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chr11:64,407,419-66,333,072

Best TWAS P=3.07e-11 · Best GWAS P=6.89e-12 conditioned to 5.06e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	5.4	5.4	5.6e-08	-0.18	0.33	0.10	FALSE
2	GTEx	Brain Cerebellum	EFEMP2	0.45	0.40	enet	8	0.39	1.6e-12	5.2	5.1	2.7e-07	-0.17	0.95	0.05	FALSE
3	GTEx	Colon Transverse	DPF2	0.19	0.01	lasso	4	0.05	1.6e-03	4.4	6.6	3.1e-11	0.00	0.07	0.29	TRUE
4	GTEx	Esophagus Mucosa	DPF2	0.12	0.02	lasso	4	0.03	6.2e-03	-4.6	5.5	2.9e-08	-0.15	0.12	0.08	FALSE
5	GTEx	Skin Sun Exposed Lower leg	KCNK7	0.07	0.03	lasso	5	0.02	1.6e-02	5.2	5.2	2.0e-07	-0.11	0.24	0.53	FALSE
6	GTEx	Testis	DPF2	0.20	0.09	lasso	7	0.06	9.5e-04	-4.1	5.2	2.0e-07	-0.14	0.14	0.14	FALSE
7	METSIM	Adipose	EFEMP2	0.07	0.05	lasso	8	0.04	4.2e-06	4.7	5.2	1.5e-07	-0.25	0.99	0.01	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	5.6	5.3	1.4e-07	-0.20	0.04	0.95	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	POLA2	0.01	0.01	blup	34	0.02	2.6e-04	-4.7	5.3	1.1e-07	-0.08	0.10	0.86	FALSE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	POLA2	0.05	0.02	blup	36	0.05	2.2e-03	-4.6	5.2	1.5e-07	-0.07	0.03	0.65	FALSE
11	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	4.1	-5.2	1.6e-07	0.20	0.16	0.65	FALSE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	DKFZp761E198	0.14	0.00	blup	39	0.05	1.4e-02	-4.7	-5.4	6.5e-08	0.33	0.01	0.41	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DKFZp761E198	0.07	0.02	blup	39	0.03	5.9e-04	-4.8	-5.3	1.4e-07	0.35	0.01	0.72	TRUE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DPF2	0.03	0.03	lasso	2	0.03	5.6e-04	-5.3	5.4	5.4e-08	-0.06	0.00	0.95	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLA2	0.04	0.01	lasso	3	0.02	8.7e-04	-5.0	5.2	1.9e-07	-0.09	0.18	0.55	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPF2	0.07	0.04	blup	28	0.04	2.9e-05	-5.3	5.7	1.2e-08	-0.04	0.00	0.99	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPF2	0.03	0.02	blup	28	0.02	1.2e-03	-5.3	6.0	1.9e-09	-0.04	0.00	0.96	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	FIBP	0.02	0.01	blup	45	0.02	1.3e-03	3.5	5.2	2.5e-07	-0.24	0.06	0.47	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CAPN1	0.03	0.02	blup	39	0.02	2.1e-03	-5.7	-6.5	8.2e-11	0.19	0.00	0.97	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POLA2	0.12	0.03	enet	9	0.05	2.5e-04	-5.3	5.9	3.6e-09	-0.12	0.03	0.58	FALSE
21	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CTSW	0.16	0.10	enet	24	0.15	1.9e-06	3.3	-5.2	2.2e-07	0.13	0.61	0.15	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPF2	0.09	0.06	enet	4	0.10	1.3e-10	-5.3	5.1	2.7e-07	-0.07	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	POLA2	0.09	0.06	blup	34	0.08	1.4e-05	-5.8	6.0	2.3e-09	-0.15	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	DPF2	0.05	0.02	blup	29	0.03	3.7e-04	-5.3	5.9	3.1e-09	-0.03	0.00	0.95	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	FIBP	0.04	0.00	blup	45	0.02	8.0e-03	4.2	5.5	4.0e-08	-0.25	0.02	0.06	TRUE