Best TWAS P=2.81e-38 · Best GWAS P=1.57e-30 conditioned to 0.00515
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CTPS1 | 0.10 | 0.00 | enet | 8 | 0.00 | 4.6e-01 | 8.81 | 9.3 | 1.0e-20 | 0.75 | 0.05 | 0.60 | FALSE |
| 2 | GTEx | Artery Coronary | CTPS1 | 0.25 | -0.01 | enet | 23 | 0.00 | 3.0e-01 | 0.74 | 5.7 | 1.1e-08 | 0.39 | 0.07 | 0.13 | FALSE |
| 3 | GTEx | Brain Cerebellum | FOXO6 | 0.35 | 0.33 | enet | 21 | 0.36 | 1.2e-11 | 3.33 | 5.7 | 1.4e-08 | -0.01 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | CTPS1 | 0.12 | -0.01 | lasso | 4 | -0.01 | 7.5e-01 | 8.14 | 7.1 | 1.3e-12 | 0.61 | 0.04 | 0.10 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | CTPS1 | 0.26 | 0.11 | lasso | 6 | 0.08 | 1.6e-03 | 9.18 | 8.7 | 2.5e-18 | 0.70 | 0.19 | 0.36 | FALSE |
| 6 | GTEx | Lung | CTPS1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.4e-04 | 9.40 | 9.9 | 5.6e-23 | 0.77 | 0.22 | 0.63 | FALSE |
| 7 | GTEx | Nerve Tibial | SCMH1 | 0.16 | 0.03 | enet | 24 | 0.07 | 1.6e-05 | 11.07 | -10.2 | 1.7e-24 | -0.70 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Testis | SLFNL1 | 0.30 | 0.17 | lasso | 14 | 0.28 | 5.3e-13 | 11.32 | 8.2 | 3.1e-16 | 0.85 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Testis | CTPS1 | 0.57 | 0.28 | enet | 17 | 0.38 | 1.0e-17 | -3.67 | 6.1 | 8.3e-10 | 0.48 | 0.97 | 0.03 | FALSE |
| 10 | METSIM | Adipose | CTPS1 | 0.11 | 0.09 | enet | 31 | 0.09 | 6.2e-14 | -3.67 | 5.4 | 7.3e-08 | 0.28 | 1.00 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | CTPS1 | 0.04 | 0.04 | enet | 7 | 0.04 | 9.1e-06 | 8.10 | 6.0 | 1.5e-09 | 0.59 | 0.60 | 0.16 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLFNL1 | 0.03 | 0.01 | enet | 6 | 0.02 | 5.6e-05 | -1.19 | 6.0 | 1.9e-09 | 0.58 | 0.11 | 0.74 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CTPS | 0.05 | 0.04 | blup | 49 | 0.03 | 1.0e-04 | -3.67 | 5.4 | 7.5e-08 | 0.33 | 0.13 | 0.08 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCMH1 | 0.04 | 0.01 | enet | 7 | 0.02 | 2.5e-03 | 0.27 | -7.8 | 9.2e-15 | -0.70 | 0.01 | 0.82 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCMH1 | 0.03 | 0.03 | lasso | 2 | 0.02 | 6.2e-03 | 11.48 | -11.5 | 1.6e-30 | -1.00 | 0.01 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SCMH1 | 0.35 | 0.14 | blup | 96 | 0.14 | 1.5e-05 | -5.28 | 6.8 | 1.4e-11 | 0.47 | 0.17 | 0.26 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | SCMH1 | 0.07 | 0.08 | blup | 97 | 0.07 | 2.5e-07 | 11.05 | -12.9 | 2.8e-38 | -0.75 | 0.19 | 0.81 | TRUE |