TWAS
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Models
Genes
Traits
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Traits
:
Whole body fat-free mass
:
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chr4:144,882,744-146,788,825
Best TWAS P=6.66e-37 · Best GWAS P=1.33e-45 conditioned to 0.631
145M
145.5M
146M
146.5M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
OTUD4
0.04
0.03
lasso
2
0.03
1.4e-04
12.5
-12.7
6.7e-37
-0.85
0.15
0.78
TRUE
3
GTEx
Pancreas
ANAPC10
0.14
0.10
lasso
3
0.10
4.3e-05
-12.5
12.2
1.9e-34
0.60
0.33
0.10
TRUE
2
GTEx
Brain Hypothalamus
HHIP-AS1
0.12
0.02
enet
16
0.04
4.6e-02
9.3
9.4
6.9e-21
0.21
0.06
0.24
TRUE
1
CommonMind
Brain Pre-frontal Cortex
OTUD4
0.06
0.04
bslmm
272
0.04
2.6e-05
-11.1
-8.8
1.2e-18
-0.39
0.49
0.44
FALSE