TWAS hub - SLFNL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.140	0.0510	1.7e-03	0.076	NA	0.047	NA	0.037	9.1e-05	NA	1.8e-03	NA	5.0e-03
2	GTEx	Artery Aorta	0.142	0.0500	6.4e-04	0.082	NA	0.003	NA	0.029	2.9e-05	NA	2.0e-01	NA	9.8e-03
3	GTEx	Esophagus Mucosa	0.088	0.0330	7.5e-04	0.058	NA	0.047	NA	0.063	1.0e-04	NA	4.2e-04	NA	5.0e-05
4	GTEx	Testis	0.299	0.0660	1.8e-07	0.173	NA	0.263	NA	0.283	4.0e-08	NA	4.7e-12	NA	5.3e-13
5	ROSMAP	Brain Pre-frontal Cortex	0.212	0.0510	6.8e-11	0.151	0.083	0.195	0.205	0.200	5.5e-19	7.2e-11	1.7e-24	8.7e-26	4.2e-25
6	TCGA	Breast Invasive Carcinoma	0.027	0.0128	1.2e-04	0.015	0.015	0.019	NA	0.016	3.9e-04	3.4e-04	5.6e-05	NA	2.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Commuting to job workplace: Public transport	6.1	7.3	13.1	-3.0	-3.6	-2.7	-0.9	-2.1	-3.0
Hand grip strength (right)	5.4	14.7	36.1	2.8	3.1	1.1	6.0	2.3	5.3
Comparative height size at age 10	5.4	30.0	104.0	1.6	0.8	-3.2	10.2	3.1	7.3
Height	5.2	100.3	313.3	3.0	4.2	-2.3	17.7	7.8	14.0
Commuting to job workplace: Car/motor vehicle	4.7	5.3	9.9	1.8	3.2	2.5	0.3	2.6	2.5
Systolic blood pressure, automated reading	4.5	13.0	22.8	-2.0	-2.9	-2.0	-4.6	-4.2	-4.8
Standing height	4.3	42.4	141.6	1.1	2.1	-2.9	11.9	4.2	9.0
Systolic Blood Pressure	4.2	21.1	37.9	-3.3	-4.2	-3.0	-5.8	-4.2	-6.2
Forced vital capacity (FVC), Best measure	4.2	15.3	43.7	1.5	1.3	-1.3	6.6	3.2	5.7
Ever used hormone-replacement therapy (HRT)	4.0	5.0	11.3	0.6	1.5	0.5	2.5	3.4	3.1
Trunk fat-free mass	4.0	23.0	77.6	0.9	1.6	-2.3	8.8	2.6	6.7
Trunk predicted mass	4.0	23.1	78.1	0.9	1.6	-2.3	8.8	2.6	6.7
Diastolic blood pressure, automated reading	3.9	12.1	24.9	-1.1	-2.1	-0.7	-5.0	-4.3	-4.8
Arm fat-free mass (right)	3.8	19.3	66.1	1.0	1.4	-2.0	8.1	2.4	6.1
Lupus	3.7	5.7	7.9	-2.5	-2.3	-2.4	-2.6	-1.4	-2.8
Arm predicted mass (right)	3.7	19.1	64.8	0.7	1.3	-2.2	8.1	2.6	6.0
Arm predicted mass (left)	3.7	18.7	64.5	0.8	1.2	-2.2	8.0	2.3	5.9
Forced vital capacity (FVC)	3.6	13.9	44.5	1.3	0.8	-1.8	6.7	2.5	5.2
Arm fat-free mass (left)	3.6	18.2	61.6	0.8	1.2	-2.2	7.8	2.3	5.9
Whole body water mass	3.5	19.9	68.1	0.6	1.2	-2.5	8.2	2.4	6.1
Mean time to correctly identify matches	3.4	6.5	14.4	2.3	3.1	3.8	0.4	2.1	2.2
Whole body fat-free mass	3.4	19.3	66.7	0.5	1.2	-2.6	8.2	2.2	6.0
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	24.3	0.7	0.8	-1.7	4.9	1.2	3.2
Hand grip strength (left)	3.1	8.1	19.2	2.4	2.2	0.8	4.4	1.6	3.9
Mouth/teeth dental problems: Mouth ulcers	3.0	4.7	6.9	1.9	2.3	2.6	1.9	1.7	2.4
Basal metabolic rate	3.0	16.5	58.2	0.1	0.7	-2.8	7.6	1.9	5.4
Risk taking	2.9	4.3	6.5	1.8	1.7	1.7	2.2	2.3	2.6
Sitting height	2.7	18.9	69.6	-0.5	-0.0	-3.6	8.3	1.6	5.3
Hair/balding pattern: Pattern 4	2.7	6.6	17.0	1.3	2.3	0.5	4.1	2.0	3.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.2	22.4	0.7	0.8	-1.5	4.7	2.2	4.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	8.6	-1.0	-1.4	-0.4	-2.9	-0.7	-2.5
Eye problems/disorders: Cataract	2.5	2.9	4.3	1.7	1.8	2.1	1.6	1.3	1.7
Body Mass Index (BMI) (2010)	2.4	3.3	5.3	1.9	1.8	1.4	1.7	1.7	2.3
Primary Biliary Cirrhosis	2.4	3.5	4.8	2.0	1.6	1.9	1.6	1.7	2.2
Mother’s age at death	2.4	3.0	4.3	1.3	1.4	1.8	1.7	2.1	2.0
High cholesterol (Self-reported)	2.4	4.3	5.6	2.0	2.2	2.0	1.9	1.9	2.4
Reaction Time	2.3	4.4	11.0	2.0	2.5	3.3	0.1	1.6	1.7
Ovarian Cancer	2.3	3.1	5.9	1.4	2.4	2.1	0.9	1.5	1.8
Leg fat-free mass (left)	2.3	12.0	42.8	-0.4	0.2	-3.0	6.5	1.2	4.3
Leg predicted mass (left)	2.3	12.0	43.3	-0.3	0.2	-2.9	6.6	1.2	4.3
Leg fat-free mass (right)	2.3	12.3	42.4	-0.6	0.1	-3.0	6.5	1.5	4.4
Leg predicted mass (right)	2.3	12.0	41.5	-0.6	0.1	-3.0	6.4	1.5	4.3
Wears glasses or contact lenses	2.3	2.7	4.7	-1.1	-1.9	-1.1	-1.6	-1.7	-2.2
Ever smoked	2.3	4.0	9.1	3.0	1.9	2.4	1.3	0.9	1.8
Irritability	2.3	3.9	7.2	-1.8	-2.1	-1.7	-2.7	-1.0	-2.2
Alzheimer’s Disease (in father)	2.2	2.4	4.4	-1.9	-1.9	-0.6	-1.5	-0.3	-2.1
Breast Cancer	2.2	5.2	7.3	2.2	2.5	2.1	2.2	1.9	2.7
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	23.6	0.9	0.6	-1.6	4.9	1.7	3.9
Chronic bronchitis/emphysema (mother)	2.2	2.5	5.9	0.5	1.3	0.6	2.4	1.5	2.1
Illnesses of father: High blood pressure	2.2	2.8	5.2	-1.1	-1.7	-1.4	-2.1	-1.1	-2.3
Alzheimer’s Disease (including proxy)	2.0	2.9	8.5	-2.9	-1.3	-1.8	-1.1	0.3	-1.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	6.2	1.3	1.5	2.5	-1.6	1.0	0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	13.1	1.6	2.1	2.5	-3.6	0.9	-0.5
Medication: Bendroflumethiazide	2.0	3.1	7.0	-2.6	-1.9	-2.1	-1.0	-0.5	-1.5
Eye problems/disorders: Diabetes related eye disease	1.9	2.0	6.5	1.4	0.4	1.0	2.5	0.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.3	11.5	1.7	2.0	2.5	-3.4	0.6	-0.5
Alcohol usually taken with meals	1.9	3.0	7.8	0.7	0.9	0.3	2.8	2.1	2.1
Medication for pain relief, constipation, heartburn	1.9	3.2	6.0	1.7	2.4	1.3	1.6	0.9	2.4
Fasting Glucose	1.8	2.1	4.6	1.5	2.1	1.5	1.0	0.8	1.5
Heel T-Score	1.8	14.6	47.1	3.0	0.8	4.0	-6.9	-1.0	-3.8
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	5.3	-2.0	-1.4	-2.3	0.6	-0.8	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	2.8	1.3	1.3	1.3	1.7	0.8	1.6
Intelligence (Savage-Jansen 2018)	1.7	5.2	10.9	-3.3	-2.8	-2.5	-0.6	-0.7	-2.4
Eye problems/disorders: None of the above	1.7	1.9	3.2	-1.8	-1.4	-1.7	-0.6	-1.3	-1.3
Schizophrenia vs Biploar Disorder	1.6	2.1	5.3	1.9	1.6	2.3	-0.2	0.5	0.6
Verbal and Numeric Reasoning (VNR)	1.6	3.8	6.9	-2.6	-2.5	-2.3	0.0	-0.8	-2.0
Diabetes (father)	1.6	2.0	6.6	1.5	0.7	0.3	2.6	0.8	1.5
Weight	1.6	8.1	29.6	-0.6	-0.2	-2.8	5.4	0.5	3.2
Number of full sisters	1.6	1.9	6.2	-1.0	-1.3	-0.5	-0.7	-2.5	-1.4
Mean Putamen Volume	1.5	1.7	4.5	1.3	1.0	0.6	2.1	0.7	1.4
Sensitivity / hurt feelings	1.5	2.6	6.7	1.4	2.0	2.6	0.5	1.0	1.3
Qualifications: CSEs or equivalent	1.5	2.0	8.8	0.4	-0.3	0.3	-3.0	-0.9	-1.3
Noisy workplace	1.5	1.8	4.8	-0.0	-1.0	-0.7	-1.5	-2.2	-1.5
Tense / ‘highly strung’	1.5	2.5	3.4	-1.8	-1.4	-1.6	-1.6	-1.3	-1.7
Neck or shoulder pain in last month	1.5	2.2	5.6	2.4	0.8	1.9	1.2	0.7	1.2
Long-standing illness, disability or infirmity	1.5	2.3	3.2	-1.3	-1.7	-1.8	-0.5	-1.6	-1.7
Cholesterol lowering medication	1.5	2.2	3.7	1.8	1.6	1.2	0.9	1.4	1.9
Alzheimer’s Disease (in mother)	1.4	1.6	4.7	-2.2	-0.4	-2.0	-0.6	0.5	-0.5
Cardiovascular Disease	1.4	4.6	7.1	-1.6	-2.7	-2.2	-2.1	-1.4	-2.7
Father’s age at death	1.4	1.8	3.6	-1.9	-1.9	-1.7	0.7	0.2	-0.7
Medication: Lansoprazole	1.4	1.6	4.7	-0.5	0.1	-0.9	2.2	1.4	1.4
Migraine (self-reported)	1.4	1.7	6.0	0.2	0.3	1.3	-2.4	-0.8	-1.2
Ever taken oral contraceptive pill	1.4	1.6	4.0	1.4	1.3	2.0	0.7	0.7	0.9
Supplements: Zinc	1.3	1.5	2.9	0.9	1.0	0.6	1.3	1.4	1.7
Blood clot in the leg (DVT)	1.3	1.6	3.9	0.6	1.1	-0.1	2.0	1.1	1.8
Severe depression (siblings)	1.2	1.3	2.2	-1.2	-1.5	-0.9	-1.0	-0.6	-1.4
Hair/balding pattern: Pattern 3	1.2	1.8	4.9	1.1	0.3	0.7	2.2	1.1	1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.8	0.7	0.8	0.7	1.3	1.7	1.4
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	-0.6	-1.0	-0.4	-1.8	-1.0	-1.6
Blood White Count	1.1	8.2	18.5	-2.1	-3.0	-2.0	-3.0	-2.1	-4.3
Medication for hormone replacement therapy	1.1	1.2	3.0	-0.3	0.3	-0.1	1.4	1.7	1.4
Qualifications: College or University degree	1.1	3.4	10.0	-3.2	-1.4	-2.5	1.1	0.2	-0.9
Ever depressed for a whole week	1.1	1.4	3.3	-0.9	-1.3	-1.4	1.8	0.6	0.4
Multivitamins +/- minerals	1.0	1.3	2.6	-1.4	-1.6	-1.4	0.0	0.6	-0.7
Hip circumference	1.0	4.5	12.2	-2.1	-1.8	-3.5	2.4	-1.0	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.1	-1.0	-1.8	-0.8	-0.8	-0.4	-1.4
Impedance of arm (left)	1.0	4.8	11.0	-1.5	-1.8	-0.3	-3.3	-1.3	-3.3
Exposure to tobacco smoke at home	1.0	1.1	1.6	1.0	1.2	0.9	0.9	0.9	1.3
Heart disease (mother)	1.0	1.2	4.5	0.8	-0.1	0.2	2.1	0.6	1.4
Supplements: Vitamin C	1.0	1.2	2.6	0.1	0.9	0.5	1.3	1.6	1.3
Illnesses of siblings: Diabetes	1.0	1.2	2.8	-1.2	-0.6	-0.8	-1.7	-0.9	-1.1
Fractured/broken bones in last 5 years	1.0	1.3	2.8	-1.1	-0.9	-1.7	0.2	-1.4	-0.8
Crohns Disease (2017)	0.9	2.0	3.2	-1.8	-1.8	-1.7	-0.5	-0.9	-1.3
Smoking Status	0.9	2.1	5.7	2.0	1.4	2.4	0.1	0.9	0.5
Alcohol intake versus 10 years previously	0.9	1.4	3.6	1.2	0.7	1.9	1.6	-0.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.1	-0.2	-1.2	-1.2	2.0	-0.0	0.2
High blood pressure (siblings)	0.9	1.2	4.3	-0.3	-0.9	0.2	-2.1	-0.4	-1.4
Overall health rating	0.9	1.9	5.1	1.0	1.2	0.3	2.3	0.4	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.7	0.5	1.2	0.6	1.3	1.1	1.3
Arm fat percentage (left)	0.9	3.5	4.4	-1.9	-2.1	-1.9	-1.1	-1.9	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.7	0.6	1.0	-0.2	1.6	1.0	1.5
Chronotype (morning person)	0.8	1.8	6.7	-0.7	0.3	1.3	-2.6	-0.8	-1.1
Diabetes (mother)	0.8	1.0	1.6	0.1	-1.2	-0.0	-1.3	-1.2	-1.1
Waist circumference	0.8	2.8	8.2	-1.6	-1.6	-2.9	1.8	-0.8	0.2
Hearing difficulty/problems with background noise	0.8	1.2	3.0	1.1	0.5	0.7	1.1	1.7	1.2
Had other major operations	0.8	1.0	4.6	-0.3	0.5	-0.1	2.2	0.0	1.0
Financial difficulties in last 2 years	0.8	1.1	1.8	-1.1	-1.0	-0.6	-1.0	-1.1	-1.3
Impedance of arm (right)	0.8	4.0	10.4	-1.1	-1.3	-0.1	-3.2	-1.2	-3.0
Lung cancer (father)	0.8	0.9	1.8	0.9	1.4	1.3	-0.2	0.9	0.8
Birth weight of first child	0.8	1.5	5.1	1.2	0.4	0.1	2.3	-0.5	1.5
Peak expiratory flow (PEF)	0.8	1.8	4.0	-1.1	-0.5	-2.0	1.8	0.7	1.2
Medication: Atorvastatin	0.8	0.9	1.8	1.1	1.3	1.1	0.6	0.4	1.0
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.8	1.4	1.6	1.7	1.4	0.8	1.5
Bipolar Disorder (2018)	0.7	1.2	3.2	-1.1	-1.4	-1.8	0.3	-0.0	-0.6
Irritable Bowel Disease (IBD)	0.7	1.6	2.9	-1.7	-1.4	-1.2	-1.2	-0.5	-1.2
Bipolar Disorder (2011)	0.7	0.7	2.6	-0.6	-0.2	-0.8	0.6	1.6	0.5
Coronary Artery Disease (CAD)	0.7	0.8	1.3	0.9	1.1	1.2	-0.6	-1.0	-0.0
Relative age voice broke	0.7	1.1	4.3	-0.4	-0.1	0.8	-2.1	0.4	-1.3
High blood pressure	0.7	1.9	3.0	-1.4	-1.4	-1.2	-1.7	-0.8	-1.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	-0.7	0.8	-0.3	1.1	1.1	1.1
Fluid intelligence score	0.7	1.4	3.5	-1.9	-1.3	-1.5	0.8	0.3	-0.6
Illnesses of siblings	0.7	1.0	4.2	0.0	0.5	-0.4	2.1	0.6	1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	2.4	-0.5	-1.1	-1.6	-0.3	-1.5	-0.7
Length of working week for main job	0.7	0.7	3.1	-0.4	-0.5	-1.8	0.6	-0.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	3.0	-0.9	-1.3	-1.7	0.7	0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.1	-0.8	-1.4	-1.2	0.3	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.7	-1.1	-1.3	-1.2	-0.4	-0.7	-1.2
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-1.2	-1.1	-1.3	-0.3	-0.4	-0.6
Number of children fathered	0.7	0.8	2.0	-0.8	-1.1	-1.4	-0.6	-0.5	-0.4
Shortness of breath walking on level ground	0.7	0.9	3.4	0.1	-0.2	-0.3	-0.9	-1.9	-1.0
Medication: Ibuprofen	0.7	0.8	2.0	-0.9	-1.4	-0.6	-0.7	-0.0	-1.2
Smoking status: Previous	0.7	1.1	2.7	1.6	0.7	1.4	0.8	-0.5	0.5
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	1.1	1.2	1.0	0.5	0.1	1.2
Number of operations (self-reported)	0.7	1.0	1.9	-1.4	-0.7	-1.0	1.1	-1.1	-0.1
Myopia	0.7	1.0	2.6	-0.4	0.4	-0.5	1.4	1.6	1.1
Pack years of smoking	0.7	1.0	2.8	1.5	0.8	1.7	-0.3	-0.6	0.0
Schizophrenia (2018)	0.6	1.3	3.4	-0.3	0.6	-0.5	1.2	1.8	1.5
Prostate Cancer	0.6	0.9	2.0	-1.4	-0.3	-1.1	-0.3	1.4	0.3
Schizophrenia (2014)	0.6	1.4	3.4	0.0	0.1	-0.9	1.5	1.8	1.3
Lung FVC	0.6	3.0	7.7	1.4	1.3	0.5	1.9	1.7	2.8
Number of treatments/medications taken	0.6	1.0	2.2	-0.9	-1.0	-0.3	-1.1	-1.0	-1.5
Pack years adult smoking proportion	0.6	1.0	2.9	1.5	0.7	1.7	-0.1	-0.6	0.0
Taking other prescription medications	0.6	0.9	1.6	-0.9	-0.8	-1.0	-0.8	-0.9	-1.3
High blood pressure (mother)	0.6	0.8	2.2	1.5	0.9	1.3	-0.2	0.1	-0.1
Past tobacco smoking	0.6	1.2	3.4	-1.8	-0.9	-1.3	-0.7	0.0	-0.8
Hair/balding pattern: Pattern 2	0.6	0.8	3.7	-0.3	0.2	0.2	-1.9	-0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	0.6	0.5	1.4	-1.0	1.1	0.2
Arm fat percentage (right)	0.6	2.5	3.2	-1.4	-1.7	-1.6	-1.0	-1.7	-1.8
Falls in the last year	0.6	0.8	1.8	-1.3	-1.1	-1.2	-0.1	-0.3	-0.5
Prospective memory result	0.6	0.8	2.0	-0.7	-1.4	-0.9	-0.1	-0.5	-1.0
Medication: Paracetamol	0.6	1.0	2.5	-0.6	-0.9	0.5	-1.6	-0.0	-1.4
Number of full brothers	0.6	0.8	2.0	1.4	0.9	1.1	-0.2	-0.7	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.8	-1.4	-0.7	-1.3	0.5	-0.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	0.9	1.2	1.1	-0.5	0.3	0.6
Medication: Blood pressure	0.6	1.1	2.2	-1.2	-1.0	-0.5	-1.2	-0.8	-1.5
Suffer from ‘nerves’	0.6	1.0	3.8	-0.5	-0.4	0.1	-1.9	-0.4	-1.3
Age at last live birth	0.6	0.8	2.1	-1.5	-0.6	-0.8	1.1	0.8	-0.1
Hypertension (Self-reported)	0.6	1.7	2.5	-1.2	-1.3	-1.1	-1.5	-0.9	-1.6
Average weekly red wine intake	0.6	0.8	2.3	1.5	0.6	0.8	0.5	0.8	0.8
Medication for cholesterol	0.6	0.8	1.9	-0.8	-0.4	-0.2	-0.8	-1.3	-1.4
Mineral and other dietary supplements	0.6	0.7	2.9	0.6	0.6	-0.4	1.7	0.0	0.8
Breast cancer (self-reported)	0.6	0.8	2.3	-1.5	-0.5	-1.2	0.1	-0.8	-0.1
Osteoporosis (self-reported)	0.6	0.7	1.7	-0.6	-0.5	-0.9	1.0	1.3	0.4
Medication: Gliclazide	0.6	0.7	1.6	1.1	1.2	1.0	0.2	-0.1	0.7
Arm fat mass (left)	0.6	2.4	6.3	-1.4	-1.4	-2.5	1.9	-0.9	0.3
Miserableness	0.6	1.1	2.4	-1.5	-1.4	-1.1	-0.2	0.7	-0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.7	0.0	-0.3	1.0	-1.6	-0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	-1.2	-0.4	-0.4	-1.3	0.1	-1.0
Pain experienced in last month	0.6	1.0	2.6	-1.6	-0.4	-1.6	0.9	-0.1	0.1
Bipolar Disorder or Schizophrenia	0.5	1.2	2.3	-0.9	-0.5	-1.5	1.2	1.4	0.7
Depression (Nagel 2018)	0.5	0.8	2.0	-0.1	0.6	0.1	1.4	1.1	1.1
Age at First Birth	0.5	0.8	3.8	0.3	0.3	-0.3	0.1	1.9	0.7
HbA1C	0.5	0.5	1.5	0.8	0.1	0.7	1.2	-0.4	0.6
Ulcerative Colitis	0.5	0.7	1.7	0.3	0.7	1.0	-0.5	1.3	0.7
Lung FEV1/FVC ratio	0.5	2.6	8.6	-0.6	0.0	0.6	-2.9	-1.5	-2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	-0.8	-0.6	-1.4	0.8	-0.7	0.1
Vitamin and mineral supplements	0.5	0.7	1.4	0.9	0.9	1.2	-1.0	-0.6	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.2	-1.5	-0.5	-1.1	-0.1	-0.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	0.7	0.9	1.3	-0.0	0.3	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.4	-0.5	-0.5	-1.2	1.1	-0.8	0.0
Supplements: Glucosamine	0.5	0.7	2.1	-0.7	-0.9	-0.5	-1.4	0.4	-0.7
Trunk fat mass	0.5	2.2	8.0	-0.6	-0.3	-1.7	2.8	-0.1	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	-0.4	-0.9	-1.0	1.2	0.1	0.2
Worrier / anxious feelings	0.5	1.0	2.7	-1.4	-1.0	-1.6	0.6	0.3	-0.2
Number of live births	0.5	0.7	1.3	0.5	0.9	0.9	1.1	0.2	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	-1.3	-1.2	-1.6	0.2	0.2	-1.2
Age at first live birth	0.5	0.9	4.0	-1.0	-0.2	-0.6	0.0	2.0	0.1
Whole body fat mass	0.5	1.9	6.8	-0.6	-0.4	-1.7	2.6	-0.2	1.1
Pulse rate, automated reading	0.5	1.5	3.5	1.3	0.9	1.9	1.0	1.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-0.8	0.2	-0.4	-1.4	-0.4	-0.6
Ever had bowel cancer screening	0.5	0.6	1.0	-0.8	-1.0	-1.0	0.6	-0.8	-0.4
Qualifications: nursing, teaching	0.5	0.8	2.0	-1.0	-0.8	-1.4	0.7	-0.6	-0.5
Osteoarthritis (self-reported)	0.5	0.7	2.6	0.1	0.2	0.6	1.6	0.3	0.9
Number of self-reported non-cancer illnesses	0.5	1.0	2.8	-1.7	-0.9	-1.2	-0.5	0.1	-0.6
Alcohol drinker status: Never	0.5	0.6	1.5	-0.3	-0.6	-0.1	-1.2	-0.7	-1.0
Unable to work because of sickness or disability	0.5	0.6	2.9	-0.3	-0.0	-0.4	1.7	-0.0	0.9
LDL Cholesterol	0.4	0.6	1.2	0.8	0.6	1.0	-0.6	-1.1	-0.2
Neuroticism (2016)	0.4	0.5	1.2	-0.4	0.3	0.6	-1.0	1.1	-0.5
Rheumatoid Arthritis	0.4	0.5	1.6	1.3	0.1	0.4	-1.0	-0.4	-0.2
Blood Eosinophil Count	0.4	3.4	7.5	-2.1	-2.4	-2.7	0.9	-0.9	-1.1
Blood Platelet Count	0.4	5.0	18.3	-1.2	-0.8	1.0	-4.3	0.9	-2.8
Allergy or Eczema	0.4	1.1	3.3	-1.8	-1.2	-0.9	-0.4	0.2	-0.9
Respiratory disease	0.4	0.9	3.3	-0.6	0.5	-0.3	1.8	0.6	1.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-1.1	-0.2	-0.6	1.0	0.6	0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-0.3	-0.0	-0.3	1.4	1.1	0.7
Relative age of first facial hair	0.4	0.8	2.5	0.1	0.5	1.1	-1.6	0.6	-0.5
Current tobacco smoking	0.4	0.6	2.0	0.2	0.2	0.8	-1.4	0.6	-0.6
Stomach or abdominal pain in last month	0.4	0.5	1.1	-0.7	-0.9	-0.7	-0.3	1.1	-0.3
Medication: Levothyroxine sodium	0.4	0.6	1.3	-0.8	-0.7	-1.1	-1.0	-0.4	-0.6
Number of incorrect matches in round	0.4	0.7	1.6	0.4	1.0	0.5	1.0	0.6	1.3
Illnesses of mother	0.4	0.5	1.2	-0.5	-0.8	-0.5	-0.2	-1.1	-0.6
Arm fat mass (right)	0.4	1.8	4.5	-1.1	-1.0	-2.1	1.8	-0.5	0.6
Breastfed as a baby	0.4	0.5	1.2	0.6	-0.1	0.4	-1.0	-1.1	-0.5
Medication: Amlodipine	0.4	0.5	1.8	-0.4	-0.2	0.4	-1.4	-0.2	-1.0
Health satisfaction	0.4	0.5	1.3	-0.7	-0.4	-0.8	1.2	-0.5	0.6
Leg fat mass (right)	0.4	1.5	5.4	-0.4	-0.2	-1.4	2.3	-0.5	1.0
Loneliness, isolation	0.4	0.5	2.5	-0.1	-0.7	-0.4	1.6	0.0	0.1
Friendships satisfaction	0.4	0.5	1.9	-0.3	0.6	0.5	0.4	1.4	0.7
Medication: Paracetamol	0.4	0.6	1.9	-0.3	-0.1	0.9	-1.4	0.3	-0.8
Supplements: Calcium	0.4	0.4	1.0	-1.0	-0.5	-0.2	-0.7	0.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.3	-0.8	-0.9	1.1	0.1	0.3
Alcohol drinker status: Previous	0.4	0.5	1.3	0.7	0.6	0.9	-1.1	-0.2	-0.3
Impedance of whole body	0.4	2.0	6.3	-0.3	-0.7	0.7	-2.5	-0.5	-2.2
Leg fat mass (left)	0.4	1.7	5.5	-0.7	-0.5	-1.7	2.3	-0.5	1.0
Ulcerative Colitis (UC)	0.3	0.5	2.3	-0.7	-0.2	-0.1	-1.5	0.1	-0.6
HDL Cholesterol	0.3	0.6	1.1	0.7	0.7	1.1	-0.2	1.1	0.4
Blood Red Count	0.3	3.2	7.3	-2.2	-1.1	-2.7	0.3	-2.0	-1.2
Age when periods started (menarche)	0.3	0.8	1.8	-0.3	0.4	0.3	-1.3	-1.2	-1.1
Body mass index (BMI)	0.3	1.3	2.7	-1.2	-1.1	-1.6	0.3	-1.4	-0.6
Qualifications: None of the above	0.3	0.6	1.5	1.0	0.6	0.8	0.5	0.3	1.2
Mouth/teeth dental problems	0.3	0.5	1.6	-0.1	0.7	0.7	-1.3	0.1	-0.5
Heart attack	0.3	0.4	0.8	-0.2	-0.7	-0.8	0.9	0.1	0.3
Medication: Ramipril	0.3	0.4	1.1	1.1	0.8	0.7	0.1	-0.5	0.3
Happiness	0.3	0.3	0.8	-0.1	-0.7	-0.6	0.9	0.5	0.3
Pulse wave Arterial Stiffness index	0.3	0.3	1.3	-0.1	0.5	0.1	1.1	-0.5	0.5
Loud music exposure frequency	0.3	0.3	0.8	0.9	0.1	0.9	0.2	0.4	-0.0
Headache pain in last month	0.3	0.6	2.5	0.3	0.3	1.6	-0.2	0.9	-0.2
Comparative body size at age 10	0.3	0.9	1.9	-1.4	-0.9	-1.1	-1.0	-0.4	-0.7
Worry too long after embarrassment	0.3	0.5	1.3	-0.1	0.9	1.2	0.5	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.8	-0.9	-0.7	-0.3	-0.0	-0.3
Angina (self-reported)	0.3	0.4	1.0	-0.3	-0.7	-1.0	0.1	-0.7	-0.3
Medication: Omeprazole	0.3	0.3	1.0	-0.6	-0.2	-0.0	-1.0	0.5	-0.6
Family relationship satisfaction	0.3	0.4	0.9	1.0	0.6	0.7	0.6	-0.3	0.5
Leg pain on walking	0.3	0.3	1.3	-0.2	-0.2	-0.2	1.1	-0.3	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	-0.0	0.8	0.9	-0.2	0.8	0.4
Illnesses of father: Heart disease	0.3	0.4	1.1	-0.3	-0.7	-0.5	0.7	1.0	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	0.6	1.0	0.4	0.4	0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.6	-0.5	-0.8	-0.7	-0.3	-0.5
Medication: Aspirin	0.3	0.4	1.6	0.6	0.4	0.3	1.3	-0.2	0.5
Smoking status: Current	0.3	0.5	0.9	0.6	0.6	0.9	-0.9	0.7	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.2	0.5	-0.7	0.9	0.1	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.9	-0.8	-0.3	-0.3	-0.0	-0.9
Leg fat percentage (left)	0.3	0.9	1.9	-0.9	-0.8	-1.0	-0.4	-1.4	-1.0
Average weekly beer plus cider intake	0.3	0.4	1.0	0.4	-0.7	-1.0	-0.7	-0.6	-0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.5	-0.5	0.1	0.6	1.1	0.3
BMI	0.2	0.9	2.2	-0.5	-1.2	-1.5	1.0	-0.9	-0.2
Waist Hip Ratio (WHR)	0.2	0.8	1.6	-0.1	-1.2	-1.1	1.3	0.7	0.2
Hypothyroidism (self reported)	0.2	0.4	1.5	-0.3	-0.6	-1.2	-0.2	-0.2	0.2
Tanning	0.2	2.2	4.5	1.4	1.2	1.2	1.8	0.9	2.1
Average weekly spirits intake	0.2	0.3	0.5	-0.6	0.0	-0.4	-0.5	-0.7	-0.5
Angina	0.2	0.3	0.9	-0.2	-0.7	-0.9	0.3	-0.5	-0.2
Medication: Metformin	0.2	0.3	0.8	-0.2	0.8	-0.1	0.4	-0.9	0.2
Impedance of leg (right)	0.2	0.9	2.4	1.1	0.6	1.6	-1.1	0.3	-0.7
Trunk fat percentage	0.2	0.8	1.7	-0.9	-0.9	-1.3	0.5	-0.8	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.7	-0.7	-0.4	-0.3	-0.4	-0.8
Average weekly fortified wine intake	0.2	0.2	0.3	-0.5	-0.4	-0.6	0.1	-0.5	-0.4
Fed-up feelings	0.2	0.3	1.0	-0.1	0.5	0.7	0.3	1.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.2	0.4	-0.4	0.4	0.8	0.5
Impedance of leg (left)	0.2	0.9	2.6	1.0	0.6	1.6	-0.9	0.8	-0.4
Nervous feelings	0.2	0.5	0.9	-0.6	-0.7	0.1	-0.6	0.7	-1.0
Had menopause	0.2	0.3	0.4	0.4	0.6	0.6	0.6	0.3	0.7
Pain all over the body in last month	0.2	0.2	0.4	-0.7	-0.4	-0.6	-0.2	0.4	0.0
Diabetes (self-reported)	0.2	0.2	1.2	-0.3	0.3	-0.1	-0.0	-1.1	-0.1
Neuroticism score	0.2	0.3	1.2	-0.7	-0.0	0.4	-0.2	1.1	-0.1
Time employed in main current job	0.2	0.2	0.5	-0.4	-0.7	-0.6	0.0	0.1	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.4	-0.5	-0.8	0.9	0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.9	-0.3	-0.1	-0.1	-0.5	-0.4
Medication: Cholesterol lowering	0.2	0.2	1.1	0.2	0.1	0.4	1.1	0.1	0.3
Pulse wave reflection index	0.2	0.3	0.9	-0.3	0.5	0.4	-0.4	-1.0	-0.0
Gout (self-reported)	0.2	0.2	0.5	0.2	-0.3	-0.4	0.5	0.7	0.4
Birth weight	0.2	0.4	0.8	-0.4	-0.7	-0.9	0.9	0.5	0.6
Body fat percentage	0.2	0.8	1.3	-0.8	-0.9	-1.1	-0.1	-1.1	-0.9
Leg fat percentage (right)	0.2	0.8	2.4	-0.5	-0.7	-0.8	-0.4	-1.5	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.6	-0.5	-0.1	-0.4	0.9	-0.4
Pulse wave peak to peak time	0.2	0.2	1.2	0.3	-0.2	-0.0	-0.2	1.1	0.3
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.1	0.8	0.3	-0.3	-0.6	0.1
Alcohol intake frequency.	0.2	0.6	1.1	0.2	-0.4	0.4	-1.0	-1.0	-0.9
Chest pain or discomfort	0.2	0.3	0.7	0.1	-0.6	-0.8	0.7	-0.1	0.1
Knee pain experienced in last month	0.2	0.2	0.6	-0.8	-0.6	-0.6	-0.2	-0.2	-0.4
Mood swings	0.2	0.4	0.9	-0.7	-0.4	0.4	-1.0	-0.3	-0.7
Back pain experienced in last month	0.2	0.3	1.5	1.2	-0.1	0.5	-0.4	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.1	-0.1	-0.6	1.0	0.1	0.8
Guilty feelings	0.2	0.3	0.7	-0.3	0.3	0.1	0.5	0.9	0.7
Age started oral contraceptive pill	0.2	0.3	1.2	-0.6	0.2	-0.1	-1.1	0.1	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.4	-0.6	-0.9	-0.4	0.4	-0.3
Heart disease (siblings)	0.2	0.3	1.1	0.3	0.0	0.0	1.0	-0.5	0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.8	-0.4	-0.3	0.1	0.3	0.9	0.0
Worry (Nagel 2018)	0.1	0.2	0.4	-0.3	-0.4	0.0	-0.5	0.4	-0.6
Major Depression (MDD)	0.1	0.2	0.5	-0.3	0.3	0.7	-0.1	0.5	0.2
Crohns Disease (2012)	0.1	0.2	0.9	-1.0	-0.4	-0.5	0.0	-0.3	-0.0
Triglycerides	0.1	0.2	0.5	0.6	0.3	0.5	-0.0	-0.7	-0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.5	0.2	-0.3	0.5	-0.1	0.2
Neuroticism	0.1	0.2	0.7	0.0	0.3	0.8	-0.5	0.6	-0.1
Medication: Co-codamol	0.1	0.1	0.4	-0.5	-0.0	-0.3	0.0	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.3	-0.3	0.4	0.2	0.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.7	-0.2	-0.3	0.0	0.9	0.0	0.1
Allergy	0.1	0.2	0.4	0.2	-0.4	-0.5	-0.6	-0.3	-0.3
Medication: Simvastatin	0.1	0.2	0.4	0.6	0.3	0.5	0.4	0.5	0.4
Pulse rate	0.1	0.2	0.6	0.2	0.4	0.8	-0.1	0.4	-0.0
Asthma	0.1	0.2	0.8	-0.9	-0.2	-0.3	0.3	0.1	-0.2
Depression (self-reported)	0.1	0.1	0.3	-0.3	-0.5	0.0	0.2	0.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.4	0.4	-0.2	0.5	0.3	0.8
Glaucoma (self-reported)	0.1	0.1	0.6	-0.2	0.0	-0.7	-0.0	0.4	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.5	-0.3	-0.0	0.1	-0.5	-0.1
Medication: Allopurinol	0.1	0.2	0.7	0.1	-0.3	-0.2	-0.2	0.8	-0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.2	-0.4	-0.5	-0.5	-0.1	-0.5	-0.3
Had major operations	0.1	0.1	0.3	-0.5	0.2	0.2	-0.4	-0.4	-0.3
Medication: Aspirin	0.1	0.1	0.5	0.2	-0.0	0.0	0.7	-0.3	0.0
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.3	0.4	-0.3	0.8	-0.3	0.5
Commuting to job workplace: Walk	0.1	0.2	0.4	0.5	0.2	0.6	-0.1	0.3	0.2
Asthma (self-reported)	0.1	0.2	0.7	-0.8	0.0	-0.2	0.7	0.3	0.1
Hearing aid user	0.1	0.1	0.4	0.4	0.1	0.5	0.2	0.6	0.1
Financial situation satisfaction	0.1	0.1	0.6	-0.0	0.0	0.0	0.7	-0.2	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	0.1	0.1	0.5	0.3	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.0	-0.1	-0.6	-0.1	0.3	-0.0
Medication: Blood pressure	0.1	0.2	0.4	-0.1	-0.6	-0.6	-0.3	-0.4	-0.2
Medication: Lisinopril	0.1	0.1	0.4	-0.4	-0.3	-0.1	-0.3	0.7	-0.4
Hair Pigment	0.0	0.1	0.5	-0.3	-0.1	-0.7	-0.2	-0.4	-0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	0.1	0.3
Maternal smoking around birth	0.0	0.0	0.1	-0.3	-0.1	0.2	0.3	-0.0	0.0
Medication: Atenolol	0.0	0.1	0.2	0.2	0.2	-0.2	-0.4	0.0	-0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.0	0.1	-0.5	-0.3	0.0	0.4

Hub : Genes

SLFNL1

Models

Trait associations