TWAS
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Usage
Models
Genes
Traits
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Traits
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Whole body fat-free mass
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chr21:36,744,868-38,140,262
Best TWAS P=1.77e-08 · Best GWAS P=4.14e-06 conditioned to 7.98e-05
36.8M
37M
37.2M
37.4M
37.6M
37.8M
38M
38.2M
0
1
2
3
4
5
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Colon Adenocarcinoma
CBR1
0.45
0.09
lasso
5
0.22
5.1e-13
2.9
-5.6
1.8e-08
0.00
0.02
0.86
TRUE
1
CommonMind
Brain Pre-frontal Cortex
CBR1
0.25
0.12
enet
29
0.20
9.5e-24
-4.4
-5.3
1.1e-07
0.00
0.02
0.92
TRUE
2
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
DOPEY2
0.05
0.01
blup
115
0.02
5.6e-03
-3.6
-5.1
2.6e-07
-0.13
0.01
0.05
TRUE