Hub : Genes

KCNK7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.2790	0.0990	4.4e-03	-0.012	NA	0.014	NA	-0.006	0.84000	NA	1.5e-01	NA	0.47000
2	GTEx	Esophagus Gastroesophageal Junction	0.2770	0.0840	3.8e-04	0.008	NA	0.146	NA	0.054	0.16000	NA	5.9e-06	NA	0.00490
3	GTEx	Esophagus Muscularis	0.1730	0.0530	3.3e-05	0.023	NA	0.105	NA	0.059	0.01500	NA	6.5e-07	NA	0.00019
4	GTEx	Skin Sun Exposed Lower leg	0.0680	0.0320	7.4e-03	0.034	NA	-0.001	NA	0.016	0.00073	NA	3.9e-01	NA	0.01600
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0430	0.0247	2.4e-04	0.009	0.013	0.011	NA	0.004	0.02600	0.01200	1.9e-02	NA	0.09800
6	TCGA	Lung Adenocarcinoma	0.0338	0.0222	2.9e-03	0.003	0.022	0.027	NA	0.010	0.12000	0.00110	3.9e-04	NA	0.02100
7	TCGA	Prostate Adenocarcinoma	0.0406	0.0297	1.9e-03	0.023	0.031	0.020	NA	0.022	0.00160	0.00031	3.4e-03	NA	0.00190

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.9	0.9	-0.9	0.3	-0.1	0.2	-0.3
Bipolar Disorder or Schizophrenia	1.5	3.8	8.6	-2.9	-0.3	-2.3	1.9	-1.7	-1.3	-2.0
Depressed Affect (Nagel 2018)	3.0	6.2	12.5	-0.5	-3.5	-3.1	2.8	-2.0	-0.7	-3.0
Depression (Nagel 2018)	1.2	1.9	4.7	-1.4	-1.3	-2.2	1.4	-0.4	-0.5	-1.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.7	2.2	-0.7	-0.4	-0.0	0.1	0.3	0.3
Neuroticism (Nagel 2018)	1.0	2.4	6.4	0.1	-2.4	-2.5	1.3	-0.7	0.0	-1.6
Schizophrenia (2018)	2.3	4.8	9.3	-3.0	-0.9	-2.2	2.3	-2.2	-1.8	-2.4
Schizophrenia vs Biploar Disorder	2.0	2.6	7.4	-2.7	-1.0	-0.2	1.5	-1.5	-1.8	-1.5
Worry (Nagel 2018)	0.3	0.6	2.2	-0.3	-1.5	-1.3	0.4	0.2	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.8	1.0	4.5	0.8	-2.1	-0.3	-0.6	0.7	-0.7	0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.5	-0.7	0.4	0.1	-1.0	0.4	0.1
Alzheimer’s Disease (including proxy)	1.1	1.6	9.4	0.8	-3.1	-0.3	0.1	-0.5	-0.8	-0.2
Crohns Disease (2017)	0.2	0.5	1.9	0.2	1.4	0.5	0.5	0.7	-0.6	0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.5	0.9	-0.3	0.8	0.5	-0.2	0.1
Ulcerative Colitis (UC)	0.1	0.3	0.8	-0.9	0.6	-0.4	0.5	0.2	0.6	0.1
Major Depression (MDD)	1.6	2.0	4.2	-1.9	-0.0	-2.0	0.0	-1.3	-0.5	-2.0
Reaction Time	2.7	5.2	12.8	-3.6	0.6	-1.8	1.9	-2.5	-2.1	-2.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	6.3	2.5	-1.6	0.7	-0.0	0.3	0.8	0.8
Breast Cancer	3.3	7.8	15.1	2.5	1.2	-0.1	-3.9	3.5	3.6	2.6
Ovarian Cancer	0.3	0.4	0.8	-0.1	0.4	-0.3	0.9	-0.3	0.9	-0.8
Prostate Cancer	1.2	1.7	6.7	-0.8	0.0	-0.8	1.3	-1.3	-2.6	-0.9
Age at First Birth	0.1	0.2	0.7	0.4	-0.8	-0.1	-0.2	-0.6	-0.3	0.2
Bipolar Disorder (2011)	0.4	0.4	1.2	1.1	1.0	-0.6	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.9	2.5	7.6	-1.8	-1.1	-2.4	2.8	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.4	0.5	3.3	-0.0	0.4	1.8	-0.5	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.4	1.9	0.1	1.4	0.6	0.2	0.4	-0.3	0.2
Mean Putamen Volume	2.1	2.4	4.7	-2.2	0.0	-1.4	1.9	-1.4	-0.9	-2.0
Fasting Glucose	1.1	1.3	2.5	-0.2	-0.7	-1.4	1.6	-1.6	-0.3	-1.3
HbA1C	0.2	0.2	0.4	0.6	-0.6	-0.3	-0.1	-0.4	0.4	-0.4
HDL Cholesterol	2.1	3.4	13.4	1.9	1.2	2.3	-3.7	0.0	0.0	0.0
LDL Cholesterol	0.9	1.4	3.3	-1.7	-1.8	-1.1	1.6	0.0	0.0	0.0
Lupus	1.6	2.5	5.6	-1.5	-0.3	-1.3	2.0	-2.4	-0.1	-1.9
Neuroticism (2016)	0.4	0.5	1.2	0.5	-0.3	-1.1	0.7	-0.8	0.4	-0.8
Primary Biliary Cirrhosis	2.8	4.0	6.8	-1.7	-1.8	-2.4	2.6	-1.8	-0.7	-2.4
Rheumatoid Arthritis	0.6	0.8	2.7	0.3	-1.6	0.3	0.3	0.2	1.5	0.6
Schizophrenia (2014)	2.2	4.9	9.5	-3.1	-0.7	-1.9	2.7	-2.6	-1.4	-2.2
Triglycerides	1.3	2.2	7.5	-1.3	-2.7	-1.2	2.2	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	3.5	4.1	12.1	-2.7	-1.6	-2.5	3.5	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.4	-0.6	-0.2	-0.4	0.0	0.5	0.6	0.4
Blood Eosinophil Count	4.5	34.9	73.8	5.8	-2.5	-0.4	-7.7	6.1	8.6	5.8
Blood Platelet Count	8.6	99.3	163.8	8.8	1.5	8.6	-11.6	12.8	9.8	12.2
Blood Red Count	2.5	24.0	33.2	-0.7	-5.5	-5.0	5.5	-5.8	-5.2	-4.7
Blood White Count	0.6	4.6	11.0	0.6	-1.5	-0.5	-2.3	3.3	2.8	2.2
Heel T-Score	3.6	28.4	62.4	-1.0	-3.9	-7.9	3.9	-6.9	2.8	-7.0
BMI	2.0	11.5	26.2	-2.2	-1.1	-2.7	4.8	-2.6	-3.4	-5.1
Height	0.8	15.0	66.3	3.4	-8.1	1.3	2.7	-0.5	4.3	0.1
Waist Hip Ratio (WHR)	2.9	13.2	34.5	-2.4	-2.2	-4.1	3.4	-5.9	-0.4	-4.3
Systolic Blood Pressure	2.0	10.2	40.2	-3.0	-0.3	-1.3	3.1	-6.3	-1.0	-3.1
Smoking Status	3.1	7.5	17.8	-0.8	-1.8	-2.9	4.2	-3.1	-1.6	-3.1
Allergy or Eczema	1.4	3.7	15.9	1.0	-1.5	-4.0	-1.1	0.4	2.2	-0.7
Cardiovascular Disease	1.3	4.2	13.2	-1.0	0.1	-2.7	1.9	-3.6	-0.4	-2.1
Hypothyroidism (self reported)	1.7	3.8	12.1	2.4	-3.5	-1.2	-1.1	1.1	2.2	0.1
Respiratory disease	1.1	2.4	9.4	0.7	-1.5	-3.1	-0.2	0.1	1.3	-1.8
Type 2 Diabetes (T2D) (2018)	7.6	14.2	28.9	-2.7	-1.0	-3.8	3.8	-4.9	-3.1	-5.4
Lung FEV1/FVC ratio	0.6	2.8	12.3	-0.1	3.5	1.6	0.6	-1.4	-1.4	0.6
Lung FVC	1.8	8.9	21.2	-2.1	-4.6	-3.1	3.0	-3.1	-0.2	-3.0
Neuroticism	1.1	2.6	8.5	0.8	-2.9	-2.5	1.1	-0.1	0.5	-1.0
Chronotype (morning person)	0.9	2.0	3.4	0.1	-0.6	1.6	-1.5	1.7	1.8	1.6
Hair Pigment	0.7	20.6	44.0	2.4	3.1	6.2	-4.1	6.6	0.9	5.4
Tanning	0.1	1.0	2.6	-1.6	-0.2	-1.3	0.8	-0.2	-1.1	-0.7
Hand grip strength (left)	0.8	2.1	11.8	0.8	-3.4	0.2	1.4	0.2	0.2	-0.6
Number of treatments/medications taken	0.6	1.0	4.2	0.5	0.6	-1.3	0.2	-0.8	2.0	-0.3
Average weekly spirits intake	0.7	0.8	2.6	-0.5	1.6	0.8	1.1	-0.3	0.1	-1.0
Sensitivity / hurt feelings	0.9	1.5	3.1	0.7	-1.0	1.1	-0.6	1.8	1.4	1.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.4	-1.9	-1.1	-1.7	1.7	-0.8	-0.7	-1.4
Hearing difficulty/problems: Yes	0.5	0.7	2.0	0.5	1.4	-0.5	-1.1	1.0	0.7	0.4
Relative age of first facial hair	1.5	3.1	9.8	-0.2	2.5	3.1	-0.9	1.6	-0.9	1.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.8	-0.7	0.1	-0.8	1.6	-1.7	-0.9	-1.3
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.9	1.6	0.9	0.2	-1.4	2.0	2.2	1.0
Ever had hysterectomy (womb removed)	0.6	0.6	1.6	0.1	1.2	1.3	0.0	0.1	0.7	0.8
Systolic blood pressure, automated reading	2.6	7.5	23.3	-2.7	-0.4	-1.3	3.1	-4.8	-1.1	-3.1
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	6.3	-1.0	-0.9	-2.4	1.9	-1.5	-0.2	-2.5
Angina	0.2	0.2	1.0	0.6	-0.0	0.0	-0.1	-0.5	0.2	1.0
Medication for hormone replacement therapy	1.3	1.4	3.5	0.9	0.2	1.3	-1.2	1.3	1.9	1.1
Vitamin and mineral supplements	0.6	0.8	2.7	0.4	-0.2	1.6	-1.2	0.5	-0.5	0.8
Supplements: Zinc	0.2	0.2	1.0	-0.2	-0.3	-0.3	0.4	0.2	-1.0	-0.3
Medication: Co-codamol	2.8	3.2	5.7	-2.4	-0.7	-1.0	2.2	-2.1	-2.0	-1.4
Medication: Metformin	4.4	6.2	12.2	-2.4	-0.7	-2.1	2.2	-3.2	-2.3	-3.5
Diabetes (father)	7.5	9.3	13.5	-3.5	-0.0	-3.2	3.2	-3.2	-3.0	-3.7
Diabetes (mother)	3.2	4.1	8.8	-0.7	-1.5	-2.6	1.9	-2.5	-0.6	-3.0
Severe depression (siblings)	0.5	0.6	1.7	1.3	1.3	-0.2	-0.3	0.8	-0.2	-0.0
Pack years adult smoking proportion	1.6	2.4	7.0	0.1	-2.6	-1.1	1.4	-1.2	-1.6	-1.6
Impedance of leg (right)	1.4	6.9	18.8	1.0	-1.8	1.3	-3.2	1.9	4.3	3.1
Leg fat-free mass (left)	1.4	7.2	19.3	-1.0	-2.6	-1.1	4.4	-2.4	-1.9	-3.6
Trunk fat percentage	0.7	3.0	6.8	-1.5	-1.1	-1.5	2.6	-1.4	-0.2	-2.5
Hand grip strength (right)	1.2	3.4	14.9	0.4	-3.9	-1.1	1.9	-0.9	0.6	-1.5
Townsend deprivation index at recruitment	0.9	1.2	2.7	0.3	-1.6	-1.6	0.9	-1.2	0.2	-1.1
Current tobacco smoking	4.0	6.6	12.0	-2.4	-0.9	-1.7	3.5	-2.7	-2.5	-3.2
Average weekly fortified wine intake	2.2	2.6	4.5	1.0	1.3	1.4	-1.3	2.1	1.8	2.0
Maternal smoking around birth	0.4	0.6	1.8	1.3	-1.3	0.1	0.1	0.7	0.6	0.2
Fed-up feelings	3.3	6.0	16.5	0.6	-4.1	-2.0	3.0	-2.2	-1.1	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.0	4.0	7.2	-1.5	-1.4	-2.7	2.1	-1.5	-1.8	-2.6
Relative age voice broke	1.1	1.7	4.3	-1.4	1.9	2.1	-0.1	0.3	-1.3	0.5
Taking other prescription medications	0.4	0.6	1.3	0.3	0.1	-1.1	0.9	-0.8	0.6	-0.9
Age when periods started (menarche)	5.0	12.1	21.7	1.9	0.2	4.0	-4.0	4.3	3.0	4.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	-0.3	0.4	-0.7	1.4	-1.3	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.3	18.5	-0.4	-3.2	-4.3	2.6	-3.6	1.5	-3.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.1	-0.5	-0.1	0.6	-0.6	-0.4	-0.6
Qualifications: CSEs or equivalent	2.6	3.4	5.2	-2.3	-2.0	-1.3	2.1	-2.2	-1.2	-1.5
Serious illness, injury or assault to yourself	2.7	3.3	6.7	-1.7	0.5	-1.6	2.1	-2.2	-1.2	-2.6
High blood pressure	0.7	1.9	6.9	-0.3	0.8	-1.7	1.2	-2.6	0.3	-1.2
Hayfever, allergic rhinitis or eczema	1.6	3.5	10.1	1.2	-2.4	-3.2	-1.2	0.4	2.3	-0.1
Multivitamins +/- minerals	0.3	0.4	1.1	-0.1	-0.2	-1.0	1.0	-0.6	0.3	-0.6
Stomach or abdominal pain in last month	2.8	3.5	6.5	-1.0	0.1	-1.9	2.5	-2.5	-1.6	-2.3
Supplements: Glucosamine	0.2	0.3	1.2	0.2	0.2	-1.1	0.4	-0.6	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.0	0.2	0.3	-0.5	0.6	-0.4	0.8
Medication: Atenolol	3.0	3.8	6.6	1.6	1.1	2.0	-1.9	1.4	2.6	2.5
Medication: Levothyroxine sodium	1.5	2.6	9.4	1.7	-3.1	-2.0	0.4	0.1	1.1	-0.6
Sitting height	1.6	11.3	29.7	-0.7	-5.5	-2.5	4.2	-3.5	-1.6	-3.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.9	-0.7	0.0	-1.4	0.6	0.0	0.3	-0.7
High blood pressure (mother)	0.7	0.9	1.7	-0.7	1.3	-1.3	0.5	-0.9	0.2	-1.3
Body mass index (BMI)	2.4	10.4	24.0	-2.4	-0.1	-2.4	4.3	-3.0	-3.2	-4.9
Impedance of leg (left)	1.1	5.5	14.0	1.1	-1.9	0.7	-2.8	1.6	3.7	2.9
Leg predicted mass (left)	1.3	6.8	18.5	-0.9	-2.5	-1.0	4.3	-2.3	-1.9	-3.5
Trunk fat mass	1.5	6.4	15.3	-1.7	-2.1	-1.7	3.9	-2.4	-1.1	-3.6
Waist circumference	2.9	10.8	22.5	-2.0	-2.0	-3.0	4.4	-3.8	-1.5	-4.7
Number of incorrect matches in round	3.4	5.6	7.5	1.3	2.1	2.3	-2.4	2.7	2.7	2.7
Past tobacco smoking	2.2	4.0	7.9	0.5	1.3	2.4	-2.8	2.6	0.9	2.1
Alcohol usually taken with meals	0.6	0.9	1.8	1.4	0.7	0.8	-1.1	0.7	1.0	1.0
Nervous feelings	0.5	1.0	1.8	0.6	-1.1	-0.8	-0.8	1.0	1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.9	-0.5	-1.1	-2.6	2.5	-1.2	-1.8	-2.2
Hearing difficulty/problems with background noise	0.4	0.6	1.4	1.1	1.2	-0.6	-1.0	0.4	-0.2	0.3
Hair/balding pattern: Pattern 2	0.7	1.0	2.0	0.1	-1.4	1.0	-0.2	1.3	0.8	1.2
Had menopause	2.3	2.9	8.1	1.0	1.2	0.1	-1.8	2.8	2.1	1.4
Had other major operations	0.7	0.8	2.9	1.7	0.5	0.9	-1.0	0.2	0.5	0.6
Forced vital capacity (FVC)	2.0	7.6	30.2	-0.3	-5.5	-2.0	2.8	-2.6	0.9	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	12.0	-0.7	-2.4	-3.5	2.0	-3.2	1.6	-3.2
Ever unenthusiastic/disinterested for a whole week	2.2	2.6	5.3	-1.4	0.9	-2.3	1.2	-0.9	-1.9	-2.2
Qualifications: None of the above	0.3	0.7	1.8	-1.3	-1.3	-0.0	0.7	-0.7	-0.3	-0.5
Financial difficulties in last 2 years	3.2	4.2	6.7	-0.0	-2.6	-2.2	2.5	-2.1	-1.5	-2.2
Mouth/teeth dental problems	7.8	12.0	20.3	1.7	1.0	4.5	-4.0	3.5	3.7	4.2
Heart attack	0.4	0.6	2.4	1.0	0.3	-0.4	0.3	-1.5	-0.1	0.5
Allergy	1.4	3.2	8.0	-1.4	2.0	2.8	1.2	-0.6	-2.5	0.5
Pain all over the body in last month	0.5	0.5	1.6	-1.2	-0.3	0.3	0.6	-1.3	-0.4	-0.3
Diabetes (self-reported)	3.4	5.3	11.0	-1.8	-0.5	-2.7	2.0	-2.8	-1.9	-3.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	8.6	1.3	-2.9	-1.3	-0.5	0.5	1.9	0.9
Medication: Ramipril	1.5	1.9	4.3	-1.3	1.4	-0.4	1.7	-2.1	-0.8	-1.3
Medication: Simvastatin	1.4	2.0	4.1	-1.9	0.1	-1.9	0.9	-2.0	-0.2	-1.4
Fluid intelligence score	0.2	0.4	1.1	1.0	-0.5	0.2	0.1	-0.5	0.8	0.6
Illnesses of siblings	0.4	0.5	1.8	-1.3	0.0	0.9	-0.0	0.5	-0.6	0.5
Neuroticism score	1.3	2.8	9.4	0.3	-3.1	-2.3	1.7	-0.7	0.0	-1.2
Weight	2.4	11.8	26.5	-1.7	-3.0	-2.1	5.2	-3.4	-2.2	-4.9
Impedance of arm (right)	4.9	22.8	42.5	2.7	0.3	2.6	-6.3	5.0	6.2	6.5
Arm fat percentage (right)	0.9	3.7	8.9	-1.7	0.2	-1.9	2.3	-1.6	-1.4	-3.0
Trunk fat-free mass	2.0	11.2	24.2	-0.5	-4.2	-1.4	4.9	-3.1	-2.4	-4.3
Hip circumference	0.5	2.2	7.7	-0.5	-1.8	-0.2	2.8	-0.7	0.0	-1.9
Time employed in main current job	0.3	0.3	1.0	0.2	0.3	-0.3	-0.5	1.0	0.8	0.3
Alcohol intake versus 10 years previously	2.3	3.5	7.7	-1.5	-0.9	-1.9	2.6	-2.8	0.2	-1.8
Father’s age at death	3.8	5.1	9.1	2.8	-0.1	2.1	-2.5	3.0	0.9	2.7
Worrier / anxious feelings	1.0	1.9	4.4	1.6	-1.7	0.1	-0.9	2.1	1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.3	1.0	-2.0	-1.9	2.1	-1.8	-0.1	-1.4
Falls in the last year	2.4	3.3	5.7	0.9	0.6	1.6	-2.4	2.4	2.0	2.0
Hair/balding pattern: Pattern 3	1.0	1.5	3.7	-0.2	0.1	-1.9	0.5	-1.2	-1.9	-1.0
Number of live births	0.3	0.4	1.4	1.2	0.1	0.1	-0.7	0.5	-0.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	8.6	-0.2	-2.9	-1.1	1.9	-2.1	0.3	-0.8
Pulse rate	1.5	2.6	10.2	-0.5	3.2	0.6	-1.3	1.8	0.3	1.4
Happiness	1.3	1.6	3.1	0.7	-0.4	-1.8	1.1	-1.5	-1.5	-1.4
Noisy workplace	0.5	0.6	1.4	-0.6	1.1	1.2	-0.1	0.7	0.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.9	2.0	9.6	1.9	3.1	-0.2	-0.1	0.1	-0.5	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.1	0.5	-0.2	-0.7	0.7	-0.1	0.3
Mouth/teeth dental problems: Dentures	2.1	3.6	9.0	-1.0	-0.8	-1.8	2.4	-2.0	-1.2	-3.0
Asthma	2.0	3.9	16.0	0.6	-2.0	-4.0	0.1	0.0	0.5	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-0.3	-0.3	-0.4	0.6	0.5	0.9	0.5
Medication: Cholesterol lowering	1.3	2.0	4.4	-1.3	2.1	-1.6	0.7	-2.0	0.2	-0.5
Depression (self-reported)	0.5	0.6	2.7	0.1	-0.2	-1.7	0.6	-0.1	0.5	-0.9
Medication: Lansoprazole	0.8	0.9	2.6	-1.0	0.5	0.5	0.8	-1.3	-1.6	-0.3
Prospective memory result	1.2	1.4	2.7	-1.2	0.8	1.5	-1.0	1.3	1.7	0.5
Lung cancer (father)	1.1	1.2	6.2	-0.6	-0.3	0.8	1.1	-0.6	-2.5	-0.0
Illnesses of mother	0.3	0.4	1.1	0.3	-0.6	0.6	-0.4	1.0	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	6.5	-0.5	-2.5	-1.1	1.9	-1.8	-0.5	-0.9
Pulse wave Arterial Stiffness index	0.8	1.0	4.2	0.7	-2.0	-0.6	1.2	-0.5	0.3	0.3
Impedance of arm (left)	4.4	20.4	38.6	2.4	0.5	2.8	-5.8	4.6	6.0	6.2
Arm fat mass (right)	2.0	8.4	19.4	-2.0	-1.0	-2.4	4.0	-2.8	-2.2	-4.4
Trunk predicted mass	2.0	11.3	24.6	-0.5	-4.3	-1.4	5.0	-3.1	-2.4	-4.3
Standing height	0.9	9.0	48.6	1.4	-7.0	0.3	2.5	-1.3	1.9	-0.5
Length of working week for main job	1.1	1.2	3.3	-0.1	-0.4	-1.3	1.8	-0.7	-0.7	-1.6
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.7	0.8	0.7	-0.2	-0.3	-0.2	-0.2
Breastfed as a baby	2.1	2.6	5.2	0.9	0.3	1.2	-2.2	2.2	0.6	2.3
Tense / ‘highly strung’	0.6	1.1	4.3	0.8	-1.0	-2.1	0.2	0.2	1.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	9.4	-1.3	-1.4	-2.4	3.0	-1.9	-2.5	-3.1
Hair/balding pattern: Pattern 4	1.0	2.4	4.4	1.8	0.9	1.9	-2.1	0.9	0.6	1.9
Birth weight of first child	2.3	4.2	8.2	-0.4	-1.4	-2.1	2.4	-1.6	-2.9	-2.4
Peak expiratory flow (PEF)	0.7	1.6	4.6	-1.1	-0.7	-0.5	1.9	-2.1	-0.3	-0.9
Pulse wave reflection index	2.3	2.8	10.4	0.3	-3.2	-1.3	1.8	-1.8	-1.0	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.1	0.2	0.2	-2.0	1.0	-0.6	-1.4	-1.1
Loud music exposure frequency	1.8	2.0	5.5	1.9	-0.6	-0.7	-1.4	1.3	2.3	0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.9	1.6	1.7	-0.5	0.4	0.2	0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	5.7	7.4	10.9	-1.4	-1.0	-3.2	3.1	-2.8	-3.3	-3.3
Blood clot in the leg (DVT)	1.6	2.1	5.9	0.7	1.4	2.4	-1.5	1.4	0.9	1.1
Medication: Paracetamol	1.0	1.6	6.4	2.5	-0.9	-0.2	-0.2	0.6	1.8	0.7
Headache pain in last month	1.3	2.2	9.1	1.5	-3.0	-0.8	-0.1	0.8	1.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	7.2	0.4	-2.7	0.5	-0.4	1.5	-0.3	0.1
Glaucoma (self-reported)	4.1	4.9	11.5	1.8	0.0	1.9	-3.4	2.3	1.9	2.6
Gout (self-reported)	1.8	2.4	6.6	2.6	-1.2	-0.9	-0.5	0.1	2.5	1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	7.8	2.0	-2.8	-1.7	-0.3	0.2	1.5	-0.6
Medication: Amlodipine	0.5	0.7	2.9	1.7	-0.2	0.2	-0.8	-0.4	0.8	0.6
Medication: Ventolin 100micrograms inhaler	1.8	2.3	10.6	0.3	-1.5	-3.2	0.2	0.7	0.3	-1.6
Birth weight	4.4	9.5	19.4	-3.2	-0.1	-2.2	3.9	-1.7	-3.7	-4.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.3	-0.5	0.3	0.3	0.7	0.2	0.7
High blood pressure (siblings)	1.2	1.7	4.5	-0.3	0.1	-1.3	1.7	-2.1	-0.2	-1.6
Forced vital capacity (FVC), Best measure	2.3	8.5	28.3	-0.7	-5.3	-2.8	3.0	-2.7	-0.3	-2.5
Body fat percentage	1.2	4.8	10.6	-2.1	-1.0	-1.9	3.0	-2.0	-0.9	-3.3
Leg fat percentage (right)	2.1	7.5	17.3	-2.8	-1.1	-1.9	3.5	-2.6	-2.0	-4.2
Arm fat-free mass (right)	3.4	17.4	39.3	-1.8	-4.0	-1.9	6.3	-4.1	-3.4	-5.6
Exposure to tobacco smoke outside home	0.7	1.0	2.2	0.6	-1.1	-1.5	0.3	0.1	1.1	-1.3
Comparative body size at age 10	3.1	8.5	19.7	-2.5	1.6	-2.0	3.4	-1.4	-4.4	-3.6
Number of full brothers	0.4	0.5	1.7	-0.0	-1.3	-0.1	0.4	-0.8	-0.6	-0.8
Worry too long after embarrassment	0.4	0.6	2.7	0.8	-1.6	-0.7	0.1	0.2	-0.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	0.8	0.4	-0.4	-0.3	1.0	1.2	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	4.6	-0.4	-0.4	-2.1	0.2	-0.3	-0.2	-1.8
Number of children fathered	3.5	3.9	8.4	-0.9	-2.5	-2.2	2.9	-1.4	-1.1	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.0	1.1	-0.7	-0.8	1.0	0.3	0.3
Age at first live birth	2.7	4.7	10.2	1.4	0.0	3.2	-2.3	1.9	2.2	2.7
Pulse wave peak to peak time	0.5	0.6	1.7	-0.5	1.3	0.7	-1.2	0.7	0.0	-0.1
Health satisfaction	3.9	5.0	10.2	-3.2	0.6	-1.9	2.3	-1.9	-2.1	-2.7
Shortness of breath walking on level ground	1.0	1.2	4.4	-1.0	-0.5	-0.5	0.6	-0.9	-2.1	-1.1
Qualifications: College or University degree	2.3	7.2	12.8	2.0	3.0	3.2	-3.1	1.7	1.0	3.6
Eye problems/disorders: None of the above	2.2	2.6	8.1	-2.9	0.4	-0.9	1.5	-0.8	-1.6	-1.8
Mouth/teeth dental problems: Loose teeth	2.6	3.1	4.9	0.2	-1.8	-1.9	1.6	-2.2	-1.6	-2.1
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.3	0.4	0.9	-0.4	-0.5	0.2	0.3
Medication for pain relief, constipation, heartburn	0.7	1.1	3.2	-1.8	0.8	1.5	-0.9	0.6	-0.7	0.3
Neck or shoulder pain in last month	3.4	4.9	8.9	-1.1	-0.6	-3.0	2.8	-2.2	-1.5	-2.9
Medication: Blood pressure	1.0	1.7	9.9	0.5	3.1	0.1	-0.1	-0.9	0.9	0.3
Angina (self-reported)	0.2	0.3	1.0	0.7	-0.1	-0.1	-0.0	-0.7	0.3	1.0
Migraine (self-reported)	0.2	0.2	0.7	0.8	-0.4	-0.0	0.1	0.2	-0.5	-0.5
Medication: Ibuprofen	0.5	0.6	3.0	-0.2	-0.1	0.1	0.0	0.8	1.7	0.9
Medication: Allopurinol	2.1	2.8	8.7	2.5	-1.4	-0.2	-0.7	0.3	3.0	1.5
Medication: Omeprazole	0.5	0.6	1.3	0.4	0.1	-0.5	0.8	-1.1	-1.1	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.8	-1.3	0.0	0.1	-0.0	0.7	1.1	0.1
Mean time to correctly identify matches	1.7	3.2	6.7	-2.6	0.7	-1.4	1.4	-1.9	-2.3	-1.7
Heart disease (mother)	0.4	0.5	1.5	0.6	0.3	0.5	-0.8	-0.1	1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.3	-1.5	1.2	-0.7	0.8	-1.2	-1.2	-0.3
Whole body fat mass	2.1	8.8	19.0	-2.4	-2.0	-2.1	4.4	-2.9	-1.6	-4.2
Leg fat mass (right)	2.8	10.7	23.3	-2.6	-1.8	-2.2	4.6	-3.1	-2.5	-4.8
Arm predicted mass (right)	3.2	16.3	37.1	-1.8	-4.1	-1.8	6.1	-3.9	-3.3	-5.3
Pulse rate, automated reading	3.0	9.6	15.1	1.0	3.1	3.5	-3.6	3.7	1.5	3.9
Alcohol intake frequency.	0.5	1.2	2.6	0.9	-1.2	-0.5	1.6	-1.4	0.2	-1.2
Comparative height size at age 10	0.5	2.9	15.5	0.4	-3.9	0.7	1.8	-0.2	0.9	0.4
Number of full sisters	0.5	0.6	1.6	0.5	-0.3	0.3	-1.3	0.8	1.2	0.5
Suffer from ‘nerves’	0.5	0.7	2.2	-0.2	-1.2	-1.5	0.3	-0.6	-1.1	0.0
Overall health rating	4.6	9.9	16.6	-3.1	-1.4	-3.3	4.0	-3.5	-1.4	-4.1
Chest pain or discomfort	2.3	3.4	7.2	-0.8	-0.9	-2.3	1.9	-2.7	-0.7	-2.4
Had major operations	1.6	1.9	4.9	-0.3	-1.4	-2.2	1.5	-1.3	-0.9	-1.1
Age at last live birth	1.2	1.7	3.2	1.8	-0.1	1.4	-1.4	1.1	0.5	1.8
Family relationship satisfaction	3.3	4.0	6.8	-1.2	1.2	-2.4	1.6	-1.9	-2.6	-2.6
Leg pain on walking	4.2	5.3	7.5	-2.7	-1.2	-2.7	2.3	-2.6	-1.5	-2.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	-2.0	1.3	-0.6	0.6	-0.0	0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.2	-0.0	0.4	-0.2	0.2	0.0	0.1	-0.1
Illness, injury, bereavement, stress in last 2 years	1.8	2.1	7.6	0.3	2.8	1.7	-1.3	1.2	0.2	1.2
Medication: Aspirin	0.5	0.7	2.5	1.6	0.9	-0.2	0.1	-1.0	0.5	-0.0
Supplements: Vitamin C	0.6	0.7	2.8	0.3	-1.7	-1.2	0.6	0.1	0.4	-0.1
Knee pain experienced in last month	3.2	5.0	9.8	-1.5	-1.9	-2.2	3.1	-2.3	-1.6	-2.6
Hypertension (Self-reported)	0.5	1.4	4.6	0.3	0.8	-1.4	0.8	-2.1	1.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	4.2	0.8	-0.8	0.1	1.2	-0.9	-2.1	-0.5
Illnesses of father: Heart disease	0.2	0.3	1.0	0.6	0.3	-0.6	-1.0	0.2	0.8	0.2
Illnesses of siblings: Diabetes	1.4	1.8	3.1	0.0	-1.7	-1.7	1.2	-1.4	0.0	-1.8
Smoking status: Previous	1.7	2.5	5.1	0.2	-0.6	-2.2	2.1	-2.2	-0.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.9	1.2	-2.4	-0.7	0.8	-0.7	0.3	-0.3
Whole body fat-free mass	1.9	10.6	25.4	-0.9	-3.6	-1.3	5.0	-3.1	-2.5	-4.2
Leg fat-free mass (right)	1.4	7.3	19.7	-0.7	-2.6	-1.3	4.4	-2.5	-2.0	-3.5
Arm fat percentage (left)	1.0	4.0	9.8	-1.9	0.2	-1.8	2.5	-1.7	-1.4	-3.1
Average weekly red wine intake	0.8	1.1	2.9	-0.8	0.0	-0.7	0.5	-1.5	-1.7	-1.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.4	1.9	0.2	-0.6	-1.2	2.1	0.6	1.3
Mood swings	2.6	4.6	8.4	-0.4	-2.9	-2.5	2.6	-1.7	-0.6	-2.7
Loneliness, isolation	2.1	2.9	6.8	0.4	-2.4	-2.6	1.2	-1.1	-1.2	-2.0
Long-standing illness, disability or infirmity	2.2	3.4	7.8	-2.8	0.0	-0.9	2.2	-2.3	-0.2	-2.3
Ever had bowel cancer screening	0.3	0.4	1.2	-0.2	1.0	1.1	-0.1	-0.5	-0.2	0.3
Diabetes diagnosed by doctor	4.4	7.3	16.2	-2.0	-0.5	-3.1	2.4	-3.2	-2.1	-4.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	4.6	1.3	-2.1	0.0	-0.2	0.5	-0.1	0.7
Friendships satisfaction	0.8	0.9	3.8	0.1	0.1	-2.0	-0.1	-0.4	-1.0	-1.2
Qualifications: nursing, teaching	1.6	2.5	7.2	2.7	0.3	1.8	-1.8	1.2	0.5	1.5
Commuting to job workplace: Walk	2.7	2.9	5.7	1.7	1.4	1.0	-2.4	1.7	1.4	1.9
Eye problems/disorders: Cataract	1.4	1.6	9.2	3.0	0.3	0.5	-0.6	-0.0	0.9	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.8	0.4	-0.4	-1.7	-0.4	0.0	-0.9	0.7
Medication for cholesterol	0.8	1.2	2.9	-0.4	1.7	1.1	-0.4	1.6	-0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.6	0.8	-1.6	-0.6	-0.2	0.2	0.9	0.7
Back pain experienced in last month	1.7	2.4	4.7	-0.7	-2.2	-1.7	2.1	-1.4	-0.2	-1.6
Mineral and other dietary supplements	1.3	1.7	6.5	-1.4	-0.4	0.2	1.0	-0.7	-2.5	-1.4
Breast cancer (self-reported)	3.3	4.0	17.2	-0.2	0.8	4.1	-1.3	2.0	1.3	1.6
Asthma (self-reported)	1.6	3.2	13.2	0.7	-1.8	-3.6	-0.2	0.5	1.1	-2.0
Osteoporosis (self-reported)	2.4	3.0	9.3	-0.7	1.7	3.1	-1.6	1.8	0.6	1.4
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.1	0.3	-0.6	0.7	-0.1	0.6	-0.1
Medication: Aspirin	1.0	1.3	4.0	2.0	1.4	0.2	-0.6	-0.3	1.3	0.8
Medication: Gliclazide	2.9	3.3	6.3	-2.2	1.7	-1.5	1.7	-1.6	-0.9	-2.5
Illnesses of father: None of the above (group 1)	1.3	1.7	4.3	1.4	-0.2	2.1	-0.8	1.6	-0.3	1.4
Smoking status: Current	3.9	6.2	11.5	-2.4	-0.8	-1.6	3.4	-2.7	-2.6	-3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.7	-1.6	0.3	0.2	0.5	-0.7	-0.2	-0.0
Whole body water mass	2.0	11.4	27.0	-0.9	-3.7	-1.3	5.2	-3.2	-2.6	-4.4
Leg predicted mass (right)	1.3	7.1	19.1	-0.7	-2.6	-1.3	4.4	-2.4	-2.1	-3.5
Arm fat mass (left)	1.9	7.6	17.9	-2.0	-1.2	-2.1	3.9	-2.5	-2.1	-4.2
Number of self-reported non-cancer illnesses	0.5	0.8	1.7	1.3	0.2	-1.3	-0.1	-0.9	1.2	-0.4
Average weekly champagne plus white wine intake	2.8	3.8	5.4	2.3	0.5	1.8	-2.1	2.1	2.3	2.1
Miserableness	1.9	3.2	6.1	0.2	-2.4	-2.5	1.9	-1.9	-0.4	-1.8
Guilty feelings	0.4	0.7	2.8	0.7	-0.7	-1.7	0.5	-0.1	0.7	-0.2
Wears glasses or contact lenses	0.7	0.8	2.8	-0.1	1.2	0.9	-0.6	1.7	-0.0	0.7
Ever taken oral contraceptive pill	0.8	0.8	2.2	1.0	-1.1	-1.5	0.5	-0.7	-0.5	-0.6
Hearing aid user	2.1	2.4	5.0	0.4	1.1	1.8	-1.5	1.9	1.1	2.2
Mother’s age at death	0.3	0.4	0.9	-0.1	-0.2	0.9	-0.7	0.7	-0.7	0.7
Financial situation satisfaction	1.4	1.7	2.5	-1.0	0.5	-1.4	1.6	-1.4	-1.3	-1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	1.2	0.4	0.5	-0.8	1.1	-0.1	0.6
Commuting to job workplace: Public transport	0.4	0.5	2.0	0.2	-0.8	-1.4	-0.0	-0.6	0.3	-0.4
Eye problems/disorders: Glaucoma	4.3	5.1	10.8	1.7	0.2	1.5	-3.3	1.9	2.8	2.9
Medication: Blood pressure	1.2	2.3	8.4	0.3	-1.7	-1.4	1.2	-2.9	0.8	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.2	0.4	-1.0	-0.6	1.5	-1.3	-0.1	-0.8
Supplements: Fish oil (including cod liver oil)	2.0	2.6	7.0	1.9	1.1	-0.1	-1.4	1.1	2.6	1.7
High cholesterol (Self-reported)	0.3	0.5	1.8	0.9	-0.7	-1.4	0.0	-0.5	-0.2	-0.5
Medication: Bendroflumethiazide	0.7	1.1	2.8	-1.2	0.6	-0.3	1.4	-1.7	-0.6	-0.9
Medication: Paracetamol	0.7	1.1	3.7	1.9	-0.5	-0.5	0.1	0.2	1.9	0.3
Medication: Lisinopril	0.4	0.5	1.6	-0.4	1.3	-0.2	-0.5	-0.4	1.2	0.4
Medication: Atorvastatin	0.8	1.0	3.8	0.8	0.2	0.5	-0.6	-0.0	1.9	1.5
Illnesses of father: High blood pressure	0.7	0.9	2.3	0.8	0.3	0.4	-1.1	0.8	1.5	0.9
Alcohol drinker status: Never	0.8	0.9	3.4	1.8	0.3	0.5	-0.8	1.1	0.1	1.0
Ever smoked	1.8	3.2	6.8	-0.2	-1.5	-2.1	2.6	-2.3	-0.7	-1.9
Basal metabolic rate	2.1	11.6	27.0	-1.1	-3.7	-1.6	5.2	-3.3	-2.4	-4.5
Leg fat percentage (left)	2.2	8.1	17.6	-2.6	-1.1	-2.2	3.7	-2.8	-2.2	-4.2
Arm fat-free mass (left)	2.8	14.3	30.4	-1.1	-4.0	-1.9	5.5	-3.6	-3.1	-5.2
Number of operations (self-reported)	0.6	0.9	1.8	0.8	-1.1	-0.8	1.1	-1.3	-0.9	-0.6
Average weekly beer plus cider intake	1.6	2.3	2.9	-1.3	-1.1	-1.6	1.5	-1.5	-1.7	-1.6
Irritability	0.9	1.6	4.2	0.4	-2.0	-1.5	1.2	-0.5	1.0	-1.3
Risk taking	0.1	0.2	0.4	-0.6	0.2	-0.6	0.3	-0.4	0.1	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.5	-0.3	0.1	0.7	0.3	-0.2	-0.2	1.2
Fractured/broken bones in last 5 years	3.5	4.5	7.8	0.1	2.2	2.8	-2.3	2.8	0.2	2.4
Age started oral contraceptive pill	1.7	2.1	4.8	-0.3	2.2	2.0	-1.2	1.5	-0.6	1.3
Diastolic blood pressure, automated reading	1.2	3.6	15.1	-1.6	0.2	-1.0	2.1	-3.9	0.5	-1.2
Ever depressed for a whole week	0.8	1.0	2.5	0.0	0.3	-1.2	0.5	-0.6	-1.6	-1.5
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.7	-0.4	0.2	0.4	-0.7	0.1	0.4
Commuting to job workplace: Cycle	1.1	1.3	5.5	-1.0	1.0	0.9	0.6	-0.0	-2.3	0.5
Myopia	1.4	2.0	8.2	2.9	0.8	0.1	-1.1	1.0	-0.3	1.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	6.4	-0.2	-0.8	1.2	-0.9	2.5	-0.5	0.6
Cholesterol lowering medication	1.6	2.4	10.4	-0.0	-3.2	-1.4	0.9	-1.3	-0.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.8	0.4	-0.3	0.7	-0.8	-0.7	-0.5
Pain experienced in last month	5.1	8.6	13.5	1.6	2.8	3.3	-3.7	2.7	2.2	3.6
Supplements: Calcium	0.9	1.0	2.4	0.0	1.1	0.6	-1.1	1.6	0.5	1.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	0.5	-0.2	1.0	-0.8	-0.2	-1.2	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	1.0	0.6	-0.2	0.2	-1.4	0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.9	0.9	1.3	2.4	-1.6	1.4	0.9	1.3
Heart disease (siblings)	0.2	0.3	0.8	0.9	0.1	-0.7	-0.4	0.4	0.6	-0.0
Alcohol drinker status: Previous	0.3	0.3	0.9	1.0	-0.9	-0.3	-0.0	0.3	0.4	-0.1
Pack years of smoking	1.4	2.1	5.1	0.3	-2.2	-1.0	1.4	-1.3	-1.5	-1.6
Impedance of whole body	2.4	12.2	24.8	1.6	-0.7	1.8	-4.6	3.2	5.0	4.8
Leg fat mass (left)	2.8	10.9	23.2	-2.5	-1.8	-2.4	4.7	-3.1	-2.6	-4.8
Arm predicted mass (left)	2.7	13.9	29.4	-1.3	-4.0	-1.8	5.4	-3.5	-3.0	-5.1