Best TWAS P=9.8e-21 · Best GWAS P=3.02e-27 conditioned to 1.9e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | UBN1 | 0.18 | 0.15 | lasso | 4 | 0.14 | 6.8e-08 | 6.7 | -6.1 | 1.1e-09 | -0.04 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | UBN1 | 0.20 | 0.06 | lasso | 7 | 0.07 | 4.8e-06 | 5.6 | -5.4 | 5.9e-08 | -0.02 | 0.09 | 0.91 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | ZNF500 | 0.27 | 0.13 | enet | 13 | 0.12 | 4.4e-04 | 2.9 | 5.5 | 3.1e-08 | 0.00 | 0.22 | 0.44 | TRUE |
| 4 | GTEx | Brain Cortex | ZNF500 | 0.18 | 0.02 | enet | 8 | 0.04 | 2.5e-02 | -4.6 | 5.5 | 5.1e-08 | 0.05 | 0.08 | 0.14 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-95P2.1 | 0.13 | 0.11 | lasso | 3 | 0.12 | 2.0e-09 | 5.0 | -5.4 | 7.4e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | UBN1 | 0.12 | 0.06 | lasso | 3 | 0.08 | 5.1e-06 | 6.2 | -6.3 | 2.3e-10 | -0.05 | 0.08 | 0.91 | FALSE |
| 7 | GTEx | Esophagus Muscularis | UBN1 | 0.18 | 0.19 | lasso | 4 | 0.19 | 9.1e-12 | 6.7 | -6.5 | 8.6e-11 | -0.04 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Muscle Skeletal | ZNF500 | 0.06 | 0.00 | enet | 15 | 0.00 | 2.8e-01 | 2.9 | 5.7 | 9.7e-09 | 0.05 | 0.06 | 0.16 | FALSE |
| 9 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 6.5 | -6.6 | 5.2e-11 | -0.04 | 0.05 | 0.94 | TRUE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | UBN1 | 0.22 | 0.16 | lasso | 4 | 0.14 | 2.5e-08 | 6.0 | -5.7 | 1.2e-08 | -0.04 | 0.07 | 0.93 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | PPL | 0.10 | 0.04 | lasso | 6 | 0.02 | 5.7e-03 | 6.2 | 6.0 | 1.8e-09 | 0.05 | 0.08 | 0.73 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | UBN1 | 0.16 | 0.15 | lasso | 5 | 0.17 | 9.5e-14 | 6.7 | -6.1 | 8.6e-10 | -0.05 | 0.05 | 0.95 | FALSE |
| 13 | GTEx | Testis | ROGDI | 0.17 | 0.09 | enet | 10 | 0.10 | 2.1e-05 | 5.5 | -5.6 | 2.5e-08 | 0.01 | 0.18 | 0.58 | FALSE |
| 14 | GTEx | Thyroid | RP11-95P2.1 | 0.15 | 0.10 | lasso | 5 | 0.10 | 3.9e-08 | 5.1 | -5.5 | 3.2e-08 | 0.03 | 0.94 | 0.00 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | ROGDI | 0.26 | 0.30 | enet | 27 | 0.30 | 5.2e-39 | -4.6 | -5.2 | 2.0e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | SEPT12 | 0.40 | 0.47 | enet | 29 | 0.48 | 7.1e-71 | -4.5 | 5.2 | 2.1e-07 | 0.05 | 1.00 | 0.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -10.5 | -9.3 | 9.8e-21 | 0.86 | 0.00 | 1.00 | TRUE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | UBN1 | 0.05 | 0.04 | enet | 7 | 0.05 | 4.2e-04 | -5.9 | 5.2 | 2.5e-07 | 0.06 | 0.02 | 0.76 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ROGDI | 0.03 | 0.04 | lasso | 3 | 0.03 | 1.6e-04 | 5.6 | -5.6 | 2.7e-08 | 0.01 | 0.02 | 0.95 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ROGDI | 0.05 | 0.02 | lasso | 2 | 0.03 | 6.0e-04 | -4.5 | -5.3 | 1.3e-07 | -0.05 | 0.05 | 0.10 | FALSE |