Hub : Genes

KCNK7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.2790 0.0990 4.4e-03 -0.012 NA 0.014 NA -0.006 0.84000 NA 1.5e-01 NA 0.47000
2 GTEx Esophagus Gastroesophageal Junction 0.2770 0.0840 3.8e-04 0.008 NA 0.146 NA 0.054 0.16000 NA 5.9e-06 NA 0.00490
3 GTEx Esophagus Muscularis 0.1730 0.0530 3.3e-05 0.023 NA 0.105 NA 0.059 0.01500 NA 6.5e-07 NA 0.00019
4 GTEx Skin Sun Exposed Lower leg 0.0680 0.0320 7.4e-03 0.034 NA -0.001 NA 0.016 0.00073 NA 3.9e-01 NA 0.01600
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0430 0.0247 2.4e-04 0.009 0.013 0.011 NA 0.004 0.02600 0.01200 1.9e-02 NA 0.09800
6 TCGA Lung Adenocarcinoma 0.0338 0.0222 2.9e-03 0.003 0.022 0.027 NA 0.010 0.12000 0.00110 3.9e-04 NA 0.02100
7 TCGA Prostate Adenocarcinoma 0.0406 0.0297 1.9e-03 0.023 0.031 0.020 NA 0.022 0.00160 0.00031 3.4e-03 NA 0.00190

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.4 0.8 -0.9 0.9 -0.9 0.3 -0.1 0.2 -0.3
Bipolar Disorder or Schizophrenia 1.5 3.8 8.6 -2.9 -0.3 -2.3 1.9 -1.7 -1.3 -2.0
Depressed Affect (Nagel 2018) 3.0 6.2 12.5 -0.5 -3.5 -3.1 2.8 -2.0 -0.7 -3.0
Depression (Nagel 2018) 1.2 1.9 4.7 -1.4 -1.3 -2.2 1.4 -0.4 -0.5 -1.5
Intelligence (Savage-Jansen 2018) 0.3 0.8 4.7 2.2 -0.7 -0.4 -0.0 0.1 0.3 0.3
Neuroticism (Nagel 2018) 1.0 2.4 6.4 0.1 -2.4 -2.5 1.3 -0.7 0.0 -1.6
Schizophrenia (2018) 2.3 4.8 9.3 -3.0 -0.9 -2.2 2.3 -2.2 -1.8 -2.4
Schizophrenia vs Biploar Disorder 2.0 2.6 7.4 -2.7 -1.0 -0.2 1.5 -1.5 -1.8 -1.5
Worry (Nagel 2018) 0.3 0.6 2.2 -0.3 -1.5 -1.3 0.4 0.2 -0.2 -0.1
Alzheimer’s Disease (in mother) 0.8 1.0 4.5 0.8 -2.1 -0.3 -0.6 0.7 -0.7 0.4
Alzheimer’s Disease (in father) 0.3 0.3 0.9 0.5 -0.7 0.4 0.1 -1.0 0.4 0.1
Alzheimer’s Disease (including proxy) 1.1 1.6 9.4 0.8 -3.1 -0.3 0.1 -0.5 -0.8 -0.2
Crohns Disease (2017) 0.2 0.5 1.9 0.2 1.4 0.5 0.5 0.7 -0.6 0.4
Irritable Bowel Disease (IBD) 0.1 0.3 0.9 -0.5 0.9 -0.3 0.8 0.5 -0.2 0.1
Ulcerative Colitis (UC) 0.1 0.3 0.8 -0.9 0.6 -0.4 0.5 0.2 0.6 0.1
Major Depression (MDD) 1.6 2.0 4.2 -1.9 -0.0 -2.0 0.0 -1.3 -0.5 -2.0
Reaction Time 2.7 5.2 12.8 -3.6 0.6 -1.8 1.9 -2.5 -2.1 -2.3
Verbal and Numeric Reasoning (VNR) 0.6 1.5 6.3 2.5 -1.6 0.7 -0.0 0.3 0.8 0.8
Breast Cancer 3.3 7.8 15.1 2.5 1.2 -0.1 -3.9 3.5 3.6 2.6
Ovarian Cancer 0.3 0.4 0.8 -0.1 0.4 -0.3 0.9 -0.3 0.9 -0.8
Prostate Cancer 1.2 1.7 6.7 -0.8 0.0 -0.8 1.3 -1.3 -2.6 -0.9
Age at First Birth 0.1 0.2 0.7 0.4 -0.8 -0.1 -0.2 -0.6 -0.3 0.2
Bipolar Disorder (2011) 0.4 0.4 1.2 1.1 1.0 -0.6 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.9 2.5 7.6 -1.8 -1.1 -2.4 2.8 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.4 0.5 3.3 -0.0 0.4 1.8 -0.5 0.0 0.0 0.0
Crohns Disease (2012) 0.2 0.4 1.9 0.1 1.4 0.6 0.2 0.4 -0.3 0.2
Mean Putamen Volume 2.1 2.4 4.7 -2.2 0.0 -1.4 1.9 -1.4 -0.9 -2.0
Fasting Glucose 1.1 1.3 2.5 -0.2 -0.7 -1.4 1.6 -1.6 -0.3 -1.3
HbA1C 0.2 0.2 0.4 0.6 -0.6 -0.3 -0.1 -0.4 0.4 -0.4
HDL Cholesterol 2.1 3.4 13.4 1.9 1.2 2.3 -3.7 0.0 0.0 0.0
LDL Cholesterol 0.9 1.4 3.3 -1.7 -1.8 -1.1 1.6 0.0 0.0 0.0
Lupus 1.6 2.5 5.6 -1.5 -0.3 -1.3 2.0 -2.4 -0.1 -1.9
Neuroticism (2016) 0.4 0.5 1.2 0.5 -0.3 -1.1 0.7 -0.8 0.4 -0.8
Primary Biliary Cirrhosis 2.8 4.0 6.8 -1.7 -1.8 -2.4 2.6 -1.8 -0.7 -2.4
Rheumatoid Arthritis 0.6 0.8 2.7 0.3 -1.6 0.3 0.3 0.2 1.5 0.6
Schizophrenia (2014) 2.2 4.9 9.5 -3.1 -0.7 -1.9 2.7 -2.6 -1.4 -2.2
Triglycerides 1.3 2.2 7.5 -1.3 -2.7 -1.2 2.2 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 3.5 4.1 12.1 -2.7 -1.6 -2.5 3.5 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.2 0.4 -0.6 -0.2 -0.4 0.0 0.5 0.6 0.4
Blood Eosinophil Count 4.5 34.9 73.8 5.8 -2.5 -0.4 -7.7 6.1 8.6 5.8
Blood Platelet Count 8.6 99.3 163.8 8.8 1.5 8.6 -11.6 12.8 9.8 12.2
Blood Red Count 2.5 24.0 33.2 -0.7 -5.5 -5.0 5.5 -5.8 -5.2 -4.7
Blood White Count 0.6 4.6 11.0 0.6 -1.5 -0.5 -2.3 3.3 2.8 2.2
Heel T-Score 3.6 28.4 62.4 -1.0 -3.9 -7.9 3.9 -6.9 2.8 -7.0
BMI 2.0 11.5 26.2 -2.2 -1.1 -2.7 4.8 -2.6 -3.4 -5.1
Height 0.8 15.0 66.3 3.4 -8.1 1.3 2.7 -0.5 4.3 0.1
Waist Hip Ratio (WHR) 2.9 13.2 34.5 -2.4 -2.2 -4.1 3.4 -5.9 -0.4 -4.3
Systolic Blood Pressure 2.0 10.2 40.2 -3.0 -0.3 -1.3 3.1 -6.3 -1.0 -3.1
Smoking Status 3.1 7.5 17.8 -0.8 -1.8 -2.9 4.2 -3.1 -1.6 -3.1
Allergy or Eczema 1.4 3.7 15.9 1.0 -1.5 -4.0 -1.1 0.4 2.2 -0.7
Cardiovascular Disease 1.3 4.2 13.2 -1.0 0.1 -2.7 1.9 -3.6 -0.4 -2.1
Hypothyroidism (self reported) 1.7 3.8 12.1 2.4 -3.5 -1.2 -1.1 1.1 2.2 0.1
Respiratory disease 1.1 2.4 9.4 0.7 -1.5 -3.1 -0.2 0.1 1.3 -1.8
Type 2 Diabetes (T2D) (2018) 7.6 14.2 28.9 -2.7 -1.0 -3.8 3.8 -4.9 -3.1 -5.4
Lung FEV1/FVC ratio 0.6 2.8 12.3 -0.1 3.5 1.6 0.6 -1.4 -1.4 0.6
Lung FVC 1.8 8.9 21.2 -2.1 -4.6 -3.1 3.0 -3.1 -0.2 -3.0
Neuroticism 1.1 2.6 8.5 0.8 -2.9 -2.5 1.1 -0.1 0.5 -1.0
Chronotype (morning person) 0.9 2.0 3.4 0.1 -0.6 1.6 -1.5 1.7 1.8 1.6
Hair Pigment 0.7 20.6 44.0 2.4 3.1 6.2 -4.1 6.6 0.9 5.4
Tanning 0.1 1.0 2.6 -1.6 -0.2 -1.3 0.8 -0.2 -1.1 -0.7
Hand grip strength (left) 0.8 2.1 11.8 0.8 -3.4 0.2 1.4 0.2 0.2 -0.6
Number of treatments/medications taken 0.6 1.0 4.2 0.5 0.6 -1.3 0.2 -0.8 2.0 -0.3
Average weekly spirits intake 0.7 0.8 2.6 -0.5 1.6 0.8 1.1 -0.3 0.1 -1.0
Sensitivity / hurt feelings 0.9 1.5 3.1 0.7 -1.0 1.1 -0.6 1.8 1.4 1.4
Frequency of depressed mood in last 2 weeks 1.4 1.9 3.4 -1.9 -1.1 -1.7 1.7 -0.8 -0.7 -1.4
Hearing difficulty/problems: Yes 0.5 0.7 2.0 0.5 1.4 -0.5 -1.1 1.0 0.7 0.4
Relative age of first facial hair 1.5 3.1 9.8 -0.2 2.5 3.1 -0.9 1.6 -0.9 1.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.8 -0.7 0.1 -0.8 1.6 -1.7 -0.9 -1.3
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.9 1.6 0.9 0.2 -1.4 2.0 2.2 1.0
Ever had hysterectomy (womb removed) 0.6 0.6 1.6 0.1 1.2 1.3 0.0 0.1 0.7 0.8
Systolic blood pressure, automated reading 2.6 7.5 23.3 -2.7 -0.4 -1.3 3.1 -4.8 -1.1 -3.1
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 6.3 -1.0 -0.9 -2.4 1.9 -1.5 -0.2 -2.5
Angina 0.2 0.2 1.0 0.6 -0.0 0.0 -0.1 -0.5 0.2 1.0
Medication for hormone replacement therapy 1.3 1.4 3.5 0.9 0.2 1.3 -1.2 1.3 1.9 1.1
Vitamin and mineral supplements 0.6 0.8 2.7 0.4 -0.2 1.6 -1.2 0.5 -0.5 0.8
Supplements: Zinc 0.2 0.2 1.0 -0.2 -0.3 -0.3 0.4 0.2 -1.0 -0.3
Medication: Co-codamol 2.8 3.2 5.7 -2.4 -0.7 -1.0 2.2 -2.1 -2.0 -1.4
Medication: Metformin 4.4 6.2 12.2 -2.4 -0.7 -2.1 2.2 -3.2 -2.3 -3.5
Diabetes (father) 7.5 9.3 13.5 -3.5 -0.0 -3.2 3.2 -3.2 -3.0 -3.7
Diabetes (mother) 3.2 4.1 8.8 -0.7 -1.5 -2.6 1.9 -2.5 -0.6 -3.0
Severe depression (siblings) 0.5 0.6 1.7 1.3 1.3 -0.2 -0.3 0.8 -0.2 -0.0
Pack years adult smoking proportion 1.6 2.4 7.0 0.1 -2.6 -1.1 1.4 -1.2 -1.6 -1.6
Impedance of leg (right) 1.4 6.9 18.8 1.0 -1.8 1.3 -3.2 1.9 4.3 3.1
Leg fat-free mass (left) 1.4 7.2 19.3 -1.0 -2.6 -1.1 4.4 -2.4 -1.9 -3.6
Trunk fat percentage 0.7 3.0 6.8 -1.5 -1.1 -1.5 2.6 -1.4 -0.2 -2.5
Hand grip strength (right) 1.2 3.4 14.9 0.4 -3.9 -1.1 1.9 -0.9 0.6 -1.5
Townsend deprivation index at recruitment 0.9 1.2 2.7 0.3 -1.6 -1.6 0.9 -1.2 0.2 -1.1
Current tobacco smoking 4.0 6.6 12.0 -2.4 -0.9 -1.7 3.5 -2.7 -2.5 -3.2
Average weekly fortified wine intake 2.2 2.6 4.5 1.0 1.3 1.4 -1.3 2.1 1.8 2.0
Maternal smoking around birth 0.4 0.6 1.8 1.3 -1.3 0.1 0.1 0.7 0.6 0.2
Fed-up feelings 3.3 6.0 16.5 0.6 -4.1 -2.0 3.0 -2.2 -1.1 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 3.0 4.0 7.2 -1.5 -1.4 -2.7 2.1 -1.5 -1.8 -2.6
Relative age voice broke 1.1 1.7 4.3 -1.4 1.9 2.1 -0.1 0.3 -1.3 0.5
Taking other prescription medications 0.4 0.6 1.3 0.3 0.1 -1.1 0.9 -0.8 0.6 -0.9
Age when periods started (menarche) 5.0 12.1 21.7 1.9 0.2 4.0 -4.0 4.3 3.0 4.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.9 -0.3 0.4 -0.7 1.4 -1.3 -0.7 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 4.1 9.3 18.5 -0.4 -3.2 -4.3 2.6 -3.6 1.5 -3.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.1 -0.5 -0.1 0.6 -0.6 -0.4 -0.6
Qualifications: CSEs or equivalent 2.6 3.4 5.2 -2.3 -2.0 -1.3 2.1 -2.2 -1.2 -1.5
Serious illness, injury or assault to yourself 2.7 3.3 6.7 -1.7 0.5 -1.6 2.1 -2.2 -1.2 -2.6
High blood pressure 0.7 1.9 6.9 -0.3 0.8 -1.7 1.2 -2.6 0.3 -1.2
Hayfever, allergic rhinitis or eczema 1.6 3.5 10.1 1.2 -2.4 -3.2 -1.2 0.4 2.3 -0.1
Multivitamins +/- minerals 0.3 0.4 1.1 -0.1 -0.2 -1.0 1.0 -0.6 0.3 -0.6
Stomach or abdominal pain in last month 2.8 3.5 6.5 -1.0 0.1 -1.9 2.5 -2.5 -1.6 -2.3
Supplements: Glucosamine 0.2 0.3 1.2 0.2 0.2 -1.1 0.4 -0.6 0.3 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.0 0.2 0.3 -0.5 0.6 -0.4 0.8
Medication: Atenolol 3.0 3.8 6.6 1.6 1.1 2.0 -1.9 1.4 2.6 2.5
Medication: Levothyroxine sodium 1.5 2.6 9.4 1.7 -3.1 -2.0 0.4 0.1 1.1 -0.6
Sitting height 1.6 11.3 29.7 -0.7 -5.5 -2.5 4.2 -3.5 -1.6 -3.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.9 -0.7 0.0 -1.4 0.6 0.0 0.3 -0.7
High blood pressure (mother) 0.7 0.9 1.7 -0.7 1.3 -1.3 0.5 -0.9 0.2 -1.3
Body mass index (BMI) 2.4 10.4 24.0 -2.4 -0.1 -2.4 4.3 -3.0 -3.2 -4.9
Impedance of leg (left) 1.1 5.5 14.0 1.1 -1.9 0.7 -2.8 1.6 3.7 2.9
Leg predicted mass (left) 1.3 6.8 18.5 -0.9 -2.5 -1.0 4.3 -2.3 -1.9 -3.5
Trunk fat mass 1.5 6.4 15.3 -1.7 -2.1 -1.7 3.9 -2.4 -1.1 -3.6
Waist circumference 2.9 10.8 22.5 -2.0 -2.0 -3.0 4.4 -3.8 -1.5 -4.7
Number of incorrect matches in round 3.4 5.6 7.5 1.3 2.1 2.3 -2.4 2.7 2.7 2.7
Past tobacco smoking 2.2 4.0 7.9 0.5 1.3 2.4 -2.8 2.6 0.9 2.1
Alcohol usually taken with meals 0.6 0.9 1.8 1.4 0.7 0.8 -1.1 0.7 1.0 1.0
Nervous feelings 0.5 1.0 1.8 0.6 -1.1 -0.8 -0.8 1.0 1.0 1.4
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 6.9 -0.5 -1.1 -2.6 2.5 -1.2 -1.8 -2.2
Hearing difficulty/problems with background noise 0.4 0.6 1.4 1.1 1.2 -0.6 -1.0 0.4 -0.2 0.3
Hair/balding pattern: Pattern 2 0.7 1.0 2.0 0.1 -1.4 1.0 -0.2 1.3 0.8 1.2
Had menopause 2.3 2.9 8.1 1.0 1.2 0.1 -1.8 2.8 2.1 1.4
Had other major operations 0.7 0.8 2.9 1.7 0.5 0.9 -1.0 0.2 0.5 0.6
Forced vital capacity (FVC) 2.0 7.6 30.2 -0.3 -5.5 -2.0 2.8 -2.6 0.9 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 2.8 6.5 12.0 -0.7 -2.4 -3.5 2.0 -3.2 1.6 -3.2
Ever unenthusiastic/disinterested for a whole week 2.2 2.6 5.3 -1.4 0.9 -2.3 1.2 -0.9 -1.9 -2.2
Qualifications: None of the above 0.3 0.7 1.8 -1.3 -1.3 -0.0 0.7 -0.7 -0.3 -0.5
Financial difficulties in last 2 years 3.2 4.2 6.7 -0.0 -2.6 -2.2 2.5 -2.1 -1.5 -2.2
Mouth/teeth dental problems 7.8 12.0 20.3 1.7 1.0 4.5 -4.0 3.5 3.7 4.2
Heart attack 0.4 0.6 2.4 1.0 0.3 -0.4 0.3 -1.5 -0.1 0.5
Allergy 1.4 3.2 8.0 -1.4 2.0 2.8 1.2 -0.6 -2.5 0.5
Pain all over the body in last month 0.5 0.5 1.6 -1.2 -0.3 0.3 0.6 -1.3 -0.4 -0.3
Diabetes (self-reported) 3.4 5.3 11.0 -1.8 -0.5 -2.7 2.0 -2.8 -1.9 -3.3
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 8.6 1.3 -2.9 -1.3 -0.5 0.5 1.9 0.9
Medication: Ramipril 1.5 1.9 4.3 -1.3 1.4 -0.4 1.7 -2.1 -0.8 -1.3
Medication: Simvastatin 1.4 2.0 4.1 -1.9 0.1 -1.9 0.9 -2.0 -0.2 -1.4
Fluid intelligence score 0.2 0.4 1.1 1.0 -0.5 0.2 0.1 -0.5 0.8 0.6
Illnesses of siblings 0.4 0.5 1.8 -1.3 0.0 0.9 -0.0 0.5 -0.6 0.5
Neuroticism score 1.3 2.8 9.4 0.3 -3.1 -2.3 1.7 -0.7 0.0 -1.2
Weight 2.4 11.8 26.5 -1.7 -3.0 -2.1 5.2 -3.4 -2.2 -4.9
Impedance of arm (right) 4.9 22.8 42.5 2.7 0.3 2.6 -6.3 5.0 6.2 6.5
Arm fat percentage (right) 0.9 3.7 8.9 -1.7 0.2 -1.9 2.3 -1.6 -1.4 -3.0
Trunk fat-free mass 2.0 11.2 24.2 -0.5 -4.2 -1.4 4.9 -3.1 -2.4 -4.3
Hip circumference 0.5 2.2 7.7 -0.5 -1.8 -0.2 2.8 -0.7 0.0 -1.9
Time employed in main current job 0.3 0.3 1.0 0.2 0.3 -0.3 -0.5 1.0 0.8 0.3
Alcohol intake versus 10 years previously 2.3 3.5 7.7 -1.5 -0.9 -1.9 2.6 -2.8 0.2 -1.8
Father’s age at death 3.8 5.1 9.1 2.8 -0.1 2.1 -2.5 3.0 0.9 2.7
Worrier / anxious feelings 1.0 1.9 4.4 1.6 -1.7 0.1 -0.9 2.1 1.1 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 4.3 1.0 -2.0 -1.9 2.1 -1.8 -0.1 -1.4
Falls in the last year 2.4 3.3 5.7 0.9 0.6 1.6 -2.4 2.4 2.0 2.0
Hair/balding pattern: Pattern 3 1.0 1.5 3.7 -0.2 0.1 -1.9 0.5 -1.2 -1.9 -1.0
Number of live births 0.3 0.4 1.4 1.2 0.1 0.1 -0.7 0.5 -0.1 0.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 8.6 -0.2 -2.9 -1.1 1.9 -2.1 0.3 -0.8
Pulse rate 1.5 2.6 10.2 -0.5 3.2 0.6 -1.3 1.8 0.3 1.4
Happiness 1.3 1.6 3.1 0.7 -0.4 -1.8 1.1 -1.5 -1.5 -1.4
Noisy workplace 0.5 0.6 1.4 -0.6 1.1 1.2 -0.1 0.7 0.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.9 2.0 9.6 1.9 3.1 -0.2 -0.1 0.1 -0.5 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 0.1 0.5 -0.2 -0.7 0.7 -0.1 0.3
Mouth/teeth dental problems: Dentures 2.1 3.6 9.0 -1.0 -0.8 -1.8 2.4 -2.0 -1.2 -3.0
Asthma 2.0 3.9 16.0 0.6 -2.0 -4.0 0.1 0.0 0.5 -2.6
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 -0.3 -0.3 -0.4 0.6 0.5 0.9 0.5
Medication: Cholesterol lowering 1.3 2.0 4.4 -1.3 2.1 -1.6 0.7 -2.0 0.2 -0.5
Depression (self-reported) 0.5 0.6 2.7 0.1 -0.2 -1.7 0.6 -0.1 0.5 -0.9
Medication: Lansoprazole 0.8 0.9 2.6 -1.0 0.5 0.5 0.8 -1.3 -1.6 -0.3
Prospective memory result 1.2 1.4 2.7 -1.2 0.8 1.5 -1.0 1.3 1.7 0.5
Lung cancer (father) 1.1 1.2 6.2 -0.6 -0.3 0.8 1.1 -0.6 -2.5 -0.0
Illnesses of mother 0.3 0.4 1.1 0.3 -0.6 0.6 -0.4 1.0 0.2 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 6.5 -0.5 -2.5 -1.1 1.9 -1.8 -0.5 -0.9
Pulse wave Arterial Stiffness index 0.8 1.0 4.2 0.7 -2.0 -0.6 1.2 -0.5 0.3 0.3
Impedance of arm (left) 4.4 20.4 38.6 2.4 0.5 2.8 -5.8 4.6 6.0 6.2
Arm fat mass (right) 2.0 8.4 19.4 -2.0 -1.0 -2.4 4.0 -2.8 -2.2 -4.4
Trunk predicted mass 2.0 11.3 24.6 -0.5 -4.3 -1.4 5.0 -3.1 -2.4 -4.3
Standing height 0.9 9.0 48.6 1.4 -7.0 0.3 2.5 -1.3 1.9 -0.5
Length of working week for main job 1.1 1.2 3.3 -0.1 -0.4 -1.3 1.8 -0.7 -0.7 -1.6
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.7 0.8 0.7 -0.2 -0.3 -0.2 -0.2
Breastfed as a baby 2.1 2.6 5.2 0.9 0.3 1.2 -2.2 2.2 0.6 2.3
Tense / ‘highly strung’ 0.6 1.1 4.3 0.8 -1.0 -2.1 0.2 0.2 1.1 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.6 5.5 9.4 -1.3 -1.4 -2.4 3.0 -1.9 -2.5 -3.1
Hair/balding pattern: Pattern 4 1.0 2.4 4.4 1.8 0.9 1.9 -2.1 0.9 0.6 1.9
Birth weight of first child 2.3 4.2 8.2 -0.4 -1.4 -2.1 2.4 -1.6 -2.9 -2.4
Peak expiratory flow (PEF) 0.7 1.6 4.6 -1.1 -0.7 -0.5 1.9 -2.1 -0.3 -0.9
Pulse wave reflection index 2.3 2.8 10.4 0.3 -3.2 -1.3 1.8 -1.8 -1.0 -0.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.1 0.2 0.2 -2.0 1.0 -0.6 -1.4 -1.1
Loud music exposure frequency 1.8 2.0 5.5 1.9 -0.6 -0.7 -1.4 1.3 2.3 0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.9 1.6 1.7 -0.5 0.4 0.2 0.1 -0.3
Mouth/teeth dental problems: Bleeding gums 5.7 7.4 10.9 -1.4 -1.0 -3.2 3.1 -2.8 -3.3 -3.3
Blood clot in the leg (DVT) 1.6 2.1 5.9 0.7 1.4 2.4 -1.5 1.4 0.9 1.1
Medication: Paracetamol 1.0 1.6 6.4 2.5 -0.9 -0.2 -0.2 0.6 1.8 0.7
Headache pain in last month 1.3 2.2 9.1 1.5 -3.0 -0.8 -0.1 0.8 1.6 -0.3
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 7.2 0.4 -2.7 0.5 -0.4 1.5 -0.3 0.1
Glaucoma (self-reported) 4.1 4.9 11.5 1.8 0.0 1.9 -3.4 2.3 1.9 2.6
Gout (self-reported) 1.8 2.4 6.6 2.6 -1.2 -0.9 -0.5 0.1 2.5 1.3
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 7.8 2.0 -2.8 -1.7 -0.3 0.2 1.5 -0.6
Medication: Amlodipine 0.5 0.7 2.9 1.7 -0.2 0.2 -0.8 -0.4 0.8 0.6
Medication: Ventolin 100micrograms inhaler 1.8 2.3 10.6 0.3 -1.5 -3.2 0.2 0.7 0.3 -1.6
Birth weight 4.4 9.5 19.4 -3.2 -0.1 -2.2 3.9 -1.7 -3.7 -4.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 0.3 -0.5 0.3 0.3 0.7 0.2 0.7
High blood pressure (siblings) 1.2 1.7 4.5 -0.3 0.1 -1.3 1.7 -2.1 -0.2 -1.6
Forced vital capacity (FVC), Best measure 2.3 8.5 28.3 -0.7 -5.3 -2.8 3.0 -2.7 -0.3 -2.5
Body fat percentage 1.2 4.8 10.6 -2.1 -1.0 -1.9 3.0 -2.0 -0.9 -3.3
Leg fat percentage (right) 2.1 7.5 17.3 -2.8 -1.1 -1.9 3.5 -2.6 -2.0 -4.2
Arm fat-free mass (right) 3.4 17.4 39.3 -1.8 -4.0 -1.9 6.3 -4.1 -3.4 -5.6
Exposure to tobacco smoke outside home 0.7 1.0 2.2 0.6 -1.1 -1.5 0.3 0.1 1.1 -1.3
Comparative body size at age 10 3.1 8.5 19.7 -2.5 1.6 -2.0 3.4 -1.4 -4.4 -3.6
Number of full brothers 0.4 0.5 1.7 -0.0 -1.3 -0.1 0.4 -0.8 -0.6 -0.8
Worry too long after embarrassment 0.4 0.6 2.7 0.8 -1.6 -0.7 0.1 0.2 -0.6 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.4 0.8 0.4 -0.4 -0.3 1.0 1.2 0.3
Wheeze or whistling in the chest in last year 0.7 1.2 4.6 -0.4 -0.4 -2.1 0.2 -0.3 -0.2 -1.8
Number of children fathered 3.5 3.9 8.4 -0.9 -2.5 -2.2 2.9 -1.4 -1.1 -2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.3 -0.0 1.1 -0.7 -0.8 1.0 0.3 0.3
Age at first live birth 2.7 4.7 10.2 1.4 0.0 3.2 -2.3 1.9 2.2 2.7
Pulse wave peak to peak time 0.5 0.6 1.7 -0.5 1.3 0.7 -1.2 0.7 0.0 -0.1
Health satisfaction 3.9 5.0 10.2 -3.2 0.6 -1.9 2.3 -1.9 -2.1 -2.7
Shortness of breath walking on level ground 1.0 1.2 4.4 -1.0 -0.5 -0.5 0.6 -0.9 -2.1 -1.1
Qualifications: College or University degree 2.3 7.2 12.8 2.0 3.0 3.2 -3.1 1.7 1.0 3.6
Eye problems/disorders: None of the above 2.2 2.6 8.1 -2.9 0.4 -0.9 1.5 -0.8 -1.6 -1.8
Mouth/teeth dental problems: Loose teeth 2.6 3.1 4.9 0.2 -1.8 -1.9 1.6 -2.2 -1.6 -2.1
Emphysema/chronic bronchitis 0.2 0.2 0.9 -0.3 0.4 0.9 -0.4 -0.5 0.2 0.3
Medication for pain relief, constipation, heartburn 0.7 1.1 3.2 -1.8 0.8 1.5 -0.9 0.6 -0.7 0.3
Neck or shoulder pain in last month 3.4 4.9 8.9 -1.1 -0.6 -3.0 2.8 -2.2 -1.5 -2.9
Medication: Blood pressure 1.0 1.7 9.9 0.5 3.1 0.1 -0.1 -0.9 0.9 0.3
Angina (self-reported) 0.2 0.3 1.0 0.7 -0.1 -0.1 -0.0 -0.7 0.3 1.0
Migraine (self-reported) 0.2 0.2 0.7 0.8 -0.4 -0.0 0.1 0.2 -0.5 -0.5
Medication: Ibuprofen 0.5 0.6 3.0 -0.2 -0.1 0.1 0.0 0.8 1.7 0.9
Medication: Allopurinol 2.1 2.8 8.7 2.5 -1.4 -0.2 -0.7 0.3 3.0 1.5
Medication: Omeprazole 0.5 0.6 1.3 0.4 0.1 -0.5 0.8 -1.1 -1.1 -0.9
Medication: Seretide 50 evohaler 0.4 0.5 1.8 -1.3 0.0 0.1 -0.0 0.7 1.1 0.1
Mean time to correctly identify matches 1.7 3.2 6.7 -2.6 0.7 -1.4 1.4 -1.9 -2.3 -1.7
Heart disease (mother) 0.4 0.5 1.5 0.6 0.3 0.5 -0.8 -0.1 1.2 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.3 -1.5 1.2 -0.7 0.8 -1.2 -1.2 -0.3
Whole body fat mass 2.1 8.8 19.0 -2.4 -2.0 -2.1 4.4 -2.9 -1.6 -4.2
Leg fat mass (right) 2.8 10.7 23.3 -2.6 -1.8 -2.2 4.6 -3.1 -2.5 -4.8
Arm predicted mass (right) 3.2 16.3 37.1 -1.8 -4.1 -1.8 6.1 -3.9 -3.3 -5.3
Pulse rate, automated reading 3.0 9.6 15.1 1.0 3.1 3.5 -3.6 3.7 1.5 3.9
Alcohol intake frequency. 0.5 1.2 2.6 0.9 -1.2 -0.5 1.6 -1.4 0.2 -1.2
Comparative height size at age 10 0.5 2.9 15.5 0.4 -3.9 0.7 1.8 -0.2 0.9 0.4
Number of full sisters 0.5 0.6 1.6 0.5 -0.3 0.3 -1.3 0.8 1.2 0.5
Suffer from ‘nerves’ 0.5 0.7 2.2 -0.2 -1.2 -1.5 0.3 -0.6 -1.1 0.0
Overall health rating 4.6 9.9 16.6 -3.1 -1.4 -3.3 4.0 -3.5 -1.4 -4.1
Chest pain or discomfort 2.3 3.4 7.2 -0.8 -0.9 -2.3 1.9 -2.7 -0.7 -2.4
Had major operations 1.6 1.9 4.9 -0.3 -1.4 -2.2 1.5 -1.3 -0.9 -1.1
Age at last live birth 1.2 1.7 3.2 1.8 -0.1 1.4 -1.4 1.1 0.5 1.8
Family relationship satisfaction 3.3 4.0 6.8 -1.2 1.2 -2.4 1.6 -1.9 -2.6 -2.6
Leg pain on walking 4.2 5.3 7.5 -2.7 -1.2 -2.7 2.3 -2.6 -1.5 -2.6
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.0 -2.0 1.3 -0.6 0.6 -0.0 0.4 -1.2
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.2 -0.0 0.4 -0.2 0.2 0.0 0.1 -0.1
Illness, injury, bereavement, stress in last 2 years 1.8 2.1 7.6 0.3 2.8 1.7 -1.3 1.2 0.2 1.2
Medication: Aspirin 0.5 0.7 2.5 1.6 0.9 -0.2 0.1 -1.0 0.5 -0.0
Supplements: Vitamin C 0.6 0.7 2.8 0.3 -1.7 -1.2 0.6 0.1 0.4 -0.1
Knee pain experienced in last month 3.2 5.0 9.8 -1.5 -1.9 -2.2 3.1 -2.3 -1.6 -2.6
Hypertension (Self-reported) 0.5 1.4 4.6 0.3 0.8 -1.4 0.8 -2.1 1.0 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 4.2 0.8 -0.8 0.1 1.2 -0.9 -2.1 -0.5
Illnesses of father: Heart disease 0.2 0.3 1.0 0.6 0.3 -0.6 -1.0 0.2 0.8 0.2
Illnesses of siblings: Diabetes 1.4 1.8 3.1 0.0 -1.7 -1.7 1.2 -1.4 0.0 -1.8
Smoking status: Previous 1.7 2.5 5.1 0.2 -0.6 -2.2 2.1 -2.2 -0.2 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 5.9 1.2 -2.4 -0.7 0.8 -0.7 0.3 -0.3
Whole body fat-free mass 1.9 10.6 25.4 -0.9 -3.6 -1.3 5.0 -3.1 -2.5 -4.2
Leg fat-free mass (right) 1.4 7.3 19.7 -0.7 -2.6 -1.3 4.4 -2.5 -2.0 -3.5
Arm fat percentage (left) 1.0 4.0 9.8 -1.9 0.2 -1.8 2.5 -1.7 -1.4 -3.1
Average weekly red wine intake 0.8 1.1 2.9 -0.8 0.0 -0.7 0.5 -1.5 -1.7 -1.1
Handedness (chirality/laterality): Left-handed 1.4 1.7 4.4 1.9 0.2 -0.6 -1.2 2.1 0.6 1.3
Mood swings 2.6 4.6 8.4 -0.4 -2.9 -2.5 2.6 -1.7 -0.6 -2.7
Loneliness, isolation 2.1 2.9 6.8 0.4 -2.4 -2.6 1.2 -1.1 -1.2 -2.0
Long-standing illness, disability or infirmity 2.2 3.4 7.8 -2.8 0.0 -0.9 2.2 -2.3 -0.2 -2.3
Ever had bowel cancer screening 0.3 0.4 1.2 -0.2 1.0 1.1 -0.1 -0.5 -0.2 0.3
Diabetes diagnosed by doctor 4.4 7.3 16.2 -2.0 -0.5 -3.1 2.4 -3.2 -2.1 -4.0
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 4.6 1.3 -2.1 0.0 -0.2 0.5 -0.1 0.7
Friendships satisfaction 0.8 0.9 3.8 0.1 0.1 -2.0 -0.1 -0.4 -1.0 -1.2
Qualifications: nursing, teaching 1.6 2.5 7.2 2.7 0.3 1.8 -1.8 1.2 0.5 1.5
Commuting to job workplace: Walk 2.7 2.9 5.7 1.7 1.4 1.0 -2.4 1.7 1.4 1.9
Eye problems/disorders: Cataract 1.4 1.6 9.2 3.0 0.3 0.5 -0.6 -0.0 0.9 0.8
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.8 0.4 -0.4 -1.7 -0.4 0.0 -0.9 0.7
Medication for cholesterol 0.8 1.2 2.9 -0.4 1.7 1.1 -0.4 1.6 -0.9 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.6 0.8 -1.6 -0.6 -0.2 0.2 0.9 0.7
Back pain experienced in last month 1.7 2.4 4.7 -0.7 -2.2 -1.7 2.1 -1.4 -0.2 -1.6
Mineral and other dietary supplements 1.3 1.7 6.5 -1.4 -0.4 0.2 1.0 -0.7 -2.5 -1.4
Breast cancer (self-reported) 3.3 4.0 17.2 -0.2 0.8 4.1 -1.3 2.0 1.3 1.6
Asthma (self-reported) 1.6 3.2 13.2 0.7 -1.8 -3.6 -0.2 0.5 1.1 -2.0
Osteoporosis (self-reported) 2.4 3.0 9.3 -0.7 1.7 3.1 -1.6 1.8 0.6 1.4
Osteoarthritis (self-reported) 0.1 0.2 0.5 -0.1 0.3 -0.6 0.7 -0.1 0.6 -0.1
Medication: Aspirin 1.0 1.3 4.0 2.0 1.4 0.2 -0.6 -0.3 1.3 0.8
Medication: Gliclazide 2.9 3.3 6.3 -2.2 1.7 -1.5 1.7 -1.6 -0.9 -2.5
Illnesses of father: None of the above (group 1) 1.3 1.7 4.3 1.4 -0.2 2.1 -0.8 1.6 -0.3 1.4
Smoking status: Current 3.9 6.2 11.5 -2.4 -0.8 -1.6 3.4 -2.7 -2.6 -3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 2.7 -1.6 0.3 0.2 0.5 -0.7 -0.2 -0.0
Whole body water mass 2.0 11.4 27.0 -0.9 -3.7 -1.3 5.2 -3.2 -2.6 -4.4
Leg predicted mass (right) 1.3 7.1 19.1 -0.7 -2.6 -1.3 4.4 -2.4 -2.1 -3.5
Arm fat mass (left) 1.9 7.6 17.9 -2.0 -1.2 -2.1 3.9 -2.5 -2.1 -4.2
Number of self-reported non-cancer illnesses 0.5 0.8 1.7 1.3 0.2 -1.3 -0.1 -0.9 1.2 -0.4
Average weekly champagne plus white wine intake 2.8 3.8 5.4 2.3 0.5 1.8 -2.1 2.1 2.3 2.1
Miserableness 1.9 3.2 6.1 0.2 -2.4 -2.5 1.9 -1.9 -0.4 -1.8
Guilty feelings 0.4 0.7 2.8 0.7 -0.7 -1.7 0.5 -0.1 0.7 -0.2
Wears glasses or contact lenses 0.7 0.8 2.8 -0.1 1.2 0.9 -0.6 1.7 -0.0 0.7
Ever taken oral contraceptive pill 0.8 0.8 2.2 1.0 -1.1 -1.5 0.5 -0.7 -0.5 -0.6
Hearing aid user 2.1 2.4 5.0 0.4 1.1 1.8 -1.5 1.9 1.1 2.2
Mother’s age at death 0.3 0.4 0.9 -0.1 -0.2 0.9 -0.7 0.7 -0.7 0.7
Financial situation satisfaction 1.4 1.7 2.5 -1.0 0.5 -1.4 1.6 -1.4 -1.3 -1.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.4 1.2 0.4 0.5 -0.8 1.1 -0.1 0.6
Commuting to job workplace: Public transport 0.4 0.5 2.0 0.2 -0.8 -1.4 -0.0 -0.6 0.3 -0.4
Eye problems/disorders: Glaucoma 4.3 5.1 10.8 1.7 0.2 1.5 -3.3 1.9 2.8 2.9
Medication: Blood pressure 1.2 2.3 8.4 0.3 -1.7 -1.4 1.2 -2.9 0.8 -1.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.2 0.4 -1.0 -0.6 1.5 -1.3 -0.1 -0.8
Supplements: Fish oil (including cod liver oil) 2.0 2.6 7.0 1.9 1.1 -0.1 -1.4 1.1 2.6 1.7
High cholesterol (Self-reported) 0.3 0.5 1.8 0.9 -0.7 -1.4 0.0 -0.5 -0.2 -0.5
Medication: Bendroflumethiazide 0.7 1.1 2.8 -1.2 0.6 -0.3 1.4 -1.7 -0.6 -0.9
Medication: Paracetamol 0.7 1.1 3.7 1.9 -0.5 -0.5 0.1 0.2 1.9 0.3
Medication: Lisinopril 0.4 0.5 1.6 -0.4 1.3 -0.2 -0.5 -0.4 1.2 0.4
Medication: Atorvastatin 0.8 1.0 3.8 0.8 0.2 0.5 -0.6 -0.0 1.9 1.5
Illnesses of father: High blood pressure 0.7 0.9 2.3 0.8 0.3 0.4 -1.1 0.8 1.5 0.9
Alcohol drinker status: Never 0.8 0.9 3.4 1.8 0.3 0.5 -0.8 1.1 0.1 1.0
Ever smoked 1.8 3.2 6.8 -0.2 -1.5 -2.1 2.6 -2.3 -0.7 -1.9
Basal metabolic rate 2.1 11.6 27.0 -1.1 -3.7 -1.6 5.2 -3.3 -2.4 -4.5
Leg fat percentage (left) 2.2 8.1 17.6 -2.6 -1.1 -2.2 3.7 -2.8 -2.2 -4.2
Arm fat-free mass (left) 2.8 14.3 30.4 -1.1 -4.0 -1.9 5.5 -3.6 -3.1 -5.2
Number of operations (self-reported) 0.6 0.9 1.8 0.8 -1.1 -0.8 1.1 -1.3 -0.9 -0.6
Average weekly beer plus cider intake 1.6 2.3 2.9 -1.3 -1.1 -1.6 1.5 -1.5 -1.7 -1.6
Irritability 0.9 1.6 4.2 0.4 -2.0 -1.5 1.2 -0.5 1.0 -1.3
Risk taking 0.1 0.2 0.4 -0.6 0.2 -0.6 0.3 -0.4 0.1 -0.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.5 -0.3 0.1 0.7 0.3 -0.2 -0.2 1.2
Fractured/broken bones in last 5 years 3.5 4.5 7.8 0.1 2.2 2.8 -2.3 2.8 0.2 2.4
Age started oral contraceptive pill 1.7 2.1 4.8 -0.3 2.2 2.0 -1.2 1.5 -0.6 1.3
Diastolic blood pressure, automated reading 1.2 3.6 15.1 -1.6 0.2 -1.0 2.1 -3.9 0.5 -1.2
Ever depressed for a whole week 0.8 1.0 2.5 0.0 0.3 -1.2 0.5 -0.6 -1.6 -1.5
Unable to work because of sickness or disability 0.2 0.2 0.5 -0.7 -0.4 0.2 0.4 -0.7 0.1 0.4
Commuting to job workplace: Cycle 1.1 1.3 5.5 -1.0 1.0 0.9 0.6 -0.0 -2.3 0.5
Myopia 1.4 2.0 8.2 2.9 0.8 0.1 -1.1 1.0 -0.3 1.7
Vascular/heart problems diagnosed by doctor 0.5 1.4 6.4 -0.2 -0.8 1.2 -0.9 2.5 -0.5 0.6
Cholesterol lowering medication 1.6 2.4 10.4 -0.0 -3.2 -1.4 0.9 -1.3 -0.5 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 0.8 0.4 -0.3 0.7 -0.8 -0.7 -0.5
Pain experienced in last month 5.1 8.6 13.5 1.6 2.8 3.3 -3.7 2.7 2.2 3.6
Supplements: Calcium 0.9 1.0 2.4 0.0 1.1 0.6 -1.1 1.6 0.5 1.3
Basal cell carcinoma (self-reported) 0.5 0.6 1.5 0.5 -0.2 1.0 -0.8 -0.2 -1.2 0.8
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.8 1.0 0.6 -0.2 0.2 -1.4 0.1 0.6
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 5.9 0.9 1.3 2.4 -1.6 1.4 0.9 1.3
Heart disease (siblings) 0.2 0.3 0.8 0.9 0.1 -0.7 -0.4 0.4 0.6 -0.0
Alcohol drinker status: Previous 0.3 0.3 0.9 1.0 -0.9 -0.3 -0.0 0.3 0.4 -0.1
Pack years of smoking 1.4 2.1 5.1 0.3 -2.2 -1.0 1.4 -1.3 -1.5 -1.6
Impedance of whole body 2.4 12.2 24.8 1.6 -0.7 1.8 -4.6 3.2 5.0 4.8
Leg fat mass (left) 2.8 10.9 23.2 -2.5 -1.8 -2.4 4.7 -3.1 -2.6 -4.8
Arm predicted mass (left) 2.7 13.9 29.4 -1.3 -4.0 -1.8 5.4 -3.5 -3.0 -5.1