Hub : Genes

USP39

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1800	0.0800	6.5e-03	0.095	NA	0.071	NA	0.067	2.2e-06	NA	4.0e-05	NA	6.9e-05
2	GTEx	Muscle Skeletal	0.1833	0.0483	9.6e-06	0.101	NA	0.056	NA	0.096	4.2e-10	NA	3.2e-06	NA	1.1e-09
3	GTEx	Ovary	0.3960	0.1060	7.2e-04	0.020	NA	0.025	NA	0.046	1.0e-01	NA	8.0e-02	NA	2.8e-02
4	GTEx	Testis	0.2580	0.0810	2.1e-03	-0.005	NA	-0.006	NA	-0.006	6.3e-01	NA	8.9e-01	NA	9.7e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.3396	0.0403	0.0e+00	0.307	0.252	0.327	0.301	0.326	3.5e-40	4.3e-32	4.0e-43	3.6e-39	5.7e-43
6	TCGA	Bladder Urothelial Carcinoma	0.0420	0.0240	4.4e-03	0.001	0.015	-0.002	NA	-0.002	2.7e-01	1.8e-02	5.2e-01	NA	5.2e-01
7	TCGA	Breast Invasive Carcinoma	0.0168	0.0096	3.8e-03	0.001	0.011	0.003	NA	0.004	1.5e-01	1.7e-03	6.9e-02	NA	5.2e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1187	0.0407	1.4e-07	0.079	0.063	0.062	NA	0.083	2.9e-09	1.3e-07	1.5e-07	NA	1.4e-09
9	TCGA	Brain Lower Grade Glioma	0.0732	0.0300	2.5e-05	0.053	0.028	0.042	NA	0.046	1.2e-06	3.5e-04	1.4e-05	NA	5.2e-06
10	TCGA	Liver Hepatocellular Carcinoma	0.1030	0.0500	2.5e-03	0.072	0.038	0.036	NA	0.026	2.9e-04	7.1e-03	8.4e-03	NA	2.2e-02
11	TCGA	Lung Adenocarcinoma	0.0371	0.0174	3.4e-04	0.023	0.029	0.021	NA	0.020	9.6e-04	2.0e-04	1.4e-03	NA	1.7e-03
12	TCGA	Prostate Adenocarcinoma	0.0863	0.0298	1.4e-08	0.118	0.084	0.098	NA	0.110	2.6e-12	3.9e-09	2.2e-10	NA	1.5e-11
13	TCGA	Thyroid Carcinoma	0.1460	0.0420	1.9e-08	0.073	0.096	0.105	NA	0.106	1.3e-07	1.3e-09	2.1e-10	NA	1.7e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.6	1.0	2.4	-1.5	-1.4	-0.9	-0.2	-1.2	0.0	0.1	-1.4	-1.1	-0.2	0.5	-1.0	-1.4
Bipolar Disorder or Schizophrenia	0.5	1.3	2.6	-0.6	-1.5	-1.3	-0.7	-1.3	-1.1	-1.2	-1.2	-1.3	-0.2	-0.6	-1.6	-1.2
Depressed Affect (Nagel 2018)	0.3	0.6	4.0	0.5	0.6	-2.0	0.9	0.5	0.1	0.9	0.3	0.8	0.3	0.1	0.4	0.6
Depression (Nagel 2018)	0.2	0.3	2.0	-0.1	0.2	0.6	1.4	-0.1	0.4	0.3	-0.4	0.1	0.4	0.4	-0.3	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	-1.3	0.4	-1.0	-0.3	0.1	0.9	1.5	-0.3	0.3	0.2	1.1	0.6	-0.2
Neuroticism (Nagel 2018)	0.2	0.4	4.1	-0.3	0.1	-2.0	0.4	0.1	-0.1	0.5	-0.1	0.3	-0.5	-0.3	0.3	0.1
Schizophrenia (2018)	0.4	0.9	2.4	0.5	-0.7	-0.9	-0.8	-0.8	-1.5	-1.6	-0.4	-0.8	-0.0	-1.2	-1.2	-0.4
Schizophrenia vs Biploar Disorder	2.3	3.0	6.8	2.2	2.6	1.0	0.4	2.1	0.6	1.1	2.2	1.7	1.8	0.6	2.0	2.3
Worry (Nagel 2018)	0.2	0.4	2.0	-1.4	0.2	-1.1	0.6	-0.4	0.2	0.4	-0.8	-0.4	-0.6	0.1	0.1	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	3.5	-0.2	0.3	-1.9	-0.3	0.2	-0.4	-0.0	0.2	0.3	-0.5	-0.8	0.3	-0.0
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.6	-0.9	-0.2	0.9	-0.6	0.2	-0.6	-0.6	-0.7	0.5	0.2	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	3.7	-0.4	-0.4	-1.9	0.4	-0.3	-0.4	-0.6	-0.3	-0.4	-0.3	-0.8	-0.2	-0.5
Crohns Disease (2017)	0.6	1.3	2.5	-0.4	-1.3	-0.7	-0.7	-1.4	-1.2	-1.5	-1.2	-1.4	-0.7	-1.1	-1.6	-1.2
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	-0.1	-0.8	-0.2	-0.3	-1.0	-1.3	-1.5	-0.7	-1.2	-0.7	-1.4	-1.0	-0.8
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.1	-0.3	0.7	0.1	-0.4	-0.9	-1.1	-0.1	-0.7	-0.1	-1.2	-0.2	-0.3
Major Depression (MDD)	1.8	2.2	3.5	-1.2	-1.5	-0.4	1.4	-1.7	-1.5	-1.1	-1.6	-1.6	-1.9	-1.3	-1.6	-1.8
Reaction Time	0.3	0.6	2.5	-0.0	-0.3	1.6	1.5	-0.7	-0.4	-0.7	-0.6	-0.7	-0.3	-0.3	-0.8	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	2.5	-1.6	-0.2	-0.3	0.0	-0.3	0.4	0.6	-0.5	-0.3	0.2	0.6	0.3	-0.7
Breast Cancer	0.3	0.7	1.5	0.3	1.2	0.4	-0.8	1.0	0.8	0.3	0.9	1.0	0.6	-0.1	1.2	1.1
Ovarian Cancer	0.4	0.6	2.0	0.7	-0.0	-0.8	-1.4	-0.1	-0.8	-1.3	0.1	-0.3	0.0	-1.3	-0.5	0.2
Prostate Cancer	14.5	20.4	47.1	0.4	2.9	3.3	3.4	4.0	6.2	5.9	3.2	4.3	6.3	6.9	4.3	3.2
Age at First Birth	0.4	0.6	2.0	-0.8	0.7	-1.1	0.4	0.2	0.8	1.2	-0.0	0.3	0.3	1.4	0.7	0.0
Bipolar Disorder (2011)	0.8	0.8	2.0	-1.4	-1.0	-0.1	0.5	-0.9	0.5	0.6	-1.2	-0.7	0.0	1.3	-0.8	-1.1
Body Mass Index (BMI) (2010)	0.4	0.6	2.6	0.6	-0.6	-1.6	-0.8	0.1	-0.8	-1.1	0.4	-0.1	-0.2	-1.1	-0.3	0.2
Coronary Artery Disease (CAD)	5.2	6.2	11.7	-0.4	-3.1	-0.8	-2.7	-2.4	-3.0	-3.4	-2.0	-2.8	-1.7	-3.1	-2.7	-2.1
Crohns Disease (2012)	0.3	0.5	3.5	0.7	-0.0	-1.9	-0.1	0.1	-0.6	-0.5	0.4	0.1	-0.7	-0.7	-0.2	0.2
Mean Putamen Volume	0.5	0.5	1.2	0.5	1.0	-0.8	-1.1	0.7	0.5	0.1	0.8	0.7	0.9	0.3	0.8	0.8
Fasting Glucose	0.2	0.2	1.0	-0.0	0.4	-0.7	-0.5	0.4	0.4	1.0	0.1	0.4	-0.1	0.6	0.4	0.2
HbA1C	0.1	0.2	1.0	-0.2	0.1	-0.0	-1.0	-0.1	0.3	0.6	-0.4	-0.1	-0.3	0.4	-0.5	-0.1
HDL Cholesterol	0.2	0.4	1.3	0.5	0.2	1.2	-0.0	0.7	0.7	0.0	0.9	0.5	0.7	0.1	0.8	0.6
LDL Cholesterol	1.7	2.8	5.4	0.7	2.2	-0.7	0.8	1.9	1.5	2.3	1.8	2.1	0.9	1.5	2.2	1.7
Lupus	0.8	1.2	6.8	-0.1	0.9	0.5	2.6	0.8	1.2	1.1	0.5	1.1	1.1	1.1	0.7	0.7
Neuroticism (2016)	1.5	2.2	6.1	1.1	-1.0	-0.7	-0.6	-1.2	-2.4	-2.1	-0.7	-1.4	-1.6	-2.5	-1.6	-0.8
Primary Biliary Cirrhosis	0.5	0.8	1.9	-0.3	-0.8	0.4	-0.2	-0.8	-1.4	-0.8	-0.8	-0.7	-1.4	-1.2	-0.9	-0.8
Rheumatoid Arthritis	1.8	2.5	9.4	3.1	1.0	0.8	1.6	1.8	0.9	0.3	2.2	1.5	1.5	0.3	1.2	2.0
Schizophrenia (2014)	0.3	0.8	2.5	-0.1	-0.8	-1.0	-1.6	-0.8	-1.0	-1.0	-0.6	-0.8	-0.1	-0.8	-1.0	-0.6
Triglycerides	0.3	0.5	2.0	-1.2	-0.3	-0.6	-1.4	-0.6	-0.1	0.3	-0.8	-0.3	-0.7	0.2	-0.4	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.1	0.4	0.2	-1.1	0.6	-0.2	-0.6	-0.1	-0.3	-0.2	-0.2	-0.4	-0.5	-0.1
Ulcerative Colitis	0.1	0.2	0.4	0.5	0.2	0.2	0.7	0.3	-0.6	-0.3	0.5	0.0	-0.4	-0.6	0.4	0.4
Blood Eosinophil Count	1.3	10.2	21.1	1.9	3.9	2.6	3.5	3.4	2.5	4.6	2.8	3.8	1.3	3.0	3.5	3.2
Blood Platelet Count	0.9	10.1	41.0	2.4	2.9	-6.4	-5.0	0.9	-3.7	-1.1	1.4	0.4	-3.6	-4.1	1.1	1.2
Blood Red Count	0.1	1.4	5.0	0.1	1.6	0.3	-0.5	1.3	0.4	2.2	1.0	1.4	0.2	1.2	1.7	0.9
Blood White Count	2.1	15.3	26.8	1.4	5.2	3.8	1.6	4.0	4.2	4.8	3.2	4.3	3.7	4.4	4.4	3.9
Heel T-Score	1.4	11.0	16.6	1.0	4.1	2.0	3.1	3.6	4.0	4.1	3.0	3.7	2.5	3.3	4.0	3.3
BMI	0.1	0.8	1.4	-1.2	-1.2	0.3	-0.6	-1.0	-0.6	-0.5	-1.1	-0.7	-1.1	-0.5	-1.0	-0.9
Height	1.8	35.4	69.9	0.5	-6.9	-3.6	-3.4	-5.2	-8.0	-8.1	-3.9	-5.3	-7.3	-8.4	-6.7	-4.4
Waist Hip Ratio (WHR)	0.4	1.7	7.3	-1.2	0.4	1.4	2.0	-0.1	1.2	2.1	-0.4	-0.0	0.9	2.7	0.5	-0.4
Systolic Blood Pressure	0.2	1.1	3.0	-1.1	0.2	-1.7	-1.7	-0.5	0.8	0.8	-0.7	-0.5	1.2	1.6	-0.2	-0.7
Smoking Status	0.3	0.7	3.2	1.8	0.7	0.3	1.2	0.8	-0.0	-0.2	1.0	0.8	0.6	-0.1	0.2	1.2
Allergy or Eczema	0.8	2.2	7.0	-2.6	-0.9	2.2	1.0	-1.6	-0.3	0.3	-1.9	-1.5	-1.6	0.0	-0.8	-1.9
Cardiovascular Disease	0.4	1.2	3.7	-1.9	-0.5	-1.0	-1.2	-1.2	-0.1	0.7	-1.6	-1.0	-0.3	1.2	-0.8	-1.4
Hypothyroidism (self reported)	0.7	1.6	6.9	-0.7	-1.1	2.6	2.5	-0.9	0.3	-0.7	-1.0	-1.0	0.5	0.3	-1.0	-0.9
Respiratory disease	0.2	0.4	1.8	-1.1	0.2	1.4	-0.2	-0.2	0.2	0.8	-0.5	-0.0	-0.3	0.6	0.0	-0.3
Type 2 Diabetes (T2D) (2018)	2.2	4.2	7.9	-0.3	2.3	2.8	1.8	1.7	2.6	2.5	1.2	1.8	1.5	2.8	2.2	1.3
Lung FEV1/FVC ratio	0.2	0.9	5.2	-0.5	-0.2	-2.3	0.0	-0.8	-0.5	-1.4	-0.6	-1.1	-0.1	-1.0	-0.4	-0.7
Lung FVC	0.3	1.7	4.9	1.3	1.3	2.2	1.7	1.4	0.1	-0.0	1.5	1.2	0.5	-0.7	1.3	1.5
Neuroticism	0.2	0.5	2.3	-0.1	0.9	-1.5	0.8	0.5	0.3	1.1	0.2	0.7	-0.1	0.1	0.7	0.4
Chronotype (morning person)	0.1	0.3	0.9	0.1	0.1	-0.9	-0.5	-0.2	-0.8	-0.1	-0.2	-0.3	-0.9	-0.8	-0.1	-0.2
Hair Pigment	0.1	3.7	7.8	-1.7	-1.9	-1.5	-0.0	-2.3	-2.0	-2.1	-2.0	-2.8	-1.7	-1.7	-1.6	-2.5
Tanning	0.3	3.7	7.2	2.2	2.3	1.0	-0.2	2.5	1.5	1.5	2.4	2.6	1.3	1.1	2.0	2.7
Hand grip strength (left)	0.7	1.9	4.4	0.8	-1.6	-0.6	-2.0	-0.8	-1.9	-2.1	-0.3	-0.8	-1.2	-2.1	-1.4	-0.4
Number of treatments/medications taken	0.5	0.9	3.1	-1.8	-0.0	-0.6	-0.2	-1.1	-0.5	0.6	-1.5	-1.0	-0.9	0.5	-0.4	-1.2
Average weekly spirits intake	2.7	3.4	6.9	-2.6	-1.7	-1.4	-0.9	-2.2	-1.2	-1.5	-2.2	-2.2	-1.6	-1.0	-1.7	-2.5
Sensitivity / hurt feelings	0.7	1.2	2.4	-1.0	-1.3	0.3	0.1	-1.4	-0.9	-0.6	-1.6	-1.3	-1.2	-0.7	-1.4	-1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.8	-0.6	-0.4	-1.3	0.6	-0.6	-0.0	-0.2	-0.8	-0.5	-0.2	-0.2	-0.6	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.6	-0.6	-0.7	-0.3	-0.6	-0.6	-0.3	-0.7	-0.3	-0.8	-0.5	-0.5	-0.6
Relative age of first facial hair	0.1	0.2	0.8	-0.1	-0.0	-0.2	0.2	-0.4	-0.9	-0.2	-0.3	-0.5	-0.5	-0.5	-0.2	-0.6
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	10.6	-1.6	-1.3	3.2	0.6	-1.6	-0.7	-0.9	-1.8	-1.6	-1.2	-0.7	-1.4	-1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.6	1.0	1.2	0.1	0.1	1.2	0.3	1.0	1.2	1.2	-0.2	0.2	1.3	1.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	-0.5	-1.3	0.1	0.0	-1.2	-1.2	-0.6	-1.0	-1.2	-1.2	-0.7	-1.2	-1.2
Systolic blood pressure, automated reading	0.3	0.8	4.7	-1.5	0.2	-1.2	-2.2	-0.4	0.4	0.6	-0.9	-0.3	0.0	0.7	0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	7.0	-2.6	-0.2	-0.4	-1.7	-0.8	-0.1	0.8	-1.1	-0.6	-0.8	0.6	-0.0	-1.3
Angina	7.1	9.4	14.8	-0.8	-3.2	-1.8	-2.0	-3.1	-3.7	-3.8	-2.5	-3.5	-3.9	-3.8	-3.2	-2.8
Medication for hormone replacement therapy	2.9	3.2	5.9	1.3	1.9	0.9	-0.2	2.2	1.7	2.2	2.0	2.4	1.3	1.4	2.1	2.1
Vitamin and mineral supplements	0.1	0.2	1.0	-0.5	0.0	0.5	-0.4	-0.2	-0.1	-0.3	-0.3	-0.1	-1.0	-0.6	-0.2	-0.2
Supplements: Zinc	0.3	0.3	1.3	1.1	0.4	1.1	-0.8	0.3	-0.5	-0.2	0.5	0.2	-0.0	-0.3	-0.0	0.5
Medication: Co-codamol	0.2	0.3	0.7	-0.5	-0.1	0.7	-0.1	-0.5	-0.8	-0.1	-0.4	-0.7	-0.7	-0.4	-0.1	-0.5
Medication: Metformin	0.3	0.4	2.4	-1.6	0.1	0.0	-0.9	-0.1	0.8	0.2	-0.2	-0.3	-0.0	0.5	0.6	-0.7
Diabetes (father)	0.5	0.6	1.8	-1.3	-0.6	-0.7	-0.9	-0.9	-0.1	-0.3	-0.9	-0.8	-1.1	-0.4	-0.5	-1.0
Diabetes (mother)	1.9	2.5	9.6	-1.3	1.2	3.1	1.9	0.5	2.0	2.0	0.2	0.7	1.4	2.1	1.1	0.1
Severe depression (siblings)	0.9	1.0	2.5	1.3	1.6	-0.5	0.1	1.2	0.2	0.7	1.3	1.4	0.0	-0.0	1.0	1.4
Pack years adult smoking proportion	0.2	0.3	1.1	0.8	-0.5	-1.1	0.0	-0.2	-0.5	-0.1	-0.1	0.0	-1.0	-0.5	-0.5	-0.0
Impedance of leg (right)	0.4	1.9	3.5	0.2	1.7	1.5	1.5	1.0	1.2	1.9	1.0	0.8	1.6	1.8	1.6	0.8
Leg fat-free mass (left)	2.1	10.9	22.8	0.2	-3.8	-2.6	-1.8	-2.8	-4.4	-4.4	-2.3	-2.5	-4.2	-4.8	-3.8	-2.2
Trunk fat percentage	1.3	5.2	10.2	-3.2	-2.0	-0.1	0.1	-2.8	-1.9	-1.6	-3.1	-2.8	-2.4	-1.6	-2.2	-3.0
Hand grip strength (right)	0.8	2.3	5.6	0.8	-1.7	-1.5	-2.1	-0.8	-1.8	-2.4	-0.2	-0.9	-1.4	-2.3	-1.4	-0.3
Townsend deprivation index at recruitment	0.5	0.7	2.0	-0.3	-0.9	1.4	0.6	-0.7	-0.8	-1.0	-0.7	-0.8	-0.9	-1.0	-0.8	-0.6
Current tobacco smoking	0.5	0.8	1.3	1.1	1.0	0.7	1.1	0.9	0.7	0.7	0.9	0.9	0.9	0.7	0.8	1.1
Average weekly fortified wine intake	0.2	0.3	1.0	0.1	1.0	-0.5	0.0	0.5	0.2	0.3	0.5	0.4	0.6	0.4	0.7	0.4
Maternal smoking around birth	1.2	1.7	3.7	0.1	-1.5	0.9	0.6	-1.2	-1.4	-1.6	-1.0	-1.2	-1.9	-1.8	-1.5	-0.9
Fed-up feelings	0.1	0.2	1.4	0.1	0.3	-1.2	0.4	-0.2	-0.7	0.1	-0.2	0.0	-0.4	-0.6	-0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	0.5	0.3	0.7	-0.0	-0.2	-0.2	-0.1	-0.1	0.0	-0.3	0.0	0.1
Relative age voice broke	0.4	0.6	1.9	-1.1	0.1	1.2	-0.1	-0.2	0.9	1.2	-0.4	-0.3	0.6	1.4	0.3	-0.6
Taking other prescription medications	1.4	2.1	5.5	-2.3	-1.5	0.1	1.8	-1.8	-0.0	-0.5	-2.1	-1.8	-0.2	0.2	-1.2	-2.0
Age when periods started (menarche)	0.3	0.8	4.2	2.0	0.4	-0.3	-1.0	0.9	-0.1	0.0	1.2	0.9	0.3	-0.1	0.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.8	1.7	0.5	-1.6	-0.3	0.2	-1.2	0.1	0.5	-0.0	-0.3	-0.1	-0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	4.2	9.6	12.4	2.3	3.3	2.6	2.6	3.4	3.3	3.2	3.1	3.5	2.9	2.9	3.3	3.4
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	4.5	0.6	2.1	0.8	0.7	1.6	1.3	1.5	1.5	1.6	1.6	1.3	1.8	1.7
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.7	-0.1	0.1	0.7	0.2	-0.2	-0.0	0.3	0.3	-0.1	-0.3	-0.1	0.4
Serious illness, injury or assault to yourself	0.4	0.5	3.7	0.4	0.3	-0.4	1.9	0.4	-0.2	0.9	0.3	0.6	-0.6	0.0	0.2	0.4
High blood pressure	0.5	1.4	4.5	-2.1	-0.9	-0.2	-0.9	-1.5	-0.6	-0.0	-1.8	-1.4	-0.9	0.3	-1.0	-1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.4	-2.1	-0.4	2.5	0.8	-1.1	0.0	0.4	-1.4	-1.1	-1.2	0.2	-0.5	-1.4
Multivitamins +/- minerals	0.6	0.8	1.7	0.8	1.1	-0.4	-0.6	0.9	0.6	1.1	0.9	0.8	1.3	1.1	0.9	0.9
Stomach or abdominal pain in last month	1.6	2.0	3.9	0.6	1.3	-0.4	1.1	1.5	2.0	2.0	1.4	1.5	1.4	1.7	1.6	1.2
Supplements: Glucosamine	0.3	0.4	2.3	-0.1	0.2	0.6	1.5	0.3	1.0	0.6	0.2	0.4	0.7	0.8	0.3	0.2
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	4.2	-1.5	-1.9	0.9	0.2	-2.0	-1.4	-1.6	-2.1	-2.0	-1.7	-1.1	-2.0	-2.0
Medication: Atenolol	1.9	2.3	3.8	-0.5	-1.8	-1.9	0.9	-1.6	-1.8	-1.1	-1.5	-1.6	-1.9	-1.3	-1.7	-1.5
Medication: Levothyroxine sodium	1.5	2.5	4.7	-2.0	-1.9	1.8	2.2	-1.7	-0.2	-0.9	-1.9	-1.6	-0.9	-0.1	-1.5	-1.8
Sitting height	0.8	6.0	16.5	4.0	-1.2	-4.1	-1.5	0.4	-3.2	-2.9	1.4	0.6	-1.8	-3.9	-1.2	1.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.1	-0.7	-0.0	0.7	-1.0	-0.3	-0.3	-1.2	-0.8	-1.0	-0.6	-0.7	-1.0
High blood pressure (mother)	3.2	4.5	13.8	-3.7	-2.8	-0.1	0.7	-2.5	0.7	0.0	-3.1	-2.2	-0.6	1.3	-2.0	-2.8
Body mass index (BMI)	0.7	3.0	5.7	-1.9	-1.8	-1.0	-0.7	-1.9	-1.6	-1.5	-2.1	-1.6	-2.4	-1.7	-1.8	-1.8
Impedance of leg (left)	0.5	2.3	3.5	0.9	1.9	1.7	1.5	1.4	1.2	1.8	1.4	1.0	1.8	1.7	1.8	1.2
Leg predicted mass (left)	2.1	11.3	23.0	0.2	-3.9	-2.6	-1.9	-2.9	-4.4	-4.5	-2.4	-2.6	-4.2	-4.8	-3.9	-2.3
Trunk fat mass	1.8	7.9	11.5	-2.6	-2.9	-1.1	-0.8	-3.2	-3.1	-2.7	-3.3	-3.1	-3.4	-2.8	-3.0	-3.1
Waist circumference	1.2	4.6	9.1	-1.9	-2.3	-0.9	-1.0	-2.4	-2.3	-1.8	-2.5	-2.2	-3.0	-2.0	-2.2	-2.3
Number of incorrect matches in round	0.7	1.1	4.6	1.1	-0.1	-0.4	-1.2	-0.2	-1.7	-1.7	0.2	-0.7	-0.9	-2.1	-0.3	-0.0
Past tobacco smoking	0.6	1.2	4.7	-2.0	0.3	-0.4	0.1	-0.0	1.2	2.2	-0.7	0.4	0.5	1.9	0.6	-0.6
Alcohol usually taken with meals	0.2	0.4	2.5	-1.6	-0.1	0.2	0.3	-0.4	-0.2	-0.4	-0.6	-0.3	-0.9	-0.5	0.1	-0.6
Nervous feelings	0.6	1.2	6.0	-2.4	-0.4	0.1	0.6	-0.8	1.1	1.0	-1.4	-0.6	-0.2	1.3	-0.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	-0.3	-0.4	-0.1	0.8	-0.8	-0.4	-0.6	-0.8	-0.9	-0.3	-0.4	-0.8	-0.6
Hearing difficulty/problems with background noise	0.3	0.5	2.5	-1.0	0.3	1.6	0.8	-0.5	-0.3	-0.0	-0.7	-0.5	-0.8	-0.2	0.1	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	1.5	0.5	-0.2	-1.2	-0.6	0.0	-0.2	-0.0	0.0	0.3	0.5	-0.0	-0.3	0.3
Had menopause	0.1	0.1	0.7	-0.5	-0.5	0.3	0.3	-0.1	0.8	0.0	-0.2	-0.0	0.5	0.3	-0.0	-0.2
Had other major operations	0.3	0.4	0.9	-0.4	-0.7	0.8	-0.2	-0.7	-1.0	-0.4	-0.6	-0.8	-0.4	-0.5	-0.5	-0.7
Forced vital capacity (FVC)	0.5	2.0	7.9	2.4	-0.4	0.5	-0.5	0.2	-2.2	-1.9	0.8	0.1	-1.2	-2.8	-0.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.8	15.6	3.3	3.7	1.4	2.6	3.8	2.7	3.5	3.7	3.9	2.9	2.8	3.5	4.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	0.6	1.2	0.2	1.2	0.9	0.6	1.2	0.8	0.9	0.1	0.5	1.0	0.9
Qualifications: None of the above	0.1	0.3	1.5	1.2	0.2	-0.2	0.6	0.2	-0.6	-0.2	0.5	0.3	-0.3	-0.7	-0.0	0.3
Financial difficulties in last 2 years	0.7	0.9	2.3	-0.1	-1.1	-1.1	-0.6	-0.8	-1.0	-1.2	-0.7	-0.9	-1.5	-1.1	-0.9	-0.7
Mouth/teeth dental problems	0.6	1.0	2.5	0.3	-1.6	0.3	0.1	-0.8	-0.8	-1.5	-0.7	-0.8	-1.1	-1.4	-1.2	-0.6
Heart attack	2.8	3.5	8.0	0.3	-1.8	-2.2	-1.7	-1.4	-2.6	-2.3	-0.9	-1.5	-2.4	-2.8	-1.7	-1.1
Allergy	0.6	1.4	7.4	2.7	0.4	-1.4	-0.6	1.0	-0.6	-1.0	1.5	0.8	0.9	-0.8	0.3	1.3
Pain all over the body in last month	0.5	0.6	1.3	-0.4	-1.0	0.6	0.5	-0.8	-0.4	-1.1	-0.7	-0.9	-0.3	-0.7	-1.0	-0.7
Diabetes (self-reported)	0.6	0.9	2.2	-0.9	1.1	1.1	0.5	0.5	1.3	1.5	0.2	0.6	0.0	1.4	1.1	0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	6.1	-2.5	-0.8	0.5	-0.7	-1.2	-0.3	1.0	-1.6	-1.1	-1.2	0.4	-0.5	-1.7
Medication: Ramipril	0.1	0.1	0.4	-0.3	0.3	0.3	0.3	-0.2	-0.7	0.1	-0.3	-0.3	-0.6	-0.4	0.0	-0.3
Medication: Simvastatin	0.2	0.2	0.9	-0.9	-0.1	-0.4	-0.7	-0.2	0.1	0.8	-0.4	-0.2	-0.3	0.6	0.2	-0.4
Fluid intelligence score	0.3	0.6	4.0	-2.0	-0.1	0.3	0.2	-0.4	0.7	0.9	-0.8	-0.3	-0.2	0.9	0.1	-0.8
Illnesses of siblings	0.8	1.2	3.6	-0.4	0.4	1.9	1.0	0.5	1.6	1.3	0.3	0.7	1.4	1.8	0.5	0.3
Neuroticism score	0.1	0.2	1.3	-0.6	0.6	-0.7	1.1	-0.0	0.2	0.6	-0.3	-0.0	0.2	0.2	0.3	-0.2
Weight	2.3	11.3	20.3	-1.0	-3.7	-2.0	-1.7	-3.2	-4.3	-4.1	-2.9	-3.0	-4.4	-4.5	-3.8	-2.8
Impedance of arm (right)	0.6	2.6	8.1	-2.9	-0.2	2.6	1.3	-1.4	1.1	0.7	-1.7	-1.8	0.8	1.6	-0.3	-2.0
Arm fat percentage (right)	1.1	4.2	13.6	-3.7	-1.7	0.3	0.1	-2.6	-0.9	-0.8	-3.1	-2.4	-1.9	-0.7	-1.8	-2.8
Trunk fat-free mass	2.0	11.4	29.2	1.9	-3.5	-3.2	-2.6	-2.0	-5.0	-4.5	-1.2	-1.6	-4.4	-5.4	-3.5	-1.1
Hip circumference	2.1	8.9	15.1	-1.3	-3.4	-2.1	-2.4	-2.9	-3.5	-3.3	-2.7	-2.6	-3.8	-3.9	-3.2	-2.6
Time employed in main current job	0.1	0.1	0.5	0.3	-0.1	0.1	-0.2	-0.0	0.5	0.1	0.1	-0.3	0.7	0.6	-0.0	-0.0
Alcohol intake versus 10 years previously	0.9	1.3	6.1	-0.1	1.3	2.5	0.8	0.8	1.1	1.1	0.5	0.9	1.4	1.2	0.9	0.6
Father’s age at death	0.3	0.4	2.2	-0.7	0.4	1.5	-0.3	0.0	1.0	0.4	-0.2	-0.2	0.6	0.9	0.3	-0.1
Worrier / anxious feelings	0.1	0.2	1.8	0.2	-0.2	-1.3	0.3	-0.3	-0.4	-0.2	-0.2	-0.6	0.3	-0.1	-0.3	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	12.4	-1.2	0.7	1.5	3.5	0.1	1.1	1.4	-0.4	0.1	0.2	1.2	0.7	-0.2
Falls in the last year	0.3	0.3	2.1	-0.7	-0.1	1.5	0.6	-0.5	-0.1	-0.2	-0.7	-0.5	0.1	0.0	-0.4	-0.5
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	1.2	0.2	1.2	1.3	0.7	0.2	0.3	1.0	0.6	0.4	0.4	0.5	0.7
Number of live births	1.6	2.3	6.6	2.6	0.8	0.1	-0.6	1.9	0.9	0.7	2.2	2.1	1.1	0.3	1.2	2.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	6.1	2.1	-0.1	-0.1	-0.1	0.2	-1.8	-1.7	0.8	-0.0	-1.0	-2.5	-0.4	0.7
Pulse rate	3.1	5.3	7.7	0.7	2.6	2.5	2.2	2.4	2.3	2.5	2.1	2.4	2.5	2.1	2.8	2.0
Happiness	0.2	0.3	0.9	0.4	0.3	-0.7	-0.6	0.5	0.3	1.0	0.5	0.7	0.1	0.6	0.4	0.5
Noisy workplace	0.6	0.8	4.4	-0.4	-0.7	1.4	2.1	-0.3	0.1	0.8	-0.4	-0.2	0.5	1.2	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.6	2.3	-0.2	0.2	0.4	-0.2	0.4	1.3	1.3	0.2	0.4	0.9	1.5	0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.2	-0.7	-0.4	0.3	1.5	-0.8	-0.3	-0.0	-0.9	-0.8	0.0	0.6	-0.7	-0.7
Mouth/teeth dental problems: Dentures	0.0	0.1	0.5	0.3	-0.0	-0.7	-0.1	-0.0	-0.2	-0.4	0.1	-0.1	-0.1	-0.2	-0.2	0.2
Asthma	0.1	0.2	1.7	-1.3	-0.0	0.5	0.0	-0.3	0.6	0.0	-0.7	-0.2	0.1	0.3	-0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.8	-0.0	1.2	0.9	1.3	0.9	0.9	1.0	0.6	0.9	0.8	0.8	1.2	0.8
Medication: Cholesterol lowering	0.7	1.0	3.1	-1.3	-1.0	-1.8	-0.7	-1.0	-0.6	-0.0	-1.2	-0.9	-1.1	0.1	-0.8	-1.1
Depression (self-reported)	2.7	3.2	4.9	-2.1	-2.1	-1.4	-0.1	-1.9	-1.3	-1.9	-1.9	-2.1	-2.0	-1.8	-1.6	-2.2
Medication: Lansoprazole	0.3	0.3	0.7	0.8	0.7	0.1	0.6	0.7	0.1	-0.3	0.8	0.3	0.7	-0.2	0.6	0.7
Prospective memory result	0.6	0.7	2.0	-0.5	0.4	1.2	1.0	0.7	1.1	1.4	0.4	0.8	0.4	0.8	1.1	0.4
Lung cancer (father)	3.4	4.0	7.0	1.2	1.7	2.6	1.9	2.0	2.1	2.1	1.8	2.0	2.5	2.1	1.9	1.9
Illnesses of mother	2.5	3.0	11.4	3.4	1.8	0.0	0.4	2.2	-0.3	0.2	2.8	1.8	0.6	-0.6	1.6	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.1	1.1	0.1	1.4	0.1	0.3	-0.7	-1.1	0.7	0.1	-0.3	-1.4	0.1	0.5
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	0.4	0.5	-0.6	0.8	0.9	0.8	1.4	0.8	0.9	1.5	1.4	0.9	0.7
Impedance of arm (left)	0.4	1.8	6.4	-1.8	0.4	2.5	1.8	-0.6	1.3	0.8	-0.7	-1.1	1.6	1.6	0.4	-1.1
Arm fat mass (right)	1.3	5.5	9.1	-2.2	-2.4	-0.9	-0.5	-2.7	-2.4	-2.2	-2.9	-2.4	-3.0	-2.5	-2.5	-2.5
Trunk predicted mass	2.0	11.3	28.6	2.0	-3.5	-3.1	-2.5	-2.0	-5.0	-4.5	-1.2	-1.6	-4.3	-5.3	-3.5	-1.1
Standing height	1.6	16.0	39.6	1.9	-4.3	-2.4	-2.4	-3.0	-5.9	-5.7	-1.8	-3.0	-4.7	-6.3	-4.4	-2.1
Length of working week for main job	0.6	0.7	5.8	-0.6	0.2	2.4	0.3	0.0	0.7	0.6	-0.2	0.1	0.9	1.0	-0.0	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.4	0.5	0.8	0.3	0.4	0.6	-0.0	0.5	0.4	0.8	-0.1	0.3	0.6
Breastfed as a baby	0.4	0.5	2.7	-0.3	-0.2	0.4	0.2	-0.3	-1.0	-0.8	-0.1	-0.6	-1.6	-1.2	0.0	-0.4
Tense / ‘highly strung’	0.3	0.5	2.0	-0.2	1.0	-1.4	1.4	0.3	0.0	0.7	0.2	0.3	-0.5	-0.0	0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.6	-0.4	-0.9	-1.4	-1.5	-1.2	-1.6	-1.1	-1.1	-1.3	-2.2	-1.7	-1.2	-1.0
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	-0.7	0.2	0.1	0.0	-0.2	0.5	0.4	-0.4	-0.3	0.3	1.1	0.1	-0.3
Birth weight of first child	0.3	0.6	3.7	-0.3	-0.9	-1.9	0.1	-0.6	-0.9	-0.4	-0.5	-0.6	-0.6	-0.3	-0.5	-0.7
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.5	0.3	-0.3	0.3	0.2	0.2	0.5	0.1	0.3	-0.5	-0.1	0.4	0.1
Pulse wave reflection index	0.3	0.4	1.7	0.1	-0.4	-1.2	-1.3	-0.4	-0.9	-0.2	-0.2	-0.3	-0.2	-0.1	-0.5	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	-0.7	-0.6	-0.1	-0.6	-0.5	-0.8	-0.4	-0.5	-0.5	-1.2	-0.7	-0.3	-0.6
Loud music exposure frequency	0.5	0.6	1.8	0.5	1.2	1.3	0.8	0.6	-0.2	0.8	0.4	0.7	-0.5	0.2	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.0	-0.6	-0.2	1.4	-0.7	0.4	1.3	1.1	0.1	0.5	0.7	1.4	0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	4.5	-2.1	0.1	-0.9	-0.3	-1.1	-0.9	-0.6	-1.2	-1.1	-1.3	-0.8	-0.3	-1.3
Blood clot in the leg (DVT)	0.4	0.5	1.7	0.5	0.6	0.5	0.3	0.6	0.7	1.3	0.3	0.7	0.7	1.2	0.4	0.6
Medication: Paracetamol	0.7	1.2	2.4	-0.9	-1.1	-0.0	-0.8	-1.3	-1.0	-0.7	-1.5	-1.2	-1.5	-0.9	-1.3	-1.3
Headache pain in last month	1.2	2.1	5.2	-0.0	1.7	1.1	0.8	1.3	1.5	2.3	0.9	1.5	1.4	1.9	1.5	1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.0	2.4	1.4	1.6	0.9	1.7	0.7	-0.0	2.2	1.5	1.4	-0.2	1.3	1.9
Glaucoma (self-reported)	0.2	0.3	2.6	0.0	-0.3	-0.4	1.6	-0.1	0.1	-0.1	-0.1	0.1	0.6	0.4	-0.4	0.0
Gout (self-reported)	1.6	2.2	6.9	0.9	1.4	0.6	-0.2	1.6	1.7	0.9	1.6	1.6	2.6	1.4	1.5	1.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.7	-1.4	-1.6	2.4	2.4	-1.3	-0.2	-1.1	-1.4	-1.3	-0.7	-0.4	-1.2	-1.4
Medication: Amlodipine	1.4	1.9	4.0	-2.0	-1.7	-0.4	-0.8	-1.7	-0.5	-0.6	-2.0	-1.6	-1.2	-0.1	-1.4	-1.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	7.8	-2.8	-1.1	0.6	0.1	-1.1	0.6	-0.0	-1.7	-0.8	-0.7	0.2	-0.7	-1.4
Birth weight	0.2	0.5	2.0	1.4	-0.1	-0.6	-0.2	0.3	-0.6	-1.0	0.6	0.2	-0.6	-1.1	-0.2	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.8	-0.7	0.2	1.7	0.6	0.1	0.4	0.9	-0.2	0.3	-0.9	0.8	0.2	-0.1
High blood pressure (siblings)	0.1	0.1	0.4	-0.0	0.1	-0.4	-0.4	0.2	-0.2	-0.0	0.1	0.1	-0.6	-0.5	0.4	0.2
Forced vital capacity (FVC), Best measure	0.3	1.1	4.5	1.1	-0.3	1.7	-0.2	0.1	-1.3	-1.4	0.5	-0.0	-0.9	-2.1	-0.3	0.4
Body fat percentage	1.2	4.6	11.5	-3.4	-1.8	0.0	0.0	-2.7	-1.5	-1.2	-3.1	-2.6	-2.3	-1.2	-1.9	-2.8
Leg fat percentage (right)	0.9	3.1	8.8	-3.0	-1.4	0.0	-0.1	-2.1	-1.2	-0.7	-2.6	-2.0	-2.1	-0.9	-1.4	-2.3
Arm fat-free mass (right)	1.8	9.0	25.4	2.4	-2.8	-3.1	-2.1	-1.4	-4.6	-4.2	-0.6	-1.1	-3.7	-5.0	-2.9	-0.4
Exposure to tobacco smoke outside home	0.7	1.0	2.6	1.0	1.0	1.6	-1.4	0.9	0.4	1.0	0.9	1.0	0.3	0.7	0.9	1.0
Comparative body size at age 10	0.5	1.3	2.2	-1.2	-1.5	-0.6	-0.4	-1.4	-0.5	-1.4	-1.3	-1.4	-1.1	-0.9	-1.3	-1.4
Number of full brothers	0.9	1.1	2.0	1.2	1.1	-0.0	0.6	1.3	1.1	0.6	1.3	1.1	1.4	0.7	1.1	1.3
Worry too long after embarrassment	0.7	1.2	3.9	-2.0	-0.6	-0.2	1.5	-1.1	-0.5	-0.3	-1.4	-1.1	-1.0	-0.5	-0.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	4.5	5.9	11.7	-1.4	-2.4	-2.3	-1.7	-2.4	-2.7	-2.3	-2.4	-2.4	-3.4	-2.7	-2.4	-2.3
Wheeze or whistling in the chest in last year	0.4	0.8	6.1	-0.2	1.2	2.5	0.2	0.5	0.7	0.6	0.3	0.6	-0.3	0.1	0.7	0.6
Number of children fathered	1.5	1.6	3.2	0.2	1.3	-1.2	-1.0	1.3	1.3	1.6	0.9	1.8	1.5	1.3	1.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.5	1.0	1.6	1.2	0.5	1.6	1.7	1.9	1.4	1.9	1.5	1.7	1.5	1.5
Age at first live birth	0.6	1.0	3.3	-1.6	-0.1	0.6	1.3	-0.0	1.4	1.1	-0.5	0.1	1.3	1.8	0.3	-0.5
Pulse wave peak to peak time	1.1	1.3	3.5	-0.2	-0.8	0.3	-1.0	-1.0	-1.1	-1.6	-0.9	-1.0	-1.9	-1.7	-1.2	-0.8
Health satisfaction	0.2	0.3	1.2	-0.3	0.3	-1.1	0.7	0.3	-0.0	1.1	0.2	0.3	0.1	0.5	0.6	0.1
Shortness of breath walking on level ground	0.6	0.7	5.2	-1.2	-0.2	0.3	2.3	-0.2	0.7	0.6	-0.4	-0.3	0.7	0.9	0.3	-0.5
Qualifications: College or University degree	0.1	0.4	1.2	-0.8	-0.4	-0.6	-0.4	-0.6	-0.5	0.0	-0.7	-0.6	-1.1	-0.2	-0.4	-0.8
Eye problems/disorders: None of the above	0.8	0.9	3.7	1.9	0.0	-0.2	-0.2	0.1	-1.6	-1.3	0.5	-0.0	-0.7	-1.7	-0.4	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.3	0.6	0.3	0.9	0.2	-0.5	-0.0	0.3	0.2	-0.7	-0.3	0.1	0.4
Emphysema/chronic bronchitis	0.5	0.6	4.0	-0.3	-0.5	-2.0	-0.2	-0.5	-0.9	-0.7	-0.4	-0.7	-0.8	-0.5	-0.4	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	1.2	0.1	0.3	0.2	0.8	0.3	-0.1	1.0	0.8	0.9	0.1	0.3	0.8
Neck or shoulder pain in last month	2.2	3.1	8.9	-1.2	1.4	1.6	0.3	1.0	2.6	2.9	0.3	1.2	2.2	3.0	1.6	0.5
Medication: Blood pressure	0.5	0.8	2.2	-1.5	-0.9	-1.2	-0.6	-1.0	-0.4	0.2	-1.3	-0.8	-0.6	0.4	-0.7	-1.1
Angina (self-reported)	6.6	8.7	14.0	-0.7	-3.1	-2.0	-2.0	-3.0	-3.7	-3.6	-2.4	-3.2	-3.7	-3.6	-3.1	-2.7
Migraine (self-reported)	0.3	0.4	1.7	-0.5	0.5	0.8	0.9	0.2	0.5	0.3	0.0	0.2	1.3	0.7	0.4	0.1
Medication: Ibuprofen	0.4	0.5	1.2	-0.2	1.0	1.0	0.7	0.6	0.5	1.1	0.4	0.6	0.4	0.7	1.0	0.5
Medication: Allopurinol	2.0	2.6	4.5	1.3	2.0	0.6	-0.8	2.0	1.4	1.0	1.9	1.9	2.1	1.1	1.8	2.0
Medication: Omeprazole	0.9	1.1	2.7	-1.1	0.9	-0.2	1.6	0.6	1.3	1.5	0.3	0.5	0.8	1.4	1.2	0.1
Medication: Seretide 50 evohaler	0.3	0.4	3.2	0.1	0.2	-1.8	-1.0	0.0	0.2	0.4	-0.1	0.2	0.1	0.0	-0.0	0.0
Mean time to correctly identify matches	0.6	1.1	1.8	-0.9	-0.8	0.5	1.3	-1.3	-0.8	-1.1	-1.3	-1.3	-0.8	-0.7	-1.3	-1.2
Heart disease (mother)	2.9	3.5	5.5	-1.3	-2.0	0.2	-0.7	-2.2	-1.9	-2.0	-2.1	-2.3	-2.0	-1.8	-2.3	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	-0.2	0.5	-0.3	0.7	0.2	-0.2	-0.4	0.2	0.3	0.1	-0.6	0.2	0.2
Whole body fat mass	1.4	6.0	9.8	-2.3	-2.6	-0.9	-0.7	-2.8	-2.6	-2.3	-2.9	-2.5	-3.1	-2.5	-2.6	-2.7
Leg fat mass (right)	1.3	5.1	9.2	-2.0	-2.4	-1.2	-0.7	-2.5	-2.5	-2.0	-2.7	-2.2	-3.0	-2.4	-2.5	-2.4
Arm predicted mass (right)	1.8	9.1	24.9	2.6	-2.8	-3.2	-2.1	-1.3	-4.6	-4.3	-0.5	-1.1	-3.6	-5.0	-2.9	-0.3
Pulse rate, automated reading	2.8	8.9	18.5	0.2	3.5	2.4	1.1	3.0	3.4	4.3	2.4	3.1	3.1	3.8	3.6	2.4
Alcohol intake frequency.	0.4	0.9	2.5	-0.9	0.1	0.7	1.6	0.4	1.4	1.6	-0.1	0.6	0.5	1.5	0.6	0.1
Comparative height size at age 10	0.8	4.7	10.3	0.4	-2.6	-1.0	-1.3	-1.9	-3.1	-3.1	-1.2	-2.0	-2.0	-3.2	-2.4	-1.5
Number of full sisters	2.0	2.5	4.4	2.1	1.7	1.1	1.6	1.8	1.0	0.9	2.0	1.8	1.4	0.7	1.5	2.1
Suffer from ‘nerves’	0.3	0.5	2.3	-1.1	-0.2	0.3	1.5	-0.6	0.0	-0.0	-0.8	-0.4	-1.0	-0.3	-0.4	-0.6
Overall health rating	0.3	0.7	1.9	-1.4	-0.5	0.5	-0.2	-0.9	0.0	0.9	-1.2	-0.6	-1.0	0.6	-0.6	-1.0
Chest pain or discomfort	0.4	0.5	3.0	0.7	0.6	-1.7	-0.9	0.2	-0.6	-0.2	0.4	0.0	-1.0	-0.7	0.2	0.4
Had major operations	1.6	1.9	3.2	-1.3	-1.5	-1.7	-0.9	-1.7	-0.9	-0.9	-1.8	-1.6	-1.2	-0.5	-1.6	-1.6
Age at last live birth	0.4	0.6	1.8	-0.7	0.1	1.4	0.8	0.4	1.2	1.0	0.1	0.6	0.5	1.1	0.6	0.1
Family relationship satisfaction	0.4	0.5	2.1	-0.4	0.0	1.0	0.4	0.2	0.8	1.4	-0.0	0.5	0.1	1.3	0.2	-0.1
Leg pain on walking	0.2	0.2	0.9	-0.1	-0.9	0.4	0.1	-0.5	-0.5	-0.4	-0.6	-0.4	-0.4	-0.6	-0.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.7	1.1	-1.1	-0.8	-1.1	-0.5	-1.3	-1.6	-0.3	-0.4	-0.4	-1.5	-1.4	0.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	-0.1	0.8	0.3	1.3	0.9	1.1	1.4	0.7	1.0	1.2	1.5	0.9	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.5	-0.6	1.0	0.1	-0.6	0.6	1.1	1.1	0.4	0.4	1.0	1.2	1.1	0.2
Medication: Aspirin	0.9	1.1	5.1	-1.1	-0.7	-1.1	-2.3	-1.0	-0.7	-0.5	-1.1	-1.2	-0.6	-0.2	-0.7	-1.1
Supplements: Vitamin C	0.5	0.6	1.5	-0.6	-0.9	-0.5	-0.4	-0.8	-1.0	-0.7	-0.7	-0.8	-1.2	-0.8	-0.6	-0.9
Knee pain experienced in last month	1.3	2.0	10.2	-3.2	-0.4	2.0	-0.2	-1.2	1.0	0.9	-1.9	-0.9	-0.3	1.0	-0.4	-1.6
Hypertension (Self-reported)	0.3	0.9	4.2	-2.0	-0.4	-0.1	-0.9	-1.0	-0.2	0.5	-1.4	-0.8	-0.6	0.7	-0.5	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.3	7.4	12.7	0.9	3.4	1.1	2.5	3.2	3.0	2.6	2.9	3.2	2.7	2.2	3.6	2.8
Illnesses of father: Heart disease	6.5	9.0	14.5	-1.6	-3.8	-0.5	-1.8	-3.5	-3.3	-3.3	-3.1	-3.7	-2.8	-2.7	-3.6	-3.4
Illnesses of siblings: Diabetes	1.0	1.3	3.8	0.5	-0.7	-0.2	0.6	-0.9	-1.5	-1.9	-0.5	-1.3	-1.4	-1.7	-1.1	-0.5
Smoking status: Previous	1.1	1.7	6.4	1.4	-0.8	-0.2	-0.9	-0.5	-1.7	-2.5	0.1	-0.7	-1.1	-2.4	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	7.1	1.4	-1.7	-0.1	-0.0	-1.0	-2.2	-2.7	-0.4	-1.0	-1.6	-2.6	-1.8	-0.4
Whole body fat-free mass	2.1	11.8	28.2	1.4	-3.7	-3.1	-2.4	-2.3	-4.9	-4.7	-1.6	-2.0	-4.4	-5.3	-3.8	-1.5
Leg fat-free mass (right)	2.2	11.6	24.8	0.5	-3.9	-2.6	-2.0	-2.8	-4.6	-4.6	-2.2	-2.5	-4.3	-5.0	-3.9	-2.1
Arm fat percentage (left)	0.9	3.6	9.5	-3.1	-1.5	0.1	0.3	-2.4	-1.2	-1.2	-2.8	-2.3	-1.8	-1.1	-1.7	-2.5
Average weekly red wine intake	0.1	0.2	1.5	0.1	0.0	-1.2	-0.1	-0.0	-0.3	0.1	0.1	-0.1	-0.7	-0.1	0.1	-0.0
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.7	-1.9	-0.4	0.8	1.1	-0.7	0.9	0.9	-1.1	-0.6	0.4	1.3	-0.2	-1.1
Mood swings	0.5	1.0	6.3	1.6	0.1	-2.5	-0.3	0.2	-1.0	-0.6	0.4	0.2	0.1	-1.1	-0.4	0.7
Loneliness, isolation	0.9	1.3	5.0	0.9	-0.6	-1.1	-0.6	-0.4	-1.9	-1.6	-0.2	-0.4	-1.3	-2.2	-0.7	-0.1
Long-standing illness, disability or infirmity	3.4	5.3	9.6	-2.6	-2.7	1.5	0.9	-2.9	-1.4	-1.3	-3.1	-3.0	-2.3	-0.7	-2.5	-3.0
Ever had bowel cancer screening	0.8	0.9	2.4	-0.9	0.8	-0.0	1.6	0.8	1.3	1.4	0.6	0.7	0.3	0.9	1.5	0.4
Diabetes diagnosed by doctor	0.8	1.3	3.1	-1.3	1.3	0.9	0.3	0.7	1.6	1.8	0.3	0.9	0.3	1.8	1.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	0.9	0.6	0.2	-0.1	0.8	0.3	0.4	0.7	0.9	0.7	0.4	0.4	0.9
Friendships satisfaction	0.2	0.2	1.2	0.1	-0.5	-0.6	-1.1	-0.2	-0.3	0.0	-0.2	0.0	-0.9	-0.2	-0.4	-0.1
Qualifications: nursing, teaching	0.1	0.2	1.0	-0.6	-0.1	0.2	-1.0	-0.0	0.5	0.1	-0.1	-0.1	0.6	0.6	0.3	-0.2
Commuting to job workplace: Walk	1.2	1.2	3.0	0.2	-0.8	-1.2	-0.9	-0.8	-1.6	-1.4	-0.5	-1.0	-1.6	-1.7	-0.8	-0.6
Eye problems/disorders: Cataract	2.2	2.6	8.3	-0.6	1.2	-0.1	0.6	1.1	2.4	2.1	0.9	1.1	2.5	2.9	1.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.2	-0.4	0.8	0.2	-0.2	0.3	0.4	1.1	0.2	0.3	0.8	1.0	0.6	0.1
Medication for cholesterol	0.9	1.4	4.3	1.3	-1.3	-0.6	1.0	-0.7	-1.5	-2.1	-0.2	-1.0	-0.4	-1.7	-1.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.6	0.5	0.2	1.3	-0.7	0.3	0.3	0.5	0.3	0.2	0.6	0.4	0.2	0.3
Back pain experienced in last month	0.1	0.1	0.6	-0.1	-0.3	0.4	0.8	-0.1	0.1	0.1	-0.1	-0.1	-0.1	0.0	0.0	-0.1
Mineral and other dietary supplements	0.5	0.7	3.0	-0.1	-0.7	-1.7	-0.9	-0.5	-1.1	-0.9	-0.3	-0.5	-1.0	-0.9	-0.6	-0.5
Breast cancer (self-reported)	1.3	1.6	4.2	0.6	-1.1	0.2	-0.3	-1.0	-1.9	-2.1	-0.6	-1.3	-1.3	-1.9	-1.5	-0.7
Asthma (self-reported)	0.1	0.2	1.5	-1.2	-0.0	0.2	0.0	-0.4	0.5	-0.0	-0.7	-0.3	0.0	0.3	-0.2	-0.3
Osteoporosis (self-reported)	1.6	1.9	2.9	1.3	0.9	1.1	1.1	1.5	1.6	1.5	1.5	1.7	1.5	1.4	1.1	1.5
Osteoarthritis (self-reported)	1.6	2.0	7.6	-2.8	-1.2	1.7	1.4	-1.5	0.3	0.2	-1.9	-1.4	-0.3	0.7	-0.8	-1.7
Medication: Aspirin	1.0	1.3	5.8	-1.3	-0.8	-0.7	-2.4	-1.2	-0.7	-0.6	-1.3	-1.3	-0.5	-0.1	-0.8	-1.3
Medication: Gliclazide	0.3	0.3	1.7	-1.1	0.6	-1.3	0.0	-0.0	0.5	0.3	-0.2	0.1	-0.3	0.3	0.4	-0.2
Illnesses of father: None of the above (group 1)	3.1	3.8	7.2	1.8	2.3	1.1	1.1	2.4	1.7	1.5	2.3	2.7	1.9	1.1	2.1	2.5
Smoking status: Current	0.8	1.3	2.1	1.2	1.1	1.0	1.5	1.1	1.0	1.0	1.1	1.1	1.2	1.0	1.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.8	-0.2	1.5	1.9	2.4	1.4	2.1	1.7	1.1	1.4	1.5	1.7	1.7	1.1
Whole body water mass	2.1	11.8	28.5	1.5	-3.7	-3.2	-2.4	-2.3	-5.0	-4.7	-1.6	-2.0	-4.4	-5.3	-3.8	-1.5
Leg predicted mass (right)	2.0	10.7	23.5	0.6	-3.7	-2.6	-1.9	-2.6	-4.4	-4.5	-2.0	-2.4	-4.1	-4.8	-3.8	-1.9
Arm fat mass (left)	1.3	5.4	8.9	-2.0	-2.3	-0.9	-0.5	-2.6	-2.5	-2.4	-2.7	-2.4	-3.0	-2.7	-2.5	-2.4
Number of self-reported non-cancer illnesses	1.7	3.0	5.9	-2.4	-1.6	1.2	1.3	-2.2	-1.1	-0.9	-2.4	-2.3	-1.2	-0.3	-1.7	-2.2
Average weekly champagne plus white wine intake	1.2	1.6	4.8	-0.4	0.8	2.2	0.9	1.2	1.8	1.2	0.9	1.2	0.9	1.3	1.5	0.9
Miserableness	0.7	1.2	9.5	-0.0	0.5	-0.1	3.1	0.6	1.0	1.2	0.3	0.6	1.2	1.0	0.7	0.5
Guilty feelings	0.1	0.2	0.5	-0.6	-0.4	0.3	0.2	-0.5	-0.3	-0.7	-0.5	-0.5	-0.0	-0.6	-0.3	-0.5
Wears glasses or contact lenses	1.1	1.3	3.5	-1.9	-1.1	-0.9	1.1	-1.3	-0.3	-0.7	-1.5	-1.2	-0.6	-0.4	-1.0	-1.4
Ever taken oral contraceptive pill	1.0	1.1	2.8	-0.1	0.6	1.2	1.1	0.8	1.7	1.4	0.4	1.0	0.9	1.5	0.9	0.6
Hearing aid user	0.1	0.2	0.7	-0.5	-0.7	-0.4	-0.8	-0.3	0.2	-0.1	-0.4	-0.0	0.1	0.2	-0.4	-0.4
Mother’s age at death	0.4	0.5	1.1	-0.5	-0.7	-0.4	0.4	-0.7	-0.9	-1.0	-0.6	-0.9	-0.2	-0.8	-0.5	-0.8
Financial situation satisfaction	0.1	0.1	0.6	0.2	0.3	0.2	0.0	-0.0	-0.3	0.1	0.1	-0.0	-0.8	-0.2	0.1	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.8	-1.1	0.6	0.8	-0.9	-0.4	-0.9	-0.9	-0.8	-0.8	-0.8	-0.8	-1.0
Commuting to job workplace: Public transport	0.8	0.9	1.8	-0.9	-0.6	0.7	-0.0	-1.2	-0.6	-0.7	-1.3	-1.3	-1.3	-0.8	-0.9	-1.1
Eye problems/disorders: Glaucoma	0.2	0.2	1.7	0.2	-0.4	-0.0	1.3	-0.1	0.0	0.1	-0.1	0.0	0.5	0.4	-0.3	-0.1
Medication: Blood pressure	0.4	0.7	4.0	-2.0	-0.1	0.1	-0.7	-0.8	0.4	0.7	-1.2	-0.6	-0.4	0.8	-0.2	-1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.6	-1.6	-0.3	2.4	1.2	-0.6	0.8	0.0	-1.0	-0.5	0.2	0.3	-0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	5.6	-0.7	0.1	1.7	2.4	0.0	1.0	0.5	-0.2	0.0	1.0	0.8	0.2	-0.1
High cholesterol (Self-reported)	0.4	0.7	2.6	-1.6	-0.6	-1.1	-0.9	-0.7	-0.2	0.6	-0.9	-0.6	-1.1	0.3	-0.2	-1.1
Medication: Bendroflumethiazide	1.1	1.6	5.2	-2.3	-1.1	1.0	0.2	-1.5	-0.1	-0.1	-1.9	-1.4	-0.9	0.5	-1.0	-1.8
Medication: Paracetamol	0.3	0.5	1.4	-1.2	-0.2	1.0	0.0	-0.8	-0.0	0.3	-1.1	-0.6	-0.8	0.1	-0.5	-0.9
Medication: Lisinopril	0.4	0.5	1.5	-0.4	-0.1	1.2	-1.2	-0.5	-0.7	0.1	-0.6	-0.5	-1.2	-0.1	-0.3	-0.5
Medication: Atorvastatin	1.5	1.8	9.1	0.0	-0.7	-3.0	-2.3	-0.6	-1.2	-0.6	-0.5	-0.5	-2.0	-1.1	-0.7	-0.6
Illnesses of father: High blood pressure	0.2	0.3	1.7	0.1	-0.3	-1.3	-1.1	-0.2	-0.3	-0.6	-0.1	-0.4	0.1	-0.2	-0.2	-0.1
Alcohol drinker status: Never	2.3	2.7	8.4	1.0	-1.1	-2.9	-1.3	-0.7	-2.2	-1.9	-0.3	-0.8	-2.4	-2.6	-1.1	-0.5
Ever smoked	0.5	0.8	3.5	1.2	-0.6	0.5	0.3	-0.5	-1.0	-1.9	-0.1	-0.8	-0.6	-1.3	-0.9	0.1
Basal metabolic rate	2.2	12.3	28.5	0.9	-3.8	-2.9	-2.2	-2.6	-5.0	-4.7	-2.0	-2.3	-4.6	-5.3	-3.9	-1.9
Leg fat percentage (left)	0.7	2.6	7.1	-2.7	-1.3	0.1	-0.0	-1.9	-1.2	-0.7	-2.3	-1.8	-2.0	-0.9	-1.3	-2.0
Arm fat-free mass (left)	2.0	9.9	24.8	1.5	-3.2	-2.9	-2.5	-1.9	-4.7	-4.2	-1.3	-1.6	-4.2	-5.0	-3.3	-1.1
Number of operations (self-reported)	0.5	0.8	1.3	-0.2	-1.1	-0.4	-1.1	-1.0	-1.0	-1.1	-0.9	-1.1	-0.2	-0.7	-1.1	-0.8
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.6	-0.8	1.1	1.3	-1.0	-0.6	-0.3	-1.0	-1.0	-0.4	-0.1	-1.0	-0.9
Irritability	0.3	0.6	1.0	0.3	1.0	-0.8	0.2	0.8	0.9	0.9	0.6	0.8	1.0	0.7	0.9	0.7
Risk taking	2.8	4.2	6.5	1.3	2.2	0.4	-1.0	2.4	2.2	2.0	2.2	2.5	2.6	1.8	2.4	2.3
Ever had prostate specific antigen (PSA) test	4.4	5.0	9.7	-1.0	-1.7	-2.5	-0.5	-2.2	-2.8	-2.9	-1.9	-2.3	-2.7	-3.1	-2.1	-1.9
Fractured/broken bones in last 5 years	0.8	1.1	2.4	1.0	0.7	-1.5	-0.9	1.0	1.0	1.0	0.9	1.0	1.2	1.1	0.7	1.1
Age started oral contraceptive pill	3.0	3.8	6.6	-2.2	-2.2	-0.3	-0.6	-2.4	-1.3	-1.6	-2.3	-2.6	-2.2	-1.3	-2.0	-2.5
Diastolic blood pressure, automated reading	0.3	0.9	2.7	-1.5	0.5	-0.1	-0.9	0.2	0.9	1.7	-0.4	0.4	1.0	1.6	0.7	-0.2
Ever depressed for a whole week	2.5	3.1	5.3	1.9	2.3	-0.1	1.4	2.2	1.0	1.6	2.2	2.1	1.0	0.8	2.1	2.3
Unable to work because of sickness or disability	0.1	0.1	1.0	-0.1	-0.0	1.0	0.5	0.1	0.3	0.6	-0.0	0.2	-0.2	0.4	0.1	0.1
Commuting to job workplace: Cycle	1.5	1.9	3.3	-1.8	-1.6	-0.2	-0.5	-1.6	-0.6	-1.2	-1.7	-1.6	-1.6	-0.9	-1.3	-1.8
Myopia	0.6	0.9	3.0	-1.7	-0.8	-0.5	1.7	-0.9	0.4	-0.0	-1.1	-0.9	-0.1	0.6	-0.6	-1.1
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.8	1.9	1.5	0.9	1.1	2.1	1.5	1.1	2.2	2.1	1.5	0.7	1.8	2.1
Cholesterol lowering medication	0.8	1.2	5.8	-2.4	-0.9	0.0	-0.5	-1.2	0.2	0.5	-1.5	-0.9	-1.1	0.5	-0.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.9	-0.9	0.1	-0.0	1.7	-0.3	0.2	0.2	-0.3	-0.4	-0.0	0.3	0.2	-0.5
Pain experienced in last month	0.8	1.4	4.8	1.7	-0.6	-2.2	-1.4	-0.0	-1.2	-1.7	0.6	-0.2	-0.7	-1.4	-0.7	0.4
Supplements: Calcium	1.8	1.9	3.5	0.8	1.0	1.3	0.6	1.5	1.6	1.9	1.2	1.6	1.7	1.8	1.2	1.4
Basal cell carcinoma (self-reported)	1.4	1.6	5.4	-0.7	-1.1	-2.3	-0.9	-1.1	-1.5	-0.8	-1.0	-1.2	-1.6	-1.2	-1.0	-1.1
Heart attack/myocardial infarction (self-reported)	3.4	4.4	9.5	0.1	-2.0	-2.2	-1.9	-1.7	-2.8	-2.7	-1.2	-1.8	-2.7	-3.1	-2.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	0.3	0.3	0.4	-0.3	0.2	0.2	0.8	0.0	0.3	0.1	0.6	0.1	0.3
Heart disease (siblings)	2.4	2.9	6.2	-0.6	-1.4	-1.4	-0.4	-1.7	-2.2	-2.3	-1.6	-1.7	-2.0	-2.5	-1.9	-1.4
Alcohol drinker status: Previous	4.3	4.9	7.7	1.0	2.3	1.5	0.9	2.6	2.8	2.5	2.2	2.7	2.0	2.4	2.6	2.4
Pack years of smoking	0.2	0.3	1.6	0.4	-0.7	-1.3	-0.1	-0.2	-0.2	0.1	-0.2	-0.1	-0.8	-0.2	-0.5	-0.2
Impedance of whole body	0.4	2.2	6.4	-0.6	1.5	2.5	1.9	0.6	1.6	1.7	0.5	0.1	1.9	2.0	1.4	0.1
Leg fat mass (left)	1.1	4.5	7.8	-1.8	-2.2	-1.1	-0.7	-2.3	-2.4	-1.9	-2.5	-2.1	-2.8	-2.3	-2.3	-2.2
Arm predicted mass (left)	1.8	9.2	22.7	1.5	-3.1	-3.1	-2.5	-1.8	-4.4	-4.0	-1.2	-1.4	-4.0	-4.8	-3.1	-1.0