Best TWAS P=7.51e-15 · Best GWAS P=1.94e-13 conditioned to 1.89e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -7.1 | 7.8 | 7.5e-15 | 0.31 | 0.04 | 0.90 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | ACSM5 | 0.14 | 0.00 | lasso | 8 | 0.02 | 6.4e-03 | 5.8 | -5.3 | 1.2e-07 | -0.50 | 0.05 | 0.74 | FALSE |
| 3 | GTEx | Adrenal Gland | KNOP1 | 0.40 | 0.34 | lasso | 4 | 0.40 | 1.1e-15 | -5.3 | -5.2 | 2.5e-07 | -0.22 | 0.94 | 0.06 | FALSE |
| 4 | GTEx | Adrenal Gland | AC002550.5 | 0.37 | 0.39 | enet | 28 | 0.40 | 1.6e-15 | -4.6 | -5.2 | 2.1e-07 | -0.22 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Aorta | KNOP1 | 0.50 | 0.48 | lasso | 8 | 0.49 | 4.0e-30 | -4.6 | -5.4 | 8.2e-08 | -0.22 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Aorta | AC002550.5 | 0.52 | 0.52 | lasso | 7 | 0.49 | 1.9e-30 | -4.6 | -5.2 | 1.6e-07 | -0.22 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Coronary | KNOP1 | 0.28 | 0.25 | lasso | 7 | 0.32 | 2.5e-11 | -4.6 | -5.4 | 6.1e-08 | -0.22 | 0.42 | 0.58 | FALSE |
| 8 | GTEx | Artery Coronary | AC002550.5 | 0.30 | 0.34 | enet | 11 | 0.37 | 1.5e-13 | -4.6 | -5.3 | 1.4e-07 | -0.22 | 0.87 | 0.13 | FALSE |
| 9 | GTEx | Brain Frontal Cortex BA9 | KNOP1 | 0.43 | 0.33 | lasso | 14 | 0.30 | 1.0e-08 | -4.6 | -5.1 | 3.0e-07 | -0.20 | 0.95 | 0.01 | FALSE |
| 10 | GTEx | Brain Putamen basal ganglia | AC002550.5 | 0.59 | 0.48 | enet | 23 | 0.58 | 1.2e-16 | -4.6 | -5.7 | 1.1e-08 | -0.19 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | AC002550.5 | 0.37 | 0.49 | enet | 13 | 0.50 | 3.3e-29 | -4.6 | -5.3 | 1.4e-07 | -0.22 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Male) | AC002550.5 | 0.37 | 0.29 | lasso | 3 | 0.35 | 4.8e-09 | -6.0 | -5.9 | 4.6e-09 | -0.22 | 0.29 | 0.68 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Female) | AC002550.5 | 0.36 | 0.26 | enet | 19 | 0.33 | 1.3e-10 | -5.3 | -5.4 | 6.1e-08 | -0.23 | 0.83 | 0.16 | FALSE |
| 14 | GTEx | Colon Sigmoid | KNOP1 | 0.32 | 0.35 | lasso | 6 | 0.32 | 4.9e-12 | -4.6 | -5.4 | 6.4e-08 | -0.21 | 0.64 | 0.36 | FALSE |
| 15 | GTEx | Colon Transverse | KNOP1 | 0.22 | 0.23 | enet | 19 | 0.24 | 9.8e-12 | -4.6 | -5.5 | 2.9e-08 | -0.27 | 0.89 | 0.11 | FALSE |
| 16 | GTEx | Colon Transverse | AC002550.5 | 0.35 | 0.36 | enet | 15 | 0.41 | 5.0e-21 | -4.6 | -5.6 | 2.6e-08 | -0.21 | 0.98 | 0.02 | FALSE |
| 17 | GTEx | Esophagus Gastroesophageal Junction | KNOP1 | 0.51 | 0.44 | enet | 22 | 0.56 | 5.3e-24 | -5.3 | -6.0 | 2.7e-09 | -0.27 | 0.53 | 0.47 | FALSE |
| 18 | GTEx | Esophagus Gastroesophageal Junction | AC002550.5 | 0.62 | 0.54 | enet | 35 | 0.63 | 4.4e-29 | -4.4 | -6.0 | 1.6e-09 | -0.27 | 0.98 | 0.02 | FALSE |
| 19 | GTEx | Liver | KNOP1 | 0.23 | 0.21 | lasso | 7 | 0.25 | 1.4e-07 | -4.4 | -5.7 | 1.1e-08 | -0.27 | 0.78 | 0.08 | FALSE |
| 20 | GTEx | Liver | AC002550.5 | 0.43 | 0.42 | enet | 13 | 0.47 | 1.1e-14 | -4.4 | -5.5 | 4.8e-08 | -0.24 | 0.98 | 0.02 | FALSE |
| 21 | GTEx | Lung | GPRC5B | 0.08 | 0.05 | lasso | 4 | 0.06 | 2.4e-05 | -4.4 | 5.2 | 2.2e-07 | 0.23 | 0.91 | 0.01 | FALSE |
| 22 | GTEx | Ovary | KNOP1 | 0.61 | 0.64 | lasso | 7 | 0.57 | 4.4e-17 | -4.6 | -5.2 | 2.4e-07 | -0.20 | 0.96 | 0.04 | FALSE |
| 23 | GTEx | Pancreas | KNOP1 | 0.42 | 0.37 | lasso | 11 | 0.40 | 4.2e-18 | -4.4 | -5.4 | 5.6e-08 | -0.20 | 0.93 | 0.07 | FALSE |
| 24 | GTEx | Pancreas | AC002550.5 | 0.37 | 0.36 | lasso | 12 | 0.36 | 3.2e-16 | -4.6 | -5.2 | 2.2e-07 | -0.23 | 0.99 | 0.01 | FALSE |
| 25 | GTEx | Skin Not Sun Exposed Suprapubic | AC002550.5 | 0.44 | 0.43 | enet | 24 | 0.43 | 1.2e-25 | -4.4 | -5.5 | 4.1e-08 | -0.20 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Stomach | KNOP1 | 0.28 | 0.21 | lasso | 6 | 0.21 | 1.8e-10 | -3.8 | -5.2 | 1.9e-07 | -0.22 | 0.48 | 0.52 | FALSE |
| 27 | GTEx | Vagina | KNOP1 | 0.43 | 0.35 | lasso | 5 | 0.36 | 4.2e-09 | -4.6 | -5.2 | 1.7e-07 | -0.24 | 0.86 | 0.12 | FALSE |
| 28 | GTEx | Whole Blood | KNOP1 | 0.08 | 0.04 | lasso | 3 | 0.04 | 1.7e-04 | -4.6 | -5.7 | 1.0e-08 | -0.22 | 0.73 | 0.21 | FALSE |
| 29 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQCK | 0.05 | 0.02 | blup | 73 | 0.03 | 1.0e-03 | -6.1 | -5.5 | 2.8e-08 | -0.22 | 0.06 | 0.82 | FALSE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCK | 0.03 | 0.03 | blup | 73 | 0.03 | 1.6e-07 | -4.4 | -5.5 | 4.8e-08 | -0.24 | 0.77 | 0.23 | FALSE |
| 31 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IQCK | 0.04 | 0.03 | lasso | 2 | 0.04 | 7.5e-05 | -4.6 | -5.5 | 5.1e-08 | -0.29 | 0.23 | 0.28 | FALSE |
| 32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C16orf88 | 0.07 | 0.05 | lasso | 2 | 0.05 | 7.7e-04 | -5.3 | -5.3 | 1.3e-07 | -0.24 | 0.00 | 0.90 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C16orf88 | 0.10 | 0.10 | lasso | 3 | 0.13 | 3.7e-14 | -5.3 | -5.3 | 1.1e-07 | -0.22 | 0.01 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -6.1 | -6.4 | 1.3e-10 | -0.25 | 0.03 | 0.93 | FALSE |
| 35 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C16orf88 | 0.34 | 0.21 | lasso | 4 | 0.17 | 3.1e-07 | -5.3 | -5.3 | 9.5e-08 | -0.24 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IQCK | 0.04 | 0.01 | blup | 73 | 0.01 | 1.8e-02 | -4.5 | -5.6 | 2.2e-08 | -0.23 | 0.08 | 0.33 | FALSE |
| 37 | The Cancer Genome Atlas | Thyroid Carcinoma | GPRC5B | 0.06 | 0.01 | blup | 38 | 0.01 | 2.4e-02 | -4.4 | -6.8 | 1.3e-11 | -0.43 | 0.01 | 0.08 | FALSE |