TWAS
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Usage
Models
Genes
Traits
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Traits
:
Whole body fat-free mass
:
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chr3:171,064,766-172,924,003
Best TWAS P=3.77e-18 · Best GWAS P=2.83e-28 conditioned to 1.25e-09
171M
171.5M
172M
172.5M
173M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
FNDC3B
0.07
0.06
enet
8
0.05
3.2e-07
-9.24
8.7
3.8e-18
0.04
0.97
0.00
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
FNDC3B
0.07
0.02
enet
6
0.02
3.9e-03
7.65
-7.8
4.6e-15
-0.83
0.01
0.98
TRUE
3
YFS
Blood
TNFSF10
0.09
0.04
bslmm
462
0.08
1.6e-24
7.28
7.1
1.2e-12
0.38
1.00
0.00
TRUE
2
GTEx
Ovary
TNFSF10
0.40
0.01
lasso
10
0.05
1.8e-02
0.95
6.3
3.4e-10
0.41
0.03
0.49
TRUE