Hub : Genes

PROS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1060 0.0340 3.0e-10 0.086 0.104 0.101 0.108 0.104 1.4e-10 1.3e-12 3.1e-12 4.7e-13 1.2e-12
2 GTEx Adipose Subcutaneous 0.0860 0.0400 1.0e-03 0.057 NA 0.056 NA 0.052 2.0e-05 NA 2.4e-05 NA 4.5e-05
3 GTEx Heart Atrial Appendage 0.3100 0.1030 5.1e-06 0.160 NA 0.187 NA -0.005 1.2e-07 NA 8.5e-09 NA 6.7e-01
4 GTEx Heart Left Ventricle 0.1476 0.0677 8.1e-05 0.076 NA 0.000 NA 0.010 7.0e-05 NA 3.0e-01 NA 9.0e-02
5 GTEx Lung 0.0744 0.0429 4.9e-03 -0.003 NA 0.002 NA -0.004 6.5e-01 NA 2.3e-01 NA 8.8e-01
6 GTEx Skin Sun Exposed Lower leg 0.0480 0.0220 2.1e-03 0.023 NA 0.022 NA 0.020 5.0e-03 NA 5.3e-03 NA 8.0e-03
7 TCGA Breast Invasive Carcinoma 0.0138 0.0082 4.8e-03 0.005 0.009 0.002 NA 0.004 3.3e-02 4.2e-03 1.0e-01 NA 5.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.0 1.6 3.8 -1.1 -1.3 -1.8 1.9 0.0 -1.0 -0.5
Bipolar Disorder or Schizophrenia 0.2 0.5 1.2 0.4 -0.6 -0.0 0.7 0.9 -0.5 1.1
Depressed Affect (Nagel 2018) 0.2 0.5 1.4 -0.5 -0.5 -1.2 1.0 -0.3 0.3 -0.7
Depression (Nagel 2018) 0.3 0.4 1.2 0.2 0.4 0.5 -0.4 -0.8 1.1 -0.6
Intelligence (Savage-Jansen 2018) 1.0 3.0 8.2 -0.4 -0.5 2.9 -2.9 1.3 -1.5 -0.7
Neuroticism (Nagel 2018) 0.2 0.5 1.3 -0.4 -0.6 -0.8 0.8 -1.1 0.1 -0.8
Schizophrenia (2018) 0.6 1.3 3.2 1.4 0.2 1.4 -0.6 1.0 0.0 1.8
Schizophrenia vs Biploar Disorder 3.2 4.3 8.4 2.2 2.4 2.9 -2.8 0.0 1.0 1.5
Worry (Nagel 2018) 0.1 0.3 1.3 0.3 -0.1 0.3 -0.3 -1.2 -0.2 -0.6
Alzheimer’s Disease (in mother) 0.4 0.4 2.3 -0.5 -0.6 0.1 -1.5 0.2 0.0 0.2
Alzheimer’s Disease (in father) 0.9 0.9 2.2 1.0 0.2 1.4 -1.5 0.8 0.3 0.7
Alzheimer’s Disease (including proxy) 1.0 1.5 6.2 0.9 0.3 1.3 -2.5 0.6 0.6 1.0
Crohns Disease (2017) 0.4 0.9 1.5 -1.2 -1.2 -0.9 0.9 0.1 -0.6 -1.1
Irritable Bowel Disease (IBD) 0.6 1.5 3.4 -1.5 -0.4 -1.8 1.7 -0.7 -0.3 -1.1
Ulcerative Colitis (UC) 0.7 1.3 2.8 -1.3 0.2 -1.7 1.5 -1.1 -0.4 -1.1
Major Depression (MDD) 1.6 2.0 5.3 -2.2 -1.1 -1.1 0.7 -0.7 -0.4 -2.3
Reaction Time 0.3 0.6 1.4 -0.5 0.1 -1.2 1.2 -0.6 -0.4 -0.5
Verbal and Numeric Reasoning (VNR) 0.8 2.0 7.0 0.4 0.1 2.6 -2.0 1.7 -0.2 -0.1
Breast Cancer 0.1 0.4 1.1 0.2 0.9 -0.3 -1.0 -0.5 0.5 0.1
Ovarian Cancer 0.9 1.2 4.0 1.0 0.4 1.5 -2.0 -0.0 -0.6 0.9
Prostate Cancer 0.7 0.9 2.2 1.5 1.0 1.2 0.8 1.1 -0.1 0.3
Age at First Birth 1.7 2.5 4.8 1.8 1.2 2.1 -2.2 0.8 1.3 1.1
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.7 -0.7 -0.7 0.2 0.0 0.5 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 2.8 -1.1 -1.7 -1.6 1.1 0.6 -1.5 -0.2
Coronary Artery Disease (CAD) 2.4 2.9 5.6 1.5 2.0 1.5 -0.0 2.0 2.4 1.4
Crohns Disease (2012) 0.3 0.4 2.2 0.1 0.3 0.8 0.1 0.0 1.5 0.4
Mean Putamen Volume 0.6 0.7 1.6 -1.3 -1.2 -0.3 -0.3 0.8 -0.5 -0.6
Fasting Glucose 0.5 0.6 1.3 0.0 -0.9 -1.0 0.6 -0.5 -1.1 0.5
HbA1C 0.6 0.7 1.7 -0.4 -0.5 -1.2 1.3 1.1 -0.1 0.2
HDL Cholesterol 0.6 0.9 3.2 -0.3 0.2 -1.4 1.8 -0.8 -0.3 -0.7
LDL Cholesterol 0.2 0.3 0.9 -0.6 0.3 -0.4 -0.2 -0.8 0.0 -0.9
Lupus 0.4 0.5 1.4 1.2 1.0 0.6 -0.4 -0.3 0.6 0.5
Neuroticism (2016) 0.1 0.2 0.7 -0.2 -0.1 -0.3 -0.7 -0.8 0.4 -0.3
Primary Biliary Cirrhosis 0.7 1.0 2.1 -1.2 -0.8 -1.4 1.0 -0.1 -0.7 -1.3
Rheumatoid Arthritis 2.2 3.1 6.7 -2.4 -2.6 -0.9 0.7 -0.2 -2.1 -1.8
Schizophrenia (2014) 0.8 1.8 3.5 1.8 0.6 1.9 -1.5 0.8 0.2 1.7
Triglycerides 0.1 0.1 0.3 -0.4 0.1 0.0 -0.2 -0.5 0.3 -0.1
Type 2 Diabetes (T2D) (2012) 1.2 1.4 4.4 -1.0 -1.6 -2.1 0.6 0.4 -1.0 0.0
Ulcerative Colitis 0.8 1.1 3.8 -0.7 0.3 -1.3 1.9 0.0 1.3 -0.6
Blood Eosinophil Count 0.3 2.7 6.5 -2.5 -1.7 -1.9 1.3 0.3 -2.0 -0.4
Blood Platelet Count 0.0 0.5 1.1 -1.1 -0.8 0.4 -0.9 1.0 -0.1 -0.0
Blood Red Count 0.3 2.5 8.3 -1.3 -0.9 0.3 -1.6 -2.9 -1.4 -1.6
Blood White Count 0.3 2.4 7.8 -2.8 -1.8 -0.9 -0.3 1.2 -1.8 -0.8
Heel T-Score 0.3 2.1 7.8 0.6 -1.1 -0.9 0.9 2.8 -0.2 1.8
BMI 3.9 22.6 59.9 -4.9 -5.0 -7.7 5.6 -0.7 -3.9 -1.5
Height 0.3 5.8 11.4 2.3 2.2 1.8 0.1 3.4 3.1 2.6
Waist Hip Ratio (WHR) 0.1 0.6 2.6 0.4 0.7 0.8 -0.5 -0.4 1.6 0.1
Systolic Blood Pressure 0.1 0.6 1.8 0.8 -0.7 0.7 0.2 1.4 0.2 0.9
Smoking Status 0.9 2.2 8.6 -1.5 -0.9 -2.9 1.8 0.1 -0.4 0.0
Allergy or Eczema 0.1 0.2 0.8 -0.2 -0.5 -0.9 0.5 -0.4 -0.4 -0.0
Cardiovascular Disease 0.9 3.0 7.9 -1.5 -2.0 -2.3 2.8 0.4 -0.9 -0.8
Hypothyroidism (self reported) 0.6 1.3 4.0 -0.8 -1.0 -0.6 0.4 -2.0 -1.1 -1.4
Respiratory disease 2.3 5.1 10.5 -1.9 -2.7 -3.2 2.9 0.1 -1.8 -1.5
Type 2 Diabetes (T2D) (2018) 1.0 1.9 6.4 -1.4 -0.6 -2.5 1.6 -1.2 -0.7 -0.0
Lung FEV1/FVC ratio 1.4 7.0 18.4 -2.8 -2.6 -4.3 2.4 -0.9 -2.5 -1.7
Lung FVC 0.8 4.2 7.2 2.1 2.6 1.8 -2.1 0.6 2.7 1.7
Neuroticism 0.2 0.6 1.2 -0.1 0.2 -1.0 1.1 -0.9 0.7 -0.6
Chronotype (morning person) 0.0 0.1 0.4 0.0 0.2 -0.6 0.2 0.1 0.4 -0.0
Hair Pigment 0.0 0.4 1.3 0.5 0.2 -0.7 0.5 1.2 0.5 0.8
Tanning 0.2 1.9 5.8 0.9 0.7 0.8 -0.3 2.4 1.1 2.1
Hand grip strength (left) 0.5 1.2 2.0 1.1 1.1 1.4 -0.6 1.1 1.4 0.9
Number of treatments/medications taken 2.9 5.2 9.7 -2.2 -2.5 -3.1 2.5 -1.5 -1.9 -1.9
Average weekly spirits intake 2.4 3.0 8.0 -2.2 -1.5 -2.8 2.2 0.6 -0.6 -0.3
Sensitivity / hurt feelings 0.2 0.3 0.9 0.2 -0.0 -0.4 0.9 0.6 0.9 -0.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.6 0.0 0.9 0.7 -0.6 -0.2 1.3 -0.4
Hearing difficulty/problems: Yes 0.4 0.7 1.5 -0.8 -1.2 -0.0 -1.1 0.7 -0.8 0.4
Relative age of first facial hair 0.0 0.1 0.2 -0.0 0.4 0.1 -0.4 -0.2 0.3 0.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.0 -0.8 -0.1 0.2 -0.8 -1.7 0.7 -1.0
Ever used hormone-replacement therapy (HRT) 1.7 2.1 4.9 -0.4 -1.7 -1.2 1.3 -2.2 -1.7 -1.0
Ever had hysterectomy (womb removed) 0.7 0.8 1.7 -1.3 -1.2 -1.2 0.1 -0.6 -0.8 -0.6
Systolic blood pressure, automated reading 0.3 0.8 2.4 0.8 -0.6 -0.1 0.8 1.6 0.5 1.2
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 3.0 -1.4 -1.4 -1.5 1.7 0.6 -1.6 -0.4
Angina 0.3 0.4 0.9 -0.5 -0.4 0.3 -0.7 -0.5 -0.9 -1.0
Medication for hormone replacement therapy 0.7 0.8 1.3 -0.5 -1.0 -1.0 1.1 -1.1 -0.8 -0.6
Vitamin and mineral supplements 0.9 1.2 2.4 -1.5 -0.8 -0.8 1.2 -0.6 -1.0 -1.3
Supplements: Zinc 0.3 0.3 0.9 -0.3 -0.1 -0.0 -0.8 -1.0 -0.8 -0.1
Medication: Co-codamol 0.4 0.4 1.0 0.4 0.6 0.3 0.6 0.6 1.0 0.8
Medication: Metformin 1.9 2.7 9.5 -1.7 -1.4 -3.1 1.9 0.0 -1.0 0.2
Diabetes (father) 0.4 0.5 1.1 -0.5 -0.8 -1.1 0.8 -0.5 -0.8 0.0
Diabetes (mother) 1.1 1.4 3.3 -1.5 -1.4 -1.8 0.6 -0.7 -1.1 -0.3
Severe depression (siblings) 0.2 0.2 0.5 0.4 -0.2 0.3 -0.4 0.7 -0.5 0.5
Pack years adult smoking proportion 0.9 1.4 2.2 -1.5 -1.5 -1.5 1.1 0.6 -1.1 0.3
Impedance of leg (right) 2.2 10.6 19.4 4.3 3.6 4.4 -3.1 0.2 2.7 2.4
Leg fat-free mass (left) 1.4 7.3 18.7 -3.1 -2.3 -4.3 3.5 1.5 -1.7 -0.4
Trunk fat percentage 2.1 8.3 26.3 -2.8 -2.3 -5.1 4.0 0.5 -1.6 0.2
Hand grip strength (right) 0.7 1.8 4.5 1.3 1.8 1.6 -0.5 0.7 2.1 0.3
Townsend deprivation index at recruitment 1.6 2.3 6.9 -1.4 -0.5 -2.6 2.1 0.0 -1.3 -0.8
Current tobacco smoking 0.2 0.4 1.1 -0.4 0.0 -1.0 0.9 0.5 0.1 0.5
Average weekly fortified wine intake 0.2 0.2 0.9 0.3 0.3 0.2 0.0 0.9 0.7 -0.1
Maternal smoking around birth 1.3 1.9 7.3 -0.5 -0.9 -2.2 2.7 -0.4 0.3 0.2
Fed-up feelings 0.5 0.9 2.5 0.5 0.9 -0.8 1.5 -0.3 1.6 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.9 0.1 0.8 0.6 -0.8 -0.8 0.5 -1.0
Relative age voice broke 0.3 0.4 1.0 0.8 0.6 -0.1 0.1 0.3 1.0 0.8
Taking other prescription medications 0.6 1.0 2.1 -1.1 -1.5 -1.2 0.8 -1.0 -0.3 -0.5
Age when periods started (menarche) 0.1 0.1 0.4 0.1 0.4 0.1 -0.6 0.1 -0.1 0.5
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.7 -1.8 -1.6 -1.9 0.5 0.3 -1.2 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.8 0.4 -0.2 -1.1 1.7 1.1 -0.2 1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.0 -0.5 -0.6 -1.0 0.6 0.1 -0.2 0.7
Qualifications: CSEs or equivalent 0.4 0.5 1.7 0.6 0.3 0.4 -0.5 1.3 0.1 0.8
Serious illness, injury or assault to yourself 0.7 0.8 1.8 0.6 1.0 0.0 0.3 0.9 1.2 1.3
High blood pressure 0.4 1.2 2.3 -1.0 -1.4 -0.9 1.5 1.4 -0.3 -0.2
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.1 -1.1 -1.2 -1.8 1.2 -0.9 -0.7 -0.7
Multivitamins +/- minerals 0.6 0.8 1.7 1.2 0.3 0.6 -1.3 0.8 0.4 1.1
Stomach or abdominal pain in last month 0.2 0.2 0.6 0.3 0.7 0.5 -0.2 -0.2 0.8 -0.0
Supplements: Glucosamine 0.6 0.7 1.8 1.1 0.2 1.0 -1.4 -0.4 0.3 0.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.2 1.1 1.8 0.8 -0.2 -0.2 1.7 0.8
Medication: Atenolol 1.2 1.5 3.0 -1.7 -1.6 -1.2 0.9 -0.5 -0.9 -1.1
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.3 -0.1 0.2 -0.7 -0.7 0.2 -0.4
Sitting height 0.1 0.8 2.2 -0.5 0.3 -1.1 1.5 0.8 1.1 0.3
Chronic bronchitis/emphysema (father) 0.1 0.1 0.5 0.4 -0.0 0.1 0.1 -0.0 0.1 0.7
High blood pressure (mother) 0.6 0.8 3.0 0.2 -0.6 -0.5 1.7 -0.3 -1.2 -0.6
Body mass index (BMI) 3.5 15.0 37.3 -4.1 -4.0 -6.1 4.7 0.2 -3.4 -1.2
Impedance of leg (left) 1.9 9.3 17.5 4.2 3.5 4.1 -2.5 0.3 2.7 2.2
Leg predicted mass (left) 1.3 7.0 18.2 -3.0 -2.2 -4.3 3.5 1.6 -1.6 -0.3
Trunk fat mass 2.4 10.3 29.8 -3.2 -2.8 -5.5 4.4 0.9 -1.9 -0.1
Waist circumference 2.9 10.6 26.4 -3.7 -3.4 -5.1 3.8 0.1 -2.5 -1.2
Number of incorrect matches in round 0.7 1.2 2.9 -1.7 -1.5 -0.9 0.5 0.2 -1.1 -0.9
Past tobacco smoking 2.1 3.8 10.5 1.9 2.4 3.2 -2.0 -0.6 1.6 0.3
Alcohol usually taken with meals 1.4 2.3 3.6 1.7 1.7 1.5 -1.9 -0.5 1.9 1.0
Nervous feelings 0.2 0.4 1.4 0.2 -0.5 0.6 -0.1 -1.2 -0.4 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.3 -0.9 -0.4 0.2 -0.3 -0.1 -0.1 -1.5
Hearing difficulty/problems with background noise 1.4 2.3 5.5 -2.3 -2.0 -1.3 -0.4 -0.7 -1.6 -1.3
Hair/balding pattern: Pattern 2 0.3 0.4 0.9 0.6 0.3 0.8 -0.9 0.5 0.4 0.5
Had menopause 0.2 0.3 1.2 0.4 -0.3 1.1 -0.6 -0.2 0.1 0.5
Had other major operations 0.2 0.3 1.5 -0.3 -0.0 -0.3 0.5 0.1 1.2 0.4
Forced vital capacity (FVC) 1.9 7.3 12.5 2.6 3.4 2.9 -2.0 2.0 3.5 2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 4.0 1.1 0.2 -0.3 1.2 2.0 0.8 1.7
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.8 -1.4 -1.3 -0.3 0.2 -1.3 -0.9 -1.3
Qualifications: None of the above 0.4 0.9 2.7 -0.4 -1.0 -1.6 0.5 -0.3 -1.0 1.1
Financial difficulties in last 2 years 0.2 0.3 0.7 -0.7 -0.7 -0.6 0.9 -0.0 -0.1 -0.2
Mouth/teeth dental problems 0.1 0.1 0.4 -0.4 -0.2 0.1 0.0 0.0 -0.2 -0.6
Heart attack 0.5 0.7 2.6 -0.3 -1.2 -0.6 -0.2 0.0 -1.6 -0.1
Allergy 1.7 4.0 10.4 1.9 1.8 3.2 -2.6 0.7 1.1 1.6
Pain all over the body in last month 0.5 0.5 1.5 -0.1 -0.7 -1.0 1.2 -0.5 -0.3 -0.4
Diabetes (self-reported) 1.1 1.8 5.0 -1.5 -1.1 -2.2 1.4 -0.2 -1.3 0.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 4.1 -1.1 -1.0 -2.0 1.6 -0.2 -0.2 -0.3
Medication: Ramipril 0.4 0.5 2.8 0.2 0.5 0.3 0.1 1.7 0.1 0.4
Medication: Simvastatin 9.1 13.3 17.2 -3.7 -4.1 -4.1 3.2 -3.7 -3.3 -3.2
Fluid intelligence score 0.6 1.2 2.1 -0.8 -0.8 1.4 -1.2 1.1 -1.5 -1.0
Illnesses of siblings 0.5 0.8 1.8 0.6 0.5 1.2 -1.4 1.0 0.3 0.7
Neuroticism score 0.2 0.4 1.1 -0.4 -0.4 -0.7 1.0 -0.6 0.3 -0.9
Weight 2.1 10.4 27.4 -3.3 -3.0 -5.2 4.4 1.4 -2.2 -0.4
Impedance of arm (right) 0.8 3.7 7.5 1.8 2.7 1.9 -1.9 -1.3 2.4 1.0
Arm fat percentage (right) 3.6 14.3 39.8 -4.2 -3.4 -6.3 4.7 -0.8 -2.7 -1.2
Trunk fat-free mass 0.7 3.8 7.5 -1.7 -1.8 -2.6 2.7 2.3 -1.1 0.0
Hip circumference 2.3 9.8 24.7 -3.6 -3.0 -5.0 3.6 -0.1 -2.8 -1.3
Time employed in main current job 0.3 0.4 0.9 -0.5 0.3 0.5 -1.0 -0.7 0.6 -0.5
Alcohol intake versus 10 years previously 2.3 3.5 5.6 -2.2 -2.0 -2.1 0.7 -1.5 -2.4 -1.8
Father’s age at death 0.8 1.1 2.4 1.6 1.2 1.2 -0.5 0.9 0.8 0.8
Worrier / anxious feelings 0.8 1.6 3.2 1.8 1.6 1.5 -1.1 0.1 1.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.7 0.2 0.7 1.3 -0.8 -0.1 0.9 -0.2
Falls in the last year 0.3 0.3 0.8 -0.4 -0.7 -0.9 0.8 0.4 -0.1 -0.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.6 -0.9 0.3 0.2 0.0 -1.3 -0.5 -1.2
Number of live births 0.7 0.9 2.4 -1.0 -1.6 -0.2 1.3 -0.0 0.0 -1.2
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 9.8 2.3 3.1 2.4 -1.8 1.8 2.8 1.7
Pulse rate 1.3 2.2 5.3 -0.0 -0.3 -1.6 1.9 2.3 0.9 1.7
Happiness 0.4 0.5 1.3 -0.5 -0.2 -0.9 1.1 -0.5 0.9 -0.4
Noisy workplace 0.2 0.3 0.6 -0.1 -0.2 -0.2 -0.7 0.8 0.1 0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.1 0.4 1.2 1.8 -0.6 1.2 1.1 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.5 0.5 -0.2 1.2 -0.1 1.6 1.1 0.1
Mouth/teeth dental problems: Dentures 0.7 1.1 3.7 -0.7 -1.0 -0.0 -0.4 -1.2 -1.9 -1.0
Asthma 3.9 7.7 16.5 -2.6 -3.0 -4.1 3.7 0.6 -1.9 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.0 0.6 -0.0 -0.8 1.7 1.7 0.0 0.8
Medication: Cholesterol lowering 4.2 6.6 9.0 -2.3 -2.4 -2.7 3.0 -2.4 -2.4 -2.7
Depression (self-reported) 0.4 0.5 1.6 0.2 0.5 -0.3 1.1 -0.7 1.2 -0.3
Medication: Lansoprazole 0.6 0.6 1.2 -0.9 -1.0 -0.3 0.2 1.0 -1.1 -0.6
Prospective memory result 0.7 0.8 3.2 -0.6 -0.8 -1.8 0.8 0.5 0.6 0.5
Lung cancer (father) 0.5 0.6 2.8 0.1 0.8 -0.4 0.4 -0.2 1.7 0.1
Illnesses of mother 0.3 0.4 1.4 -0.2 0.7 0.0 -0.5 0.7 1.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 7.8 1.7 2.8 1.6 -1.7 1.6 2.6 1.4
Pulse wave Arterial Stiffness index 0.1 0.2 0.9 -0.3 -0.1 -0.4 0.0 -0.9 -0.2 -0.0
Impedance of arm (left) 1.2 5.4 11.2 2.2 3.3 2.3 -2.5 -1.1 2.7 1.4
Arm fat mass (right) 3.3 13.8 37.9 -3.8 -3.4 -6.2 5.0 0.2 -2.7 -0.8
Trunk predicted mass 0.6 3.5 7.1 -1.6 -1.7 -2.5 2.7 2.2 -1.1 0.1
Standing height 0.4 3.8 8.5 1.7 1.8 1.5 -0.2 2.9 2.4 2.0
Length of working week for main job 1.0 1.1 2.5 0.6 1.5 0.7 -1.0 0.4 1.6 0.8
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.0 0.4 -0.2 -0.5 -0.8 0.2 0.6
Breastfed as a baby 1.9 2.4 4.7 0.9 1.9 2.2 -1.0 1.3 2.0 0.9
Tense / ‘highly strung’ 0.3 0.5 1.4 -0.7 -0.7 -0.0 0.9 -0.4 -0.5 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.5 -0.9 -1.1 -0.6 1.0 -1.2 -0.2 -1.1
Hair/balding pattern: Pattern 4 0.1 0.1 0.4 0.1 -0.3 -0.6 0.5 0.4 -0.0 -0.1
Birth weight of first child 0.1 0.2 0.5 -0.5 0.5 0.3 -0.6 -0.2 0.2 -0.7
Peak expiratory flow (PEF) 0.6 1.5 3.3 0.9 1.4 0.7 -0.1 1.8 1.8 0.8
Pulse wave reflection index 0.8 1.0 3.8 -0.6 -0.3 -0.6 -0.0 -1.9 -0.6 -1.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.9 0.4 1.0 -0.4 -0.3 -0.1 -0.0 0.5
Loud music exposure frequency 1.3 1.4 3.0 -1.4 -1.2 -1.7 1.0 0.3 -1.3 -0.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.3 0.2 -0.2 2.1 -1.2 0.5 -0.3 -1.3
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 6.8 1.3 0.9 0.3 -0.6 2.0 1.3 2.6
Blood clot in the leg (DVT) 0.9 1.2 5.9 0.0 0.6 -0.1 -0.5 -2.4 0.4 -1.3
Medication: Paracetamol 0.5 0.8 2.1 1.4 1.1 0.4 0.2 0.2 1.0 1.0
Headache pain in last month 0.5 0.8 2.1 0.8 0.7 1.4 -0.4 -1.4 0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 8.1 1.2 1.2 2.3 -2.8 0.8 1.0 1.4
Glaucoma (self-reported) 0.5 0.6 1.5 -1.2 -0.6 -0.8 0.6 -0.2 -0.1 -1.0
Gout (self-reported) 1.2 1.7 3.2 1.6 1.8 1.0 -0.6 0.7 1.5 1.4
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.2 -0.7 -1.0 -0.7 0.4 -1.5 -0.9 -1.1
Medication: Amlodipine 0.8 1.1 2.6 -1.6 -1.3 -0.6 0.9 -0.2 -0.2 -1.4
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.8 -1.2 -1.4 -1.7 1.0 1.3 -0.8 -0.5
Birth weight 0.7 1.5 3.6 0.1 1.7 0.8 -1.9 -0.2 1.8 0.1
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.4 0.6 0.4 -0.1 0.2 0.9 0.7 1.2
High blood pressure (siblings) 0.5 0.7 2.5 -0.3 -0.5 -0.9 1.6 -0.5 -0.4 -0.8
Forced vital capacity (FVC), Best measure 1.9 6.8 12.5 2.1 3.4 2.5 -2.3 2.0 3.5 2.0
Body fat percentage 2.4 9.3 28.7 -3.0 -2.6 -5.4 4.1 0.2 -2.0 -0.2
Leg fat percentage (right) 2.0 7.2 21.1 -2.4 -2.5 -4.6 3.6 0.1 -2.1 -0.3
Arm fat-free mass (right) 0.7 3.8 7.0 -1.6 -1.7 -2.6 2.6 2.4 -1.2 0.4
Exposure to tobacco smoke outside home 0.6 0.8 4.7 -0.5 -0.1 -0.4 0.3 2.2 0.8 0.0
Comparative body size at age 10 0.2 0.6 1.5 -0.7 -0.0 -0.8 0.8 -1.2 -0.5 -0.8
Number of full brothers 0.2 0.2 1.0 -0.2 0.1 1.0 -0.5 0.3 0.4 0.2
Worry too long after embarrassment 0.2 0.3 1.1 0.3 -0.1 1.0 -0.8 0.5 0.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 -0.3 0.1 0.1 0.3 0.2 0.1 0.3
Wheeze or whistling in the chest in last year 0.9 1.7 4.0 -0.9 -1.4 -2.0 1.8 -0.0 -1.0 -0.7
Number of children fathered 0.1 0.1 0.4 0.3 0.2 0.1 -0.1 -0.1 0.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.1 2.4 7.1 -0.3 -0.1 2.6 -2.7 -0.3 -0.9 -1.4
Age at first live birth 0.2 0.4 1.7 0.5 -0.1 1.3 -1.0 -0.0 -0.2 -0.3
Pulse wave peak to peak time 0.2 0.2 0.9 0.3 0.1 0.5 -0.1 0.9 0.3 0.1
Health satisfaction 0.8 1.0 2.1 -1.1 -0.1 -1.5 1.1 -0.7 0.8 -1.1
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.5 -0.6 -0.6 -0.0 0.6 -0.3 -0.1
Qualifications: College or University degree 2.7 8.6 22.1 2.5 2.8 4.7 -4.2 0.7 2.1 1.3
Eye problems/disorders: None of the above 0.3 0.4 0.7 0.8 0.4 0.6 -0.8 0.1 0.4 0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.5 0.1 1.2 -1.3 0.2 -1.9 0.9 0.1
Emphysema/chronic bronchitis 1.0 1.1 4.3 -0.2 -0.6 -1.2 2.1 -0.3 -0.6 -0.9
Medication for pain relief, constipation, heartburn 0.5 0.9 4.2 -0.5 -0.4 1.1 -2.0 -0.6 -0.4 -0.4
Neck or shoulder pain in last month 0.9 1.3 4.0 0.8 1.3 2.0 -0.8 0.4 1.1 0.5
Medication: Blood pressure 1.0 1.8 4.4 -1.2 -0.9 -2.1 2.0 -0.2 -0.8 -1.0
Angina (self-reported) 0.2 0.2 0.7 -0.6 -0.4 0.0 -0.4 -0.2 -0.5 -0.8
Migraine (self-reported) 0.2 0.3 1.2 0.4 -0.4 0.7 1.1 -0.2 0.1 -0.0
Medication: Ibuprofen 0.9 1.1 3.9 0.7 0.1 -0.5 1.5 2.0 0.1 0.7
Medication: Allopurinol 0.5 0.6 1.4 0.8 1.2 -0.3 0.5 0.3 1.1 0.8
Medication: Omeprazole 1.2 1.4 2.7 -0.9 -0.6 -1.3 1.6 -1.3 -0.3 -1.6
Medication: Seretide 50 evohaler 0.6 0.7 1.6 0.0 -0.6 -1.3 1.0 1.1 0.2 1.0
Mean time to correctly identify matches 0.2 0.4 1.4 -0.5 -0.3 -1.2 0.9 0.1 -0.6 -0.2
Heart disease (mother) 0.7 0.9 3.9 -0.3 -0.2 0.1 0.6 -2.0 0.2 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.0 1.6 1.5 1.7 -1.4 -0.7 1.1 1.5
Whole body fat mass 2.8 11.7 34.1 -3.4 -3.0 -5.8 4.7 0.6 -2.2 -0.2
Leg fat mass (right) 2.5 9.9 27.4 -3.2 -3.0 -5.2 4.0 0.4 -2.4 -0.4
Arm predicted mass (right) 0.9 4.5 8.6 -1.7 -1.9 -2.9 2.9 2.2 -1.6 0.3
Pulse rate, automated reading 0.8 2.7 6.8 -0.4 -0.4 -2.5 2.6 1.9 -0.1 1.4
Alcohol intake frequency. 1.7 4.1 5.8 -2.4 -2.0 -1.6 1.2 -2.0 -2.4 -2.2
Comparative height size at age 10 0.3 1.5 4.8 0.8 1.5 1.1 -0.4 1.0 2.2 0.9
Number of full sisters 0.5 0.7 1.4 0.8 0.8 0.7 -0.5 1.2 0.9 0.5
Suffer from ‘nerves’ 0.6 1.0 4.8 -0.5 -0.4 -0.4 -0.1 -2.2 -0.5 -1.1
Overall health rating 0.1 0.3 0.9 -0.4 0.3 -0.7 1.0 0.1 0.6 -0.2
Chest pain or discomfort 0.3 0.4 0.9 -1.0 -0.3 -0.6 -0.4 -1.0 0.1 -0.4
Had major operations 0.6 0.8 2.9 -0.6 -0.7 -0.8 0.8 1.7 0.2 0.5
Age at last live birth 0.8 1.1 3.7 -1.3 -1.9 -0.4 0.1 -0.1 -0.8 -1.3
Family relationship satisfaction 1.0 1.3 3.6 -0.9 -0.0 -1.9 1.7 -0.6 0.9 -0.7
Leg pain on walking 0.6 0.7 1.5 -0.8 -0.6 -1.1 0.8 -0.8 0.1 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 3.1 -0.6 -1.1 -1.6 1.8 0.2 -0.8 -0.4
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 0.2 0.0 0.7 -0.0 0.4 -0.9 -0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.2 -0.5 -1.1 -0.7 -0.1 -1.4 -1.8 -1.0
Medication: Aspirin 2.4 3.2 4.1 -1.5 -1.7 -1.8 1.7 -1.8 -2.0 -2.0
Supplements: Vitamin C 1.6 1.9 4.0 2.0 1.7 1.3 -1.1 1.0 1.0 1.5
Knee pain experienced in last month 0.8 1.2 3.7 1.0 0.8 0.3 -0.1 1.5 0.9 1.9
Hypertension (Self-reported) 0.4 1.2 2.5 -0.7 -1.3 -1.0 1.5 1.6 -0.1 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 2.2 -1.3 -1.3 -1.5 1.4 -0.8 -1.2 -1.5
Illnesses of father: Heart disease 0.4 0.6 1.7 -0.5 -0.9 -0.6 0.3 0.9 -1.3 0.0
Illnesses of siblings: Diabetes 4.3 5.3 15.0 -2.1 -1.2 -3.9 3.0 -2.2 -1.1 -1.3
Smoking status: Previous 2.4 3.6 9.5 -1.9 -2.3 -3.1 1.9 0.2 -1.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 5.6 0.9 1.2 0.6 0.3 2.4 0.9 1.1
Whole body fat-free mass 0.9 5.3 11.2 -2.2 -2.0 -3.4 3.2 2.1 -1.4 -0.0
Leg fat-free mass (right) 1.4 7.7 19.5 -3.1 -2.3 -4.4 3.7 1.6 -1.7 -0.5
Arm fat percentage (left) 3.5 13.8 39.6 -4.2 -3.2 -6.3 4.4 -0.8 -2.8 -1.2
Average weekly red wine intake 1.4 2.1 4.7 1.6 1.8 0.5 -1.1 0.7 2.2 1.6
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.2 -0.5 -1.0 -0.4 1.0 -1.1 -0.9 -1.5
Mood swings 0.7 1.3 3.5 -0.3 0.5 -1.8 1.9 -0.8 1.1 -0.6
Loneliness, isolation 1.2 1.6 3.2 -1.8 -1.7 -1.8 1.0 -0.1 -1.1 -0.5
Long-standing illness, disability or infirmity 0.3 0.5 1.1 -0.6 -0.8 -0.8 1.1 0.7 -0.1 0.3
Ever had bowel cancer screening 0.7 0.8 1.4 0.9 0.6 1.2 -1.0 -0.4 1.1 0.8
Diabetes diagnosed by doctor 1.6 2.5 7.3 -1.6 -1.4 -2.7 2.1 -0.4 -1.0 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.9 -0.4 0.3 -0.1 0.1 -1.4 1.1 -0.8
Friendships satisfaction 4.9 6.1 8.6 2.3 2.9 2.4 -2.7 0.9 2.9 2.4
Qualifications: nursing, teaching 0.2 0.4 0.8 -0.4 -0.1 0.9 -0.7 0.9 0.5 -0.5
Commuting to job workplace: Walk 0.1 0.1 0.4 -0.3 0.2 -0.2 0.6 0.1 0.6 -0.4
Eye problems/disorders: Cataract 0.5 0.5 1.6 -1.1 -0.3 -0.7 0.5 0.2 0.3 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.6 0.9 1.1 0.7 -0.0 0.8 1.3 0.9
Medication for cholesterol 0.9 1.4 2.6 1.0 1.6 1.6 -1.6 0.2 1.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 1.3 0.9 1.1 -0.2 0.7 0.3 0.2
Back pain experienced in last month 0.8 1.2 4.0 0.9 0.3 2.0 -1.5 1.0 -0.5 0.5
Mineral and other dietary supplements 0.3 0.5 1.3 -0.7 -0.1 -0.6 1.1 0.6 -0.5 -0.6
Breast cancer (self-reported) 0.1 0.1 0.4 -0.4 -0.7 -0.1 -0.6 0.3 -0.0 0.3
Asthma (self-reported) 3.2 6.4 13.8 -2.3 -2.8 -3.7 3.4 0.7 -1.8 -1.7
Osteoporosis (self-reported) 0.6 0.8 2.3 -1.1 -1.1 0.0 0.6 -0.3 -0.6 -1.5
Osteoarthritis (self-reported) 0.2 0.3 1.1 1.0 0.4 0.2 -0.0 0.4 0.4 0.9
Medication: Aspirin 1.6 2.1 2.6 -1.2 -1.3 -1.5 1.5 -1.5 -1.6 -1.5
Medication: Gliclazide 0.2 0.2 0.5 -0.2 -0.4 -0.5 0.6 0.1 -0.7 0.5
Illnesses of father: None of the above (group 1) 0.5 0.6 1.5 0.1 0.3 0.8 -1.2 0.4 1.2 0.1
Smoking status: Current 0.3 0.4 1.3 -0.3 0.1 -1.1 1.1 0.5 0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.5 5.7 2.2 1.8 2.2 -2.4 0.5 1.5 1.8
Whole body water mass 0.9 5.2 11.4 -2.2 -2.0 -3.4 3.1 2.1 -1.4 -0.0
Leg predicted mass (right) 1.4 7.5 18.4 -3.1 -2.3 -4.3 3.7 1.6 -1.7 -0.5
Arm fat mass (left) 3.3 13.5 37.1 -3.9 -3.3 -6.1 4.8 0.3 -2.8 -0.8
Number of self-reported non-cancer illnesses 3.6 6.2 10.7 -2.7 -3.1 -3.3 2.9 -1.3 -1.5 -1.9
Average weekly champagne plus white wine intake 0.3 0.4 2.0 0.0 0.6 0.3 0.0 0.3 1.4 -0.4
Miserableness 0.3 0.6 1.6 0.6 0.8 1.0 -0.1 0.5 1.3 0.2
Guilty feelings 0.2 0.3 1.1 0.5 0.3 -0.2 1.1 -0.5 0.3 0.1
Wears glasses or contact lenses 0.4 0.4 1.7 -0.1 -0.3 1.1 -1.3 0.0 -0.2 -0.1
Ever taken oral contraceptive pill 1.3 1.5 2.4 -0.4 -1.5 -1.1 1.6 0.3 -1.5 -1.4
Hearing aid user 0.9 1.0 2.7 0.4 -0.2 0.7 -1.2 1.5 -0.6 1.6
Mother’s age at death 1.0 1.3 3.9 0.2 -0.7 1.7 -2.0 -0.3 -0.9 -0.6
Financial situation satisfaction 3.0 3.7 8.1 -2.8 -1.5 -2.7 1.1 -1.0 -0.8 -2.2
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.4 0.1 0.5 -0.1 -0.3 -0.8 1.2 0.8
Commuting to job workplace: Public transport 0.4 0.5 1.5 -0.5 -1.0 -0.4 0.7 1.2 0.6 -0.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 -0.6 0.2 -0.3 0.3 -1.0 0.3 -0.9
Medication: Blood pressure 0.9 1.7 3.4 -1.5 -1.5 -1.6 1.9 1.0 -0.7 -0.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 0.5 0.8 0.2 0.0 0.3 0.9 0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 -0.2 0.4 -0.4 -0.6 0.4 0.7
High cholesterol (Self-reported) 3.1 5.5 6.8 -2.2 -2.5 -2.2 2.3 -2.6 -2.1 -2.5
Medication: Bendroflumethiazide 0.6 1.0 2.0 -1.1 -1.4 -0.9 0.7 0.1 -1.3 -0.6
Medication: Paracetamol 0.9 1.5 3.5 1.9 1.2 0.7 0.2 0.9 1.2 1.6
Medication: Lisinopril 0.9 1.1 4.9 -0.1 -0.3 -1.0 2.2 -1.0 0.0 -0.8
Medication: Atorvastatin 0.3 0.3 0.9 0.4 0.9 -0.6 0.6 -0.5 0.4 0.1
Illnesses of father: High blood pressure 1.2 1.4 3.9 -0.7 -0.7 -1.7 2.0 -1.0 -0.9 -0.6
Alcohol drinker status: Never 1.0 1.2 2.8 1.0 1.2 0.7 -0.8 -1.7 1.0 0.8
Ever smoked 1.3 2.2 6.0 -1.5 -1.6 -2.5 1.5 1.3 -0.8 0.4
Basal metabolic rate 1.3 7.0 16.5 -2.7 -2.3 -4.1 3.6 1.9 -1.7 -0.2
Leg fat percentage (left) 2.3 8.3 22.9 -2.5 -2.7 -4.8 4.0 0.3 -2.2 -0.5
Arm fat-free mass (left) 0.9 4.6 9.4 -1.7 -2.0 -2.9 3.1 2.3 -1.3 0.3
Number of operations (self-reported) 0.5 0.7 1.6 -0.7 -0.7 -1.0 1.2 1.2 0.3 0.4
Average weekly beer plus cider intake 1.2 1.7 3.7 0.1 0.4 -1.3 1.7 1.9 1.5 1.2
Irritability 0.9 1.6 4.3 -1.2 -0.6 -2.0 2.1 -0.0 0.0 -1.1
Risk taking 0.5 0.7 2.5 -0.4 -0.6 -0.4 1.0 1.6 -0.0 0.8
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.5 1.2 1.2 -0.5 0.6 1.4 1.9 1.1
Fractured/broken bones in last 5 years 1.6 2.0 4.6 -1.7 -2.2 -1.2 1.4 -0.0 -1.2 -1.3
Age started oral contraceptive pill 0.6 0.7 1.7 0.5 0.6 1.3 -1.3 -0.7 0.6 0.2
Diastolic blood pressure, automated reading 0.3 0.9 1.6 0.5 -1.2 -0.5 1.1 1.2 -0.5 1.3
Ever depressed for a whole week 1.0 1.2 3.0 -1.2 -1.2 -0.2 -0.2 -1.7 -0.7 -1.5
Unable to work because of sickness or disability 0.6 0.7 1.8 -1.1 -1.0 -0.4 0.1 -1.3 -0.5 -0.8
Commuting to job workplace: Cycle 1.3 1.6 3.1 -1.7 -1.3 -0.9 0.4 -1.0 -1.1 -1.8
Myopia 1.3 1.9 11.2 -0.0 0.4 0.1 0.1 3.3 0.9 1.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 2.2 0.7 1.2 0.7 -1.3 -1.5 0.4 0.2
Cholesterol lowering medication 2.0 3.0 5.8 -1.9 -2.2 -1.5 0.3 -2.4 -1.4 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 3.5 -1.2 0.1 -1.3 1.5 -1.7 0.2 -1.9
Pain experienced in last month 0.5 0.8 2.6 -0.8 -1.6 -0.7 0.5 0.7 -1.1 -0.2
Supplements: Calcium 1.8 2.0 6.9 1.1 0.6 2.3 -2.6 -0.1 -0.0 0.7
Basal cell carcinoma (self-reported) 0.7 0.8 2.5 -0.5 -0.6 -1.2 1.6 -0.3 -0.5 -0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.0 -0.5 -1.3 -0.6 -0.2 -0.0 -1.7 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 6.5 -0.1 0.6 -0.2 -0.2 -2.6 0.2 -1.5
Heart disease (siblings) 1.5 1.8 3.5 -1.1 -1.1 -1.1 1.0 -1.6 -1.3 -1.9
Alcohol drinker status: Previous 0.5 0.5 1.1 -0.5 -0.7 -0.5 1.0 -0.6 -0.9 -0.6
Pack years of smoking 0.5 0.8 1.3 -0.8 -1.2 -1.0 0.9 0.9 -0.8 0.7
Impedance of whole body 1.5 7.6 13.2 3.2 3.6 3.3 -2.5 -0.7 3.0 1.8
Leg fat mass (left) 2.7 10.4 28.8 -3.1 -3.1 -5.4 4.3 0.7 -2.4 -0.4
Arm predicted mass (left) 1.0 5.1 11.4 -1.8 -2.1 -3.1 3.4 2.2 -1.4 0.1