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chr20:19,318,837-21,919,054

Best TWAS P=1.78e-15 · Best GWAS P=6.27e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C20orf26	0.20	0.17	lasso	6	0.18	4.9e-21	-5.6	5.5	5.1e-08	-0.06	0.10	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	INSM1	0.07	0.00	bslmm	522	0.02	2.2e-03	4.0	5.8	6.2e-09	-0.01	0.09	0.12	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PLK1S1	0.08	0.01	lasso	3	0.04	1.1e-05	7.0	6.5	9.2e-11	0.82	0.02	0.98	FALSE
4	GTEx	Artery Tibial	PLK1S1	0.07	0.08	enet	10	0.08	4.0e-07	8.3	8.0	1.8e-15	0.97	0.01	0.99	TRUE
5	GTEx	Esophagus Mucosa	PLK1S1	0.11	0.11	lasso	5	0.09	7.8e-07	6.4	6.4	1.7e-10	0.83	0.12	0.88	FALSE
6	GTEx	Heart Atrial Appendage	PLK1S1	0.15	-0.01	lasso	4	0.00	6.1e-01	1.3	5.8	8.4e-09	0.56	0.05	0.41	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	PLK1S1	0.21	0.09	lasso	6	0.12	5.3e-07	7.9	6.9	4.9e-12	0.93	0.07	0.93	FALSE
8	GTEx	Skin Sun Exposed Lower leg	PLK1S1	0.15	0.13	enet	10	0.15	3.9e-12	6.4	6.0	1.7e-09	0.83	0.90	0.10	FALSE
9	GTEx	Testis	PLK1S1	0.64	0.34	enet	33	0.39	1.0e-18	6.4	7.0	2.5e-12	0.79	0.68	0.32	FALSE
10	GTEx	Whole Blood	PLK1S1	0.08	0.04	enet	9	0.02	4.0e-03	6.4	7.1	1.1e-12	0.89	0.06	0.93	FALSE
11	YFS	Blood	CRNKL1	0.21	0.25	enet	18	0.27	2.3e-89	-5.6	-5.3	1.3e-07	0.03	0.08	0.92	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLK1S1	0.05	0.07	enet	9	0.07	5.5e-15	6.2	6.8	8.5e-12	0.88	0.15	0.85	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	PLK1S1	0.04	0.03	blup	64	0.04	4.0e-05	6.4	7.5	9.7e-14	0.88	0.12	0.88	FALSE
14	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PLK1S1	0.09	0.02	blup	64	0.05	3.1e-03	7.0	7.5	4.2e-14	0.78	0.03	0.53	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLK1S1	0.19	0.12	enet	14	0.13	4.3e-13	6.5	6.7	2.6e-11	0.80	0.89	0.11	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	PLK1S1	0.06	0.04	lasso	3	0.04	1.5e-04	6.5	6.7	2.7e-11	0.85	0.15	0.60	FALSE