[Hub]/) : Traits : Whole body water mass :

chr2:23,453,834-29,344,127

Best TWAS P=5.24e-45 · Best GWAS P=7.1e-42 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 4.784 -7.2 5.8e-13 0.72 0.28 0.72 TRUE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 4.675 7.1 1.2e-12 -0.75 0.48 0.52 FALSE
3 CommonMind Brain Pre-frontal Cortex UBXN2A 0.22 0.18 enet 28 0.24 3.0e-28 -8.374 7.5 8.8e-14 -0.03 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous UBXN2A 0.06 0.04 lasso 5 0.04 5.2e-04 -7.340 -5.6 2.6e-08 -0.07 0.36 0.60 FALSE
5 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 6.218 -6.3 2.2e-10 0.65 0.45 0.27 FALSE
6 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 4.801 -5.4 5.7e-08 0.64 0.11 0.28 FALSE
7 GTEx Adipose Visceral Omentum UBXN2A 0.10 0.08 enet 29 0.03 9.8e-03 -7.376 -5.9 3.0e-09 -0.08 0.13 0.84 FALSE
8 GTEx Adipose Visceral Omentum PFN4 0.08 0.02 enet 14 0.04 3.1e-03 -5.604 -5.2 2.1e-07 0.11 0.10 0.07 FALSE
9 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 5.478 -5.3 1.0e-07 0.60 0.85 0.08 FALSE
10 GTEx Adrenal Gland PFN4 0.20 0.15 lasso 2 0.18 3.9e-07 -5.614 -5.4 7.4e-08 0.09 0.20 0.12 FALSE
11 GTEx Artery Aorta NCOA1 0.15 0.00 enet 15 0.01 1.4e-01 -3.476 -6.1 1.1e-09 -0.01 0.07 0.04 FALSE
12 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 5.478 -5.5 5.2e-08 0.58 0.24 0.14 FALSE
13 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 4.671 -6.2 6.2e-10 0.66 0.29 0.12 FALSE
14 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 5.478 -5.8 5.4e-09 0.62 0.99 0.00 FALSE
15 GTEx Breast Mammary Tissue (Male) NCOA1 0.13 -0.01 lasso 3 0.04 4.8e-02 -4.138 -5.4 6.6e-08 0.09 0.05 0.06 FALSE
16 GTEx Breast Mammary Tissue (Female) AC074117.10 0.06 0.01 lasso 2 0.04 2.7e-02 7.031 7.9 3.9e-15 -0.23 0.04 0.05 TRUE
17 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 4.695 -5.4 8.1e-08 0.62 0.57 0.10 FALSE
18 GTEx Cells EBV-transformed lymphocytes PFN4 0.18 0.13 lasso 12 0.12 8.9e-05 -5.604 -7.1 1.3e-12 0.06 0.17 0.53 FALSE
19 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 5.478 -5.7 1.2e-08 0.61 0.95 0.04 FALSE
20 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 6.218 -5.8 5.7e-09 0.66 0.87 0.13 FALSE
21 GTEx Colon Sigmoid DNMT3A 0.19 -0.01 lasso 8 0.00 4.5e-01 -2.249 -6.5 1.0e-10 0.06 0.07 0.18 TRUE
22 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 5.478 -5.4 8.2e-08 0.60 0.85 0.08 FALSE
23 GTEx Colon Transverse NRBP1 0.08 0.03 enet 14 0.00 2.0e-01 5.446 -5.4 7.7e-08 0.59 0.16 0.14 FALSE
24 GTEx Colon Transverse UBXN2A 0.11 0.01 enet 8 0.03 8.7e-03 -7.362 -7.7 9.9e-15 -0.06 0.06 0.76 FALSE
25 GTEx Colon Transverse PFN4 0.14 0.07 lasso 2 0.04 3.3e-03 -5.576 -5.6 2.2e-08 0.05 0.06 0.48 FALSE
26 GTEx Esophagus Gastroesophageal Junction SF3B14 0.10 0.01 lasso 8 0.00 3.5e-01 -3.095 -5.6 2.6e-08 0.01 0.07 0.38 FALSE
27 GTEx Esophagus Gastroesophageal Junction PFN4 0.13 0.01 lasso 12 0.01 9.7e-02 -7.080 -6.3 2.4e-10 0.08 0.10 0.13 FALSE
28 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 4.840 -6.1 1.0e-09 0.64 0.43 0.30 TRUE
29 GTEx Esophagus Gastroesophageal Junction RP11-373D23.3 0.17 0.01 enet 15 0.04 1.2e-02 4.499 -5.6 2.7e-08 0.28 0.07 0.32 FALSE
30 GTEx Esophagus Mucosa TP53I3 0.16 0.03 enet 23 0.06 8.2e-05 1.539 -7.2 5.3e-13 0.05 0.08 0.36 FALSE
31 GTEx Esophagus Mucosa PFN4 0.16 0.15 lasso 4 0.15 3.6e-10 -5.604 -6.0 2.2e-09 0.05 0.99 0.01 FALSE
32 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 6.218 -8.1 8.2e-16 0.74 0.94 0.06 FALSE
33 GTEx Esophagus Muscularis NCOA1 0.11 0.01 enet 9 0.01 5.8e-02 -3.816 -7.0 3.0e-12 0.01 0.06 0.28 FALSE
34 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 6.218 -8.8 2.2e-18 0.82 0.01 0.97 FALSE
35 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 6.218 -6.4 1.7e-10 0.65 0.73 0.26 FALSE
36 GTEx Heart Atrial Appendage UBXN2A 0.08 0.02 lasso 3 0.02 5.2e-02 -7.445 -8.1 4.4e-16 0.02 0.24 0.24 FALSE
37 GTEx Heart Atrial Appendage PFN4 0.22 0.06 lasso 7 0.10 2.8e-05 1.539 -6.4 1.8e-10 0.12 0.59 0.14 TRUE
38 GTEx Heart Left Ventricle PFN4 0.23 0.28 lasso 6 0.28 4.1e-15 -5.576 -6.9 6.0e-12 0.05 1.00 0.00 FALSE
39 GTEx Lung NCOA1 0.12 0.04 lasso 7 0.06 1.9e-05 -3.760 -6.7 2.0e-11 0.01 0.52 0.02 TRUE
40 GTEx Lung UBXN2A 0.09 0.06 enet 7 0.07 6.1e-06 -0.862 -5.2 2.2e-07 -0.07 0.48 0.51 FALSE
41 GTEx Lung PFN4 0.14 0.12 enet 8 0.15 7.6e-12 -5.604 -5.4 7.9e-08 0.10 1.00 0.00 FALSE
42 GTEx Lung RP11-373D23.3 0.08 0.00 enet 21 0.02 2.3e-02 3.487 -5.6 2.0e-08 0.23 0.16 0.30 FALSE
43 GTEx Muscle Skeletal PFN4 0.12 0.09 lasso 4 0.09 5.6e-09 -5.604 -5.8 7.1e-09 0.07 1.00 0.00 FALSE
44 GTEx Muscle Skeletal GPN1 0.06 0.02 enet 9 0.02 2.9e-03 -2.085 -6.4 1.5e-10 0.43 0.29 0.07 FALSE
45 GTEx Nerve Tibial NRBP1 0.06 0.00 enet 9 0.02 2.0e-02 6.218 -5.7 1.1e-08 0.61 0.28 0.61 FALSE
46 GTEx Nerve Tibial PFN4 0.25 0.16 lasso 5 0.20 3.8e-14 -5.604 -5.6 2.6e-08 0.09 1.00 0.00 FALSE
47 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 4.801 -8.0 1.8e-15 0.77 0.04 0.80 FALSE
48 GTEx Pituitary PFN4 0.34 0.03 lasso 14 0.02 1.1e-01 -5.614 -5.3 1.3e-07 0.05 0.04 0.06 FALSE
49 GTEx Pituitary AC074117.10 0.23 0.23 lasso 8 0.29 5.6e-08 4.131 -5.4 8.4e-08 0.66 0.34 0.57 FALSE
50 GTEx Skin Sun Exposed Lower leg UBXN2A 0.08 0.04 enet 17 0.03 1.3e-03 -7.304 -5.7 1.4e-08 -0.06 0.58 0.33 FALSE
51 GTEx Small Intestine Terminal Ileum UBXN2A 0.18 0.08 enet 33 0.16 2.5e-04 -7.296 -6.2 5.3e-10 -0.08 0.04 0.86 FALSE
52 GTEx Spleen UBXN2A 0.31 0.11 enet 19 0.17 4.1e-05 8.594 -8.8 1.5e-18 -0.05 0.05 0.90 TRUE
53 GTEx Stomach AC074117.10 0.06 0.01 lasso 7 0.01 7.8e-02 6.218 9.2 5.5e-20 -0.36 0.20 0.08 FALSE
54 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 6.218 -8.6 9.9e-18 0.80 0.03 0.96 FALSE
55 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 4.844 -9.4 3.7e-21 0.85 0.05 0.94 FALSE
56 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 8.573 11.7 8.1e-32 -0.69 0.67 0.33 FALSE
57 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 4.840 -5.2 2.1e-07 0.61 1.00 0.00 FALSE
58 GTEx Thyroid RP11-373D23.3 0.16 0.07 enet 19 0.04 2.6e-04 4.380 -6.5 7.6e-11 0.15 0.52 0.12 TRUE
59 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 4.122 -7.2 4.6e-13 0.72 0.08 0.57 FALSE
60 GTEx Whole Blood UBXN2A 0.17 0.07 lasso 8 0.09 2.1e-08 -0.913 -5.9 4.7e-09 -0.08 0.05 0.95 FALSE
61 METSIM Adipose ATRAID 0.11 0.09 bslmm 297 0.10 1.4e-14 2.631 5.2 2.3e-07 -0.47 1.00 0.00 FALSE
62 METSIM Adipose BRE 0.03 0.00 blup 534 0.00 1.3e-01 -0.041 -5.5 4.9e-08 0.30 0.10 0.05 FALSE
63 METSIM Adipose KRTCAP3 0.05 0.01 blup 288 0.03 1.6e-05 4.685 5.7 1.2e-08 -0.52 0.96 0.03 FALSE
64 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 6.218 -6.6 4.9e-11 0.67 1.00 0.00 FALSE
65 METSIM Adipose PREB 0.04 0.01 bslmm 302 0.02 5.6e-04 2.760 5.4 6.3e-08 -0.36 0.07 0.30 FALSE
66 METSIM Adipose SLC35F6 0.04 0.01 blup 362 0.02 1.1e-03 4.025 5.2 1.5e-07 -0.03 0.16 0.12 FALSE
67 METSIM Adipose SLC5A6 0.03 0.02 bslmm 298 0.01 3.9e-03 3.035 -5.9 4.0e-09 0.43 0.25 0.04 FALSE
68 METSIM Adipose UBXN2A 0.07 0.03 bslmm 403 0.06 5.3e-10 -7.304 -6.6 3.8e-11 0.00 0.78 0.21 FALSE
69 NTR Blood ITSN2 0.02 0.00 bslmm 345 0.01 2.9e-03 -3.997 5.7 1.4e-08 0.07 0.05 0.02 FALSE
70 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 5.478 7.7 1.2e-14 -0.63 0.43 0.49 FALSE
71 ROSMAP Brain Pre-frontal Cortex KCNK3 0.24 0.15 lasso 3 0.15 6.5e-19 5.730 -6.2 5.2e-10 0.09 0.00 1.00 TRUE
72 ROSMAP Brain Pre-frontal Cortex UBXN2A 0.03 0.01 lasso 4 0.02 2.2e-03 -7.370 7.6 3.8e-14 -0.04 0.35 0.03 FALSE
73 ROSMAP Brain Pre-frontal Cortex PFN4 0.05 0.03 lasso 1 0.03 1.7e-04 -5.614 -5.6 2.0e-08 0.05 0.37 0.11 FALSE
74 ROSMAP Brain Pre-frontal Cortex FTH1P3 0.04 0.01 bslmm 280 0.02 2.8e-03 6.218 -6.2 6.8e-10 0.65 0.04 0.70 FALSE
75 YFS Blood EIF2B4 0.01 0.00 enet 9 0.00 8.5e-02 2.631 5.8 5.5e-09 -0.52 0.04 0.03 FALSE
76 YFS Blood MRPL33 0.02 0.01 blup 385 0.01 6.4e-05 6.511 -5.9 4.0e-09 0.22 0.97 0.00 FALSE
77 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 4.844 -5.8 4.8e-09 0.61 0.99 0.00 FALSE
78 The Cancer Genome Atlas Bladder Urothelial Carcinoma PFN4 0.11 0.00 enet 8 0.03 9.2e-04 -5.604 -5.3 9.7e-08 0.09 0.00 0.99 FALSE
79 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 4.868 -6.0 2.3e-09 0.66 0.03 0.51 FALSE
80 The Cancer Genome Atlas Breast Invasive Carcinoma FKBP1B 0.04 0.02 blup 41 0.02 3.6e-05 -5.604 6.1 8.1e-10 -0.08 0.43 0.06 FALSE
81 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 -10.598 -9.0 2.7e-19 0.54 0.00 0.99 FALSE
82 The Cancer Genome Atlas Breast Invasive Carcinoma SNX17 0.08 0.01 blup 25 0.02 6.6e-05 3.321 6.8 1.3e-11 -0.55 0.02 0.34 FALSE
83 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PFN4 0.19 0.16 lasso 2 0.15 5.5e-08 -5.604 -5.6 2.1e-08 0.05 0.00 1.00 FALSE
84 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SUPT7L 0.06 0.03 blup 29 0.05 2.0e-03 8.712 6.2 5.4e-10 -0.04 0.04 0.04 TRUE
85 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 6.218 -6.3 3.6e-10 0.67 0.02 0.09 FALSE
86 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PFN4 0.13 0.07 lasso 4 0.06 4.4e-07 -5.604 -5.6 2.3e-08 0.07 0.00 1.00 FALSE
87 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC4A1AP 0.02 0.03 lasso 2 0.03 3.7e-04 -1.590 5.8 7.6e-09 -0.47 0.01 0.83 FALSE
88 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PFN4 0.10 0.07 lasso 2 0.06 1.1e-07 -5.604 -5.6 2.1e-08 0.05 0.00 1.00 FALSE
89 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SUPT7L 0.05 0.02 blup 28 0.04 5.2e-05 8.805 10.9 7.4e-28 -0.40 0.19 0.14 TRUE
90 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 -13.558 14.1 5.2e-45 -0.99 0.00 0.96 TRUE
91 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma NCOA1 0.08 0.07 blup 77 0.05 5.8e-04 2.980 -5.1 3.1e-07 -0.02 0.10 0.63 FALSE
92 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PFN4 0.14 0.02 blup 43 0.03 5.4e-03 -5.614 -5.3 1.3e-07 0.12 0.00 0.94 FALSE
93 The Cancer Genome Atlas Brain Lower Grade Glioma PFN4 0.09 0.07 blup 43 0.08 5.3e-09 -5.614 -5.7 1.1e-08 0.09 0.00 1.00 FALSE
94 The Cancer Genome Atlas Brain Lower Grade Glioma UBXN2A 0.04 0.04 lasso 1 0.03 1.4e-04 -7.384 7.4 1.5e-13 -0.03 0.36 0.14 FALSE
95 The Cancer Genome Atlas Lung Adenocarcinoma PFN4 0.15 0.09 lasso 3 0.09 7.3e-11 -5.614 -5.6 2.0e-08 0.05 0.00 1.00 FALSE
96 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PFN4 0.10 0.07 enet 5 0.08 5.5e-09 -5.614 -5.6 2.8e-08 0.09 0.00 1.00 FALSE
97 The Cancer Genome Atlas Pancreatic Adenocarcinoma PFN4 0.20 0.18 lasso 1 0.16 4.3e-07 -5.576 -5.6 2.5e-08 0.05 0.00 1.00 FALSE
98 The Cancer Genome Atlas Pancreatic Adenocarcinoma POMC 0.22 0.05 blup 37 0.03 2.1e-02 -5.051 -5.8 8.0e-09 0.01 0.00 0.77 TRUE
99 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 4.122 -5.6 2.2e-08 0.64 0.67 0.08 FALSE
100 The Cancer Genome Atlas Prostate Adenocarcinoma PFN4 0.12 0.08 lasso 6 0.07 6.3e-08 -5.604 -5.7 1.2e-08 0.07 0.00 1.00 FALSE
101 The Cancer Genome Atlas Rectum Adenocarcinoma PFN4 0.38 0.11 lasso 5 0.05 2.8e-02 -5.604 -5.6 2.5e-08 0.04 0.00 0.78 FALSE
102 The Cancer Genome Atlas Skin Cutaneous Melanoma SLC4A1AP 0.17 0.05 blup 26 0.08 4.4e-03 -10.598 5.6 2.0e-08 -0.47 0.01 0.72 FALSE
103 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 8.746 11.7 1.6e-31 -0.70 0.41 0.59 FALSE
104 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 8.573 11.0 2.7e-28 -0.64 0.91 0.09 FALSE
105 The Cancer Genome Atlas Thyroid Carcinoma IFT172 0.08 0.01 blup 43 0.02 6.1e-03 9.418 10.5 7.5e-26 -0.54 0.02 0.27 FALSE
106 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 6.218 -5.2 1.9e-07 0.62 0.32 0.05 FALSE