Best TWAS P=3.95e-13 · Best GWAS P=7.13e-12 conditioned to 0.148
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PTPRJ | 0.05 | 0.05 | lasso | 2 | 0.04 | 3.9e-04 | 6.4 | 6.2 | 7.0e-10 | 0.59 | 0.01 | 0.97 | FALSE |
2 | GTEx | Artery Aorta | MADD | 0.09 | 0.03 | enet | 22 | 0.04 | 1.9e-03 | -5.0 | 5.9 | 4.3e-09 | 0.45 | 0.09 | 0.39 | FALSE |
3 | GTEx | Artery Aorta | PACSIN3 | 0.10 | 0.04 | lasso | 4 | 0.03 | 1.1e-02 | 3.9 | 6.1 | 1.2e-09 | 0.45 | 0.11 | 0.72 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | PSMC3 | 0.02 | 0.01 | lasso | 1 | 0.04 | 2.5e-02 | 5.6 | -5.6 | 2.3e-08 | -0.72 | 0.02 | 0.20 | FALSE |
5 | GTEx | Esophagus Mucosa | PACSIN3 | 0.24 | 0.19 | lasso | 8 | 0.21 | 7.5e-14 | 4.1 | 5.2 | 1.5e-07 | 0.38 | 0.88 | 0.12 | FALSE |
6 | GTEx | Lung | PSMC3 | 0.07 | 0.02 | lasso | 2 | 0.03 | 3.6e-03 | 5.4 | -5.5 | 4.8e-08 | -0.46 | 0.06 | 0.68 | FALSE |
7 | GTEx | Muscle Skeletal | SLC39A13 | 0.05 | 0.01 | lasso | 3 | 0.01 | 8.5e-02 | 5.4 | -5.9 | 3.4e-09 | -0.59 | 0.04 | 0.60 | FALSE |
8 | GTEx | Prostate | PSMC3 | 0.21 | 0.10 | lasso | 6 | 0.20 | 7.9e-06 | 5.4 | -6.5 | 8.1e-11 | -0.56 | 0.05 | 0.67 | FALSE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | LRP4 | 0.13 | 0.00 | lasso | 7 | 0.02 | 3.5e-02 | 5.3 | 6.2 | 6.0e-10 | 0.53 | 0.07 | 0.50 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | PSMC3 | 0.20 | 0.05 | lasso | 7 | 0.10 | 1.2e-08 | 5.6 | -5.5 | 3.5e-08 | -0.68 | 0.06 | 0.94 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | ARHGAP1 | 0.08 | 0.01 | lasso | 5 | 0.02 | 1.4e-02 | 4.7 | -5.2 | 2.5e-07 | -0.29 | 0.02 | 0.89 | FALSE |
12 | METSIM | Adipose | RAPSN | 0.11 | 0.01 | enet | 21 | 0.06 | 7.9e-09 | 3.7 | 5.9 | 3.8e-09 | 0.41 | 0.79 | 0.20 | FALSE |
13 | NTR | Blood | MADD | 0.01 | 0.01 | enet | 8 | 0.01 | 4.7e-03 | 5.5 | 6.0 | 1.5e-09 | 0.31 | 0.05 | 0.70 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | CELF1 | 0.03 | 0.01 | bslmm | 289 | 0.01 | 2.9e-02 | 6.0 | 7.3 | 3.9e-13 | 0.83 | 0.02 | 0.87 | TRUE |
15 | ROSMAP | Brain Pre-frontal Cortex | PSMC3 | 0.15 | 0.08 | bslmm | 285 | 0.10 | 5.1e-13 | 5.3 | -5.6 | 1.9e-08 | -0.54 | 0.06 | 0.94 | FALSE |
16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC39A13 | 0.06 | 0.01 | blup | 58 | 0.04 | 9.3e-04 | 4.9 | -5.8 | 6.2e-09 | -0.56 | 0.01 | 0.70 | FALSE |