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chr16:3,301,360-5,706,977

Best TWAS P=9.8e-21 · Best GWAS P=3.02e-27 conditioned to 1.9e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	ROSMAP	Brain Pre-frontal Cortex	RP11-462G12.1	0.11	0.07	enet	18	0.06	1.1e-08	-10.5	-9.3	9.8e-21	0.86	0.00	1.00	TRUE
9	GTEx	Nerve Tibial	UBN1	0.14	0.12	lasso	4	0.11	5.6e-08	6.5	-6.6	5.2e-11	-0.04	0.05	0.94	TRUE
3	GTEx	Brain Cerebellar Hemisphere	ZNF500	0.27	0.13	enet	13	0.12	4.4e-04	2.9	5.5	3.1e-08	0.00	0.22	0.44	TRUE
14	GTEx	Thyroid	RP11-95P2.1	0.15	0.10	lasso	5	0.10	3.9e-08	5.1	-5.5	3.2e-08	0.03	0.94	0.00	TRUE
7	GTEx	Esophagus Muscularis	UBN1	0.18	0.19	lasso	4	0.19	9.1e-12	6.7	-6.5	8.6e-11	-0.04	0.04	0.96	FALSE
6	GTEx	Esophagus Mucosa	UBN1	0.12	0.06	lasso	3	0.08	5.1e-06	6.2	-6.3	2.3e-10	-0.05	0.08	0.91	FALSE
12	GTEx	Skin Sun Exposed Lower leg	UBN1	0.16	0.15	lasso	5	0.17	9.5e-14	6.7	-6.1	8.6e-10	-0.05	0.05	0.95	FALSE
1	GTEx	Artery Aorta	UBN1	0.18	0.15	lasso	4	0.14	6.8e-08	6.7	-6.1	1.1e-09	-0.04	0.04	0.96	FALSE
11	GTEx	Skin Sun Exposed Lower leg	PPL	0.10	0.04	lasso	6	0.02	5.7e-03	6.2	6.0	1.8e-09	0.05	0.08	0.73	FALSE
8	GTEx	Muscle Skeletal	ZNF500	0.06	0.00	enet	15	0.00	2.8e-01	2.9	5.7	9.7e-09	0.05	0.06	0.16	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	UBN1	0.22	0.16	lasso	4	0.14	2.5e-08	6.0	-5.7	1.2e-08	-0.04	0.07	0.93	FALSE
13	GTEx	Testis	ROGDI	0.17	0.09	enet	10	0.10	2.1e-05	5.5	-5.6	2.5e-08	0.01	0.18	0.58	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ROGDI	0.03	0.04	lasso	3	0.03	1.6e-04	5.6	-5.6	2.7e-08	0.01	0.02	0.95	FALSE
4	GTEx	Brain Cortex	ZNF500	0.18	0.02	enet	8	0.04	2.5e-02	-4.6	5.5	5.1e-08	0.05	0.08	0.14	FALSE
2	GTEx	Artery Tibial	UBN1	0.20	0.06	lasso	7	0.07	4.8e-06	5.6	-5.4	5.9e-08	-0.02	0.09	0.91	FALSE
5	GTEx	Cells Transformed fibroblasts	RP11-95P2.1	0.13	0.11	lasso	3	0.12	2.0e-09	5.0	-5.4	7.4e-08	0.05	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	ROGDI	0.05	0.02	lasso	2	0.03	6.0e-04	-4.5	-5.3	1.3e-07	-0.05	0.05	0.10	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	ROGDI	0.26	0.30	enet	27	0.30	5.2e-39	-4.6	-5.2	2.0e-07	-0.03	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	SEPT12	0.40	0.47	enet	29	0.48	7.1e-71	-4.5	5.2	2.1e-07	0.05	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	UBN1	0.05	0.04	enet	7	0.05	4.2e-04	-5.9	5.2	2.5e-07	0.06	0.02	0.76	FALSE