TWAS hub - CTPS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0476	0.0252	0.0011	0.036	0.033	0.010	NA	0.026	0.00005	0.0001	0.0240	NA	0.00051
2	TCGA	Lung Adenocarcinoma	0.0579	0.0315	0.0024	0.002	0.015	0.018	NA	0.007	0.15000	0.0058	0.0033	NA	0.05100
3	TCGA	Soft Tissue Sarcoma	0.0590	0.0300	0.0055	-0.002	0.000	-0.004	NA	-0.005	0.46000	0.3000	0.6700	NA	0.91000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative height size at age 10	6.0	32.9	48.4	7.0	-5.1	5.0
Forced vital capacity (FVC), Best measure	5.5	20.0	28.8	4.7	-5.4	2.9
Forced vital capacity (FVC)	5.4	20.8	29.2	5.4	-5.0	2.9
Sitting height	4.6	32.7	50.1	7.1	-4.8	5.0
Trunk fat-free mass	4.5	25.6	32.0	5.7	-5.3	4.1
Trunk predicted mass	4.5	25.6	32.1	5.7	-5.3	4.0
Type 2 Diabetes (T2D) (2012)	4.3	4.9	7.4	-2.7	-0.3	-2.7
Arm fat-free mass (left)	4.1	20.9	25.1	5.0	-4.7	4.0
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.7	14.9	3.9	-3.8	2.9
Commuting to job workplace: Public transport	4.0	4.8	6.9	1.4	2.4	2.6
Standing height	3.9	38.2	55.4	7.4	-5.8	5.1
Mean time to correctly identify matches	3.9	7.5	16.6	-2.4	0.1	-4.1
Whole body fat-free mass	3.9	22.6	28.9	5.4	-4.5	4.3
Whole body water mass	3.9	22.4	28.4	5.3	-4.5	4.3
Arm predicted mass (left)	3.9	20.1	23.3	4.8	-4.6	4.0
Arm predicted mass (right)	3.8	19.6	24.1	4.9	-4.4	3.9
Basal metabolic rate	3.8	21.2	27.8	5.3	-4.0	4.5
Forced expiratory volume in 1-second (FEV1)	3.7	12.4	16.2	4.0	-3.8	2.6
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.7	8.7	2.7	-2.7	3.0
Arm fat-free mass (right)	3.6	18.4	21.7	4.7	-4.5	3.7
Leg fat-free mass (right)	3.6	19.0	27.0	5.2	-3.0	4.6
Diverticular disease/diverticulitis (self-reported)	3.5	4.1	5.8	2.4	1.1	2.4
Leg predicted mass (right)	3.5	18.9	26.3	5.1	-3.0	4.6
Leg fat-free mass (left)	3.4	18.1	24.5	5.0	-3.2	4.5
Sensitivity / hurt feelings	3.3	5.7	8.0	-2.4	-2.8	-1.9
Leg predicted mass (left)	3.3	17.7	23.8	4.9	-3.2	4.3
Reaction Time	3.2	6.1	16.0	-1.5	0.1	-4.0
Alzheimer’s Disease (in mother)	3.1	3.7	5.5	0.8	2.3	2.2
Height	3.0	58.5	77.3	8.8	-8.0	5.8
Alzheimer’s Disease (including proxy)	2.9	4.2	7.9	-0.5	2.8	2.1
Relative age voice broke	2.9	4.4	6.9	-2.6	2.4	-0.7
Commuting to job workplace: Car/motor vehicle	2.7	3.0	5.1	-1.5	-1.4	-2.3
Weight	2.6	12.6	16.9	4.1	-2.2	4.0
Schizophrenia vs Biploar Disorder	2.5	3.3	6.1	-2.5	-1.0	-1.7
Verbal and Numeric Reasoning (VNR)	2.3	5.6	9.7	0.5	3.1	2.6
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	8.5	-2.5	0.4	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	9.1	-2.4	0.3	-3.0
Hip circumference	2.2	9.3	20.5	2.7	-0.6	4.5
Father’s age at death	2.2	2.9	6.5	1.4	-0.3	2.5
Peak expiratory flow (PEF)	2.2	5.2	8.6	2.6	-0.5	2.9
Qualifications: College or University degree	2.2	6.8	10.4	0.7	3.1	3.2
Ever taken oral contraceptive pill	2.2	2.4	5.6	-1.2	-0.6	-2.4
Ever smoked	2.2	3.8	7.4	-1.3	-1.5	-2.7
Illnesses of father: High blood pressure	2.1	2.6	6.0	-0.7	2.5	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	3.4	-1.7	-1.8	-0.4
Heart attack/myocardial infarction (self-reported)	2.0	2.6	5.4	2.3	-1.5	0.3
Neuroticism (2016)	1.9	2.7	8.0	-2.8	0.3	0.1
Heel T-Score	1.9	15.5	29.7	-3.9	1.2	-5.5
Smoking Status	1.9	4.7	6.5	-2.4	-1.3	-2.6
Heart attack	1.9	2.4	4.9	2.2	-1.5	0.2
Headache pain in last month	1.9	3.3	9.4	-3.1	0.6	-0.3
Migraine (self-reported)	1.9	2.4	5.3	-2.3	1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	5.3	-2.3	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	7.8	-0.8	1.9	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	6.4	-0.4	2.5	0.3
Eye problems/disorders: Cataract	1.8	2.1	3.0	-1.7	0.8	-1.6
Ever depressed for a whole week	1.8	2.2	4.3	1.4	-0.6	2.1
Alzheimer’s Disease (in father)	1.7	1.8	2.4	-1.5	1.5	0.9
Ovarian Cancer	1.7	2.3	3.6	-1.9	-1.0	-1.5
Prostate Cancer	1.7	2.3	4.5	1.3	2.1	0.9
Multivitamins +/- minerals	1.7	2.2	4.5	0.8	1.2	2.1
Alcohol intake versus 10 years previously	1.7	2.5	3.3	-0.9	-1.8	-1.8
Length of working week for main job	1.7	1.9	4.0	2.0	-0.4	1.2
Medication: Bendroflumethiazide	1.7	2.5	4.4	0.7	2.1	1.6
Intelligence (Savage-Jansen 2018)	1.6	4.8	7.8	0.5	2.8	2.5
Lupus	1.6	2.4	5.4	0.9	1.1	2.3
Relative age of first facial hair	1.6	3.3	6.8	-2.6	1.5	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	6.0	0.5	1.0	2.5
Age at first live birth	1.6	2.9	4.1	-2.0	1.4	1.6
Age at last live birth	1.6	2.4	3.8	-1.7	0.8	1.9
Bipolar Disorder or Schizophrenia	1.5	3.7	8.8	3.0	0.5	1.5
Waist circumference	1.5	5.6	12.5	2.1	-0.2	3.5
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	3.0	-1.3	-1.5	-1.7
Bipolar Disorder (2018)	1.4	2.1	2.9	1.7	0.8	1.7
Blood Platelet Count	1.4	16.0	36.2	-2.8	6.0	-1.9
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	2.8	1.7	-0.8	1.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.1	0.1	-2.0	-0.6
Hand grip strength (right)	1.4	3.8	9.7	1.3	-3.1	0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-0.3	-1.0	2.1
Worry too long after embarrassment	1.4	2.3	6.0	-2.4	-0.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.6	1.6	1.2	1.1
Number of children fathered	1.4	1.6	3.3	1.2	-0.3	1.8
Smoking status: Previous	1.4	2.0	2.2	-1.5	-1.4	-1.4
High cholesterol (Self-reported)	1.4	2.4	4.4	-2.1	-0.8	-1.4
Pack years of smoking	1.4	2.1	5.4	-1.0	-0.0	-2.3
Crohns Disease (2017)	1.3	2.8	7.2	0.7	0.8	2.7
LDL Cholesterol	1.3	2.0	3.3	-1.5	-1.8	-0.6
Vitamin and mineral supplements	1.3	1.8	4.1	-0.7	-0.9	-2.0
Pack years adult smoking proportion	1.3	1.9	5.3	-0.7	-0.2	-2.3
Pain all over the body in last month	1.3	1.4	3.7	1.9	0.6	-0.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.1	0.3	0.1	-2.3
Number of live births	1.3	1.8	2.8	-1.7	-1.6	0.1
Loud music exposure frequency	1.3	1.4	3.5	-1.9	-0.6	-0.4
Medication: Ibuprofen	1.3	1.5	2.0	-0.9	1.4	1.3
Fractured/broken bones in last 5 years	1.3	1.7	2.9	1.5	-0.2	1.7
Bipolar Disorder (2011)	1.2	1.2	2.6	1.6	0.3	0.9
Ever had hysterectomy (womb removed)	1.2	1.4	4.1	-0.3	-2.0	0.1
Serious illness, injury or assault to yourself	1.2	1.5	2.6	1.6	-0.3	1.3
Birth weight of first child	1.2	2.1	5.8	0.7	-2.4	-0.2
Neck or shoulder pain in last month	1.2	1.8	2.2	-0.9	-1.5	-1.5
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.5	-1.9	0.4	1.0
Body Mass Index (BMI) (2010)	1.1	1.5	4.1	-0.4	-2.0	-0.5
Coronary Artery Disease (CAD)	1.1	1.4	2.1	-1.4	0.0	-1.5
Fasting Glucose	1.1	1.3	3.5	-0.6	0.3	-1.9
Primary Biliary Cirrhosis	1.1	1.6	2.2	-0.7	-1.4	-1.5
Schizophrenia (2014)	1.1	2.4	5.6	2.4	-0.2	1.2
Age when periods started (menarche)	1.1	2.7	6.4	-2.5	1.3	0.3
Fluid intelligence score	1.1	2.3	4.4	0.1	1.6	2.1
Medication: Lansoprazole	1.1	1.3	3.1	0.8	-0.3	1.8
Lung cancer (father)	1.1	1.2	3.7	-0.1	0.0	-1.9
Tense / ‘highly strung’	1.1	1.9	3.5	0.8	1.9	1.2
Emphysema/chronic bronchitis	1.1	1.3	2.0	1.2	-0.6	-1.4
Angina (self-reported)	1.1	1.4	1.6	1.1	-1.2	1.3
Pulse rate, automated reading	1.1	3.6	9.4	-3.1	-0.1	-1.2
Long-standing illness, disability or infirmity	1.1	1.7	4.6	0.3	0.7	2.1
Arm fat mass (left)	1.1	4.6	8.4	2.3	0.1	2.9
Medication: Atorvastatin	1.1	1.4	2.7	-1.0	-1.6	-0.6
Diastolic blood pressure, automated reading	1.1	3.3	6.5	-2.5	1.9	-0.1
Pain experienced in last month	1.1	1.8	2.5	1.0	1.6	1.3
Schizophrenia (2018)	1.0	2.0	5.9	2.4	-0.1	0.5
Chronotype (morning person)	1.0	2.2	5.3	-2.3	1.0	-0.7
Worrier / anxious feelings	1.0	1.9	5.5	0.5	-0.2	2.3
Medication for pain relief, constipation, heartburn	1.0	1.8	4.8	0.2	-0.7	-2.2
Chest pain or discomfort	1.0	1.5	3.3	1.8	-0.7	0.8
Breast cancer (self-reported)	1.0	1.1	2.7	1.6	0.3	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.6	-1.2	0.9	-1.3
Average weekly beer plus cider intake	1.0	1.4	3.2	1.8	-1.0	0.3
Alcohol drinker status: Previous	1.0	1.1	3.0	-0.3	-0.5	-1.7
Lung FVC	0.9	4.6	9.6	2.0	-3.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.9	1.2	-1.4	0.0
Angina	0.9	1.2	1.5	1.0	-1.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	1.6	1.2	-0.2	1.2
Mouth/teeth dental problems: Dentures	0.9	1.6	4.0	2.0	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.7	-0.7	1.3	1.1
Arm fat mass (right)	0.9	3.5	6.5	2.0	0.1	2.5
Glaucoma (self-reported)	0.9	1.1	2.0	1.4	0.7	0.8
Heart disease (mother)	0.9	1.0	1.6	1.2	-1.2	0.2
Illnesses of siblings: Diabetes	0.9	1.1	3.1	1.8	0.4	0.3
Medication: Gliclazide	0.9	1.1	1.3	-1.1	-1.1	-0.8
Average weekly champagne plus white wine intake	0.9	1.3	2.5	0.8	-1.6	0.8
Miserableness	0.9	1.6	2.2	1.0	1.3	1.5
Systolic Blood Pressure	0.8	3.8	8.9	-0.3	3.0	1.5
Cardiovascular Disease	0.8	2.7	4.1	0.7	2.0	1.9
Hypothyroidism (self reported)	0.8	1.8	4.5	2.1	-0.4	0.7
Lung FEV1/FVC ratio	0.8	4.0	11.8	-3.4	0.5	-0.3
Medication for hormone replacement therapy	0.8	0.9	2.5	1.6	0.2	0.2
Severe depression (siblings)	0.8	0.9	2.8	-0.0	0.1	1.7
Impedance of leg (right)	0.8	3.7	5.9	-2.4	1.1	-2.0
High blood pressure (mother)	0.8	1.2	2.5	-1.6	-0.9	-0.4
Number of incorrect matches in round	0.8	1.3	1.6	1.3	-0.9	-1.1
Past tobacco smoking	0.8	1.5	2.4	0.7	1.3	1.5
Impedance of arm (left)	0.8	3.9	10.3	-1.1	3.2	-0.4
Birth weight	0.8	1.7	3.5	0.2	-1.2	1.9
Exposure to tobacco smoke outside home	0.8	1.1	1.7	1.2	-0.1	1.3
Eye problems/disorders: None of the above	0.8	0.9	1.7	0.7	-0.7	1.3
Knee pain experienced in last month	0.8	1.3	2.0	1.4	-1.1	0.8
Osteoporosis (self-reported)	0.8	1.0	2.1	0.7	0.5	1.4
Number of self-reported non-cancer illnesses	0.8	1.3	2.7	1.6	0.6	1.0
Hearing aid user	0.8	0.9	2.0	-1.4	0.8	-0.3
Irritability	0.8	1.3	1.8	1.3	1.4	0.8
Irritable Bowel Disease (IBD)	0.7	1.6	3.2	1.1	0.7	1.8
Breast Cancer	0.7	1.7	3.9	-0.9	-2.0	-0.7
Blood Eosinophil Count	0.7	5.3	7.7	2.4	1.6	2.8
Blood White Count	0.7	5.2	11.1	-1.8	3.3	1.1
Hand grip strength (left)	0.7	1.9	5.2	0.8	-2.3	0.0
Systolic blood pressure, automated reading	0.7	2.1	4.2	-1.1	2.0	1.0
Current tobacco smoking	0.7	1.2	3.0	-0.3	0.7	-1.7
Maternal smoking around birth	0.7	1.1	2.4	-0.6	-1.6	0.6
Medication: Atenolol	0.7	0.9	2.4	0.3	-1.6	0.4
Medication: Levothyroxine sodium	0.7	1.2	1.4	1.2	1.2	1.0
Impedance of leg (left)	0.7	3.5	5.4	-2.3	1.2	-1.9
Nervous feelings	0.7	1.2	2.7	-1.6	0.9	0.4
Illnesses of siblings	0.7	0.9	1.5	-0.5	-1.2	1.0
Impedance of arm (right)	0.7	3.3	7.6	-1.3	2.8	-0.8
Falls in the last year	0.7	0.9	1.2	0.8	1.0	1.1
Breastfed as a baby	0.7	0.9	1.6	1.0	0.2	-1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	1.5	0.7	-0.3
Number of full brothers	0.7	0.9	1.6	0.0	-1.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.3	1.5	0.1	-0.4
Supplements: Vitamin C	0.7	0.8	1.9	-0.7	1.4	0.3
Qualifications: nursing, teaching	0.7	1.1	2.4	0.9	-0.3	1.6
Illnesses of father: None of the above (group 1)	0.7	0.9	1.9	0.6	-0.7	-1.4
Smoking status: Current	0.7	1.2	3.3	-0.1	0.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.2	-0.1	-1.5	1.5
Number of operations (self-reported)	0.7	1.0	2.0	1.4	-0.2	1.0
Impedance of whole body	0.7	3.7	5.8	-1.9	2.4	-1.3
Trunk fat mass	0.6	2.8	5.6	1.6	-0.3	2.4
Financial difficulties in last 2 years	0.6	0.8	1.6	-0.4	1.3	0.8
Medication: Ramipril	0.6	0.8	1.4	-0.6	-1.2	-0.8
Neuroticism score	0.6	1.1	3.2	-1.8	-0.1	0.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	0.2	0.7	1.2
Medication: Paracetamol	0.6	1.0	2.0	-1.4	0.7	0.7
Gout (self-reported)	0.6	0.8	2.0	1.4	0.1	0.5
Medication: Amlodipine	0.6	0.9	1.8	0.6	1.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	-0.3	-0.1	-1.4
Health satisfaction	0.6	0.8	1.1	1.1	1.0	0.5
Whole body fat mass	0.6	2.6	5.6	1.5	-0.2	2.4
Suffer from ‘nerves’	0.6	1.0	2.4	-1.5	0.8	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.7	-0.5	1.3	-0.4
Arm fat percentage (left)	0.6	2.3	3.5	0.7	1.9	1.7
Medication for cholesterol	0.6	0.9	1.4	-1.1	1.2	0.5
Mother’s age at death	0.6	0.7	2.0	-0.3	-0.4	-1.4
Risk taking	0.6	1.0	1.5	0.6	-1.0	-1.2
Myopia	0.6	0.8	1.8	0.2	0.8	1.4
Supplements: Calcium	0.6	0.6	1.2	-0.8	1.1	0.3
Leg fat mass (left)	0.6	2.4	5.1	1.3	-0.4	2.3
Rheumatoid Arthritis	0.5	0.7	1.8	0.5	0.2	-1.3
Stomach or abdominal pain in last month	0.5	0.7	2.0	-0.0	0.0	1.4
Had other major operations	0.5	0.7	0.9	0.6	-0.8	0.9
Qualifications: None of the above	0.5	1.1	1.9	0.5	-1.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.1	1.4	0.0	0.6
Pulse rate	0.5	0.8	2.3	-1.5	0.4	-0.1
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.4	-0.1	-1.2
Hair/balding pattern: Pattern 4	0.5	1.3	3.3	-1.8	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.7	0.4	0.6	1.3
High blood pressure (siblings)	0.5	0.8	1.9	0.3	1.4	-0.6
Family relationship satisfaction	0.5	0.6	1.0	-1.0	-1.0	-0.1
Loneliness, isolation	0.5	0.7	1.3	-0.6	-0.7	1.1
Ever had bowel cancer screening	0.5	0.6	1.4	0.6	0.4	1.2
Friendships satisfaction	0.5	0.7	1.0	-1.0	1.0	-0.0
Osteoarthritis (self-reported)	0.5	0.6	1.4	-0.6	-1.2	0.2
Wears glasses or contact lenses	0.5	0.6	1.2	-0.3	0.6	1.1
Age started oral contraceptive pill	0.5	0.6	1.3	-0.4	1.2	-0.7
Unable to work because of sickness or disability	0.5	0.7	1.8	1.4	-0.4	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	1.6	-0.9	-1.2	-1.1
Cholesterol lowering medication	0.5	0.7	1.5	-0.2	-0.8	-1.2
Worry (Nagel 2018)	0.4	0.8	1.9	-1.4	0.4	0.6
Blood Red Count	0.4	3.9	9.7	1.3	0.6	3.1
Neuroticism	0.4	1.0	2.5	-1.6	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	0.3	0.5	1.2
Townsend deprivation index at recruitment	0.4	0.6	1.1	1.1	0.7	-0.4
Average weekly fortified wine intake	0.4	0.5	0.8	0.9	0.8	0.2
Fed-up feelings	0.4	0.7	1.5	-1.2	-0.9	0.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.7	0.8	0.2	0.9
High blood pressure	0.4	1.1	2.5	0.4	1.6	0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.8	0.6	0.6
Mouth/teeth dental problems	0.4	0.7	0.9	-0.9	0.9	-0.6
Arm fat percentage (right)	0.4	1.5	2.2	0.5	1.5	1.5
Time employed in main current job	0.4	0.5	1.3	-0.1	0.4	1.1
Happiness	0.4	0.5	1.5	0.1	-0.1	1.2
Prospective memory result	0.4	0.5	1.0	-0.2	0.7	1.0
Illnesses of mother	0.4	0.5	1.1	1.1	-0.4	-0.4
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.7	-0.9	0.5
Leg fat mass (right)	0.4	1.7	3.8	1.0	-0.6	1.9
Number of full sisters	0.4	0.5	0.9	0.8	-1.0	-0.1
Had major operations	0.4	0.4	1.1	-0.3	1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	-0.9	-0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.5	-1.1	0.1
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.7	-0.8	-0.4	-0.7
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.4	-1.1	0.2
Financial situation satisfaction	0.4	0.4	0.6	-0.7	-0.5	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	-0.4	1.0	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.7	0.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.8	0.9	0.6	0.5
Depression (Nagel 2018)	0.3	0.4	1.0	0.0	-0.4	1.0
Major Depression (MDD)	0.3	0.3	0.7	-0.3	0.4	-0.8
Crohns Disease (2012)	0.3	0.5	1.1	0.7	0.1	1.1
HbA1C	0.3	0.3	0.9	0.2	-0.1	-0.9
Allergy or Eczema	0.3	0.8	1.5	-0.1	1.2	1.0
Respiratory disease	0.3	0.7	1.1	0.9	-0.3	1.1
Trunk fat percentage	0.3	1.2	2.3	0.1	1.2	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.1	0.4	1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.7	0.6	0.3	-0.9
Body mass index (BMI)	0.3	1.4	3.2	0.9	0.3	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.6	-1.1	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	0.3	-1.2	-0.2
Medication: Cholesterol lowering	0.3	0.5	1.0	-1.0	-0.7	-0.1
Pulse wave reflection index	0.3	0.4	0.9	0.2	0.3	-0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.3	1.1	0.6	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	1.2	-0.5	0.2
Comparative body size at age 10	0.3	0.9	2.4	1.5	-0.0	0.6
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	-0.6	1.1	0.2
Pulse wave peak to peak time	0.3	0.4	1.2	0.0	-1.1	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.6	0.3	-0.8	0.4
Overall health rating	0.3	0.7	1.8	0.5	-1.3	-0.3
Hypertension (Self-reported)	0.3	0.8	1.7	0.1	1.3	0.8
Average weekly red wine intake	0.3	0.4	1.1	-1.0	-0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.5	-0.4	0.9
Medication: Paracetamol	0.3	0.4	1.2	-1.1	0.1	0.2
Medication: Lisinopril	0.3	0.4	0.5	-0.7	-0.6	0.4
Commuting to job workplace: Cycle	0.3	0.3	0.4	0.4	0.7	0.6
Ulcerative Colitis (UC)	0.2	0.3	0.9	1.0	0.2	0.2
Age at First Birth	0.2	0.3	0.7	0.6	0.8	-0.2
HDL Cholesterol	0.2	0.3	0.4	-0.7	-0.1	-0.6
Triglycerides	0.2	0.3	0.8	-0.0	0.1	-0.9
Ulcerative Colitis	0.2	0.3	1.0	0.1	0.1	-1.0
BMI	0.2	1.0	2.8	0.5	0.2	1.7
Waist Hip Ratio (WHR)	0.2	0.9	1.4	0.8	0.8	1.2
Number of treatments/medications taken	0.2	0.4	1.1	-0.1	1.1	-0.0
Hearing difficulty/problems: Yes	0.2	0.3	0.4	0.6	-0.4	0.5
Taking other prescription medications	0.2	0.3	0.5	0.7	0.2	0.6
Supplements: Glucosamine	0.2	0.2	0.4	0.4	0.7	0.4
Had menopause	0.2	0.3	0.4	-0.4	-0.6	-0.5
Allergy	0.2	0.4	0.9	0.3	0.9	0.5
Medication: Simvastatin	0.2	0.3	0.6	-0.4	0.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	-0.8	-0.0	0.4
Body fat percentage	0.2	1.0	1.5	-0.2	1.2	1.2
Alcohol intake frequency.	0.2	0.4	0.7	-0.7	0.4	-0.8
Leg pain on walking	0.2	0.3	0.4	0.6	-0.5	0.4
Medication: Aspirin	0.2	0.2	0.4	-0.6	-0.0	0.6
Illnesses of father: Heart disease	0.2	0.2	0.6	0.2	0.1	0.8
Mood swings	0.2	0.4	0.6	-0.2	0.8	-0.8
Mineral and other dietary supplements	0.2	0.2	0.3	0.3	-0.6	0.5
Medication: Aspirin	0.2	0.3	0.4	-0.6	-0.5	0.4
Guilty feelings	0.2	0.3	0.4	-0.5	-0.5	0.6
Medication: Blood pressure	0.2	0.4	0.5	0.7	-0.6	0.5
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	0.5	-0.0
Leg fat percentage (left)	0.2	0.7	1.0	-0.3	1.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.7	-0.5	0.4
Heart disease (siblings)	0.2	0.2	0.5	0.7	-0.4	0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.8	0.2	0.1
Neuroticism (Nagel 2018)	0.1	0.1	0.2	-0.5	-0.1	0.4
Mean Putamen Volume	0.1	0.1	0.3	-0.2	-0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.1	0.4	0.6
Tanning	0.1	1.5	3.9	0.4	-2.0	-0.8
Supplements: Zinc	0.1	0.1	0.3	-0.0	-0.3	-0.6
Medication: Co-codamol	0.1	0.2	0.3	-0.4	0.5	0.3
Medication: Metformin	0.1	0.1	0.2	-0.5	-0.1	0.2
Diabetes (mother)	0.1	0.1	0.3	-0.0	-0.6	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.7	-0.8	0.1	-0.2
Alcohol usually taken with meals	0.1	0.1	0.4	0.0	0.1	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.0	-0.6	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	0.3	-0.2
Noisy workplace	0.1	0.1	0.3	-0.1	-0.6	0.3
Asthma	0.1	0.2	0.3	0.4	0.4	0.5
Depression (self-reported)	0.1	0.1	0.2	-0.4	0.2	0.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.2	0.7	0.1
Leg fat percentage (right)	0.1	0.5	0.7	-0.6	0.8	0.7
Medication: Blood pressure	0.1	0.1	0.3	-0.3	0.2	0.5
Medication: Allopurinol	0.1	0.2	0.3	0.4	0.3	0.6
Medication: Omeprazole	0.1	0.1	0.3	0.6	-0.2	-0.0
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.4	-0.1	0.6
Back pain experienced in last month	0.1	0.2	0.5	-0.7	-0.3	-0.3
Asthma (self-reported)	0.1	0.1	0.2	0.4	0.3	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.4	0.5	0.0
Basal cell carcinoma (self-reported)	0.1	0.2	0.2	-0.4	0.5	0.4
Hair Pigment	0.0	0.5	0.8	0.7	0.9	0.2
Average weekly spirits intake	0.0	0.1	0.1	0.1	-0.2	0.4
Diabetes (father)	0.0	0.1	0.1	-0.3	0.3	-0.1
Diabetes (self-reported)	0.0	0.0	0.0	0.1	0.0	0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.2	-0.0	-0.0
Shortness of breath walking on level ground	0.0	0.1	0.1	-0.1	0.3	-0.2

Hub : Genes

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Trait associations