Hub : Genes

DHFRL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0440	4.1e-03	0.005	0.016	0.004	0.017	0.010	6.9e-02	4.2e-03	8.8e-02	3.0e-03	1.8e-02
2	YFS	Blood	0.0717	0.0319	2.1e-10	0.042	0.031	0.040	0.035	0.044	1.0e-13	1.6e-10	5.7e-13	1.7e-11	4.1e-14
3	TCGA	Breast Invasive Carcinoma	0.0730	0.0315	1.2e-08	0.054	0.038	0.052	NA	0.054	3.3e-11	2.5e-08	6.5e-11	NA	3.4e-11
4	TCGA	Glioblastoma Multiforme	0.1950	0.1010	6.8e-03	0.116	0.089	0.076	NA	0.108	2.3e-04	1.2e-03	2.5e-03	NA	3.7e-04
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0728	0.0361	2.3e-05	0.046	0.038	0.050	NA	0.040	6.8e-06	3.7e-05	2.5e-06	NA	2.2e-05
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1289	0.0665	9.6e-06	0.069	0.054	0.065	NA	0.067	3.2e-08	1.1e-06	8.3e-08	NA	5.7e-08
7	TCGA	Brain Lower Grade Glioma	0.1009	0.0433	5.1e-06	0.058	0.035	0.042	NA	0.046	3.7e-07	6.5e-05	1.3e-05	NA	5.2e-06
8	TCGA	Skin Cutaneous Melanoma	0.1320	0.0740	7.0e-03	0.016	0.062	0.043	NA	0.036	1.2e-01	9.7e-03	2.7e-02	NA	3.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.2	1.9	3.5	-0.5	1.9	-1.4	-1.4	-1.6	-1.4	-1.4	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	1.0	0.9	0.2	0.1	-0.5	0.2	0.2	1.0
Depressed Affect (Nagel 2018)	0.5	1.2	1.5	-0.7	1.1	-1.2	-1.2	-1.0	-1.2	-1.2	-0.6
Depression (Nagel 2018)	0.1	0.2	1.3	-1.2	-0.4	0.1	0.2	0.4	0.1	0.1	-0.0
Intelligence (Savage-Jansen 2018)	5.3	16.4	26.5	2.0	-2.6	4.7	5.0	5.2	4.7	4.7	1.3
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-0.6	0.8	-0.7	-0.8	-1.0	-0.7	-0.7	-0.6
Schizophrenia (2018)	0.9	2.0	4.7	1.7	-0.4	1.4	1.3	0.6	1.4	1.4	2.2
Schizophrenia vs Biploar Disorder	3.7	4.9	5.8	1.3	-2.3	2.4	2.2	2.2	2.4	2.4	2.4
Worry (Nagel 2018)	0.3	0.5	1.3	-1.1	-1.1	0.7	0.6	0.1	0.7	0.7	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	1.6	-0.2	1.3	0.0	0.1	0.4	0.0	0.0	0.2
Alzheimer’s Disease (in father)	3.2	3.5	4.5	1.2	-2.1	2.0	2.1	2.0	2.0	2.0	1.0
Alzheimer’s Disease (including proxy)	1.1	1.6	3.4	0.7	-0.8	1.3	1.4	1.9	1.3	1.3	0.9
Crohns Disease (2017)	0.2	0.4	1.5	-1.2	0.1	-0.3	-0.3	-0.2	-0.3	-0.3	-1.2
Irritable Bowel Disease (IBD)	1.4	3.3	4.2	-2.0	1.3	-2.0	-1.8	-1.1	-2.0	-2.0	-2.0
Ulcerative Colitis (UC)	1.5	2.8	4.0	-1.9	1.0	-1.9	-1.7	-0.8	-1.9	-1.9	-2.0
Major Depression (MDD)	1.4	1.7	6.0	-1.8	2.4	-0.4	-0.3	-0.5	-0.4	-0.4	-1.9
Reaction Time	0.5	0.9	1.2	-0.6	1.1	-1.0	-1.1	-0.9	-1.0	-1.0	-1.1
Verbal and Numeric Reasoning (VNR)	3.0	7.2	10.8	0.2	-1.9	3.3	3.3	3.2	3.3	3.3	1.2
Breast Cancer	0.2	0.6	1.0	-0.9	0.1	-0.8	-1.0	-1.0	-0.8	-0.8	-0.3
Ovarian Cancer	1.5	2.0	2.4	1.5	-1.2	1.6	1.4	1.0	1.6	1.6	1.4
Prostate Cancer	0.8	1.1	4.5	0.3	-2.1	0.8	0.8	1.1	0.8	0.8	0.5
Age at First Birth	2.7	3.9	6.3	1.4	-2.5	1.9	2.0	2.4	1.9	1.9	1.8
Bipolar Disorder (2011)	1.3	1.2	6.5	-1.2	2.5	0.0	0.0	0.0	-1.4	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	0.9	1.1	-0.7	-0.7	-1.3	-0.7	-0.7	-0.5
Coronary Artery Disease (CAD)	0.2	0.3	1.5	0.2	0.7	0.3	0.1	0.1	0.3	0.3	1.2
Crohns Disease (2012)	0.1	0.2	0.9	0.1	1.0	-0.1	0.0	0.5	-0.1	-0.1	0.6
Mean Putamen Volume	0.3	0.4	1.7	1.0	0.1	-0.0	0.4	1.3	-0.0	-0.0	-0.3
Fasting Glucose	0.8	1.0	3.3	1.1	1.1	-0.7	-0.9	-1.8	-0.7	-0.7	-0.2
HbA1C	1.0	1.2	2.1	-0.7	0.2	-1.2	-1.2	-1.5	-1.2	-1.2	-0.9
HDL Cholesterol	1.3	2.2	3.0	-1.7	-0.2	-1.5	-1.7	-1.7	-1.5	-1.5	-1.4
LDL Cholesterol	0.2	0.3	0.6	-0.4	0.7	-0.6	-0.3	0.4	-0.6	-0.6	-0.8
Lupus	0.1	0.2	0.7	-0.5	-0.8	-0.1	-0.2	-0.2	-0.1	-0.1	0.5
Neuroticism (2016)	0.2	0.2	1.3	-0.4	1.1	0.1	0.0	0.6	0.1	0.1	-0.3
Primary Biliary Cirrhosis	0.8	1.2	2.5	-0.6	0.5	-1.1	-1.2	-1.2	-1.1	-1.1	-1.6
Rheumatoid Arthritis	0.4	0.6	1.2	0.3	-1.0	0.7	1.0	0.5	0.7	0.7	-1.1
Schizophrenia (2014)	1.2	2.7	4.2	1.3	-0.5	1.9	1.7	1.1	1.9	1.9	2.1
Triglycerides	0.2	0.4	2.9	-0.3	1.7	0.2	0.1	-0.2	0.2	0.2	0.1
Type 2 Diabetes (T2D) (2012)	2.3	2.6	3.8	1.2	1.3	-2.0	-1.7	-1.8	-2.0	-2.0	-0.3
Ulcerative Colitis	2.0	2.9	3.9	-1.7	1.6	-2.0	-1.9	-1.1	-2.0	-2.0	-1.2
Blood Eosinophil Count	0.3	2.7	10.0	0.7	3.2	-1.5	-1.3	-1.1	-1.5	-1.5	-0.8
Blood Platelet Count	0.1	1.3	3.9	2.0	0.0	0.5	1.0	2.0	0.5	0.5	0.7
Blood Red Count	0.2	1.7	3.0	-0.6	-0.0	1.7	1.6	0.9	1.7	1.7	-0.9
Blood White Count	0.2	1.6	8.4	1.2	2.9	-0.9	-0.6	0.0	-0.9	-0.9	-0.3
Heel T-Score	0.3	2.4	3.3	1.8	-0.8	-1.7	-1.5	-1.6	-1.7	-1.7	1.3
BMI	6.8	39.6	62.7	-0.5	7.2	-6.8	-6.9	-7.9	-6.8	-6.8	-4.1
Height	0.0	0.7	4.4	0.7	-0.0	0.2	-0.1	-0.4	0.2	0.2	2.1
Waist Hip Ratio (WHR)	0.1	0.3	1.5	0.1	1.2	0.1	-0.3	-0.5	0.1	0.1	0.6
Systolic Blood Pressure	0.1	0.7	2.8	1.0	-1.7	0.2	0.4	0.4	0.2	0.2	1.2
Smoking Status	3.5	8.5	11.8	0.5	3.4	-3.4	-3.3	-2.8	-3.4	-3.4	-1.5
Allergy or Eczema	0.2	0.5	1.5	-0.2	0.9	-0.7	-0.8	-1.2	-0.7	-0.7	-0.3
Cardiovascular Disease	0.7	2.2	4.3	0.5	1.6	-1.4	-1.5	-2.1	-1.4	-1.4	-1.3
Hypothyroidism (self reported)	0.2	0.4	1.8	-1.3	0.2	-0.0	-0.0	-0.1	-0.0	-0.0	-1.2
Respiratory disease	1.7	3.9	8.0	-0.8	1.7	-1.9	-2.1	-2.8	-1.9	-1.9	-2.1
Type 2 Diabetes (T2D) (2018)	3.9	7.2	11.6	-1.1	3.4	-2.9	-3.0	-3.1	-2.9	-2.9	-1.2
Lung FEV1/FVC ratio	1.8	9.3	14.5	-2.0	2.5	-3.1	-3.2	-3.8	-3.1	-3.1	-3.1
Lung FVC	0.1	0.8	3.5	0.5	-0.7	-0.1	0.2	1.3	-0.1	-0.1	1.9
Neuroticism	0.6	1.4	1.9	-1.3	1.4	-1.1	-1.3	-1.4	-1.1	-1.1	-0.5
Chronotype (morning person)	0.1	0.2	1.0	-1.0	-0.2	0.1	0.0	-0.3	0.1	0.1	-0.8
Hair Pigment	0.0	0.9	1.8	-0.1	0.1	-1.3	-1.2	-0.7	-1.3	-1.3	-0.3
Tanning	0.2	2.7	10.0	3.2	0.8	-1.4	-1.0	0.1	-1.4	-1.4	2.0
Hand grip strength (left)	0.2	0.5	1.6	-0.4	-1.0	0.3	0.4	1.0	0.3	0.3	1.3
Number of treatments/medications taken	1.7	3.0	6.4	-0.6	1.1	-1.6	-1.7	-2.5	-1.6	-1.6	-2.4
Average weekly spirits intake	4.2	5.2	7.2	-0.4	2.6	-2.7	-2.4	-2.2	-2.7	-2.7	-1.3
Sensitivity / hurt feelings	0.2	0.4	1.7	-0.6	1.3	-0.2	-0.3	-0.7	-0.2	-0.2	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	-0.8	0.4	-0.3	-0.1	0.8	-0.3	-0.3	0.1
Hearing difficulty/problems: Yes	0.5	0.8	4.0	2.0	0.9	0.2	0.5	0.9	0.2	0.2	0.4
Relative age of first facial hair	0.1	0.3	1.2	-1.1	0.8	-0.0	-0.3	-0.6	-0.0	-0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.1	0.3	-0.2	-0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	1.3	-0.6	0.0	-0.1	-0.9	0.0	0.0	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	0.7	0.0	0.6	-0.9	-0.7	-0.6	-0.9	-0.9	-0.7
Systolic blood pressure, automated reading	0.2	0.7	1.6	1.1	-0.2	-0.8	-0.7	-0.8	-0.8	-0.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.0	0.2	1.7	-0.2	-0.4	-1.1	-0.2	-0.2	-0.9
Angina	0.7	1.0	1.6	0.4	-0.5	1.2	1.3	1.1	1.2	1.2	-0.3
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	-0.7	-0.4	-0.4	-0.7	-0.4	-0.4	-0.6
Vitamin and mineral supplements	0.4	0.5	1.4	-1.2	1.0	0.1	-0.0	-0.3	0.1	0.1	-1.2
Supplements: Zinc	0.2	0.2	0.7	0.4	-0.5	0.4	0.5	0.9	0.4	0.4	0.2
Medication: Co-codamol	0.9	1.1	4.5	0.7	2.1	-0.8	-0.9	-0.7	-0.8	-0.8	0.7
Medication: Metformin	5.6	7.9	11.9	-0.3	2.9	-3.2	-3.2	-3.5	-3.2	-3.2	-0.9
Diabetes (father)	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.2	-0.5	-0.3	-0.3	-0.2
Diabetes (mother)	1.6	2.0	5.0	1.0	2.2	-1.2	-1.4	-1.8	-1.2	-1.2	-0.8
Severe depression (siblings)	0.3	0.4	0.5	0.5	-0.2	0.7	0.7	0.5	0.7	0.7	0.7
Pack years adult smoking proportion	1.1	1.7	5.2	2.3	1.6	-1.3	-0.8	-0.3	-1.3	-1.3	-0.0
Impedance of leg (right)	1.6	7.9	13.9	-0.3	-3.7	2.8	2.6	2.7	2.8	2.8	3.4
Leg fat-free mass (left)	2.9	15.4	20.4	0.6	4.5	-4.4	-4.4	-4.5	-4.4	-4.4	-2.2
Trunk fat percentage	6.6	26.4	39.3	-0.3	6.0	-5.7	-5.8	-6.3	-5.7	-5.7	-2.1
Hand grip strength (right)	0.3	0.9	2.4	-1.3	-1.5	0.5	0.5	1.2	0.5	0.5	0.5
Townsend deprivation index at recruitment	2.6	3.7	5.4	-0.7	1.9	-2.0	-2.0	-1.9	-2.0	-2.0	-2.3
Current tobacco smoking	1.3	2.2	3.5	0.4	1.5	-1.9	-1.8	-1.2	-1.9	-1.9	-0.2
Average weekly fortified wine intake	0.2	0.3	0.6	-0.8	-0.7	-0.6	-0.5	-0.2	-0.6	-0.6	-0.0
Maternal smoking around birth	3.1	4.5	8.2	-0.4	2.0	-2.4	-2.5	-2.9	-2.4	-2.4	-0.9
Fed-up feelings	2.2	3.9	5.4	-2.2	2.0	-2.1	-2.3	-2.1	-2.1	-2.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.9	-0.4	-0.9	0.7	0.9	1.7	0.7	0.7	-0.3
Relative age voice broke	0.3	0.5	2.0	-1.4	-1.1	-0.0	-0.2	-0.6	-0.0	-0.0	0.4
Taking other prescription medications	1.0	1.6	2.2	0.5	1.4	-1.5	-1.4	-1.3	-1.5	-1.5	-0.3
Age when periods started (menarche)	0.1	0.3	1.0	-1.0	0.0	-0.6	-0.6	-0.3	-0.6	-0.6	0.4
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	5.3	0.6	2.3	-1.7	-1.4	-1.2	-1.7	-1.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	0.7	-0.1	-1.7	-1.6	-1.6	-1.7	-1.7	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.1	1.1	0.3	-1.5	-1.2	-0.6	-1.5	-1.5	0.3
Qualifications: CSEs or equivalent	0.5	0.7	2.0	1.4	-1.1	0.2	0.5	1.1	0.2	0.2	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.1	0.0	0.7	-1.1	-0.8	-0.3	-1.1	-1.1	0.8
High blood pressure	0.2	0.5	2.3	1.5	1.2	-0.3	-0.1	-0.3	-0.3	-0.3	0.1
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.3	-0.9	1.8	-1.4	-1.5	-2.1	-1.4	-1.4	-0.9
Multivitamins +/- minerals	0.3	0.4	1.3	1.0	-1.1	0.3	0.2	0.1	0.3	0.3	0.8
Stomach or abdominal pain in last month	0.2	0.3	1.6	-0.1	-0.6	0.2	0.4	1.2	0.2	0.2	0.0
Supplements: Glucosamine	1.2	1.6	4.1	2.0	-1.5	1.1	1.0	0.8	1.1	1.1	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	-0.3	0.2	-0.3	-0.2	0.3	-0.3	-0.3	0.7
Medication: Atenolol	0.6	0.8	3.6	-0.4	1.9	-0.3	-0.5	-1.2	-0.3	-0.3	-0.7
Medication: Levothyroxine sodium	0.0	0.1	0.2	-0.1	0.1	-0.3	-0.0	0.5	-0.3	-0.3	0.1
Sitting height	0.4	2.8	4.7	-0.8	0.7	-2.0	-2.2	-1.9	-2.0	-2.0	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.6	1.3	0.4	-0.3	-0.3	-0.2	-0.3	-0.3	0.5
High blood pressure (mother)	0.2	0.3	0.7	0.1	-0.8	0.3	0.1	-0.8	0.3	0.3	-0.7
Body mass index (BMI)	5.4	23.1	34.6	0.2	5.6	-5.1	-5.2	-5.9	-5.1	-5.1	-3.5
Impedance of leg (left)	1.4	7.0	13.0	-0.7	-3.6	2.7	2.4	2.6	2.7	2.7	2.9
Leg predicted mass (left)	3.0	15.7	20.3	0.5	4.5	-4.5	-4.5	-4.5	-4.5	-4.5	-2.1
Trunk fat mass	6.2	26.7	39.6	-0.1	5.9	-5.8	-5.8	-6.3	-5.8	-5.8	-2.4
Waist circumference	4.8	17.7	30.5	-0.2	5.5	-4.3	-4.5	-5.2	-4.3	-4.3	-2.9
Number of incorrect matches in round	0.4	0.6	2.2	-0.2	1.5	-0.7	-0.6	-0.5	-0.7	-0.7	-0.8
Past tobacco smoking	3.0	5.6	7.8	-1.8	-2.5	2.5	2.5	2.8	2.5	2.5	1.7
Alcohol usually taken with meals	0.6	0.9	1.6	1.2	-0.9	0.8	0.7	0.9	0.8	0.8	1.3
Nervous feelings	0.8	1.5	2.8	-0.6	-1.7	1.5	1.3	0.7	1.5	1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	-0.6	-0.0	0.9	1.0	1.2	0.9	0.9	-0.7
Hearing difficulty/problems with background noise	0.3	0.4	2.1	0.2	0.4	0.1	0.5	0.9	0.1	0.1	-1.4
Hair/balding pattern: Pattern 2	0.5	0.6	0.7	-0.2	-0.8	0.9	0.8	0.8	0.9	0.9	0.7
Had menopause	1.6	2.0	3.1	1.4	-0.4	1.8	1.6	0.9	1.8	1.8	1.0
Had other major operations	1.3	1.6	3.5	-0.3	1.9	-1.5	-1.4	-0.8	-1.5	-1.5	0.2
Forced vital capacity (FVC)	0.4	1.4	5.9	0.1	-1.3	0.4	0.5	1.7	0.4	0.4	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	1.8	0.8	-0.9	-1.4	-1.3	-1.3	-1.4	-1.4	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.4	0.4	1.2	0.5	0.6	0.3	0.5	0.5	-0.2
Qualifications: None of the above	1.9	4.1	7.8	1.8	2.2	-2.0	-2.1	-2.8	-2.0	-2.0	0.3
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.1	0.8	-0.8	-0.5	0.0	-0.8	-0.8	-0.2
Mouth/teeth dental problems	0.4	0.7	0.9	-0.5	-0.9	0.9	1.0	1.0	0.9	0.9	-0.4
Heart attack	0.3	0.4	1.2	1.1	-0.6	0.6	0.3	-0.3	0.6	0.6	-0.4
Allergy	3.3	7.6	12.7	2.3	-2.6	2.7	3.0	3.6	2.7	2.7	2.1
Pain all over the body in last month	1.3	1.4	4.4	-0.4	-0.2	-1.1	-1.4	-2.1	-1.1	-1.1	-1.0
Diabetes (self-reported)	2.6	4.0	7.3	0.1	2.7	-2.2	-2.1	-2.5	-2.2	-2.2	-0.7
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	4.6	-1.1	2.0	-2.2	-2.0	-1.9	-2.2	-2.2	-0.9
Medication: Ramipril	0.0	0.1	0.1	0.4	0.2	0.1	0.2	0.4	0.1	0.1	0.3
Medication: Simvastatin	1.8	2.7	14.0	-1.2	0.6	-0.7	-0.7	-1.9	-0.7	-0.7	-3.7
Fluid intelligence score	3.2	6.6	10.9	0.0	-1.8	3.0	3.3	3.2	3.0	3.0	0.2
Illnesses of siblings	0.9	1.3	2.5	0.2	-1.6	1.2	1.3	1.2	1.2	1.2	1.0
Neuroticism score	0.1	0.3	0.8	-0.9	0.8	-0.1	-0.2	-0.3	-0.1	-0.1	-0.7
Weight	4.3	21.2	31.8	0.2	5.1	-5.1	-5.2	-5.6	-5.1	-5.1	-2.6
Impedance of arm (right)	0.1	0.6	2.1	-1.4	-0.5	0.4	0.2	0.6	0.4	0.4	1.4
Arm fat percentage (right)	7.6	30.1	46.1	-0.5	6.8	-5.9	-5.9	-6.5	-5.9	-5.9	-3.5
Trunk fat-free mass	0.8	4.7	6.3	1.3	1.8	-2.5	-2.4	-2.5	-2.5	-2.5	-1.2
Hip circumference	3.4	14.5	22.0	-0.5	4.7	-4.0	-4.0	-4.5	-4.0	-4.0	-3.1
Time employed in main current job	0.3	0.4	1.9	-1.4	0.3	0.4	0.4	0.5	0.4	0.4	-0.2
Alcohol intake versus 10 years previously	0.5	0.8	3.8	0.5	1.3	-0.2	-0.3	-0.4	-0.3	-0.3	-2.0
Father’s age at death	0.8	1.1	4.3	-0.6	-2.1	0.7	0.8	1.1	0.7	0.7	0.9
Worrier / anxious feelings	0.5	1.0	1.5	-0.1	-0.8	1.1	1.1	1.2	1.1	1.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	0.9	-0.3	0.9	0.9	1.5	0.9	0.9	0.7
Falls in the last year	0.3	0.5	0.7	-0.9	0.6	-0.6	-0.7	-0.8	-0.6	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.4	0.6	3.0	-1.7	0.7	0.3	0.2	0.4	0.3	0.3	-1.0
Number of live births	0.1	0.1	0.4	-0.1	0.5	-0.1	-0.0	-0.1	-0.1	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.1	-0.8	-1.3	0.1	0.2	1.0	0.1	0.1	1.8
Pulse rate	2.5	4.2	7.1	0.9	2.7	-2.2	-2.3	-2.4	-2.2	-2.2	0.4
Happiness	1.6	1.9	4.0	-0.6	2.0	-1.6	-1.5	-1.2	-1.6	-1.6	-0.3
Noisy workplace	0.7	0.9	3.9	2.0	0.7	-0.8	-0.7	-0.2	-0.8	-0.8	0.7
Qualifications: A levels/AS levels or equivalent	2.4	5.2	8.1	-2.5	-2.8	2.2	2.4	2.8	2.2	2.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.3	0.4	-0.9	1.1	1.2	1.5	1.1	1.1	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	2.5	0.3	-0.9	1.6	1.4	0.5	1.6	1.6	-0.6
Asthma	3.9	7.7	10.2	-1.5	1.5	-3.2	-3.1	-3.2	-3.2	-3.2	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.1	-0.1	-0.8	-0.8	-0.7	-0.8	-0.8	-0.3
Medication: Cholesterol lowering	1.2	1.8	9.6	-1.6	-0.3	-0.2	-0.4	-1.4	-0.2	-0.2	-3.1
Depression (self-reported)	0.9	1.0	2.5	-1.6	1.5	-0.7	-0.9	-1.0	-0.7	-0.7	-0.4
Medication: Lansoprazole	0.3	0.3	2.0	1.4	-0.0	0.2	0.1	0.0	0.2	0.2	-0.7
Prospective memory result	2.6	3.2	6.3	-0.1	2.5	-1.9	-2.0	-2.2	-1.9	-1.9	-0.2
Lung cancer (father)	1.7	2.0	3.2	-0.9	1.7	-1.8	-1.6	-0.6	-1.8	-1.8	-0.2
Illnesses of mother	0.2	0.3	0.4	-0.4	0.2	-0.7	-0.3	0.6	-0.7	-0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	-1.2	-0.5	-0.6	-0.6	0.1	-0.6	-0.6	1.2
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	1.0	0.8	-0.3	-0.5	-0.6	-0.3	-0.3	-0.5
Impedance of arm (left)	0.2	0.9	2.9	-1.7	-0.3	0.5	0.4	0.7	0.5	0.5	1.7
Arm fat mass (right)	6.9	28.3	43.2	-0.3	6.2	-5.8	-5.9	-6.6	-5.8	-5.8	-3.2
Trunk predicted mass	0.8	4.5	6.1	1.3	1.8	-2.4	-2.4	-2.5	-2.4	-2.4	-1.1
Standing height	0.1	0.6	3.3	0.4	-1.1	-0.2	-0.3	0.0	-0.2	-0.2	1.8
Length of working week for main job	0.7	0.8	1.8	0.5	1.4	-1.0	-0.9	-0.0	-1.0	-1.0	0.6
Exposure to tobacco smoke at home	0.7	0.7	4.3	0.9	2.1	-0.4	-0.4	-0.3	-0.4	-0.4	0.1
Breastfed as a baby	0.7	0.9	2.2	0.4	-0.4	0.7	0.9	1.4	0.7	0.7	1.5
Tense / ‘highly strung’	0.2	0.3	1.3	-1.1	-0.3	0.3	0.3	0.1	0.3	0.3	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.8	0.2	0.1	-0.1	-0.0	-0.2	-0.1	-0.1	-0.9
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.5	-0.9	-0.7	-0.7	-1.0	-0.7	-0.7	-0.0
Birth weight of first child	0.2	0.3	0.9	-0.4	-0.2	0.5	0.6	1.0	0.5	0.5	-0.7
Peak expiratory flow (PEF)	0.1	0.1	0.4	-0.6	-0.4	-0.4	-0.3	0.1	-0.4	-0.4	0.1
Pulse wave reflection index	0.2	0.3	1.7	-0.7	0.1	0.0	-0.0	-0.2	0.0	0.0	-1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	6.0	-0.1	2.5	-0.8	-1.1	-1.6	-0.8	-0.8	0.0
Loud music exposure frequency	1.1	1.2	2.1	-0.8	1.2	-1.0	-1.0	-1.1	-1.0	-1.0	-1.5
Qualifications: O levels/GCSEs or equivalent	5.2	8.3	12.2	0.6	-3.4	3.2	3.4	3.5	3.2	3.2	0.1
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	6.5	1.0	2.5	-2.2	-2.0	-1.3	-2.2	-2.2	2.2
Blood clot in the leg (DVT)	0.8	1.0	3.6	-1.9	0.1	0.9	0.4	-0.1	0.9	0.9	-1.4
Medication: Paracetamol	0.1	0.2	0.6	-0.1	-0.4	-0.1	-0.4	-0.7	-0.1	-0.1	0.8
Headache pain in last month	0.7	1.2	1.8	-0.7	-1.1	1.3	1.2	1.1	1.3	1.3	0.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.1	1.3	-0.3	1.5	1.4	2.0	1.5	1.5	1.8
Glaucoma (self-reported)	0.5	0.5	1.1	-0.4	0.8	-0.7	-0.6	-0.7	-0.7	-0.7	-1.1
Gout (self-reported)	0.7	0.9	2.3	0.0	0.1	-0.9	-1.1	-1.3	-0.9	-0.9	1.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.7	0.1	-0.1	-0.1	-0.2	-0.1	-0.1	-1.0
Medication: Amlodipine	0.2	0.3	1.3	-0.8	0.7	0.2	0.3	0.3	0.2	0.2	-1.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.6	-0.2	1.4	-1.6	-1.6	-1.6	-1.6	-1.6	-0.7
Birth weight	0.1	0.1	0.4	-0.6	0.6	-0.2	-0.2	0.4	-0.2	-0.2	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.1	1.0	0.9	-0.8	-0.7	-0.4	-0.8	-0.8	0.8
High blood pressure (siblings)	0.5	0.7	1.7	-0.5	1.2	-0.5	-0.8	-1.3	-0.5	-0.5	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.8	4.4	-0.6	-0.5	-0.2	-0.1	1.1	-0.2	-0.2	2.1
Body fat percentage	6.5	25.8	39.4	-0.3	6.0	-5.5	-5.7	-6.3	-5.5	-5.5	-2.4
Leg fat percentage (right)	4.6	16.7	27.8	-0.0	4.7	-4.4	-4.6	-5.3	-4.4	-4.4	-2.1
Arm fat-free mass (right)	1.2	6.0	8.9	1.4	2.5	-2.7	-2.8	-3.0	-2.7	-2.7	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.4	0.8	-0.7	-0.7	-0.2	-0.7	-0.7	-0.2
Comparative body size at age 10	0.1	0.2	1.0	-0.1	0.5	0.0	0.1	0.4	0.0	0.0	-1.0
Number of full brothers	0.4	0.5	1.6	0.4	1.3	-0.6	-0.3	0.8	-0.6	-0.6	0.9
Worry too long after embarrassment	0.8	1.3	2.4	1.6	-0.4	1.1	1.3	1.3	1.1	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.5	0.9	-0.4	-0.4	-0.4	-0.4	-0.4	0.5
Wheeze or whistling in the chest in last year	0.8	1.4	2.0	-0.4	1.1	-1.1	-1.3	-1.4	-1.1	-1.1	-1.4
Number of children fathered	0.1	0.1	0.2	-0.5	0.3	-0.2	-0.2	0.0	-0.2	-0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	9.5	11.1	19.6	0.6	-3.2	3.7	4.0	4.4	3.7	3.7	0.5
Age at first live birth	1.9	3.4	4.8	0.3	-1.9	2.2	2.2	2.0	2.2	2.2	0.8
Pulse wave peak to peak time	0.3	0.3	0.7	-0.8	-0.8	0.4	0.5	0.6	0.4	0.4	0.5
Health satisfaction	3.3	4.2	5.2	-2.2	1.8	-2.2	-2.3	-1.9	-2.2	-2.2	-1.3
Shortness of breath walking on level ground	0.6	0.7	2.5	-0.1	1.6	-0.7	-0.8	-0.9	-0.7	-0.7	-0.0
Qualifications: College or University degree	3.8	12.0	15.8	0.8	-2.9	4.0	3.9	3.9	4.0	4.0	3.0
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.3	-0.8	0.5	0.4	0.4	0.5	0.5	0.7
Mouth/teeth dental problems: Loose teeth	3.3	3.9	5.1	-1.7	2.3	-2.0	-2.3	-2.2	-2.0	-2.0	-1.0
Emphysema/chronic bronchitis	1.0	1.1	2.5	-1.5	-0.0	-0.7	-1.0	-1.6	-0.7	-0.7	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	0.3	0.2	1.4	1.4	1.3	1.4	1.4	0.5
Neck or shoulder pain in last month	1.7	2.5	7.0	1.3	-0.6	1.5	1.7	2.6	1.5	1.5	1.3
Medication: Blood pressure	1.5	2.7	4.3	-0.9	0.8	-1.9	-1.8	-2.1	-1.9	-1.9	-1.3
Angina (self-reported)	0.3	0.4	0.7	0.4	-0.3	0.8	0.8	0.8	0.8	0.8	-0.4
Migraine (self-reported)	0.7	0.9	1.5	-0.5	-1.2	1.1	1.1	0.8	1.1	1.1	0.4
Medication: Ibuprofen	0.2	0.3	0.5	0.0	-0.1	-0.7	-0.7	-0.5	-0.7	-0.7	-0.1
Medication: Allopurinol	1.2	1.6	3.7	-0.7	0.8	-1.3	-1.6	-1.9	-1.3	-1.3	0.4
Medication: Omeprazole	0.8	0.9	3.4	-1.3	-0.8	-0.6	-0.5	-0.6	-0.6	-0.6	-1.8
Medication: Seretide 50 evohaler	2.2	2.5	3.8	0.8	1.9	-1.7	-1.8	-1.8	-1.7	-1.7	0.4
Mean time to correctly identify matches	0.4	0.8	1.5	0.2	1.2	-0.9	-0.9	-0.9	-0.9	-0.9	-0.6
Heart disease (mother)	0.6	0.7	1.3	-0.9	-0.9	0.8	0.8	0.5	0.8	0.8	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.1	0.6	-0.8	0.9	0.7	0.8	0.9	0.9	1.8
Whole body fat mass	6.8	28.5	42.9	-0.0	6.1	-5.9	-6.0	-6.5	-5.9	-5.9	-2.6
Leg fat mass (right)	5.6	21.6	34.1	0.3	5.4	-5.1	-5.2	-5.8	-5.1	-5.1	-2.4
Arm predicted mass (right)	1.2	6.3	10.4	1.2	2.2	-2.8	-2.9	-3.2	-2.8	-2.8	-1.2
Pulse rate, automated reading	3.0	9.6	15.8	0.3	3.4	-3.5	-3.6	-4.0	-3.5	-3.5	0.0
Alcohol intake frequency.	0.3	0.7	3.5	-1.3	0.8	0.1	0.1	-0.3	0.1	0.1	-1.9
Comparative height size at age 10	0.0	0.1	1.0	0.2	0.0	-0.2	-0.3	0.0	-0.2	-0.2	1.0
Number of full sisters	0.2	0.2	0.6	0.6	-0.5	0.2	0.1	0.8	0.2	0.2	0.4
Suffer from ‘nerves’	0.3	0.5	2.3	-1.5	0.1	0.1	-0.1	-0.7	0.1	0.1	-0.8
Overall health rating	0.7	1.5	2.4	-0.4	1.5	-1.5	-1.4	-1.1	-1.5	-1.5	-0.3
Chest pain or discomfort	0.4	0.5	2.7	0.7	1.6	-0.4	-0.3	0.2	-0.4	-0.4	-0.8
Had major operations	2.3	2.7	6.2	2.5	1.2	-1.9	-1.5	-0.7	-1.9	-1.9	0.7
Age at last live birth	0.7	1.0	1.7	-0.1	0.3	1.3	1.3	0.7	1.3	1.3	-0.7
Family relationship satisfaction	4.6	5.7	8.1	-2.8	2.5	-2.5	-2.5	-2.0	-2.5	-2.5	-1.4
Leg pain on walking	0.6	0.7	1.9	-0.5	0.5	-0.6	-0.8	-1.3	-0.6	-0.6	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.1	-0.9	0.7	-1.4	-1.4	-1.3	-1.4	-1.4	-1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	6.4	0.1	-2.5	0.8	0.7	0.6	0.8	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.6	0.4	-1.9	0.4	0.3	-0.3	0.4	0.4	-1.1
Medication: Aspirin	0.6	0.8	4.5	-0.6	-0.8	0.3	0.1	-0.7	0.3	0.3	-2.1
Supplements: Vitamin C	0.5	0.6	2.2	0.4	-1.1	0.3	0.3	0.8	0.3	0.3	1.5
Knee pain experienced in last month	0.6	0.9	2.6	1.3	1.6	-0.5	-0.5	-0.1	-0.5	-0.5	1.4
Hypertension (Self-reported)	0.4	1.2	3.6	1.9	1.8	-0.8	-0.7	-0.9	-0.8	-0.8	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.2	-0.1	0.4	-0.9	-1.0	-1.2	-0.9	-0.9	-1.8
Illnesses of father: Heart disease	0.1	0.1	0.4	0.6	-0.5	-0.4	-0.2	-0.2	-0.4	-0.4	0.0
Illnesses of siblings: Diabetes	8.6	10.6	15.4	-1.9	3.8	-3.2	-3.5	-3.9	-3.2	-3.2	-2.9
Smoking status: Previous	2.7	4.0	6.6	0.8	2.1	-2.0	-2.0	-2.6	-2.0	-2.0	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.9	-0.4	-1.0	-0.3	-0.4	-0.2	-0.3	-0.3	0.6
Whole body fat-free mass	1.5	8.6	11.6	1.1	2.9	-3.4	-3.3	-3.4	-3.4	-3.4	-1.6
Leg fat-free mass (right)	2.9	15.2	19.6	0.5	4.3	-4.4	-4.4	-4.4	-4.4	-4.4	-2.4
Arm fat percentage (left)	7.5	30.0	47.8	-0.7	6.9	-5.8	-5.9	-6.5	-5.8	-5.8	-3.5
Average weekly red wine intake	0.3	0.5	0.8	-0.2	0.3	-0.7	-0.9	-0.8	-0.7	-0.7	0.8
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.9	-1.4	-1.7	1.2	1.1	0.6	1.2	1.2	-1.5
Mood swings	3.3	5.9	7.3	-2.3	2.5	-2.7	-2.7	-2.2	-2.7	-2.7	-1.3
Loneliness, isolation	0.6	0.8	3.3	1.0	1.8	-0.6	-0.4	-0.6	-0.6	-0.6	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.3	1.2	0.8	-0.9	-0.7	-0.6	-0.9	-0.9	0.2
Ever had bowel cancer screening	0.5	0.6	1.9	1.1	-0.9	0.3	0.3	0.5	0.3	0.3	1.4
Diabetes diagnosed by doctor	3.3	5.4	8.4	-0.3	2.7	-2.6	-2.6	-2.9	-2.6	-2.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.9	-2.0	1.1	-0.6	-0.6	-0.2	-0.6	-0.6	-1.0
Friendships satisfaction	0.9	1.1	6.5	0.7	0.4	0.0	0.2	1.2	0.0	0.0	2.5
Qualifications: nursing, teaching	0.9	1.3	2.2	0.9	-0.6	1.3	1.5	1.4	1.3	1.3	0.4
Commuting to job workplace: Walk	0.8	0.8	2.9	-1.7	0.3	-0.9	-0.7	-0.5	-0.9	-0.9	-0.0
Eye problems/disorders: Cataract	0.5	0.6	1.7	-0.9	-0.1	-0.8	-0.6	-0.1	-0.8	-0.8	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	0.8	-0.4	-0.4	-0.3	0.2	-0.4	-0.4	1.0
Medication for cholesterol	0.4	0.6	1.8	-0.5	-1.1	0.5	0.7	1.4	0.5	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	0.3	-1.1	0.7	0.4	0.1	0.7	0.7	0.5
Back pain experienced in last month	3.9	5.7	8.0	2.5	-1.5	2.7	2.6	2.8	2.6	2.6	1.2
Mineral and other dietary supplements	0.4	0.5	1.8	-1.4	0.6	-0.6	-0.6	-0.6	-0.6	-0.6	-0.6
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	0.5	0.3	0.3	0.2	0.3	0.3	-0.0
Asthma (self-reported)	3.3	6.5	8.9	-1.1	1.4	-3.0	-2.9	-3.0	-3.0	-3.0	-2.2
Osteoporosis (self-reported)	0.9	1.1	1.7	-0.5	-1.0	1.3	1.3	0.7	1.3	1.3	-0.8
Osteoarthritis (self-reported)	0.3	0.4	1.8	1.3	-0.5	0.4	0.3	0.2	0.4	0.4	0.5
Medication: Aspirin	0.4	0.5	3.0	-0.1	-0.7	0.2	0.1	-0.6	0.2	0.2	-1.7
Medication: Gliclazide	0.5	0.5	1.2	1.1	0.6	-0.8	-0.7	-0.6	-0.8	-0.8	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	-0.5	0.8	0.7	0.7	1.0	0.7	0.7	0.4
Smoking status: Current	1.5	2.3	3.7	0.3	1.5	-1.9	-1.8	-1.3	-1.9	-1.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	5.1	0.6	-0.7	0.6	0.6	0.6	0.6	0.6	2.3
Whole body water mass	1.5	8.8	11.6	1.1	3.0	-3.4	-3.4	-3.4	-3.4	-3.4	-1.6
Leg predicted mass (right)	2.7	14.5	18.6	0.5	4.2	-4.3	-4.3	-4.3	-4.3	-4.3	-2.3
Arm fat mass (left)	6.5	26.7	39.3	-0.1	6.3	-5.6	-5.7	-6.3	-5.6	-5.6	-3.2
Number of self-reported non-cancer illnesses	2.6	4.4	7.2	-0.5	2.0	-2.2	-2.2	-2.7	-2.2	-2.2	-2.3
Average weekly champagne plus white wine intake	0.2	0.3	1.8	-1.3	0.2	0.1	-0.3	-0.9	0.1	0.1	-0.0
Miserableness	0.2	0.4	2.3	0.3	-0.5	-0.1	0.3	1.5	-0.1	-0.1	0.7
Guilty feelings	0.1	0.2	0.6	0.2	0.8	-0.1	-0.3	-0.7	-0.1	-0.1	-0.2
Wears glasses or contact lenses	1.0	1.2	1.6	1.2	-0.5	1.3	1.2	1.0	1.3	1.3	0.7
Ever taken oral contraceptive pill	0.5	0.5	2.2	0.4	-0.9	0.5	0.3	-0.4	0.5	0.5	-1.5
Hearing aid user	1.7	1.9	9.8	3.1	0.4	0.2	0.5	1.0	0.2	0.2	2.0
Mother’s age at death	4.9	6.2	8.3	1.8	-2.7	2.8	2.9	2.5	2.8	2.8	1.0
Financial situation satisfaction	6.2	7.7	11.3	-2.8	3.4	-2.8	-2.6	-2.1	-2.8	-2.8	-2.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.0	0.2	2.0	-1.1	-1.2	-0.8	-1.1	-1.1	0.5
Commuting to job workplace: Public transport	0.3	0.4	0.8	0.8	0.9	0.6	0.6	0.4	0.6	0.6	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.9	0.5	-0.2	-0.3	-0.3	-0.2	-0.2	-0.9
Medication: Blood pressure	0.4	0.8	5.2	0.6	2.3	-0.0	-0.1	-0.6	-0.0	-0.0	-0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.8	3.8	0.6	1.9	-0.6	-0.8	-0.7	-0.6	-0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	2.8	1.7	-0.2	0.2	0.2	0.0	0.2	0.2	0.8
High cholesterol (Self-reported)	0.8	1.3	6.0	-1.2	-0.2	-0.6	-0.7	-1.3	-0.6	-0.6	-2.4
Medication: Bendroflumethiazide	0.2	0.3	1.7	1.3	0.4	0.4	0.4	-0.0	0.4	0.4	-0.3
Medication: Paracetamol	0.4	0.6	2.4	1.0	-0.5	-0.3	-0.5	-0.4	-0.3	-0.3	1.5
Medication: Lisinopril	0.5	0.6	1.5	-0.5	-0.0	-0.8	-0.9	-1.2	-0.8	-0.8	-0.7
Medication: Atorvastatin	0.9	1.1	2.3	-0.6	1.1	-1.0	-1.3	-1.5	-1.0	-1.0	-0.6
Illnesses of father: High blood pressure	1.6	2.0	2.9	-0.9	0.7	-1.6	-1.6	-1.7	-1.6	-1.6	-1.2
Alcohol drinker status: Never	0.3	0.3	1.5	-0.6	1.2	0.1	-0.1	-0.5	0.1	0.1	0.5
Ever smoked	2.2	3.8	5.1	2.0	2.3	-2.0	-1.9	-2.0	-2.0	-2.0	-1.0
Basal metabolic rate	2.3	12.7	17.5	0.8	3.7	-4.0	-4.0	-4.2	-4.0	-4.0	-2.0
Leg fat percentage (left)	4.5	16.5	27.5	-0.2	4.6	-4.3	-4.5	-5.2	-4.3	-4.3	-2.5
Arm fat-free mass (left)	1.3	6.8	10.6	1.3	2.6	-2.9	-3.0	-3.3	-2.9	-2.9	-1.2
Number of operations (self-reported)	1.3	1.9	4.0	1.0	2.0	-1.6	-1.3	-0.8	-1.6	-1.6	-0.1
Average weekly beer plus cider intake	3.6	5.3	7.7	-0.8	2.1	-2.8	-2.8	-2.5	-2.8	-2.8	-0.1
Irritability	1.6	2.7	3.2	-1.8	1.4	-1.7	-1.6	-1.5	-1.7	-1.7	-1.5
Risk taking	0.8	1.1	3.4	1.2	1.8	-1.1	-0.8	-0.4	-1.0	-1.0	0.4
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.3	-0.7	0.1	-1.4	-1.5	-1.1	-1.4	-1.4	0.3
Fractured/broken bones in last 5 years	0.3	0.3	1.6	0.9	0.5	-0.1	0.1	-0.1	-0.1	-0.1	-1.3
Age started oral contraceptive pill	1.0	1.3	1.9	0.7	0.7	1.4	1.2	1.1	1.4	1.4	0.9
Diastolic blood pressure, automated reading	0.3	1.0	3.5	1.9	0.6	-0.7	-0.7	-1.2	-0.7	-0.7	1.0
Ever depressed for a whole week	0.3	0.3	0.9	0.4	1.0	0.6	0.6	0.2	0.6	0.6	-0.5
Unable to work because of sickness or disability	0.2	0.2	1.2	0.0	1.1	0.3	0.3	0.2	0.3	0.3	-0.5
Commuting to job workplace: Cycle	0.4	0.5	2.7	-1.2	0.1	-0.0	0.1	0.3	-0.0	-0.0	-1.6
Myopia	0.2	0.3	0.9	0.8	1.0	-0.5	-0.3	0.4	-0.5	-0.5	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.4	2.2	-1.5	-0.7	-0.0	-0.1	0.3	-0.0	-0.0	-0.1
Cholesterol lowering medication	0.3	0.4	1.7	0.0	0.6	0.1	-0.1	-0.9	0.1	0.1	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.9	-2.4	0.1	-1.2	-1.1	-0.8	-1.2	-1.2	-2.1
Pain experienced in last month	0.1	0.1	0.3	0.6	-0.0	0.3	0.3	-0.4	0.3	0.3	-0.2
Supplements: Calcium	4.0	4.4	6.2	1.3	-2.4	2.1	2.2	2.5	2.1	2.1	1.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.8	-1.0	-0.1	-0.0	-0.1	-0.1	-0.1	-1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.9	-0.5	0.7	0.5	-0.1	0.7	0.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	4.5	-2.1	0.2	0.9	0.4	-0.3	0.9	0.9	-1.5
Heart disease (siblings)	0.4	0.5	3.1	-0.6	-0.8	-0.1	0.0	0.1	-0.1	-0.1	-1.7
Alcohol drinker status: Previous	0.0	0.1	0.3	-0.2	-0.1	0.1	0.2	-0.1	0.1	0.1	-0.5
Pack years of smoking	0.9	1.3	5.6	2.4	1.3	-0.9	-0.6	-0.2	-0.9	-0.9	0.5
Impedance of whole body	0.6	3.0	5.6	-1.6	-1.9	1.6	1.3	1.6	1.6	1.6	2.4
Leg fat mass (left)	5.6	21.7	34.7	0.0	5.3	-5.1	-5.2	-5.9	-5.1	-5.1	-2.6
Arm predicted mass (left)	1.4	7.0	11.6	1.0	2.5	-2.9	-3.0	-3.4	-2.9	-2.9	-1.4