Hub : Genes

NMB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1220 0.0490 1.2e-03 0.049 NA 0.019 NA 0.066 1.5e-03 NA 3.4e-02 NA 2.7e-04
2 GTEx Cells Transformed fibroblasts 0.1290 0.0360 3.3e-09 0.151 NA 0.133 NA 0.147 1.9e-11 NA 3.7e-10 NA 3.6e-11
3 GTEx Colon Sigmoid 0.1470 0.0630 4.9e-03 -0.008 NA 0.005 NA -0.007 9.3e-01 NA 2.1e-01 NA 7.3e-01
4 GTEx Esophagus Gastroesophageal Junction 0.1180 0.0530 7.9e-03 -0.006 NA 0.014 NA -0.007 6.1e-01 NA 9.7e-02 NA 6.7e-01
5 GTEx Esophagus Mucosa 0.0660 0.0290 4.4e-03 0.020 NA 0.008 NA 0.015 1.7e-02 NA 8.6e-02 NA 3.1e-02
6 GTEx Esophagus Muscularis 0.1310 0.0440 4.9e-06 0.118 NA 0.053 NA 0.076 1.2e-07 NA 3.8e-04 NA 2.2e-05
7 GTEx Muscle Skeletal 0.0678 0.0304 2.0e-03 0.001 NA 0.005 NA 0.003 2.2e-01 NA 9.9e-02 NA 1.5e-01
8 GTEx Pancreas 0.1740 0.0620 3.2e-05 0.183 NA 0.105 NA 0.136 3.4e-08 NA 3.4e-05 NA 2.4e-06
9 GTEx Spleen 0.1360 0.0580 4.8e-03 0.166 NA 0.092 NA 0.150 5.0e-05 NA 2.4e-03 NA 1.1e-04
10 GTEx Testis 0.4750 0.0630 0.0e+00 0.568 NA 0.574 NA 0.558 4.2e-30 NA 1.4e-30 NA 2.4e-29
11 METSIM Adipose 0.0830 0.0224 4.2e-13 0.103 0.094 0.096 0.101 0.101 3.7e-15 6.1e-14 3.5e-14 7.4e-15 6.8e-15
12 YFS Blood 0.0511 0.0130 0.0e+00 0.087 0.066 0.082 0.083 0.085 4.9e-27 1.3e-20 1.8e-25 1.1e-25 1.9e-26
13 TCGA Liver Hepatocellular Carcinoma 0.0590 0.0330 6.1e-03 0.037 0.017 0.024 NA 0.014 7.1e-03 4.9e-02 2.7e-02 NA 6.8e-02
14 TCGA Lung Squamous Cell Carcinoma 0.0709 0.0385 6.7e-04 0.003 0.014 0.006 NA 0.009 1.5e-01 8.2e-03 6.4e-02 NA 3.0e-02
15 TCGA Prostate Adenocarcinoma 0.1708 0.0575 0.0e+00 0.295 0.279 0.294 NA 0.292 3.4e-31 2.6e-29 5.3e-31 NA 9.1e-31
16 TCGA Thyroid Carcinoma 0.1060 0.0450 1.3e-09 0.106 0.090 0.085 NA 0.095 1.8e-10 4.6e-09 1.2e-08 NA 1.8e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 9.4 14.9 21.8 2.7 4.7 0.0 0.0 4.2 4.3 4.2 4.2 4.7 -4.3 4.7 4.5 4.2 0.6 4.1 -4.5
Bipolar Disorder or Schizophrenia 15.0 36.6 49.8 4.9 6.9 0.0 0.0 6.9 6.7 6.2 6.9 7.0 -6.7 7.1 7.0 6.6 1.7 6.9 -7.0
Depressed Affect (Nagel 2018) 1.5 3.1 7.9 -1.6 -2.1 0.0 0.0 -1.7 -1.7 -0.9 -1.6 -1.9 1.9 -1.9 -1.8 -2.2 -2.8 -2.1 1.7
Depression (Nagel 2018) 0.1 0.1 1.1 -0.3 -0.4 0.0 0.0 0.0 -0.0 -1.0 0.1 -0.0 0.4 0.2 -0.2 0.0 0.7 -0.4 0.2
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 -0.0 -0.4 0.0 0.0 -0.9 -0.8 -0.4 -0.9 -0.9 0.6 -0.4 -0.7 -0.5 0.7 -0.8 0.9
Neuroticism (Nagel 2018) 1.6 3.7 6.2 -1.8 -2.2 0.0 0.0 -2.0 -2.0 -0.5 -2.0 -2.1 2.3 -2.0 -2.0 -2.3 -2.5 -2.4 2.0
Schizophrenia (2018) 10.5 21.9 31.2 4.1 5.1 0.0 0.0 5.3 5.1 4.6 5.4 5.3 -5.2 5.3 5.4 5.1 1.6 5.6 -5.4
Schizophrenia vs Biploar Disorder 0.2 0.2 1.0 -0.6 0.0 0.0 0.0 0.5 0.3 -1.0 0.5 0.0 -0.3 0.0 0.4 0.5 0.7 0.7 -0.5
Worry (Nagel 2018) 0.4 0.7 1.3 -0.5 -1.0 0.0 0.0 -0.9 -1.0 0.5 -0.8 -1.0 1.1 -1.0 -1.0 -0.9 -0.9 -1.2 0.9
Alzheimer’s Disease (in mother) 0.4 0.5 2.0 1.4 0.7 0.0 0.0 0.6 0.7 1.1 0.7 0.5 -0.7 0.3 0.4 0.8 0.1 0.6 -0.7
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.4 0.5 0.0 0.0 0.7 0.8 0.6 0.7 0.7 -0.7 0.5 1.0 0.5 0.5 0.9 -0.8
Alzheimer’s Disease (including proxy) 1.3 1.8 2.9 1.7 1.5 0.0 0.0 1.6 1.5 1.6 1.6 1.4 -1.3 1.2 1.5 1.5 0.3 1.4 -1.6
Crohns Disease (2017) 0.8 1.8 6.8 0.4 1.2 0.0 0.0 1.2 1.4 2.6 1.2 1.3 -1.7 1.5 1.4 0.8 -1.6 1.5 -1.3
Irritable Bowel Disease (IBD) 0.5 1.3 5.2 0.9 1.1 0.0 0.0 0.8 1.1 2.2 0.8 1.0 -1.3 1.2 0.8 0.5 -2.3 0.8 -0.9
Ulcerative Colitis (UC) 0.2 0.3 3.8 0.6 0.1 0.0 0.0 -0.2 0.1 0.7 -0.2 0.0 0.0 0.2 -0.3 -0.3 -1.9 -0.5 0.1
Major Depression (MDD) 2.0 2.4 4.3 1.4 2.1 0.0 0.0 1.7 1.7 0.9 1.8 2.1 -1.9 1.9 1.8 1.5 0.4 1.7 -1.6
Reaction Time 0.1 0.1 0.5 0.0 0.7 0.0 0.0 0.2 0.1 -0.4 0.2 0.5 -0.3 0.6 -0.1 0.5 -0.2 0.1 -0.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.7 -0.9 -1.2 0.0 0.0 -1.4 -1.4 -0.7 -1.4 -1.4 1.5 -1.1 -1.3 -1.2 -0.1 -1.6 1.3
Breast Cancer 0.0 0.1 0.7 -0.5 -0.1 0.0 0.0 -0.4 -0.2 -0.8 -0.3 -0.3 0.3 -0.3 -0.2 -0.3 0.0 -0.3 0.4
Ovarian Cancer 0.0 0.0 0.3 -0.3 0.1 0.0 0.0 -0.1 -0.1 0.3 -0.1 -0.0 -0.5 -0.2 -0.0 0.1 0.4 0.0 0.1
Prostate Cancer 0.2 0.3 0.7 -0.4 -0.6 0.0 0.0 -0.5 -0.6 -0.0 -0.5 -0.6 0.5 -0.5 -0.8 -0.4 -0.8 -0.7 0.4
Age at First Birth 0.1 0.1 1.0 0.6 -0.0 0.0 0.0 -0.1 -0.0 0.6 -0.0 -0.1 0.0 -0.0 0.2 -0.1 -1.0 0.2 -0.0
Bipolar Disorder (2011) 10.3 10.0 14.7 2.1 3.6 0.0 0.0 3.5 3.7 2.4 3.5 3.6 -3.5 3.7 3.6 3.8 2.5 3.6 -3.5
Body Mass Index (BMI) (2010) 0.1 0.1 0.8 -0.4 0.1 0.0 0.0 0.0 -0.1 0.9 0.1 0.0 0.1 0.1 -0.0 0.0 -0.4 -0.1 -0.2
Coronary Artery Disease (CAD) 0.2 0.2 2.6 0.1 0.0 0.0 0.0 0.4 0.1 0.3 0.4 0.2 -0.1 0.0 0.1 -0.0 -1.6 0.1 -0.4
Crohns Disease (2012) 0.3 0.4 1.9 -0.6 0.5 0.0 0.0 0.5 0.7 1.4 0.4 0.6 -0.9 0.8 0.6 0.5 -0.3 0.6 -0.5
Mean Putamen Volume 2.0 2.3 3.6 1.1 1.8 0.0 0.0 1.7 1.8 1.8 1.8 1.8 -1.6 1.9 1.8 1.3 0.1 1.6 -1.7
Fasting Glucose 0.3 0.4 1.1 -0.5 -0.8 0.0 0.0 -0.6 -0.5 -0.7 -0.6 -0.7 0.5 -0.6 -0.6 -0.5 1.0 -0.4 0.8
HbA1C 0.9 1.0 1.7 -1.0 -0.9 0.0 0.0 -1.2 -1.3 -0.5 -1.2 -1.0 1.3 -1.2 -1.0 -1.1 0.1 -1.2 1.3
HDL Cholesterol 0.4 0.6 1.1 0.5 0.6 0.0 0.0 1.0 1.0 1.1 1.0 0.9 -1.0 0.8 0.7 0.6 -0.5 0.9 -0.8
LDL Cholesterol 1.1 1.7 5.4 2.3 1.3 0.0 0.0 1.2 1.2 1.8 1.3 1.5 -1.5 1.4 1.3 1.3 -0.2 1.0 -1.4
Lupus 0.5 0.7 1.4 0.2 0.7 0.0 0.0 1.2 1.0 0.4 1.1 1.0 -0.6 1.1 1.1 0.5 -1.2 0.8 -1.1
Neuroticism (2016) 0.2 0.3 1.3 0.6 0.9 0.0 0.0 -0.0 0.5 -0.6 0.4 0.6 -0.3 0.7 0.2 0.6 1.2 0.0 -0.1
Primary Biliary Cirrhosis 0.1 0.2 0.5 -0.2 -0.0 0.0 0.0 -0.6 -0.6 -0.1 -0.6 -0.3 0.3 -0.2 -0.7 -0.1 0.0 -0.7 0.6
Rheumatoid Arthritis 1.8 2.4 4.7 -2.0 -1.6 0.0 0.0 -1.5 -1.6 -1.3 -1.5 -1.5 1.5 -1.7 -1.6 -1.8 -1.9 -2.2 1.4
Schizophrenia (2014) 9.5 21.0 31.8 3.5 5.0 0.0 0.0 5.3 5.1 4.0 5.3 5.1 -5.0 5.2 5.5 5.1 2.1 5.6 -5.4
Triglycerides 0.2 0.3 2.2 0.7 0.6 0.0 0.0 0.4 0.4 -0.1 0.4 0.4 -0.2 0.5 0.6 0.8 1.5 0.3 -0.5
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.2 -1.5 -0.5 0.0 0.0 -0.8 -0.8 -1.3 -0.7 -0.6 0.6 -0.4 -0.2 -0.7 -0.6 -0.8 0.5
Ulcerative Colitis 0.3 0.4 2.3 1.5 0.5 0.0 0.0 -0.0 0.3 1.5 -0.0 0.3 -0.2 0.5 -0.2 0.4 -0.9 -0.0 -0.2
Blood Eosinophil Count 2.1 16.4 25.8 2.4 4.4 0.0 0.0 4.9 5.0 2.7 5.0 5.0 -4.8 4.6 5.0 3.7 -2.1 4.3 -5.1
Blood Platelet Count 1.0 11.9 19.8 3.2 3.6 0.0 0.0 4.0 4.1 2.9 3.9 4.0 -4.4 3.8 4.1 3.1 -1.4 4.0 -4.1
Blood Red Count 0.6 5.5 8.7 -1.2 -2.3 0.0 0.0 -2.8 -2.7 -2.8 -2.8 -2.6 2.8 -2.7 -2.7 -2.3 -0.3 -2.8 3.0
Blood White Count 0.6 4.3 7.3 0.4 2.1 0.0 0.0 2.6 2.7 -1.0 2.6 2.5 -2.6 2.4 2.7 1.8 0.8 2.5 -2.4
Heel T-Score 1.8 14.6 23.8 2.6 4.5 0.0 0.0 4.4 4.3 3.4 4.5 4.5 -4.9 4.1 4.4 4.3 0.5 4.0 -4.7
BMI 0.6 3.3 5.8 -2.4 -2.0 0.0 0.0 -1.8 -1.8 -2.2 -1.8 -1.9 2.1 -2.1 -1.9 -2.1 -0.2 -2.1 1.9
Height 5.2 101.0 146.4 -8.4 -10.7 0.0 0.0 -11.4 -11.2 -12.1 -11.5 -11.0 11.1 -10.7 -11.1 -11.5 -2.9 -11.6 11.8
Waist Hip Ratio (WHR) 1.0 4.3 15.8 -0.2 -1.7 0.0 0.0 -2.3 -2.2 -4.0 -2.4 -2.0 2.2 -1.9 -2.2 -1.8 1.3 -2.0 2.8
Systolic Blood Pressure 0.2 1.1 4.8 -0.9 -1.2 0.0 0.0 -0.7 -0.9 -2.2 -0.8 -1.1 1.4 -0.5 -0.8 -0.6 1.6 -0.9 0.9
Smoking Status 0.0 0.1 0.5 0.2 0.3 0.0 0.0 0.1 0.2 -0.6 0.1 0.2 -0.0 0.3 0.3 0.3 -0.7 0.0 -0.4
Allergy or Eczema 2.1 5.6 8.4 2.1 2.8 0.0 0.0 2.6 2.6 2.6 2.6 2.7 -2.9 2.7 2.6 2.6 0.6 2.6 -2.7
Cardiovascular Disease 1.3 4.3 16.0 -2.7 -2.1 0.0 0.0 -1.8 -1.9 -4.0 -1.9 -2.0 2.4 -1.8 -2.0 -1.6 1.5 -2.3 1.9
Hypothyroidism (self reported) 1.2 2.8 4.7 -0.8 -1.6 0.0 0.0 -2.1 -2.0 -1.6 -2.0 -2.0 2.0 -2.2 -1.6 -1.6 0.4 -1.9 2.1
Respiratory disease 0.6 1.4 2.9 1.3 1.6 0.0 0.0 1.0 1.1 1.7 1.0 1.3 -1.2 1.4 1.1 1.3 -0.2 1.4 -1.1
Type 2 Diabetes (T2D) (2018) 1.4 2.6 4.7 -0.9 -1.6 0.0 0.0 -1.8 -1.9 -1.0 -1.9 -1.7 1.6 -1.7 -2.2 -1.8 -1.6 -2.1 1.9
Lung FEV1/FVC ratio 2.7 13.9 38.8 -3.7 -4.0 0.0 0.0 -3.7 -3.6 -6.2 -3.5 -3.9 3.7 -4.1 -3.7 -4.1 1.3 -4.4 4.2
Lung FVC 0.3 1.5 7.8 -2.3 -1.4 0.0 0.0 -0.6 -0.7 1.1 -0.7 -0.7 0.9 -0.7 -0.6 -1.8 -2.8 -0.4 0.7
Neuroticism 1.1 2.6 3.8 -1.2 -1.8 0.0 0.0 -1.8 -1.8 -0.5 -1.7 -1.8 2.0 -1.8 -1.7 -1.9 -1.9 -1.9 1.8
Chronotype (morning person) 2.5 5.7 9.3 -2.9 -2.6 0.0 0.0 -2.6 -2.5 -1.6 -2.5 -2.7 2.7 -3.0 -2.7 -2.5 -1.5 -3.0 2.4
Hair Pigment 0.1 2.2 5.7 -0.1 -1.6 0.0 0.0 -1.8 -1.8 -0.3 -1.8 -1.6 1.0 -1.4 -1.6 -1.9 -2.4 -1.6 1.6
Tanning 0.0 0.1 0.9 -0.6 0.2 0.0 0.0 0.0 0.1 0.4 0.1 0.2 -0.2 0.6 0.1 0.2 -1.0 -0.2 -0.3
Hand grip strength (left) 0.6 1.7 3.4 0.0 1.3 0.0 0.0 1.6 1.6 0.7 1.6 1.7 -1.4 1.6 1.6 0.8 -0.9 1.8 -1.4
Number of treatments/medications taken 0.1 0.2 2.4 -0.0 -0.2 0.0 0.0 -0.0 0.0 -1.6 -0.0 -0.1 -0.2 -0.1 -0.2 0.1 1.1 -0.2 0.2
Average weekly spirits intake 0.0 0.1 0.3 -0.4 -0.2 0.0 0.0 0.1 0.1 -0.3 0.1 -0.1 0.5 -0.3 0.2 -0.0 -0.3 0.1 -0.3
Sensitivity / hurt feelings 0.2 0.3 2.6 -0.3 0.1 0.0 0.0 0.5 0.4 0.5 0.6 0.4 -0.2 0.3 0.3 -0.1 -1.6 0.0 -0.5
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.5 -0.4 -1.0 0.0 0.0 -1.2 -1.1 -1.7 -1.1 -1.1 1.9 -1.1 -1.5 -0.9 0.5 -1.7 1.4
Hearing difficulty/problems: Yes 2.6 4.0 8.2 1.1 2.2 0.0 0.0 2.4 2.6 -0.2 2.4 2.5 -2.3 2.5 2.9 1.5 -0.4 2.3 -2.5
Relative age of first facial hair 1.8 3.7 5.9 -1.0 -2.1 0.0 0.0 -2.3 -2.4 0.3 -2.3 -2.3 2.2 -2.1 -2.3 -2.2 -1.1 -2.1 2.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.5 -0.7 -0.5 0.0 0.0 -0.6 -0.5 -1.6 -0.5 -0.4 0.3 -0.4 -0.4 -0.9 -0.6 -0.5 0.6
Ever used hormone-replacement therapy (HRT) 4.3 5.4 8.9 2.3 2.4 0.0 0.0 2.6 2.6 3.0 2.6 2.5 -2.6 2.5 2.4 2.6 0.6 2.5 -2.8
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.6 0.0 0.0 0.0 0.2 0.2 0.1 0.3 0.1 -0.2 0.2 0.3 0.1 0.5 -0.1 -0.2
Systolic blood pressure, automated reading 0.5 1.6 5.6 0.7 1.0 0.0 0.0 1.5 1.4 0.0 1.4 1.1 -1.1 1.5 1.3 1.6 2.4 1.3 -1.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.4 -0.1 -0.5 0.0 0.0 -0.4 -0.5 -0.6 -0.4 -0.4 0.6 -0.2 -0.4 -0.4 -0.1 -0.3 0.4
Angina 0.1 0.2 1.1 -0.2 -0.4 0.0 0.0 0.1 0.1 -1.0 0.2 -0.1 -0.1 0.0 -0.0 0.1 1.0 0.0 0.2
Medication for hormone replacement therapy 0.2 0.2 0.6 -0.0 0.7 0.0 0.0 0.4 0.5 0.0 0.4 0.7 -0.8 0.7 0.2 0.2 -0.4 -0.1 -0.4
Vitamin and mineral supplements 2.4 3.2 5.9 -2.4 -1.9 0.0 0.0 -1.9 -2.0 -1.7 -1.9 -1.9 1.7 -1.9 -2.0 -2.1 -0.7 -2.2 2.0
Supplements: Zinc 0.2 0.2 1.5 0.8 0.2 0.0 0.0 0.2 0.3 1.2 0.3 0.2 -0.0 0.3 0.1 0.4 0.2 0.1 -0.3
Medication: Co-codamol 2.9 3.3 5.0 -2.2 -1.9 0.0 0.0 -2.0 -2.0 -1.8 -2.0 -2.0 2.1 -2.0 -2.2 -1.8 -0.5 -2.1 1.9
Medication: Metformin 0.5 0.7 1.2 -0.7 -1.0 0.0 0.0 -0.8 -1.0 -0.6 -0.9 -0.8 0.8 -0.9 -1.0 -1.0 -1.1 -0.9 0.9
Diabetes (father) 2.9 3.6 6.2 -1.3 -2.3 0.0 0.0 -2.2 -2.1 0.0 -2.2 -2.1 2.0 -2.2 -2.0 -2.5 -1.9 -2.2 2.1
Diabetes (mother) 0.3 0.3 1.0 -0.1 -1.0 0.0 0.0 -0.6 -0.5 -0.3 -0.5 -0.7 0.2 -0.5 -0.5 -1.0 -0.8 -0.6 0.7
Severe depression (siblings) 1.3 1.4 2.8 0.4 1.5 0.0 0.0 1.4 1.3 0.3 1.5 1.5 -0.9 1.4 1.7 1.3 0.4 1.4 -1.6
Pack years adult smoking proportion 0.1 0.2 1.3 1.1 -0.2 0.0 0.0 -0.4 -0.3 -0.1 -0.3 -0.4 0.5 -0.5 -0.3 0.0 0.9 -0.3 0.5
Impedance of leg (right) 4.4 21.4 46.5 -5.3 -5.0 0.0 0.0 -4.9 -4.9 -6.8 -4.9 -4.8 4.8 -4.7 -4.5 -5.3 -0.7 -5.2 5.2
Leg fat-free mass (left) 0.6 3.3 5.3 -0.9 -1.8 0.0 0.0 -2.1 -2.1 -1.6 -2.2 -2.0 2.0 -1.9 -2.3 -1.9 0.1 -2.3 2.3
Trunk fat percentage 3.7 14.9 47.3 -4.1 -3.9 0.0 0.0 -4.0 -3.8 -6.9 -4.0 -3.9 4.0 -3.8 -3.6 -4.3 0.1 -4.3 4.2
Hand grip strength (right) 0.1 0.3 2.1 0.5 0.4 0.0 0.0 0.4 0.4 0.2 0.4 0.6 -0.4 0.5 0.4 -0.3 -1.4 0.6 -0.2
Townsend deprivation index at recruitment 0.3 0.4 0.7 -0.6 -0.6 0.0 0.0 -0.6 -0.7 -0.7 -0.5 -0.7 0.5 -0.8 -0.8 -0.5 0.5 -0.8 0.7
Current tobacco smoking 0.5 0.8 1.4 0.7 1.0 0.0 0.0 1.0 1.2 0.1 1.1 1.0 -1.0 1.0 1.2 0.9 -0.1 1.2 -1.0
Average weekly fortified wine intake 0.4 0.5 1.9 -0.1 -0.7 0.0 0.0 -0.8 -0.8 1.4 -0.8 -0.8 1.0 -0.9 -0.7 -0.5 -0.6 -0.4 0.5
Maternal smoking around birth 0.3 0.4 1.9 0.9 0.6 0.0 0.0 0.7 0.6 1.4 0.8 0.6 -0.7 0.5 0.5 0.5 0.1 0.6 -0.5
Fed-up feelings 3.5 6.3 10.1 -2.3 -2.7 0.0 0.0 -2.7 -2.7 -3.2 -2.6 -2.8 3.0 -2.8 -2.7 -2.7 -0.4 -2.9 2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.1 -0.3 -0.6 0.0 0.0 -0.8 -0.8 -1.4 -0.7 -0.7 0.8 -0.6 -0.9 -0.5 1.0 -1.1 1.0
Relative age voice broke 0.1 0.2 1.9 -0.5 0.1 0.0 0.0 -0.1 -0.2 -0.3 -0.1 -0.1 0.1 0.0 -0.2 -0.0 1.4 -0.2 0.3
Taking other prescription medications 0.1 0.2 0.6 0.7 -0.0 0.0 0.0 0.5 0.5 -0.7 0.5 0.2 -0.7 0.3 0.3 0.1 -0.1 0.4 -0.3
Age when periods started (menarche) 2.7 6.4 9.1 2.6 2.8 0.0 0.0 2.8 2.9 2.8 2.7 2.9 -2.8 3.0 2.8 2.3 -1.1 2.6 -2.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.7 0.7 0.4 0.0 0.0 0.8 0.8 0.6 0.8 0.6 -0.5 0.7 0.8 0.7 0.5 0.4 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 2.7 1.1 1.2 0.0 0.0 1.4 1.4 1.3 1.4 1.2 -1.6 0.9 1.3 1.5 1.3 1.1 -1.5
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.3 0.5 -0.2 0.0 0.0 -0.2 -0.2 -0.1 -0.2 -0.2 0.1 -0.2 -0.3 -0.2 0.2 -0.0 0.3
Qualifications: CSEs or equivalent 0.0 0.0 0.2 0.4 0.2 0.0 0.0 -0.0 0.0 -0.4 0.1 0.1 0.0 -0.0 -0.2 -0.2 -0.1 0.0 0.1
Serious illness, injury or assault to yourself 0.4 0.5 2.8 -1.4 -0.3 0.0 0.0 -0.4 -0.4 -1.7 -0.4 -0.4 0.2 -0.5 -0.5 -0.6 1.2 -0.6 0.7
High blood pressure 0.6 1.7 11.0 -1.4 -0.9 0.0 0.0 -0.9 -0.9 -3.3 -0.9 -1.0 1.2 -0.7 -1.2 -0.6 1.9 -1.4 1.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.5 1.1 1.1 0.0 0.0 0.6 0.6 1.6 0.5 0.9 -0.9 0.9 0.4 0.8 -0.8 0.7 -0.7
Multivitamins +/- minerals 3.3 4.2 6.2 2.5 2.4 0.0 0.0 2.2 2.2 2.3 2.2 2.3 -2.1 2.3 2.3 2.3 0.5 2.4 -2.2
Stomach or abdominal pain in last month 0.1 0.1 0.5 0.7 0.3 0.0 0.0 0.2 0.2 0.2 0.2 0.3 0.1 0.2 0.1 0.4 0.7 0.2 -0.1
Supplements: Glucosamine 2.6 3.3 5.2 -0.3 -2.1 0.0 0.0 -2.3 -2.2 0.2 -2.3 -2.2 2.3 -2.2 -2.0 -2.3 -1.2 -1.7 2.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 -0.5 -1.3 0.0 0.0 -1.0 -1.0 -0.3 -0.9 -1.2 0.8 -1.0 -0.9 -1.0 0.0 -1.0 1.0
Medication: Atenolol 1.6 2.0 11.0 1.4 1.3 0.0 0.0 1.3 1.3 -0.1 1.3 1.2 -1.0 1.5 1.4 1.9 3.3 1.2 -1.2
Medication: Levothyroxine sodium 0.8 1.3 2.8 -0.7 -1.2 0.0 0.0 -1.4 -1.4 -0.7 -1.4 -1.4 1.3 -1.7 -1.1 -1.2 -0.2 -1.2 1.4
Sitting height 3.5 24.5 37.6 -4.1 -5.3 0.0 0.0 -5.7 -5.6 -4.9 -5.8 -5.5 5.9 -5.3 -5.5 -5.4 -1.2 -6.1 5.8
Chronic bronchitis/emphysema (father) 3.9 4.6 6.9 1.8 2.5 0.0 0.0 2.4 2.5 2.6 2.4 2.4 -2.1 2.3 2.4 2.5 0.6 2.3 -2.4
High blood pressure (mother) 0.2 0.2 1.9 -1.4 -0.3 0.0 0.0 -0.1 -0.1 -0.1 -0.0 -0.1 0.4 -0.1 -0.3 -0.5 -1.0 -0.6 0.1
Body mass index (BMI) 0.1 0.3 0.6 -0.3 0.4 0.0 0.0 0.6 0.7 -0.5 0.7 0.6 -0.4 0.4 0.7 0.3 0.8 0.4 -0.5
Impedance of leg (left) 4.5 22.1 51.1 -5.3 -4.9 0.0 0.0 -4.9 -5.0 -7.2 -4.9 -4.8 5.0 -4.8 -4.6 -5.4 -1.0 -5.3 5.2
Leg predicted mass (left) 0.6 3.1 5.2 -0.9 -1.8 0.0 0.0 -2.1 -2.0 -1.7 -2.2 -2.0 2.0 -1.9 -2.2 -1.9 0.1 -2.3 2.3
Trunk fat mass 3.6 15.7 43.8 -3.9 -4.0 0.0 0.0 -4.2 -4.0 -6.6 -4.2 -4.1 4.1 -3.9 -3.8 -4.4 -0.0 -4.5 4.4
Waist circumference 1.4 5.0 20.9 -2.3 -2.1 0.0 0.0 -2.2 -2.1 -4.6 -2.2 -2.1 2.2 -2.1 -2.0 -2.4 0.7 -2.4 2.5
Number of incorrect matches in round 1.9 3.1 4.9 1.2 2.0 0.0 0.0 2.1 2.0 1.4 2.2 2.1 -2.1 1.8 2.0 1.7 -0.9 2.1 -2.2
Past tobacco smoking 0.1 0.1 0.5 -0.3 -0.0 0.0 0.0 -0.4 -0.4 -0.0 -0.3 -0.2 0.0 -0.3 -0.7 -0.2 0.3 -0.4 0.6
Alcohol usually taken with meals 0.4 0.7 3.1 1.8 1.0 0.0 0.0 0.8 0.6 0.8 0.7 0.8 -0.6 0.9 0.6 1.1 0.4 0.6 -0.9
Nervous feelings 0.2 0.4 1.5 0.7 0.9 0.0 0.0 0.7 0.6 1.2 0.7 0.8 -0.4 0.7 0.3 0.8 -0.0 0.3 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 2.9 1.7 0.7 0.0 0.0 0.2 0.3 0.5 0.3 0.5 -0.3 0.6 -0.2 0.3 -0.3 -0.1 0.0
Hearing difficulty/problems with background noise 2.9 4.6 8.1 1.5 2.9 0.0 0.0 2.5 2.5 0.9 2.5 2.7 -2.2 2.7 2.7 2.3 0.8 2.3 -2.5
Hair/balding pattern: Pattern 2 0.5 0.7 2.7 -1.1 -0.7 0.0 0.0 -0.7 -0.8 1.3 -0.7 -0.6 0.7 -0.6 -0.7 -0.7 -1.7 -0.7 0.5
Had menopause 8.8 11.0 16.8 3.0 3.4 0.0 0.0 4.0 4.0 2.5 4.0 3.7 -3.9 3.5 4.1 3.2 0.8 4.0 -4.0
Had other major operations 0.2 0.2 1.2 0.1 -0.9 0.0 0.0 -0.3 -0.3 1.1 -0.3 -0.6 0.2 -0.4 -0.2 -0.6 -0.4 -0.2 0.5
Forced vital capacity (FVC) 3.0 11.5 19.5 -3.7 -3.9 0.0 0.0 -3.7 -3.8 -1.8 -3.9 -3.6 3.9 -3.5 -3.6 -4.4 -2.4 -3.6 4.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.1 1.2 0.9 0.0 0.0 1.1 1.1 1.8 1.1 0.9 -1.5 0.5 1.0 1.0 0.1 0.8 -1.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 0.1 0.7 0.0 0.0 0.7 0.7 -0.7 0.7 0.7 -0.7 0.6 0.7 0.7 0.4 0.6 -0.7
Qualifications: None of the above 0.2 0.4 3.0 -1.7 0.0 0.0 0.0 0.7 0.7 -0.2 0.8 0.4 -0.4 0.2 0.7 0.1 -0.4 0.7 -0.6
Financial difficulties in last 2 years 0.2 0.2 1.2 1.1 0.6 0.0 0.0 0.2 0.3 0.4 0.3 0.4 -0.4 0.6 0.2 0.6 0.8 0.2 -0.1
Mouth/teeth dental problems 0.1 0.2 1.1 -0.2 -0.1 0.0 0.0 -0.5 -0.5 -1.1 -0.5 -0.3 0.3 -0.3 -0.3 -0.3 -0.2 -0.2 0.5
Heart attack 0.3 0.4 0.8 0.0 -0.9 0.0 0.0 -0.8 -0.7 -0.8 -0.8 -0.9 0.5 -0.6 -0.7 -0.6 0.5 -0.8 0.9
Allergy 0.9 2.1 3.7 -1.7 -1.9 0.0 0.0 -1.4 -1.4 -1.7 -1.3 -1.7 1.6 -1.8 -1.3 -1.5 0.6 -1.7 1.5
Pain all over the body in last month 1.0 1.1 3.2 -1.6 -1.0 0.0 0.0 -1.1 -0.9 -0.1 -1.0 -0.9 0.6 -0.6 -1.0 -1.4 -1.8 -1.0 1.1
Diabetes (self-reported) 0.1 0.2 0.6 -0.0 -0.6 0.0 0.0 -0.5 -0.5 -0.1 -0.6 -0.4 0.1 -0.4 -0.8 -0.5 -0.6 -0.8 0.6
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.5 -0.8 -1.0 0.0 0.0 -1.5 -1.6 -0.5 -1.5 -1.2 1.5 -1.2 -1.5 -1.1 -0.2 -1.6 1.4
Medication: Ramipril 0.1 0.1 1.3 -1.2 0.2 0.0 0.0 0.1 0.1 -0.9 0.2 0.2 0.2 0.2 0.1 -0.0 0.2 -0.1 -0.1
Medication: Simvastatin 0.8 1.2 3.7 0.8 1.0 0.0 0.0 1.2 1.2 -1.3 1.2 1.1 -1.2 1.1 0.9 1.3 1.9 0.6 -1.0
Fluid intelligence score 1.1 2.4 8.3 -0.8 -1.4 0.0 0.0 -1.7 -1.7 -2.9 -1.7 -1.7 1.7 -1.4 -1.6 -1.5 -0.2 -2.0 1.6
Illnesses of siblings 0.1 0.1 1.5 1.2 0.4 0.0 0.0 -0.1 -0.1 -0.0 -0.1 0.1 -0.3 0.0 0.0 0.1 0.2 -0.2 0.1
Neuroticism score 0.7 1.5 2.7 -0.7 -1.2 0.0 0.0 -1.3 -1.3 -1.0 -1.2 -1.2 1.5 -1.2 -1.4 -1.4 -1.6 -1.6 1.4
Weight 2.1 10.3 20.6 -3.2 -3.4 0.0 0.0 -3.5 -3.3 -4.5 -3.5 -3.4 3.5 -3.3 -3.3 -3.7 0.0 -3.8 3.8
Impedance of arm (right) 2.8 12.8 30.5 -3.5 -3.9 0.0 0.0 -3.9 -3.9 -5.5 -3.9 -4.0 3.5 -3.7 -3.5 -4.0 -0.8 -3.8 4.0
Arm fat percentage (right) 0.4 1.7 9.7 -1.6 -1.2 0.0 0.0 -1.1 -1.0 -3.1 -1.1 -1.1 1.1 -1.1 -0.9 -1.4 0.6 -1.3 1.3
Trunk fat-free mass 0.7 3.9 6.3 -1.5 -2.1 0.0 0.0 -2.3 -2.2 -1.3 -2.4 -2.2 2.2 -2.2 -2.5 -2.2 -0.3 -2.5 2.5
Hip circumference 1.7 7.5 16.6 -3.6 -2.8 0.0 0.0 -2.8 -2.7 -4.1 -2.8 -2.7 2.8 -2.8 -2.6 -3.1 0.1 -3.2 3.0
Time employed in main current job 0.4 0.5 1.1 -0.9 0.5 0.0 0.0 0.8 0.9 0.0 0.8 0.7 -1.0 0.5 0.9 0.8 0.6 0.9 -0.7
Alcohol intake versus 10 years previously 0.4 0.7 1.2 -0.9 -0.9 0.0 0.0 -1.0 -0.9 -0.5 -1.0 -0.9 0.7 -0.9 -0.8 -1.0 -0.2 -0.9 1.1
Father’s age at death 0.6 0.8 6.2 2.5 0.8 0.0 0.0 0.7 0.7 0.6 0.6 0.8 -0.6 0.7 0.9 0.7 0.2 1.1 -0.7
Worrier / anxious feelings 0.6 1.2 2.8 -0.9 -1.3 0.0 0.0 -1.0 -1.1 -0.6 -0.9 -1.1 1.2 -1.0 -1.1 -1.4 -1.7 -1.7 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 2.4 -0.3 -0.5 0.0 0.0 -1.0 -1.0 -0.1 -0.9 -0.8 0.8 -0.7 -1.5 -0.5 1.0 -1.3 1.3
Falls in the last year 5.5 7.5 11.2 -2.6 -2.9 0.0 0.0 -3.2 -3.1 -1.3 -3.1 -3.0 3.1 -3.1 -3.3 -3.1 -1.8 -3.1 3.3
Hair/balding pattern: Pattern 3 2.5 3.7 9.4 3.1 1.8 0.0 0.0 2.0 2.1 1.3 2.0 1.9 -2.2 1.8 2.0 2.2 1.2 2.4 -2.0
Number of live births 3.6 5.0 7.0 2.1 2.4 0.0 0.0 2.6 2.6 2.4 2.6 2.5 -2.5 2.5 2.5 2.3 -0.0 2.6 -2.6
Forced expiratory volume in 1-second (FEV1) 5.5 18.5 30.1 -4.6 -5.0 0.0 0.0 -4.7 -4.8 -3.0 -4.8 -4.7 5.0 -4.7 -4.7 -5.5 -2.0 -4.8 5.1
Pulse rate 0.9 1.5 4.9 0.5 1.7 0.0 0.0 1.0 1.3 -1.1 1.1 1.4 -1.1 1.4 0.8 1.8 2.2 0.8 -0.9
Happiness 0.1 0.1 0.8 0.6 -0.2 0.0 0.0 -0.3 -0.2 -0.3 -0.3 -0.2 0.4 -0.2 -0.6 -0.1 -0.3 -0.9 0.3
Noisy workplace 2.4 3.0 5.5 1.0 1.7 0.0 0.0 2.1 2.2 -0.0 2.1 1.9 -2.0 1.9 2.3 1.9 0.9 2.2 -2.2
Qualifications: A levels/AS levels or equivalent 1.4 3.1 5.9 -0.9 -1.6 0.0 0.0 -2.3 -2.2 -1.1 -2.3 -2.0 2.3 -1.8 -2.4 -1.5 0.4 -2.1 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.3 -1.2 -0.5 0.0 0.0 -0.2 -0.2 -1.0 -0.1 -0.4 0.3 -0.3 0.3 -0.6 -0.3 -0.0 0.1
Mouth/teeth dental problems: Dentures 1.6 2.7 4.3 1.8 1.7 0.0 0.0 1.8 2.0 1.8 1.8 1.7 -1.8 1.7 1.8 1.7 -0.2 2.0 -2.1
Asthma 0.5 1.1 2.1 1.1 1.2 0.0 0.0 1.0 1.0 1.0 1.1 1.1 -1.0 1.2 1.2 1.1 -0.1 1.5 -1.2
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.3 -1.6 -1.5 0.0 0.0 -1.6 -1.5 -0.1 -1.6 -1.4 1.7 -1.6 -1.2 -1.8 -1.2 -1.5 1.5
Medication: Cholesterol lowering 0.3 0.4 4.2 0.0 0.3 0.0 0.0 0.3 0.5 -2.1 0.4 0.4 -0.8 0.5 0.3 0.2 0.8 0.0 -0.2
Depression (self-reported) 0.3 0.3 1.3 1.1 1.0 0.0 0.0 0.6 0.5 0.1 0.7 0.8 -0.5 0.7 0.2 0.6 -0.3 0.3 -0.5
Medication: Lansoprazole 0.4 0.4 2.8 -0.0 -0.7 0.0 0.0 -0.5 -0.5 1.0 -0.5 -0.5 0.4 -0.5 -0.5 -0.7 -1.7 -0.6 0.4
Prospective memory result 0.9 1.1 2.0 0.3 1.0 0.0 0.0 1.2 1.2 1.1 1.3 1.1 -1.1 0.8 1.4 1.4 0.8 1.4 -1.4
Lung cancer (father) 0.2 0.3 1.4 0.4 -0.4 0.0 0.0 -0.2 -0.2 1.0 -0.2 -0.3 0.3 -0.2 -0.5 -0.3 -1.2 -0.7 0.1
Illnesses of mother 1.5 1.8 3.4 -0.2 -1.3 0.0 0.0 -1.8 -1.8 -0.3 -1.8 -1.6 1.5 -1.6 -1.7 -1.3 -0.2 -1.5 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 5.1 16.3 25.4 -4.3 -4.6 0.0 0.0 -4.5 -4.6 -2.3 -4.6 -4.4 4.5 -4.4 -4.5 -5.0 -1.6 -4.6 4.9
Pulse wave Arterial Stiffness index 1.5 1.8 3.2 0.1 -1.1 0.0 0.0 -1.6 -1.5 -1.7 -1.7 -1.4 1.8 -1.5 -1.6 -1.0 0.8 -1.5 1.7
Impedance of arm (left) 3.5 16.2 34.8 -3.7 -4.3 0.0 0.0 -4.5 -4.4 -5.9 -4.5 -4.4 4.0 -4.2 -4.0 -4.6 -1.2 -4.4 4.5
Arm fat mass (right) 0.8 3.2 11.2 -2.1 -1.8 0.0 0.0 -1.7 -1.6 -3.3 -1.7 -1.7 1.8 -1.8 -1.6 -2.0 0.4 -2.1 1.9
Trunk predicted mass 0.7 3.7 6.1 -1.4 -2.1 0.0 0.0 -2.3 -2.2 -1.2 -2.3 -2.2 2.2 -2.1 -2.4 -2.2 -0.3 -2.5 2.4
Standing height 6.2 61.7 88.2 -6.5 -8.4 0.0 0.0 -8.9 -8.9 -8.9 -9.1 -8.7 8.6 -8.4 -8.8 -8.9 -1.8 -9.2 9.4
Length of working week for main job 0.1 0.1 0.9 -0.2 -0.1 0.0 0.0 -0.2 -0.2 -0.7 -0.3 -0.2 -0.1 -0.5 -0.2 -0.4 -1.0 -0.1 0.2
Exposure to tobacco smoke at home 0.1 0.2 0.7 0.1 0.3 0.0 0.0 0.4 0.4 0.6 0.5 0.2 -0.3 0.1 0.1 0.7 0.8 0.2 -0.4
Breastfed as a baby 1.4 1.7 3.0 1.0 1.4 0.0 0.0 1.5 1.5 1.2 1.5 1.5 -1.4 1.5 1.6 1.4 -0.5 1.4 -1.7
Tense / ‘highly strung’ 1.5 2.5 3.8 1.7 1.6 0.0 0.0 1.8 1.8 1.9 1.9 1.7 -1.6 1.5 1.8 1.6 -0.6 1.9 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.6 6.2 2.5 2.2 0.0 0.0 2.2 2.1 1.0 2.2 2.1 -1.9 2.3 2.3 1.9 -0.4 2.2 -2.1
Hair/balding pattern: Pattern 4 0.2 0.5 4.8 -2.2 -0.4 0.0 0.0 -0.3 -0.2 -0.6 -0.2 -0.2 0.8 -0.2 -0.4 -0.8 -0.7 -0.8 0.4
Birth weight of first child 0.1 0.1 1.1 -0.4 -0.3 0.0 0.0 0.0 -0.1 -1.0 0.1 -0.0 -0.1 0.0 -0.1 -0.5 -0.4 -0.4 0.0
Peak expiratory flow (PEF) 3.3 7.7 12.6 -2.1 -3.3 0.0 0.0 -3.1 -3.2 -1.0 -3.1 -3.1 3.4 -3.2 -3.2 -3.5 -2.2 -2.9 3.1
Pulse wave reflection index 1.3 1.6 3.2 -0.6 -1.3 0.0 0.0 -1.4 -1.6 -0.5 -1.5 -1.5 1.8 -1.8 -1.4 -1.2 -0.1 -1.6 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.5 3.9 0.2 -0.2 0.0 0.0 -0.5 -0.6 -2.0 -0.5 -0.4 0.9 -0.5 -0.6 0.0 1.3 -0.6 0.5
Loud music exposure frequency 0.1 0.1 1.3 0.2 0.1 0.0 0.0 -0.1 -0.1 1.1 -0.2 0.1 0.1 0.0 -0.1 -0.0 -0.2 0.1 0.1
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 4.8 -0.6 -1.6 0.0 0.0 -2.1 -2.0 -1.7 -2.1 -2.0 1.8 -1.8 -2.2 -1.2 1.7 -1.8 2.1
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.9 -1.4 -1.7 0.0 0.0 -1.3 -1.3 -0.2 -1.2 -1.5 1.7 -1.4 -1.4 -1.1 0.9 -1.4 1.5
Blood clot in the leg (DVT) 0.8 1.0 1.9 1.4 1.0 0.0 0.0 1.1 1.1 0.4 1.1 1.1 -1.2 1.2 1.2 0.8 -0.7 1.1 -1.0
Medication: Paracetamol 0.7 1.2 2.7 -1.6 -1.2 0.0 0.0 -1.1 -1.1 -1.4 -1.0 -1.1 0.8 -1.2 -1.1 -1.3 -0.0 -1.4 1.2
Headache pain in last month 0.1 0.2 0.6 -0.3 0.1 0.0 0.0 -0.5 -0.5 -0.8 -0.5 -0.2 -0.1 -0.1 -0.4 -0.3 0.6 -0.4 0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 7.1 0.1 -0.3 0.0 0.0 -0.0 -0.1 2.7 -0.1 -0.2 0.3 -0.3 0.0 -0.2 -1.6 0.2 -0.1
Glaucoma (self-reported) 0.5 0.6 1.1 0.7 0.9 0.0 0.0 0.8 0.8 0.4 0.8 0.8 -0.9 0.6 0.9 1.0 1.1 0.7 -0.8
Gout (self-reported) 2.1 2.8 5.0 -1.1 -1.9 0.0 0.0 -2.0 -2.0 -2.2 -2.1 -2.0 1.4 -2.0 -1.8 -1.8 0.4 -1.8 2.0
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 4.0 -0.4 -1.4 0.0 0.0 -1.9 -1.8 -1.3 -1.9 -1.8 1.9 -2.0 -1.6 -1.5 -0.2 -1.6 1.9
Medication: Amlodipine 0.7 1.0 2.8 0.9 0.9 0.0 0.0 1.2 1.3 0.1 1.1 1.0 -1.2 1.1 1.0 1.2 1.7 1.0 -1.0
Medication: Ventolin 100micrograms inhaler 3.0 3.9 6.0 0.9 2.2 0.0 0.0 2.3 2.3 2.0 2.3 2.3 -2.0 2.2 2.2 2.3 1.0 2.4 -2.2
Birth weight 2.1 4.5 7.7 1.8 2.6 0.0 0.0 2.2 2.3 1.0 2.2 2.3 -2.8 2.6 2.3 2.8 1.5 2.4 -2.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.2 1.1 1.5 0.0 0.0 1.4 1.4 0.3 1.5 1.4 -1.3 1.3 1.4 1.4 0.1 1.4 -1.4
High blood pressure (siblings) 0.1 0.2 2.0 -1.4 0.0 0.0 0.0 0.2 0.1 -0.6 0.1 0.0 0.3 0.1 -0.1 0.3 0.8 0.1 -0.1
Forced vital capacity (FVC), Best measure 3.0 10.8 17.6 -3.5 -3.6 0.0 0.0 -3.7 -3.8 -1.4 -3.8 -3.6 3.6 -3.4 -3.7 -4.2 -2.1 -3.7 4.1
Body fat percentage 2.3 9.2 34.7 -3.4 -3.0 0.0 0.0 -3.0 -2.9 -5.9 -3.0 -2.9 3.0 -2.9 -2.6 -3.4 0.3 -3.3 3.2
Leg fat percentage (right) 0.9 3.1 19.3 -2.5 -1.5 0.0 0.0 -1.3 -1.2 -4.4 -1.3 -1.3 1.5 -1.3 -1.0 -1.8 0.9 -1.7 1.6
Arm fat-free mass (right) 0.8 4.0 6.6 -1.5 -2.0 0.0 0.0 -2.2 -2.2 -1.9 -2.3 -2.1 2.3 -2.1 -2.4 -2.3 -0.4 -2.6 2.5
Exposure to tobacco smoke outside home 0.3 0.4 1.3 0.1 -0.5 0.0 0.0 -0.8 -0.8 -0.1 -0.8 -0.7 0.9 -0.7 -1.1 -0.2 -0.2 -0.9 0.7
Comparative body size at age 10 0.2 0.4 3.8 -0.3 0.2 0.0 0.0 0.2 0.3 2.0 0.3 0.4 -0.1 0.1 -0.0 -0.0 -1.6 0.1 -0.2
Number of full brothers 0.2 0.2 0.7 -0.6 -0.0 0.0 0.0 0.6 0.5 0.8 0.5 0.3 -0.5 0.4 0.5 0.2 -0.1 0.4 -0.4
Worry too long after embarrassment 5.1 8.6 14.2 -2.6 -3.3 0.0 0.0 -3.2 -3.3 -2.2 -3.3 -3.3 3.6 -3.1 -3.4 -3.2 -1.9 -3.8 3.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 5.2 1.9 1.4 0.0 0.0 1.4 1.4 2.3 1.4 1.4 -1.5 1.5 1.3 1.2 -1.4 1.6 -1.4
Wheeze or whistling in the chest in last year 2.0 3.6 5.9 1.9 2.1 0.0 0.0 2.1 2.3 1.4 2.1 2.2 -2.4 2.1 2.3 1.8 -0.3 2.3 -2.1
Number of children fathered 2.8 3.2 5.0 1.8 1.8 0.0 0.0 2.1 2.1 1.6 2.1 1.9 -2.2 1.8 2.1 1.7 -0.4 2.2 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.2 0.4 0.5 0.0 0.0 0.8 0.7 1.3 0.9 0.8 -0.6 0.4 0.8 0.3 -1.5 0.7 -0.9
Age at first live birth 1.2 2.1 4.2 -0.4 -1.2 0.0 0.0 -1.7 -1.9 -1.4 -1.8 -1.5 1.6 -1.5 -2.1 -1.3 -0.3 -2.0 1.7
Pulse wave peak to peak time 0.5 0.6 1.3 -0.6 0.5 0.0 0.0 1.0 0.9 0.9 1.0 0.8 -1.1 0.8 1.0 0.4 -0.7 0.9 -1.0
Health satisfaction 0.2 0.2 1.0 -0.2 0.1 0.0 0.0 0.6 0.7 -1.0 0.7 0.4 -0.3 0.2 0.4 0.0 -0.6 0.1 -0.5
Shortness of breath walking on level ground 0.4 0.5 2.8 -1.2 -0.6 0.0 0.0 -0.6 -0.6 -1.7 -0.5 -0.5 0.5 -0.6 -0.6 -0.8 -0.7 -0.5 0.6
Qualifications: College or University degree 0.2 0.7 1.2 -0.2 -0.8 0.0 0.0 -1.1 -1.0 0.4 -1.1 -0.9 1.0 -0.7 -0.9 -1.0 -0.9 -0.9 1.0
Eye problems/disorders: None of the above 3.2 3.7 7.0 -2.6 -2.0 0.0 0.0 -2.1 -2.0 -2.4 -2.0 -1.9 1.9 -1.9 -2.0 -2.2 -0.9 -2.0 2.1
Mouth/teeth dental problems: Loose teeth 1.7 2.0 2.9 1.4 1.5 0.0 0.0 1.6 1.6 1.5 1.6 1.5 -1.6 1.7 1.4 1.7 1.3 1.4 -1.3
Emphysema/chronic bronchitis 3.0 3.4 6.1 1.6 2.2 0.0 0.0 2.0 2.1 1.6 2.0 2.1 -2.0 2.5 2.0 2.2 -0.2 2.1 -2.1
Medication for pain relief, constipation, heartburn 1.5 2.6 5.0 1.9 2.2 0.0 0.0 1.7 1.7 1.6 1.6 1.8 -1.6 2.0 1.5 2.1 0.5 1.7 -1.8
Neck or shoulder pain in last month 0.7 1.0 2.0 1.4 1.4 0.0 0.0 1.0 1.0 0.9 0.9 1.4 -1.1 1.3 1.0 0.9 0.0 0.8 -0.9
Medication: Blood pressure 0.3 0.6 3.9 -0.8 -0.3 0.0 0.0 -0.5 -0.5 -2.0 -0.5 -0.5 0.6 -0.3 -0.6 -0.3 1.2 -0.8 0.6
Angina (self-reported) 0.1 0.2 0.8 -0.2 -0.2 0.0 0.0 0.4 0.4 -0.9 0.5 0.2 -0.4 0.3 0.3 0.3 0.9 0.3 -0.2
Migraine (self-reported) 0.3 0.4 1.0 -0.8 0.7 0.0 0.0 0.5 0.6 -0.4 0.5 0.7 -1.0 0.7 0.8 0.3 -0.1 0.7 -0.5
Medication: Ibuprofen 1.0 1.2 2.5 -1.3 -1.1 0.0 0.0 -1.1 -1.1 0.4 -1.1 -1.0 1.3 -1.1 -0.9 -1.6 -1.4 -1.2 1.2
Medication: Allopurinol 1.1 1.4 4.2 -0.6 -1.3 0.0 0.0 -1.3 -1.3 -2.1 -1.4 -1.3 0.9 -1.4 -1.3 -1.2 0.4 -1.2 1.5
Medication: Omeprazole 0.4 0.4 3.1 -0.3 -0.0 0.0 0.0 0.3 0.2 -1.8 0.4 0.1 -0.4 0.2 0.2 0.2 1.7 0.2 -0.1
Medication: Seretide 50 evohaler 1.2 1.4 2.4 0.4 1.2 0.0 0.0 1.3 1.5 1.3 1.2 1.3 -1.4 1.4 1.4 1.2 0.0 1.4 -1.4
Mean time to correctly identify matches 1.4 2.7 4.6 1.0 2.1 0.0 0.0 1.9 1.8 0.7 1.9 2.0 -1.8 2.1 1.8 1.8 -0.6 1.9 -2.0
Heart disease (mother) 0.6 0.7 1.4 0.6 0.8 0.0 0.0 0.9 0.9 -0.8 1.0 0.9 -0.6 0.9 1.0 0.8 1.2 0.9 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.7 -1.1 -1.3 0.0 0.0 -0.7 -0.8 -0.2 -0.7 -1.0 0.9 -1.0 -0.7 -1.0 -1.9 -0.7 0.5
Whole body fat mass 2.4 10.0 30.6 -3.3 -3.1 0.0 0.0 -3.3 -3.1 -5.5 -3.3 -3.2 3.2 -3.1 -3.0 -3.5 0.3 -3.6 3.5
Leg fat mass (right) 1.3 5.2 21.0 -2.6 -2.2 0.0 0.0 -2.1 -2.0 -4.6 -2.1 -2.1 2.2 -2.1 -2.0 -2.5 0.7 -2.6 2.4
Arm predicted mass (right) 0.7 3.8 6.6 -1.5 -1.9 0.0 0.0 -2.2 -2.1 -2.0 -2.3 -2.0 2.3 -2.0 -2.4 -2.1 -0.2 -2.6 2.4
Pulse rate, automated reading 3.1 10.0 16.6 3.2 4.1 0.0 0.0 3.5 3.5 1.5 3.4 3.7 -4.0 3.7 3.0 4.0 2.6 3.0 -3.3
Alcohol intake frequency. 1.5 3.4 6.1 1.2 2.3 0.0 0.0 2.1 2.3 0.6 2.1 2.2 -2.5 2.4 2.0 2.0 1.3 1.9 -1.8
Comparative height size at age 10 7.1 38.9 55.1 -6.0 -6.9 0.0 0.0 -7.0 -7.0 -7.4 -7.2 -6.9 6.7 -6.9 -6.7 -7.0 -2.0 -6.8 7.1
Number of full sisters 7.3 8.8 12.9 2.8 3.3 0.0 0.0 3.4 3.5 2.4 3.5 3.4 -3.2 3.6 3.3 3.3 0.7 3.4 -3.4
Suffer from ‘nerves’ 0.6 0.9 1.9 -0.4 -1.0 0.0 0.0 -1.1 -1.1 -0.5 -1.1 -1.1 1.4 -1.0 -1.1 -1.1 -0.5 -1.1 1.2
Overall health rating 0.1 0.3 0.7 0.3 0.4 0.0 0.0 0.7 0.8 -0.5 0.8 0.6 -0.8 0.6 0.6 0.5 0.4 0.4 -0.5
Chest pain or discomfort 0.9 1.3 2.6 1.3 1.1 0.0 0.0 1.3 1.3 0.6 1.3 1.1 -1.6 1.3 1.1 1.2 1.4 1.3 -0.9
Had major operations 0.1 0.2 0.6 -0.1 -0.5 0.0 0.0 -0.4 -0.3 0.2 -0.4 -0.5 0.6 -0.4 -0.3 -0.5 -0.8 -0.4 0.3
Age at last live birth 0.1 0.2 0.9 0.0 1.0 0.0 0.0 0.4 0.4 -0.3 0.4 0.7 -0.5 0.6 -0.1 0.5 0.3 -0.2 -0.3
Family relationship satisfaction 2.7 3.3 5.1 1.4 1.9 0.0 0.0 2.2 2.3 1.9 2.2 2.2 -2.2 2.2 1.9 1.7 -0.6 1.7 -2.2
Leg pain on walking 0.6 0.8 1.9 0.9 0.8 0.0 0.0 0.8 1.0 -1.4 0.9 0.8 -1.1 0.8 1.2 0.7 0.5 1.3 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.5 -0.8 -0.9 0.0 0.0 -0.9 -1.0 -0.6 -0.8 -0.9 0.9 -1.0 -1.0 -1.2 -1.2 -0.7 0.9
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.2 -1.3 -1.8 0.0 0.0 -1.5 -1.5 -0.4 -1.4 -1.7 1.5 -1.6 -1.5 -1.5 -1.0 -1.2 1.4
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 7.5 2.7 1.4 0.0 0.0 1.5 1.6 2.3 1.4 1.4 -1.3 1.4 1.2 1.6 0.5 1.6 -1.5
Medication: Aspirin 0.2 0.3 0.8 0.7 0.0 0.0 0.0 0.5 0.5 -0.9 0.5 0.2 -0.6 0.3 0.6 0.4 0.8 0.8 -0.3
Supplements: Vitamin C 0.1 0.1 0.9 0.6 -0.1 0.0 0.0 -0.1 -0.0 0.9 -0.1 -0.1 0.6 0.0 -0.1 0.0 -0.5 -0.1 -0.0
Knee pain experienced in last month 0.6 0.9 2.0 1.4 1.2 0.0 0.0 1.0 1.1 0.9 1.1 1.1 -1.0 1.1 0.9 0.9 0.9 0.9 -0.8
Hypertension (Self-reported) 0.4 1.1 8.5 -1.4 -0.6 0.0 0.0 -0.6 -0.6 -2.9 -0.6 -0.6 0.8 -0.3 -0.7 -0.3 1.7 -1.0 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 0.3 0.5 0.0 0.0 0.5 0.4 -0.4 0.6 0.6 -0.8 0.6 0.4 0.3 0.5 0.4 -0.3
Illnesses of father: Heart disease 0.1 0.2 0.8 -0.9 -0.5 0.0 0.0 0.4 0.3 -0.9 0.4 -0.0 -0.1 -0.1 0.3 -0.3 -0.6 0.4 -0.3
Illnesses of siblings: Diabetes 1.3 1.5 3.1 -0.5 -1.8 0.0 0.0 -1.3 -1.2 0.5 -1.3 -1.5 1.0 -1.5 -1.5 -1.7 -1.4 -1.4 1.4
Smoking status: Previous 0.1 0.2 0.4 -0.2 -0.6 0.0 0.0 -0.3 -0.4 -0.3 -0.4 -0.4 0.6 -0.4 -0.1 -0.6 -0.7 -0.4 0.1
Forced expiratory volume in 1-second (FEV1), predicted 9.2 19.1 30.1 -3.7 -4.1 0.0 0.0 -5.2 -5.1 -4.5 -5.1 -4.7 4.8 -4.6 -5.5 -4.4 -0.3 -5.5 5.5
Whole body fat-free mass 0.6 3.6 5.9 -1.2 -1.9 0.0 0.0 -2.2 -2.2 -1.4 -2.3 -2.1 2.2 -2.1 -2.4 -2.1 -0.1 -2.4 2.4
Leg fat-free mass (right) 0.5 2.4 4.2 -0.6 -1.5 0.0 0.0 -1.9 -1.8 -1.4 -1.9 -1.7 1.9 -1.6 -2.0 -1.6 0.0 -2.0 2.0
Arm fat percentage (left) 0.5 2.2 10.9 -1.6 -1.3 0.0 0.0 -1.4 -1.3 -3.3 -1.4 -1.3 1.3 -1.4 -1.1 -1.6 0.5 -1.6 1.5
Average weekly red wine intake 0.1 0.1 1.4 0.5 -0.2 0.0 0.0 -0.2 -0.2 -1.2 -0.3 -0.3 0.2 -0.0 -0.2 -0.2 0.0 -0.5 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.5 -0.7 0.0 0.0 -0.4 -0.5 0.8 -0.4 -0.6 0.5 -0.6 -0.4 -0.5 -0.1 -0.1 0.5
Mood swings 0.2 0.3 1.1 0.1 0.6 0.0 0.0 0.7 0.6 -0.4 0.8 0.7 -0.3 0.4 0.7 0.2 -1.1 0.2 -0.7
Loneliness, isolation 0.2 0.3 1.9 0.5 -0.2 0.0 0.0 -0.1 -0.0 1.4 -0.1 -0.1 0.3 0.0 -0.3 -0.4 -1.1 -0.7 0.3
Long-standing illness, disability or infirmity 0.4 0.6 1.1 1.0 0.7 0.0 0.0 0.7 0.8 -0.5 0.8 0.7 -0.8 0.9 1.0 0.9 1.1 0.8 -0.7
Ever had bowel cancer screening 0.2 0.2 1.4 0.8 -0.1 0.0 0.0 0.2 0.2 1.1 0.2 0.0 -0.1 0.4 0.2 0.0 -1.2 0.2 -0.2
Diabetes diagnosed by doctor 0.4 0.6 1.7 -0.1 -0.8 0.0 0.0 -0.9 -0.9 -0.6 -0.9 -0.8 0.6 -0.7 -1.3 -0.7 0.0 -1.3 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.7 1.1 0.7 0.0 0.0 0.7 0.8 1.7 0.7 0.8 -0.8 0.6 0.4 0.6 -1.1 0.8 -0.8
Friendships satisfaction 0.3 0.4 2.3 1.3 0.6 0.0 0.0 0.1 0.3 1.5 0.1 0.4 -0.2 0.5 -0.2 0.3 -0.8 -0.3 -0.2
Qualifications: nursing, teaching 1.6 2.5 4.2 -0.7 -1.3 0.0 0.0 -2.0 -1.9 -1.1 -2.1 -1.6 2.0 -1.4 -1.8 -1.7 -1.9 -1.8 1.8
Commuting to job workplace: Walk 2.8 3.1 4.5 1.7 2.1 0.0 0.0 1.9 1.9 1.5 1.9 2.0 -1.6 2.1 1.9 2.1 1.8 1.9 -1.8
Eye problems/disorders: Cataract 0.1 0.1 0.9 0.9 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.1 -0.2 0.1 -0.0 0.4 0.6 0.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.3 -0.3 -0.0 0.0 0.0 0.1 -0.0 0.3 0.0 0.0 -0.2 -0.1 -0.2 -0.1 -0.6 -0.4 -0.1
Medication for cholesterol 0.3 0.4 1.1 -0.4 -0.7 0.0 0.0 -0.6 -0.7 0.4 -0.6 -0.7 0.5 -0.9 -0.4 -0.8 -1.0 -0.3 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 0.1 0.0 0.0 0.0 0.6 0.6 0.8 0.6 0.5 -0.5 0.2 0.5 0.0 -0.7 0.3 -0.5
Back pain experienced in last month 1.8 2.6 4.9 -0.1 -1.5 0.0 0.0 -1.8 -1.7 -1.3 -1.8 -1.5 1.7 -1.9 -2.0 -2.2 -1.5 -2.1 2.0
Mineral and other dietary supplements 0.3 0.4 1.1 0.3 0.8 0.0 0.0 0.7 0.5 0.7 0.7 0.9 -0.8 0.8 0.3 0.3 -1.1 0.2 -0.7
Breast cancer (self-reported) 0.4 0.5 4.2 0.6 0.4 0.0 0.0 0.5 0.6 -0.4 0.5 0.2 -0.9 0.5 0.3 0.9 2.1 0.4 -0.4
Asthma (self-reported) 0.6 1.1 1.9 1.1 1.3 0.0 0.0 1.1 1.1 1.3 1.1 1.2 -1.1 1.2 1.2 1.1 -0.2 1.4 -1.1
Osteoporosis (self-reported) 0.0 0.1 0.4 -0.1 -0.3 0.0 0.0 -0.2 -0.3 0.2 -0.1 -0.3 0.6 -0.2 -0.2 -0.0 -0.3 -0.0 0.1
Osteoarthritis (self-reported) 1.2 1.6 3.3 -0.3 -1.5 0.0 0.0 -1.4 -1.3 0.1 -1.4 -1.3 1.2 -1.3 -1.5 -1.8 -1.3 -1.5 1.7
Medication: Aspirin 0.2 0.3 1.2 0.9 -0.1 0.0 0.0 0.4 0.4 -1.1 0.4 0.1 -0.5 0.1 0.5 0.4 1.1 0.5 -0.3
Medication: Gliclazide 0.1 0.2 1.0 -0.7 -0.1 0.0 0.0 0.1 0.0 0.9 0.0 0.1 0.3 0.1 -0.3 0.0 -1.0 -0.2 -0.1
Illnesses of father: None of the above (group 1) 0.1 0.1 1.0 1.0 0.4 0.0 0.0 0.2 0.1 0.6 0.1 0.2 -0.4 0.1 0.1 0.5 0.3 0.3 -0.2
Smoking status: Current 0.4 0.6 1.1 0.6 0.8 0.0 0.0 0.9 1.1 -0.2 1.0 0.9 -0.9 0.9 1.0 0.8 -0.0 1.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.5 -1.6 -0.8 0.0 0.0 -0.5 -0.6 -0.2 -0.5 -0.5 0.8 -0.6 -0.6 -0.8 0.4 -0.8 0.7
Whole body water mass 0.6 3.5 5.8 -1.3 -1.9 0.0 0.0 -2.2 -2.1 -1.5 -2.3 -2.1 2.2 -2.0 -2.4 -2.0 -0.1 -2.4 2.4
Leg predicted mass (right) 0.4 2.4 4.1 -0.6 -1.5 0.0 0.0 -1.8 -1.8 -1.3 -1.9 -1.7 1.8 -1.6 -2.0 -1.6 0.0 -2.0 2.0
Arm fat mass (left) 0.9 3.6 11.6 -2.2 -1.9 0.0 0.0 -1.9 -1.8 -3.4 -1.9 -1.9 1.9 -1.9 -1.8 -2.1 0.4 -2.2 2.1
Number of self-reported non-cancer illnesses 0.2 0.3 2.9 0.4 -0.3 0.0 0.0 -0.3 -0.3 -1.7 -0.3 -0.3 -0.1 -0.1 -0.3 -0.3 0.7 -0.4 0.4
Average weekly champagne plus white wine intake 1.6 2.2 3.7 -1.9 -1.5 0.0 0.0 -1.9 -1.9 -0.6 -1.8 -1.7 1.9 -1.7 -1.5 -1.5 -0.4 -1.7 1.6
Miserableness 0.1 0.2 1.6 -0.3 -0.2 0.0 0.0 -0.3 -0.3 -0.7 -0.2 -0.2 0.5 -0.2 -0.5 -0.4 -1.2 -0.6 0.4
Guilty feelings 2.0 3.0 5.0 -1.6 -2.2 0.0 0.0 -1.7 -1.7 -1.1 -1.7 -1.9 2.2 -1.8 -1.8 -2.0 -2.1 -2.0 1.7
Wears glasses or contact lenses 0.1 0.1 0.5 0.7 0.3 0.0 0.0 -0.0 0.2 0.5 -0.1 0.1 0.2 0.3 -0.1 0.1 -0.4 -0.2 -0.0
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.4 0.1 0.0 0.0 0.3 0.4 -0.4 0.4 0.2 -0.2 0.2 0.0 0.3 0.2 -0.1 -0.3
Hearing aid user 0.3 0.4 1.1 0.3 -0.6 0.0 0.0 -0.7 -0.5 0.1 -0.7 -0.5 0.9 -0.7 -0.6 -0.8 -0.3 -1.1 0.6
Mother’s age at death 0.2 0.3 0.7 0.3 0.4 0.0 0.0 0.7 0.8 0.1 0.7 0.5 -0.7 0.5 0.6 0.5 0.1 0.9 -0.6
Financial situation satisfaction 0.1 0.2 2.1 1.4 0.0 0.0 0.0 0.0 -0.1 0.4 0.0 0.0 0.0 -0.1 -0.3 -0.0 -0.6 0.0 0.0
Tinnitus: Yes, now most or all of the time 4.9 5.8 9.2 2.8 2.7 0.0 0.0 2.7 2.6 1.1 2.6 2.6 -2.2 2.6 2.7 3.0 2.4 2.6 -2.7
Commuting to job workplace: Public transport 0.1 0.1 0.4 0.6 0.4 0.0 0.0 0.2 0.3 -0.1 0.2 0.4 -0.4 0.5 0.4 0.2 0.6 0.1 -0.2
Eye problems/disorders: Glaucoma 0.6 0.8 1.4 0.9 1.2 0.0 0.0 1.0 0.9 1.2 1.0 1.0 -0.9 0.8 0.8 1.1 0.7 0.5 -1.0
Medication: Blood pressure 0.3 0.6 4.8 -0.6 -0.3 0.0 0.0 -0.4 -0.3 -1.6 -0.3 -0.3 0.8 -0.0 -0.4 0.3 2.2 -0.4 0.3
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.6 -0.4 -1.3 0.0 0.0 -1.1 -1.0 -0.5 -1.0 -1.2 1.0 -1.2 -0.9 -1.1 0.8 -0.9 1.2
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.7 -0.3 -0.8 0.0 0.0 -0.5 -0.4 -0.4 -0.5 -0.8 0.7 -0.8 -0.2 -0.3 0.8 0.0 0.5
High cholesterol (Self-reported) 0.4 0.7 1.2 0.4 0.5 0.0 0.0 1.1 1.1 -0.3 1.1 0.8 -0.8 1.0 1.1 0.9 0.2 1.0 -1.1
Medication: Bendroflumethiazide 0.4 0.6 1.8 1.3 0.8 0.0 0.0 0.8 0.9 -0.7 0.8 0.7 -0.7 0.9 0.5 0.9 1.3 0.6 -0.6
Medication: Paracetamol 0.6 0.9 1.7 -0.7 -1.2 0.0 0.0 -0.9 -0.9 -0.9 -0.9 -1.0 0.9 -1.0 -1.0 -1.1 -0.5 -1.3 1.1
Medication: Lisinopril 0.3 0.4 2.0 -0.9 0.0 0.0 0.0 -0.5 -0.4 -1.4 -0.5 -0.2 0.5 -0.1 -0.4 -0.2 1.1 -0.5 0.6
Medication: Atorvastatin 1.5 1.8 2.9 1.0 1.2 0.0 0.0 1.7 1.7 0.6 1.7 1.5 -1.7 1.6 1.6 1.4 0.4 1.6 -1.6
Illnesses of father: High blood pressure 2.7 3.3 6.2 -2.1 -1.8 0.0 0.0 -2.1 -2.0 -1.0 -2.0 -1.9 1.8 -1.8 -2.3 -2.0 -1.3 -2.5 2.0
Alcohol drinker status: Never 0.0 0.1 0.4 -0.6 -0.1 0.0 0.0 -0.1 0.1 0.4 -0.0 -0.1 0.2 -0.0 0.1 -0.2 -0.3 -0.1 0.2
Ever smoked 0.0 0.0 0.1 -0.0 -0.3 0.0 0.0 -0.1 -0.0 0.0 -0.1 -0.2 0.4 -0.1 0.1 -0.1 -0.1 0.0 -0.1
Basal metabolic rate 1.1 6.0 9.3 -2.0 -2.5 0.0 0.0 -2.8 -2.7 -2.5 -2.9 -2.7 2.8 -2.6 -2.9 -2.7 -0.1 -3.0 3.0
Leg fat percentage (left) 0.8 3.0 19.1 -2.5 -1.4 0.0 0.0 -1.3 -1.2 -4.4 -1.2 -1.2 1.6 -1.3 -1.0 -1.8 0.7 -1.7 1.5
Arm fat-free mass (left) 0.7 3.7 6.0 -1.8 -2.0 0.0 0.0 -2.1 -2.1 -1.9 -2.1 -2.0 2.3 -2.1 -2.3 -2.2 -0.3 -2.5 2.4
Number of operations (self-reported) 0.0 0.0 0.3 0.3 -0.2 0.0 0.0 0.1 0.1 0.5 0.1 -0.1 -0.1 -0.0 0.3 0.2 0.2 0.1 -0.2
Average weekly beer plus cider intake 0.8 1.1 2.1 -1.1 -1.3 0.0 0.0 -1.2 -1.2 -0.6 -1.1 -1.3 0.8 -1.4 -1.5 -1.1 -0.4 -1.4 1.2
Irritability 0.9 1.5 2.4 0.9 -0.9 0.0 0.0 -1.6 -1.5 -1.1 -1.5 -1.3 1.5 -1.3 -1.6 -0.8 0.3 -1.4 1.5
Risk taking 1.1 1.6 2.6 1.2 1.4 0.0 0.0 1.4 1.4 1.0 1.3 1.4 -1.4 1.4 1.5 1.3 -0.6 1.6 -1.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.8 -0.5 -0.5 0.0 0.0 -0.5 -0.5 0.9 -0.6 -0.5 0.8 -0.4 -0.3 -0.5 -1.3 -0.5 0.4
Fractured/broken bones in last 5 years 0.1 0.1 0.5 -0.1 -0.2 0.0 0.0 0.4 0.4 -0.7 0.4 0.2 -0.1 -0.0 0.7 -0.0 0.2 0.4 -0.4
Age started oral contraceptive pill 2.8 3.5 5.8 0.9 2.3 0.0 0.0 2.2 2.2 1.0 2.2 2.3 -1.7 2.1 2.1 2.3 0.8 2.1 -2.4
Diastolic blood pressure, automated reading 1.2 3.6 6.4 -1.5 -2.0 0.0 0.0 -1.9 -2.1 -2.5 -2.1 -2.3 2.2 -2.0 -2.1 -1.2 1.8 -2.3 2.0
Ever depressed for a whole week 2.1 2.6 5.3 1.6 1.9 0.0 0.0 1.7 1.7 0.6 1.8 1.8 -1.9 1.8 2.3 1.6 0.5 2.2 -1.8
Unable to work because of sickness or disability 0.5 0.7 1.7 0.4 0.5 0.0 0.0 0.9 1.0 1.1 1.0 0.9 -1.1 0.8 0.9 0.1 -1.3 0.8 -0.8
Commuting to job workplace: Cycle 0.1 0.1 1.7 -0.1 -0.2 0.0 0.0 0.0 -0.0 0.2 -0.0 -0.0 0.1 -0.1 0.3 -0.4 -1.3 0.3 -0.2
Myopia 0.3 0.4 0.9 0.2 0.7 0.0 0.0 0.6 0.7 0.8 0.7 0.8 -0.3 0.9 0.9 0.4 -0.7 0.5 -0.8
Vascular/heart problems diagnosed by doctor 0.7 1.9 10.6 1.1 1.1 0.0 0.0 1.0 1.0 3.3 1.1 1.1 -1.2 0.9 1.3 0.6 -2.1 1.4 -1.2
Cholesterol lowering medication 0.8 1.1 2.1 0.8 1.0 0.0 0.0 1.4 1.2 0.2 1.4 1.2 -1.1 1.0 1.0 1.4 1.4 1.0 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.1 -0.9 -1.0 0.0 0.0 -0.8 -0.9 -1.4 -0.7 -0.9 0.7 -0.9 -0.9 -0.8 1.2 -0.7 1.0
Pain experienced in last month 0.1 0.2 0.6 -0.3 0.2 0.0 0.0 0.5 0.3 0.1 0.6 0.2 -0.1 0.1 0.5 0.6 0.1 0.7 -0.8
Supplements: Calcium 0.8 0.9 2.1 1.5 1.0 0.0 0.0 1.1 1.1 0.1 1.1 1.0 -1.1 0.9 1.0 0.9 0.4 1.2 -1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 0.7 0.3 0.0 0.0 0.1 0.2 -0.1 0.1 0.2 -0.6 0.4 0.4 -0.1 -0.4 0.6 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.0 -0.9 0.0 0.0 -0.8 -0.7 -0.7 -0.8 -0.9 0.6 -0.6 -0.6 -0.7 0.4 -0.8 0.9
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 2.1 1.4 0.9 0.0 0.0 1.0 1.0 0.5 1.0 1.0 -1.1 1.1 1.0 0.6 -0.7 1.1 -0.9
Heart disease (siblings) 0.1 0.1 0.6 -0.4 -0.8 0.0 0.0 0.1 -0.0 -0.5 0.1 -0.3 0.2 -0.3 -0.1 -0.4 -0.5 0.5 0.0
Alcohol drinker status: Previous 0.6 0.6 1.7 0.5 1.0 0.0 0.0 0.9 1.0 -0.5 0.9 0.9 -1.3 1.0 0.9 0.7 -0.2 0.8 -0.8
Pack years of smoking 0.1 0.1 0.9 1.0 -0.1 0.0 0.0 -0.3 -0.2 -0.3 -0.2 -0.3 0.4 -0.3 -0.2 0.1 0.6 -0.3 0.3
Impedance of whole body 4.6 23.5 51.7 -5.1 -5.1 0.0 0.0 -5.2 -5.2 -7.2 -5.2 -5.1 5.0 -5.0 -4.8 -5.5 -1.3 -5.4 5.4
Leg fat mass (left) 1.3 5.2 21.2 -2.6 -2.2 0.0 0.0 -2.1 -2.1 -4.6 -2.1 -2.1 2.3 -2.1 -2.0 -2.5 0.7 -2.6 2.5
Arm predicted mass (left) 0.6 3.3 5.4 -1.7 -1.8 0.0 0.0 -1.9 -1.9 -2.1 -2.0 -1.8 2.1 -1.9 -2.1 -2.1 -0.2 -2.3 2.1