Hub : Genes

ZSCAN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0290	0.0160	0.01000	0.024	0.014	0.022	0.017	0.022	0.00058	0.00730	0.00097	0.0031	0.00099
2	GTEx	Artery Tibial	0.0485	0.0229	0.00610	0.014	NA	0.007	NA	0.014	0.02700	NA	0.09200	NA	0.02400
3	GTEx	Lung	0.0941	0.0393	0.00200	0.001	NA	0.001	NA	0.008	0.26000	NA	0.25000	NA	0.07600
4	GTEx	Skin Sun Exposed Lower leg	0.0850	0.0350	0.00082	0.021	NA	0.030	NA	0.025	0.00710	NA	0.00140	NA	0.00330
5	GTEx	Thyroid	0.0550	0.0270	0.00560	0.032	NA	0.011	NA	0.028	0.00170	NA	0.04500	NA	0.00290
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.1129	0.0516	0.00034	-0.002	0.033	0.030	NA	0.008	0.62000	0.00011	0.00024	NA	0.03600
7	TCGA	Liver Hepatocellular Carcinoma	0.0550	0.0330	0.00930	0.012	0.024	0.005	NA	0.007	0.08100	0.02700	0.18000	NA	0.15000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	9.0	14.3	19.5	3.6	-2.7	-4.0	-4.3	-4.2	-2.8	-4.4
Bipolar Disorder or Schizophrenia	12.5	30.6	44.9	5.2	-4.0	-5.7	-6.0	-6.6	-3.7	-6.7
Depressed Affect (Nagel 2018)	0.4	0.8	3.2	0.4	0.5	1.0	0.4	1.8	0.2	0.9
Depression (Nagel 2018)	0.2	0.4	1.2	-0.0	-1.1	0.3	0.7	0.2	0.7	0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.7	-0.5	-0.9	0.5	1.2	1.2	0.9	1.3
Neuroticism (Nagel 2018)	0.4	0.8	3.1	-0.3	0.8	0.3	0.5	1.7	-0.5	1.3
Schizophrenia (2018)	8.0	16.5	26.2	3.7	-3.0	-4.1	-4.2	-5.1	-2.5	-5.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.3	-0.3	-0.3	0.2	-0.7	0.4	0.2
Worry (Nagel 2018)	0.2	0.4	0.8	-0.6	0.9	-0.4	0.0	0.6	-0.9	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	2.3	0.1	-1.4	-0.0	-1.0	-0.7	-1.5	0.0
Alzheimer’s Disease (in father)	0.8	0.8	1.7	1.3	-1.1	-0.7	-0.6	-0.8	-0.4	-1.1
Alzheimer’s Disease (including proxy)	1.7	2.5	5.1	1.0	-2.3	-0.8	-1.7	-1.5	-2.2	-1.1
Crohns Disease (2017)	1.2	2.6	6.2	2.4	-1.3	-0.6	-2.5	-0.7	0.7	-1.7
Irritable Bowel Disease (IBD)	0.8	2.0	7.2	2.2	-0.4	0.0	-2.7	-0.3	0.0	-1.3
Ulcerative Colitis (UC)	0.3	0.6	2.1	0.8	0.9	0.5	-1.4	0.3	-0.7	-0.2
Major Depression (MDD)	2.2	2.6	4.0	1.9	-1.5	-1.3	-1.5	-2.0	1.4	-1.7
Reaction Time	0.3	0.5	2.0	-0.3	-0.4	-0.7	-1.4	-0.1	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.3	-0.9	0.5	-0.3	1.8	1.3	0.4	1.5
Breast Cancer	0.3	0.8	3.0	-0.6	0.4	-0.8	0.9	0.3	1.7	0.6
Ovarian Cancer	0.1	0.1	0.2	-0.2	0.5	-0.2	0.4	0.1	0.3	0.2
Prostate Cancer	0.3	0.4	1.3	-0.9	1.2	0.2	-0.3	0.6	-0.3	0.7
Age at First Birth	0.2	0.3	1.0	0.5	0.3	0.7	-1.0	0.5	0.4	0.1
Bipolar Disorder (2011)	5.2	5.0	10.1	1.6	-2.0	-1.9	-2.2	-3.2	-1.7	-2.6
Body Mass Index (BMI) (2010)	0.5	0.7	2.8	-0.3	0.0	-1.2	-0.5	-0.3	-1.7	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.6	0.4	-0.7	-1.0	-0.6	0.0	-0.7
Crohns Disease (2012)	0.2	0.3	1.0	0.6	-0.5	-0.5	-1.0	-0.0	0.2	-0.5
Mean Putamen Volume	3.4	3.9	7.5	2.6	-2.6	-1.2	-1.0	-1.5	-1.2	-2.7
Fasting Glucose	1.1	1.3	3.1	-1.1	0.9	1.4	1.7	1.1	0.5	0.6
HbA1C	1.4	1.5	2.6	-0.8	1.0	1.5	1.6	1.2	1.2	1.1
HDL Cholesterol	0.5	0.9	2.0	1.4	-0.2	-0.1	-1.3	-0.7	-0.1	-1.4
LDL Cholesterol	1.5	2.4	6.8	1.7	-1.6	-2.6	-1.4	-1.2	-0.7	-0.9
Lupus	1.5	2.2	5.2	2.3	-1.4	-0.5	-2.2	-1.4	0.2	-1.3
Neuroticism (2016)	0.4	0.6	1.8	-0.5	-0.5	-1.3	0.2	-0.7	-1.2	0.2
Primary Biliary Cirrhosis	0.3	0.5	1.1	-1.1	0.7	-0.5	0.0	0.4	-0.8	0.8
Rheumatoid Arthritis	1.1	1.5	5.6	-0.6	2.4	0.0	1.3	1.4	-0.3	1.1
Schizophrenia (2014)	6.8	15.0	22.9	3.6	-3.2	-4.2	-3.8	-4.8	-2.3	-4.7
Triglycerides	0.3	0.6	2.1	-0.1	-0.2	-1.4	0.8	-1.1	0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.6	-0.2	-0.5	-1.3	0.3	0.4	-0.8	0.4
Ulcerative Colitis	0.6	0.9	3.7	-0.0	-0.3	0.3	-1.9	0.1	-1.6	0.3
Blood Eosinophil Count	2.6	20.1	34.9	5.7	-2.4	-3.2	-5.2	-5.3	-1.2	-5.9
Blood Platelet Count	1.8	20.8	36.6	6.1	-5.9	-1.4	-5.5	-3.2	-2.3	-5.2
Blood Red Count	0.7	6.5	11.6	-1.8	2.3	1.9	2.5	2.6	3.0	3.4
Blood White Count	0.9	6.5	14.1	3.8	-2.6	-2.2	-1.0	-2.4	1.6	-3.2
Heel T-Score	1.9	15.0	32.4	2.4	-2.2	-5.7	-3.6	-4.7	-3.3	-4.2
BMI	0.4	2.3	11.6	-0.5	0.5	-0.4	3.4	1.7	0.8	0.7
Height	4.7	90.0	163.8	-5.8	4.1	6.5	12.8	10.7	12.3	10.4
Waist Hip Ratio (WHR)	2.4	10.9	43.5	-1.8	2.4	1.8	2.6	2.0	6.6	3.2
Systolic Blood Pressure	0.5	2.3	8.4	-1.5	0.8	-1.7	2.9	0.5	0.7	0.9
Smoking Status	0.3	0.7	2.6	0.2	-0.9	1.0	-0.2	0.2	-1.6	0.2
Allergy or Eczema	1.7	4.4	6.8	2.3	-2.6	-0.9	-2.1	-2.2	-1.8	-2.2
Cardiovascular Disease	1.2	4.1	12.8	-2.5	1.0	-0.5	3.6	1.9	0.1	2.2
Hypothyroidism (self reported)	2.6	6.0	11.9	-2.3	2.8	1.3	3.5	2.0	1.6	2.8
Respiratory disease	1.1	2.4	5.8	1.6	-2.4	-1.1	-2.3	-0.5	-0.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.5	-1.1	0.6	0.6	0.8	1.9	1.1	1.7
Lung FEV1/FVC ratio	3.1	15.7	57.3	-1.8	1.7	0.0	7.6	2.8	5.4	3.0
Lung FVC	0.3	1.7	4.2	2.0	1.1	0.9	-0.5	0.3	1.6	-1.8
Neuroticism	0.4	1.0	3.7	-0.4	0.6	0.7	0.7	1.9	0.2	1.2
Chronotype (morning person)	2.3	5.3	8.0	-2.5	2.1	2.6	2.1	2.8	-1.4	2.4
Hair Pigment	0.0	1.1	5.5	0.2	0.1	1.1	0.2	2.3	-0.0	1.1
Tanning	0.0	0.5	2.1	-0.0	0.1	0.9	-0.7	0.4	-1.4	0.3
Hand grip strength (left)	1.9	5.0	9.0	3.0	-1.9	-0.8	-2.1	-2.0	2.4	-2.7
Number of treatments/medications taken	0.2	0.4	1.3	-0.0	-0.7	-0.2	0.9	0.4	1.2	0.2
Average weekly spirits intake	0.5	0.7	2.2	0.0	-0.6	-1.5	-0.1	-0.3	-1.4	-0.1
Sensitivity / hurt feelings	0.6	1.0	2.6	1.2	0.6	-1.6	-0.9	-0.4	-0.5	-1.2
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.6	-1.8	0.1	1.2	2.4	1.2	0.5	1.6
Hearing difficulty/problems: Yes	5.8	8.8	19.0	4.4	-3.5	-3.2	-1.8	-2.3	0.3	-3.3
Relative age of first facial hair	1.9	3.9	9.0	-1.3	1.1	1.6	3.0	2.3	1.8	2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	1.2	-0.7	0.1	0.1	0.8	1.4	-0.2
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.3	1.2	-1.7	-1.2	-2.3	-2.0	-1.7	-1.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	0.2	0.1	-0.7	0.8	-0.1	1.0	0.3
Systolic blood pressure, automated reading	0.3	1.0	4.4	-0.4	-0.6	-2.1	0.8	-1.1	-0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.3	-0.5	-0.0	-0.1	0.1	0.5	0.2
Angina	0.7	0.9	2.7	-0.9	1.6	0.6	0.1	0.2	1.5	0.5
Medication for hormone replacement therapy	1.3	1.4	2.6	1.4	-1.5	-1.6	-1.1	-0.5	-0.5	-1.2
Vitamin and mineral supplements	1.1	1.4	4.7	-0.5	0.3	-0.4	2.2	1.7	0.8	1.1
Supplements: Zinc	0.2	0.2	0.7	-0.5	-0.3	-0.8	0.3	-0.2	-0.1	0.0
Medication: Co-codamol	2.3	2.6	4.6	-2.1	1.8	0.8	1.7	1.8	-0.3	1.8
Medication: Metformin	0.2	0.3	0.9	0.1	0.1	0.5	0.5	1.0	0.9	0.5
Diabetes (father)	1.5	1.8	5.3	-0.5	1.2	0.2	2.0	2.3	0.2	1.3
Diabetes (mother)	0.3	0.4	0.7	0.8	0.2	-0.6	0.5	0.5	0.7	-0.7
Severe depression (siblings)	1.0	1.2	5.2	0.3	0.5	-0.7	-0.5	-2.3	-0.5	-1.3
Pack years adult smoking proportion	1.3	1.9	3.8	-1.5	1.9	0.8	1.4	0.2	1.7	1.3
Impedance of leg (right)	4.9	23.7	68.9	-1.5	5.0	-1.3	5.6	3.5	8.3	5.0
Leg fat-free mass (left)	0.9	4.8	11.5	-1.6	-0.7	2.7	3.4	2.7	1.2	1.7
Trunk fat percentage	3.9	15.5	40.7	-1.0	2.4	-1.1	6.4	3.6	6.0	3.3
Hand grip strength (right)	1.0	2.8	8.8	2.2	-0.8	0.2	-1.6	-0.8	3.0	-1.4
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.8	-0.6	-0.2	1.0	0.5	-0.2	0.5
Current tobacco smoking	0.5	0.9	2.3	0.9	-0.8	-0.3	-0.7	-1.5	0.3	-1.3
Average weekly fortified wine intake	0.7	0.8	1.8	-1.4	0.2	0.2	0.3	0.8	-1.3	1.0
Maternal smoking around birth	0.5	0.7	2.7	1.1	-0.4	0.6	-0.4	-0.5	1.6	-0.5
Fed-up feelings	2.5	4.5	9.5	-1.6	1.1	1.7	3.1	2.7	1.4	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	-0.8	-0.1	0.5	1.3	0.8	0.8	1.3
Relative age voice broke	0.5	0.7	2.5	-0.2	0.4	-0.6	1.4	-0.1	1.6	0.4
Taking other prescription medications	0.6	0.9	2.5	1.3	-1.0	-0.8	0.1	0.0	1.6	-0.7
Age when periods started (menarche)	2.5	5.9	10.7	3.3	-1.8	-1.4	-3.1	-2.3	0.1	-3.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	0.8	-1.0	-1.3	-0.3	-0.9	-0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.6	0.3	-1.7	-1.6	0.0	-1.5	-2.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.5	0.2	0.1	-0.0	0.2	0.9	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.1	-0.4	-0.1	-0.3	-0.2	-0.4	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	2.2	-0.5	-0.0	0.4	1.5	0.5	0.9	0.5
High blood pressure	0.6	1.8	6.9	-1.5	0.2	-0.3	2.6	1.1	-0.2	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.1	0.9	-1.7	0.4	-1.8	-0.4	-1.7	-0.7
Multivitamins +/- minerals	1.3	1.6	4.3	1.0	-0.3	0.1	-2.1	-1.9	-0.1	-1.5
Stomach or abdominal pain in last month	0.2	0.2	0.8	0.2	-0.9	-0.0	-0.6	-0.4	-0.2	0.1
Supplements: Glucosamine	2.4	3.1	6.6	-1.0	1.2	2.6	1.3	2.4	1.2	1.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.4	-0.5	1.2	0.8	1.1	1.2	-0.0	0.9
Medication: Atenolol	0.7	0.9	2.0	-0.6	-1.0	-0.8	0.9	-1.3	-1.4	-0.2
Medication: Levothyroxine sodium	1.5	2.6	7.1	-1.4	2.7	0.7	1.8	1.3	0.9	1.7
Sitting height	3.0	21.1	39.8	-3.4	2.7	2.7	6.3	5.2	4.8	5.5
Chronic bronchitis/emphysema (father)	2.3	2.8	4.3	1.4	-1.5	-1.7	-2.0	-2.1	-1.2	-1.6
High blood pressure (mother)	0.4	0.5	2.2	0.4	0.5	-1.5	-0.1	-0.4	-0.5	-0.7
Body mass index (BMI)	0.3	1.4	3.9	1.2	-0.9	-2.0	1.2	-0.5	-0.0	-1.4
Impedance of leg (left)	4.7	22.8	69.2	-1.4	5.1	-0.7	5.3	3.4	8.3	4.7
Leg predicted mass (left)	0.9	4.7	11.3	-1.5	-0.8	2.7	3.4	2.7	1.1	1.7
Trunk fat mass	3.7	15.7	43.4	-1.2	1.9	-0.4	6.6	4.0	5.8	3.4
Waist circumference	1.8	6.6	19.3	-0.2	1.0	-1.3	4.4	2.0	4.3	1.4
Number of incorrect matches in round	2.1	3.4	8.1	1.6	-0.7	-1.3	-2.8	-2.0	-1.6	-2.2
Past tobacco smoking	0.1	0.2	0.5	-0.7	0.5	0.4	0.4	-0.1	0.5	0.2
Alcohol usually taken with meals	0.6	1.0	4.0	0.1	-1.5	0.1	-0.4	-0.5	-2.0	-0.4
Nervous feelings	0.4	0.8	1.9	0.3	-0.6	-0.9	-1.2	-0.7	-1.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	5.0	0.9	-2.2	0.1	-0.5	0.2	0.4	-0.5
Hearing difficulty/problems with background noise	3.1	4.9	8.7	2.6	-3.0	-2.0	-1.9	-2.3	0.7	-2.3
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	0.0	-0.0	1.0	-1.5	0.9	-1.1	0.5
Had menopause	6.6	8.2	15.1	3.6	-2.0	-3.0	-1.8	-3.7	-0.4	-3.9
Had other major operations	0.8	1.0	4.3	0.7	0.9	0.7	0.7	0.4	2.1	0.0
Forced vital capacity (FVC)	2.7	10.3	34.0	-0.6	2.0	2.6	3.1	3.5	5.8	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.5	0.7	-1.3	-0.8	-0.4	-1.0	-1.6	-0.6
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.4	0.8	-1.1	-0.7	-0.5	-0.9	-1.5	-0.9
Qualifications: None of the above	0.5	1.1	2.5	1.0	0.8	-1.6	-0.7	-1.2	0.6	-1.0
Financial difficulties in last 2 years	0.0	0.1	0.2	-0.2	-0.2	0.4	-0.3	-0.3	0.1	0.1
Mouth/teeth dental problems	0.5	0.8	3.2	0.1	0.5	1.1	0.2	0.5	1.8	0.8
Heart attack	0.5	0.7	1.3	-0.5	0.5	1.1	0.6	0.9	0.9	1.2
Allergy	1.6	3.6	9.2	-1.9	3.0	0.3	2.5	1.1	1.5	1.7
Pain all over the body in last month	0.5	0.6	1.2	1.0	0.3	-0.5	-0.7	1.0	1.1	-0.1
Diabetes (self-reported)	0.1	0.2	0.8	0.0	-0.4	0.6	0.2	0.9	0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.8	-1.3	0.8	0.7	1.1	1.2	-0.5	1.3
Medication: Ramipril	0.2	0.2	0.7	-0.1	0.0	-0.8	0.5	-0.8	-0.2	-0.4
Medication: Simvastatin	0.5	0.8	2.1	0.4	-1.5	-1.0	0.9	-0.8	0.6	-0.8
Fluid intelligence score	1.2	2.5	5.2	-1.4	1.3	-0.2	2.3	1.9	0.8	2.0
Illnesses of siblings	0.4	0.6	2.8	-0.2	-0.8	1.7	0.4	0.4	-0.3	0.5
Neuroticism score	0.2	0.5	1.8	0.1	-0.1	0.7	0.7	1.3	0.6	0.8
Weight	2.1	10.3	32.8	-1.1	0.8	0.7	5.7	3.4	4.3	2.5
Impedance of arm (right)	2.8	13.3	31.1	-1.8	3.4	0.2	4.0	3.4	5.6	4.4
Arm fat percentage (right)	0.8	3.1	9.7	0.3	0.4	-2.3	3.1	1.2	2.2	0.6
Trunk fat-free mass	0.8	4.7	11.9	-1.4	-0.9	2.6	3.5	2.6	1.6	1.7
Hip circumference	1.7	7.4	27.7	-0.3	0.8	-1.4	5.3	2.5	3.6	1.7
Time employed in main current job	0.7	0.8	2.7	0.1	1.6	-0.8	-1.0	-0.8	0.1	-0.5
Alcohol intake versus 10 years previously	0.7	1.1	2.9	-0.2	1.1	1.7	0.4	0.8	1.3	0.9
Father’s age at death	0.4	0.5	1.3	0.8	-0.0	0.5	-0.8	-1.1	-0.2	-0.7
Worrier / anxious feelings	0.1	0.2	0.8	0.3	0.3	-0.3	0.5	0.9	-0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.0	-1.0	-0.1	0.1	1.7	0.7	0.4	1.2
Falls in the last year	3.2	4.4	7.8	-1.7	2.3	2.6	1.2	2.8	1.1	2.2
Hair/balding pattern: Pattern 3	1.0	1.5	3.6	0.5	-0.5	-0.8	-1.9	-1.7	-1.2	-1.1
Number of live births	3.0	4.3	7.1	2.2	-2.2	-1.5	-2.7	-2.2	-0.6	-2.4
Forced expiratory volume in 1-second (FEV1)	4.5	15.1	42.1	-1.2	2.6	2.3	4.9	4.0	6.5	3.0
Pulse rate	0.3	0.5	1.4	-0.4	0.1	-1.2	-0.7	-1.1	0.2	-0.0
Happiness	0.3	0.3	1.0	-0.2	-1.0	0.6	0.1	0.1	-0.8	0.5
Noisy workplace	1.5	1.9	4.4	1.3	-0.3	-1.4	-1.6	-2.1	-0.0	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	7.4	-2.6	1.2	2.0	2.0	2.2	-0.5	2.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.7	0.1	0.0	0.8	-0.0	0.2	-0.4
Mouth/teeth dental problems: Dentures	1.9	3.2	7.7	0.9	-1.3	-1.2	-2.0	-1.6	-2.8	-1.9
Asthma	1.1	2.2	4.4	1.8	-2.1	-1.4	-1.9	-0.6	-0.4	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.4	-0.3	1.5	-0.1	1.0	0.6	1.0	0.5
Medication: Cholesterol lowering	0.5	0.7	1.7	1.3	-1.0	-0.5	0.6	-0.1	1.2	-0.8
Depression (self-reported)	0.2	0.3	0.8	0.4	-0.9	-0.6	-0.1	-0.3	0.4	-0.6
Medication: Lansoprazole	0.4	0.4	0.9	0.6	0.5	-0.9	-0.0	0.8	0.9	0.2
Prospective memory result	0.8	0.9	3.1	0.2	-0.9	-0.4	-1.0	-1.2	-1.7	-0.6
Lung cancer (father)	0.4	0.5	2.7	-0.1	-0.3	-0.6	-0.3	0.4	-1.6	0.0
Illnesses of mother	2.3	2.8	5.6	-2.0	0.1	1.9	1.1	2.3	0.2	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	5.2	16.5	45.0	-1.7	3.2	2.2	5.2	3.9	6.7	3.2
Pulse wave Arterial Stiffness index	2.1	2.5	4.8	-2.2	1.5	0.3	1.7	1.5	0.7	2.2
Impedance of arm (left)	3.5	16.3	37.7	-1.9	3.9	0.8	4.3	3.9	6.1	4.7
Arm fat mass (right)	1.0	4.0	15.7	-0.1	0.3	-1.4	4.0	1.7	2.5	0.9
Trunk predicted mass	0.8	4.6	11.6	-1.3	-0.9	2.5	3.4	2.5	1.5	1.6
Standing height	6.0	59.6	103.1	-4.8	3.4	6.1	10.2	8.7	9.8	8.4
Length of working week for main job	1.1	1.2	4.2	0.5	-1.2	2.0	-0.7	0.6	-1.3	-0.2
Exposure to tobacco smoke at home	0.5	0.6	1.5	-1.2	0.1	0.8	-0.0	-0.5	-1.2	0.6
Breastfed as a baby	2.4	3.0	4.2	1.8	-1.8	-1.3	-1.7	-2.0	-1.5	-1.8
Tense / ‘highly strung’	1.7	2.9	4.0	1.5	-2.0	-1.2	-1.9	-1.7	-1.7	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	6.6	2.6	-2.0	-1.2	-2.0	-1.9	0.6	-2.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.9	0.6	-1.0	-1.3	1.4	0.2	0.9	-0.8
Birth weight of first child	0.4	0.7	1.7	1.1	-1.3	-0.6	0.8	-0.2	-0.1	-1.0
Peak expiratory flow (PEF)	1.3	3.0	6.9	-1.1	1.7	1.2	2.0	2.6	1.3	1.6
Pulse wave reflection index	1.3	1.6	2.8	-1.7	0.9	0.1	1.7	1.1	-1.4	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	-1.3	0.2	0.9	1.0	0.5	0.3	1.4
Loud music exposure frequency	0.3	0.3	1.3	0.4	-1.1	0.2	-0.4	0.7	-0.0	-0.0
Qualifications: O levels/GCSEs or equivalent	3.8	6.0	11.5	-3.2	0.9	3.4	2.3	2.3	-0.5	3.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.9	-1.2	0.5	1.4	1.2	1.3	0.0	1.3
Blood clot in the leg (DVT)	2.1	2.7	6.1	2.5	-2.1	0.3	-1.4	-0.8	1.5	-1.7
Medication: Paracetamol	0.6	0.9	2.4	-0.2	0.7	1.1	1.5	1.1	1.1	0.3
Headache pain in last month	0.4	0.7	1.8	0.7	-1.1	-0.6	0.4	0.9	1.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	-0.2	0.9	0.4	-0.8	-0.6	-0.9	-0.1
Glaucoma (self-reported)	0.2	0.2	0.6	-0.2	-0.3	-0.5	0.3	-0.8	-0.5	-0.2
Gout (self-reported)	2.2	3.1	6.2	-1.4	1.0	2.2	1.8	2.5	0.6	1.9
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	6.4	-1.8	2.2	1.3	2.5	1.8	1.6	2.4
Medication: Amlodipine	0.6	0.8	1.8	0.3	-1.0	-1.3	0.7	-0.8	-0.5	-1.1
Medication: Ventolin 100micrograms inhaler	2.2	2.8	7.0	1.2	-0.4	-2.2	-1.5	-2.6	0.1	-1.9
Birth weight	0.5	1.2	2.6	0.5	-1.6	0.6	-1.4	-1.4	0.3	-1.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	4.1	1.1	0.0	0.3	-2.0	-1.9	-0.8	-1.3
High blood pressure (siblings)	0.3	0.4	2.4	-0.5	0.1	-1.6	0.2	-0.3	0.3	0.1
Forced vital capacity (FVC), Best measure	3.3	11.9	37.4	-1.1	2.5	2.8	3.3	3.6	6.1	2.6
Body fat percentage	2.7	10.8	29.5	-0.2	1.8	-1.9	5.4	2.6	5.3	2.2
Leg fat percentage (right)	2.0	7.2	20.6	0.9	0.9	-3.4	4.0	1.0	4.5	0.7
Arm fat-free mass (right)	0.8	4.3	12.2	-0.9	-0.3	2.2	3.5	2.4	2.1	1.4
Exposure to tobacco smoke outside home	1.0	1.3	3.3	-1.8	0.9	0.8	-0.3	1.0	-0.8	1.6
Comparative body size at age 10	0.4	1.2	3.4	0.8	-0.3	0.5	-1.8	-0.1	-1.7	-1.0
Number of full brothers	0.5	0.6	1.8	1.4	-0.1	-0.4	-0.7	-0.6	-0.3	-1.2
Worry too long after embarrassment	2.4	4.0	8.4	-2.0	1.6	0.6	2.2	2.9	0.6	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	3.5	1.6	-1.5	0.4	-1.9	-0.6	-0.4	-1.6
Wheeze or whistling in the chest in last year	2.7	4.9	10.4	3.2	-2.0	-2.8	-1.5	-1.9	0.3	-2.4
Number of children fathered	2.6	3.0	5.4	2.1	-1.1	-0.7	-2.2	-2.1	-0.2	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.2	1.0	-0.8	-0.2	-0.8	-0.8	-1.4	-1.5
Age at first live birth	1.3	2.3	5.6	-1.5	0.6	1.1	1.0	2.4	0.8	2.3
Pulse wave peak to peak time	0.9	1.1	2.8	1.7	-1.2	0.2	-0.9	-0.7	-0.0	-1.4
Health satisfaction	0.6	0.8	2.1	1.4	-0.9	-1.0	-0.4	-0.7	-0.0	-1.1
Shortness of breath walking on level ground	0.7	0.9	1.8	0.6	-0.9	1.3	0.2	1.3	1.1	0.1
Qualifications: College or University degree	0.2	0.7	1.2	0.1	1.1	0.9	0.9	0.7	1.1	0.7
Eye problems/disorders: None of the above	1.0	1.1	2.5	-0.6	1.6	1.1	0.9	1.3	0.7	1.0
Mouth/teeth dental problems: Loose teeth	1.1	1.4	3.5	0.4	0.3	-1.6	-1.2	-1.9	0.8	-0.9
Emphysema/chronic bronchitis	3.6	4.1	9.1	1.7	-3.0	-2.3	-2.2	-1.7	-0.3	-1.8
Medication for pain relief, constipation, heartburn	0.9	1.5	4.4	0.6	-1.6	-0.7	-2.1	-1.2	-0.9	-0.7
Neck or shoulder pain in last month	1.2	1.7	3.3	1.7	-1.8	-0.8	-1.0	-0.9	0.6	-1.7
Medication: Blood pressure	0.2	0.4	1.0	-0.5	0.4	-0.4	1.0	0.6	0.4	0.7
Angina (self-reported)	0.6	0.7	2.7	-0.5	1.5	0.3	-0.1	-0.2	1.6	0.0
Migraine (self-reported)	1.6	2.0	4.2	2.1	-1.8	-1.3	-0.8	-0.6	1.3	-1.5
Medication: Ibuprofen	0.6	0.7	2.5	0.7	0.9	-0.4	0.8	0.3	1.6	-0.1
Medication: Allopurinol	1.4	1.8	4.3	-0.8	0.3	2.1	1.3	1.8	1.1	1.3
Medication: Omeprazole	0.4	0.5	1.7	0.4	-1.1	0.0	1.3	-0.2	0.5	-0.2
Medication: Seretide 50 evohaler	1.1	1.2	2.5	0.9	-0.3	-1.5	-1.6	-1.4	-0.2	-1.0
Mean time to correctly identify matches	1.8	3.4	7.5	1.4	-1.0	-2.2	-2.7	-1.8	-1.1	-2.0
Heart disease (mother)	0.9	1.1	2.5	0.5	1.4	-0.6	-0.0	-1.5	1.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.2	-0.1	1.5	-0.5	-0.8	0.4	-1.8	-0.0
Whole body fat mass	2.6	10.8	32.5	-0.8	1.4	-0.9	5.7	3.1	4.9	2.5
Leg fat mass (right)	1.8	6.9	22.4	0.1	0.7	-1.7	4.7	2.0	4.1	1.4
Arm predicted mass (right)	0.9	4.4	12.7	-1.1	-0.2	2.1	3.6	2.3	2.2	1.5
Pulse rate, automated reading	2.5	8.1	12.8	2.2	-3.6	-3.5	-2.4	-3.0	-1.8	-2.9
Alcohol intake frequency.	1.7	3.9	6.8	2.6	-2.2	-1.6	-1.2	-2.1	1.2	-2.3
Comparative height size at age 10	5.7	31.6	45.4	-3.9	4.0	4.2	6.7	6.5	6.5	6.6
Number of full sisters	5.0	6.1	9.8	2.3	-1.9	-2.4	-3.0	-3.1	-0.7	-3.0
Suffer from ‘nerves’	0.3	0.5	1.0	-0.5	0.5	0.4	0.8	1.0	0.6	0.9
Overall health rating	0.5	1.2	3.3	1.2	-1.8	-1.4	0.0	-0.1	0.8	-0.9
Chest pain or discomfort	0.9	1.2	3.2	1.2	-1.2	-1.0	-0.1	-0.9	1.8	-0.8
Had major operations	0.2	0.2	0.7	-0.2	-0.3	0.1	-0.6	0.2	-0.8	0.3
Age at last live birth	0.3	0.4	1.0	0.7	-0.6	-1.0	-0.2	-0.2	-0.9	-0.6
Family relationship satisfaction	2.2	2.8	5.6	1.7	-0.8	-1.2	-1.8	-2.3	-0.3	-2.4
Leg pain on walking	1.1	1.3	3.1	1.8	-0.2	-0.9	-0.4	-1.2	1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	-0.0	-0.5	1.0	0.4	1.1	-0.0	0.2
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.5	-1.0	1.4	-0.0	0.3	1.9	1.3	1.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.4	0.6	-1.5	-0.3	-1.4	-1.0	-0.6	-0.7
Medication: Aspirin	0.2	0.2	0.5	0.1	0.6	0.2	-0.4	-0.7	0.7	-0.4
Supplements: Vitamin C	0.3	0.4	1.2	-0.1	-0.5	0.6	-0.8	-0.1	-1.1	-0.0
Knee pain experienced in last month	0.9	1.5	4.5	1.4	-2.1	-0.5	0.8	-0.7	1.0	-1.1
Hypertension (Self-reported)	0.4	1.2	4.4	-1.1	0.0	-0.9	2.1	0.9	-0.5	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	1.2	-0.6	-0.3	0.5	-0.2	0.8	-0.8
Illnesses of father: Heart disease	0.3	0.4	1.5	1.2	0.1	-0.4	-0.3	-0.4	0.1	-1.0
Illnesses of siblings: Diabetes	1.0	1.2	3.4	-0.3	1.4	0.1	0.4	1.5	1.8	0.9
Smoking status: Previous	0.2	0.3	0.8	0.4	-0.2	-0.8	0.3	0.9	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	8.6	17.9	29.8	-4.2	2.5	3.3	4.7	4.8	4.1	5.5
Whole body fat-free mass	0.8	4.8	11.8	-1.5	-0.9	2.7	3.4	2.6	1.3	1.7
Leg fat-free mass (right)	0.8	4.1	9.4	-1.5	-1.0	3.1	2.8	2.4	0.7	1.4
Arm fat percentage (left)	0.9	3.6	11.4	0.2	0.7	-2.0	3.4	1.4	2.6	0.8
Average weekly red wine intake	0.4	0.7	2.7	-0.2	-0.9	-0.7	1.6	0.3	0.5	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.1	-0.3	0.8	0.7	0.7	0.6	0.1
Mood swings	0.4	0.8	3.0	1.7	-0.7	-0.3	-0.7	-0.4	0.1	-1.1
Loneliness, isolation	0.2	0.3	0.8	0.9	-0.8	0.4	-0.3	0.2	0.1	-0.3
Long-standing illness, disability or infirmity	0.6	0.8	2.8	1.1	-1.7	-1.2	-0.1	-0.2	0.2	-0.7
Ever had bowel cancer screening	0.5	0.6	1.8	0.3	1.0	-0.8	-1.3	-0.1	-0.7	-0.3
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.8	0.1	0.3	0.8	0.9	0.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.8	0.7	-1.1	-0.3	-2.0	-0.6	-1.2	-0.9
Friendships satisfaction	0.1	0.1	0.6	0.1	-0.7	-0.2	-0.6	-0.1	-0.1	0.3
Qualifications: nursing, teaching	0.9	1.4	4.3	-0.6	0.5	0.9	0.3	2.1	0.7	1.8
Commuting to job workplace: Walk	1.5	1.6	4.7	0.4	-1.1	-0.7	-0.7	-2.2	-1.2	-1.6
Eye problems/disorders: Cataract	0.4	0.5	1.0	-0.9	-0.2	0.1	0.5	0.6	1.0	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.4	-0.2	-0.0	-0.8	-0.3	-0.3	-1.9	-0.6
Medication for cholesterol	0.5	0.8	4.0	0.1	1.2	2.0	-0.1	0.4	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.2	1.8	-0.9	0.2	-1.4	-1.2	-0.7	-1.3
Back pain experienced in last month	1.3	1.9	3.5	-0.3	0.6	1.8	1.4	1.7	1.9	1.0
Mineral and other dietary supplements	1.3	1.8	3.3	1.5	-1.0	-1.8	-1.1	-1.0	-1.3	-1.3
Breast cancer (self-reported)	0.4	0.5	1.0	-1.0	-0.1	0.8	0.6	0.4	-1.0	0.6
Asthma (self-reported)	1.2	2.5	5.7	2.0	-2.4	-1.3	-1.9	-0.6	-0.5	-1.4
Osteoporosis (self-reported)	0.4	0.5	3.0	-0.5	1.7	-0.2	-0.2	-0.1	-0.5	0.3
Osteoarthritis (self-reported)	1.3	1.6	4.4	0.4	0.7	1.5	1.4	2.1	1.4	0.2
Medication: Aspirin	0.1	0.1	0.4	-0.3	0.6	0.6	-0.1	-0.4	0.3	0.0
Medication: Gliclazide	0.2	0.2	1.1	0.5	-0.2	-0.2	-1.0	-0.1	0.5	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	-0.9	-0.4	1.0	-0.6	0.2	-0.2	0.5
Smoking status: Current	0.4	0.6	1.8	0.7	-0.6	0.0	-0.7	-1.3	0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.1	-0.1	0.4	-0.4	1.7	0.2	1.4	-0.1
Whole body water mass	0.8	4.6	11.3	-1.4	-0.8	2.6	3.4	2.6	1.3	1.6
Leg predicted mass (right)	0.7	4.0	9.3	-1.5	-1.0	3.1	2.7	2.4	0.7	1.4
Arm fat mass (left)	1.1	4.5	17.3	-0.3	0.6	-1.1	4.2	1.9	2.8	1.2
Number of self-reported non-cancer illnesses	0.8	1.3	3.3	0.8	-1.8	0.6	1.1	1.8	0.7	-0.0
Average weekly champagne plus white wine intake	2.1	2.8	4.3	-2.1	1.7	1.9	1.3	1.6	-1.1	1.9
Miserableness	0.2	0.3	1.0	0.7	-0.0	0.3	-0.2	0.5	1.0	-0.1
Guilty feelings	0.4	0.7	1.7	-0.2	0.5	0.4	0.9	1.3	0.8	1.0
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.3	-0.2	0.2	0.4	0.3	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.4	-0.4	-0.3	0.1	-0.5	-0.0	0.1
Hearing aid user	0.5	0.6	2.1	0.4	-0.8	-0.5	1.4	0.9	0.1	-0.0
Mother’s age at death	0.3	0.4	0.9	0.4	0.2	0.3	0.0	-0.9	0.9	-0.7
Financial situation satisfaction	0.5	0.6	1.9	0.1	-1.2	1.0	-1.4	0.0	-0.1	0.3
Tinnitus: Yes, now most or all of the time	2.4	2.8	8.3	0.6	-1.5	-2.1	-0.2	-2.9	-1.3	-1.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.3	-0.0	0.2	-0.4	-0.3	-0.4	-0.4
Eye problems/disorders: Glaucoma	0.5	0.5	2.2	0.0	-0.7	-0.6	-0.2	-0.7	-1.5	-0.5
Medication: Blood pressure	0.7	1.4	4.2	-2.0	-0.4	-0.8	1.4	0.5	-1.1	1.2
Pain type(s) experienced in last month: Hip pain	1.6	2.0	8.1	-0.6	0.7	0.8	2.8	1.2	1.5	0.9
Supplements: Fish oil (including cod liver oil)	1.6	2.0	3.6	-1.8	1.5	1.9	1.1	0.9	1.2	1.3
High cholesterol (Self-reported)	0.3	0.6	1.6	0.9	-1.3	-0.2	-0.7	-0.5	0.0	-0.8
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.1	-0.5	-0.6	0.0	-0.7	0.5	-0.4
Medication: Paracetamol	0.6	1.0	2.6	0.1	0.7	1.3	0.9	1.0	1.6	0.3
Medication: Lisinopril	0.7	1.0	3.6	-0.3	0.2	-0.6	1.3	0.9	1.9	0.4
Medication: Atorvastatin	1.4	1.7	3.4	1.5	-1.9	-1.0	-1.3	-1.2	0.3	-1.5
Illnesses of father: High blood pressure	1.8	2.3	4.9	-1.2	2.2	0.1	1.8	1.8	0.1	1.8
Alcohol drinker status: Never	0.2	0.3	0.8	0.8	0.1	0.2	-0.9	-0.4	0.1	-0.4
Ever smoked	0.1	0.2	0.5	-0.3	-0.1	0.7	-0.2	0.5	-0.1	0.6
Basal metabolic rate	1.2	6.5	18.9	-1.6	-0.3	2.3	4.4	3.0	2.3	2.1
Leg fat percentage (left)	1.7	6.2	18.7	1.0	0.9	-2.9	3.7	0.9	4.3	0.4
Arm fat-free mass (left)	0.8	4.0	13.1	-0.9	-0.3	1.8	3.6	2.3	2.0	1.2
Number of operations (self-reported)	0.1	0.1	0.2	-0.0	0.5	0.1	0.2	-0.0	0.5	0.5
Average weekly beer plus cider intake	0.7	1.0	1.7	-1.1	1.0	0.9	0.9	1.3	-0.5	1.1
Irritability	1.7	3.0	7.0	-1.9	0.7	2.0	1.3	1.7	0.8	2.7
Risk taking	1.0	1.5	2.8	1.7	-1.4	0.2	-1.3	-1.4	-0.0	-1.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.0	0.1	-0.4	1.4	-0.1	1.1	0.1	0.2
Fractured/broken bones in last 5 years	0.7	0.9	3.7	1.1	0.5	0.2	0.8	-0.4	1.9	-0.4
Age started oral contraceptive pill	2.4	3.0	6.2	0.3	-1.2	-1.4	-2.1	-2.0	-2.5	-1.6
Diastolic blood pressure, automated reading	2.1	6.6	14.8	-3.6	2.0	0.2	3.9	2.2	-0.5	3.1
Ever depressed for a whole week	2.6	3.1	6.3	2.5	-1.9	-1.6	-1.2	-2.2	-0.2	-1.8
Unable to work because of sickness or disability	2.2	2.9	8.1	2.9	-1.6	-0.5	-1.8	-1.1	0.2	-2.1
Commuting to job workplace: Cycle	0.9	1.0	6.0	0.7	-0.3	2.4	-0.3	0.3	-0.6	-0.4
Myopia	0.5	0.7	1.8	0.9	0.0	-1.3	0.2	-1.0	-0.3	-1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.2	1.9	-0.3	-0.5	-2.5	-1.4	0.2	-1.8
Cholesterol lowering medication	0.3	0.4	0.8	-0.2	-0.9	-0.8	0.0	-0.9	-0.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.2	-0.5	0.1	0.8	1.8	0.8	0.8	0.9
Pain experienced in last month	0.6	1.0	5.0	-0.9	0.1	-0.2	-0.7	-0.5	-2.2	0.2
Supplements: Calcium	0.7	0.7	1.3	1.1	-0.9	-0.1	-0.6	-0.8	1.0	-1.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.4	1.5	-0.6	-0.1	-0.5	0.1	1.5	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.2	-0.5	0.4	1.0	0.7	0.9	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	2.4	3.0	6.8	2.6	-2.3	0.5	-1.4	-0.8	1.8	-1.7
Heart disease (siblings)	0.1	0.2	0.6	0.2	0.8	0.0	-0.1	-0.1	0.4	-0.5
Alcohol drinker status: Previous	1.8	2.1	4.0	2.0	-1.6	-1.5	-0.1	-0.9	1.9	-1.1
Pack years of smoking	1.0	1.5	3.1	-1.3	1.8	0.6	1.2	0.2	1.7	1.1
Impedance of whole body	4.5	23.0	58.1	-2.0	5.1	0.2	5.3	4.2	7.6	5.3
Leg fat mass (left)	1.7	6.6	21.5	0.1	0.7	-1.4	4.6	2.0	4.1	1.3
Arm predicted mass (left)	0.7	3.6	12.3	-0.7	-0.8	1.6	3.5	2.1	1.7	1.1