[Hub]/) : Traits : Basal metabolic rate :

chr5:175,662,866-177,260,129

Best TWAS P=3.3e-12 · Best GWAS P=5.43e-13 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RAB24 0.14 0.06 enet 14 0.09 4.2e-11 4.6 5.5 3.4e-08 0.18 1.00 0.00 TRUE
2 GTEx Adipose Subcutaneous RAB24 0.17 0.08 enet 26 0.14 1.7e-11 4.5 5.7 1.4e-08 0.44 0.98 0.01 FALSE
3 GTEx Adipose Subcutaneous MXD3 0.16 0.05 enet 13 0.06 1.7e-05 6.1 6.1 8.7e-10 0.77 0.02 0.98 FALSE
4 GTEx Adipose Visceral Omentum MXD3 0.33 0.06 lasso 6 0.05 9.1e-04 6.1 5.4 6.5e-08 0.84 0.04 0.88 FALSE
5 GTEx Artery Tibial RAB24 0.18 0.09 lasso 3 0.07 2.3e-06 4.5 5.8 7.2e-09 0.49 0.98 0.01 TRUE
6 GTEx Artery Tibial MXD3 0.12 0.13 enet 5 0.12 7.0e-10 6.1 6.2 5.2e-10 0.89 0.17 0.83 FALSE
7 GTEx Brain Cerebellum MXD3 0.28 0.31 lasso 2 0.30 1.6e-09 6.1 6.1 1.4e-09 0.87 0.09 0.90 FALSE
8 GTEx Brain Cortex MXD3 0.47 0.20 lasso 10 0.22 7.7e-07 6.1 5.2 1.5e-07 0.78 0.06 0.60 FALSE
9 GTEx Brain Nucleus accumbens basal ganglia MXD3 0.24 0.14 enet 10 0.25 2.9e-07 6.1 5.9 3.5e-09 0.83 0.05 0.82 FALSE
10 GTEx Breast Mammary Tissue MXD3 0.26 0.08 lasso 5 0.10 1.3e-05 6.1 6.3 3.6e-10 0.86 0.00 1.00 FALSE
11 GTEx Breast Mammary Tissue (Female) MXD3 0.23 0.08 lasso 3 0.09 1.1e-03 7.2 6.0 2.1e-09 0.82 0.01 0.92 FALSE
12 GTEx Colon Sigmoid MXD3 0.35 0.27 lasso 9 0.29 6.3e-11 6.1 6.0 2.3e-09 0.90 0.04 0.96 TRUE
13 GTEx Colon Transverse PRELID1 0.31 0.28 lasso 4 0.26 1.1e-12 6.1 -6.2 5.5e-10 -0.90 0.03 0.97 FALSE
14 GTEx Esophagus Gastroesophageal Junction MXD3 0.17 0.12 lasso 3 0.08 9.5e-04 6.1 5.2 2.5e-07 0.78 0.03 0.62 FALSE
15 GTEx Esophagus Mucosa UIMC1 0.08 0.00 lasso 5 0.00 3.5e-01 -6.0 -6.1 1.3e-09 -0.19 0.13 0.05 TRUE
16 GTEx Esophagus Mucosa FGFR4 0.18 0.16 enet 8 0.16 9.2e-11 -6.0 -5.8 8.0e-09 -0.21 0.79 0.21 FALSE
17 GTEx Esophagus Mucosa MXD3 0.16 0.14 lasso 8 0.15 1.7e-10 6.1 5.9 3.9e-09 0.85 0.23 0.76 FALSE
18 GTEx Esophagus Muscularis MXD3 0.27 0.20 enet 10 0.24 1.6e-14 6.1 6.2 5.3e-10 0.91 0.08 0.92 FALSE
19 GTEx Heart Atrial Appendage MXD3 0.33 0.15 enet 24 0.16 1.5e-07 6.1 5.9 4.0e-09 0.76 0.00 1.00 FALSE
20 GTEx Heart Left Ventricle MXD3 0.17 0.03 lasso 3 0.03 1.5e-02 6.1 6.0 1.6e-09 0.86 0.10 0.36 FALSE
21 GTEx Liver PRELID1 0.22 0.25 lasso 3 0.24 2.4e-07 7.2 -7.0 3.3e-12 -0.98 0.00 1.00 TRUE
22 GTEx Lung MXD3 0.20 0.12 lasso 10 0.12 1.8e-09 6.1 6.3 3.6e-10 0.85 0.12 0.88 FALSE
23 GTEx Nerve Tibial FGFR4 0.44 0.48 lasso 7 0.47 2.1e-37 -6.0 -5.9 4.4e-09 -0.19 0.79 0.21 FALSE
24 GTEx Nerve Tibial RAB24 0.27 0.08 enet 32 0.17 6.3e-12 1.8 6.4 2.1e-10 0.52 0.77 0.12 FALSE
25 GTEx Nerve Tibial MXD3 0.26 0.17 lasso 7 0.28 6.9e-20 6.1 6.4 1.6e-10 0.87 0.04 0.96 FALSE
26 GTEx Pituitary MXD3 0.25 0.20 lasso 6 0.16 7.5e-05 5.4 6.0 2.6e-09 0.74 0.03 0.91 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic MXD3 0.22 0.18 lasso 3 0.17 1.8e-09 6.1 6.6 4.3e-11 0.94 0.01 0.99 FALSE
28 GTEx Skin Sun Exposed Lower leg PRELID1 0.06 0.02 enet 5 0.03 3.4e-03 6.1 -6.1 1.3e-09 -0.92 0.01 0.99 FALSE
29 GTEx Skin Sun Exposed Lower leg MXD3 0.19 0.14 lasso 6 0.12 4.2e-10 7.2 6.5 8.0e-11 0.91 0.00 1.00 FALSE
30 GTEx Small Intestine Terminal Ileum PRELID1 0.47 0.16 enet 10 0.13 7.6e-04 7.2 -6.7 2.0e-11 -0.94 0.00 0.97 FALSE
31 GTEx Thyroid MXD3 0.31 0.17 lasso 8 0.24 1.1e-18 6.1 6.6 3.6e-11 0.91 0.00 1.00 FALSE
32 METSIM Adipose MXD3 0.18 0.18 lasso 3 0.21 1.3e-30 6.1 6.1 8.7e-10 0.86 0.58 0.42 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma RAB24 0.08 0.04 enet 7 0.06 3.4e-04 -2.6 5.6 2.4e-08 0.57 0.04 0.10 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FGFR4 0.08 0.06 blup 46 0.07 2.5e-08 3.0 -5.6 2.6e-08 -0.39 0.19 0.80 FALSE
35 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma LMAN2 0.04 0.00 blup 46 0.00 1.6e-01 7.2 -5.3 1.1e-07 -0.77 0.00 0.91 TRUE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PRELID1 0.24 0.11 lasso 5 0.10 1.2e-11 6.4 -6.3 2.7e-10 -0.88 0.20 0.80 TRUE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PRELID1 0.33 0.08 enet 4 0.08 2.7e-05 6.1 -6.2 4.5e-10 -0.90 0.13 0.75 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma FGFR4 0.06 0.02 enet 7 0.05 1.2e-06 -2.2 -5.2 1.6e-07 -0.27 0.04 0.90 FALSE
39 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PRELID1 0.08 0.10 lasso 4 0.07 2.9e-04 5.5 -5.7 1.1e-08 -0.83 0.02 0.92 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma MXD3 0.04 0.02 blup 40 0.03 2.8e-04 6.1 5.6 1.9e-08 0.84 0.10 0.77 TRUE