Best TWAS P=7.75e-11 · Best GWAS P=9.24e-10 conditioned to 0.0146
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FEZ2 | 0.16 | 0.24 | lasso | 2 | 0.22 | 1.3e-26 | 5.9 | -6.0 | 2.6e-09 | -0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 5.4 | 6.0 | 2.7e-09 | 0.87 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 5.4 | -6.2 | 6.8e-10 | -0.86 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | RP11-78I14.1 | 0.10 | 0.08 | enet | 16 | 0.07 | 4.2e-06 | 5.4 | -6.0 | 2.6e-09 | -0.71 | 0.07 | 0.89 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | CRIM1 | 0.36 | 0.21 | lasso | 5 | 0.16 | 5.4e-05 | 5.2 | 5.3 | 8.9e-08 | 0.85 | 0.05 | 0.86 | FALSE |
| 6 | GTEx | Brain Cerebellum | AC007401.1 | 0.27 | 0.21 | enet | 5 | 0.20 | 1.5e-06 | 5.2 | 5.3 | 1.2e-07 | 0.86 | 0.09 | 0.87 | FALSE |
| 7 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 4.9 | 6.5 | 7.8e-11 | 0.66 | 0.04 | 0.89 | TRUE |
| 8 | GTEx | Whole Blood | AC007401.1 | 0.06 | 0.06 | lasso | 5 | 0.05 | 4.6e-05 | 4.8 | 5.1 | 2.8e-07 | 0.89 | 0.13 | 0.83 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | FEZ2 | 0.41 | 0.55 | lasso | 5 | 0.58 | 3.1e-93 | 5.1 | -5.3 | 1.2e-07 | -0.93 | 0.27 | 0.73 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 4.8 | -6.1 | 1.1e-09 | -0.90 | 0.01 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FEZ2 | 0.06 | 0.05 | lasso | 4 | 0.04 | 3.3e-03 | 5.4 | -5.2 | 1.8e-07 | -0.92 | 0.04 | 0.82 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FEZ2 | 0.06 | 0.05 | blup | 87 | 0.08 | 1.4e-08 | 5.1 | -5.6 | 1.9e-08 | -0.91 | 0.08 | 0.92 | FALSE |