[Hub]/) : Traits : Whole body fat-free mass :

chr2:85,083,503-86,518,249

Best TWAS P=2.73e-13 · Best GWAS P=2.91e-12 conditioned to 0.0142

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RNF181 0.07 0.02 bslmm 476 0.03 3.4e-04 5.8 5.5 4.1e-08 0.59 0.02 0.91 FALSE
2 GTEx Adipose Subcutaneous GGCX 0.16 0.09 lasso 5 0.08 3.1e-07 5.4 5.3 1.5e-07 0.71 0.96 0.04 FALSE
3 GTEx Adipose Visceral Omentum GGCX 0.13 0.03 lasso 7 0.03 1.1e-02 5.5 5.2 1.7e-07 0.68 0.32 0.27 FALSE
4 GTEx Artery Aorta GGCX 0.23 0.22 lasso 6 0.23 5.5e-13 5.5 6.2 7.0e-10 0.74 0.91 0.09 FALSE
5 GTEx Artery Tibial GGCX 0.29 0.22 enet 14 0.24 6.3e-19 5.4 6.4 1.3e-10 0.69 0.96 0.04 FALSE
6 GTEx Brain Cerebellar Hemisphere GGCX 0.46 0.41 enet 16 0.48 5.3e-14 4.4 5.5 3.7e-08 0.72 0.95 0.05 FALSE
7 GTEx Brain Cerebellum GGCX 0.54 0.30 lasso 10 0.34 6.0e-11 5.4 6.2 7.4e-10 0.75 0.92 0.08 FALSE
8 GTEx Brain Cortex GGCX 0.38 0.17 enet 30 0.02 1.1e-01 4.4 5.4 5.6e-08 0.60 0.47 0.20 FALSE
9 GTEx Breast Mammary Tissue GGCX 0.14 0.01 lasso 3 0.01 1.0e-01 5.4 5.2 1.6e-07 0.69 0.13 0.11 FALSE
10 GTEx Breast Mammary Tissue (Male) GGCX 0.10 0.00 enet 4 0.00 3.3e-01 3.9 5.2 2.3e-07 0.69 0.06 0.09 FALSE
11 GTEx Cells EBV-transformed lymphocytes GGCX 0.36 0.31 enet 18 0.29 4.5e-10 4.2 5.4 6.0e-08 0.71 0.96 0.04 FALSE
12 GTEx Colon Transverse GGCX 0.26 0.28 lasso 3 0.28 1.4e-13 5.4 6.0 2.6e-09 0.73 0.94 0.06 FALSE
13 GTEx Esophagus Gastroesophageal Junction GGCX 0.24 0.16 lasso 6 0.12 4.3e-05 5.5 5.8 5.1e-09 0.74 0.37 0.40 FALSE
14 GTEx Esophagus Mucosa GGCX 0.29 0.21 enet 30 0.27 5.8e-18 5.7 5.6 2.3e-08 0.62 0.94 0.06 FALSE
15 GTEx Esophagus Mucosa TMEM150A 0.10 0.05 enet 5 0.05 3.2e-04 5.4 -5.7 1.6e-08 -0.80 0.07 0.88 FALSE
16 GTEx Esophagus Muscularis GGCX 0.14 0.12 lasso 9 0.12 1.1e-07 5.5 6.2 5.8e-10 0.75 0.61 0.39 FALSE
17 GTEx Lung GGCX 0.17 0.17 lasso 2 0.18 2.3e-13 5.5 5.5 4.9e-08 0.72 0.97 0.03 FALSE
18 GTEx Muscle Skeletal GGCX 0.10 0.04 enet 11 0.02 2.7e-03 5.5 6.3 2.2e-10 0.78 0.09 0.91 FALSE
19 GTEx Nerve Tibial GGCX 0.38 0.30 lasso 7 0.33 6.5e-24 5.4 6.4 1.3e-10 0.72 0.97 0.03 FALSE
20 GTEx Pancreas VAMP5 0.29 0.09 enet 4 0.05 3.2e-03 6.2 -6.9 6.0e-12 -0.66 0.02 0.76 FALSE
21 GTEx Skin Not Sun Exposed Suprapubic GGCX 0.13 0.04 enet 11 0.06 3.9e-04 5.4 6.6 4.9e-11 0.64 0.31 0.21 FALSE
22 GTEx Skin Sun Exposed Lower leg GGCX 0.15 0.11 lasso 3 0.18 7.9e-15 5.4 6.8 1.3e-11 0.69 0.78 0.22 FALSE
23 GTEx Testis GGCX 0.38 0.36 enet 25 0.40 8.6e-19 5.5 6.3 3.3e-10 0.72 0.82 0.18 FALSE
24 GTEx Thyroid GGCX 0.30 0.17 enet 10 0.23 1.4e-17 5.4 6.5 1.2e-10 0.74 0.95 0.05 FALSE
25 GTEx Whole Blood GGCX 0.15 0.14 lasso 4 0.15 1.7e-13 5.4 5.8 5.2e-09 0.73 0.96 0.04 FALSE
26 NTR Blood VAMP8 0.05 0.04 lasso 8 0.04 2.0e-12 5.0 -5.2 2.1e-07 -0.74 0.96 0.04 FALSE
27 YFS Blood VAMP8 0.15 0.15 enet 37 0.18 2.2e-55 5.7 -6.0 2.2e-09 -0.75 0.94 0.06 FALSE
28 The Cancer Genome Atlas Colon Adenocarcinoma C2orf68 0.06 0.06 lasso 2 0.05 1.1e-03 5.8 -5.7 1.0e-08 -0.88 0.02 0.68 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma GGCX 0.05 0.05 lasso 1 0.04 1.2e-05 5.5 5.5 5.1e-08 0.72 0.74 0.10 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma USP39 0.04 0.02 blup 67 0.03 2.0e-04 5.5 -5.3 1.1e-07 -0.76 0.08 0.81 FALSE
31 The Cancer Genome Atlas Lung Squamous Cell Carcinoma VAMP5 0.07 0.04 blup 44 0.05 2.1e-06 6.3 -5.5 3.0e-08 -0.49 0.14 0.74 FALSE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma VAMP8 0.06 0.01 enet 15 0.02 2.1e-02 6.3 6.3 2.9e-10 0.45 0.04 0.22 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma GGCX 0.04 0.02 blup 44 0.02 2.7e-03 6.2 7.3 2.7e-13 0.72 0.12 0.68 TRUE
34 The Cancer Genome Atlas Soft Tissue Sarcoma GGCX 0.04 0.03 lasso 2 0.03 1.1e-02 5.7 5.6 1.8e-08 0.70 0.06 0.06 FALSE
35 The Cancer Genome Atlas Thyroid Carcinoma GGCX 0.03 0.03 enet 5 0.02 8.7e-03 5.4 5.8 8.7e-09 0.82 0.05 0.54 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma VAMP8 0.04 0.05 lasso 3 0.05 1.2e-05 5.4 -5.4 7.3e-08 -0.77 0.36 0.48 FALSE