Hub : Genes

UIMC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1470 0.0300 2.8e-16 0.194 0.143 0.181 0.173 0.191 4.8e-23 4.3e-17 1.7e-21 1.7e-20 9.3e-23
2 GTEx Adipose Subcutaneous 0.1210 0.0460 3.8e-04 0.029 NA 0.010 NA 0.023 1.9e-03 NA 5.1e-02 NA 5.0e-03
3 GTEx Brain Cortex 0.2900 0.1410 6.1e-03 0.002 NA 0.012 NA -0.010 2.8e-01 NA 1.4e-01 NA 8.0e-01
4 GTEx Esophagus Mucosa 0.0770 0.0330 4.0e-03 0.001 NA -0.001 NA -0.001 2.9e-01 NA 3.6e-01 NA 3.5e-01
5 GTEx Esophagus Muscularis 0.0930 0.0330 6.9e-04 0.055 NA 0.038 NA 0.026 2.8e-04 NA 2.3e-03 NA 9.7e-03
6 GTEx Skin Not Sun Exposed Suprapubic 0.1460 0.0600 5.0e-03 -0.003 NA 0.000 NA -0.005 5.1e-01 NA 3.1e-01 NA 8.0e-01
7 GTEx Skin Sun Exposed Lower leg 0.1590 0.0430 1.5e-07 0.076 NA 0.139 NA 0.122 6.8e-07 NA 1.5e-11 NA 2.7e-10
8 GTEx Testis 0.1260 0.0410 2.9e-04 0.179 NA 0.157 NA 0.063 2.2e-08 NA 1.9e-07 NA 8.9e-04
9 GTEx Thyroid 0.1010 0.0330 6.5e-05 0.101 NA 0.087 NA 0.098 4.1e-08 NA 3.3e-07 NA 6.0e-08
10 METSIM Adipose 0.0681 0.0205 1.3e-06 0.058 0.029 0.044 0.021 0.015 4.6e-09 3.3e-05 3.6e-07 2.9e-04 1.8e-03
11 YFS Blood 0.0334 0.0116 2.5e-06 0.008 0.011 0.011 0.009 0.004 6.4e-04 1.2e-04 1.1e-04 4.1e-04 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.2 0.4 2.9 0.0 -0.3 0.3 0.5 -0.8 0.0 1.7 0.2 0.0 0.3 0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 1.9 1.0 -1.1 1.4 0.8 -0.6 0.0 0.7 -0.8 -1.1 -0.6 0.0
Depressed Affect (Nagel 2018) 0.4 0.8 2.0 -1.0 1.1 1.0 -0.2 1.4 0.0 0.6 0.8 1.1 -1.1 -0.3
Depression (Nagel 2018) 1.5 2.3 4.0 -1.9 2.0 1.7 -0.0 1.9 0.0 1.5 1.6 2.0 0.9 1.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 5.8 0.2 -0.2 -0.3 -2.4 -0.2 0.0 -0.0 -0.2 0.1 -0.2 1.3
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -0.8 0.9 -0.3 -0.9 1.0 0.0 0.1 0.6 0.9 -1.0 -0.1
Schizophrenia (2018) 0.5 1.0 2.1 1.3 -1.1 1.4 0.6 -0.2 0.0 -0.5 -1.2 -1.4 -1.2 -0.4
Schizophrenia vs Biploar Disorder 0.1 0.2 0.9 -0.4 0.4 -0.0 -0.4 1.0 0.0 -0.5 0.2 0.4 0.1 0.4
Worry (Nagel 2018) 0.1 0.1 0.3 -0.4 0.4 -0.3 0.0 -0.3 0.0 0.1 0.5 0.5 -0.3 0.6
Alzheimer’s Disease (in mother) 0.3 0.3 2.3 -0.1 -0.1 -0.8 1.5 0.5 0.0 0.1 -0.1 0.0 0.4 -0.6
Alzheimer’s Disease (in father) 0.9 0.9 2.2 -1.2 1.2 -0.3 -0.3 1.5 0.0 -0.2 0.8 1.2 0.9 1.4
Alzheimer’s Disease (including proxy) 0.2 0.3 1.3 -0.0 -0.1 -1.1 1.1 0.6 0.0 -0.8 -0.5 -0.0 0.2 -0.0
Crohns Disease (2017) 0.2 0.4 2.3 0.2 -0.4 -0.4 0.4 -1.1 0.0 0.1 0.2 -0.2 0.3 -1.5
Irritable Bowel Disease (IBD) 0.6 1.3 7.3 0.9 -1.1 -0.9 -0.7 -2.7 0.0 -0.7 -0.6 -0.9 -0.8 -1.4
Ulcerative Colitis (UC) 0.7 1.4 7.6 0.9 -0.9 -0.5 -1.6 -2.8 0.0 -1.1 -0.7 -0.8 -0.9 -0.1
Major Depression (MDD) 0.4 0.5 1.3 -0.8 0.9 0.0 0.5 0.8 0.0 1.2 0.7 0.8 0.6 0.5
Reaction Time 4.0 7.6 12.1 3.2 -2.9 -3.5 -1.6 -3.2 0.0 -3.3 -3.3 -3.1 -2.3 -1.7
Verbal and Numeric Reasoning (VNR) 0.3 0.8 6.9 0.2 0.0 -0.7 -2.6 -0.6 0.0 0.0 -0.0 0.0 -0.6 0.3
Breast Cancer 0.1 0.2 2.3 0.2 -0.1 0.0 -0.0 0.0 0.0 -1.5 -0.4 -0.2 -0.3 -0.1
Ovarian Cancer 0.2 0.3 0.7 -0.7 0.6 -0.4 -0.7 0.7 0.0 0.4 0.5 0.8 0.6 0.4
Prostate Cancer 0.3 0.4 2.0 0.2 -0.1 -1.4 -0.8 -1.1 0.0 -0.3 -0.2 -0.1 -0.6 0.5
Age at First Birth 2.3 3.3 5.2 2.3 -2.1 -1.0 -2.1 -2.1 0.0 -1.4 -2.2 -2.2 -1.7 -1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.2
Body Mass Index (BMI) (2010) 1.0 1.3 9.2 -0.5 0.2 -0.1 3.0 0.9 0.0 1.3 0.6 0.3 -0.4 -1.4
Coronary Artery Disease (CAD) 0.7 0.8 2.2 0.6 -0.5 -1.4 -0.8 -1.5 0.0 -1.1 -0.7 -0.5 -1.1 -0.8
Crohns Disease (2012) 1.1 1.8 3.7 1.6 -1.6 -1.9 -0.1 -1.6 0.0 -1.0 -1.1 -1.5 -0.8 -1.7
Mean Putamen Volume 0.3 0.3 1.1 -0.0 0.4 -1.0 -1.1 0.1 0.0 0.1 0.1 0.1 0.5 1.1
Fasting Glucose 2.2 2.7 8.2 -2.1 2.0 0.3 0.8 2.9 0.0 1.0 1.8 2.1 1.8 0.4
HbA1C 0.3 0.3 1.1 0.4 -0.4 0.8 -0.5 -0.5 0.0 -0.7 -0.3 -0.4 -1.1 -0.1
HDL Cholesterol 1.5 2.5 4.0 2.0 -1.9 -1.6 -0.9 -1.9 0.0 -1.2 -1.8 -1.9 -2.0 -0.4
LDL Cholesterol 0.5 0.8 1.7 -0.9 1.0 1.3 -0.5 0.9 0.0 0.6 1.0 1.0 1.3 -0.2
Lupus 0.7 1.1 2.2 -1.2 1.5 0.1 -0.1 1.3 0.0 1.3 1.2 1.1 0.8 1.1
Neuroticism (2016) 2.5 3.6 7.2 -2.4 2.2 0.8 2.1 2.7 0.0 1.6 2.5 2.3 0.6 -1.2
Primary Biliary Cirrhosis 1.1 1.6 6.2 -1.4 1.3 0.7 -0.1 0.0 0.0 2.5 1.6 1.5 0.9 1.3
Rheumatoid Arthritis 0.3 0.4 1.3 -0.3 0.4 1.2 -0.8 -0.9 0.0 0.1 0.4 0.4 0.0 0.7
Schizophrenia (2014) 0.4 0.9 2.3 1.4 -1.3 0.8 0.6 -0.3 0.0 -0.5 -1.2 -1.5 -1.0 -0.5
Triglycerides 0.1 0.2 0.6 0.4 -0.3 -0.6 0.2 -0.8 0.0 0.1 -0.2 -0.4 -0.2 -0.6
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.9 -0.1 0.1 0.1 0.3 -1.0 0.0 0.4 0.2 0.2 0.5 0.4
Ulcerative Colitis 1.6 2.3 8.1 1.8 -1.6 -0.4 -1.4 -2.8 0.0 -1.1 -1.5 -1.6 -1.6 -0.7
Blood Eosinophil Count 0.7 5.8 19.8 2.8 -2.7 -1.3 -1.2 -4.5 0.0 -1.6 -2.6 -2.7 -2.4 -1.6
Blood Platelet Count 0.1 1.4 6.9 -0.0 -0.1 1.0 2.6 0.4 0.0 1.0 0.0 -0.2 1.4 2.1
Blood Red Count 0.7 6.7 36.8 2.2 -2.1 -1.5 -1.0 -6.1 0.0 -1.5 -2.1 -2.1 -3.0 -2.1
Blood White Count 0.1 0.8 1.9 -1.1 0.8 0.6 -0.4 -1.4 0.0 1.0 1.4 1.1 0.7 0.4
Heel T-Score 0.7 5.2 9.2 -3.0 2.7 -1.0 3.0 0.6 0.0 2.3 2.8 2.9 2.7 1.4
BMI 0.4 2.2 14.8 0.1 -0.2 -1.3 3.9 0.1 0.0 0.5 0.1 -0.3 -1.8 -2.2
Height 5.6 107.3 585.1 8.7 -7.0 -6.5 -24.2 -9.7 0.0 -12.5 -8.5 -7.2 -5.9 -4.2
Waist Hip Ratio (WHR) 2.1 9.4 82.6 1.7 -1.0 1.0 -9.1 -1.8 0.0 -3.0 -1.4 -1.1 -0.3 -0.2
Systolic Blood Pressure 0.1 0.5 1.1 -0.7 0.5 -0.8 0.9 0.2 0.0 1.0 1.0 0.7 0.6 0.1
Smoking Status 1.5 3.6 7.4 -2.6 2.3 0.2 1.2 2.7 0.0 1.6 2.3 2.5 2.0 0.0
Allergy or Eczema 0.8 2.2 8.3 1.3 -1.1 -2.0 -2.0 -2.9 0.0 0.7 -1.0 -1.1 -1.6 -0.2
Cardiovascular Disease 0.1 0.5 3.4 0.3 -0.3 -0.2 0.8 0.3 0.0 -0.5 -0.3 -0.3 -0.6 -1.8
Hypothyroidism (self reported) 0.8 1.8 3.9 1.2 -0.9 -2.0 -1.8 -1.6 0.0 -1.9 -1.3 -1.2 -1.0 -0.4
Respiratory disease 0.2 0.4 1.6 0.4 -0.0 -1.3 0.1 -1.0 0.0 0.5 -0.1 -0.4 -0.3 -0.8
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.5 0.1 -0.3 -1.2 0.1 -0.7 0.0 -0.2 -0.2 -0.1 -1.1 -0.3
Lung FEV1/FVC ratio 0.6 3.2 15.9 -1.1 0.8 -1.1 2.5 4.0 0.0 1.2 0.9 0.9 1.8 1.9
Lung FVC 0.1 0.3 0.9 -0.5 0.3 -0.9 0.4 1.0 0.0 0.8 0.5 0.5 -0.4 -0.5
Neuroticism 0.6 1.5 4.1 -1.6 1.6 -0.8 -0.3 2.0 0.0 0.6 1.5 1.7 -0.6 -0.7
Chronotype (morning person) 0.1 0.2 0.7 -0.3 0.5 0.9 0.1 0.5 0.0 -0.6 0.1 0.3 0.7 0.2
Hair Pigment 0.1 2.4 8.6 -1.4 1.4 2.9 -1.8 -0.7 0.0 1.4 1.4 1.5 0.7 1.8
Tanning 0.2 2.0 3.7 1.4 -1.8 -1.9 1.1 -0.6 0.0 -1.6 -1.5 -1.6 -1.3 -1.8
Hand grip strength (left) 0.5 1.4 4.7 1.0 -1.1 -1.4 -2.2 -1.5 0.0 -0.5 -1.0 -0.9 -0.9 -0.9
Number of treatments/medications taken 0.5 0.9 2.3 -1.3 1.5 -0.1 -0.8 0.8 0.0 0.5 1.3 1.5 0.6 0.5
Average weekly spirits intake 0.5 0.6 2.0 -0.8 1.1 -0.7 -1.4 0.9 0.0 0.2 0.9 0.9 0.3 0.0
Sensitivity / hurt feelings 0.4 0.6 2.3 0.7 -0.7 -0.5 -1.5 -0.5 0.0 -0.6 -0.7 -0.5 -1.1 -0.8
Frequency of depressed mood in last 2 weeks 0.7 0.9 5.3 -0.8 0.6 2.3 0.4 0.9 0.0 1.1 0.7 0.8 0.3 0.6
Hearing difficulty/problems: Yes 1.7 2.6 7.1 -1.7 1.9 0.2 1.0 1.5 0.0 2.7 1.6 1.7 1.3 2.2
Relative age of first facial hair 0.0 0.1 0.6 -0.0 0.2 0.7 -0.4 0.4 0.0 0.1 0.2 0.1 0.3 0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 6.2 0.3 -0.1 0.8 -2.5 -1.2 0.0 0.1 -0.2 -0.1 -0.4 -0.5
Ever used hormone-replacement therapy (HRT) 7.8 9.9 15.5 3.9 -3.7 -3.2 -1.0 -3.9 0.0 -2.7 -3.6 -3.9 -3.5 -2.5
Ever had hysterectomy (womb removed) 3.9 4.4 6.7 -2.3 2.3 2.4 2.1 2.3 0.0 2.6 2.5 2.2 2.0 1.1
Systolic blood pressure, automated reading 0.4 1.0 3.6 -0.7 0.7 -0.9 1.9 0.9 0.0 1.5 1.1 0.7 0.2 -1.1
Eye problems/disorders: Diabetes related eye disease 1.7 1.8 3.6 1.4 -1.6 -1.9 -1.1 -1.1 0.0 -1.7 -1.4 -1.3 -1.5 -1.0
Angina 1.2 1.6 3.0 -1.5 1.7 1.3 -0.0 1.1 0.0 0.6 1.4 1.5 1.3 1.7
Medication for hormone replacement therapy 0.1 0.1 1.0 -0.0 -0.0 -1.0 0.4 0.1 0.0 -0.4 0.0 0.0 -0.0 0.4
Vitamin and mineral supplements 2.4 3.3 6.4 1.8 -1.9 -2.4 -1.8 -1.5 0.0 -2.5 -2.0 -1.7 -2.1 -0.1
Supplements: Zinc 0.3 0.3 0.9 -0.2 0.2 -0.4 0.9 0.4 0.0 0.8 0.4 0.3 0.6 -0.8
Medication: Co-codamol 2.3 2.6 4.1 -2.0 2.0 0.9 1.5 1.2 0.0 1.7 1.9 2.0 1.6 2.0
Medication: Metformin 1.7 2.4 5.8 1.5 -1.4 -2.4 -1.6 -1.7 0.0 -1.6 -1.3 -1.4 -1.4 -1.6
Diabetes (father) 0.3 0.3 2.3 0.3 -0.4 0.6 -0.2 -1.5 0.0 0.0 -0.2 -0.3 0.0 -0.6
Diabetes (mother) 0.4 0.5 2.9 -0.7 0.5 -0.1 1.7 0.5 0.0 0.1 0.7 0.6 0.8 0.5
Severe depression (siblings) 1.7 1.9 3.9 -1.8 1.6 -0.1 1.3 1.8 0.0 1.5 2.0 1.7 1.0 0.2
Pack years adult smoking proportion 0.4 0.6 3.5 -0.2 0.3 -1.3 -1.9 -0.2 0.0 -0.8 0.2 0.3 0.3 -0.3
Impedance of leg (right) 1.0 4.9 11.6 -1.4 1.5 3.4 -3.4 1.3 0.0 -1.0 0.8 1.6 3.0 3.3
Leg fat-free mass (left) 2.0 10.7 19.4 3.1 -2.6 -4.0 -4.4 -3.2 0.0 -3.0 -2.7 -2.8 -4.0 -3.9
Trunk fat percentage 0.6 2.4 4.3 1.8 -1.6 -2.1 0.1 -1.2 0.0 -1.7 -1.9 -1.8 -1.7 -1.4
Hand grip strength (right) 0.6 1.6 6.5 1.1 -1.2 -1.0 -2.5 -1.6 0.0 -0.6 -0.9 -0.9 -0.7 -1.4
Townsend deprivation index at recruitment 0.7 1.0 3.7 -0.8 0.9 1.9 1.1 1.0 0.0 1.0 1.1 0.7 1.2 -0.2
Current tobacco smoking 3.8 6.3 13.1 -3.2 3.2 1.0 0.9 3.6 0.0 2.6 3.1 3.2 2.3 1.3
Average weekly fortified wine intake 1.2 1.4 4.9 -1.3 1.3 0.6 -0.2 2.2 0.0 0.4 1.1 1.3 1.4 1.1
Maternal smoking around birth 0.5 0.7 1.6 -1.1 1.1 0.3 0.1 0.8 0.0 1.0 1.1 1.1 1.3 -0.2
Fed-up feelings 1.8 3.2 6.1 -2.4 2.5 1.5 1.1 2.1 0.0 1.7 2.4 2.4 0.5 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 4.8 -2.1 2.1 1.8 -0.3 1.8 0.0 1.2 2.0 2.2 1.2 2.0
Relative age voice broke 0.4 0.6 1.3 -0.6 0.9 0.8 -1.0 0.8 0.0 0.1 0.7 0.7 1.0 1.1
Taking other prescription medications 0.6 0.9 2.2 -1.2 1.5 -0.5 -1.3 0.1 0.0 0.3 1.3 1.3 0.7 0.2
Age when periods started (menarche) 2.7 6.5 10.6 2.8 -2.7 -2.1 -1.4 -2.4 0.0 -3.3 -3.2 -2.8 -3.2 -2.1
Bilateral oophorectomy (both ovaries removed) 5.0 5.8 10.5 -2.8 2.8 2.1 1.4 3.2 0.0 2.6 3.0 2.7 2.6 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.6 -0.3 0.3 -1.2 0.7 -0.4 0.0 0.4 0.1 0.3 0.3 0.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.5 -0.7 0.7 1.2 -0.3 0.2 0.0 -0.6 0.4 0.7 0.7 0.8
Qualifications: CSEs or equivalent 0.7 0.9 4.3 -0.9 0.8 1.0 2.1 0.7 0.0 0.4 1.0 0.8 0.6 -0.7
Serious illness, injury or assault to yourself 0.3 0.4 1.0 -0.6 0.6 0.6 -1.0 -0.5 0.0 0.5 0.7 0.7 0.6 0.6
High blood pressure 0.6 1.7 7.2 1.1 -1.2 -1.9 -0.0 -0.7 0.0 -0.8 -1.1 -1.1 -1.2 -2.7
Hayfever, allergic rhinitis or eczema 0.5 1.1 4.1 0.7 -0.5 -1.1 -2.0 -2.0 0.0 0.5 -0.5 -0.5 -1.1 0.0
Multivitamins +/- minerals 1.4 1.8 3.4 -1.5 1.5 1.5 1.8 1.0 0.0 1.3 1.6 1.4 1.3 0.3
Stomach or abdominal pain in last month 0.2 0.3 2.3 -0.0 -0.0 -0.1 -0.4 -0.2 0.0 -0.2 0.1 0.1 -0.9 1.5
Supplements: Glucosamine 0.3 0.4 1.7 0.7 -0.7 -0.3 -0.1 0.1 0.0 0.5 -0.7 -0.6 -1.3 -0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.4 1.3 -1.2 -0.8 -0.8 -1.3 0.0 -1.0 -1.4 -1.3 -1.2 -1.5
Medication: Atenolol 0.1 0.1 0.6 -0.2 0.2 -0.2 0.5 0.4 0.0 0.0 0.0 0.2 0.5 0.8
Medication: Levothyroxine sodium 0.4 0.6 3.9 0.6 -0.6 -2.0 -0.4 -0.5 0.0 -0.9 -0.6 -0.6 -0.4 -0.5
Sitting height 0.4 2.9 7.6 1.7 -1.6 -2.8 -2.1 -1.0 0.0 -1.4 -1.5 -1.6 -1.1 -2.4
Chronic bronchitis/emphysema (father) 1.4 1.7 5.6 1.2 -1.3 -1.5 -0.4 -1.4 0.0 -1.3 -0.8 -1.3 -1.2 -2.4
High blood pressure (mother) 0.5 0.8 3.3 -0.5 0.4 -1.8 1.8 0.8 0.0 0.5 0.4 0.4 0.2 -0.4
Body mass index (BMI) 0.5 2.1 8.6 0.5 -0.5 -1.8 2.9 -0.3 0.0 -0.0 -0.3 -0.8 -1.8 -2.6
Impedance of leg (left) 1.0 4.7 14.7 -1.4 1.4 2.9 -3.0 1.4 0.0 -0.8 0.8 1.6 3.2 3.8
Leg predicted mass (left) 2.1 11.3 19.8 3.2 -2.7 -4.2 -4.5 -3.3 0.0 -3.1 -2.8 -2.9 -4.1 -4.0
Trunk fat mass 1.0 4.2 7.2 2.1 -1.7 -2.7 -1.9 -1.8 0.0 -2.3 -2.2 -2.0 -2.3 -2.2
Waist circumference 1.0 3.8 9.0 1.8 -1.3 -1.8 -3.0 -1.7 0.0 -1.9 -1.5 -1.6 -2.1 -2.9
Number of incorrect matches in round 5.2 8.7 14.0 3.6 -3.4 0.4 -1.9 -3.7 0.0 -2.9 -3.4 -3.5 -3.3 -3.0
Past tobacco smoking 0.4 0.7 2.3 0.8 -0.7 -0.1 -1.4 -1.5 0.0 -0.5 -0.8 -0.7 -0.6 0.6
Alcohol usually taken with meals 1.6 2.6 6.4 2.2 -2.2 -0.7 -0.8 -2.1 0.0 -0.8 -2.5 -2.1 -1.4 -0.7
Nervous feelings 0.1 0.2 1.1 -0.2 0.1 0.8 0.1 -0.2 0.0 -0.0 0.1 0.2 0.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 3.4 -1.8 1.8 1.9 -0.7 1.4 0.0 0.7 1.7 1.8 1.0 1.3
Hearing difficulty/problems with background noise 0.1 0.2 1.3 -0.2 0.5 -0.6 -1.2 -0.1 0.0 0.0 0.1 0.3 -0.2 0.4
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 0.6 -0.6 0.6 -0.1 -0.8 0.0 0.4 -0.6 -0.6 -0.3 -0.8
Had menopause 33.6 42.0 70.1 8.3 -7.9 -4.5 -3.1 -5.9 0.0 -6.7 -8.4 -8.2 -6.7 -6.3
Had other major operations 1.9 2.4 6.2 -1.6 1.5 -0.6 2.5 2.3 0.0 1.6 1.8 1.4 1.3 0.0
Forced vital capacity (FVC) 1.2 4.6 31.3 1.2 -1.0 -1.9 -5.6 -1.8 0.0 -2.1 -1.2 -0.9 -1.6 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.6 3.2 0.3 -0.2 -1.8 0.3 -1.5 0.0 -0.2 -0.4 -0.3 0.0 0.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.3 -0.7 0.6 -0.7 -0.4 -0.2 0.0 0.6 0.5 0.7 0.1 1.1
Qualifications: None of the above 0.5 1.0 2.6 -1.5 1.5 -0.7 -0.2 0.7 0.0 0.0 1.6 1.5 1.0 0.5
Financial difficulties in last 2 years 5.7 7.6 12.4 -2.9 3.0 1.7 3.4 3.5 0.0 3.4 2.8 2.7 2.5 2.6
Mouth/teeth dental problems 0.2 0.3 0.9 0.4 -0.4 1.0 -0.2 -0.8 0.0 -0.8 -0.5 -0.4 -0.0 0.4
Heart attack 2.0 2.6 5.6 -1.8 2.0 2.1 0.8 2.4 0.0 1.2 1.8 1.8 1.1 1.4
Allergy 0.3 0.7 3.0 -0.5 0.2 0.8 1.5 1.7 0.0 -1.1 0.3 0.3 0.6 0.1
Pain all over the body in last month 0.5 0.5 3.2 0.3 -0.3 0.2 -0.5 0.2 0.0 -1.0 -0.1 -0.3 -0.8 -1.8
Diabetes (self-reported) 0.6 0.9 3.7 0.7 -0.9 -1.9 0.1 -1.0 0.0 -0.7 -0.7 -0.7 -1.3 -0.8
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 7.8 -1.8 2.0 1.2 -0.4 0.5 0.0 1.2 1.7 1.9 1.9 2.8
Medication: Ramipril 0.3 0.4 1.1 0.6 -0.7 -0.0 0.1 -0.7 0.0 -1.0 -0.8 -0.6 -0.8 -0.2
Medication: Simvastatin 0.1 0.2 0.5 -0.4 0.4 -0.6 0.2 -0.2 0.0 0.2 0.5 0.4 0.1 0.7
Fluid intelligence score 0.3 0.6 5.0 0.4 -0.4 0.2 -2.2 -1.0 0.0 0.1 -0.1 -0.2 -0.1 0.3
Illnesses of siblings 0.4 0.6 1.4 0.9 -0.7 0.6 -0.4 -1.2 0.0 -0.6 -0.7 -1.0 -0.7 0.6
Neuroticism score 0.6 1.2 2.7 -1.6 1.5 0.5 0.3 1.3 0.0 1.0 1.5 1.6 0.0 0.1
Weight 1.6 8.0 17.1 2.6 -2.1 -3.4 -4.1 -2.6 0.0 -3.1 -2.4 -2.4 -3.1 -3.3
Impedance of arm (right) 0.3 1.3 5.6 0.5 -0.5 1.8 -1.1 -0.1 0.0 -1.2 -0.9 -0.4 1.1 2.4
Arm fat percentage (right) 0.4 1.4 7.1 0.8 -0.7 -1.0 2.7 -0.7 0.0 -0.4 -0.8 -0.9 -1.5 -1.6
Trunk fat-free mass 2.2 12.5 61.1 2.6 -2.0 -3.1 -7.8 -3.4 0.0 -3.6 -2.3 -2.2 -3.1 -3.4
Hip circumference 0.9 3.8 8.4 1.8 -1.7 -2.9 -0.2 -2.2 0.0 -1.8 -1.6 -1.8 -2.5 -2.7
Time employed in main current job 0.7 0.8 2.0 0.6 -0.8 -0.8 -1.4 -1.2 0.0 -1.4 -0.6 -0.5 -0.3 -0.8
Alcohol intake versus 10 years previously 1.3 2.0 4.5 -1.7 1.6 -0.1 0.8 0.7 0.0 1.2 1.7 1.7 2.1 1.9
Father’s age at death 0.7 0.9 2.5 1.2 -1.2 -0.3 -0.0 -1.6 0.0 -0.5 -1.3 -1.3 -0.6 -0.6
Worrier / anxious feelings 0.4 0.8 2.5 0.9 -0.8 0.4 -1.6 -0.8 0.0 -1.2 -1.0 -0.8 -1.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.7 -1.2 1.0 1.3 1.6 1.5 0.0 0.4 1.2 1.1 0.2 0.3
Falls in the last year 0.3 0.4 0.9 0.7 -0.4 -0.9 -0.5 -0.9 0.0 -0.3 -0.8 -0.7 -0.6 0.1
Hair/balding pattern: Pattern 3 0.8 1.2 2.6 -1.2 1.2 0.9 1.6 1.3 0.0 0.9 1.2 1.1 1.1 1.0
Number of live births 0.3 0.5 0.9 -0.6 0.9 0.9 -0.8 0.6 0.0 0.4 1.0 0.6 0.7 -0.5
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 14.9 0.5 -0.6 -1.4 -3.9 -0.6 0.0 -1.4 -0.6 -0.3 -0.5 0.7
Pulse rate 0.1 0.2 0.7 -0.4 0.5 0.1 -0.9 0.3 0.0 -0.5 0.3 0.5 -0.0 0.7
Happiness 0.3 0.4 2.7 0.6 -0.4 0.5 -0.2 0.1 0.0 -0.4 -0.4 -0.5 -0.4 -1.6
Noisy workplace 0.8 1.0 3.4 -1.2 1.2 0.0 1.5 1.8 0.0 0.3 1.1 1.1 0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.1 0.5 -0.9 0.2 0.4 -1.5 0.0 0.2 -0.7 -0.6 0.5 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.7 0.6 -0.6 -1.0 1.9 -0.2 0.0 -0.0 -0.9 -0.7 -0.0 -1.3
Mouth/teeth dental problems: Dentures 0.5 0.9 2.5 -1.1 1.1 -0.1 0.9 0.8 0.0 1.6 1.2 1.1 0.7 0.3
Asthma 0.4 0.8 3.0 1.0 -0.6 -1.4 -0.3 -1.7 0.0 0.0 -0.7 -0.9 -0.7 -0.8
Medication: Ibuprofen (e.g. Nurofen) 4.0 5.1 10.6 -2.6 2.6 1.7 0.3 3.3 0.0 1.7 2.6 2.6 3.0 1.6
Medication: Cholesterol lowering 0.0 0.1 0.3 0.1 -0.2 -0.2 0.4 -0.2 0.0 -0.3 -0.2 -0.1 -0.5 0.3
Depression (self-reported) 0.7 0.8 5.5 -0.5 0.5 1.2 2.4 0.5 0.0 0.9 0.4 0.3 0.1 -0.0
Medication: Lansoprazole 0.3 0.4 0.8 -0.7 0.7 -0.5 -0.1 0.5 0.0 -0.3 0.6 0.7 0.9 0.8
Prospective memory result 0.3 0.4 1.0 -0.7 0.7 -0.2 0.5 1.0 0.0 0.5 0.5 0.6 0.7 0.9
Lung cancer (father) 1.2 1.4 2.1 -1.4 1.2 1.1 0.9 1.2 0.0 1.4 1.3 1.3 0.7 1.4
Illnesses of mother 0.9 1.2 5.9 -0.4 0.2 2.4 0.0 0.1 0.0 1.3 0.4 0.4 0.7 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 7.7 0.3 -0.3 -1.3 -2.8 0.2 0.0 -1.2 -0.4 -0.2 -0.9 0.5
Pulse wave Arterial Stiffness index 1.3 1.5 3.2 -1.5 1.7 0.6 -1.6 0.4 0.0 1.2 1.5 1.8 1.0 0.7
Impedance of arm (left) 0.3 1.2 4.1 0.7 -0.7 1.1 -1.4 -0.3 0.0 -1.5 -1.1 -0.6 0.7 2.0
Arm fat mass (right) 0.6 2.6 6.3 1.5 -1.2 -2.3 -0.0 -1.5 0.0 -1.4 -1.3 -1.5 -2.2 -2.5
Trunk predicted mass 2.1 12.0 60.1 2.5 -1.9 -3.1 -7.8 -3.2 0.0 -3.6 -2.1 -2.1 -3.1 -3.4
Standing height 3.8 37.8 237.5 4.7 -3.6 -3.9 -15.4 -5.3 0.0 -7.0 -4.7 -3.8 -3.2 -2.1
Length of working week for main job 0.2 0.2 0.9 -0.3 0.4 0.7 -0.7 -0.5 0.0 -0.2 0.2 0.3 0.9 0.4
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.2 -0.4 -0.4 -0.5 -0.4 0.0 -0.5 -0.4 -0.2 -0.2 -0.1
Breastfed as a baby 0.2 0.3 1.2 0.7 -0.5 -1.1 -0.2 0.1 0.0 0.2 -0.6 -0.6 0.1 0.7
Tense / ‘highly strung’ 0.2 0.3 1.4 0.4 -0.4 0.1 0.6 -0.7 0.0 -0.2 -0.3 -0.5 -0.9 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.7 -0.7 0.5 0.7 1.6 0.3 0.0 0.6 0.6 0.6 -0.3 -0.5
Hair/balding pattern: Pattern 4 0.4 1.0 2.5 0.9 -1.0 -1.1 -1.4 -0.4 0.0 -1.6 -1.0 -0.9 -0.4 -1.1
Birth weight of first child 1.1 2.0 9.1 1.1 -0.7 -2.1 -3.0 -1.1 0.0 -1.2 -1.1 -0.9 -1.4 0.1
Peak expiratory flow (PEF) 0.4 0.8 5.3 0.5 -0.7 -0.5 -2.3 -1.1 0.0 -0.5 -0.4 -0.4 -0.4 1.0
Pulse wave reflection index 1.0 1.2 2.2 -1.3 1.4 1.1 0.5 0.8 0.0 1.5 1.2 1.4 1.1 0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.3 -0.0 -0.1 -1.0 0.6 0.6 0.0 -0.3 0.1 -0.1 -1.1 -0.2
Loud music exposure frequency 1.4 1.6 3.1 -1.4 1.4 0.1 1.8 1.6 0.0 1.6 1.4 1.3 1.0 0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.6 -1.1 0.9 1.2 0.7 1.6 0.0 1.5 0.9 1.1 1.0 1.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.2 0.3 -0.6 -1.1 0.8 0.1 0.0 0.2 -0.3 -0.4 0.0 -0.9
Blood clot in the leg (DVT) 2.1 2.7 5.2 -2.0 1.9 0.6 -0.9 1.4 0.0 1.4 1.9 2.1 1.8 2.3
Medication: Paracetamol 8.2 13.5 22.6 -4.6 4.8 3.1 0.7 4.4 0.0 2.8 4.7 4.6 4.3 2.5
Headache pain in last month 0.2 0.3 1.0 0.2 -0.3 -0.3 -0.9 -0.2 0.0 -0.6 -0.1 -0.1 -0.6 -1.0
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.6 -0.6 0.7 0.4 -0.5 0.0 0.0 -0.2 0.7 0.5 0.7 0.5
Glaucoma (self-reported) 0.1 0.1 0.6 0.2 -0.0 0.8 0.3 0.1 0.0 0.0 -0.2 -0.3 -0.5 -0.5
Gout (self-reported) 0.3 0.4 0.8 0.8 -0.9 -0.0 -0.1 -0.6 0.0 -0.7 -0.9 -0.7 -0.7 -0.4
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.9 0.9 -0.8 -2.0 -1.4 -1.4 0.0 -1.5 -1.0 -0.9 -0.4 -0.3
Medication: Amlodipine 0.2 0.3 1.1 0.4 -0.5 -1.1 0.0 -0.7 0.0 -1.1 -0.3 -0.3 -0.1 -0.4
Medication: Ventolin 100micrograms inhaler 0.2 0.3 1.0 0.1 0.0 -0.8 0.8 0.1 0.0 -0.3 -0.2 -0.2 -1.0 -0.7
Birth weight 0.7 1.5 7.7 1.1 -1.3 -2.8 -0.5 -0.9 0.0 -1.0 -1.2 -1.1 -0.9 0.6
Chronic bronchitis/emphysema (mother) 0.5 0.6 3.6 -0.1 0.2 -0.0 -1.9 -1.1 0.0 -0.5 0.3 0.3 -0.2 -1.3
High blood pressure (siblings) 1.3 1.9 3.2 -1.7 1.3 -0.2 1.8 1.8 0.0 1.1 1.4 1.6 1.7 1.1
Forced vital capacity (FVC), Best measure 1.0 3.7 21.8 1.3 -1.0 -1.5 -4.7 -1.5 0.0 -2.2 -1.3 -1.0 -2.0 -0.4
Body fat percentage 0.3 1.1 2.2 1.0 -0.8 -1.5 0.7 -0.7 0.0 -1.1 -1.2 -1.1 -1.2 -1.2
Leg fat percentage (right) 0.1 0.3 1.5 0.0 0.2 -0.4 0.7 0.1 0.0 -0.7 -0.1 -0.1 -0.5 -1.2
Arm fat-free mass (right) 2.0 10.0 39.6 2.4 -1.9 -3.8 -6.3 -2.7 0.0 -3.2 -2.2 -2.1 -3.0 -3.4
Exposure to tobacco smoke outside home 0.5 0.7 1.4 -1.2 1.0 -0.2 0.4 1.0 0.0 0.9 1.0 1.1 0.6 0.9
Comparative body size at age 10 3.9 10.8 24.3 -3.7 3.1 2.7 4.9 3.7 0.0 4.4 3.6 3.4 2.1 1.6
Number of full brothers 1.9 2.4 4.0 -1.6 1.5 2.0 1.2 1.8 0.0 1.3 1.6 1.5 1.8 1.9
Worry too long after embarrassment 0.5 0.9 3.5 0.6 -0.4 -1.1 -0.7 0.5 0.0 -0.8 -0.9 -0.5 -1.6 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 5.8 7.5 12.9 -3.1 2.8 3.6 2.5 2.5 0.0 3.0 3.0 3.0 3.2 1.8
Wheeze or whistling in the chest in last year 0.6 1.0 7.7 0.2 0.1 -0.8 -2.8 -1.3 0.0 -0.4 0.1 0.1 -0.5 -0.9
Number of children fathered 0.5 0.6 2.1 0.7 -0.4 -0.5 -0.5 0.0 0.0 -1.2 -0.7 -0.8 -0.7 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.5 0.3 -0.0 0.2 0.3 -0.2 0.0 0.7 -0.3 -0.2 -0.6 0.1
Age at first live birth 0.6 1.1 3.1 1.3 -1.1 -0.5 -1.8 -1.3 0.0 -0.1 -1.4 -1.2 -0.4 0.7
Pulse wave peak to peak time 1.4 1.7 3.7 1.7 -1.9 -0.7 0.6 -0.8 0.0 -1.5 -1.7 -1.9 -1.1 -0.7
Health satisfaction 1.3 1.6 3.7 -1.8 1.9 0.1 -0.2 1.4 0.0 0.3 1.8 1.8 1.5 0.7
Shortness of breath walking on level ground 0.5 0.6 1.6 -0.9 1.0 0.1 0.4 1.3 0.0 0.5 1.1 0.9 0.0 -0.5
Qualifications: College or University degree 0.8 2.5 5.0 2.2 -2.0 -0.9 -1.8 -1.8 0.0 -0.8 -2.2 -2.1 -1.0 -0.4
Eye problems/disorders: None of the above 0.5 0.6 2.5 -0.4 0.3 1.2 1.6 -0.3 0.0 0.6 0.4 0.2 0.7 0.9
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.1 0.8 -0.7 -0.2 -0.7 -1.0 0.0 -0.2 -1.0 -0.7 -0.4 0.2
Emphysema/chronic bronchitis 0.1 0.2 0.8 0.1 0.2 -0.3 -0.2 0.8 0.0 0.4 -0.3 -0.0 0.3 -0.9
Medication for pain relief, constipation, heartburn 3.5 6.0 12.8 2.9 -3.2 -1.4 0.9 -2.4 0.0 -1.1 -3.1 -3.0 -3.6 -2.2
Neck or shoulder pain in last month 1.8 2.6 5.3 -1.8 1.8 1.8 1.0 2.3 0.0 1.4 2.0 1.9 1.4 0.9
Medication: Blood pressure 0.1 0.2 0.7 -0.1 0.1 0.1 0.6 0.5 0.0 0.8 -0.0 0.2 0.3 0.6
Angina (self-reported) 1.1 1.5 2.9 -1.5 1.7 1.2 0.2 1.3 0.0 0.6 1.3 1.5 1.1 1.5
Migraine (self-reported) 0.3 0.3 1.1 -0.7 0.5 -0.3 0.7 0.5 0.0 1.0 0.6 0.7 0.0 0.1
Medication: Ibuprofen 5.1 6.1 9.8 -2.9 2.7 2.3 0.9 3.0 0.0 2.2 2.9 2.9 3.1 2.3
Medication: Allopurinol 0.5 0.7 1.5 1.0 -1.1 0.1 0.4 -0.0 0.0 -1.0 -1.0 -1.0 -1.2 -0.9
Medication: Omeprazole 1.1 1.3 10.9 0.2 0.3 -0.2 -3.3 -1.1 0.0 -1.5 -0.1 -0.1 0.0 -0.2
Medication: Seretide 50 evohaler 0.1 0.1 0.9 0.1 -0.1 -0.9 0.5 -0.3 0.0 -0.4 -0.1 -0.1 -0.1 0.0
Mean time to correctly identify matches 2.4 4.7 10.2 2.4 -2.0 -3.2 -1.9 -2.0 0.0 -2.6 -2.5 -2.3 -1.6 -1.7
Heart disease (mother) 3.0 3.7 5.0 2.2 -2.1 -1.9 -1.6 -2.0 0.0 -2.2 -2.0 -2.2 -1.6 -2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.0 0.8 -0.7 -0.5 0.9 -0.4 0.0 0.1 -0.9 -0.9 -1.0 -0.3
Whole body fat mass 0.7 2.8 5.0 1.6 -1.3 -2.2 -1.3 -1.5 0.0 -1.8 -1.6 -1.5 -2.0 -2.2
Leg fat mass (right) 0.5 1.9 4.5 1.1 -0.7 -2.0 -1.0 -1.1 0.0 -1.6 -1.1 -1.1 -1.9 -2.1
Arm predicted mass (right) 2.1 10.5 39.7 2.6 -2.0 -3.7 -6.3 -2.9 0.0 -3.2 -2.3 -2.2 -3.1 -3.6
Pulse rate, automated reading 0.3 0.9 2.8 -1.1 1.3 -0.8 -1.7 0.5 0.0 0.0 1.3 1.3 -0.4 -0.1
Alcohol intake frequency. 0.2 0.5 1.8 0.4 -0.4 -0.8 -0.5 -1.4 0.0 -0.0 0.1 -0.3 -0.9 -1.1
Comparative height size at age 10 4.0 22.1 108.2 4.6 -3.9 -3.1 -10.4 -4.8 0.0 -4.1 -4.2 -3.9 -3.2 -2.5
Number of full sisters 1.4 1.7 3.9 -1.6 1.5 -0.2 0.9 2.0 0.0 1.5 1.5 1.6 1.5 0.6
Suffer from ‘nerves’ 0.1 0.2 1.3 -0.3 0.2 -1.1 0.4 -0.4 0.0 0.0 0.3 0.2 -0.3 -0.1
Overall health rating 0.5 1.0 2.8 -1.3 1.7 -0.0 -0.9 1.3 0.0 0.1 1.5 1.4 -0.0 0.1
Chest pain or discomfort 0.9 1.3 3.0 -1.4 1.6 1.3 0.7 1.7 0.0 0.5 1.3 1.3 0.7 0.7
Had major operations 1.0 1.2 2.4 -1.4 1.5 0.6 -0.0 0.5 0.0 0.7 1.3 1.5 0.9 1.5
Age at last live birth 0.6 0.9 4.2 -0.8 0.8 0.3 -0.4 0.4 0.0 1.3 0.7 0.9 1.2 2.1
Family relationship satisfaction 0.6 0.8 2.6 -0.9 0.9 1.6 -0.0 0.6 0.0 1.1 0.8 1.0 0.6 -0.6
Leg pain on walking 1.1 1.4 4.3 -1.5 1.5 -2.1 -0.1 0.5 0.0 0.5 1.5 1.6 0.6 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.8 -0.8 0.5 -0.2 1.7 1.1 0.0 1.1 0.8 0.7 0.6 -0.2
Commuting to job workplace: Car/motor vehicle 0.3 0.3 2.0 -0.2 0.2 0.9 0.2 1.4 0.0 -0.4 0.3 0.1 0.0 -0.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 0.8 -0.8 -0.3 -1.4 -0.8 0.0 -1.4 -0.8 -0.7 -0.6 -1.1
Medication: Aspirin 1.1 1.4 4.9 1.2 -0.9 -0.9 -2.2 -1.4 0.0 -1.6 -1.3 -0.9 -0.5 0.4
Supplements: Vitamin C 2.3 2.7 10.9 -1.2 0.9 0.8 3.3 1.9 0.0 2.6 1.5 0.9 1.4 -0.4
Knee pain experienced in last month 0.6 1.0 4.8 0.8 -0.5 0.5 -2.2 -2.0 0.0 -0.2 -0.7 -0.6 -0.5 0.3
Hypertension (Self-reported) 0.6 1.6 7.1 1.2 -1.2 -1.4 0.6 -0.6 0.0 -0.8 -1.1 -1.2 -1.4 -2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.9 -1.1 1.6 0.5 -1.7 0.3 0.0 0.1 1.0 1.3 0.9 0.6
Illnesses of father: Heart disease 1.0 1.3 5.2 -0.7 0.6 2.3 2.0 0.9 0.0 0.9 0.6 0.5 1.3 0.9
Illnesses of siblings: Diabetes 0.3 0.4 2.0 -0.3 0.3 -1.4 -0.5 0.5 0.0 -0.1 0.4 0.3 -0.5 -1.2
Smoking status: Previous 0.3 0.4 1.8 0.3 -0.4 -0.2 1.4 0.3 0.0 -0.6 -0.3 -0.4 -0.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 19.6 -1.1 1.3 -1.0 -4.4 0.5 0.0 -0.5 0.8 1.4 0.6 1.7
Whole body fat-free mass 2.1 11.9 43.2 2.9 -2.3 -3.7 -6.6 -3.3 0.0 -3.4 -2.5 -2.5 -3.5 -3.7
Leg fat-free mass (right) 2.1 11.0 19.9 3.1 -2.7 -4.3 -4.5 -3.3 0.0 -2.9 -2.8 -2.9 -4.0 -3.7
Arm fat percentage (left) 0.4 1.5 6.9 0.7 -0.6 -1.3 2.6 -0.6 0.0 -0.3 -0.7 -0.9 -1.5 -1.7
Average weekly red wine intake 0.0 0.0 0.1 0.0 -0.1 0.1 -0.2 0.0 0.0 -0.2 -0.3 -0.1 0.3 -0.3
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.0 0.9 -1.2 -1.7 1.4 -0.8 0.0 -0.7 -1.2 -1.0 -0.7 -0.7
Mood swings 0.3 0.6 2.2 -0.8 0.8 1.5 0.0 0.9 0.0 0.7 0.8 0.9 -0.6 0.1
Loneliness, isolation 0.5 0.7 5.3 -0.7 0.4 2.3 -0.3 0.2 0.0 0.7 0.5 0.8 -0.0 -0.1
Long-standing illness, disability or infirmity 1.5 2.4 4.9 -2.0 2.2 -0.4 0.4 2.1 0.0 1.6 2.0 2.1 0.9 0.9
Ever had bowel cancer screening 1.8 2.1 3.4 1.8 -1.8 -1.3 0.4 -1.8 0.0 -0.1 -1.9 -1.8 -1.7 -1.4
Diabetes diagnosed by doctor 0.4 0.7 3.3 0.4 -0.5 -1.8 -0.3 -1.0 0.0 -0.4 -0.4 -0.4 -1.4 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.0 -0.7 0.7 1.1 0.3 0.7 0.0 0.4 0.7 0.7 1.4 0.9
Friendships satisfaction 0.5 0.7 5.0 0.5 -0.4 -0.7 -2.2 -1.1 0.0 -0.2 -0.4 -0.2 -0.3 -0.2
Qualifications: nursing, teaching 0.3 0.5 1.1 0.7 -0.5 -0.5 -1.1 -1.0 0.0 -0.5 -0.8 -0.6 0.4 1.1
Commuting to job workplace: Walk 0.6 0.6 3.8 0.6 -0.6 -2.0 -0.7 -0.9 0.0 -0.2 -0.5 -0.5 -0.8 0.1
Eye problems/disorders: Cataract 0.3 0.3 0.9 0.1 -0.4 0.4 -0.9 0.9 0.0 -0.1 0.1 0.1 -0.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.0 1.0 -0.7 -0.9 -0.1 1.0 0.0 -0.3 -0.8 -0.9 -0.9 -1.0
Medication for cholesterol 0.2 0.4 3.1 0.1 -0.1 1.7 0.7 0.0 0.0 0.6 -0.0 -0.1 -0.1 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 2.4 -0.0 0.5 0.1 -1.5 0.9 0.0 -0.9 0.1 0.1 0.4 -0.4
Back pain experienced in last month 2.1 3.1 8.7 -2.3 2.2 0.6 0.5 2.9 0.0 1.1 2.3 2.3 1.3 0.2
Mineral and other dietary supplements 0.4 0.5 1.9 0.6 -0.5 -1.2 -0.5 -0.1 0.0 -1.4 -0.8 -0.6 -0.1 0.8
Breast cancer (self-reported) 0.8 1.0 2.5 -1.1 1.1 0.5 0.9 0.7 0.0 1.6 1.2 1.1 0.8 1.1
Asthma (self-reported) 0.3 0.7 2.6 0.9 -0.6 -1.3 -0.1 -1.6 0.0 0.1 -0.6 -0.9 -0.6 -0.8
Osteoporosis (self-reported) 1.0 1.2 3.7 -0.6 0.7 1.9 -0.1 1.3 0.0 0.8 0.5 0.6 1.4 1.9
Osteoarthritis (self-reported) 0.2 0.2 0.8 -0.2 0.7 -0.0 -0.9 -0.2 0.0 0.7 0.4 0.4 -0.0 0.4
Medication: Aspirin 1.2 1.6 5.4 1.2 -0.9 -0.5 -2.3 -1.6 0.0 -1.8 -1.4 -1.0 -0.6 0.2
Medication: Gliclazide 0.9 1.0 3.8 0.7 -0.7 -2.0 0.7 -1.0 0.0 -0.7 -0.7 -0.8 -1.5 -1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 1.1 0.1 -0.1 -1.0 0.2 0.3 0.0 -0.4 -0.3 -0.1 -0.6 -0.4
Smoking status: Current 4.4 6.9 12.8 -3.4 3.4 1.1 0.6 3.6 0.0 2.7 3.3 3.5 2.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.4 0.8 -1.1 -1.8 1.2 -0.0 0.0 -1.6 -1.1 -1.0 -1.2 -0.6
Whole body water mass 2.1 11.8 42.1 2.8 -2.2 -3.8 -6.5 -3.3 0.0 -3.3 -2.4 -2.4 -3.5 -3.7
Leg predicted mass (right) 2.1 11.3 20.3 3.2 -2.8 -4.4 -4.5 -3.4 0.0 -3.0 -2.8 -2.9 -4.0 -3.7
Arm fat mass (left) 0.6 2.4 6.4 1.4 -1.1 -2.3 -0.0 -1.3 0.0 -1.2 -1.2 -1.4 -2.2 -2.5
Number of self-reported non-cancer illnesses 0.7 1.3 2.4 -1.4 1.6 0.5 1.0 0.4 0.0 1.5 1.3 1.5 1.0 0.9
Average weekly champagne plus white wine intake 1.1 1.6 3.5 1.5 -1.1 -0.7 -1.2 -1.9 0.0 -0.6 -1.7 -1.5 -1.5 -0.6
Miserableness 1.1 1.9 4.4 -1.8 1.8 2.1 1.0 1.6 0.0 1.0 1.7 1.8 0.1 -0.2
Guilty feelings 1.9 2.8 5.2 -2.2 2.3 0.8 0.2 2.2 0.0 1.8 2.1 2.3 1.4 0.8
Wears glasses or contact lenses 0.2 0.3 0.8 0.0 -0.0 -0.9 0.6 0.5 0.0 -0.7 -0.1 -0.1 0.5 0.8
Ever taken oral contraceptive pill 0.4 0.5 2.5 -0.3 0.5 1.6 0.2 -0.2 0.0 0.5 0.2 0.3 1.2 0.7
Hearing aid user 0.7 0.8 2.8 0.3 -0.3 -1.7 1.6 1.0 0.0 -0.6 -0.3 -0.5 -0.8 -0.7
Mother’s age at death 0.1 0.1 0.6 0.3 -0.3 0.0 0.4 0.7 0.0 -0.1 -0.4 -0.3 -0.5 -0.3
Financial situation satisfaction 2.4 3.0 6.8 -2.0 2.2 1.1 0.9 2.6 0.0 2.0 2.1 1.9 1.7 0.9
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.4 -0.6 0.5 0.3 0.3 0.7 0.0 1.2 0.7 0.7 0.2 0.1
Commuting to job workplace: Public transport 1.3 1.6 3.6 1.6 -1.8 -0.2 0.0 -1.9 0.0 0.2 -1.6 -1.5 -1.3 -1.3
Eye problems/disorders: Glaucoma 0.2 0.2 0.6 0.5 -0.1 0.5 -0.7 -0.3 0.0 -0.1 -0.5 -0.4 -0.5 -0.8
Medication: Blood pressure 0.4 0.8 2.6 0.8 -0.8 -1.3 -0.0 -0.6 0.0 -0.8 -0.7 -0.8 -0.9 -1.6
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.7 -1.8 1.8 0.5 0.3 1.4 0.0 1.3 1.9 1.8 0.5 0.4
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.5 -0.3 0.3 0.7 0.1 -0.2 0.0 0.2 0.5 0.3 0.0 -0.7
High cholesterol (Self-reported) 0.2 0.4 0.9 -0.8 0.9 -0.2 -0.4 0.4 0.0 0.5 0.8 0.8 0.6 0.8
Medication: Bendroflumethiazide 0.1 0.2 0.7 0.4 -0.5 -0.2 0.8 0.4 0.0 0.4 -0.6 -0.4 0.0 0.2
Medication: Paracetamol 7.2 11.1 18.9 -4.2 4.2 3.2 0.8 3.9 0.0 2.8 4.3 4.2 3.4 2.0
Medication: Lisinopril 0.2 0.2 0.9 0.2 -0.3 -0.9 0.6 0.1 0.0 0.6 -0.2 -0.3 -0.4 -0.8
Medication: Atorvastatin 0.8 1.0 2.1 -1.2 1.2 0.4 0.9 1.4 0.0 1.4 1.2 1.2 0.7 0.4
Illnesses of father: High blood pressure 0.5 0.6 2.4 0.3 -0.5 1.3 1.0 -0.2 0.0 0.7 0.1 -0.4 -0.2 -1.6
Alcohol drinker status: Never 0.8 1.0 2.4 -1.1 1.4 1.6 -0.3 1.0 0.0 0.4 1.4 1.2 -0.0 -0.9
Ever smoked 0.2 0.3 1.7 -0.2 0.1 -0.4 1.3 1.1 0.0 -0.1 0.2 0.2 -0.0 -0.7
Basal metabolic rate 2.0 11.2 36.8 2.8 -2.2 -3.8 -6.1 -3.3 0.0 -3.4 -2.5 -2.4 -3.5 -3.5
Leg fat percentage (left) 0.1 0.3 1.1 0.0 0.2 -0.6 1.1 0.1 0.0 -0.5 -0.1 -0.1 -0.5 -1.0
Arm fat-free mass (left) 1.9 9.6 38.4 2.4 -1.9 -3.6 -6.2 -2.8 0.0 -3.0 -2.0 -2.1 -2.9 -3.4
Number of operations (self-reported) 2.8 4.2 8.1 -2.5 2.5 1.7 0.2 2.4 0.0 2.0 2.8 2.5 2.2 1.1
Average weekly beer plus cider intake 1.2 1.8 6.1 -1.3 1.5 0.1 2.5 1.2 0.0 1.6 1.5 1.1 0.7 1.3
Irritability 0.7 1.2 2.3 -1.5 1.3 -0.8 1.0 1.4 0.0 0.8 1.3 1.5 0.4 0.7
Risk taking 0.3 0.4 1.5 -0.5 0.3 -0.2 0.6 1.1 0.0 1.2 0.5 0.5 0.6 -0.3
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.4 1.8 -1.8 0.3 -1.8 -1.7 0.0 -1.1 -1.7 -1.7 -1.1 -0.3
Fractured/broken bones in last 5 years 0.2 0.3 2.7 0.0 -0.0 1.6 0.0 -0.1 0.0 0.3 -0.0 -0.1 0.3 0.3
Age started oral contraceptive pill 1.3 1.6 2.9 1.4 -1.0 -1.2 -1.6 -1.0 0.0 -1.7 -1.6 -1.3 -0.4 -1.5
Diastolic blood pressure, automated reading 0.3 0.9 3.0 0.8 -0.6 -1.7 0.9 -0.7 0.0 0.1 -0.5 -0.8 -0.9 -1.6
Ever depressed for a whole week 0.4 0.5 1.2 -1.0 0.9 -0.2 0.1 0.5 0.0 0.9 1.1 1.1 0.3 0.2
Unable to work because of sickness or disability 0.7 0.9 4.7 0.6 -0.5 -0.9 -0.3 -0.3 0.0 -2.2 -0.8 -0.6 -1.1 -1.0
Commuting to job workplace: Cycle 0.1 0.2 0.5 -0.3 0.2 0.7 -0.4 0.4 0.0 -0.4 0.2 0.4 0.6 -0.2
Myopia 0.8 1.1 8.6 0.5 -0.3 0.1 0.8 -1.0 0.0 0.4 -0.7 -0.5 -0.6 2.9
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.1 -0.8 0.8 1.4 0.0 0.5 0.0 1.1 0.8 0.7 1.0 1.8
Cholesterol lowering medication 0.6 0.8 2.5 -0.9 1.1 -1.0 -1.6 -0.1 0.0 0.1 1.0 1.1 0.9 0.7
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 6.1 -0.6 1.0 -0.5 -2.5 0.1 0.0 -0.9 0.6 0.8 0.8 0.5
Pain experienced in last month 0.4 0.6 1.7 1.1 -1.0 -0.1 0.5 -1.3 0.0 -0.3 -1.2 -1.1 0.2 0.1
Supplements: Calcium 2.7 3.0 7.2 -1.6 1.7 2.2 0.9 2.4 0.0 2.7 1.4 1.6 1.9 0.8
Basal cell carcinoma (self-reported) 0.2 0.2 0.9 0.2 -0.1 -0.6 -1.0 0.2 0.0 -0.5 -0.1 -0.2 -0.3 -0.8
Heart attack/myocardial infarction (self-reported) 1.9 2.5 6.1 -1.7 1.9 2.0 0.9 2.5 0.0 1.2 1.7 1.7 1.1 1.1
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 5.3 -2.0 1.9 0.6 -0.6 1.4 0.0 1.5 1.9 2.1 1.7 2.3
Heart disease (siblings) 0.4 0.5 2.1 0.5 -0.1 1.0 -1.5 -0.9 0.0 -0.4 -0.6 -0.3 -0.2 -1.0
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.1 0.0 0.2 -0.0 0.2 0.0 0.5 0.4 0.1 -0.5 -0.4
Pack years of smoking 0.4 0.6 4.2 -0.5 0.6 -0.8 -2.1 -0.2 0.0 -0.6 0.5 0.6 0.7 -0.0
Impedance of whole body 0.5 2.6 10.5 -0.2 0.2 2.1 -2.5 0.6 0.0 -1.4 -0.3 0.4 2.1 3.2
Leg fat mass (left) 0.5 1.9 4.5 1.1 -0.8 -2.1 -0.8 -1.1 0.0 -1.5 -1.1 -1.1 -1.9 -2.0
Arm predicted mass (left) 2.1 10.6 40.1 2.7 -2.1 -3.7 -6.3 -2.7 0.0 -3.3 -2.3 -2.3 -3.2 -3.6