 0.5 1.3 0.2 1.0 0.6 1.9 1.0 0.7 0.9 1.0 0.8 0.9 0.8 1.7 0.9 1.0
Emphysema/chronic bronchitis 2.2 2.4 5.0 1.5 1.5 1.1 1.2 2.2 1.3 -1.2 -1.1 1.6 1.6 1.3 1.4 1.0 1.8 1.6 2.2 1.4 1.4 1.6 1.7 1.2 1.4 1.8 1.8 1.6 2.0
Medication for pain relief, constipation, heartburn 0.2 0.3 1.8 0.4 0.3 -0.4 0.2 -0.1 0.3 0.1 -0.2 0.3 -0.9 0.2 -0.1 0.2 1.3 -1.4 0.0 0.4 0.3 0.3 0.4 -0.2 0.7 0.9 0.3 -0.0 -0.2
Neck or shoulder pain in last month 1.2 1.7 3.1 1.1 1.5 1.0 1.2 1.1 1.1 -1.0 -1.2 1.8 0.4 1.7 1.3 0.5 0.4 1.1 1.0 1.3 1.6 1.6 1.6 1.4 1.5 0.7 1.7 1.2 1.7
Medication: Blood pressure 0.8 1.4 5.0 -1.5 -0.9 -0.7 -1.1 0.5 -1.4 1.1 1.1 -1.0 0.8 -0.6 -1.1 -1.1 -1.7 -0.4 -2.2 -1.0 -1.2 -0.9 -1.3 -1.0 -0.9 -1.4 -1.5 -1.5 -1.4
Angina (self-reported) 0.2 0.3 1.5 -0.1 -0.8 1.1 -0.5 0.8 -0.6 0.4 0.7 -0.1 0.4 0.2 0.1 0.1 1.2 -0.1 0.6 -0.3 -0.3 -0.2 0.2 0.1 0.1 1.2 0.9 0.3 0.3
Migraine (self-reported) 1.1 1.4 3.8 0.5 1.4 1.3 0.5 1.4 0.6 -0.7 -0.6 1.3 1.9 1.9 1.0 0.6 0.6 1.3 -0.1 0.7 1.1 1.1 1.2 1.2 1.0 1.9 1.0 1.4 1.5
Medication: Ibuprofen 0.4 0.5 4.2 -0.4 0.5 0.6 -0.3 0.3 -0.2 -0.4 0.0 0.4 2.1 1.1 -0.0 0.8 -0.6 2.0 0.3 -0.4 0.2 -0.1 0.3 0.4 -0.1 -0.0 -0.0 0.4 0.8
Medication: Allopurinol 1.4 1.9 4.6 -1.5 -1.7 0.4 -1.6 -1.0 -1.4 1.3 2.2 -1.4 -0.3 -1.0 -1.4 -1.7 -0.9 -0.8 -1.4 -1.5 -1.5 -1.5 -1.3 -1.0 -1.7 0.5 -1.4 -1.5 -1.8
Medication: Omeprazole 0.7 0.9 5.0 -1.1 -0.1 -0.6 -0.7 -0.7 -0.8 1.0 0.7 -0.2 0.6 0.2 -0.7 -1.6 -1.5 -0.5 -2.2 -0.6 -0.5 -0.7 -0.7 -0.8 -0.2 -0.6 -1.4 -1.0 -1.4
Medication: Seretide 50 evohaler 0.9 1.0 2.9 1.0 0.9 0.2 0.7 1.2 0.8 -0.5 -0.9 0.9 0.9 0.9 0.9 1.2 1.7 0.8 1.4 0.9 1.0 0.8 1.0 0.5 1.2 0.9 1.3 1.4 1.3
Mean time to correctly identify matches 1.2 2.2 4.7 1.6 1.7 0.4 1.4 1.2 1.3 -0.9 -1.4 1.8 -0.5 1.6 1.5 0.7 2.0 0.3 1.6 1.5 1.6 1.7 1.8 1.0 1.9 1.7 2.0 1.6 2.2
Heart disease (mother) 0.6 0.7 3.7 0.6 0.5 1.1 0.6 1.9 0.3 -0.6 -0.5 0.8 0.8 0.9 1.3 1.3 0.1 0.9 0.7 0.7 0.7 0.8 0.9 1.0 0.7 -0.3 0.8 0.5 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.5 1.0 0.7 0.5 0.8 -0.6 1.0 -0.8 -0.8 0.4 0.3 0.3 0.5 0.5 1.0 0.7 1.0 0.5 0.6 0.7 0.5 0.5 0.4 1.0 0.9 1.2 0.9
Whole body fat mass 5.3 22.3 44.3 -6.2 -2.7 -5.2 -5.2 -3.5 -6.2 5.0 3.9 -2.9 -3.5 -0.7 -5.1 -4.1 -6.2 -3.8 -6.5 -4.9 -4.1 -4.7 -4.4 -5.0 -3.4 -6.7 -4.8 -4.5 -5.1
Leg fat mass (right) 2.8 11.0 30.7 -4.5 -1.4 -3.8 -3.5 -2.1 -4.4 3.2 2.3 -1.6 -2.1 0.1 -3.3 -2.3 -5.3 -2.1 -5.2 -3.3 -2.6 -3.1 -3.0 -3.2 -1.9 -5.5 -3.6 -3.3 -3.5
Arm predicted mass (right) 1.1 5.5 16.3 -3.1 -1.7 -2.0 -2.4 -2.3 -2.5 1.7 2.0 -1.7 -0.8 -1.1 -2.8 -1.4 -4.0 -1.1 -2.9 -2.4 -2.0 -2.4 -2.4 -1.7 -1.8 -3.4 -2.8 -3.0 -2.3
Pulse rate, automated reading 2.6 8.3 14.4 3.3 3.0 2.0 3.6 3.5 3.8 -3.3 -3.5 2.6 2.2 1.4 3.5 2.6 1.1 3.2 2.2 3.8 3.0 3.5 2.5 3.1 3.0 1.8 2.7 2.3 2.1
Alcohol intake frequency. 2.1 4.9 13.2 1.8 2.1 2.2 1.9 3.6 2.0 -2.0 -1.7 2.3 3.3 2.1 2.7 2.1 0.7 2.8 1.3 2.0 2.2 2.3 2.4 2.3 2.1 1.6 1.8 2.1 2.1
Comparative height size at age 10 15.6 86.1 156.2 -10.8 -7.5 -7.8 -10.4 -9.8 -12.5 11.2 9.6 -7.5 -10.9 -3.7 -10.1 -8.7 -6.5 -10.4 -10.2 -10.1 -9.0 -10.0 -8.2 -10.0 -8.1 -7.9 -8.5 -8.0 -9.7
Number of full sisters 5.8 7.0 13.9 2.8 3.1 3.0 2.7 2.7 2.7 -3.0 -3.0 2.8 1.6 2.2 2.4 3.7 2.0 2.8 2.3 2.8 2.9 2.8 3.0 2.8 2.8 2.0 2.4 1.9 1.8
Suffer from ‘nerves’ 0.3 0.5 1.4 -0.9 -1.0 -0.6 -1.0 -0.5 -0.6 0.1 1.2 -0.7 -1.1 -0.4 -0.6 -0.8 -0.5 -0.5 -0.7 -1.0 -0.8 -0.9 -0.6 -0.5 -0.7 -0.3 -0.8 -0.7 -0.5
Overall health rating 0.3 0.6 4.3 0.0 0.7 0.4 0.2 2.1 0.1 -0.5 -0.2 0.8 1.6 0.9 0.5 0.1 -0.4 1.1 0.1 0.3 0.6 0.6 0.6 0.5 0.8 -0.1 0.8 0.7 1.1
Chest pain or discomfort 0.5 0.7 4.2 0.5 0.5 0.8 0.5 2.1 0.7 -0.4 -0.4 0.7 1.5 0.6 0.9 1.4 0.4 1.0 0.9 0.6 0.6 0.7 0.7 0.9 0.7 1.1 0.7 0.3 0.5
Had major operations 0.1 0.1 0.9 -0.3 -0.4 -0.0 -0.5 0.2 -0.4 0.3 0.6 -0.2 0.2 0.0 -0.4 -1.0 0.4 -0.0 -0.1 -0.5 -0.3 -0.5 -0.1 -0.5 -0.3 0.2 0.2 0.3 0.2
Age at last live birth 0.3 0.4 2.5 0.1 0.9 -0.0 0.5 -0.8 -0.1 -0.1 -0.8 0.6 -1.3 0.6 0.2 -0.6 -0.6 -0.9 -1.6 0.5 0.4 0.5 0.0 0.1 0.6 -0.8 0.0 0.2 -0.4
Family relationship satisfaction 1.8 2.2 5.6 1.3 1.9 1.1 1.2 1.0 1.2 -0.9 -1.4 2.2 0.3 2.4 1.1 1.1 1.3 0.9 0.9 1.5 1.9 1.6 2.0 1.1 2.0 1.1 1.6 1.6 1.5
Leg pain on walking 0.9 1.1 5.1 0.8 1.2 2.3 0.8 1.3 0.9 -0.7 -0.6 1.2 1.3 1.2 1.1 0.9 0.1 1.2 0.4 1.0 1.1 1.0 1.2 1.4 1.1 1.2 0.8 0.6 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 4.2 -0.4 -0.1 0.0 -0.4 -2.1 -0.5 0.3 0.6 0.0 -2.0 0.2 -0.6 -1.1 -0.5 -0.9 -1.4 -0.5 -0.1 -0.3 -0.2 -0.4 -0.3 -0.1 -1.2 -1.0 -1.0
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.7 -1.3 -1.3 -1.4 -1.6 -0.0 -1.5 1.0 1.3 -1.6 -0.4 -1.1 -1.0 -0.2 0.2 -0.8 0.5 -1.6 -1.5 -1.5 -1.1 -1.2 -1.6 -0.0 -0.5 -0.5 0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 2.2 0.9 0.7 -0.2 0.8 0.2 0.7 -0.4 -1.0 0.7 -0.3 0.1 0.6 0.5 1.0 0.3 1.5 0.8 0.7 0.6 0.7 0.2 0.6 0.0 0.5 0.2 0.5
Medication: Aspirin 0.2 0.3 2.0 0.5 0.1 1.4 0.3 0.8 0.1 -0.3 0.1 0.3 -0.1 0.2 0.8 -0.5 0.9 0.3 0.1 0.4 0.3 0.2 0.6 0.8 0.3 1.3 0.5 0.2 0.1
Supplements: Vitamin C 0.2 0.2 2.2 0.2 0.1 -0.3 0.2 -0.3 -0.0 0.1 0.1 -0.0 -1.2 -0.1 0.0 -1.5 0.0 -0.5 0.5 0.1 0.0 0.2 0.1 -0.0 -0.1 0.3 0.6 0.1 0.5
Knee pain experienced in last month 0.4 0.6 1.4 0.5 0.9 0.2 0.9 0.4 0.8 -0.8 -0.9 1.2 0.5 1.0 0.5 0.4 -0.8 1.1 0.7 0.9 1.1 0.8 0.7 1.0 0.7 -0.1 1.2 0.3 0.7
Hypertension (Self-reported) 0.6 1.6 8.1 -1.5 -0.9 -1.4 -0.8 -0.0 -1.0 0.5 0.6 -1.1 0.6 -1.2 -1.2 -1.1 -2.9 -0.3 -1.6 -0.9 -1.1 -0.9 -1.7 -1.0 -0.8 -2.3 -1.3 -1.7 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 1.2 -0.2 0.6 -0.6 0.0 0.3 -0.1 -0.0 -0.1 0.7 -0.4 1.1 0.2 -0.0 -0.5 0.5 -0.6 0.2 0.4 0.2 0.3 0.3 0.6 -0.2 0.1 0.2 0.2
Illnesses of father: Heart disease 0.7 1.0 4.8 0.6 0.8 2.2 0.4 0.7 0.4 -0.5 -0.2 1.0 2.2 1.3 0.4 1.0 0.6 1.6 0.7 0.4 0.8 0.5 1.1 0.7 0.6 1.3 0.4 0.8 0.7
Illnesses of siblings: Diabetes 0.8 1.0 2.4 -1.2 -0.8 -1.2 -1.5 -0.9 -1.6 1.4 1.1 -0.6 -1.1 0.2 -1.0 -0.0 0.6 -1.4 -0.2 -1.5 -1.0 -1.2 -0.5 -1.3 -1.0 -0.0 -0.6 -0.1 -0.6
Smoking status: Previous 0.3 0.4 2.1 -0.5 -0.0 -0.9 -0.5 -1.4 -0.4 0.6 -0.0 -0.2 -0.1 0.1 -1.1 -0.8 -0.4 -0.5 -0.0 -0.5 -0.3 -0.7 -0.5 -1.0 -0.3 -1.0 0.2 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 15.0 31.2 46.7 -6.4 -5.7 -4.2 -6.2 -4.4 -6.8 6.3 6.1 -5.5 -5.1 -4.2 -5.7 -4.5 -4.2 -5.9 -5.4 -6.2 -6.0 -6.1 -5.5 -5.7 -5.9 -4.7 -5.6 -5.6 -6.1
Whole body fat-free mass 0.9 4.9 15.2 -2.8 -1.8 -1.9 -2.1 -2.2 -2.0 1.4 1.8 -1.9 -0.5 -1.6 -2.6 -1.3 -3.9 -1.0 -2.4 -2.2 -2.0 -2.2 -2.4 -1.6 -1.7 -3.1 -2.9 -3.2 -2.2
Leg fat-free mass (right) 0.5 2.6 10.0 -2.0 -1.6 -1.5 -1.4 -1.4 -0.9 0.8 1.4 -1.5 0.4 -1.5 -1.9 -0.9 -3.2 -0.3 -1.2 -1.6 -1.4 -1.5 -1.9 -1.0 -1.3 -2.0 -2.1 -2.6 -1.5
Arm fat percentage (left) 1.3 5.1 14.3 -3.1 -0.7 -3.1 -2.3 -0.9 -2.8 2.2 1.4 -0.9 -0.8 0.2 -2.3 -1.8 -3.8 -1.2 -3.5 -2.2 -1.7 -2.0 -2.1 -2.4 -1.2 -3.8 -2.6 -2.1 -2.3
Average weekly red wine intake 1.2 1.7 4.9 -1.7 -0.8 -2.2 -1.3 -1.4 -1.3 1.3 1.0 -0.6 0.2 -0.1 -2.0 -1.4 -1.6 -1.3 -1.4 -1.2 -1.0 -1.2 -1.4 -1.5 -0.8 -1.9 -1.1 -1.1 -1.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 2.7 0.0 -0.0 -0.4 -0.0 -1.0 -0.4 0.3 0.1 -0.1 -1.6 -0.0 0.0 -0.4 0.1 -0.7 0.3 -0.0 -0.1 -0.2 0.1 0.1 -0.1 0.2 0.0 -0.3 -0.3
Mood swings 0.5 0.9 2.9 0.6 0.9 0.8 0.5 0.8 0.6 -0.7 -0.6 1.3 0.5 1.6 0.6 0.4 0.5 0.9 0.4 0.6 1.0 0.9 1.2 0.6 1.1 -0.3 1.5 1.7 1.7
Loneliness, isolation 0.3 0.4 1.5 0.5 0.2 0.3 0.3 0.5 0.2 -0.3 -0.0 0.7 -0.5 0.8 0.9 -0.6 0.6 0.2 0.3 0.2 0.6 0.5 1.0 0.4 0.5 0.2 1.0 1.2 1.1
Long-standing illness, disability or infirmity 0.5 0.8 2.0 0.9 0.9 1.2 1.1 1.4 1.0 -0.8 -1.1 0.8 1.2 0.4 1.3 0.8 -0.2 1.1 0.3 1.1 0.9 1.1 0.9 1.1 0.7 0.1 0.7 0.2 0.7
Ever had bowel cancer screening 0.2 0.3 1.8 0.5 0.5 -0.1 0.2 0.3 0.2 0.4 -0.3 0.5 -1.0 0.7 0.4 -0.3 1.3 -0.5 0.7 0.2 0.3 0.5 0.6 -0.4 0.6 0.2 0.5 0.7 0.3
Diabetes diagnosed by doctor 0.8 1.2 2.7 -1.3 -1.2 -0.6 -1.2 -1.6 -1.4 1.1 1.2 -1.1 -0.9 -0.9 -1.4 -1.2 -0.8 -0.6 -0.6 -1.3 -1.2 -1.2 -1.0 -1.1 -1.1 -1.4 -0.8 -0.9 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 3.5 1.3 1.2 0.6 1.0 -0.0 0.7 -0.7 -1.0 0.9 -0.7 0.6 1.0 0.4 1.9 0.5 0.3 1.0 0.9 1.0 1.1 0.7 1.0 1.3 0.5 1.0 0.9
Friendships satisfaction 0.6 0.7 1.7 -1.0 -0.7 -1.3 -1.1 -0.3 -1.1 1.1 1.1 -0.4 -1.0 0.0 -1.0 -1.2 0.1 -1.1 -0.8 -1.0 -0.7 -0.8 -0.4 -1.1 -0.3 -0.4 -0.6 -0.4 -0.7
Qualifications: nursing, teaching 3.3 5.2 10.2 -2.6 -1.8 -2.1 -2.8 -2.2 -3.1 3.2 2.6 -2.1 -1.8 -0.9 -2.8 -2.9 -0.4 -2.6 -1.6 -2.8 -2.5 -2.7 -2.1 -2.9 -2.2 -1.1 -1.3 -1.3 -1.9
Commuting to job workplace: Walk 2.3 2.4 5.8 1.9 1.7 0.7 2.4 1.2 2.3 -2.0 -2.2 1.6 -0.3 0.6 1.9 1.1 -0.3 1.6 1.1 2.3 1.9 2.1 1.4 1.9 1.7 0.3 0.8 0.4 0.4
Eye problems/disorders: Cataract 0.9 1.1 2.6 -1.1 -1.1 -1.6 -1.1 0.7 -1.1 1.3 0.8 -1.2 0.1 -1.2 -1.1 -0.4 -0.4 -0.5 1.3 -1.0 -1.2 -1.3 -1.3 -1.3 -1.3 -1.4 0.1 -0.6 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.0 1.7 5.1 1.5 1.2 1.1 1.7 0.9 1.6 -2.0 -1.7 1.0 1.9 0.3 1.3 0.9 -0.2 2.3 1.0 1.5 1.3 1.6 0.9 1.4 1.0 -0.2 0.4 0.8 1.0
Medication for cholesterol 0.1 0.1 0.6 0.4 0.0 0.4 0.1 -0.5 0.3 -0.1 0.1 0.1 -0.6 0.1 0.4 -0.1 0.8 -0.2 0.0 -0.0 0.1 0.1 0.3 0.1 -0.2 0.7 -0.2 0.2 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 5.9 1.9 1.5 2.3 1.6 1.1 1.8 -1.2 -1.2 1.9 1.1 1.9 2.0 0.6 1.8 1.6 0.3 1.4 1.8 1.8 2.2 1.6 1.8 2.4 1.5 2.1 1.9
Back pain experienced in last month 0.8 1.1 3.3 -1.5 -1.3 -0.9 -1.8 -1.2 -1.6 1.1 1.7 -0.5 -0.8 0.4 -1.4 -1.4 -0.1 -0.8 0.0 -1.8 -0.9 -1.3 -0.5 -1.0 -1.0 -0.4 0.2 -0.1 0.3
Mineral and other dietary supplements 1.1 1.4 2.8 1.1 1.7 1.2 1.1 0.1 1.1 -1.6 -1.4 1.4 1.5 1.5 1.0 0.7 0.9 1.4 -0.6 1.0 1.3 1.3 1.2 1.2 1.5 0.8 0.6 1.3 1.4
Breast cancer (self-reported) 0.2 0.3 2.0 0.2 -0.7 0.1 0.3 1.0 0.6 0.0 -0.1 -0.7 0.1 -1.4 0.4 0.5 -0.3 -0.1 0.0 0.3 -0.2 -0.2 -0.5 -0.1 -0.0 -0.7 -0.6 -0.6 -1.0
Asthma (self-reported) 1.6 3.1 6.5 1.8 1.9 0.4 1.6 2.1 2.4 -1.7 -1.7 1.5 2.5 1.2 1.6 2.2 1.6 1.9 1.2 1.6 1.6 1.8 1.5 1.6 1.4 2.5 1.4 1.5 2.0
Osteoporosis (self-reported) 0.1 0.1 0.6 0.1 0.2 -0.1 0.2 -0.3 -0.0 -0.2 -0.2 -0.3 0.1 -0.5 -0.1 0.6 -0.2 0.5 -0.0 0.1 -0.1 -0.2 -0.3 0.0 -0.7 -0.4 -0.7 -0.5 -0.7
Osteoarthritis (self-reported) 0.2 0.2 1.0 -0.1 -0.1 -0.9 -0.1 -0.1 0.2 0.3 0.2 0.4 -1.0 0.7 0.5 -0.3 -0.2 -0.7 0.7 -0.2 0.3 0.2 0.4 0.1 0.0 0.2 0.5 0.7 1.0
Medication: Aspirin 0.1 0.2 1.4 0.4 -0.3 1.2 0.2 0.7 -0.0 -0.4 0.2 -0.1 -0.1 -0.3 0.6 -0.6 0.7 0.2 0.2 0.2 -0.0 0.0 0.2 0.5 0.0 0.9 0.4 0.1 -0.1
Medication: Gliclazide 0.2 0.2 1.4 0.2 0.2 -0.0 -0.2 -0.6 -0.2 -0.2 0.1 0.1 -0.7 0.4 0.0 0.6 1.2 0.3 0.2 -0.1 -0.1 0.1 0.3 0.4 -0.4 1.0 0.5 0.8 0.7
Illnesses of father: None of the above (group 1) 0.2 0.2 1.0 0.0 -0.6 0.2 -0.2 0.6 -0.1 0.0 0.4 -0.7 -0.2 -1.0 0.2 -1.0 0.5 -0.3 0.2 -0.1 -0.5 -0.3 -0.3 -0.1 -0.4 0.3 -0.2 -0.3 -0.7
Smoking status: Current 0.2 0.4 1.8 0.3 0.5 0.9 0.3 0.4 0.1 -0.7 -0.0 0.7 1.4 0.9 0.2 0.3 0.5 1.3 -0.0 0.4 0.5 0.5 0.6 0.7 0.8 0.7 0.1 0.2 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 3.0 -0.8 -0.0 -0.2 -0.4 -1.2 -1.1 0.8 0.3 0.2 -1.1 0.5 -0.3 -1.2 -1.7 -1.0 -1.7 -0.4 -0.0 -0.4 -0.2 -0.1 -0.0 -1.5 -0.8 -0.8 -0.3
Whole body water mass 0.8 4.6 14.5 -2.7 -1.8 -1.9 -2.0 -2.1 -2.0 1.4 1.8 -1.9 -0.4 -1.5 -2.6 -1.2 -3.8 -1.0 -2.3 -2.1 -1.9 -2.1 -2.4 -1.5 -1.7 -3.0 -2.8 -3.1 -2.1
Leg predicted mass (right) 0.5 2.5 9.7 -2.0 -1.5 -1.5 -1.4 -1.4 -0.9 0.8 1.4 -1.5 0.4 -1.5 -1.9 -0.8 -3.1 -0.3 -1.2 -1.6 -1.4 -1.5 -1.9 -1.0 -1.3 -2.0 -2.1 -2.5 -1.4
Arm fat mass (left) 1.6 6.5 20.4 -3.5 -1.1 -3.3 -2.5 -1.4 -3.0 2.3 1.6 -1.3 -0.6 -0.2 -2.6 -1.7 -4.5 -1.2 -3.6 -2.5 -2.0 -2.3 -2.5 -2.5 -1.5 -4.5 -3.0 -2.6 -2.6
Number of self-reported non-cancer illnesses 0.1 0.2 2.3 -0.5 0.0 0.0 -0.2 0.7 -0.0 0.1 0.2 0.0 1.5 0.1 -0.2 -0.6 -1.1 0.8 -0.4 -0.2 -0.1 -0.1 -0.3 0.1 -0.1 -0.0 0.3 -0.0 0.1
Average weekly champagne plus white wine intake 2.8 3.8 8.7 -1.6 -1.9 -1.7 -1.6 -2.7 -1.9 2.1 1.7 -2.0 -2.5 -1.7 -1.8 -3.0 -1.2 -2.6 -1.6 -1.7 -1.9 -1.8 -2.0 -2.2 -1.9 -1.5 -1.4 -1.2 -2.0
Miserableness 0.1 0.3 1.3 0.2 0.2 0.6 -0.1 0.3 0.2 -0.5 -0.0 0.3 0.3 0.5 0.2 0.1 0.4 0.9 0.8 -0.1 0.3 -0.0 0.6 0.4 -0.1 0.3 1.0 0.8 1.1
Guilty feelings 0.7 1.0 2.4 -1.3 -0.9 -0.9 -1.5 -0.9 -1.4 1.5 1.2 -0.7 -0.2 -0.1 -1.3 -1.0 -0.7 -0.3 -0.3 -1.5 -1.0 -1.2 -0.8 -1.4 -1.3 -0.7 -0.3 -0.4 0.2
Wears glasses or contact lenses 0.1 0.1 1.4 -0.0 -0.1 -0.5 0.0 -0.4 -0.1 0.4 -0.1 -0.0 -0.4 -0.2 -0.1 -0.4 -0.2 -0.3 0.1 0.0 0.0 -0.1 -0.1 -0.3 -0.0 -1.2 0.3 0.1 -0.0
Ever taken oral contraceptive pill 0.1 0.1 1.0 -0.1 -0.4 0.1 -0.1 -0.6 -0.1 0.4 0.1 -0.1 -0.6 -0.3 -0.3 0.1 -0.0 -0.6 -0.3 -0.1 -0.1 -0.2 -0.3 -0.4 0.0 -1.0 0.1 0.1 -0.6
Hearing aid user 0.4 0.5 2.7 -0.5 0.3 -1.0 -0.0 -1.3 -0.2 -0.3 -0.2 0.2 0.9 0.4 -0.7 -0.6 -1.6 0.9 -0.8 -0.1 0.2 -0.1 -0.3 0.3 -0.1 -1.6 -0.3 -0.3 0.1
Mother’s age at death 0.2 0.3 2.4 0.1 0.2 0.1 0.0 -1.1 -0.2 -0.1 -0.0 0.4 -1.6 0.6 -0.1 -0.8 0.3 -0.2 0.5 0.2 0.3 0.1 0.3 0.3 0.5 0.6 1.0 0.3 0.4
Financial situation satisfaction 0.3 0.4 1.6 -0.5 -0.6 0.2 -0.9 0.4 -0.8 0.8 1.3 -0.4 0.2 -0.1 -0.6 -0.6 1.2 -0.3 -0.5 -0.8 -0.7 -0.6 -0.2 -0.6 -0.2 1.1 -0.2 -0.2 -0.1
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.8 0.8 1.2 0.4 1.4 0.9 1.2 -1.2 -1.5 0.9 0.9 0.3 0.6 1.4 -1.0 0.8 0.1 1.7 1.1 1.3 0.5 1.2 1.3 -0.9 -0.1 -0.7 -0.2
Commuting to job workplace: Public transport 0.5 0.6 1.5 0.8 0.3 1.2 0.7 0.7 0.8 -0.8 -0.6 0.6 0.8 0.6 0.9 -0.1 0.8 0.3 0.7 0.6 0.8 0.7 0.8 0.7 0.8 0.5 1.2 1.2 1.0
Eye problems/disorders: Glaucoma 0.6 0.8 2.7 0.9 0.7 0.5 1.1 0.9 1.1 -1.4 -1.4 0.5 1.3 -0.1 0.7 0.5 -0.3 1.6 0.7 1.1 0.7 0.7 0.3 0.8 0.7 -0.7 1.0 0.7 0.5
Medication: Blood pressure 0.6 1.1 4.2 -0.9 -1.3 -1.9 -0.4 -0.0 -0.6 0.5 0.3 -1.4 -0.3 -2.0 -0.9 -0.8 -1.8 -0.5 -0.3 -0.5 -1.1 -0.8 -1.6 -0.9 -0.9 -1.7 -0.6 -1.2 -0.4
Pain type(s) experienced in last month: Hip pain 0.8 1.1 5.3 -1.2 -0.9 -1.5 -0.7 -0.6 -0.7 0.7 0.6 -0.7 -0.8 -0.7 -0.7 -0.4 -2.3 -0.7 -0.5 -0.7 -0.7 -0.8 -1.0 -0.6 -1.0 -1.8 -1.2 -1.6 -1.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.8 -0.7 -1.6 -0.9 -0.8 0.0 -0.7 1.4 1.1 -1.3 -1.2 -1.6 -0.5 -0.2 -0.4 -1.4 1.7 -0.8 -1.1 -0.9 -1.0 -1.1 -1.3 -0.7 -0.3 -0.8 -0.7
High cholesterol (Self-reported) 0.3 0.6 1.7 0.7 0.6 1.3 0.5 0.8 0.4 -0.7 -0.5 0.7 1.2 0.6 0.4 0.6 0.6 1.0 0.6 0.6 0.7 0.7 0.8 0.9 0.6 0.1 1.1 0.7 1.3
Medication: Bendroflumethiazide 0.2 0.3 1.7 -0.1 -0.0 1.1 0.0 1.2 0.0 -0.4 0.2 0.1 1.3 -0.1 0.0 0.1 -0.4 0.9 -0.3 0.1 0.1 -0.0 0.2 0.4 0.3 0.3 -0.2 -0.4 -0.5
Medication: Paracetamol 0.3 0.5 2.8 -0.1 -0.2 0.9 -0.2 1.4 -0.2 -0.2 0.2 -0.0 1.7 0.1 0.5 0.3 -0.2 1.4 0.9 -0.3 -0.0 -0.1 0.2 0.4 -0.6 -0.2 0.9 1.1 0.8
Medication: Lisinopril 0.2 0.3 1.5 -0.9 -0.2 -0.9 -0.6 0.1 -0.6 0.4 -0.0 -0.3 -0.3 -0.2 -0.4 -0.1 -1.2 -0.2 -0.8 -0.6 -0.4 -0.5 -0.6 -0.3 -0.3 -1.2 -0.3 -0.7 -0.3
Medication: Atorvastatin 1.1 1.4 2.7 1.1 1.1 1.5 0.9 1.4 1.0 -0.6 -0.8 1.3 1.3 1.4 1.1 0.9 1.3 0.6 0.9 1.2 1.2 1.2 1.4 1.1 1.4 1.6 1.2 1.1 1.4
Illnesses of father: High blood pressure 1.7 2.1 5.0 -1.6 -1.4 -1.6 -1.6 -1.8 -1.7 1.7 1.0 -1.4 -0.7 -1.0 -1.7 -0.5 -1.2 -1.8 -1.1 -1.7 -1.5 -1.5 -1.6 -1.8 -1.5 -2.2 -1.3 -0.6 -0.9
Alcohol drinker status: Never 1.0 1.2 3.4 1.1 0.6 1.6 0.8 1.5 1.0 -0.6 -0.4 0.8 1.2 0.8 1.7 0.2 1.2 0.7 0.7 0.7 0.8 1.0 1.1 0.9 0.4 1.8 1.3 1.8 1.2
Ever smoked 0.3 0.6 2.2 -0.6 -0.8 -0.6 -0.9 -1.5 -0.8 0.9 0.8 -0.7 -0.7 -0.4 -1.0 -1.0 0.6 -1.0 -0.4 -0.9 -0.8 -0.9 -0.7 -1.1 -0.4 -0.1 -0.2 -0.2 -0.9
Basal metabolic rate 1.5 8.4 22.4 -3.7 -2.2 -2.7 -2.9 -2.6 -3.0 2.3 2.5 -2.3 -1.1 -1.6 -3.3 -1.9 -4.7 -1.7 -3.4 -3.0 -2.6 -2.9 -3.0 -2.4 -2.3 -4.0 -3.6 -3.8 -3.0
Leg fat percentage (left) 1.9 6.9 21.3 -3.7 -0.5 -3.3 -2.8 -1.1 -3.8 2.6 1.6 -0.6 -1.9 1.1 -2.5 -2.2 -4.2 -1.4 -4.5 -2.5 -1.8 -2.3 -2.0 -2.6 -1.2 -4.6 -2.4 -2.1 -2.5
Arm fat-free mass (left) 0.9 4.4 15.7 -2.8 -1.4 -1.8 -2.0 -2.2 -2.3 1.5 1.6 -1.4 -0.7 -0.8 -2.4 -1.2 -4.0 -0.9 -2.6 -2.1 -1.7 -2.0 -2.1 -1.5 -1.4 -3.5 -2.5 -2.7 -2.0
Number of operations (self-reported) 0.3 0.4 1.3 -0.5 -0.7 -0.7 -0.7 -0.1 -0.9 1.1 0.6 -0.6 -0.2 -0.5 -0.4 -0.2 0.2 -0.7 0.3 -0.6 -0.8 -0.8 -0.6 -1.0 -0.3 -1.1 0.2 0.2 -0.3
Average weekly beer plus cider intake 0.2 0.2 1.4 -0.2 -0.8 -0.2 -0.4 0.3 -0.3 0.2 0.1 -0.8 0.0 -1.2 -0.1 0.0 -0.0 -0.1 0.7 -0.5 -0.7 -0.5 -0.5 -0.7 -0.7 -0.6 -0.2 0.2 -0.3
Irritability 3.4 5.7 8.8 -2.6 -2.6 -2.2 -2.6 -1.6 -2.3 2.4 2.4 -2.8 -0.6 -2.6 -2.7 -2.1 -1.2 -2.3 -1.4 -2.6 -2.8 -2.9 -2.8 -2.7 -2.8 -1.8 -2.2 -2.5 -3.0
Risk taking 0.9 1.3 3.9 1.2 1.1 2.0 0.9 0.4 0.8 -0.6 -0.7 1.2 1.4 1.2 0.9 1.2 1.6 0.8 1.3 1.0 1.2 1.0 1.3 1.0 1.2 1.4 1.1 1.3 0.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.7 -0.3 -0.3 -0.4 -0.5 -0.7 -0.6 0.6 0.6 -0.2 -0.2 0.0 -0.6 -1.3 0.5 -0.4 0.3 -0.5 -0.5 -0.5 -0.3 -0.6 -0.4 -0.1 0.4 0.3 -0.2
Fractured/broken bones in last 5 years 0.3 0.3 1.3 -0.7 -0.0 -0.5 -0.7 -0.5 -1.0 1.1 0.4 0.2 -1.2 1.0 -0.4 -0.4 -0.3 -0.7 -0.8 -0.4 -0.2 -0.5 0.1 -0.5 0.1 -0.4 0.2 0.1 -0.1
Age started oral contraceptive pill 1.2 1.5 3.3 1.6 1.3 0.4 1.6 -0.5 1.0 -1.1 -1.4 1.2 -1.4 0.7 1.2 -0.7 1.5 0.5 1.2 1.8 1.3 1.3 1.1 0.9 1.5 0.6 1.8 1.6 0.9
Diastolic blood pressure, automated reading 2.4 7.3 17.6 -2.5 -3.0 -3.6 -1.9 -1.4 -1.9 1.8 1.6 -3.2 -1.8 -3.7 -2.2 -2.1 -3.5 -2.5 -1.7 -2.1 -2.9 -2.5 -3.5 -2.7 -2.6 -4.2 -2.8 -2.9 -3.0
Ever depressed for a whole week 1.6 2.0 3.2 1.4 1.6 1.7 1.3 0.9 1.4 -1.3 -1.2 1.7 1.3 1.8 1.1 1.5 1.1 1.8 1.0 1.4 1.6 1.5 1.6 1.3 1.7 1.4 1.2 1.3 1.1
Unable to work because of sickness or disability 2.7 3.5 9.0 1.7 1.7 1.9 1.2 1.3 1.1 -0.5 -0.8 2.4 0.2 3.0 2.1 0.1 2.4 0.5 0.9 1.2 2.0 1.9 2.6 1.3 2.1 2.3 2.5 2.9 2.8
Commuting to job workplace: Cycle 0.5 0.6 7.4 -0.1 -0.0 0.2 -0.4 -2.7 -0.3 0.6 0.8 0.4 -1.2 1.0 -0.9 -1.1 0.9 -0.1 -0.4 -0.4 0.0 -0.4 0.1 -0.6 -0.1 1.1 0.1 0.5 -0.4
Myopia 0.4 0.6 2.3 0.4 1.2 -0.6 0.7 -0.9 0.4 -0.2 -1.0 1.3 -0.6 1.5 0.2 -0.7 -0.8 0.0 0.0 0.7 1.1 0.8 0.7 0.2 1.2 -1.5 0.3 0.3 0.4
Vascular/heart problems diagnosed by doctor 1.0 2.8 6.9 1.9 2.0 1.2 1.4 0.3 1.5 -1.0 -1.5 2.0 -0.5 2.1 1.6 1.9 2.6 0.7 1.8 1.5 1.9 1.6 2.3 1.4 1.4 2.0 1.6 2.1 1.6
Cholesterol lowering medication 0.5 0.8 2.2 0.8 0.5 0.8 1.0 1.0 0.9 -1.3 -1.0 0.6 0.8 -0.0 0.8 1.2 -0.2 1.5 1.1 1.0 0.8 0.7 0.7 1.2 0.9 -0.4 0.8 0.3 0.7
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 5.1 -1.9 -1.2 -1.7 -1.6 -1.3 -1.6 1.7 1.6 -1.2 -0.2 -0.6 -1.4 -2.3 -1.5 -1.1 -2.1 -1.6 -1.4 -1.6 -1.5 -1.4 -1.2 -0.6 -1.8 -1.5 -1.6
Pain experienced in last month 0.2 0.3 1.4 0.2 -0.1 -0.1 0.3 -0.6 0.0 0.0 -0.1 -0.6 -1.0 -1.2 -0.1 -0.2 -0.1 -0.6 -0.6 0.2 -0.3 -0.2 -0.5 -0.3 -0.1 -0.5 -1.1 -0.8 -1.0
Supplements: Calcium 0.2 0.3 1.3 0.3 0.9 1.1 0.5 0.4 0.0 -0.2 -0.5 0.7 -0.3 0.7 0.3 0.4 -0.1 0.2 0.0 0.6 0.6 0.4 0.6 0.6 0.5 0.1 -0.1 -0.1 -0.6
Basal cell carcinoma (self-reported) 0.3 0.4 2.2 -0.2 0.8 0.0 -0.2 -0.8 -0.4 0.3 0.1 0.6 -1.5 1.2 -0.1 0.2 0.2 -0.6 -1.5 -0.1 0.3 -0.0 0.3 0.2 0.0 0.8 -0.5 -0.2 -0.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.2 -1.1 -1.5 -0.4 -1.3 0.3 -1.2 0.9 1.5 -1.3 0.0 -0.9 -1.0 -1.0 -0.3 -0.7 -0.2 -1.1 -1.3 -1.2 -1.0 -0.9 -1.2 -0.1 -0.0 -0.5 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 8.6 0.9 0.9 2.2 0.4 1.4 0.8 -0.5 0.1 1.5 0.8 2.1 1.0 -0.2 1.9 1.0 1.4 0.7 1.1 1.0 1.8 1.2 1.4 2.9 2.7 1.9 1.9
Heart disease (siblings) 0.5 0.6 3.3 0.5 0.6 1.1 0.4 0.5 0.5 -0.5 -0.2 0.5 1.3 0.7 0.7 1.8 0.7 0.8 0.5 0.2 0.5 0.6 0.7 0.8 0.7 1.3 -0.4 -0.1 0.4
Alcohol drinker status: Previous 0.3 0.4 2.8 -0.7 0.7 0.0 -0.7 0.5 -0.8 0.8 0.3 0.8 1.2 1.7 -0.6 -0.4 -0.0 0.2 -0.6 -0.3 0.2 -0.3 0.4 -0.6 0.4 0.2 0.2 0.4 -0.2
Pack years of smoking 1.5 2.2 4.0 -1.9 -1.6 -1.7 -1.9 -0.2 -1.9 1.6 1.5 -1.4 -0.4 -1.1 -1.7 -0.9 -1.1 -1.3 -0.4 -1.7 -1.7 -1.8 -1.6 -1.8 -1.3 -2.0 -1.1 -1.5 -1.2
Impedance of whole body 13.6 69.1 144.0 -9.4 -6.0 -6.8 -9.3 -8.3 -12.0 10.5 8.2 -5.8 -11.8 -1.8 -8.3 -8.2 -4.8 -10.2 -10.1 -8.8 -7.7 -8.7 -6.6 -9.2 -7.2 -7.6 -6.7 -5.9 -9.0
Leg fat mass (left) 2.5 9.6 26.8 -4.3 -1.3 -3.5 -3.2 -1.9 -4.0 2.9 2.1 -1.5 -1.9 0.1 -3.1 -2.4 -5.2 -1.8 -5.0 -3.0 -2.4 -2.8 -2.8 -2.9 -1.8 -5.2 -3.3 -3.1 -3.2
Arm predicted mass (left) 0.9 4.4 15.9 -2.7 -1.3 -1.7 -2.0 -2.2 -2.2 1.3 1.5 -1.3 -0.6 -0.7 -2.5 -1.2 -4.0 -0.9 -2.9 -2.0 -1.6 -2.0 -2.0 -1.4 -1.3 -3.5 -2.6 -2.7 -2.1