Best TWAS P=2.64e-13 · Best GWAS P=2.45e-25 conditioned to 4.57e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIN7B | 0.08 | 0.08 | lasso | 3 | 0.08 | 8.5e-10 | -5.2 | -5.2 | 2.0e-07 | -0.04 | 0.04 | 0.96 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PNKP | 0.15 | 0.16 | enet | 23 | 0.16 | 7.0e-19 | -5.4 | -5.4 | 5.7e-08 | 0.03 | 0.24 | 0.76 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | -5.2 | -6.8 | 8.2e-12 | 0.77 | 0.06 | 0.67 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TBC1D17 | 0.11 | 0.03 | enet | 23 | 0.04 | 6.5e-04 | -4.9 | 6.3 | 3.8e-10 | -0.02 | 0.14 | 0.84 | FALSE |
| 5 | GTEx | Colon Sigmoid | PRR12 | 0.20 | 0.01 | lasso | 8 | 0.00 | 4.9e-01 | 3.5 | 5.7 | 1.2e-08 | 0.02 | 0.04 | 0.30 | FALSE |
| 6 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | -5.4 | -6.6 | 5.2e-11 | -0.01 | 0.02 | 0.98 | TRUE |
| 7 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | -5.2 | 5.2 | 2.2e-07 | -0.05 | 0.37 | 0.63 | FALSE |
| 8 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | -5.6 | -6.5 | 8.0e-11 | 0.02 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | CCDC9 | 0.13 | 0.00 | lasso | 5 | 0.00 | 2.2e-01 | 1.7 | -5.1 | 3.1e-07 | 0.23 | 0.11 | 0.21 | TRUE |
| 10 | GTEx | Skin Sun Exposed Lower leg | AP2A1 | 0.15 | 0.08 | enet | 10 | 0.07 | 1.9e-06 | -5.6 | -5.8 | 8.2e-09 | -0.01 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | 3.6 | 6.1 | 9.6e-10 | 0.00 | 0.05 | 0.40 | FALSE |
| 12 | GTEx | Testis | NTN5 | 0.16 | 0.02 | enet | 23 | 0.06 | 9.6e-04 | -3.2 | -5.9 | 3.2e-09 | -0.02 | 0.03 | 0.76 | TRUE |
| 13 | GTEx | Whole Blood | PNKP | 0.14 | 0.10 | enet | 12 | 0.12 | 1.5e-11 | -5.1 | -5.2 | 2.0e-07 | -0.04 | 0.33 | 0.67 | FALSE |
| 14 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | -5.1 | -7.3 | 2.6e-13 | 0.61 | 0.61 | 0.39 | TRUE |
| 15 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | -8.7 | -6.1 | 1.3e-09 | 0.56 | 0.99 | 0.01 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP2A1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 1.8e-08 | -5.6 | 5.5 | 3.0e-08 | -0.02 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIN7B | 0.02 | 0.00 | enet | 7 | 0.02 | 5.1e-05 | 5.0 | -5.8 | 8.4e-09 | -0.04 | 0.01 | 0.92 | TRUE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | 4.5 | -5.7 | 1.0e-08 | -0.02 | 0.01 | 0.67 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | 4.7 | 6.0 | 1.6e-09 | -0.04 | 0.45 | 0.05 | TRUE |