Hub : Genes

DHFRL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0760 0.0440 4.1e-03 0.005 0.016 0.004 0.017 0.010 6.9e-02 4.2e-03 8.8e-02 3.0e-03 1.8e-02
2 YFS Blood 0.0717 0.0319 2.1e-10 0.042 0.031 0.040 0.035 0.044 1.0e-13 1.6e-10 5.7e-13 1.7e-11 4.1e-14
3 TCGA Breast Invasive Carcinoma 0.0730 0.0315 1.2e-08 0.054 0.038 0.052 NA 0.054 3.3e-11 2.5e-08 6.5e-11 NA 3.4e-11
4 TCGA Glioblastoma Multiforme 0.1950 0.1010 6.8e-03 0.116 0.089 0.076 NA 0.108 2.3e-04 1.2e-03 2.5e-03 NA 3.7e-04
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0728 0.0361 2.3e-05 0.046 0.038 0.050 NA 0.040 6.8e-06 3.7e-05 2.5e-06 NA 2.2e-05
6 TCGA Kidney Renal Clear Cell Carcinoma 0.1289 0.0665 9.6e-06 0.069 0.054 0.065 NA 0.067 3.2e-08 1.1e-06 8.3e-08 NA 5.7e-08
7 TCGA Brain Lower Grade Glioma 0.1009 0.0433 5.1e-06 0.058 0.035 0.042 NA 0.046 3.7e-07 6.5e-05 1.3e-05 NA 5.2e-06
8 TCGA Skin Cutaneous Melanoma 0.1320 0.0740 7.0e-03 0.016 0.062 0.043 NA 0.036 1.2e-01 9.7e-03 2.7e-02 NA 3.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.2 1.9 3.5 -0.5 1.9 -1.4 -1.4 -1.6 -1.4 -1.4 -1.0
Bipolar Disorder or Schizophrenia 0.2 0.4 1.1 1.0 0.9 0.2 0.1 -0.5 0.2 0.2 1.0
Depressed Affect (Nagel 2018) 0.5 1.2 1.5 -0.7 1.1 -1.2 -1.2 -1.0 -1.2 -1.2 -0.6
Depression (Nagel 2018) 0.1 0.2 1.3 -1.2 -0.4 0.1 0.2 0.4 0.1 0.1 -0.0
Intelligence (Savage-Jansen 2018) 5.3 16.4 26.5 2.0 -2.6 4.7 5.0 5.2 4.7 4.7 1.3
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -0.6 0.8 -0.7 -0.8 -1.0 -0.7 -0.7 -0.6
Schizophrenia (2018) 0.9 2.0 4.7 1.7 -0.4 1.4 1.3 0.6 1.4 1.4 2.2
Schizophrenia vs Biploar Disorder 3.7 4.9 5.8 1.3 -2.3 2.4 2.2 2.2 2.4 2.4 2.4
Worry (Nagel 2018) 0.3 0.5 1.3 -1.1 -1.1 0.7 0.6 0.1 0.7 0.7 -0.1
Alzheimer’s Disease (in mother) 0.2 0.2 1.6 -0.2 1.3 0.0 0.1 0.4 0.0 0.0 0.2
Alzheimer’s Disease (in father) 3.2 3.5 4.5 1.2 -2.1 2.0 2.1 2.0 2.0 2.0 1.0
Alzheimer’s Disease (including proxy) 1.1 1.6 3.4 0.7 -0.8 1.3 1.4 1.9 1.3 1.3 0.9
Crohns Disease (2017) 0.2 0.4 1.5 -1.2 0.1 -0.3 -0.3 -0.2 -0.3 -0.3 -1.2
Irritable Bowel Disease (IBD) 1.4 3.3 4.2 -2.0 1.3 -2.0 -1.8 -1.1 -2.0 -2.0 -2.0
Ulcerative Colitis (UC) 1.5 2.8 4.0 -1.9 1.0 -1.9 -1.7 -0.8 -1.9 -1.9 -2.0
Major Depression (MDD) 1.4 1.7 6.0 -1.8 2.4 -0.4 -0.3 -0.5 -0.4 -0.4 -1.9
Reaction Time 0.5 0.9 1.2 -0.6 1.1 -1.0 -1.1 -0.9 -1.0 -1.0 -1.1
Verbal and Numeric Reasoning (VNR) 3.0 7.2 10.8 0.2 -1.9 3.3 3.3 3.2 3.3 3.3 1.2
Breast Cancer 0.2 0.6 1.0 -0.9 0.1 -0.8 -1.0 -1.0 -0.8 -0.8 -0.3
Ovarian Cancer 1.5 2.0 2.4 1.5 -1.2 1.6 1.4 1.0 1.6 1.6 1.4
Prostate Cancer 0.8 1.1 4.5 0.3 -2.1 0.8 0.8 1.1 0.8 0.8 0.5
Age at First Birth 2.7 3.9 6.3 1.4 -2.5 1.9 2.0 2.4 1.9 1.9 1.8
Bipolar Disorder (2011) 1.3 1.2 6.5 -1.2 2.5 0.0 0.0 0.0 -1.4 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.6 0.9 1.1 -0.7 -0.7 -1.3 -0.7 -0.7 -0.5
Coronary Artery Disease (CAD) 0.2 0.3 1.5 0.2 0.7 0.3 0.1 0.1 0.3 0.3 1.2
Crohns Disease (2012) 0.1 0.2 0.9 0.1 1.0 -0.1 0.0 0.5 -0.1 -0.1 0.6
Mean Putamen Volume 0.3 0.4 1.7 1.0 0.1 -0.0 0.4 1.3 -0.0 -0.0 -0.3
Fasting Glucose 0.8 1.0 3.3 1.1 1.1 -0.7 -0.9 -1.8 -0.7 -0.7 -0.2
HbA1C 1.0 1.2 2.1 -0.7 0.2 -1.2 -1.2 -1.5 -1.2 -1.2 -0.9
HDL Cholesterol 1.3 2.2 3.0 -1.7 -0.2 -1.5 -1.7 -1.7 -1.5 -1.5 -1.4
LDL Cholesterol 0.2 0.3 0.6 -0.4 0.7 -0.6 -0.3 0.4 -0.6 -0.6 -0.8
Lupus 0.1 0.2 0.7 -0.5 -0.8 -0.1 -0.2 -0.2 -0.1 -0.1 0.5
Neuroticism (2016) 0.2 0.2 1.3 -0.4 1.1 0.1 0.0 0.6 0.1 0.1 -0.3
Primary Biliary Cirrhosis 0.8 1.2 2.5 -0.6 0.5 -1.1 -1.2 -1.2 -1.1 -1.1 -1.6
Rheumatoid Arthritis 0.4 0.6 1.2 0.3 -1.0 0.7 1.0 0.5 0.7 0.7 -1.1
Schizophrenia (2014) 1.2 2.7 4.2 1.3 -0.5 1.9 1.7 1.1 1.9 1.9 2.1
Triglycerides 0.2 0.4 2.9 -0.3 1.7 0.2 0.1 -0.2 0.2 0.2 0.1
Type 2 Diabetes (T2D) (2012) 2.3 2.6 3.8 1.2 1.3 -2.0 -1.7 -1.8 -2.0 -2.0 -0.3
Ulcerative Colitis 2.0 2.9 3.9 -1.7 1.6 -2.0 -1.9 -1.1 -2.0 -2.0 -1.2
Blood Eosinophil Count 0.3 2.7 10.0 0.7 3.2 -1.5 -1.3 -1.1 -1.5 -1.5 -0.8
Blood Platelet Count 0.1 1.3 3.9 2.0 0.0 0.5 1.0 2.0 0.5 0.5 0.7
Blood Red Count 0.2 1.7 3.0 -0.6 -0.0 1.7 1.6 0.9 1.7 1.7 -0.9
Blood White Count 0.2 1.6 8.4 1.2 2.9 -0.9 -0.6 0.0 -0.9 -0.9 -0.3
Heel T-Score 0.3 2.4 3.3 1.8 -0.8 -1.7 -1.5 -1.6 -1.7 -1.7 1.3
BMI 6.8 39.6 62.7 -0.5 7.2 -6.8 -6.9 -7.9 -6.8 -6.8 -4.1
Height 0.0 0.7 4.4 0.7 -0.0 0.2 -0.1 -0.4 0.2 0.2 2.1
Waist Hip Ratio (WHR) 0.1 0.3 1.5 0.1 1.2 0.1 -0.3 -0.5 0.1 0.1 0.6
Systolic Blood Pressure 0.1 0.7 2.8 1.0 -1.7 0.2 0.4 0.4 0.2 0.2 1.2
Smoking Status 3.5 8.5 11.8 0.5 3.4 -3.4 -3.3 -2.8 -3.4 -3.4 -1.5
Allergy or Eczema 0.2 0.5 1.5 -0.2 0.9 -0.7 -0.8 -1.2 -0.7 -0.7 -0.3
Cardiovascular Disease 0.7 2.2 4.3 0.5 1.6 -1.4 -1.5 -2.1 -1.4 -1.4 -1.3
Hypothyroidism (self reported) 0.2 0.4 1.8 -1.3 0.2 -0.0 -0.0 -0.1 -0.0 -0.0 -1.2
Respiratory disease 1.7 3.9 8.0 -0.8 1.7 -1.9 -2.1 -2.8 -1.9 -1.9 -2.1
Type 2 Diabetes (T2D) (2018) 3.9 7.2 11.6 -1.1 3.4 -2.9 -3.0 -3.1 -2.9 -2.9 -1.2
Lung FEV1/FVC ratio 1.8 9.3 14.5 -2.0 2.5 -3.1 -3.2 -3.8 -3.1 -3.1 -3.1
Lung FVC 0.1 0.8 3.5 0.5 -0.7 -0.1 0.2 1.3 -0.1 -0.1 1.9
Neuroticism 0.6 1.4 1.9 -1.3 1.4 -1.1 -1.3 -1.4 -1.1 -1.1 -0.5
Chronotype (morning person) 0.1 0.2 1.0 -1.0 -0.2 0.1 0.0 -0.3 0.1 0.1 -0.8
Hair Pigment 0.0 0.9 1.8 -0.1 0.1 -1.3 -1.2 -0.7 -1.3 -1.3 -0.3
Tanning 0.2 2.7 10.0 3.2 0.8 -1.4 -1.0 0.1 -1.4 -1.4 2.0
Hand grip strength (left) 0.2 0.5 1.6 -0.4 -1.0 0.3 0.4 1.0 0.3 0.3 1.3
Number of treatments/medications taken 1.7 3.0 6.4 -0.6 1.1 -1.6 -1.7 -2.5 -1.6 -1.6 -2.4
Average weekly spirits intake 4.2 5.2 7.2 -0.4 2.6 -2.7 -2.4 -2.2 -2.7 -2.7 -1.3
Sensitivity / hurt feelings 0.2 0.4 1.7 -0.6 1.3 -0.2 -0.3 -0.7 -0.2 -0.2 -0.5
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.7 -0.8 0.4 -0.3 -0.1 0.8 -0.3 -0.3 0.1
Hearing difficulty/problems: Yes 0.5 0.8 4.0 2.0 0.9 0.2 0.5 0.9 0.2 0.2 0.4
Relative age of first facial hair 0.1 0.3 1.2 -1.1 0.8 -0.0 -0.3 -0.6 -0.0 -0.0 -0.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.5 0.2 -0.2 -0.1 0.3 -0.2 -0.2 -0.3
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.7 1.3 -0.6 0.0 -0.1 -0.9 0.0 0.0 -1.0
Ever had hysterectomy (womb removed) 0.5 0.5 0.7 0.0 0.6 -0.9 -0.7 -0.6 -0.9 -0.9 -0.7
Systolic blood pressure, automated reading 0.2 0.7 1.6 1.1 -0.2 -0.8 -0.7 -0.8 -0.8 -0.8 1.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 3.0 0.2 1.7 -0.2 -0.4 -1.1 -0.2 -0.2 -0.9
Angina 0.7 1.0 1.6 0.4 -0.5 1.2 1.3 1.1 1.2 1.2 -0.3
Medication for hormone replacement therapy 0.3 0.3 0.5 0.7 -0.7 -0.4 -0.4 -0.7 -0.4 -0.4 -0.6
Vitamin and mineral supplements 0.4 0.5 1.4 -1.2 1.0 0.1 -0.0 -0.3 0.1 0.1 -1.2
Supplements: Zinc 0.2 0.2 0.7 0.4 -0.5 0.4 0.5 0.9 0.4 0.4 0.2
Medication: Co-codamol 0.9 1.1 4.5 0.7 2.1 -0.8 -0.9 -0.7 -0.8 -0.8 0.7
Medication: Metformin 5.6 7.9 11.9 -0.3 2.9 -3.2 -3.2 -3.5 -3.2 -3.2 -0.9
Diabetes (father) 0.1 0.1 0.2 -0.3 -0.3 -0.3 -0.2 -0.5 -0.3 -0.3 -0.2
Diabetes (mother) 1.6 2.0 5.0 1.0 2.2 -1.2 -1.4 -1.8 -1.2 -1.2 -0.8
Severe depression (siblings) 0.3 0.4 0.5 0.5 -0.2 0.7 0.7 0.5 0.7 0.7 0.7
Pack years adult smoking proportion 1.1 1.7 5.2 2.3 1.6 -1.3 -0.8 -0.3 -1.3 -1.3 -0.0
Impedance of leg (right) 1.6 7.9 13.9 -0.3 -3.7 2.8 2.6 2.7 2.8 2.8 3.4
Leg fat-free mass (left) 2.9 15.4 20.4 0.6 4.5 -4.4 -4.4 -4.5 -4.4 -4.4 -2.2
Trunk fat percentage 6.6 26.4 39.3 -0.3 6.0 -5.7 -5.8 -6.3 -5.7 -5.7 -2.1
Hand grip strength (right) 0.3 0.9 2.4 -1.3 -1.5 0.5 0.5 1.2 0.5 0.5 0.5
Townsend deprivation index at recruitment 2.6 3.7 5.4 -0.7 1.9 -2.0 -2.0 -1.9 -2.0 -2.0 -2.3
Current tobacco smoking 1.3 2.2 3.5 0.4 1.5 -1.9 -1.8 -1.2 -1.9 -1.9 -0.2
Average weekly fortified wine intake 0.2 0.3 0.6 -0.8 -0.7 -0.6 -0.5 -0.2 -0.6 -0.6 -0.0
Maternal smoking around birth 3.1 4.5 8.2 -0.4 2.0 -2.4 -2.5 -2.9 -2.4 -2.4 -0.9
Fed-up feelings 2.2 3.9 5.4 -2.2 2.0 -2.1 -2.3 -2.1 -2.1 -2.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.9 -0.4 -0.9 0.7 0.9 1.7 0.7 0.7 -0.3
Relative age voice broke 0.3 0.5 2.0 -1.4 -1.1 -0.0 -0.2 -0.6 -0.0 -0.0 0.4
Taking other prescription medications 1.0 1.6 2.2 0.5 1.4 -1.5 -1.4 -1.3 -1.5 -1.5 -0.3
Age when periods started (menarche) 0.1 0.3 1.0 -1.0 0.0 -0.6 -0.6 -0.3 -0.6 -0.6 0.4
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 5.3 0.6 2.3 -1.7 -1.4 -1.2 -1.7 -1.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 3.0 0.7 -0.1 -1.7 -1.6 -1.6 -1.7 -1.7 0.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 1.1 0.3 -1.5 -1.2 -0.6 -1.5 -1.5 0.3
Qualifications: CSEs or equivalent 0.5 0.7 2.0 1.4 -1.1 0.2 0.5 1.1 0.2 0.2 0.7
Serious illness, injury or assault to yourself 0.6 0.7 1.1 0.0 0.7 -1.1 -0.8 -0.3 -1.1 -1.1 0.8
High blood pressure 0.2 0.5 2.3 1.5 1.2 -0.3 -0.1 -0.3 -0.3 -0.3 0.1
Hayfever, allergic rhinitis or eczema 1.0 2.1 4.3 -0.9 1.8 -1.4 -1.5 -2.1 -1.4 -1.4 -0.9
Multivitamins +/- minerals 0.3 0.4 1.3 1.0 -1.1 0.3 0.2 0.1 0.3 0.3 0.8
Stomach or abdominal pain in last month 0.2 0.3 1.6 -0.1 -0.6 0.2 0.4 1.2 0.2 0.2 0.0
Supplements: Glucosamine 1.2 1.6 4.1 2.0 -1.5 1.1 1.0 0.8 1.1 1.1 0.8
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.6 -0.3 0.2 -0.3 -0.2 0.3 -0.3 -0.3 0.7
Medication: Atenolol 0.6 0.8 3.6 -0.4 1.9 -0.3 -0.5 -1.2 -0.3 -0.3 -0.7
Medication: Levothyroxine sodium 0.0 0.1 0.2 -0.1 0.1 -0.3 -0.0 0.5 -0.3 -0.3 0.1
Sitting height 0.4 2.8 4.7 -0.8 0.7 -2.0 -2.2 -1.9 -2.0 -2.0 -0.5
Chronic bronchitis/emphysema (father) 0.3 0.3 1.6 1.3 0.4 -0.3 -0.3 -0.2 -0.3 -0.3 0.5
High blood pressure (mother) 0.2 0.3 0.7 0.1 -0.8 0.3 0.1 -0.8 0.3 0.3 -0.7
Body mass index (BMI) 5.4 23.1 34.6 0.2 5.6 -5.1 -5.2 -5.9 -5.1 -5.1 -3.5
Impedance of leg (left) 1.4 7.0 13.0 -0.7 -3.6 2.7 2.4 2.6 2.7 2.7 2.9
Leg predicted mass (left) 3.0 15.7 20.3 0.5 4.5 -4.5 -4.5 -4.5 -4.5 -4.5 -2.1
Trunk fat mass 6.2 26.7 39.6 -0.1 5.9 -5.8 -5.8 -6.3 -5.8 -5.8 -2.4
Waist circumference 4.8 17.7 30.5 -0.2 5.5 -4.3 -4.5 -5.2 -4.3 -4.3 -2.9
Number of incorrect matches in round 0.4 0.6 2.2 -0.2 1.5 -0.7 -0.6 -0.5 -0.7 -0.7 -0.8
Past tobacco smoking 3.0 5.6 7.8 -1.8 -2.5 2.5 2.5 2.8 2.5 2.5 1.7
Alcohol usually taken with meals 0.6 0.9 1.6 1.2 -0.9 0.8 0.7 0.9 0.8 0.8 1.3
Nervous feelings 0.8 1.5 2.8 -0.6 -1.7 1.5 1.3 0.7 1.5 1.5 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.4 -0.6 -0.0 0.9 1.0 1.2 0.9 0.9 -0.7
Hearing difficulty/problems with background noise 0.3 0.4 2.1 0.2 0.4 0.1 0.5 0.9 0.1 0.1 -1.4
Hair/balding pattern: Pattern 2 0.5 0.6 0.7 -0.2 -0.8 0.9 0.8 0.8 0.9 0.9 0.7
Had menopause 1.6 2.0 3.1 1.4 -0.4 1.8 1.6 0.9 1.8 1.8 1.0
Had other major operations 1.3 1.6 3.5 -0.3 1.9 -1.5 -1.4 -0.8 -1.5 -1.5 0.2
Forced vital capacity (FVC) 0.4 1.4 5.9 0.1 -1.3 0.4 0.5 1.7 0.4 0.4 2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 1.8 0.8 -0.9 -1.4 -1.3 -1.3 -1.4 -1.4 1.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.4 0.4 1.2 0.5 0.6 0.3 0.5 0.5 -0.2
Qualifications: None of the above 1.9 4.1 7.8 1.8 2.2 -2.0 -2.1 -2.8 -2.0 -2.0 0.3
Financial difficulties in last 2 years 0.3 0.4 0.7 -0.1 0.8 -0.8 -0.5 0.0 -0.8 -0.8 -0.2
Mouth/teeth dental problems 0.4 0.7 0.9 -0.5 -0.9 0.9 1.0 1.0 0.9 0.9 -0.4
Heart attack 0.3 0.4 1.2 1.1 -0.6 0.6 0.3 -0.3 0.6 0.6 -0.4
Allergy 3.3 7.6 12.7 2.3 -2.6 2.7 3.0 3.6 2.7 2.7 2.1
Pain all over the body in last month 1.3 1.4 4.4 -0.4 -0.2 -1.1 -1.4 -2.1 -1.1 -1.1 -1.0
Diabetes (self-reported) 2.6 4.0 7.3 0.1 2.7 -2.2 -2.1 -2.5 -2.2 -2.2 -0.7
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 4.6 -1.1 2.0 -2.2 -2.0 -1.9 -2.2 -2.2 -0.9
Medication: Ramipril 0.0 0.1 0.1 0.4 0.2 0.1 0.2 0.4 0.1 0.1 0.3
Medication: Simvastatin 1.8 2.7 14.0 -1.2 0.6 -0.7 -0.7 -1.9 -0.7 -0.7 -3.7
Fluid intelligence score 3.2 6.6 10.9 0.0 -1.8 3.0 3.3 3.2 3.0 3.0 0.2
Illnesses of siblings 0.9 1.3 2.5 0.2 -1.6 1.2 1.3 1.2 1.2 1.2 1.0
Neuroticism score 0.1 0.3 0.8 -0.9 0.8 -0.1 -0.2 -0.3 -0.1 -0.1 -0.7
Weight 4.3 21.2 31.8 0.2 5.1 -5.1 -5.2 -5.6 -5.1 -5.1 -2.6
Impedance of arm (right) 0.1 0.6 2.1 -1.4 -0.5 0.4 0.2 0.6 0.4 0.4 1.4
Arm fat percentage (right) 7.6 30.1 46.1 -0.5 6.8 -5.9 -5.9 -6.5 -5.9 -5.9 -3.5
Trunk fat-free mass 0.8 4.7 6.3 1.3 1.8 -2.5 -2.4 -2.5 -2.5 -2.5 -1.2
Hip circumference 3.4 14.5 22.0 -0.5 4.7 -4.0 -4.0 -4.5 -4.0 -4.0 -3.1
Time employed in main current job 0.3 0.4 1.9 -1.4 0.3 0.4 0.4 0.5 0.4 0.4 -0.2
Alcohol intake versus 10 years previously 0.5 0.8 3.8 0.5 1.3 -0.2 -0.3 -0.4 -0.3 -0.3 -2.0
Father’s age at death 0.8 1.1 4.3 -0.6 -2.1 0.7 0.8 1.1 0.7 0.7 0.9
Worrier / anxious feelings 0.5 1.0 1.5 -0.1 -0.8 1.1 1.1 1.2 1.1 1.1 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.1 0.9 -0.3 0.9 0.9 1.5 0.9 0.9 0.7
Falls in the last year 0.3 0.5 0.7 -0.9 0.6 -0.6 -0.7 -0.8 -0.6 -0.6 -0.6
Hair/balding pattern: Pattern 3 0.4 0.6 3.0 -1.7 0.7 0.3 0.2 0.4 0.3 0.3 -1.0
Number of live births 0.1 0.1 0.4 -0.1 0.5 -0.1 -0.0 -0.1 -0.1 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 3.1 -0.8 -1.3 0.1 0.2 1.0 0.1 0.1 1.8
Pulse rate 2.5 4.2 7.1 0.9 2.7 -2.2 -2.3 -2.4 -2.2 -2.2 0.4
Happiness 1.6 1.9 4.0 -0.6 2.0 -1.6 -1.5 -1.2 -1.6 -1.6 -0.3
Noisy workplace 0.7 0.9 3.9 2.0 0.7 -0.8 -0.7 -0.2 -0.8 -0.8 0.7
Qualifications: A levels/AS levels or equivalent 2.4 5.2 8.1 -2.5 -2.8 2.2 2.4 2.8 2.2 2.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.3 0.4 -0.9 1.1 1.2 1.5 1.1 1.1 1.0
Mouth/teeth dental problems: Dentures 0.8 1.4 2.5 0.3 -0.9 1.6 1.4 0.5 1.6 1.6 -0.6
Asthma 3.9 7.7 10.2 -1.5 1.5 -3.2 -3.1 -3.2 -3.2 -3.2 -2.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.1 -0.1 -0.8 -0.8 -0.7 -0.8 -0.8 -0.3
Medication: Cholesterol lowering 1.2 1.8 9.6 -1.6 -0.3 -0.2 -0.4 -1.4 -0.2 -0.2 -3.1
Depression (self-reported) 0.9 1.0 2.5 -1.6 1.5 -0.7 -0.9 -1.0 -0.7 -0.7 -0.4
Medication: Lansoprazole 0.3 0.3 2.0 1.4 -0.0 0.2 0.1 0.0 0.2 0.2 -0.7
Prospective memory result 2.6 3.2 6.3 -0.1 2.5 -1.9 -2.0 -2.2 -1.9 -1.9 -0.2
Lung cancer (father) 1.7 2.0 3.2 -0.9 1.7 -1.8 -1.6 -0.6 -1.8 -1.8 -0.2
Illnesses of mother 0.2 0.3 0.4 -0.4 0.2 -0.7 -0.3 0.6 -0.7 -0.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.5 -1.2 -0.5 -0.6 -0.6 0.1 -0.6 -0.6 1.2
Pulse wave Arterial Stiffness index 0.3 0.3 0.9 1.0 0.8 -0.3 -0.5 -0.6 -0.3 -0.3 -0.5
Impedance of arm (left) 0.2 0.9 2.9 -1.7 -0.3 0.5 0.4 0.7 0.5 0.5 1.7
Arm fat mass (right) 6.9 28.3 43.2 -0.3 6.2 -5.8 -5.9 -6.6 -5.8 -5.8 -3.2
Trunk predicted mass 0.8 4.5 6.1 1.3 1.8 -2.4 -2.4 -2.5 -2.4 -2.4 -1.1
Standing height 0.1 0.6 3.3 0.4 -1.1 -0.2 -0.3 0.0 -0.2 -0.2 1.8
Length of working week for main job 0.7 0.8 1.8 0.5 1.4 -1.0 -0.9 -0.0 -1.0 -1.0 0.6
Exposure to tobacco smoke at home 0.7 0.7 4.3 0.9 2.1 -0.4 -0.4 -0.3 -0.4 -0.4 0.1
Breastfed as a baby 0.7 0.9 2.2 0.4 -0.4 0.7 0.9 1.4 0.7 0.7 1.5
Tense / ‘highly strung’ 0.2 0.3 1.3 -1.1 -0.3 0.3 0.3 0.1 0.3 0.3 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.8 0.2 0.1 -0.1 -0.0 -0.2 -0.1 -0.1 -0.9
Hair/balding pattern: Pattern 4 0.2 0.5 1.1 0.5 -0.9 -0.7 -0.7 -1.0 -0.7 -0.7 -0.0
Birth weight of first child 0.2 0.3 0.9 -0.4 -0.2 0.5 0.6 1.0 0.5 0.5 -0.7
Peak expiratory flow (PEF) 0.1 0.1 0.4 -0.6 -0.4 -0.4 -0.3 0.1 -0.4 -0.4 0.1
Pulse wave reflection index 0.2 0.3 1.7 -0.7 0.1 0.0 -0.0 -0.2 0.0 0.0 -1.3
Ever highly irritable/argumentative for 2 days 1.2 1.4 6.0 -0.1 2.5 -0.8 -1.1 -1.6 -0.8 -0.8 0.0
Loud music exposure frequency 1.1 1.2 2.1 -0.8 1.2 -1.0 -1.0 -1.1 -1.0 -1.0 -1.5
Qualifications: O levels/GCSEs or equivalent 5.2 8.3 12.2 0.6 -3.4 3.2 3.4 3.5 3.2 3.2 0.1
Mouth/teeth dental problems: Bleeding gums 3.2 4.1 6.5 1.0 2.5 -2.2 -2.0 -1.3 -2.2 -2.2 2.2
Blood clot in the leg (DVT) 0.8 1.0 3.6 -1.9 0.1 0.9 0.4 -0.1 0.9 0.9 -1.4
Medication: Paracetamol 0.1 0.2 0.6 -0.1 -0.4 -0.1 -0.4 -0.7 -0.1 -0.1 0.8
Headache pain in last month 0.7 1.2 1.8 -0.7 -1.1 1.3 1.2 1.1 1.3 1.3 0.4
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 4.1 1.3 -0.3 1.5 1.4 2.0 1.5 1.5 1.8
Glaucoma (self-reported) 0.5 0.5 1.1 -0.4 0.8 -0.7 -0.6 -0.7 -0.7 -0.7 -1.1
Gout (self-reported) 0.7 0.9 2.3 0.0 0.1 -0.9 -1.1 -1.3 -0.9 -0.9 1.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.9 -0.7 0.1 -0.1 -0.1 -0.2 -0.1 -0.1 -1.0
Medication: Amlodipine 0.2 0.3 1.3 -0.8 0.7 0.2 0.3 0.3 0.2 0.2 -1.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 2.6 -0.2 1.4 -1.6 -1.6 -1.6 -1.6 -1.6 -0.7
Birth weight 0.1 0.1 0.4 -0.6 0.6 -0.2 -0.2 0.4 -0.2 -0.2 -0.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.1 1.0 0.9 -0.8 -0.7 -0.4 -0.8 -0.8 0.8
High blood pressure (siblings) 0.5 0.7 1.7 -0.5 1.2 -0.5 -0.8 -1.3 -0.5 -0.5 -1.0
Forced vital capacity (FVC), Best measure 0.2 0.8 4.4 -0.6 -0.5 -0.2 -0.1 1.1 -0.2 -0.2 2.1
Body fat percentage 6.5 25.8 39.4 -0.3 6.0 -5.5 -5.7 -6.3 -5.5 -5.5 -2.4
Leg fat percentage (right) 4.6 16.7 27.8 -0.0 4.7 -4.4 -4.6 -5.3 -4.4 -4.4 -2.1
Arm fat-free mass (right) 1.2 6.0 8.9 1.4 2.5 -2.7 -2.8 -3.0 -2.7 -2.7 -1.0
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.4 0.8 -0.7 -0.7 -0.2 -0.7 -0.7 -0.2
Comparative body size at age 10 0.1 0.2 1.0 -0.1 0.5 0.0 0.1 0.4 0.0 0.0 -1.0
Number of full brothers 0.4 0.5 1.6 0.4 1.3 -0.6 -0.3 0.8 -0.6 -0.6 0.9
Worry too long after embarrassment 0.8 1.3 2.4 1.6 -0.4 1.1 1.3 1.3 1.1 1.1 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 0.5 0.9 -0.4 -0.4 -0.4 -0.4 -0.4 0.5
Wheeze or whistling in the chest in last year 0.8 1.4 2.0 -0.4 1.1 -1.1 -1.3 -1.4 -1.1 -1.1 -1.4
Number of children fathered 0.1 0.1 0.2 -0.5 0.3 -0.2 -0.2 0.0 -0.2 -0.2 0.4
Reason for reducing amount of alcohol drunk: Health precaution 9.5 11.1 19.6 0.6 -3.2 3.7 4.0 4.4 3.7 3.7 0.5
Age at first live birth 1.9 3.4 4.8 0.3 -1.9 2.2 2.2 2.0 2.2 2.2 0.8
Pulse wave peak to peak time 0.3 0.3 0.7 -0.8 -0.8 0.4 0.5 0.6 0.4 0.4 0.5
Health satisfaction 3.3 4.2 5.2 -2.2 1.8 -2.2 -2.3 -1.9 -2.2 -2.2 -1.3
Shortness of breath walking on level ground 0.6 0.7 2.5 -0.1 1.6 -0.7 -0.8 -0.9 -0.7 -0.7 -0.0
Qualifications: College or University degree 3.8 12.0 15.8 0.8 -2.9 4.0 3.9 3.9 4.0 4.0 3.0
Eye problems/disorders: None of the above 0.2 0.3 0.6 -0.3 -0.8 0.5 0.4 0.4 0.5 0.5 0.7
Mouth/teeth dental problems: Loose teeth 3.3 3.9 5.1 -1.7 2.3 -2.0 -2.3 -2.2 -2.0 -2.0 -1.0
Emphysema/chronic bronchitis 1.0 1.1 2.5 -1.5 -0.0 -0.7 -1.0 -1.6 -0.7 -0.7 -1.4
Medication for pain relief, constipation, heartburn 0.7 1.2 2.0 0.3 0.2 1.4 1.4 1.3 1.4 1.4 0.5
Neck or shoulder pain in last month 1.7 2.5 7.0 1.3 -0.6 1.5 1.7 2.6 1.5 1.5 1.3
Medication: Blood pressure 1.5 2.7 4.3 -0.9 0.8 -1.9 -1.8 -2.1 -1.9 -1.9 -1.3
Angina (self-reported) 0.3 0.4 0.7 0.4 -0.3 0.8 0.8 0.8 0.8 0.8 -0.4
Migraine (self-reported) 0.7 0.9 1.5 -0.5 -1.2 1.1 1.1 0.8 1.1 1.1 0.4
Medication: Ibuprofen 0.2 0.3 0.5 0.0 -0.1 -0.7 -0.7 -0.5 -0.7 -0.7 -0.1
Medication: Allopurinol 1.2 1.6 3.7 -0.7 0.8 -1.3 -1.6 -1.9 -1.3 -1.3 0.4
Medication: Omeprazole 0.8 0.9 3.4 -1.3 -0.8 -0.6 -0.5 -0.6 -0.6 -0.6 -1.8
Medication: Seretide 50 evohaler 2.2 2.5 3.8 0.8 1.9 -1.7 -1.8 -1.8 -1.7 -1.7 0.4
Mean time to correctly identify matches 0.4 0.8 1.5 0.2 1.2 -0.9 -0.9 -0.9 -0.9 -0.9 -0.6
Heart disease (mother) 0.6 0.7 1.3 -0.9 -0.9 0.8 0.8 0.5 0.8 0.8 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.1 0.6 -0.8 0.9 0.7 0.8 0.9 0.9 1.8
Whole body fat mass 6.8 28.5 42.9 -0.0 6.1 -5.9 -6.0 -6.5 -5.9 -5.9 -2.6
Leg fat mass (right) 5.6 21.6 34.1 0.3 5.4 -5.1 -5.2 -5.8 -5.1 -5.1 -2.4
Arm predicted mass (right) 1.2 6.3 10.4 1.2 2.2 -2.8 -2.9 -3.2 -2.8 -2.8 -1.2
Pulse rate, automated reading 3.0 9.6 15.8 0.3 3.4 -3.5 -3.6 -4.0 -3.5 -3.5 0.0
Alcohol intake frequency. 0.3 0.7 3.5 -1.3 0.8 0.1 0.1 -0.3 0.1 0.1 -1.9
Comparative height size at age 10 0.0 0.1 1.0 0.2 0.0 -0.2 -0.3 0.0 -0.2 -0.2 1.0
Number of full sisters 0.2 0.2 0.6 0.6 -0.5 0.2 0.1 0.8 0.2 0.2 0.4
Suffer from ‘nerves’ 0.3 0.5 2.3 -1.5 0.1 0.1 -0.1 -0.7 0.1 0.1 -0.8
Overall health rating 0.7 1.5 2.4 -0.4 1.5 -1.5 -1.4 -1.1 -1.5 -1.5 -0.3
Chest pain or discomfort 0.4 0.5 2.7 0.7 1.6 -0.4 -0.3 0.2 -0.4 -0.4 -0.8
Had major operations 2.3 2.7 6.2 2.5 1.2 -1.9 -1.5 -0.7 -1.9 -1.9 0.7
Age at last live birth 0.7 1.0 1.7 -0.1 0.3 1.3 1.3 0.7 1.3 1.3 -0.7
Family relationship satisfaction 4.6 5.7 8.1 -2.8 2.5 -2.5 -2.5 -2.0 -2.5 -2.5 -1.4
Leg pain on walking 0.6 0.7 1.9 -0.5 0.5 -0.6 -0.8 -1.3 -0.6 -0.6 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 2.1 -0.9 0.7 -1.4 -1.4 -1.3 -1.4 -1.4 -1.2
Commuting to job workplace: Car/motor vehicle 1.0 1.1 6.4 0.1 -2.5 0.8 0.7 0.6 0.8 0.8 -0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 3.6 0.4 -1.9 0.4 0.3 -0.3 0.4 0.4 -1.1
Medication: Aspirin 0.6 0.8 4.5 -0.6 -0.8 0.3 0.1 -0.7 0.3 0.3 -2.1
Supplements: Vitamin C 0.5 0.6 2.2 0.4 -1.1 0.3 0.3 0.8 0.3 0.3 1.5
Knee pain experienced in last month 0.6 0.9 2.6 1.3 1.6 -0.5 -0.5 -0.1 -0.5 -0.5 1.4
Hypertension (Self-reported) 0.4 1.2 3.6 1.9 1.8 -0.8 -0.7 -0.9 -0.8 -0.8 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.2 -0.1 0.4 -0.9 -1.0 -1.2 -0.9 -0.9 -1.8
Illnesses of father: Heart disease 0.1 0.1 0.4 0.6 -0.5 -0.4 -0.2 -0.2 -0.4 -0.4 0.0
Illnesses of siblings: Diabetes 8.6 10.6 15.4 -1.9 3.8 -3.2 -3.5 -3.9 -3.2 -3.2 -2.9
Smoking status: Previous 2.7 4.0 6.6 0.8 2.1 -2.0 -2.0 -2.6 -2.0 -2.0 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.9 -0.4 -1.0 -0.3 -0.4 -0.2 -0.3 -0.3 0.6
Whole body fat-free mass 1.5 8.6 11.6 1.1 2.9 -3.4 -3.3 -3.4 -3.4 -3.4 -1.6
Leg fat-free mass (right) 2.9 15.2 19.6 0.5 4.3 -4.4 -4.4 -4.4 -4.4 -4.4 -2.4
Arm fat percentage (left) 7.5 30.0 47.8 -0.7 6.9 -5.8 -5.9 -6.5 -5.8 -5.8 -3.5
Average weekly red wine intake 0.3 0.5 0.8 -0.2 0.3 -0.7 -0.9 -0.8 -0.7 -0.7 0.8
Handedness (chirality/laterality): Left-handed 1.3 1.6 2.9 -1.4 -1.7 1.2 1.1 0.6 1.2 1.2 -1.5
Mood swings 3.3 5.9 7.3 -2.3 2.5 -2.7 -2.7 -2.2 -2.7 -2.7 -1.3
Loneliness, isolation 0.6 0.8 3.3 1.0 1.8 -0.6 -0.4 -0.6 -0.6 -0.6 -0.7
Long-standing illness, disability or infirmity 0.4 0.6 1.3 1.2 0.8 -0.9 -0.7 -0.6 -0.9 -0.9 0.2
Ever had bowel cancer screening 0.5 0.6 1.9 1.1 -0.9 0.3 0.3 0.5 0.3 0.3 1.4
Diabetes diagnosed by doctor 3.3 5.4 8.4 -0.3 2.7 -2.6 -2.6 -2.9 -2.6 -2.6 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.9 -2.0 1.1 -0.6 -0.6 -0.2 -0.6 -0.6 -1.0
Friendships satisfaction 0.9 1.1 6.5 0.7 0.4 0.0 0.2 1.2 0.0 0.0 2.5
Qualifications: nursing, teaching 0.9 1.3 2.2 0.9 -0.6 1.3 1.5 1.4 1.3 1.3 0.4
Commuting to job workplace: Walk 0.8 0.8 2.9 -1.7 0.3 -0.9 -0.7 -0.5 -0.9 -0.9 -0.0
Eye problems/disorders: Cataract 0.5 0.6 1.7 -0.9 -0.1 -0.8 -0.6 -0.1 -0.8 -0.8 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 0.8 -0.4 -0.4 -0.3 0.2 -0.4 -0.4 1.0
Medication for cholesterol 0.4 0.6 1.8 -0.5 -1.1 0.5 0.7 1.4 0.5 0.5 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.2 0.3 -1.1 0.7 0.4 0.1 0.7 0.7 0.5
Back pain experienced in last month 3.9 5.7 8.0 2.5 -1.5 2.7 2.6 2.8 2.6 2.6 1.2
Mineral and other dietary supplements 0.4 0.5 1.8 -1.4 0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6
Breast cancer (self-reported) 0.1 0.1 0.3 0.5 0.5 0.3 0.3 0.2 0.3 0.3 -0.0
Asthma (self-reported) 3.3 6.5 8.9 -1.1 1.4 -3.0 -2.9 -3.0 -3.0 -3.0 -2.2
Osteoporosis (self-reported) 0.9 1.1 1.7 -0.5 -1.0 1.3 1.3 0.7 1.3 1.3 -0.8
Osteoarthritis (self-reported) 0.3 0.4 1.8 1.3 -0.5 0.4 0.3 0.2 0.4 0.4 0.5
Medication: Aspirin 0.4 0.5 3.0 -0.1 -0.7 0.2 0.1 -0.6 0.2 0.2 -1.7
Medication: Gliclazide 0.5 0.5 1.2 1.1 0.6 -0.8 -0.7 -0.6 -0.8 -0.8 0.4
Illnesses of father: None of the above (group 1) 0.4 0.5 0.9 -0.5 0.8 0.7 0.7 1.0 0.7 0.7 0.4
Smoking status: Current 1.5 2.3 3.7 0.3 1.5 -1.9 -1.8 -1.3 -1.9 -1.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 5.1 0.6 -0.7 0.6 0.6 0.6 0.6 0.6 2.3
Whole body water mass 1.5 8.8 11.6 1.1 3.0 -3.4 -3.4 -3.4 -3.4 -3.4 -1.6
Leg predicted mass (right) 2.7 14.5 18.6 0.5 4.2 -4.3 -4.3 -4.3 -4.3 -4.3 -2.3
Arm fat mass (left) 6.5 26.7 39.3 -0.1 6.3 -5.6 -5.7 -6.3 -5.6 -5.6 -3.2
Number of self-reported non-cancer illnesses 2.6 4.4 7.2 -0.5 2.0 -2.2 -2.2 -2.7 -2.2 -2.2 -2.3
Average weekly champagne plus white wine intake 0.2 0.3 1.8 -1.3 0.2 0.1 -0.3 -0.9 0.1 0.1 -0.0
Miserableness 0.2 0.4 2.3 0.3 -0.5 -0.1 0.3 1.5 -0.1 -0.1 0.7
Guilty feelings 0.1 0.2 0.6 0.2 0.8 -0.1 -0.3 -0.7 -0.1 -0.1 -0.2
Wears glasses or contact lenses 1.0 1.2 1.6 1.2 -0.5 1.3 1.2 1.0 1.3 1.3 0.7
Ever taken oral contraceptive pill 0.5 0.5 2.2 0.4 -0.9 0.5 0.3 -0.4 0.5 0.5 -1.5
Hearing aid user 1.7 1.9 9.8 3.1 0.4 0.2 0.5 1.0 0.2 0.2 2.0
Mother’s age at death 4.9 6.2 8.3 1.8 -2.7 2.8 2.9 2.5 2.8 2.8 1.0
Financial situation satisfaction 6.2 7.7 11.3 -2.8 3.4 -2.8 -2.6 -2.1 -2.8 -2.8 -2.7
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.0 0.2 2.0 -1.1 -1.2 -0.8 -1.1 -1.1 0.5
Commuting to job workplace: Public transport 0.3 0.4 0.8 0.8 0.9 0.6 0.6 0.4 0.6 0.6 -0.3
Eye problems/disorders: Glaucoma 0.2 0.3 0.9 -0.9 0.5 -0.2 -0.3 -0.3 -0.2 -0.2 -0.9
Medication: Blood pressure 0.4 0.8 5.2 0.6 2.3 -0.0 -0.1 -0.6 -0.0 -0.0 -0.8
Pain type(s) experienced in last month: Hip pain 0.6 0.8 3.8 0.6 1.9 -0.6 -0.8 -0.7 -0.6 -0.6 0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.8 1.7 -0.2 0.2 0.2 0.0 0.2 0.2 0.8
High cholesterol (Self-reported) 0.8 1.3 6.0 -1.2 -0.2 -0.6 -0.7 -1.3 -0.6 -0.6 -2.4
Medication: Bendroflumethiazide 0.2 0.3 1.7 1.3 0.4 0.4 0.4 -0.0 0.4 0.4 -0.3
Medication: Paracetamol 0.4 0.6 2.4 1.0 -0.5 -0.3 -0.5 -0.4 -0.3 -0.3 1.5
Medication: Lisinopril 0.5 0.6 1.5 -0.5 -0.0 -0.8 -0.9 -1.2 -0.8 -0.8 -0.7
Medication: Atorvastatin 0.9 1.1 2.3 -0.6 1.1 -1.0 -1.3 -1.5 -1.0 -1.0 -0.6
Illnesses of father: High blood pressure 1.6 2.0 2.9 -0.9 0.7 -1.6 -1.6 -1.7 -1.6 -1.6 -1.2
Alcohol drinker status: Never 0.3 0.3 1.5 -0.6 1.2 0.1 -0.1 -0.5 0.1 0.1 0.5
Ever smoked 2.2 3.8 5.1 2.0 2.3 -2.0 -1.9 -2.0 -2.0 -2.0 -1.0
Basal metabolic rate 2.3 12.7 17.5 0.8 3.7 -4.0 -4.0 -4.2 -4.0 -4.0 -2.0
Leg fat percentage (left) 4.5 16.5 27.5 -0.2 4.6 -4.3 -4.5 -5.2 -4.3 -4.3 -2.5
Arm fat-free mass (left) 1.3 6.8 10.6 1.3 2.6 -2.9 -3.0 -3.3 -2.9 -2.9 -1.2
Number of operations (self-reported) 1.3 1.9 4.0 1.0 2.0 -1.6 -1.3 -0.8 -1.6 -1.6 -0.1
Average weekly beer plus cider intake 3.6 5.3 7.7 -0.8 2.1 -2.8 -2.8 -2.5 -2.8 -2.8 -0.1
Irritability 1.6 2.7 3.2 -1.8 1.4 -1.7 -1.6 -1.5 -1.7 -1.7 -1.5
Risk taking 0.8 1.1 3.4 1.2 1.8 -1.1 -0.8 -0.4 -1.0 -1.0 0.4
Ever had prostate specific antigen (PSA) test 1.1 1.3 2.3 -0.7 0.1 -1.4 -1.5 -1.1 -1.4 -1.4 0.3
Fractured/broken bones in last 5 years 0.3 0.3 1.6 0.9 0.5 -0.1 0.1 -0.1 -0.1 -0.1 -1.3
Age started oral contraceptive pill 1.0 1.3 1.9 0.7 0.7 1.4 1.2 1.1 1.4 1.4 0.9
Diastolic blood pressure, automated reading 0.3 1.0 3.5 1.9 0.6 -0.7 -0.7 -1.2 -0.7 -0.7 1.0
Ever depressed for a whole week 0.3 0.3 0.9 0.4 1.0 0.6 0.6 0.2 0.6 0.6 -0.5
Unable to work because of sickness or disability 0.2 0.2 1.2 0.0 1.1 0.3 0.3 0.2 0.3 0.3 -0.5
Commuting to job workplace: Cycle 0.4 0.5 2.7 -1.2 0.1 -0.0 0.1 0.3 -0.0 -0.0 -1.6
Myopia 0.2 0.3 0.9 0.8 1.0 -0.5 -0.3 0.4 -0.5 -0.5 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 2.2 -1.5 -0.7 -0.0 -0.1 0.3 -0.0 -0.0 -0.1
Cholesterol lowering medication 0.3 0.4 1.7 0.0 0.6 0.1 -0.1 -0.9 0.1 0.1 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 5.9 -2.4 0.1 -1.2 -1.1 -0.8 -1.2 -1.2 -2.1
Pain experienced in last month 0.1 0.1 0.3 0.6 -0.0 0.3 0.3 -0.4 0.3 0.3 -0.2
Supplements: Calcium 4.0 4.4 6.2 1.3 -2.4 2.1 2.2 2.5 2.1 2.1 1.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.5 -0.8 -1.0 -0.1 -0.0 -0.1 -0.1 -0.1 -1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 0.9 -0.5 0.7 0.5 -0.1 0.7 0.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 4.5 -2.1 0.2 0.9 0.4 -0.3 0.9 0.9 -1.5
Heart disease (siblings) 0.4 0.5 3.1 -0.6 -0.8 -0.1 0.0 0.1 -0.1 -0.1 -1.7
Alcohol drinker status: Previous 0.0 0.1 0.3 -0.2 -0.1 0.1 0.2 -0.1 0.1 0.1 -0.5
Pack years of smoking 0.9 1.3 5.6 2.4 1.3 -0.9 -0.6 -0.2 -0.9 -0.9 0.5
Impedance of whole body 0.6 3.0 5.6 -1.6 -1.9 1.6 1.3 1.6 1.6 1.6 2.4
Leg fat mass (left) 5.6 21.7 34.7 0.0 5.3 -5.1 -5.2 -5.9 -5.1 -5.1 -2.6
Arm predicted mass (left) 1.4 7.0 11.6 1.0 2.5 -2.9 -3.0 -3.4 -2.9 -2.9 -1.4