Best TWAS P=1.07e-11 · Best GWAS P=4.36e-13 conditioned to 0.952
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -5.0 | 5.6 | 1.9e-08 | -0.59 | 0.93 | 0.07 | FALSE |
| 2 | GTEx | Artery Aorta | TSC2 | 0.08 | 0.02 | enet | 7 | 0.03 | 5.0e-03 | -5.3 | 5.3 | 9.4e-08 | -0.52 | 0.14 | 0.33 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | CCDC78 | 0.21 | 0.12 | enet | 12 | 0.12 | 6.2e-04 | -3.6 | -5.2 | 2.7e-07 | 0.01 | 0.15 | 0.36 | TRUE |
| 4 | GTEx | Nerve Tibial | AXIN1 | 0.11 | 0.09 | lasso | 2 | 0.06 | 3.9e-05 | -6.0 | 5.2 | 2.0e-07 | -0.04 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -5.6 | 5.9 | 4.1e-09 | -0.05 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -6.0 | 5.9 | 2.9e-09 | -0.07 | 0.02 | 0.94 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RNPS1 | 0.10 | 0.01 | lasso | 6 | 0.04 | 6.3e-04 | 3.5 | -5.4 | 8.1e-08 | 0.32 | 0.07 | 0.81 | FALSE |
| 8 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -6.0 | -5.7 | 1.4e-08 | 0.04 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 2.6 | 5.3 | 9.6e-08 | -0.07 | 0.03 | 0.94 | FALSE |
| 10 | METSIM | Adipose | PKD1 | 0.06 | 0.02 | bslmm | 370 | 0.03 | 9.5e-06 | -6.6 | 5.8 | 8.9e-09 | -0.78 | 0.00 | 0.99 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.1 | 6.0 | 2.5e-09 | -0.62 | 0.80 | 0.20 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | MLST8 | 0.22 | 0.18 | lasso | 6 | 0.18 | 7.1e-23 | 5.3 | 6.1 | 9.7e-10 | -0.49 | 0.99 | 0.01 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | BRICD5 | 0.19 | 0.05 | enet | 36 | 0.06 | 4.5e-08 | 5.7 | -5.2 | 2.1e-07 | 0.23 | 0.97 | 0.03 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -4.9 | -6.0 | 2.3e-09 | 0.04 | 0.06 | 0.94 | FALSE |
| 15 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | -4.0 | 5.6 | 2.8e-08 | -0.38 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.9 | 6.6 | 3.1e-11 | -0.03 | 0.01 | 0.76 | TRUE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CASKIN1 | 0.02 | 0.00 | blup | 38 | 0.01 | 4.5e-02 | 5.0 | -6.8 | 1.1e-11 | 0.46 | 0.03 | 0.04 | TRUE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -3.5 | -6.2 | 6.9e-10 | 0.03 | 0.01 | 0.62 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MLST8 | 0.07 | 0.07 | enet | 6 | 0.08 | 1.2e-09 | -4.0 | 5.3 | 1.3e-07 | -0.25 | 0.01 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf79 | 0.05 | 0.01 | lasso | 4 | 0.02 | 1.5e-03 | 5.0 | -5.8 | 5.9e-09 | 0.24 | 0.01 | 0.94 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.5 | -6.4 | 1.4e-10 | 0.04 | 0.01 | 0.88 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | CASKIN1 | 0.06 | 0.02 | blup | 38 | 0.04 | 1.5e-04 | -7.2 | -6.5 | 1.0e-10 | 0.81 | 0.00 | 0.98 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 2.6 | -5.5 | 4.6e-08 | 0.05 | 0.22 | 0.70 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | MLST8 | 0.09 | 0.07 | enet | 8 | 0.09 | 9.9e-09 | 5.7 | 5.8 | 7.7e-09 | -0.30 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -5.0 | 6.5 | 9.6e-11 | -0.60 | 0.12 | 0.53 | TRUE |