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chr17:39,993,748-41,538,783

Best TWAS P=3.54e-10 · Best GWAS P=1.97e-08 conditioned to 0.00909

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Caudate basal ganglia	TUBG2	0.39	0.24	enet	45	0.25	7.7e-08	-5.1	-6.3	3.5e-10	-0.67	0.05	0.95	TRUE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	RND2	0.08	0.00	enet	16	0.02	3.5e-03	-3.8	5.5	4.7e-08	0.06	0.00	0.01	TRUE
29	NTR	Blood	TUBG2	0.01	0.00	blup	247	0.01	4.0e-03	-4.4	6.1	1.0e-09	0.39	0.08	0.84	FALSE
14	GTEx	Esophagus Mucosa	TUBG2	0.09	0.09	lasso	4	0.11	5.5e-08	-5.2	-6.0	1.8e-09	-0.84	0.03	0.97	FALSE
26	GTEx	Thyroid	HSD17B1P1	0.04	0.00	enet	9	0.00	2.2e-01	-5.2	-5.9	4.0e-09	-0.74	0.04	0.82	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMC3IP	0.02	0.02	blup	33	0.02	9.8e-04	-5.2	-5.7	9.4e-09	-0.78	0.02	0.82	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	TUBG2	0.15	0.13	lasso	5	0.12	4.0e-07	5.6	-5.7	9.9e-09	-0.99	0.01	0.99	FALSE
23	GTEx	Skin Sun Exposed Lower leg	TUBG2	0.14	0.10	enet	25	0.12	4.9e-10	-5.1	-5.7	1.1e-08	-0.83	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B1	0.05	0.07	blup	29	0.07	2.3e-07	-4.7	-5.7	1.5e-08	-0.76	0.14	0.85	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	TUBG2	0.04	0.02	blup	29	0.02	1.5e-03	-5.1	-5.6	1.7e-08	-0.70	0.01	0.86	FALSE
2	GTEx	Adipose Subcutaneous	TUBG2	0.21	0.18	enet	17	0.26	2.1e-21	-4.7	-5.5	3.6e-08	-0.75	0.10	0.90	FALSE
5	GTEx	Artery Tibial	RP11-400F19.6	0.07	0.01	lasso	5	0.01	3.0e-02	5.6	-5.5	4.0e-08	-0.97	0.01	0.99	FALSE
25	GTEx	Stomach	HSD17B1P1	0.10	0.04	lasso	3	0.04	6.9e-03	4.0	-5.5	4.3e-08	-0.76	0.05	0.62	FALSE
16	GTEx	Esophagus Muscularis	TUBG2	0.14	0.16	enet	17	0.06	2.1e-04	-5.1	-5.4	5.3e-08	-0.66	0.06	0.94	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B1	0.30	0.05	enet	14	0.06	2.8e-07	-4.9	-5.4	5.3e-08	-0.71	0.06	0.93	FALSE
11	GTEx	Cells Transformed fibroblasts	TUBG2	0.16	0.18	lasso	4	0.17	6.5e-13	-5.1	-5.4	8.1e-08	-0.66	0.05	0.95	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B1	0.02	0.03	blup	30	0.03	4.0e-04	-4.8	-5.3	8.8e-08	-0.66	0.07	0.86	FALSE
21	GTEx	Nerve Tibial	TUBG2	0.26	0.28	enet	39	0.28	2.2e-20	-4.8	-5.3	1.1e-07	-0.75	0.15	0.84	FALSE
19	GTEx	Lung	TUBG2	0.08	0.02	enet	8	0.04	7.8e-04	-5.2	-5.3	1.2e-07	-0.74	0.05	0.85	FALSE
8	GTEx	Brain Frontal Cortex BA9	TUBG2	0.33	0.26	lasso	4	0.18	1.9e-05	-5.1	-5.3	1.3e-07	-0.56	0.06	0.93	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	HSD17B1	0.03	0.01	blup	30	0.01	1.5e-01	-5.2	-5.3	1.3e-07	-0.61	0.02	0.50	FALSE
4	GTEx	Artery Tibial	HSD17B1	0.12	0.07	lasso	9	0.07	4.4e-06	-5.2	-5.3	1.4e-07	-0.60	0.05	0.95	FALSE
7	GTEx	Brain Cortex	TUBG2	0.36	0.36	enet	15	0.32	1.1e-09	-5.1	-5.3	1.4e-07	-0.60	0.06	0.94	FALSE
28	METSIM	Adipose	TUBG2	0.08	0.09	lasso	6	0.09	5.2e-13	4.1	-5.3	1.4e-07	-0.79	0.34	0.65	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	CNTNAP1	0.04	0.03	blup	27	0.05	2.7e-05	-4.8	5.3	1.4e-07	0.55	0.03	0.94	FALSE
10	GTEx	Breast Mammary Tissue	TUBG2	0.15	0.06	enet	18	0.08	4.5e-05	-4.7	-5.3	1.5e-07	-0.71	0.15	0.84	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TUBG1	0.04	0.06	lasso	1	0.05	8.3e-05	-5.2	5.2	1.7e-07	0.59	0.04	0.92	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	CNTNAP1	0.06	0.05	blup	27	0.03	7.3e-03	-4.7	5.2	1.7e-07	0.55	0.02	0.86	FALSE
17	GTEx	Esophagus Muscularis	RP11-400F19.8	0.17	0.05	lasso	4	0.02	3.9e-02	5.0	-5.2	1.8e-07	-0.70	0.05	0.37	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	TUBG2	0.02	0.01	lasso	2	0.01	1.7e-02	4.6	-5.2	1.8e-07	-0.86	0.01	0.35	FALSE
9	GTEx	Brain Putamen basal ganglia	TUBG2	0.17	0.12	lasso	5	0.09	3.7e-03	-5.2	-5.2	2.0e-07	-0.58	0.05	0.76	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	TUBG2	0.07	0.01	enet	7	0.02	2.2e-03	4.6	-5.2	2.0e-07	-0.80	0.01	0.41	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TUBG2	0.14	0.25	lasso	3	0.25	1.1e-29	-5.2	-5.2	2.1e-07	-0.57	0.05	0.95	FALSE
13	GTEx	Colon Transverse	HSD17B1	0.15	0.14	lasso	11	0.12	1.7e-06	-5.2	-5.2	2.2e-07	-0.59	0.05	0.95	FALSE
15	GTEx	Esophagus Mucosa	HSD17B1P1	0.04	0.06	lasso	5	0.05	1.9e-04	-5.2	-5.2	2.2e-07	-0.59	0.05	0.93	FALSE
12	GTEx	Cells Transformed fibroblasts	MLX	0.04	0.03	enet	8	0.00	3.3e-01	-5.1	-5.2	2.3e-07	-0.61	0.06	0.82	FALSE
3	GTEx	Adipose Subcutaneous	HSD17B1	0.06	0.07	enet	5	0.06	6.8e-06	-5.2	-5.2	2.4e-07	-0.58	0.05	0.95	FALSE
27	METSIM	Adipose	HSD17B1	0.08	0.08	lasso	6	0.06	3.1e-09	-5.2	-5.2	2.4e-07	-0.58	0.05	0.95	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	TUBG2	0.20	0.13	blup	29	0.17	1.7e-16	4.6	-5.2	2.5e-07	-0.84	0.05	0.94	FALSE
18	GTEx	Heart Atrial Appendage	TUBG2	0.07	0.05	lasso	2	0.02	2.9e-02	-5.0	-5.1	3.0e-07	-0.57	0.06	0.77	FALSE
20	GTEx	Lung	CNTNAP1	0.06	0.00	enet	16	0.02	1.5e-02	-4.7	5.1	3.1e-07	0.69	0.04	0.77	FALSE