Hub : Genes

PTPRJ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0260 7.2e-07 0.045 0.048 0.036 0.046 0.051 3.5e-06 1.7e-06 3.2e-05 2.6e-06 7.6e-07
2 GTEx Adipose Subcutaneous 0.0520 0.0320 5.6e-03 0.049 NA 0.023 NA 0.039 7.4e-05 NA 5.4e-03 NA 3.9e-04
3 GTEx Nerve Tibial 0.0505 0.0274 3.9e-03 0.028 NA 0.031 NA 0.023 4.4e-03 NA 2.8e-03 NA 9.3e-03
4 GTEx Spleen 0.2180 0.1060 7.0e-03 0.051 NA -0.011 NA 0.025 1.9e-02 NA 8.0e-01 NA 7.5e-02
5 NTR Blood 0.0352 0.0155 1.5e-06 0.011 0.022 0.011 0.022 0.013 1.1e-04 8.5e-08 1.3e-04 9.5e-08 3.9e-05
6 YFS Blood 0.0167 0.0122 7.6e-04 0.012 0.013 0.016 0.016 0.014 6.2e-05 4.0e-05 3.4e-06 2.8e-06 1.7e-05
7 TCGA Prostate Adenocarcinoma 0.0416 0.0223 6.7e-03 0.018 0.020 0.020 NA 0.026 5.4e-03 2.9e-03 3.3e-03 NA 9.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.3 2.0 5.1 0.7 -0.0 -0.2 1.6 2.0 -1.4 -2.3
Bipolar Disorder or Schizophrenia 0.9 2.2 8.0 0.2 0.1 -0.3 2.8 2.4 -0.1 -1.2
Depressed Affect (Nagel 2018) 2.6 5.5 24.1 -1.8 1.1 2.1 4.9 -1.4 0.8 1.6
Depression (Nagel 2018) 1.4 2.1 4.9 0.6 0.8 2.2 2.2 0.9 1.7 0.5
Intelligence (Savage-Jansen 2018) 1.9 5.8 14.1 1.8 1.9 3.8 0.5 2.4 1.8 -3.2
Neuroticism (Nagel 2018) 1.9 4.6 17.3 -1.4 1.5 2.7 4.2 -1.4 0.8 0.4
Schizophrenia (2018) 0.6 1.3 5.5 -0.3 0.1 -0.2 2.3 1.5 1.0 0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 0.1 0.4 0.9 -0.7 -0.9 0.5 1.0
Worry (Nagel 2018) 1.5 3.2 11.2 0.1 1.4 2.8 3.3 0.1 0.7 -0.9
Alzheimer’s Disease (in mother) 0.3 0.4 1.5 0.2 -0.7 -0.1 1.2 0.7 0.1 -0.4
Alzheimer’s Disease (in father) 2.4 2.6 7.8 1.2 2.5 2.8 0.0 -0.4 1.4 0.3
Alzheimer’s Disease (including proxy) 1.0 1.4 5.4 0.9 1.3 2.3 1.3 -0.0 0.5 -0.3
Crohns Disease (2017) 1.1 2.4 6.1 -1.6 -2.5 -1.8 0.8 -1.4 -0.5 1.5
Irritable Bowel Disease (IBD) 1.5 3.5 10.8 -1.8 -3.3 -2.0 0.2 -1.4 -1.0 1.7
Ulcerative Colitis (UC) 1.0 1.8 5.6 -1.2 -2.4 -1.3 -0.3 -0.9 -0.9 1.5
Major Depression (MDD) 3.6 4.3 11.8 0.3 0.9 3.1 3.4 -0.2 2.8 0.2
Reaction Time 1.6 3.1 12.3 2.4 0.2 -0.8 -0.5 3.5 -0.1 -1.7
Verbal and Numeric Reasoning (VNR) 2.4 5.8 15.9 2.0 2.5 4.0 0.3 2.2 2.1 -2.3
Breast Cancer 0.8 1.9 8.5 -1.5 -1.1 -0.4 2.9 -0.9 0.6 0.2
Ovarian Cancer 1.1 1.5 3.9 0.9 1.4 1.2 -2.0 -0.6 0.3 1.3
Prostate Cancer 0.2 0.3 0.7 0.2 -0.9 0.6 -0.8 -0.1 -0.0 -0.3
Age at First Birth 0.8 1.2 3.3 -0.4 -1.8 -1.7 -0.3 0.3 -1.1 -0.7
Bipolar Disorder (2011) 1.8 1.8 5.1 1.3 0.5 0.6 1.7 2.2 0.6 -1.4
Body Mass Index (BMI) (2010) 1.9 2.5 5.6 -0.2 0.7 -1.9 2.4 1.3 2.2 -1.1
Coronary Artery Disease (CAD) 2.4 2.9 7.2 -0.7 -1.9 -2.7 1.4 1.4 -1.9 -1.3
Crohns Disease (2012) 1.2 1.9 6.2 -1.4 -2.5 -1.9 0.0 -0.8 -0.9 -0.1
Mean Putamen Volume 2.1 2.4 5.7 -1.3 -1.7 -2.4 2.3 0.9 -0.5 -0.7
Fasting Glucose 4.9 5.9 11.7 3.0 2.2 1.8 0.5 3.4 2.5 -2.4
HbA1C 0.5 0.5 1.2 -0.3 -0.9 -0.1 -1.0 -0.7 -1.1 -0.4
HDL Cholesterol 13.0 21.7 47.5 6.9 4.1 5.3 0.1 5.7 4.3 -2.7
LDL Cholesterol 0.3 0.5 1.4 0.4 -0.5 -0.0 0.8 1.2 -0.1 -1.2
Lupus 0.8 1.2 2.3 1.1 1.4 1.5 -0.9 0.8 1.2 0.4
Neuroticism (2016) 1.8 2.6 6.2 -1.0 1.5 2.5 2.1 -1.9 0.1 0.9
Primary Biliary Cirrhosis 0.2 0.3 0.7 -0.7 0.1 0.2 0.5 0.8 -0.4 -0.6
Rheumatoid Arthritis 1.0 1.4 5.5 1.2 -0.0 -0.5 -2.3 -0.7 0.1 1.4
Schizophrenia (2014) 0.6 1.4 5.8 -0.2 0.2 0.2 2.4 1.6 0.7 -1.0
Triglycerides 0.6 1.0 2.1 -0.7 1.0 0.3 1.4 -1.1 0.9 1.3
Type 2 Diabetes (T2D) (2012) 1.6 1.9 9.9 -0.6 0.7 -0.7 3.1 0.7 1.2 -0.2
Ulcerative Colitis 1.8 2.6 9.4 -0.7 -3.1 -2.0 -1.3 -0.2 -1.5 -0.1
Blood Eosinophil Count 1.5 11.3 23.6 -3.8 -3.7 -3.6 -1.0 -4.9 -3.4 1.3
Blood Platelet Count 0.5 6.3 19.4 -0.9 -1.3 2.9 -4.4 -0.8 -3.6 -0.6
Blood Red Count 0.5 4.4 22.5 1.7 -0.0 -0.7 -4.7 0.2 -0.7 2.2
Blood White Count 6.6 49.3 75.0 -6.6 -8.6 -8.7 -6.3 -7.4 -7.1 2.8
Heel T-Score 1.8 14.7 34.7 4.8 -3.4 -2.8 -5.9 4.4 -2.3 -1.0
BMI 1.2 7.1 24.0 -2.6 -0.7 -4.9 3.7 0.4 1.9 -0.9
Height 3.9 75.9 148.8 8.3 11.7 12.2 6.5 8.4 7.8 -2.1
Waist Hip Ratio (WHR) 3.4 15.3 34.7 5.0 4.4 2.1 2.0 5.9 3.4 -2.9
Systolic Blood Pressure 9.9 49.6 141.6 -11.9 -7.4 -4.8 6.4 -6.5 -6.5 1.4
Smoking Status 1.8 4.2 12.2 2.7 0.3 1.4 1.8 3.5 0.5 -2.1
Allergy or Eczema 0.3 0.9 4.8 -0.6 0.7 -0.1 2.2 -0.1 0.5 -0.5
Cardiovascular Disease 6.3 20.8 53.9 -7.3 -3.7 -4.6 6.7 -2.5 -2.0 1.3
Hypothyroidism (self reported) 0.7 1.7 4.6 -1.2 -1.2 -2.2 -0.3 -0.7 -0.5 1.8
Respiratory disease 0.7 1.6 4.8 -1.8 0.8 0.2 2.2 -0.2 0.5 -1.5
Type 2 Diabetes (T2D) (2018) 1.9 3.5 9.3 0.9 1.2 -0.2 3.1 2.2 2.3 -1.6
Lung FEV1/FVC ratio 0.1 0.5 1.5 0.2 0.2 -0.7 -1.2 0.4 -0.9 0.4
Lung FVC 0.5 2.3 8.2 -0.1 -1.1 1.1 -2.9 -1.4 -1.5 1.2
Neuroticism 1.7 4.1 16.2 -1.0 1.7 2.8 4.0 -0.3 0.3 -0.3
Chronotype (morning person) 2.2 5.1 17.3 -2.9 -0.5 -2.4 4.2 -0.5 1.5 1.3
Hair Pigment 0.2 5.6 15.7 3.1 -0.9 0.7 -1.5 4.0 -1.1 -3.0
Tanning 0.1 0.9 1.8 -0.9 0.4 1.3 1.0 -1.2 -0.9 -0.2
Hand grip strength (left) 1.7 4.5 13.2 0.2 1.8 3.6 -1.5 -1.9 -1.2 2.8
Number of treatments/medications taken 2.4 4.4 12.5 -2.0 -1.4 -3.0 3.5 1.1 -0.8 -1.0
Average weekly spirits intake 0.7 0.9 3.0 -0.7 -0.7 -0.8 -0.7 -0.7 -0.7 1.7
Sensitivity / hurt feelings 0.4 0.7 2.3 -1.3 0.5 0.4 1.5 -0.5 0.0 -0.2
Frequency of depressed mood in last 2 weeks 1.4 1.9 4.8 -0.0 0.5 2.0 2.2 -0.4 1.2 1.6
Hearing difficulty/problems: Yes 1.3 2.0 4.9 -0.3 0.5 0.8 -1.9 -2.1 0.5 2.2
Relative age of first facial hair 0.6 1.2 2.4 1.3 1.3 1.5 0.4 0.8 1.2 0.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 -0.6 0.0 -0.5 1.0 0.9 -0.7 0.1
Ever used hormone-replacement therapy (HRT) 2.3 2.9 6.1 -1.1 -1.4 -2.5 -2.2 -1.1 -2.2 0.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.4 -0.1 0.3 -0.8 -0.9 -1.2 -0.2 0.9
Systolic blood pressure, automated reading 6.4 18.6 50.0 -7.1 -4.9 -3.8 2.8 -3.8 -4.4 0.7
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 4.1 -1.2 -0.7 -2.0 1.2 0.5 -0.2 -0.6
Angina 2.5 3.3 7.4 -2.1 -2.2 -2.7 2.4 -0.1 -0.3 -0.5
Medication for hormone replacement therapy 1.5 1.7 4.9 -0.8 -1.9 -1.0 -2.2 -0.1 -1.2 -0.4
Vitamin and mineral supplements 0.3 0.4 2.0 -0.6 -0.1 0.5 1.4 -0.1 0.5 0.2
Supplements: Zinc 1.2 1.3 4.0 0.9 0.3 0.8 -2.0 -0.1 -1.5 -1.1
Medication: Co-codamol 0.6 0.7 1.5 0.8 0.8 0.4 1.0 -0.1 1.2 0.9
Medication: Metformin 4.1 5.8 14.7 1.4 3.1 1.0 3.2 1.7 3.8 -0.9
Diabetes (father) 0.6 0.7 2.2 -1.2 -0.1 -1.5 0.8 -0.2 -0.2 -0.8
Diabetes (mother) 1.1 1.4 3.0 0.6 1.2 0.9 1.7 1.5 1.2 -0.8
Severe depression (siblings) 2.8 3.1 8.2 2.0 2.5 2.9 0.1 0.9 1.6 -0.8
Pack years adult smoking proportion 0.9 1.3 5.7 0.4 -0.1 0.1 2.4 1.5 1.0 0.2
Impedance of leg (right) 0.2 1.1 2.5 0.3 -1.2 1.4 -1.2 -1.6 -0.7 -0.0
Leg fat-free mass (left) 1.9 10.0 20.4 1.6 4.5 1.8 4.1 3.5 3.7 -0.5
Trunk fat percentage 2.0 7.9 26.9 -1.4 -1.3 -5.2 3.9 2.4 1.6 -1.1
Hand grip strength (right) 1.0 2.6 9.1 -0.4 1.4 3.0 -0.2 -1.9 -0.3 1.8
Townsend deprivation index at recruitment 2.2 3.1 7.2 0.8 1.3 2.0 2.7 1.5 1.7 -1.7
Current tobacco smoking 1.2 2.0 6.4 1.1 0.7 2.5 1.8 0.8 1.1 1.1
Average weekly fortified wine intake 1.5 1.8 9.4 1.1 0.3 0.5 -3.1 -0.6 -1.1 0.2
Maternal smoking around birth 0.8 1.1 3.5 -1.9 -0.3 -1.0 1.6 -0.7 0.2 0.5
Fed-up feelings 2.0 3.6 11.4 -2.0 0.0 0.1 3.4 -1.9 0.4 2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.8 -0.4 -0.1 0.9 1.7 0.3 0.1 0.1
Relative age voice broke 0.2 0.4 0.9 0.4 -0.6 0.0 -0.9 -0.1 -0.5 0.9
Taking other prescription medications 1.3 2.0 6.5 -0.8 -0.3 -1.8 2.5 1.3 0.3 -1.4
Age when periods started (menarche) 2.5 5.9 18.8 3.1 3.0 4.3 -1.6 0.6 0.8 0.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.3 -1.4 -0.6 -0.1 -0.0 -1.5 0.7 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 11.5 2.7 -0.7 -1.1 -1.6 3.4 -0.8 -2.2
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.1 -1.4 -1.5 -1.3 0.2 -0.9 -2.0 0.3
Qualifications: CSEs or equivalent 1.7 2.2 4.8 -0.6 1.5 1.7 2.2 -0.5 2.2 0.1
Serious illness, injury or assault to yourself 0.6 0.7 1.2 -0.9 -1.0 -1.0 1.1 -0.8 0.4 0.3
High blood pressure 10.0 28.0 67.4 -8.2 -5.3 -5.0 4.6 -5.4 -3.3 3.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.8 -0.9 -0.0 -0.1 1.9 -0.3 0.2 -0.5
Multivitamins +/- minerals 0.3 0.4 1.0 -0.0 0.3 0.2 -1.0 -0.7 -0.8 0.6
Stomach or abdominal pain in last month 1.9 2.4 6.3 0.1 1.9 1.7 2.5 -0.4 1.7 1.0
Supplements: Glucosamine 1.0 1.4 7.7 0.7 0.4 0.5 -2.8 -0.9 0.1 0.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.5 1.2 0.6 -0.1 0.9 1.9 0.9 -1.2
Medication: Atenolol 1.0 1.2 4.9 -0.5 -0.5 -0.4 -0.0 -1.6 -0.5 2.2
Medication: Levothyroxine sodium 1.6 2.8 5.6 -2.1 -1.8 -2.4 -0.5 -1.6 -1.5 1.1
Sitting height 1.8 12.9 33.5 1.2 4.6 5.8 5.0 1.7 2.6 -0.3
Chronic bronchitis/emphysema (father) 0.6 0.7 2.6 0.0 -0.1 -0.9 0.4 1.6 -0.7 -0.9
High blood pressure (mother) 2.2 3.1 10.1 -2.7 -0.8 -1.4 3.2 -0.8 -0.6 1.0
Body mass index (BMI) 1.3 5.4 22.2 -2.3 -1.1 -4.7 2.8 0.5 0.9 -0.4
Impedance of leg (left) 0.2 1.0 2.5 0.1 -1.6 1.0 -0.7 -1.4 -0.9 -0.0
Leg predicted mass (left) 1.8 9.7 20.0 1.6 4.5 1.7 4.1 3.5 3.7 -0.6
Trunk fat mass 1.7 7.5 22.7 -0.6 0.4 -3.5 4.8 3.0 2.6 -1.2
Waist circumference 1.8 6.4 14.9 0.6 1.7 -2.2 3.9 3.3 2.8 -1.8
Number of incorrect matches in round 1.7 2.8 7.4 2.7 0.9 0.1 -2.6 0.0 0.7 2.0
Past tobacco smoking 0.3 0.5 1.9 -1.4 -0.2 -0.6 0.3 -1.0 -0.6 -0.2
Alcohol usually taken with meals 0.3 0.6 1.3 0.5 0.6 0.3 -1.0 -1.1 0.1 1.0
Nervous feelings 1.4 2.5 11.4 -0.7 1.2 1.9 3.4 -0.1 0.4 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.6 -0.5 -0.1 1.2 1.9 -0.1 -0.0 0.6
Hearing difficulty/problems with background noise 3.5 5.7 16.5 -1.9 -0.3 0.8 -2.0 -4.1 -0.7 3.7
Hair/balding pattern: Pattern 2 0.6 0.7 3.2 0.6 -0.1 1.8 -0.5 0.2 0.0 -1.1
Had menopause 0.3 0.4 0.7 0.8 0.7 0.8 -0.4 0.6 -0.4 -0.0
Had other major operations 0.2 0.3 0.8 0.4 -0.0 0.5 -0.1 0.6 0.6 -0.9
Forced vital capacity (FVC) 2.2 8.3 29.7 2.6 3.6 5.5 0.3 1.1 2.5 1.0
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.0 15.4 3.3 -0.2 -1.2 -1.5 3.9 -0.9 -2.0
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 7.7 0.7 2.0 2.0 2.8 1.4 2.6 0.2
Qualifications: None of the above 0.3 0.6 2.4 -0.6 0.2 0.3 1.6 -0.9 0.8 0.2
Financial difficulties in last 2 years 0.9 1.2 2.4 -1.1 0.6 1.5 0.4 -1.4 0.1 1.6
Mouth/teeth dental problems 1.1 1.7 5.2 -0.4 -0.5 -0.9 -1.5 0.5 -2.3 -1.7
Heart attack 1.7 2.2 9.9 -0.4 0.8 -0.6 3.1 1.6 0.6 -1.2
Allergy 0.8 1.8 6.6 1.4 -0.5 0.5 -2.6 -0.3 0.1 1.8
Pain all over the body in last month 0.5 0.5 1.2 -0.7 0.4 -1.1 1.0 0.0 -0.3 0.8
Diabetes (self-reported) 1.0 1.6 3.8 0.2 0.2 -1.0 1.8 2.0 1.3 -1.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.0 -0.7 0.2 -0.3 0.7 -1.4 1.2 1.7
Medication: Ramipril 2.6 3.3 9.3 -2.6 -1.2 -1.7 3.0 -0.4 -1.6 -0.6
Medication: Simvastatin 1.0 1.4 3.8 -1.0 -0.9 -2.0 0.4 0.8 -1.9 -0.1
Fluid intelligence score 3.0 6.2 15.6 1.9 2.6 3.9 1.6 1.9 2.8 -1.8
Illnesses of siblings 2.3 3.2 8.9 3.0 2.1 2.1 -1.2 1.7 0.6 -0.2
Neuroticism score 2.3 4.7 16.5 -0.5 1.7 3.2 4.1 -0.6 1.2 1.0
Weight 1.8 9.1 25.3 0.9 3.2 0.1 5.0 3.4 3.8 -0.9
Impedance of arm (right) 0.2 1.0 2.1 0.8 -1.4 -1.4 -0.6 1.2 -0.6 -0.3
Arm fat percentage (right) 2.1 8.3 37.0 -2.3 -2.1 -6.1 3.0 1.2 0.7 -0.6
Trunk fat-free mass 3.6 20.5 45.8 3.5 6.8 5.9 3.9 3.7 4.5 -0.9
Hip circumference 0.8 3.6 13.8 -1.6 0.5 -2.1 3.7 0.6 1.8 -0.6
Time employed in main current job 0.5 0.6 1.6 0.5 -0.0 0.3 0.6 1.2 0.6 -1.3
Alcohol intake versus 10 years previously 0.4 0.7 1.7 1.3 0.7 0.2 -0.4 0.8 1.3 -0.4
Father’s age at death 0.6 0.9 2.9 1.2 0.7 0.4 -1.7 -0.1 -0.8 -0.5
Worrier / anxious feelings 1.4 2.7 6.4 1.2 2.0 2.5 2.0 0.7 1.2 -1.1
Frequency of tiredness / lethargy in last 2 weeks 3.4 5.6 15.4 -0.0 3.1 3.0 3.9 0.5 2.1 0.6
Falls in the last year 1.6 2.1 6.1 -2.5 -1.1 -0.8 2.4 -0.4 -0.6 -0.8
Hair/balding pattern: Pattern 3 0.7 1.1 2.4 -1.4 0.5 -0.5 0.8 -1.6 0.6 1.3
Number of live births 1.8 2.6 4.1 -1.8 -1.5 -1.1 -1.7 -2.0 -1.7 0.9
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 15.5 1.4 2.5 3.9 -0.2 0.5 1.3 0.4
Pulse rate 0.9 1.5 4.0 0.1 0.5 -0.4 1.4 2.0 0.0 -2.0
Happiness 0.3 0.4 1.3 0.3 -0.4 -0.4 0.1 1.2 -0.9 0.2
Noisy workplace 0.8 1.0 4.2 -0.7 0.3 -1.0 2.0 -0.2 -0.5 0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.4 1.7 0.4 0.6 -2.1 0.9 -0.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.3 -0.3 0.5 -0.3 1.8 -0.1 0.3 1.7
Mouth/teeth dental problems: Dentures 1.4 2.3 5.2 2.1 1.4 1.8 -0.2 1.1 2.3 0.6
Asthma 0.9 1.7 5.9 -2.4 -0.4 -1.0 1.4 -0.8 -1.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.1 0.5 -1.4 -1.1 -1.5 0.3 -1.1 -0.9
Medication: Cholesterol lowering 0.6 0.9 3.4 -0.6 0.2 -0.9 1.8 1.3 0.4 -0.3
Depression (self-reported) 2.2 2.6 7.2 -0.2 0.5 0.7 2.6 1.9 0.7 -2.7
Medication: Lansoprazole 0.3 0.3 1.0 -0.2 -0.2 -0.4 1.0 0.6 0.3 0.6
Prospective memory result 0.8 1.0 3.1 -1.8 -0.3 -0.7 0.8 -1.3 -0.2 0.9
Lung cancer (father) 3.4 4.0 9.3 2.1 2.3 3.0 1.0 1.2 2.4 0.6
Illnesses of mother 1.7 2.1 9.6 1.9 0.5 0.5 -3.1 0.2 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 14.8 1.9 1.9 3.9 -1.2 0.9 0.5 -0.3
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -0.4 -0.4 -1.4 0.1 0.5 -1.3 0.5
Impedance of arm (left) 0.2 1.1 2.6 0.5 -1.5 -1.6 -0.4 1.4 -0.5 -0.6
Arm fat mass (right) 1.4 5.6 15.5 -1.5 0.0 -3.8 3.9 1.8 1.9 -0.5
Trunk predicted mass 3.5 20.1 45.2 3.5 6.7 5.9 3.9 3.6 4.5 -0.8
Standing height 4.9 48.3 96.8 6.5 9.5 9.8 5.3 6.2 6.4 -0.9
Length of working week for main job 0.9 1.0 2.3 -0.9 -1.5 0.2 -1.4 -1.3 -0.0 0.3
Exposure to tobacco smoke at home 0.8 0.9 2.0 -0.3 1.0 0.1 0.9 -1.4 0.6 1.3
Breastfed as a baby 1.2 1.4 3.9 1.2 0.5 1.2 -0.0 2.0 0.1 -1.8
Tense / ‘highly strung’ 0.9 1.6 6.7 -1.7 -0.5 -0.1 2.6 -1.0 -0.5 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 5.4 0.6 1.4 2.2 2.3 1.2 1.1 -1.0
Hair/balding pattern: Pattern 4 2.0 4.8 14.0 -1.6 -2.8 -3.7 -0.7 0.3 -2.4 -1.6
Birth weight of first child 1.9 3.5 6.9 2.6 2.3 2.0 -0.6 1.1 1.7 2.1
Peak expiratory flow (PEF) 0.5 1.2 2.4 1.4 0.7 1.5 -1.1 1.0 -0.4 1.0
Pulse wave reflection index 1.6 2.0 5.7 -0.7 -0.6 -0.9 -1.6 -1.8 -0.8 2.4
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.3 0.3 0.5 0.7 1.8 1.2 1.3 -0.8
Loud music exposure frequency 1.0 1.1 2.1 -1.1 -0.4 -1.4 1.0 -1.3 0.7 1.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 4.0 1.1 0.4 0.3 0.7 2.0 1.0 -0.7
Mouth/teeth dental problems: Bleeding gums 1.3 1.6 4.8 -1.1 -0.5 -1.2 2.2 -0.9 0.2 1.6
Blood clot in the leg (DVT) 1.2 1.5 3.1 0.3 1.8 1.2 1.1 0.8 1.4 -1.4
Medication: Paracetamol 0.7 1.2 4.6 -0.8 -1.6 -2.2 0.4 0.4 -0.3 -0.0
Headache pain in last month 0.4 0.7 1.6 1.2 -0.5 0.1 -0.2 1.1 0.0 -1.3
Medication for cholesterol, blood pressure or diabetes 2.6 4.2 11.1 3.3 2.2 2.0 -2.7 1.0 0.5 -1.1
Glaucoma (self-reported) 4.7 5.6 10.2 3.2 2.4 2.1 1.5 3.0 2.5 -1.0
Gout (self-reported) 0.2 0.3 1.3 -0.6 0.3 -0.1 1.1 -0.1 0.2 0.5
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.3 -2.0 -1.4 -2.3 0.2 -1.0 -1.3 0.3
Medication: Amlodipine 3.9 5.5 11.9 -3.5 -2.3 -2.1 3.1 -1.8 -1.8 0.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.9 0.3 1.1 1.1 1.1 -0.7 1.4 0.5
Birth weight 1.5 3.2 7.2 2.1 2.2 2.7 1.2 2.0 0.6 0.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 1.1 -0.5 0.1 0.1 1.0 -0.1 0.6 -0.2
High blood pressure (siblings) 5.0 7.3 16.3 -4.0 -2.3 -2.5 1.3 -3.6 -1.5 2.4
Forced vital capacity (FVC), Best measure 1.7 6.3 26.5 2.6 2.7 5.2 -0.5 1.3 1.4 0.2
Body fat percentage 2.1 8.1 30.0 -2.2 -1.8 -5.5 3.8 1.4 1.4 -0.8
Leg fat percentage (right) 1.7 6.1 22.5 -2.7 -2.2 -4.7 2.7 -0.2 0.9 -0.7
Arm fat-free mass (right) 2.5 13.0 28.3 2.1 5.3 4.2 4.0 2.8 4.1 -0.7
Exposure to tobacco smoke outside home 1.4 1.8 9.5 -1.0 0.6 0.1 3.1 -0.4 1.3 0.0
Comparative body size at age 10 4.0 11.0 41.7 -3.6 -3.7 -6.5 2.6 0.6 -1.0 0.7
Number of full brothers 1.0 1.2 2.5 -1.2 -1.6 -0.8 -1.2 -0.8 -1.3 -0.2
Worry too long after embarrassment 0.4 0.7 2.7 -0.1 1.1 1.6 0.5 -0.5 -0.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.8 0.6 0.1 0.8 1.7 1.7 -0.1 -1.3
Wheeze or whistling in the chest in last year 0.9 1.7 7.5 -1.3 0.9 0.2 2.7 -0.6 1.1 0.6
Number of children fathered 0.2 0.3 1.3 0.4 -0.3 -1.1 0.0 0.5 0.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 2.2 0.7 0.9 0.9 0.2 0.2 0.5 1.5
Age at first live birth 1.0 1.8 6.8 0.6 -1.0 -0.9 -2.6 0.4 -1.7 -0.8
Pulse wave peak to peak time 1.4 1.6 5.0 0.8 1.3 2.2 0.5 -0.1 1.9 -0.4
Health satisfaction 1.4 1.8 10.6 -1.0 0.1 -0.2 3.3 0.5 -0.0 0.7
Shortness of breath walking on level ground 1.9 2.3 11.2 -1.6 0.4 -0.2 3.3 -0.6 1.1 0.6
Qualifications: College or University degree 1.4 4.5 9.8 -1.0 -3.1 -2.2 -2.9 -0.7 -2.6 -0.1
Eye problems/disorders: None of the above 0.5 0.6 1.5 -0.3 0.0 1.2 -0.8 -1.0 -1.0 -0.4
Mouth/teeth dental problems: Loose teeth 0.8 1.0 3.7 -1.3 -0.6 -0.4 1.9 -0.6 0.4 0.7
Emphysema/chronic bronchitis 2.4 2.7 7.4 -0.0 1.0 0.1 2.4 1.9 1.0 -2.7
Medication for pain relief, constipation, heartburn 1.2 2.0 7.8 0.8 2.0 2.8 -0.8 -0.5 0.7 0.6
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.4 -0.0 0.5 0.6 -0.6 0.6 -0.8
Medication: Blood pressure 7.4 13.1 34.1 -5.8 -3.9 -3.4 3.5 -3.0 -2.0 2.1
Angina (self-reported) 2.7 3.5 8.0 -2.2 -2.3 -2.8 2.4 -0.1 -0.4 -0.6
Migraine (self-reported) 1.0 1.3 2.4 1.0 -1.3 0.1 -1.6 0.9 -1.6 -0.8
Medication: Ibuprofen 0.4 0.5 1.8 1.3 -0.5 -0.3 -1.1 0.3 -0.2 -0.3
Medication: Allopurinol 1.0 1.3 2.8 -1.5 -0.6 -0.6 -0.2 -1.7 -1.2 1.3
Medication: Omeprazole 0.3 0.4 0.7 0.6 -0.5 -0.8 -0.7 0.6 -0.1 -0.5
Medication: Seretide 50 evohaler 1.1 1.3 4.8 -0.3 0.6 0.3 2.2 1.0 1.5 -0.6
Mean time to correctly identify matches 2.1 4.0 13.5 3.0 0.6 -0.3 -0.9 3.7 -0.0 -2.0
Heart disease (mother) 2.1 2.5 6.9 -2.6 -1.3 -1.9 0.9 -0.5 -1.9 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.4 2.8 6.9 -1.9 -2.5 -2.6 0.1 -0.9 -1.6 0.1
Whole body fat mass 1.6 6.5 20.6 -1.2 0.1 -3.6 4.5 2.2 2.2 -0.8
Leg fat mass (right) 1.2 4.8 13.5 -1.8 -0.5 -3.6 3.7 1.0 1.7 -0.6
Arm predicted mass (right) 2.8 14.3 31.6 2.4 5.6 4.3 4.1 3.0 4.3 -0.6
Pulse rate, automated reading 1.9 6.3 26.3 2.2 -0.1 -0.4 1.3 5.1 0.9 -3.2
Alcohol intake frequency. 1.0 2.2 5.5 0.5 -0.5 -2.1 1.7 1.6 2.3 0.0
Comparative height size at age 10 3.1 17.2 31.2 4.7 5.6 5.5 2.7 4.0 3.5 -0.6
Number of full sisters 0.8 0.9 3.1 -1.8 -0.5 -0.7 -0.3 -0.9 -1.1 0.7
Suffer from ‘nerves’ 3.3 5.2 17.2 1.3 2.3 4.2 2.5 1.2 1.1 -1.8
Overall health rating 0.8 1.8 8.7 -1.7 -0.0 -0.2 3.0 -0.4 0.3 0.9
Chest pain or discomfort 1.2 1.7 6.3 -0.3 0.8 1.4 2.5 0.7 1.6 -0.3
Had major operations 0.2 0.3 0.7 -0.6 -0.5 -0.8 0.1 0.3 -0.5 -0.4
Age at last live birth 1.1 1.6 6.2 1.3 -0.5 0.4 -2.5 0.0 -1.4 0.8
Family relationship satisfaction 0.6 0.7 1.9 0.4 1.2 0.8 1.4 1.0 0.0 0.1
Leg pain on walking 1.4 1.8 4.6 -2.1 -1.4 -0.9 1.5 -1.2 -0.9 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 5.2 2.3 1.1 0.6 0.1 1.4 0.9 0.0
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.5 0.8 -0.3 -0.3 0.1 0.7 0.2 -1.6
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 5.4 -0.1 -0.3 -1.0 -2.3 0.2 -0.8 -1.1
Medication: Aspirin 1.5 1.9 5.1 -1.6 -1.4 -2.3 1.3 0.1 -1.4 0.4
Supplements: Vitamin C 0.9 1.1 3.4 1.2 -1.1 -0.6 -1.8 0.1 -0.6 -0.8
Knee pain experienced in last month 3.0 4.6 10.1 2.8 1.7 1.5 1.7 3.2 1.3 -2.3
Hypertension (Self-reported) 9.5 26.3 63.5 -8.0 -5.2 -4.8 4.8 -5.2 -2.8 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.1 4.8 11.2 3.0 3.1 3.3 -1.2 0.9 1.3 0.1
Illnesses of father: Heart disease 0.5 0.7 2.5 -1.0 1.2 -0.1 1.6 0.4 0.4 -0.0
Illnesses of siblings: Diabetes 0.3 0.3 1.3 -0.1 -0.2 -0.9 -0.1 0.2 0.3 -1.1
Smoking status: Previous 0.6 0.8 2.3 1.5 0.9 0.5 -0.1 1.1 1.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 6.9 2.5 2.5 2.6 0.7 2.5 0.5 -1.0
Whole body fat-free mass 2.8 16.3 36.7 2.8 6.1 4.4 4.2 3.6 4.4 -0.7
Leg fat-free mass (right) 1.9 10.0 20.1 1.7 4.5 1.8 4.2 3.6 3.5 -0.5
Arm fat percentage (left) 2.4 9.6 42.2 -2.7 -2.4 -6.5 3.1 1.2 0.7 -0.6
Average weekly red wine intake 0.9 1.3 5.0 -0.2 -0.3 0.4 -2.2 -1.0 -1.7 0.0
Handedness (chirality/laterality): Left-handed 2.4 2.8 6.4 1.7 2.5 2.1 1.1 0.6 1.8 1.3
Mood swings 1.9 3.5 15.7 -1.8 0.0 1.2 4.0 -1.4 0.4 1.5
Loneliness, isolation 4.2 5.8 19.3 0.0 2.7 3.2 4.4 1.2 1.3 -0.8
Long-standing illness, disability or infirmity 0.7 1.1 3.7 -0.4 -0.9 -1.1 1.9 1.2 0.1 0.4
Ever had bowel cancer screening 1.2 1.4 3.7 1.9 1.2 0.7 -1.4 1.0 1.1 -0.0
Diabetes diagnosed by doctor 1.3 2.2 5.7 0.7 0.9 -0.5 2.2 2.4 1.5 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.9 1.1 0.7 0.7 -0.4 0.7 0.1 1.4
Friendships satisfaction 0.6 0.8 2.6 0.1 -0.7 -0.4 0.4 1.6 -1.3 0.2
Qualifications: nursing, teaching 1.3 2.0 3.9 -0.9 -1.8 -1.8 -1.6 -0.1 -2.0 -0.5
Commuting to job workplace: Walk 0.7 0.8 2.4 -0.5 0.7 1.0 1.6 0.1 1.0 0.4
Eye problems/disorders: Cataract 0.5 0.6 1.7 -0.1 -0.4 -0.8 -0.1 0.2 1.3 1.2
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.3 -1.1 -0.3 0.3 -0.8 -2.3 -0.1 1.4
Medication for cholesterol 3.1 4.6 11.6 3.4 2.5 3.0 -1.0 1.4 1.8 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.7 0.3 0.4 -0.6 1.3 0.5 0.0 -0.9
Back pain experienced in last month 0.7 1.0 2.8 -1.1 -0.5 0.2 -0.1 -1.4 -0.8 1.7
Mineral and other dietary supplements 2.0 2.7 8.1 0.2 0.2 0.7 2.9 2.4 1.0 -1.7
Breast cancer (self-reported) 0.3 0.4 1.9 0.1 0.4 0.5 0.1 -0.4 0.0 -1.4
Asthma (self-reported) 0.8 1.6 5.6 -2.4 -0.1 -0.7 1.6 -0.8 -0.9 -1.0
Osteoporosis (self-reported) 1.0 1.3 3.6 -0.5 1.2 1.5 -0.9 -1.9 0.3 0.7
Osteoarthritis (self-reported) 1.2 1.6 3.3 0.1 1.2 1.5 1.8 0.8 1.6 -0.8
Medication: Aspirin 1.1 1.5 4.0 -1.1 -0.9 -2.0 1.6 0.8 -0.9 0.2
Medication: Gliclazide 0.9 1.0 2.7 1.0 0.9 -0.1 0.7 0.9 1.7 1.1
Illnesses of father: None of the above (group 1) 1.7 2.1 5.3 2.3 0.9 2.0 -0.0 0.8 1.9 -0.1
Smoking status: Current 1.5 2.4 7.1 1.2 0.8 2.7 1.9 0.9 1.4 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 13.2 0.2 -0.8 0.2 -3.6 -1.8 -1.4 0.7
Whole body water mass 2.9 16.7 38.1 2.8 6.2 4.4 4.2 3.6 4.5 -0.6
Leg predicted mass (right) 1.9 10.2 20.0 1.7 4.5 1.8 4.3 3.7 3.6 -0.5
Arm fat mass (left) 1.5 6.1 16.4 -1.3 -0.0 -4.0 4.0 2.2 1.7 -0.6
Number of self-reported non-cancer illnesses 1.6 2.7 7.5 -2.7 -0.8 -1.4 2.7 -0.4 -1.1 -0.2
Average weekly champagne plus white wine intake 1.3 1.8 2.8 1.2 1.4 1.7 1.6 0.9 1.7 0.5
Miserableness 1.9 3.4 13.1 -1.7 0.7 1.6 3.6 -1.7 0.1 1.3
Guilty feelings 1.2 1.8 3.6 -1.9 -1.2 0.8 1.1 -1.7 -0.8 1.5
Wears glasses or contact lenses 2.3 2.7 6.2 -0.0 -1.4 -1.7 0.3 1.9 -1.9 -2.5
Ever taken oral contraceptive pill 0.9 1.0 3.4 1.2 1.2 1.8 -0.2 0.3 0.7 -0.4
Hearing aid user 1.1 1.2 2.5 -0.7 -1.2 -1.6 0.8 -0.8 0.7 1.5
Mother’s age at death 0.3 0.4 1.0 0.7 0.4 0.9 -1.0 -0.5 0.2 -0.0
Financial situation satisfaction 1.4 1.7 4.3 0.7 1.4 2.1 1.0 0.1 1.8 1.1
Tinnitus: Yes, now most or all of the time 2.9 3.4 8.9 1.6 1.4 2.1 -0.6 -0.6 2.2 3.0
Commuting to job workplace: Public transport 0.6 0.7 1.5 -1.2 -1.0 -0.5 -0.1 -0.1 -1.2 -0.7
Eye problems/disorders: Glaucoma 9.0 10.6 20.0 4.2 3.0 2.9 1.9 4.5 3.6 -1.7
Medication: Blood pressure 4.2 8.0 18.7 -4.3 -2.5 -3.2 2.2 -3.1 -2.0 1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.4 -0.9 -1.1 -1.2 0.4 0.1 -1.2 0.4
Supplements: Fish oil (including cod liver oil) 1.2 1.6 5.6 0.7 -0.4 -1.4 -2.4 -0.9 -1.3 0.6
High cholesterol (Self-reported) 1.0 1.8 4.5 -1.4 -0.6 -1.9 2.1 0.9 -0.9 -0.5
Medication: Bendroflumethiazide 4.5 6.8 18.0 -4.2 -2.0 -1.7 2.3 -3.1 -1.5 2.4
Medication: Paracetamol 0.4 0.6 2.7 -0.0 -1.0 -1.6 -0.2 0.5 -0.4 0.2
Medication: Lisinopril 3.7 4.8 16.4 -4.0 -1.6 -1.1 2.3 -2.6 -0.4 1.1
Medication: Atorvastatin 1.8 2.2 7.3 -0.3 0.0 -0.9 2.7 2.3 0.6 -1.2
Illnesses of father: High blood pressure 4.3 5.3 11.7 -3.4 -1.9 -2.0 1.7 -2.6 -1.9 2.2
Alcohol drinker status: Never 0.7 0.9 2.5 0.3 -1.3 -1.6 -0.9 0.5 0.0 -1.0
Ever smoked 0.3 0.5 1.3 1.1 -0.7 0.5 -0.8 0.6 -0.3 0.6
Basal metabolic rate 2.6 14.2 29.3 2.3 5.4 3.2 4.6 3.6 4.4 -0.8
Leg fat percentage (left) 1.9 7.0 26.0 -2.8 -2.4 -5.1 3.0 -0.1 0.7 -0.7
Arm fat-free mass (left) 2.8 14.0 30.8 2.1 5.5 4.1 4.4 2.8 4.3 -0.4
Number of operations (self-reported) 0.6 0.9 2.2 -0.2 -0.7 -1.5 -1.1 0.8 -0.4 -1.3
Average weekly beer plus cider intake 1.0 1.4 5.1 0.3 1.1 2.3 1.1 -0.5 1.4 -0.2
Irritability 1.8 3.1 10.6 0.7 1.6 1.7 3.3 0.7 2.1 -0.1
Risk taking 0.4 0.6 1.3 0.9 1.2 0.6 -0.9 0.4 -0.1 0.7
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.7 1.4 0.3 -0.0 -1.6 0.3 -0.5 1.6
Fractured/broken bones in last 5 years 0.8 1.0 3.1 -0.5 0.5 1.6 -0.9 -1.8 0.3 0.1
Age started oral contraceptive pill 1.4 1.7 3.5 1.4 1.9 1.7 -1.1 -0.5 1.5 0.3
Diastolic blood pressure, automated reading 5.2 16.0 37.8 -6.2 -5.0 -3.7 2.4 -3.6 -4.0 0.7
Ever depressed for a whole week 4.1 5.0 8.8 1.8 3.0 2.7 2.4 1.5 2.8 -0.7
Unable to work because of sickness or disability 1.1 1.4 3.9 -0.2 -0.5 -0.4 1.9 2.0 -0.1 -1.3
Commuting to job workplace: Cycle 2.2 2.7 4.8 -1.1 -1.9 -1.9 -2.2 -0.8 -2.2 0.4
Myopia 2.9 4.2 9.3 3.0 1.1 1.7 -0.4 3.1 -0.1 -2.6
Vascular/heart problems diagnosed by doctor 8.6 23.5 56.3 7.5 4.8 4.7 -4.7 4.7 2.7 -3.5
Cholesterol lowering medication 1.5 2.3 5.7 -1.1 -0.7 -2.1 2.4 1.2 -0.8 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.2 0.3 -0.7 -1.1 -0.6 0.4 -0.0 -0.6
Pain experienced in last month 0.3 0.6 1.5 -0.8 -0.2 -0.5 -1.2 -0.9 -0.8 0.2
Supplements: Calcium 0.6 0.6 1.7 0.2 0.1 -0.1 -0.9 0.5 -1.3 -1.3
Basal cell carcinoma (self-reported) 3.2 3.8 8.2 -1.8 -1.5 -1.6 -1.5 -2.9 -2.0 2.1
Heart attack/myocardial infarction (self-reported) 1.8 2.3 9.9 -0.4 1.0 -0.3 3.1 1.6 0.8 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.0 -0.1 1.4 0.7 1.3 0.7 1.1 -1.2
Heart disease (siblings) 0.8 1.0 3.6 0.6 -0.8 -0.2 0.7 1.9 0.6 -1.1
Alcohol drinker status: Previous 2.7 3.0 10.8 0.8 1.2 0.1 3.3 2.0 2.0 -0.4
Pack years of smoking 1.1 1.6 5.6 0.7 0.1 0.3 2.4 1.8 1.2 -0.1
Impedance of whole body 0.2 0.8 4.2 0.2 -2.1 -0.7 -0.4 0.2 -0.9 -0.4
Leg fat mass (left) 1.3 5.0 14.0 -1.7 -0.5 -3.7 3.7 1.1 1.5 -0.7
Arm predicted mass (left) 3.2 16.5 35.5 2.4 6.0 4.4 4.8 3.0 4.8 -0.4