Best TWAS P=5.73e-10 · Best GWAS P=2.78e-09 conditioned to 0.962
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PTPRJ | 0.05 | 0.05 | lasso | 2 | 0.04 | 3.9e-04 | 5.7 | 5.4 | 6.2e-08 | 0.59 | 0.01 | 0.96 | TRUE |
| 2 | GTEx | Artery Aorta | MADD | 0.09 | 0.03 | enet | 22 | 0.04 | 1.9e-03 | -5.9 | 6.2 | 5.7e-10 | 0.45 | 0.01 | 0.92 | TRUE |
| 3 | GTEx | Artery Aorta | PACSIN3 | 0.10 | 0.04 | lasso | 4 | 0.03 | 1.1e-02 | 3.8 | 5.4 | 8.0e-08 | 0.45 | 0.28 | 0.27 | FALSE |
| 4 | GTEx | Prostate | PSMC3 | 0.21 | 0.10 | lasso | 6 | 0.20 | 7.9e-06 | 4.7 | -5.5 | 4.4e-08 | -0.56 | 0.12 | 0.22 | FALSE |
| 5 | NTR | Blood | MADD | 0.01 | 0.01 | enet | 8 | 0.01 | 4.7e-03 | 5.0 | 5.9 | 3.8e-09 | 0.31 | 0.11 | 0.37 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CELF1 | 0.03 | 0.01 | bslmm | 289 | 0.01 | 2.9e-02 | 5.3 | 6.2 | 6.9e-10 | 0.83 | 0.04 | 0.77 | FALSE |