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chr16:86,671-3,010,510

Best TWAS P=1.07e-11 · Best GWAS P=4.36e-13 conditioned to 0.952

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASKIN1	0.02	0.00	blup	38	0.01	4.5e-02	5.0	-6.8	1.1e-11	0.46	0.03	0.04	TRUE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	AXIN1	0.03	0.01	blup	88	0.01	7.7e-03	-5.9	6.6	3.1e-11	-0.03	0.01	0.76	TRUE
25	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A3R2	0.06	0.03	lasso	5	0.03	3.7e-04	-5.0	6.5	9.6e-11	-0.60	0.12	0.53	TRUE
3	GTEx	Brain Cerebellar Hemisphere	CCDC78	0.21	0.12	enet	12	0.12	6.2e-04	-3.6	-5.2	2.7e-07	0.01	0.15	0.36	TRUE
22	The Cancer Genome Atlas	Thyroid Carcinoma	CASKIN1	0.06	0.02	blup	38	0.04	1.5e-04	-7.2	-6.5	1.0e-10	0.81	0.00	0.98	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC100134368	0.05	0.00	blup	48	0.04	2.5e-05	-4.5	-6.4	1.4e-10	0.04	0.01	0.88	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100134368	0.03	0.00	enet	5	0.01	2.8e-02	-3.5	-6.2	6.9e-10	0.03	0.01	0.62	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	MLST8	0.22	0.18	lasso	6	0.18	7.1e-23	5.3	6.1	9.7e-10	-0.49	0.99	0.01	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	PDIA2	0.15	0.07	lasso	8	0.10	5.2e-13	-4.9	-6.0	2.3e-09	0.04	0.06	0.94	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	SLC9A3R2	0.16	0.11	lasso	6	0.12	6.3e-15	-6.1	6.0	2.5e-09	-0.62	0.80	0.20	FALSE
6	GTEx	Nerve Tibial	ARHGDIG	0.13	0.07	lasso	2	0.07	8.0e-06	-6.0	5.9	2.9e-09	-0.07	0.02	0.94	FALSE
5	GTEx	Nerve Tibial	PDIA2	0.12	0.01	enet	13	0.06	4.4e-05	-5.6	5.9	4.1e-09	-0.05	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf79	0.05	0.01	lasso	4	0.02	1.5e-03	5.0	-5.8	5.9e-09	0.24	0.01	0.94	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	MLST8	0.09	0.07	enet	8	0.09	9.9e-09	5.7	5.8	7.7e-09	-0.30	0.00	1.00	FALSE
10	METSIM	Adipose	PKD1	0.06	0.02	bslmm	370	0.03	9.5e-06	-6.6	5.8	8.9e-09	-0.78	0.00	0.99	FALSE
8	GTEx	Testis	AXIN1	0.36	0.29	lasso	3	0.28	4.3e-13	-6.0	-5.7	1.4e-08	0.04	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SLC9A3R2	0.15	0.09	enet	7	0.10	7.8e-12	-5.0	5.6	1.9e-08	-0.59	0.93	0.07	FALSE
15	YFS	Blood	MLST8	0.12	0.06	bslmm	326	0.06	4.3e-20	-4.0	5.6	2.8e-08	-0.38	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	LOC100134368	0.06	0.05	blup	47	0.07	3.9e-07	2.6	-5.5	4.6e-08	0.05	0.22	0.70	FALSE
7	GTEx	Skin Sun Exposed Lower leg	RNPS1	0.10	0.01	lasso	6	0.04	6.3e-04	3.5	-5.4	8.1e-08	0.32	0.07	0.81	FALSE
2	GTEx	Artery Aorta	TSC2	0.08	0.02	enet	7	0.03	5.0e-03	-5.3	5.3	9.4e-08	-0.52	0.14	0.33	FALSE
9	GTEx	Whole Blood	NME4	0.12	0.03	lasso	5	0.04	3.0e-04	2.6	5.3	9.6e-08	-0.07	0.03	0.94	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	MLST8	0.07	0.07	enet	6	0.08	1.2e-09	-4.0	5.3	1.3e-07	-0.25	0.01	0.99	FALSE
4	GTEx	Nerve Tibial	AXIN1	0.11	0.09	lasso	2	0.06	3.9e-05	-6.0	5.2	2.0e-07	-0.04	0.02	0.98	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	BRICD5	0.19	0.05	enet	36	0.06	4.5e-08	5.7	-5.2	2.1e-07	0.23	0.97	0.03	FALSE