[Hub]/) : Traits : Whole body fat mass :

chr16:3,301,360-5,706,977

Best TWAS P=9.8e-21 · Best GWAS P=3.02e-27 conditioned to 1.9e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta UBN1 0.18 0.15 lasso 4 0.14 6.8e-08 6.7 -6.1 1.1e-09 -0.04 0.04 0.96 FALSE
2 GTEx Artery Tibial UBN1 0.20 0.06 lasso 7 0.07 4.8e-06 5.6 -5.4 5.9e-08 -0.02 0.09 0.91 FALSE
3 GTEx Brain Cerebellar Hemisphere ZNF500 0.27 0.13 enet 13 0.12 4.4e-04 2.9 5.5 3.1e-08 0.00 0.22 0.44 TRUE
4 GTEx Brain Cortex ZNF500 0.18 0.02 enet 8 0.04 2.5e-02 -4.6 5.5 5.1e-08 0.05 0.08 0.14 FALSE
5 GTEx Cells Transformed fibroblasts RP11-95P2.1 0.13 0.11 lasso 3 0.12 2.0e-09 5.0 -5.4 7.4e-08 0.05 1.00 0.00 FALSE
6 GTEx Esophagus Mucosa UBN1 0.12 0.06 lasso 3 0.08 5.1e-06 6.2 -6.3 2.3e-10 -0.05 0.08 0.91 FALSE
7 GTEx Esophagus Muscularis UBN1 0.18 0.19 lasso 4 0.19 9.1e-12 6.7 -6.5 8.6e-11 -0.04 0.04 0.96 FALSE
8 GTEx Muscle Skeletal ZNF500 0.06 0.00 enet 15 0.00 2.8e-01 2.9 5.7 9.7e-09 0.05 0.06 0.16 FALSE
9 GTEx Nerve Tibial UBN1 0.14 0.12 lasso 4 0.11 5.6e-08 6.5 -6.6 5.2e-11 -0.04 0.05 0.94 TRUE
10 GTEx Skin Not Sun Exposed Suprapubic UBN1 0.22 0.16 lasso 4 0.14 2.5e-08 6.0 -5.7 1.2e-08 -0.04 0.07 0.93 FALSE
11 GTEx Skin Sun Exposed Lower leg PPL 0.10 0.04 lasso 6 0.02 5.7e-03 6.2 6.0 1.8e-09 0.05 0.08 0.73 FALSE
12 GTEx Skin Sun Exposed Lower leg UBN1 0.16 0.15 lasso 5 0.17 9.5e-14 6.7 -6.1 8.6e-10 -0.05 0.05 0.95 FALSE
13 GTEx Testis ROGDI 0.17 0.09 enet 10 0.10 2.1e-05 5.5 -5.6 2.5e-08 0.01 0.18 0.58 FALSE
14 GTEx Thyroid RP11-95P2.1 0.15 0.10 lasso 5 0.10 3.9e-08 5.1 -5.5 3.2e-08 0.03 0.94 0.00 TRUE
15 ROSMAP Brain Pre-frontal Cortex ROGDI 0.26 0.30 enet 27 0.30 5.2e-39 -4.6 -5.2 2.0e-07 -0.03 1.00 0.00 FALSE
16 ROSMAP Brain Pre-frontal Cortex SEPT12 0.40 0.47 enet 29 0.48 7.1e-71 -4.5 5.2 2.1e-07 0.05 1.00 0.00 FALSE
17 ROSMAP Brain Pre-frontal Cortex RP11-462G12.1 0.11 0.07 enet 18 0.06 1.1e-08 -10.5 -9.3 9.8e-21 0.86 0.00 1.00 TRUE
18 The Cancer Genome Atlas Colon Adenocarcinoma UBN1 0.05 0.04 enet 7 0.05 4.2e-04 -5.9 5.2 2.5e-07 0.06 0.02 0.76 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ROGDI 0.03 0.04 lasso 3 0.03 1.6e-04 5.6 -5.6 2.7e-08 0.01 0.02 0.95 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma ROGDI 0.05 0.02 lasso 2 0.03 6.0e-04 -4.5 -5.3 1.3e-07 -0.05 0.05 0.10 FALSE