[Hub]/) : Traits : Whole body fat-free mass : ← →

chr4:105,373,669-107,092,169

Best TWAS P=7.2e-25 · Best GWAS P=1.19e-27 conditioned to 1.56e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -6.9 -7.5 7.1e-14 0.61 0.07 0.90 FALSE
2 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -10.6 -7.7 1.5e-14 0.58 0.06 0.45 FALSE
3 GTEx Brain Cerebellum PPA2 0.22 0.01 lasso 4 0.03 3.7e-02 -7.5 -6.1 1.0e-09 0.55 0.09 0.15 FALSE
4 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -8.8 -8.9 8.1e-19 0.79 0.05 0.64 FALSE
5 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -7.0 -7.6 2.9e-14 0.59 0.40 0.15 FALSE
6 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -10.6 -10.3 7.2e-25 0.81 0.03 0.94 TRUE
7 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 7.9 -9.0 2.3e-19 0.68 0.06 0.93 FALSE
8 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -8.9 -6.9 6.2e-12 0.70 0.23 0.40 FALSE
9 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -8.7 -6.1 1.0e-09 0.67 0.80 0.20 FALSE
10 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -7.5 -7.2 5.6e-13 0.63 0.43 0.36 FALSE
11 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -7.5 -8.6 5.4e-18 0.72 0.05 0.71 FALSE
12 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -10.8 -7.0 1.9e-12 0.58 0.02 0.92 FALSE
13 GTEx Thyroid PPA2 0.22 0.01 enet 18 0.12 2.9e-09 5.7 -5.6 2.3e-08 0.50 0.73 0.08 FALSE
14 YFS Blood PPA2 0.22 0.05 lasso 19 0.12 9.7e-38 -3.2 5.5 5.0e-08 -0.40 1.00 0.00 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -8.7 -8.0 1.5e-15 0.74 0.14 0.65 FALSE