TWAS hub - USP39

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1800	0.0800	6.5e-03	0.095	NA	0.071	NA	0.067	2.2e-06	NA	4.0e-05	NA	6.9e-05
2	GTEx	Muscle Skeletal	0.1833	0.0483	9.6e-06	0.101	NA	0.056	NA	0.096	4.2e-10	NA	3.2e-06	NA	1.1e-09
3	GTEx	Ovary	0.3960	0.1060	7.2e-04	0.020	NA	0.025	NA	0.046	1.0e-01	NA	8.0e-02	NA	2.8e-02
4	GTEx	Testis	0.2580	0.0810	2.1e-03	-0.005	NA	-0.006	NA	-0.006	6.3e-01	NA	8.9e-01	NA	9.7e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.3396	0.0403	0.0e+00	0.307	0.252	0.327	0.301	0.326	3.5e-40	4.3e-32	4.0e-43	3.6e-39	5.7e-43
6	TCGA	Bladder Urothelial Carcinoma	0.0420	0.0240	4.4e-03	0.001	0.015	-0.002	NA	-0.002	2.7e-01	1.8e-02	5.2e-01	NA	5.2e-01
7	TCGA	Breast Invasive Carcinoma	0.0168	0.0096	3.8e-03	0.001	0.011	0.003	NA	0.004	1.5e-01	1.7e-03	6.9e-02	NA	5.2e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1187	0.0407	1.4e-07	0.079	0.063	0.062	NA	0.083	2.9e-09	1.3e-07	1.5e-07	NA	1.4e-09
9	TCGA	Brain Lower Grade Glioma	0.0732	0.0300	2.5e-05	0.053	0.028	0.042	NA	0.046	1.2e-06	3.5e-04	1.4e-05	NA	5.2e-06
10	TCGA	Liver Hepatocellular Carcinoma	0.1030	0.0500	2.5e-03	0.072	0.038	0.036	NA	0.026	2.9e-04	7.1e-03	8.4e-03	NA	2.2e-02
11	TCGA	Lung Adenocarcinoma	0.0371	0.0174	3.4e-04	0.023	0.029	0.021	NA	0.020	9.6e-04	2.0e-04	1.4e-03	NA	1.7e-03
12	TCGA	Prostate Adenocarcinoma	0.0863	0.0298	1.4e-08	0.118	0.084	0.098	NA	0.110	2.6e-12	3.9e-09	2.2e-10	NA	1.5e-11
13	TCGA	Thyroid Carcinoma	0.1460	0.0420	1.9e-08	0.073	0.096	0.105	NA	0.106	1.3e-07	1.3e-09	2.1e-10	NA	1.7e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Prostate Cancer	14.5	20.4	47.1	0.4	2.9	3.3	3.4	4.0	6.2	5.9	3.2	4.3	6.3	6.9	4.3	3.2
Angina	7.1	9.4	14.8	-0.8	-3.2	-1.8	-2.0	-3.1	-3.7	-3.8	-2.5	-3.5	-3.9	-3.8	-3.2	-2.8
Angina (self-reported)	6.6	8.7	14.0	-0.7	-3.1	-2.0	-2.0	-3.0	-3.7	-3.6	-2.4	-3.2	-3.7	-3.6	-3.1	-2.7
Illnesses of father: Heart disease	6.5	9.0	14.5	-1.6	-3.8	-0.5	-1.8	-3.5	-3.3	-3.3	-3.1	-3.7	-2.8	-2.7	-3.6	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.3	7.4	12.7	0.9	3.4	1.1	2.5	3.2	3.0	2.6	2.9	3.2	2.7	2.2	3.6	2.8
Coronary Artery Disease (CAD)	5.2	6.2	11.7	-0.4	-3.1	-0.8	-2.7	-2.4	-3.0	-3.4	-2.0	-2.8	-1.7	-3.1	-2.7	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.8	15.6	3.3	3.7	1.4	2.6	3.8	2.7	3.5	3.7	3.9	2.9	2.8	3.5	4.0
Seen a psychiatrist for nerves, anxiety, tension or depression	4.5	5.9	11.7	-1.4	-2.4	-2.3	-1.7	-2.4	-2.7	-2.3	-2.4	-2.4	-3.4	-2.7	-2.4	-2.3
Ever had prostate specific antigen (PSA) test	4.4	5.0	9.7	-1.0	-1.7	-2.5	-0.5	-2.2	-2.8	-2.9	-1.9	-2.3	-2.7	-3.1	-2.1	-1.9
Alcohol drinker status: Previous	4.3	4.9	7.7	1.0	2.3	1.5	0.9	2.6	2.8	2.5	2.2	2.7	2.0	2.4	2.6	2.4
Heel bone mineral density (BMD) T-score, automated (left)	4.2	9.6	12.4	2.3	3.3	2.6	2.6	3.4	3.3	3.2	3.1	3.5	2.9	2.9	3.3	3.4
Lung cancer (father)	3.4	4.0	7.0	1.2	1.7	2.6	1.9	2.0	2.1	2.1	1.8	2.0	2.5	2.1	1.9	1.9
Long-standing illness, disability or infirmity	3.4	5.3	9.6	-2.6	-2.7	1.5	0.9	-2.9	-1.4	-1.3	-3.1	-3.0	-2.3	-0.7	-2.5	-3.0
Heart attack/myocardial infarction (self-reported)	3.4	4.4	9.5	0.1	-2.0	-2.2	-1.9	-1.7	-2.8	-2.7	-1.2	-1.8	-2.7	-3.1	-2.0	-1.4
High blood pressure (mother)	3.2	4.5	13.8	-3.7	-2.8	-0.1	0.7	-2.5	0.7	0.0	-3.1	-2.2	-0.6	1.3	-2.0	-2.8
Pulse rate	3.1	5.3	7.7	0.7	2.6	2.5	2.2	2.4	2.3	2.5	2.1	2.4	2.5	2.1	2.8	2.0
Illnesses of father: None of the above (group 1)	3.1	3.8	7.2	1.8	2.3	1.1	1.1	2.4	1.7	1.5	2.3	2.7	1.9	1.1	2.1	2.5
Age started oral contraceptive pill	3.0	3.8	6.6	-2.2	-2.2	-0.3	-0.6	-2.4	-1.3	-1.6	-2.3	-2.6	-2.2	-1.3	-2.0	-2.5
Medication for hormone replacement therapy	2.9	3.2	5.9	1.3	1.9	0.9	-0.2	2.2	1.7	2.2	2.0	2.4	1.3	1.4	2.1	2.1
Heart disease (mother)	2.9	3.5	5.5	-1.3	-2.0	0.2	-0.7	-2.2	-1.9	-2.0	-2.1	-2.3	-2.0	-1.8	-2.3	-2.0
Heart attack	2.8	3.5	8.0	0.3	-1.8	-2.2	-1.7	-1.4	-2.6	-2.3	-0.9	-1.5	-2.4	-2.8	-1.7	-1.1
Pulse rate, automated reading	2.8	8.9	18.5	0.2	3.5	2.4	1.1	3.0	3.4	4.3	2.4	3.1	3.1	3.8	3.6	2.4
Risk taking	2.8	4.2	6.5	1.3	2.2	0.4	-1.0	2.4	2.2	2.0	2.2	2.5	2.6	1.8	2.4	2.3
Average weekly spirits intake	2.7	3.4	6.9	-2.6	-1.7	-1.4	-0.9	-2.2	-1.2	-1.5	-2.2	-2.2	-1.6	-1.0	-1.7	-2.5
Depression (self-reported)	2.7	3.2	4.9	-2.1	-2.1	-1.4	-0.1	-1.9	-1.3	-1.9	-1.9	-2.1	-2.0	-1.8	-1.6	-2.2
Illnesses of mother	2.5	3.0	11.4	3.4	1.8	0.0	0.4	2.2	-0.3	0.2	2.8	1.8	0.6	-0.6	1.6	2.4
Ever depressed for a whole week	2.5	3.1	5.3	1.9	2.3	-0.1	1.4	2.2	1.0	1.6	2.2	2.1	1.0	0.8	2.1	2.3
Heart disease (siblings)	2.4	2.9	6.2	-0.6	-1.4	-1.4	-0.4	-1.7	-2.2	-2.3	-1.6	-1.7	-2.0	-2.5	-1.9	-1.4
Schizophrenia vs Biploar Disorder	2.3	3.0	6.8	2.2	2.6	1.0	0.4	2.1	0.6	1.1	2.2	1.7	1.8	0.6	2.0	2.3
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	4.2	-1.5	-1.9	0.9	0.2	-2.0	-1.4	-1.6	-2.1	-2.0	-1.7	-1.1	-2.0	-2.0
Weight	2.3	11.3	20.3	-1.0	-3.7	-2.0	-1.7	-3.2	-4.3	-4.1	-2.9	-3.0	-4.4	-4.5	-3.8	-2.8
Alcohol drinker status: Never	2.3	2.7	8.4	1.0	-1.1	-2.9	-1.3	-0.7	-2.2	-1.9	-0.3	-0.8	-2.4	-2.6	-1.1	-0.5
Type 2 Diabetes (T2D) (2018)	2.2	4.2	7.9	-0.3	2.3	2.8	1.8	1.7	2.6	2.5	1.2	1.8	1.5	2.8	2.2	1.3
Neck or shoulder pain in last month	2.2	3.1	8.9	-1.2	1.4	1.6	0.3	1.0	2.6	2.9	0.3	1.2	2.2	3.0	1.6	0.5
Leg fat-free mass (right)	2.2	11.6	24.8	0.5	-3.9	-2.6	-2.0	-2.8	-4.6	-4.6	-2.2	-2.5	-4.3	-5.0	-3.9	-2.1
Eye problems/disorders: Cataract	2.2	2.6	8.3	-0.6	1.2	-0.1	0.6	1.1	2.4	2.1	0.9	1.1	2.5	2.9	1.4	0.8
Basal metabolic rate	2.2	12.3	28.5	0.9	-3.8	-2.9	-2.2	-2.6	-5.0	-4.7	-2.0	-2.3	-4.6	-5.3	-3.9	-1.9
Blood White Count	2.1	15.3	26.8	1.4	5.2	3.8	1.6	4.0	4.2	4.8	3.2	4.3	3.7	4.4	4.4	3.9
Leg fat-free mass (left)	2.1	10.9	22.8	0.2	-3.8	-2.6	-1.8	-2.8	-4.4	-4.4	-2.3	-2.5	-4.2	-4.8	-3.8	-2.2
Leg predicted mass (left)	2.1	11.3	23.0	0.2	-3.9	-2.6	-1.9	-2.9	-4.4	-4.5	-2.4	-2.6	-4.2	-4.8	-3.9	-2.3
Hip circumference	2.1	8.9	15.1	-1.3	-3.4	-2.1	-2.4	-2.9	-3.5	-3.3	-2.7	-2.6	-3.8	-3.9	-3.2	-2.6
Whole body fat-free mass	2.1	11.8	28.2	1.4	-3.7	-3.1	-2.4	-2.3	-4.9	-4.7	-1.6	-2.0	-4.4	-5.3	-3.8	-1.5
Whole body water mass	2.1	11.8	28.5	1.5	-3.7	-3.2	-2.4	-2.3	-5.0	-4.7	-1.6	-2.0	-4.4	-5.3	-3.8	-1.5
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	4.5	0.6	2.1	0.8	0.7	1.6	1.3	1.5	1.5	1.6	1.6	1.3	1.8	1.7
Trunk fat-free mass	2.0	11.4	29.2	1.9	-3.5	-3.2	-2.6	-2.0	-5.0	-4.5	-1.2	-1.6	-4.4	-5.4	-3.5	-1.1
Trunk predicted mass	2.0	11.3	28.6	2.0	-3.5	-3.1	-2.5	-2.0	-5.0	-4.5	-1.2	-1.6	-4.3	-5.3	-3.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.5	1.0	1.6	1.2	0.5	1.6	1.7	1.9	1.4	1.9	1.5	1.7	1.5	1.5
Medication: Allopurinol	2.0	2.6	4.5	1.3	2.0	0.6	-0.8	2.0	1.4	1.0	1.9	1.9	2.1	1.1	1.8	2.0
Number of full sisters	2.0	2.5	4.4	2.1	1.7	1.1	1.6	1.8	1.0	0.9	2.0	1.8	1.4	0.7	1.5	2.1
Leg predicted mass (right)	2.0	10.7	23.5	0.6	-3.7	-2.6	-1.9	-2.6	-4.4	-4.5	-2.0	-2.4	-4.1	-4.8	-3.8	-1.9
Arm fat-free mass (left)	2.0	9.9	24.8	1.5	-3.2	-2.9	-2.5	-1.9	-4.7	-4.2	-1.3	-1.6	-4.2	-5.0	-3.3	-1.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	10.6	-1.6	-1.3	3.2	0.6	-1.6	-0.7	-0.9	-1.8	-1.6	-1.2	-0.7	-1.4	-1.6
Diabetes (mother)	1.9	2.5	9.6	-1.3	1.2	3.1	1.9	0.5	2.0	2.0	0.2	0.7	1.4	2.1	1.1	0.1
Medication: Atenolol	1.9	2.3	3.8	-0.5	-1.8	-1.9	0.9	-1.6	-1.8	-1.1	-1.5	-1.6	-1.9	-1.3	-1.7	-1.5
Major Depression (MDD)	1.8	2.2	3.5	-1.2	-1.5	-0.4	1.4	-1.7	-1.5	-1.1	-1.6	-1.6	-1.9	-1.3	-1.6	-1.8
Rheumatoid Arthritis	1.8	2.5	9.4	3.1	1.0	0.8	1.6	1.8	0.9	0.3	2.2	1.5	1.5	0.3	1.2	2.0
Height	1.8	35.4	69.9	0.5	-6.9	-3.6	-3.4	-5.2	-8.0	-8.1	-3.9	-5.3	-7.3	-8.4	-6.7	-4.4
Trunk fat mass	1.8	7.9	11.5	-2.6	-2.9	-1.1	-0.8	-3.2	-3.1	-2.7	-3.3	-3.1	-3.4	-2.8	-3.0	-3.1
Arm fat-free mass (right)	1.8	9.0	25.4	2.4	-2.8	-3.1	-2.1	-1.4	-4.6	-4.2	-0.6	-1.1	-3.7	-5.0	-2.9	-0.4
Arm predicted mass (right)	1.8	9.1	24.9	2.6	-2.8	-3.2	-2.1	-1.3	-4.6	-4.3	-0.5	-1.1	-3.6	-5.0	-2.9	-0.3
Supplements: Calcium	1.8	1.9	3.5	0.8	1.0	1.3	0.6	1.5	1.6	1.9	1.2	1.6	1.7	1.8	1.2	1.4
Arm predicted mass (left)	1.8	9.2	22.7	1.5	-3.1	-3.1	-2.5	-1.8	-4.4	-4.0	-1.2	-1.4	-4.0	-4.8	-3.1	-1.0
LDL Cholesterol	1.7	2.8	5.4	0.7	2.2	-0.7	0.8	1.9	1.5	2.3	1.8	2.1	0.9	1.5	2.2	1.7
Number of self-reported non-cancer illnesses	1.7	3.0	5.9	-2.4	-1.6	1.2	1.3	-2.2	-1.1	-0.9	-2.4	-2.3	-1.2	-0.3	-1.7	-2.2
Stomach or abdominal pain in last month	1.6	2.0	3.9	0.6	1.3	-0.4	1.1	1.5	2.0	2.0	1.4	1.5	1.4	1.7	1.6	1.2
Number of live births	1.6	2.3	6.6	2.6	0.8	0.1	-0.6	1.9	0.9	0.7	2.2	2.1	1.1	0.3	1.2	2.2
Standing height	1.6	16.0	39.6	1.9	-4.3	-2.4	-2.4	-3.0	-5.9	-5.7	-1.8	-3.0	-4.7	-6.3	-4.4	-2.1
Gout (self-reported)	1.6	2.2	6.9	0.9	1.4	0.6	-0.2	1.6	1.7	0.9	1.6	1.6	2.6	1.4	1.5	1.6
Had major operations	1.6	1.9	3.2	-1.3	-1.5	-1.7	-0.9	-1.7	-0.9	-0.9	-1.8	-1.6	-1.2	-0.5	-1.6	-1.6
Osteoporosis (self-reported)	1.6	1.9	2.9	1.3	0.9	1.1	1.1	1.5	1.6	1.5	1.5	1.7	1.5	1.4	1.1	1.5
Osteoarthritis (self-reported)	1.6	2.0	7.6	-2.8	-1.2	1.7	1.4	-1.5	0.3	0.2	-1.9	-1.4	-0.3	0.7	-0.8	-1.7
Neuroticism (2016)	1.5	2.2	6.1	1.1	-1.0	-0.7	-0.6	-1.2	-2.4	-2.1	-0.7	-1.4	-1.6	-2.5	-1.6	-0.8
Medication: Levothyroxine sodium	1.5	2.5	4.7	-2.0	-1.9	1.8	2.2	-1.7	-0.2	-0.9	-1.9	-1.6	-0.9	-0.1	-1.5	-1.8
Number of children fathered	1.5	1.6	3.2	0.2	1.3	-1.2	-1.0	1.3	1.3	1.6	0.9	1.8	1.5	1.3	1.2	1.3
Medication: Atorvastatin	1.5	1.8	9.1	0.0	-0.7	-3.0	-2.3	-0.6	-1.2	-0.6	-0.5	-0.5	-2.0	-1.1	-0.7	-0.6
Commuting to job workplace: Cycle	1.5	1.9	3.3	-1.8	-1.6	-0.2	-0.5	-1.6	-0.6	-1.2	-1.7	-1.6	-1.6	-0.9	-1.3	-1.8
Heel T-Score	1.4	11.0	16.6	1.0	4.1	2.0	3.1	3.6	4.0	4.1	3.0	3.7	2.5	3.3	4.0	3.3
Taking other prescription medications	1.4	2.1	5.5	-2.3	-1.5	0.1	1.8	-1.8	-0.0	-0.5	-2.1	-1.8	-0.2	0.2	-1.2	-2.0
Medication: Amlodipine	1.4	1.9	4.0	-2.0	-1.7	-0.4	-0.8	-1.7	-0.5	-0.6	-2.0	-1.6	-1.2	-0.1	-1.4	-1.9
Whole body fat mass	1.4	6.0	9.8	-2.3	-2.6	-0.9	-0.7	-2.8	-2.6	-2.3	-2.9	-2.5	-3.1	-2.5	-2.6	-2.7
Basal cell carcinoma (self-reported)	1.4	1.6	5.4	-0.7	-1.1	-2.3	-0.9	-1.1	-1.5	-0.8	-1.0	-1.2	-1.6	-1.2	-1.0	-1.1
Blood Eosinophil Count	1.3	10.2	21.1	1.9	3.9	2.6	3.5	3.4	2.5	4.6	2.8	3.8	1.3	3.0	3.5	3.2
Trunk fat percentage	1.3	5.2	10.2	-3.2	-2.0	-0.1	0.1	-2.8	-1.9	-1.6	-3.1	-2.8	-2.4	-1.6	-2.2	-3.0
Arm fat mass (right)	1.3	5.5	9.1	-2.2	-2.4	-0.9	-0.5	-2.7	-2.4	-2.2	-2.9	-2.4	-3.0	-2.5	-2.5	-2.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.0	2.4	1.4	1.6	0.9	1.7	0.7	-0.0	2.2	1.5	1.4	-0.2	1.3	1.9
Leg fat mass (right)	1.3	5.1	9.2	-2.0	-2.4	-1.2	-0.7	-2.5	-2.5	-2.0	-2.7	-2.2	-3.0	-2.4	-2.5	-2.4
Knee pain experienced in last month	1.3	2.0	10.2	-3.2	-0.4	2.0	-0.2	-1.2	1.0	0.9	-1.9	-0.9	-0.3	1.0	-0.4	-1.6
Breast cancer (self-reported)	1.3	1.6	4.2	0.6	-1.1	0.2	-0.3	-1.0	-1.9	-2.1	-0.6	-1.3	-1.3	-1.9	-1.5	-0.7
Arm fat mass (left)	1.3	5.4	8.9	-2.0	-2.3	-0.9	-0.5	-2.6	-2.5	-2.4	-2.7	-2.4	-3.0	-2.7	-2.5	-2.4
Maternal smoking around birth	1.2	1.7	3.7	0.1	-1.5	0.9	0.6	-1.2	-1.4	-1.6	-1.0	-1.2	-1.9	-1.8	-1.5	-0.9
Waist circumference	1.2	4.6	9.1	-1.9	-2.3	-0.9	-1.0	-2.4	-2.3	-1.8	-2.5	-2.2	-3.0	-2.0	-2.2	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.6	-0.4	-0.9	-1.4	-1.5	-1.2	-1.6	-1.1	-1.1	-1.3	-2.2	-1.7	-1.2	-1.0
Headache pain in last month	1.2	2.1	5.2	-0.0	1.7	1.1	0.8	1.3	1.5	2.3	0.9	1.5	1.4	1.9	1.5	1.1
Body fat percentage	1.2	4.6	11.5	-3.4	-1.8	0.0	0.0	-2.7	-1.5	-1.2	-3.1	-2.6	-2.3	-1.2	-1.9	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	7.1	1.4	-1.7	-0.1	-0.0	-1.0	-2.2	-2.7	-0.4	-1.0	-1.6	-2.6	-1.8	-0.4
Commuting to job workplace: Walk	1.2	1.2	3.0	0.2	-0.8	-1.2	-0.9	-0.8	-1.6	-1.4	-0.5	-1.0	-1.6	-1.7	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.8	-0.2	1.5	1.9	2.4	1.4	2.1	1.7	1.1	1.4	1.5	1.7	1.7	1.1
Average weekly champagne plus white wine intake	1.2	1.6	4.8	-0.4	0.8	2.2	0.9	1.2	1.8	1.2	0.9	1.2	0.9	1.3	1.5	0.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	7.0	-2.6	-0.2	-0.4	-1.7	-0.8	-0.1	0.8	-1.1	-0.6	-0.8	0.6	-0.0	-1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	6.1	-2.5	-0.8	0.5	-0.7	-1.2	-0.3	1.0	-1.6	-1.1	-1.2	0.4	-0.5	-1.7
Arm fat percentage (right)	1.1	4.2	13.6	-3.7	-1.7	0.3	0.1	-2.6	-0.9	-0.8	-3.1	-2.4	-1.9	-0.7	-1.8	-2.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.7	-1.4	-1.6	2.4	2.4	-1.3	-0.2	-1.1	-1.4	-1.3	-0.7	-0.4	-1.2	-1.4
Pulse wave peak to peak time	1.1	1.3	3.5	-0.2	-0.8	0.3	-1.0	-1.0	-1.1	-1.6	-0.9	-1.0	-1.9	-1.7	-1.2	-0.8
Smoking status: Previous	1.1	1.7	6.4	1.4	-0.8	-0.2	-0.9	-0.5	-1.7	-2.5	0.1	-0.7	-1.1	-2.4	-1.1	0.1
Wears glasses or contact lenses	1.1	1.3	3.5	-1.9	-1.1	-0.9	1.1	-1.3	-0.3	-0.7	-1.5	-1.2	-0.6	-0.4	-1.0	-1.4
Medication: Bendroflumethiazide	1.1	1.6	5.2	-2.3	-1.1	1.0	0.2	-1.5	-0.1	-0.1	-1.9	-1.4	-0.9	0.5	-1.0	-1.8
Leg fat mass (left)	1.1	4.5	7.8	-1.8	-2.2	-1.1	-0.7	-2.3	-2.4	-1.9	-2.5	-2.1	-2.8	-2.3	-2.3	-2.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	12.4	-1.2	0.7	1.5	3.5	0.1	1.1	1.4	-0.4	0.1	0.2	1.2	0.7	-0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	7.8	-2.8	-1.1	0.6	0.1	-1.1	0.6	-0.0	-1.7	-0.8	-0.7	0.2	-0.7	-1.4
Illnesses of siblings: Diabetes	1.0	1.3	3.8	0.5	-0.7	-0.2	0.6	-0.9	-1.5	-1.9	-0.5	-1.3	-1.4	-1.7	-1.1	-0.5
Medication: Aspirin	1.0	1.3	5.8	-1.3	-0.8	-0.7	-2.4	-1.2	-0.7	-0.6	-1.3	-1.3	-0.5	-0.1	-0.8	-1.3
Ever taken oral contraceptive pill	1.0	1.1	2.8	-0.1	0.6	1.2	1.1	0.8	1.7	1.4	0.4	1.0	0.9	1.5	0.9	0.6
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.8	1.9	1.5	0.9	1.1	2.1	1.5	1.1	2.2	2.1	1.5	0.7	1.8	2.1
Blood Platelet Count	0.9	10.1	41.0	2.4	2.9	-6.4	-5.0	0.9	-3.7	-1.1	1.4	0.4	-3.6	-4.1	1.1	1.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	-0.5	-1.3	0.1	0.0	-1.2	-1.2	-0.6	-1.0	-1.2	-1.2	-0.7	-1.2	-1.2
Severe depression (siblings)	0.9	1.0	2.5	1.3	1.6	-0.5	0.1	1.2	0.2	0.7	1.3	1.4	0.0	-0.0	1.0	1.4
Alcohol intake versus 10 years previously	0.9	1.3	6.1	-0.1	1.3	2.5	0.8	0.8	1.1	1.1	0.5	0.9	1.4	1.2	0.9	0.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	4.5	-2.1	0.1	-0.9	-0.3	-1.1	-0.9	-0.6	-1.2	-1.1	-1.3	-0.8	-0.3	-1.3
Leg fat percentage (right)	0.9	3.1	8.8	-3.0	-1.4	0.0	-0.1	-2.1	-1.2	-0.7	-2.6	-2.0	-2.1	-0.9	-1.4	-2.3
Number of full brothers	0.9	1.1	2.0	1.2	1.1	-0.0	0.6	1.3	1.1	0.6	1.3	1.1	1.4	0.7	1.1	1.3
Medication: Omeprazole	0.9	1.1	2.7	-1.1	0.9	-0.2	1.6	0.6	1.3	1.5	0.3	0.5	0.8	1.4	1.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.7	1.1	-1.1	-0.8	-1.1	-0.5	-1.3	-1.6	-0.3	-0.4	-0.4	-1.5	-1.4	0.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.2	-0.1	0.8	0.3	1.3	0.9	1.1	1.4	0.7	1.0	1.2	1.5	0.9	0.7
Medication: Aspirin	0.9	1.1	5.1	-1.1	-0.7	-1.1	-2.3	-1.0	-0.7	-0.5	-1.1	-1.2	-0.6	-0.2	-0.7	-1.1
Arm fat percentage (left)	0.9	3.6	9.5	-3.1	-1.5	0.1	0.3	-2.4	-1.2	-1.2	-2.8	-2.3	-1.8	-1.1	-1.7	-2.5
Loneliness, isolation	0.9	1.3	5.0	0.9	-0.6	-1.1	-0.6	-0.4	-1.9	-1.6	-0.2	-0.4	-1.3	-2.2	-0.7	-0.1
Medication for cholesterol	0.9	1.4	4.3	1.3	-1.3	-0.6	1.0	-0.7	-1.5	-2.1	-0.2	-1.0	-0.4	-1.7	-1.3	-0.3
Bipolar Disorder (2011)	0.8	0.8	2.0	-1.4	-1.0	-0.1	0.5	-0.9	0.5	0.6	-1.2	-0.7	0.0	1.3	-0.8	-1.1
Lupus	0.8	1.2	6.8	-0.1	0.9	0.5	2.6	0.8	1.2	1.1	0.5	1.1	1.1	1.1	0.7	0.7
Allergy or Eczema	0.8	2.2	7.0	-2.6	-0.9	2.2	1.0	-1.6	-0.3	0.3	-1.9	-1.5	-1.6	0.0	-0.8	-1.9
Hand grip strength (right)	0.8	2.3	5.6	0.8	-1.7	-1.5	-2.1	-0.8	-1.8	-2.4	-0.2	-0.9	-1.4	-2.3	-1.4	-0.3
Sitting height	0.8	6.0	16.5	4.0	-1.2	-4.1	-1.5	0.4	-3.2	-2.9	1.4	0.6	-1.8	-3.9	-1.2	1.2
Illnesses of siblings	0.8	1.2	3.6	-0.4	0.4	1.9	1.0	0.5	1.6	1.3	0.3	0.7	1.4	1.8	0.5	0.3
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	0.4	0.5	-0.6	0.8	0.9	0.8	1.4	0.8	0.9	1.5	1.4	0.9	0.7
Eye problems/disorders: None of the above	0.8	0.9	3.7	1.9	0.0	-0.2	-0.2	0.1	-1.6	-1.3	0.5	-0.0	-0.7	-1.7	-0.4	0.6
Comparative height size at age 10	0.8	4.7	10.3	0.4	-2.6	-1.0	-1.3	-1.9	-3.1	-3.1	-1.2	-2.0	-2.0	-3.2	-2.4	-1.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.7	-1.9	-0.4	0.8	1.1	-0.7	0.9	0.9	-1.1	-0.6	0.4	1.3	-0.2	-1.1
Ever had bowel cancer screening	0.8	0.9	2.4	-0.9	0.8	-0.0	1.6	0.8	1.3	1.4	0.6	0.7	0.3	0.9	1.5	0.4
Diabetes diagnosed by doctor	0.8	1.3	3.1	-1.3	1.3	0.9	0.3	0.7	1.6	1.8	0.3	0.9	0.3	1.8	1.4	0.3
Smoking status: Current	0.8	1.3	2.1	1.2	1.1	1.0	1.5	1.1	1.0	1.0	1.1	1.1	1.2	1.0	1.0	1.3
Commuting to job workplace: Public transport	0.8	0.9	1.8	-0.9	-0.6	0.7	-0.0	-1.2	-0.6	-0.7	-1.3	-1.3	-1.3	-0.8	-0.9	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	5.6	-1.6	-0.3	2.4	1.2	-0.6	0.8	0.0	-1.0	-0.5	0.2	0.3	-0.3	-0.8
Fractured/broken bones in last 5 years	0.8	1.1	2.4	1.0	0.7	-1.5	-0.9	1.0	1.0	1.0	0.9	1.0	1.2	1.1	0.7	1.1
Cholesterol lowering medication	0.8	1.2	5.8	-2.4	-0.9	0.0	-0.5	-1.2	0.2	0.5	-1.5	-0.9	-1.1	0.5	-0.6	-1.6
Pain experienced in last month	0.8	1.4	4.8	1.7	-0.6	-2.2	-1.4	-0.0	-1.2	-1.7	0.6	-0.2	-0.7	-1.4	-0.7	0.4
Hypothyroidism (self reported)	0.7	1.6	6.9	-0.7	-1.1	2.6	2.5	-0.9	0.3	-0.7	-1.0	-1.0	0.5	0.3	-1.0	-0.9
Hand grip strength (left)	0.7	1.9	4.4	0.8	-1.6	-0.6	-2.0	-0.8	-1.9	-2.1	-0.3	-0.8	-1.2	-2.1	-1.4	-0.4
Sensitivity / hurt feelings	0.7	1.2	2.4	-1.0	-1.3	0.3	0.1	-1.4	-0.9	-0.6	-1.6	-1.3	-1.2	-0.7	-1.4	-1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.6	1.0	1.2	0.1	0.1	1.2	0.3	1.0	1.2	1.2	-0.2	0.2	1.3	1.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.4	-2.1	-0.4	2.5	0.8	-1.1	0.0	0.4	-1.4	-1.1	-1.2	0.2	-0.5	-1.4
Body mass index (BMI)	0.7	3.0	5.7	-1.9	-1.8	-1.0	-0.7	-1.9	-1.6	-1.5	-2.1	-1.6	-2.4	-1.7	-1.8	-1.8
Number of incorrect matches in round	0.7	1.1	4.6	1.1	-0.1	-0.4	-1.2	-0.2	-1.7	-1.7	0.2	-0.7	-0.9	-2.1	-0.3	-0.0
Financial difficulties in last 2 years	0.7	0.9	2.3	-0.1	-1.1	-1.1	-0.6	-0.8	-1.0	-1.2	-0.7	-0.9	-1.5	-1.1	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.8	-0.0	1.2	0.9	1.3	0.9	0.9	1.0	0.6	0.9	0.8	0.8	1.2	0.8
Medication: Cholesterol lowering	0.7	1.0	3.1	-1.3	-1.0	-1.8	-0.7	-1.0	-0.6	-0.0	-1.2	-0.9	-1.1	0.1	-0.8	-1.1
Medication: Paracetamol	0.7	1.2	2.4	-0.9	-1.1	-0.0	-0.8	-1.3	-1.0	-0.7	-1.5	-1.2	-1.5	-0.9	-1.3	-1.3
Exposure to tobacco smoke outside home	0.7	1.0	2.6	1.0	1.0	1.6	-1.4	0.9	0.4	1.0	0.9	1.0	0.3	0.7	0.9	1.0
Worry too long after embarrassment	0.7	1.2	3.9	-2.0	-0.6	-0.2	1.5	-1.1	-0.5	-0.3	-1.4	-1.1	-1.0	-0.5	-0.6	-1.4
Miserableness	0.7	1.2	9.5	-0.0	0.5	-0.1	3.1	0.6	1.0	1.2	0.3	0.6	1.2	1.0	0.7	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	5.6	-0.7	0.1	1.7	2.4	0.0	1.0	0.5	-0.2	0.0	1.0	0.8	0.2	-0.1
Leg fat percentage (left)	0.7	2.6	7.1	-2.7	-1.3	0.1	-0.0	-1.9	-1.2	-0.7	-2.3	-1.8	-2.0	-0.9	-1.3	-2.0
Bipolar Disorder (2018)	0.6	1.0	2.4	-1.5	-1.4	-0.9	-0.2	-1.2	0.0	0.1	-1.4	-1.1	-0.2	0.5	-1.0	-1.4
Crohns Disease (2017)	0.6	1.3	2.5	-0.4	-1.3	-0.7	-0.7	-1.4	-1.2	-1.5	-1.2	-1.4	-0.7	-1.1	-1.6	-1.2
Multivitamins +/- minerals	0.6	0.8	1.7	0.8	1.1	-0.4	-0.6	0.9	0.6	1.1	0.9	0.8	1.3	1.1	0.9	0.9
Past tobacco smoking	0.6	1.2	4.7	-2.0	0.3	-0.4	0.1	-0.0	1.2	2.2	-0.7	0.4	0.5	1.9	0.6	-0.6
Nervous feelings	0.6	1.2	6.0	-2.4	-0.4	0.1	0.6	-0.8	1.1	1.0	-1.4	-0.6	-0.2	1.3	-0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	0.6	1.2	0.2	1.2	0.9	0.6	1.2	0.8	0.9	0.1	0.5	1.0	0.9
Mouth/teeth dental problems	0.6	1.0	2.5	0.3	-1.6	0.3	0.1	-0.8	-0.8	-1.5	-0.7	-0.8	-1.1	-1.4	-1.2	-0.6
Allergy	0.6	1.4	7.4	2.7	0.4	-1.4	-0.6	1.0	-0.6	-1.0	1.5	0.8	0.9	-0.8	0.3	1.3
Diabetes (self-reported)	0.6	0.9	2.2	-0.9	1.1	1.1	0.5	0.5	1.3	1.5	0.2	0.6	0.0	1.4	1.1	0.1
Impedance of arm (right)	0.6	2.6	8.1	-2.9	-0.2	2.6	1.3	-1.4	1.1	0.7	-1.7	-1.8	0.8	1.6	-0.3	-2.0
Noisy workplace	0.6	0.8	4.4	-0.4	-0.7	1.4	2.1	-0.3	0.1	0.8	-0.4	-0.2	0.5	1.2	-0.4	-0.4
Prospective memory result	0.6	0.7	2.0	-0.5	0.4	1.2	1.0	0.7	1.1	1.4	0.4	0.8	0.4	0.8	1.1	0.4
Length of working week for main job	0.6	0.7	5.8	-0.6	0.2	2.4	0.3	0.0	0.7	0.6	-0.2	0.1	0.9	1.0	-0.0	-0.1
Age at first live birth	0.6	1.0	3.3	-1.6	-0.1	0.6	1.3	-0.0	1.4	1.1	-0.5	0.1	1.3	1.8	0.3	-0.5
Shortness of breath walking on level ground	0.6	0.7	5.2	-1.2	-0.2	0.3	2.3	-0.2	0.7	0.6	-0.4	-0.3	0.7	0.9	0.3	-0.5
Mean time to correctly identify matches	0.6	1.1	1.8	-0.9	-0.8	0.5	1.3	-1.3	-0.8	-1.1	-1.3	-1.3	-0.8	-0.7	-1.3	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	-0.8	-1.1	0.6	0.8	-0.9	-0.4	-0.9	-0.9	-0.8	-0.8	-0.8	-0.8	-1.0
Myopia	0.6	0.9	3.0	-1.7	-0.8	-0.5	1.7	-0.9	0.4	-0.0	-1.1	-0.9	-0.1	0.6	-0.6	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.3	2.6	-0.6	-1.5	-1.3	-0.7	-1.3	-1.1	-1.2	-1.2	-1.3	-0.2	-0.6	-1.6	-1.2
Mean Putamen Volume	0.5	0.5	1.2	0.5	1.0	-0.8	-1.1	0.7	0.5	0.1	0.8	0.7	0.9	0.3	0.8	0.8
Primary Biliary Cirrhosis	0.5	0.8	1.9	-0.3	-0.8	0.4	-0.2	-0.8	-1.4	-0.8	-0.8	-0.7	-1.4	-1.2	-0.9	-0.8
Number of treatments/medications taken	0.5	0.9	3.1	-1.8	-0.0	-0.6	-0.2	-1.1	-0.5	0.6	-1.5	-1.0	-0.9	0.5	-0.4	-1.2
Diabetes (father)	0.5	0.6	1.8	-1.3	-0.6	-0.7	-0.9	-0.9	-0.1	-0.3	-0.9	-0.8	-1.1	-0.4	-0.5	-1.0
Townsend deprivation index at recruitment	0.5	0.7	2.0	-0.3	-0.9	1.4	0.6	-0.7	-0.8	-1.0	-0.7	-0.8	-0.9	-1.0	-0.8	-0.6
Current tobacco smoking	0.5	0.8	1.3	1.1	1.0	0.7	1.1	0.9	0.7	0.7	0.9	0.9	0.9	0.7	0.8	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.8	1.7	0.5	-1.6	-0.3	0.2	-1.2	0.1	0.5	-0.0	-0.3	-0.1	-0.3	0.5
High blood pressure	0.5	1.4	4.5	-2.1	-0.9	-0.2	-0.9	-1.5	-0.6	-0.0	-1.8	-1.4	-0.9	0.3	-1.0	-1.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.1	-0.7	-0.0	0.7	-1.0	-0.3	-0.3	-1.2	-0.8	-1.0	-0.6	-0.7	-1.0
Impedance of leg (left)	0.5	2.3	3.5	0.9	1.9	1.7	1.5	1.4	1.2	1.8	1.4	1.0	1.8	1.7	1.8	1.2
Forced vital capacity (FVC)	0.5	2.0	7.9	2.4	-0.4	0.5	-0.5	0.2	-2.2	-1.9	0.8	0.1	-1.2	-2.8	-0.6	0.8
Pain all over the body in last month	0.5	0.6	1.3	-0.4	-1.0	0.6	0.5	-0.8	-0.4	-1.1	-0.7	-0.9	-0.3	-0.7	-1.0	-0.7
Loud music exposure frequency	0.5	0.6	1.8	0.5	1.2	1.3	0.8	0.6	-0.2	0.8	0.4	0.7	-0.5	0.2	0.7	0.8
Comparative body size at age 10	0.5	1.3	2.2	-1.2	-1.5	-0.6	-0.4	-1.4	-0.5	-1.4	-1.3	-1.4	-1.1	-0.9	-1.3	-1.4
Emphysema/chronic bronchitis	0.5	0.6	4.0	-0.3	-0.5	-2.0	-0.2	-0.5	-0.9	-0.7	-0.4	-0.7	-0.8	-0.5	-0.4	-0.5
Medication: Blood pressure	0.5	0.8	2.2	-1.5	-0.9	-1.2	-0.6	-1.0	-0.4	0.2	-1.3	-0.8	-0.6	0.4	-0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.5	-0.6	1.0	0.1	-0.6	0.6	1.1	1.1	0.4	0.4	1.0	1.2	1.1	0.2
Supplements: Vitamin C	0.5	0.6	1.5	-0.6	-0.9	-0.5	-0.4	-0.8	-1.0	-0.7	-0.7	-0.8	-1.2	-0.8	-0.6	-0.9
Mood swings	0.5	1.0	6.3	1.6	0.1	-2.5	-0.3	0.2	-1.0	-0.6	0.4	0.2	0.1	-1.1	-0.4	0.7
Mineral and other dietary supplements	0.5	0.7	3.0	-0.1	-0.7	-1.7	-0.9	-0.5	-1.1	-0.9	-0.3	-0.5	-1.0	-0.9	-0.6	-0.5
Ever smoked	0.5	0.8	3.5	1.2	-0.6	0.5	0.3	-0.5	-1.0	-1.9	-0.1	-0.8	-0.6	-1.3	-0.9	0.1
Number of operations (self-reported)	0.5	0.8	1.3	-0.2	-1.1	-0.4	-1.1	-1.0	-1.0	-1.1	-0.9	-1.1	-0.2	-0.7	-1.1	-0.8
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.6	-0.8	1.1	1.3	-1.0	-0.6	-0.3	-1.0	-1.0	-0.4	-0.1	-1.0	-0.9
Schizophrenia (2018)	0.4	0.9	2.4	0.5	-0.7	-0.9	-0.8	-0.8	-1.5	-1.6	-0.4	-0.8	-0.0	-1.2	-1.2	-0.4
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	-0.1	-0.8	-0.2	-0.3	-1.0	-1.3	-1.5	-0.7	-1.2	-0.7	-1.4	-1.0	-0.8
Ovarian Cancer	0.4	0.6	2.0	0.7	-0.0	-0.8	-1.4	-0.1	-0.8	-1.3	0.1	-0.3	0.0	-1.3	-0.5	0.2
Age at First Birth	0.4	0.6	2.0	-0.8	0.7	-1.1	0.4	0.2	0.8	1.2	-0.0	0.3	0.3	1.4	0.7	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	2.6	0.6	-0.6	-1.6	-0.8	0.1	-0.8	-1.1	0.4	-0.1	-0.2	-1.1	-0.3	0.2
Waist Hip Ratio (WHR)	0.4	1.7	7.3	-1.2	0.4	1.4	2.0	-0.1	1.2	2.1	-0.4	-0.0	0.9	2.7	0.5	-0.4
Cardiovascular Disease	0.4	1.2	3.7	-1.9	-0.5	-1.0	-1.2	-1.2	-0.1	0.7	-1.6	-1.0	-0.3	1.2	-0.8	-1.4
Impedance of leg (right)	0.4	1.9	3.5	0.2	1.7	1.5	1.5	1.0	1.2	1.9	1.0	0.8	1.6	1.8	1.6	0.8
Relative age voice broke	0.4	0.6	1.9	-1.1	0.1	1.2	-0.1	-0.2	0.9	1.2	-0.4	-0.3	0.6	1.4	0.3	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	3.7	0.4	0.3	-0.4	1.9	0.4	-0.2	0.9	0.3	0.6	-0.6	0.0	0.2	0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	1.2	0.2	1.2	1.3	0.7	0.2	0.3	1.0	0.6	0.4	0.4	0.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	6.1	2.1	-0.1	-0.1	-0.1	0.2	-1.8	-1.7	0.8	-0.0	-1.0	-2.5	-0.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.2	-0.7	-0.4	0.3	1.5	-0.8	-0.3	-0.0	-0.9	-0.8	0.0	0.6	-0.7	-0.7
Impedance of arm (left)	0.4	1.8	6.4	-1.8	0.4	2.5	1.8	-0.6	1.3	0.8	-0.7	-1.1	1.6	1.6	0.4	-1.1
Breastfed as a baby	0.4	0.5	2.7	-0.3	-0.2	0.4	0.2	-0.3	-1.0	-0.8	-0.1	-0.6	-1.6	-1.2	0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.0	-0.6	-0.2	1.4	-0.7	0.4	1.3	1.1	0.1	0.5	0.7	1.4	0.4	0.2
Blood clot in the leg (DVT)	0.4	0.5	1.7	0.5	0.6	0.5	0.3	0.6	0.7	1.3	0.3	0.7	0.7	1.2	0.4	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.8	-0.7	0.2	1.7	0.6	0.1	0.4	0.9	-0.2	0.3	-0.9	0.8	0.2	-0.1
Wheeze or whistling in the chest in last year	0.4	0.8	6.1	-0.2	1.2	2.5	0.2	0.5	0.7	0.6	0.3	0.6	-0.3	0.1	0.7	0.6
Medication: Ibuprofen	0.4	0.5	1.2	-0.2	1.0	1.0	0.7	0.6	0.5	1.1	0.4	0.6	0.4	0.7	1.0	0.5
Alcohol intake frequency.	0.4	0.9	2.5	-0.9	0.1	0.7	1.6	0.4	1.4	1.6	-0.1	0.6	0.5	1.5	0.6	0.1
Chest pain or discomfort	0.4	0.5	3.0	0.7	0.6	-1.7	-0.9	0.2	-0.6	-0.2	0.4	0.0	-1.0	-0.7	0.2	0.4
Age at last live birth	0.4	0.6	1.8	-0.7	0.1	1.4	0.8	0.4	1.2	1.0	0.1	0.6	0.5	1.1	0.6	0.1
Family relationship satisfaction	0.4	0.5	2.1	-0.4	0.0	1.0	0.4	0.2	0.8	1.4	-0.0	0.5	0.1	1.3	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	0.9	0.6	0.2	-0.1	0.8	0.3	0.4	0.7	0.9	0.7	0.4	0.4	0.9
Mother’s age at death	0.4	0.5	1.1	-0.5	-0.7	-0.4	0.4	-0.7	-0.9	-1.0	-0.6	-0.9	-0.2	-0.8	-0.5	-0.8
Medication: Blood pressure	0.4	0.7	4.0	-2.0	-0.1	0.1	-0.7	-0.8	0.4	0.7	-1.2	-0.6	-0.4	0.8	-0.2	-1.0
High cholesterol (Self-reported)	0.4	0.7	2.6	-1.6	-0.6	-1.1	-0.9	-0.7	-0.2	0.6	-0.9	-0.6	-1.1	0.3	-0.2	-1.1
Medication: Lisinopril	0.4	0.5	1.5	-0.4	-0.1	1.2	-1.2	-0.5	-0.7	0.1	-0.6	-0.5	-1.2	-0.1	-0.3	-0.5
Impedance of whole body	0.4	2.2	6.4	-0.6	1.5	2.5	1.9	0.6	1.6	1.7	0.5	0.1	1.9	2.0	1.4	0.1
Depressed Affect (Nagel 2018)	0.3	0.6	4.0	0.5	0.6	-2.0	0.9	0.5	0.1	0.9	0.3	0.8	0.3	0.1	0.4	0.6
Alzheimer’s Disease (in mother)	0.3	0.4	3.5	-0.2	0.3	-1.9	-0.3	0.2	-0.4	-0.0	0.2	0.3	-0.5	-0.8	0.3	-0.0
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.6	-0.9	-0.2	0.9	-0.6	0.2	-0.6	-0.6	-0.7	0.5	0.2	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	3.7	-0.4	-0.4	-1.9	0.4	-0.3	-0.4	-0.6	-0.3	-0.4	-0.3	-0.8	-0.2	-0.5
Reaction Time	0.3	0.6	2.5	-0.0	-0.3	1.6	1.5	-0.7	-0.4	-0.7	-0.6	-0.7	-0.3	-0.3	-0.8	-0.5
Breast Cancer	0.3	0.7	1.5	0.3	1.2	0.4	-0.8	1.0	0.8	0.3	0.9	1.0	0.6	-0.1	1.2	1.1
Crohns Disease (2012)	0.3	0.5	3.5	0.7	-0.0	-1.9	-0.1	0.1	-0.6	-0.5	0.4	0.1	-0.7	-0.7	-0.2	0.2
Schizophrenia (2014)	0.3	0.8	2.5	-0.1	-0.8	-1.0	-1.6	-0.8	-1.0	-1.0	-0.6	-0.8	-0.1	-0.8	-1.0	-0.6
Triglycerides	0.3	0.5	2.0	-1.2	-0.3	-0.6	-1.4	-0.6	-0.1	0.3	-0.8	-0.3	-0.7	0.2	-0.4	-0.7
Smoking Status	0.3	0.7	3.2	1.8	0.7	0.3	1.2	0.8	-0.0	-0.2	1.0	0.8	0.6	-0.1	0.2	1.2
Lung FVC	0.3	1.7	4.9	1.3	1.3	2.2	1.7	1.4	0.1	-0.0	1.5	1.2	0.5	-0.7	1.3	1.5
Tanning	0.3	3.7	7.2	2.2	2.3	1.0	-0.2	2.5	1.5	1.5	2.4	2.6	1.3	1.1	2.0	2.7
Systolic blood pressure, automated reading	0.3	0.8	4.7	-1.5	0.2	-1.2	-2.2	-0.4	0.4	0.6	-0.9	-0.3	0.0	0.7	0.1	-0.6
Supplements: Zinc	0.3	0.3	1.3	1.1	0.4	1.1	-0.8	0.3	-0.5	-0.2	0.5	0.2	-0.0	-0.3	-0.0	0.5
Medication: Metformin	0.3	0.4	2.4	-1.6	0.1	0.0	-0.9	-0.1	0.8	0.2	-0.2	-0.3	-0.0	0.5	0.6	-0.7
Age when periods started (menarche)	0.3	0.8	4.2	2.0	0.4	-0.3	-1.0	0.9	-0.1	0.0	1.2	0.9	0.3	-0.1	0.2	1.2
Supplements: Glucosamine	0.3	0.4	2.3	-0.1	0.2	0.6	1.5	0.3	1.0	0.6	0.2	0.4	0.7	0.8	0.3	0.2
Hearing difficulty/problems with background noise	0.3	0.5	2.5	-1.0	0.3	1.6	0.8	-0.5	-0.3	-0.0	-0.7	-0.5	-0.8	-0.2	0.1	-0.6
Had other major operations	0.3	0.4	0.9	-0.4	-0.7	0.8	-0.2	-0.7	-1.0	-0.4	-0.6	-0.8	-0.4	-0.5	-0.5	-0.7
Fluid intelligence score	0.3	0.6	4.0	-2.0	-0.1	0.3	0.2	-0.4	0.7	0.9	-0.8	-0.3	-0.2	0.9	0.1	-0.8
Father’s age at death	0.3	0.4	2.2	-0.7	0.4	1.5	-0.3	0.0	1.0	0.4	-0.2	-0.2	0.6	0.9	0.3	-0.1
Falls in the last year	0.3	0.3	2.1	-0.7	-0.1	1.5	0.6	-0.5	-0.1	-0.2	-0.7	-0.5	0.1	0.0	-0.4	-0.5
Medication: Lansoprazole	0.3	0.3	0.7	0.8	0.7	0.1	0.6	0.7	0.1	-0.3	0.8	0.3	0.7	-0.2	0.6	0.7
Tense / ‘highly strung’	0.3	0.5	2.0	-0.2	1.0	-1.4	1.4	0.3	0.0	0.7	0.2	0.3	-0.5	-0.0	0.7	0.2
Birth weight of first child	0.3	0.6	3.7	-0.3	-0.9	-1.9	0.1	-0.6	-0.9	-0.4	-0.5	-0.6	-0.6	-0.3	-0.5	-0.7
Pulse wave reflection index	0.3	0.4	1.7	0.1	-0.4	-1.2	-1.3	-0.4	-0.9	-0.2	-0.2	-0.3	-0.2	-0.1	-0.5	-0.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.4	-0.7	-0.6	-0.1	-0.6	-0.5	-0.8	-0.4	-0.5	-0.5	-1.2	-0.7	-0.3	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.1	4.5	1.1	-0.3	1.7	-0.2	0.1	-1.3	-1.4	0.5	-0.0	-0.9	-2.1	-0.3	0.4
Migraine (self-reported)	0.3	0.4	1.7	-0.5	0.5	0.8	0.9	0.2	0.5	0.3	0.0	0.2	1.3	0.7	0.4	0.1
Medication: Seretide 50 evohaler	0.3	0.4	3.2	0.1	0.2	-1.8	-1.0	0.0	0.2	0.4	-0.1	0.2	0.1	0.0	-0.0	0.0
Suffer from ‘nerves’	0.3	0.5	2.3	-1.1	-0.2	0.3	1.5	-0.6	0.0	-0.0	-0.8	-0.4	-1.0	-0.3	-0.4	-0.6
Overall health rating	0.3	0.7	1.9	-1.4	-0.5	0.5	-0.2	-0.9	0.0	0.9	-1.2	-0.6	-1.0	0.6	-0.6	-1.0
Hypertension (Self-reported)	0.3	0.9	4.2	-2.0	-0.4	-0.1	-0.9	-1.0	-0.2	0.5	-1.4	-0.8	-0.6	0.7	-0.5	-1.3
Medication: Gliclazide	0.3	0.3	1.7	-1.1	0.6	-1.3	0.0	-0.0	0.5	0.3	-0.2	0.1	-0.3	0.3	0.4	-0.2
Medication: Paracetamol	0.3	0.5	1.4	-1.2	-0.2	1.0	0.0	-0.8	-0.0	0.3	-1.1	-0.6	-0.8	0.1	-0.5	-0.9
Irritability	0.3	0.6	1.0	0.3	1.0	-0.8	0.2	0.8	0.9	0.9	0.6	0.8	1.0	0.7	0.9	0.7
Diastolic blood pressure, automated reading	0.3	0.9	2.7	-1.5	0.5	-0.1	-0.9	0.2	0.9	1.7	-0.4	0.4	1.0	1.6	0.7	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.9	-0.9	0.1	-0.0	1.7	-0.3	0.2	0.2	-0.3	-0.4	-0.0	0.3	0.2	-0.5
Depression (Nagel 2018)	0.2	0.3	2.0	-0.1	0.2	0.6	1.4	-0.1	0.4	0.3	-0.4	0.1	0.4	0.4	-0.3	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	-1.3	0.4	-1.0	-0.3	0.1	0.9	1.5	-0.3	0.3	0.2	1.1	0.6	-0.2
Neuroticism (Nagel 2018)	0.2	0.4	4.1	-0.3	0.1	-2.0	0.4	0.1	-0.1	0.5	-0.1	0.3	-0.5	-0.3	0.3	0.1
Worry (Nagel 2018)	0.2	0.4	2.0	-1.4	0.2	-1.1	0.6	-0.4	0.2	0.4	-0.8	-0.4	-0.6	0.1	0.1	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.1	-0.3	0.7	0.1	-0.4	-0.9	-1.1	-0.1	-0.7	-0.1	-1.2	-0.2	-0.3
Fasting Glucose	0.2	0.2	1.0	-0.0	0.4	-0.7	-0.5	0.4	0.4	1.0	0.1	0.4	-0.1	0.6	0.4	0.2
HDL Cholesterol	0.2	0.4	1.3	0.5	0.2	1.2	-0.0	0.7	0.7	0.0	0.9	0.5	0.7	0.1	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.1	0.4	0.2	-1.1	0.6	-0.2	-0.6	-0.1	-0.3	-0.2	-0.2	-0.4	-0.5	-0.1
Systolic Blood Pressure	0.2	1.1	3.0	-1.1	0.2	-1.7	-1.7	-0.5	0.8	0.8	-0.7	-0.5	1.2	1.6	-0.2	-0.7
Respiratory disease	0.2	0.4	1.8	-1.1	0.2	1.4	-0.2	-0.2	0.2	0.8	-0.5	-0.0	-0.3	0.6	0.0	-0.3
Lung FEV1/FVC ratio	0.2	0.9	5.2	-0.5	-0.2	-2.3	0.0	-0.8	-0.5	-1.4	-0.6	-1.1	-0.1	-1.0	-0.4	-0.7
Neuroticism	0.2	0.5	2.3	-0.1	0.9	-1.5	0.8	0.5	0.3	1.1	0.2	0.7	-0.1	0.1	0.7	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.8	-0.6	-0.4	-1.3	0.6	-0.6	-0.0	-0.2	-0.8	-0.5	-0.2	-0.2	-0.6	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.6	-0.6	-0.7	-0.3	-0.6	-0.6	-0.3	-0.7	-0.3	-0.8	-0.5	-0.5	-0.6
Medication: Co-codamol	0.2	0.3	0.7	-0.5	-0.1	0.7	-0.1	-0.5	-0.8	-0.1	-0.4	-0.7	-0.7	-0.4	-0.1	-0.5
Pack years adult smoking proportion	0.2	0.3	1.1	0.8	-0.5	-1.1	0.0	-0.2	-0.5	-0.1	-0.1	0.0	-1.0	-0.5	-0.5	-0.0
Average weekly fortified wine intake	0.2	0.3	1.0	0.1	1.0	-0.5	0.0	0.5	0.2	0.3	0.5	0.4	0.6	0.4	0.7	0.4
Alcohol usually taken with meals	0.2	0.4	2.5	-1.6	-0.1	0.2	0.3	-0.4	-0.2	-0.4	-0.6	-0.3	-0.9	-0.5	0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	-0.3	-0.4	-0.1	0.8	-0.8	-0.4	-0.6	-0.8	-0.9	-0.3	-0.4	-0.8	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	1.5	0.5	-0.2	-1.2	-0.6	0.0	-0.2	-0.0	0.0	0.3	0.5	-0.0	-0.3	0.3
Medication: Simvastatin	0.2	0.2	0.9	-0.9	-0.1	-0.4	-0.7	-0.2	0.1	0.8	-0.4	-0.2	-0.3	0.6	0.2	-0.4
Happiness	0.2	0.3	0.9	0.4	0.3	-0.7	-0.6	0.5	0.3	1.0	0.5	0.7	0.1	0.6	0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.6	2.3	-0.2	0.2	0.4	-0.2	0.4	1.3	1.3	0.2	0.4	0.9	1.5	0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.1	1.1	0.1	1.4	0.1	0.3	-0.7	-1.1	0.7	0.1	-0.3	-1.4	0.1	0.5
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.4	0.5	0.8	0.3	0.4	0.6	-0.0	0.5	0.4	0.8	-0.1	0.3	0.6
Glaucoma (self-reported)	0.2	0.3	2.6	0.0	-0.3	-0.4	1.6	-0.1	0.1	-0.1	-0.1	0.1	0.6	0.4	-0.4	0.0
Birth weight	0.2	0.5	2.0	1.4	-0.1	-0.6	-0.2	0.3	-0.6	-1.0	0.6	0.2	-0.6	-1.1	-0.2	0.6
Health satisfaction	0.2	0.3	1.2	-0.3	0.3	-1.1	0.7	0.3	-0.0	1.1	0.2	0.3	0.1	0.5	0.6	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	0.3	0.6	0.3	0.9	0.2	-0.5	-0.0	0.3	0.2	-0.7	-0.3	0.1	0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	1.2	0.1	0.3	0.2	0.8	0.3	-0.1	1.0	0.8	0.9	0.1	0.3	0.8
Leg pain on walking	0.2	0.2	0.9	-0.1	-0.9	0.4	0.1	-0.5	-0.5	-0.4	-0.6	-0.4	-0.4	-0.6	-0.6	-0.3
Friendships satisfaction	0.2	0.2	1.2	0.1	-0.5	-0.6	-1.1	-0.2	-0.3	0.0	-0.2	0.0	-0.9	-0.2	-0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.2	-0.4	0.8	0.2	-0.2	0.3	0.4	1.1	0.2	0.3	0.8	1.0	0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.6	0.5	0.2	1.3	-0.7	0.3	0.3	0.5	0.3	0.2	0.6	0.4	0.2	0.3
Eye problems/disorders: Glaucoma	0.2	0.2	1.7	0.2	-0.4	-0.0	1.3	-0.1	0.0	0.1	-0.1	0.0	0.5	0.4	-0.3	-0.1
Illnesses of father: High blood pressure	0.2	0.3	1.7	0.1	-0.3	-1.3	-1.1	-0.2	-0.3	-0.6	-0.1	-0.4	0.1	-0.2	-0.2	-0.1
Pack years of smoking	0.2	0.3	1.6	0.4	-0.7	-1.3	-0.1	-0.2	-0.2	0.1	-0.2	-0.1	-0.8	-0.2	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	2.5	-1.6	-0.2	-0.3	0.0	-0.3	0.4	0.6	-0.5	-0.3	0.2	0.6	0.3	-0.7
HbA1C	0.1	0.2	1.0	-0.2	0.1	-0.0	-1.0	-0.1	0.3	0.6	-0.4	-0.1	-0.3	0.4	-0.5	-0.1
Ulcerative Colitis	0.1	0.2	0.4	0.5	0.2	0.2	0.7	0.3	-0.6	-0.3	0.5	0.0	-0.4	-0.6	0.4	0.4
Blood Red Count	0.1	1.4	5.0	0.1	1.6	0.3	-0.5	1.3	0.4	2.2	1.0	1.4	0.2	1.2	1.7	0.9
BMI	0.1	0.8	1.4	-1.2	-1.2	0.3	-0.6	-1.0	-0.6	-0.5	-1.1	-0.7	-1.1	-0.5	-1.0	-0.9
Chronotype (morning person)	0.1	0.3	0.9	0.1	0.1	-0.9	-0.5	-0.2	-0.8	-0.1	-0.2	-0.3	-0.9	-0.8	-0.1	-0.2
Hair Pigment	0.1	3.7	7.8	-1.7	-1.9	-1.5	-0.0	-2.3	-2.0	-2.1	-2.0	-2.8	-1.7	-1.7	-1.6	-2.5
Relative age of first facial hair	0.1	0.2	0.8	-0.1	-0.0	-0.2	0.2	-0.4	-0.9	-0.2	-0.3	-0.5	-0.5	-0.5	-0.2	-0.6
Vitamin and mineral supplements	0.1	0.2	1.0	-0.5	0.0	0.5	-0.4	-0.2	-0.1	-0.3	-0.3	-0.1	-1.0	-0.6	-0.2	-0.2
Fed-up feelings	0.1	0.2	1.4	0.1	0.3	-1.2	0.4	-0.2	-0.7	0.1	-0.2	0.0	-0.4	-0.6	-0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.3	0.5	0.3	0.7	-0.0	-0.2	-0.2	-0.1	-0.1	0.0	-0.3	0.0	0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.7	-0.1	0.1	0.7	0.2	-0.2	-0.0	0.3	0.3	-0.1	-0.3	-0.1	0.4
Had menopause	0.1	0.1	0.7	-0.5	-0.5	0.3	0.3	-0.1	0.8	0.0	-0.2	-0.0	0.5	0.3	-0.0	-0.2
Qualifications: None of the above	0.1	0.3	1.5	1.2	0.2	-0.2	0.6	0.2	-0.6	-0.2	0.5	0.3	-0.3	-0.7	-0.0	0.3
Medication: Ramipril	0.1	0.1	0.4	-0.3	0.3	0.3	0.3	-0.2	-0.7	0.1	-0.3	-0.3	-0.6	-0.4	0.0	-0.3
Neuroticism score	0.1	0.2	1.3	-0.6	0.6	-0.7	1.1	-0.0	0.2	0.6	-0.3	-0.0	0.2	0.2	0.3	-0.2
Time employed in main current job	0.1	0.1	0.5	0.3	-0.1	0.1	-0.2	-0.0	0.5	0.1	0.1	-0.3	0.7	0.6	-0.0	-0.0
Worrier / anxious feelings	0.1	0.2	1.8	0.2	-0.2	-1.3	0.3	-0.3	-0.4	-0.2	-0.2	-0.6	0.3	-0.1	-0.3	-0.3
Asthma	0.1	0.2	1.7	-1.3	-0.0	0.5	0.0	-0.3	0.6	0.0	-0.7	-0.2	0.1	0.3	-0.1	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	-0.7	0.2	0.1	0.0	-0.2	0.5	0.4	-0.4	-0.3	0.3	1.1	0.1	-0.3
High blood pressure (siblings)	0.1	0.1	0.4	-0.0	0.1	-0.4	-0.4	0.2	-0.2	-0.0	0.1	0.1	-0.6	-0.5	0.4	0.2
Qualifications: College or University degree	0.1	0.4	1.2	-0.8	-0.4	-0.6	-0.4	-0.6	-0.5	0.0	-0.7	-0.6	-1.1	-0.2	-0.4	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	-0.2	0.5	-0.3	0.7	0.2	-0.2	-0.4	0.2	0.3	0.1	-0.6	0.2	0.2
Average weekly red wine intake	0.1	0.2	1.5	0.1	0.0	-1.2	-0.1	-0.0	-0.3	0.1	0.1	-0.1	-0.7	-0.1	0.1	-0.0
Qualifications: nursing, teaching	0.1	0.2	1.0	-0.6	-0.1	0.2	-1.0	-0.0	0.5	0.1	-0.1	-0.1	0.6	0.6	0.3	-0.2
Back pain experienced in last month	0.1	0.1	0.6	-0.1	-0.3	0.4	0.8	-0.1	0.1	0.1	-0.1	-0.1	-0.1	0.0	0.0	-0.1
Asthma (self-reported)	0.1	0.2	1.5	-1.2	-0.0	0.2	0.0	-0.4	0.5	-0.0	-0.7	-0.3	0.0	0.3	-0.2	-0.3
Guilty feelings	0.1	0.2	0.5	-0.6	-0.4	0.3	0.2	-0.5	-0.3	-0.7	-0.5	-0.5	-0.0	-0.6	-0.3	-0.5
Hearing aid user	0.1	0.2	0.7	-0.5	-0.7	-0.4	-0.8	-0.3	0.2	-0.1	-0.4	-0.0	0.1	0.2	-0.4	-0.4
Financial situation satisfaction	0.1	0.1	0.6	0.2	0.3	0.2	0.0	-0.0	-0.3	0.1	0.1	-0.0	-0.8	-0.2	0.1	0.1
Unable to work because of sickness or disability	0.1	0.1	1.0	-0.1	-0.0	1.0	0.5	0.1	0.3	0.6	-0.0	0.2	-0.2	0.4	0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	0.3	0.3	0.4	-0.3	0.2	0.2	0.8	0.0	0.3	0.1	0.6	0.1	0.3
Mouth/teeth dental problems: Dentures	0.0	0.1	0.5	0.3	-0.0	-0.7	-0.1	-0.0	-0.2	-0.4	0.1	-0.1	-0.1	-0.2	-0.2	0.2
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.5	0.3	-0.3	0.3	0.2	0.2	0.5	0.1	0.3	-0.5	-0.1	0.4	0.1

Hub : Genes

USP39

Models

Trait associations