Best TWAS P=2.06e-13 · Best GWAS P=2.67e-13 conditioned to 0.152
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C17orf65 | 0.07 | 0.06 | enet | 15 | 0.07 | 4.5e-09 | 6.7 | -5.8 | 6.1e-09 | -0.84 | 0.18 | 0.82 | FALSE |
2 | GTEx | Adipose Subcutaneous | ASB16-AS1 | 0.12 | 0.05 | enet | 16 | 0.05 | 3.7e-05 | 6.7 | -5.9 | 3.6e-09 | -0.75 | 0.07 | 0.82 | FALSE |
3 | GTEx | Adipose Visceral Omentum | ASB16-AS1 | 0.14 | 0.12 | lasso | 5 | 0.10 | 9.8e-06 | 6.2 | -6.3 | 3.6e-10 | -0.84 | 0.33 | 0.63 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | ASB16-AS1 | 0.08 | 0.04 | lasso | 2 | 0.06 | 7.9e-03 | 6.2 | -6.3 | 3.0e-10 | -0.85 | 0.05 | 0.53 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | ASB16 | 0.14 | 0.14 | lasso | 3 | 0.12 | 2.0e-09 | 6.7 | -6.7 | 2.0e-11 | -0.89 | 0.11 | 0.89 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | FZD2 | 0.11 | 0.00 | enet | 21 | 0.04 | 1.0e-03 | 2.0 | 5.6 | 2.1e-08 | 0.48 | 0.07 | 0.42 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | ASB16-AS1 | 0.17 | 0.17 | lasso | 4 | 0.16 | 2.3e-12 | 6.7 | -6.5 | 7.9e-11 | -0.83 | 0.11 | 0.89 | FALSE |
8 | GTEx | Esophagus Mucosa | ASB16 | 0.10 | 0.10 | lasso | 4 | 0.08 | 8.2e-06 | 6.7 | -6.7 | 2.0e-11 | -0.89 | 0.07 | 0.92 | FALSE |
9 | GTEx | Esophagus Mucosa | ASB16-AS1 | 0.11 | 0.08 | enet | 16 | 0.07 | 3.7e-05 | 4.9 | -5.7 | 1.2e-08 | -0.78 | 0.17 | 0.82 | FALSE |
10 | GTEx | Heart Left Ventricle | RP5-882C2.2 | 0.14 | 0.08 | lasso | 5 | 0.10 | 8.1e-06 | 6.3 | -6.6 | 3.5e-11 | -0.83 | 0.04 | 0.94 | FALSE |
11 | GTEx | Lung | ASB16 | 0.09 | 0.09 | enet | 15 | 0.07 | 3.4e-06 | 6.7 | -5.9 | 4.7e-09 | -0.81 | 0.05 | 0.95 | FALSE |
12 | GTEx | Lung | ASB16-AS1 | 0.15 | 0.12 | enet | 19 | 0.12 | 1.5e-09 | 6.7 | -5.5 | 3.0e-08 | -0.79 | 0.08 | 0.92 | FALSE |
13 | GTEx | Muscle Skeletal | ASB16 | 0.07 | 0.06 | lasso | 3 | 0.06 | 2.9e-06 | 5.3 | 5.8 | 5.8e-09 | 0.80 | 0.12 | 0.88 | FALSE |
14 | GTEx | Nerve Tibial | ASB16 | 0.12 | 0.07 | lasso | 5 | 0.07 | 7.5e-06 | 6.7 | -6.6 | 5.4e-11 | -0.87 | 0.10 | 0.90 | FALSE |
15 | GTEx | Nerve Tibial | ASB16-AS1 | 0.17 | 0.15 | lasso | 5 | 0.16 | 1.4e-11 | 6.7 | -6.3 | 3.9e-10 | -0.85 | 0.13 | 0.87 | FALSE |
16 | GTEx | Pituitary | ASB16-AS1 | 0.19 | 0.17 | lasso | 4 | 0.22 | 3.8e-06 | 4.0 | -5.8 | 5.5e-09 | -0.79 | 0.12 | 0.72 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | ASB16 | 0.11 | 0.03 | enet | 9 | 0.02 | 4.3e-03 | 6.4 | -5.2 | 1.7e-07 | -0.74 | 0.16 | 0.62 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | ASB16-AS1 | 0.13 | 0.09 | lasso | 5 | 0.07 | 2.7e-06 | 6.4 | -6.3 | 2.4e-10 | -0.87 | 0.17 | 0.83 | FALSE |
19 | GTEx | Testis | ASB16-AS1 | 0.35 | 0.25 | lasso | 5 | 0.23 | 1.0e-10 | 6.7 | -6.8 | 1.2e-11 | -0.90 | 0.06 | 0.94 | FALSE |
20 | GTEx | Thyroid | RP5-882C2.2 | 0.10 | 0.07 | lasso | 3 | 0.07 | 2.9e-06 | 6.7 | -6.6 | 3.8e-11 | -0.85 | 0.02 | 0.97 | FALSE |
21 | GTEx | Thyroid | ASB16-AS1 | 0.14 | 0.06 | lasso | 2 | 0.04 | 5.4e-04 | 6.7 | -6.7 | 1.6e-11 | -0.89 | 0.08 | 0.86 | FALSE |
22 | GTEx | Whole Blood | ASB16 | 0.11 | 0.03 | enet | 24 | 0.03 | 6.3e-04 | 6.4 | -5.3 | 1.5e-07 | -0.63 | 0.11 | 0.63 | FALSE |
23 | GTEx | Whole Blood | ASB16-AS1 | 0.14 | 0.05 | lasso | 6 | 0.04 | 3.1e-04 | 6.7 | -6.8 | 9.9e-12 | -0.90 | 0.10 | 0.90 | FALSE |
24 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ASB16 | 0.03 | 0.01 | enet | 4 | 0.02 | 1.2e-02 | 6.4 | -5.8 | 5.0e-09 | -0.82 | 0.02 | 0.53 | FALSE |
25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf65 | 0.03 | 0.00 | blup | 37 | 0.01 | 2.3e-02 | 6.7 | -7.3 | 2.1e-13 | -0.92 | 0.02 | 0.86 | TRUE |
26 | The Cancer Genome Atlas | Colon Adenocarcinoma | ASB16 | 0.05 | 0.06 | blup | 40 | 0.05 | 4.6e-04 | 6.4 | -6.7 | 2.2e-11 | -0.90 | 0.04 | 0.89 | FALSE |
27 | The Cancer Genome Atlas | Colon Adenocarcinoma | C17orf65 | 0.05 | 0.06 | blup | 38 | 0.05 | 4.2e-04 | 5.3 | -6.8 | 1.0e-11 | -0.90 | 0.08 | 0.81 | FALSE |
28 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ASB16 | 0.02 | 0.02 | blup | 39 | 0.02 | 3.8e-03 | 7.3 | -7.2 | 5.1e-13 | -0.90 | 0.01 | 0.56 | FALSE |
29 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf65 | 0.03 | 0.01 | lasso | 10 | 0.02 | 3.6e-03 | 6.5 | -6.9 | 5.7e-12 | -0.82 | 0.03 | 0.85 | FALSE |
30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ASB16 | 0.02 | 0.03 | blup | 40 | 0.03 | 1.3e-04 | 6.4 | -6.9 | 5.9e-12 | -0.89 | 0.12 | 0.86 | FALSE |
31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C17orf65 | 0.05 | 0.05 | lasso | 2 | 0.05 | 2.5e-06 | 5.3 | -5.6 | 1.8e-08 | -0.78 | 0.12 | 0.88 | FALSE |
32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASB16 | 0.03 | 0.03 | lasso | 3 | 0.03 | 3.2e-04 | 6.2 | -6.3 | 2.3e-10 | -0.85 | 0.13 | 0.76 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf65 | 0.04 | 0.04 | blup | 37 | 0.03 | 1.4e-04 | 6.7 | -6.5 | 1.1e-10 | -0.86 | 0.14 | 0.84 | FALSE |
34 | The Cancer Genome Atlas | Lung Adenocarcinoma | ASB16 | 0.02 | 0.02 | lasso | 4 | 0.01 | 6.3e-03 | 6.7 | -6.1 | 1.3e-09 | -0.83 | 0.05 | 0.54 | FALSE |
35 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ASB16 | 0.04 | 0.04 | lasso | 4 | 0.03 | 1.8e-04 | 7.3 | -7.3 | 3.6e-13 | -0.99 | 0.01 | 0.99 | FALSE |
36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C17orf65 | 0.07 | 0.05 | lasso | 6 | 0.05 | 3.1e-06 | 6.7 | -6.5 | 5.9e-11 | -0.88 | 0.02 | 0.97 | FALSE |
37 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C17orf65 | 0.04 | 0.03 | blup | 39 | 0.03 | 2.7e-03 | 7.3 | -6.4 | 1.2e-10 | -0.89 | 0.01 | 0.92 | FALSE |
38 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C17orf65 | 0.09 | 0.02 | blup | 38 | 0.04 | 8.0e-03 | 6.7 | -6.1 | 1.2e-09 | -0.86 | 0.01 | 0.60 | FALSE |
39 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C17orf65 | 0.09 | 0.09 | enet | 8 | 0.08 | 2.9e-04 | 6.2 | -6.8 | 7.5e-12 | -0.91 | 0.03 | 0.93 | FALSE |
40 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C17orf65 | 0.15 | 0.05 | blup | 37 | 0.09 | 1.7e-03 | 6.7 | -6.0 | 1.7e-09 | -0.83 | 0.02 | 0.64 | FALSE |
41 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C17orf65 | 0.07 | 0.02 | blup | 38 | 0.04 | 1.1e-02 | 6.2 | -7.0 | 3.1e-12 | -0.86 | 0.03 | 0.18 | FALSE |
42 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf65 | 0.03 | 0.03 | lasso | 7 | 0.03 | 3.8e-04 | 6.7 | -7.1 | 1.8e-12 | -0.94 | 0.02 | 0.93 | FALSE |