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chr3:93,537,290-94,472,527

Best TWAS P=3.41e-11 · Best GWAS P=1.59e-18 conditioned to 1.96e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STX19	0.35	0.11	enet	12	0.20	2.4e-22	6.3	6.6	3.4e-11	0.49	0.04	0.96	TRUE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DHFRL1	0.07	0.05	enet	17	0.05	2.5e-06	5.9	-6.5	5.6e-11	-0.54	0.05	0.91	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	ARL13B	0.03	0.00	blup	39	0.00	2.1e-01	-7.0	6.4	1.2e-10	0.66	0.01	0.68	FALSE
2	METSIM	Adipose	STX19	0.06	0.09	lasso	3	0.08	1.8e-11	5.9	6.4	1.9e-10	0.50	1.00	0.00	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	STX19	0.04	0.02	lasso	1	0.01	5.5e-04	6.3	6.2	4.0e-10	0.64	0.02	0.77	FALSE
14	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	STX19	0.15	0.08	lasso	1	0.05	1.8e-03	6.3	6.2	4.0e-10	0.64	0.02	0.54	FALSE
3	YFS	Blood	DHFRL1	0.07	0.04	lasso	9	0.04	4.1e-14	6.7	6.1	8.9e-10	0.54	1.00	0.00	FALSE
6	The Cancer Genome Atlas	Glioblastoma Multiforme	DHFRL1	0.20	0.12	lasso	8	0.11	3.7e-04	5.9	-6.0	1.9e-09	-0.44	0.01	0.09	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	STX19	0.28	-0.01	enet	15	0.08	6.4e-04	6.3	6.0	2.0e-09	0.44	0.00	0.27	FALSE
4	The Cancer Genome Atlas	Breast Invasive Carcinoma	DHFRL1	0.07	0.05	lasso	1	0.05	3.4e-11	5.9	-5.9	3.5e-09	-0.43	0.82	0.18	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHFRL1	0.13	0.07	lasso	2	0.07	5.7e-08	5.9	-5.9	3.5e-09	-0.43	0.80	0.19	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHFRL1	0.10	0.06	lasso	2	0.05	5.2e-06	5.9	-5.9	3.5e-09	-0.43	0.79	0.19	FALSE
1	GTEx	Heart Atrial Appendage	PROS1	0.31	0.16	enet	7	0.19	8.4e-09	6.4	-5.8	5.3e-09	-0.68	0.96	0.02	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	STX19	0.51	0.13	enet	19	0.34	3.9e-40	6.3	5.7	1.5e-08	0.40	0.41	0.59	FALSE
7	The Cancer Genome Atlas	Glioblastoma Multiforme	STX19	0.52	-0.01	enet	15	0.17	5.6e-06	6.3	5.5	3.9e-08	0.30	0.00	0.16	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	STX19	0.24	0.03	enet	10	0.09	2.4e-09	6.3	5.5	4.4e-08	0.36	0.01	0.46	FALSE
11	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	STX19	0.60	0.12	enet	25	0.36	2.4e-21	6.3	5.3	9.0e-08	0.33	0.01	0.99	FALSE