TWAS hub - PTPRJ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0260	7.2e-07	0.045	0.048	0.036	0.046	0.051	3.5e-06	1.7e-06	3.2e-05	2.6e-06	7.6e-07
2	GTEx	Adipose Subcutaneous	0.0520	0.0320	5.6e-03	0.049	NA	0.023	NA	0.039	7.4e-05	NA	5.4e-03	NA	3.9e-04
3	GTEx	Nerve Tibial	0.0505	0.0274	3.9e-03	0.028	NA	0.031	NA	0.023	4.4e-03	NA	2.8e-03	NA	9.3e-03
4	GTEx	Spleen	0.2180	0.1060	7.0e-03	0.051	NA	-0.011	NA	0.025	1.9e-02	NA	8.0e-01	NA	7.5e-02
5	NTR	Blood	0.0352	0.0155	1.5e-06	0.011	0.022	0.011	0.022	0.013	1.1e-04	8.5e-08	1.3e-04	9.5e-08	3.9e-05
6	YFS	Blood	0.0167	0.0122	7.6e-04	0.012	0.013	0.016	0.016	0.014	6.2e-05	4.0e-05	3.4e-06	2.8e-06	1.7e-05
7	TCGA	Prostate Adenocarcinoma	0.0416	0.0223	6.7e-03	0.018	0.020	0.020	NA	0.026	5.4e-03	2.9e-03	3.3e-03	NA	9.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
HDL Cholesterol	13.0	21.7	47.5	6.9	4.1	5.3	0.1	5.7	4.3	-2.7
High blood pressure	10.0	28.0	67.4	-8.2	-5.3	-5.0	4.6	-5.4	-3.3	3.8
Systolic Blood Pressure	9.9	49.6	141.6	-11.9	-7.4	-4.8	6.4	-6.5	-6.5	1.4
Hypertension (Self-reported)	9.5	26.3	63.5	-8.0	-5.2	-4.8	4.8	-5.2	-2.8	3.4
Eye problems/disorders: Glaucoma	9.0	10.6	20.0	4.2	3.0	2.9	1.9	4.5	3.6	-1.7
Vascular/heart problems diagnosed by doctor	8.6	23.5	56.3	7.5	4.8	4.7	-4.7	4.7	2.7	-3.5
Medication: Blood pressure	7.4	13.1	34.1	-5.8	-3.9	-3.4	3.5	-3.0	-2.0	2.1
Blood White Count	6.6	49.3	75.0	-6.6	-8.6	-8.7	-6.3	-7.4	-7.1	2.8
Systolic blood pressure, automated reading	6.4	18.6	50.0	-7.1	-4.9	-3.8	2.8	-3.8	-4.4	0.7
Cardiovascular Disease	6.3	20.8	53.9	-7.3	-3.7	-4.6	6.7	-2.5	-2.0	1.3
Diastolic blood pressure, automated reading	5.2	16.0	37.8	-6.2	-5.0	-3.7	2.4	-3.6	-4.0	0.7
High blood pressure (siblings)	5.0	7.3	16.3	-4.0	-2.3	-2.5	1.3	-3.6	-1.5	2.4
Fasting Glucose	4.9	5.9	11.7	3.0	2.2	1.8	0.5	3.4	2.5	-2.4
Standing height	4.9	48.3	96.8	6.5	9.5	9.8	5.3	6.2	6.4	-0.9
Glaucoma (self-reported)	4.7	5.6	10.2	3.2	2.4	2.1	1.5	3.0	2.5	-1.0
Medication: Bendroflumethiazide	4.5	6.8	18.0	-4.2	-2.0	-1.7	2.3	-3.1	-1.5	2.4
Illnesses of father: High blood pressure	4.3	5.3	11.7	-3.4	-1.9	-2.0	1.7	-2.6	-1.9	2.2
Loneliness, isolation	4.2	5.8	19.3	0.0	2.7	3.2	4.4	1.2	1.3	-0.8
Medication: Blood pressure	4.2	8.0	18.7	-4.3	-2.5	-3.2	2.2	-3.1	-2.0	1.4
Medication: Metformin	4.1	5.8	14.7	1.4	3.1	1.0	3.2	1.7	3.8	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.1	4.8	11.2	3.0	3.1	3.3	-1.2	0.9	1.3	0.1
Ever depressed for a whole week	4.1	5.0	8.8	1.8	3.0	2.7	2.4	1.5	2.8	-0.7
Comparative body size at age 10	4.0	11.0	41.7	-3.6	-3.7	-6.5	2.6	0.6	-1.0	0.7
Height	3.9	75.9	148.8	8.3	11.7	12.2	6.5	8.4	7.8	-2.1
Medication: Amlodipine	3.9	5.5	11.9	-3.5	-2.3	-2.1	3.1	-1.8	-1.8	0.8
Medication: Lisinopril	3.7	4.8	16.4	-4.0	-1.6	-1.1	2.3	-2.6	-0.4	1.1
Major Depression (MDD)	3.6	4.3	11.8	0.3	0.9	3.1	3.4	-0.2	2.8	0.2
Trunk fat-free mass	3.6	20.5	45.8	3.5	6.8	5.9	3.9	3.7	4.5	-0.9
Hearing difficulty/problems with background noise	3.5	5.7	16.5	-1.9	-0.3	0.8	-2.0	-4.1	-0.7	3.7
Trunk predicted mass	3.5	20.1	45.2	3.5	6.7	5.9	3.9	3.6	4.5	-0.8
Waist Hip Ratio (WHR)	3.4	15.3	34.7	5.0	4.4	2.1	2.0	5.9	3.4	-2.9
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.6	15.4	-0.0	3.1	3.0	3.9	0.5	2.1	0.6
Lung cancer (father)	3.4	4.0	9.3	2.1	2.3	3.0	1.0	1.2	2.4	0.6
Suffer from ‘nerves’	3.3	5.2	17.2	1.3	2.3	4.2	2.5	1.2	1.1	-1.8
Basal cell carcinoma (self-reported)	3.2	3.8	8.2	-1.8	-1.5	-1.6	-1.5	-2.9	-2.0	2.1
Arm predicted mass (left)	3.2	16.5	35.5	2.4	6.0	4.4	4.8	3.0	4.8	-0.4
Comparative height size at age 10	3.1	17.2	31.2	4.7	5.6	5.5	2.7	4.0	3.5	-0.6
Medication for cholesterol	3.1	4.6	11.6	3.4	2.5	3.0	-1.0	1.4	1.8	0.0
Fluid intelligence score	3.0	6.2	15.6	1.9	2.6	3.9	1.6	1.9	2.8	-1.8
Knee pain experienced in last month	3.0	4.6	10.1	2.8	1.7	1.5	1.7	3.2	1.3	-2.3
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	7.7	0.7	2.0	2.0	2.8	1.4	2.6	0.2
Whole body water mass	2.9	16.7	38.1	2.8	6.2	4.4	4.2	3.6	4.5	-0.6
Tinnitus: Yes, now most or all of the time	2.9	3.4	8.9	1.6	1.4	2.1	-0.6	-0.6	2.2	3.0
Myopia	2.9	4.2	9.3	3.0	1.1	1.7	-0.4	3.1	-0.1	-2.6
Severe depression (siblings)	2.8	3.1	8.2	2.0	2.5	2.9	0.1	0.9	1.6	-0.8
Arm predicted mass (right)	2.8	14.3	31.6	2.4	5.6	4.3	4.1	3.0	4.3	-0.6
Whole body fat-free mass	2.8	16.3	36.7	2.8	6.1	4.4	4.2	3.6	4.4	-0.7
Arm fat-free mass (left)	2.8	14.0	30.8	2.1	5.5	4.1	4.4	2.8	4.3	-0.4
Angina (self-reported)	2.7	3.5	8.0	-2.2	-2.3	-2.8	2.4	-0.1	-0.4	-0.6
Alcohol drinker status: Previous	2.7	3.0	10.8	0.8	1.2	0.1	3.3	2.0	2.0	-0.4
Depressed Affect (Nagel 2018)	2.6	5.5	24.1	-1.8	1.1	2.1	4.9	-1.4	0.8	1.6
Medication: Ramipril	2.6	3.3	9.3	-2.6	-1.2	-1.7	3.0	-0.4	-1.6	-0.6
Medication for cholesterol, blood pressure or diabetes	2.6	4.2	11.1	3.3	2.2	2.0	-2.7	1.0	0.5	-1.1
Basal metabolic rate	2.6	14.2	29.3	2.3	5.4	3.2	4.6	3.6	4.4	-0.8
Angina	2.5	3.3	7.4	-2.1	-2.2	-2.7	2.4	-0.1	-0.3	-0.5
Age when periods started (menarche)	2.5	5.9	18.8	3.1	3.0	4.3	-1.6	0.6	0.8	0.7
Arm fat-free mass (right)	2.5	13.0	28.3	2.1	5.3	4.2	4.0	2.8	4.1	-0.7
Alzheimer’s Disease (in father)	2.4	2.6	7.8	1.2	2.5	2.8	0.0	-0.4	1.4	0.3
Verbal and Numeric Reasoning (VNR)	2.4	5.8	15.9	2.0	2.5	4.0	0.3	2.2	2.1	-2.3
Coronary Artery Disease (CAD)	2.4	2.9	7.2	-0.7	-1.9	-2.7	1.4	1.4	-1.9	-1.3
Number of treatments/medications taken	2.4	4.4	12.5	-2.0	-1.4	-3.0	3.5	1.1	-0.8	-1.0
Emphysema/chronic bronchitis	2.4	2.7	7.4	-0.0	1.0	0.1	2.4	1.9	1.0	-2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	6.9	-1.9	-2.5	-2.6	0.1	-0.9	-1.6	0.1
Arm fat percentage (left)	2.4	9.6	42.2	-2.7	-2.4	-6.5	3.1	1.2	0.7	-0.6
Handedness (chirality/laterality): Left-handed	2.4	2.8	6.4	1.7	2.5	2.1	1.1	0.6	1.8	1.3
Ever used hormone-replacement therapy (HRT)	2.3	2.9	6.1	-1.1	-1.4	-2.5	-2.2	-1.1	-2.2	0.5
Illnesses of siblings	2.3	3.2	8.9	3.0	2.1	2.1	-1.2	1.7	0.6	-0.2
Neuroticism score	2.3	4.7	16.5	-0.5	1.7	3.2	4.1	-0.6	1.2	1.0
Wears glasses or contact lenses	2.3	2.7	6.2	-0.0	-1.4	-1.7	0.3	1.9	-1.9	-2.5
Chronotype (morning person)	2.2	5.1	17.3	-2.9	-0.5	-2.4	4.2	-0.5	1.5	1.3
Townsend deprivation index at recruitment	2.2	3.1	7.2	0.8	1.3	2.0	2.7	1.5	1.7	-1.7
High blood pressure (mother)	2.2	3.1	10.1	-2.7	-0.8	-1.4	3.2	-0.8	-0.6	1.0
Forced vital capacity (FVC)	2.2	8.3	29.7	2.6	3.6	5.5	0.3	1.1	2.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	15.4	3.3	-0.2	-1.2	-1.5	3.9	-0.9	-2.0
Depression (self-reported)	2.2	2.6	7.2	-0.2	0.5	0.7	2.6	1.9	0.7	-2.7
Commuting to job workplace: Cycle	2.2	2.7	4.8	-1.1	-1.9	-1.9	-2.2	-0.8	-2.2	0.4
Mean Putamen Volume	2.1	2.4	5.7	-1.3	-1.7	-2.4	2.3	0.9	-0.5	-0.7
Arm fat percentage (right)	2.1	8.3	37.0	-2.3	-2.1	-6.1	3.0	1.2	0.7	-0.6
Body fat percentage	2.1	8.1	30.0	-2.2	-1.8	-5.5	3.8	1.4	1.4	-0.8
Mean time to correctly identify matches	2.1	4.0	13.5	3.0	0.6	-0.3	-0.9	3.7	-0.0	-2.0
Heart disease (mother)	2.1	2.5	6.9	-2.6	-1.3	-1.9	0.9	-0.5	-1.9	-0.8
Trunk fat percentage	2.0	7.9	26.9	-1.4	-1.3	-5.2	3.9	2.4	1.6	-1.1
Fed-up feelings	2.0	3.6	11.4	-2.0	0.0	0.1	3.4	-1.9	0.4	2.5
Hair/balding pattern: Pattern 4	2.0	4.8	14.0	-1.6	-2.8	-3.7	-0.7	0.3	-2.4	-1.6
Mineral and other dietary supplements	2.0	2.7	8.1	0.2	0.2	0.7	2.9	2.4	1.0	-1.7
Intelligence (Savage-Jansen 2018)	1.9	5.8	14.1	1.8	1.9	3.8	0.5	2.4	1.8	-3.2
Neuroticism (Nagel 2018)	1.9	4.6	17.3	-1.4	1.5	2.7	4.2	-1.4	0.8	0.4
Body Mass Index (BMI) (2010)	1.9	2.5	5.6	-0.2	0.7	-1.9	2.4	1.3	2.2	-1.1
Type 2 Diabetes (T2D) (2018)	1.9	3.5	9.3	0.9	1.2	-0.2	3.1	2.2	2.3	-1.6
Leg fat-free mass (left)	1.9	10.0	20.4	1.6	4.5	1.8	4.1	3.5	3.7	-0.5
Stomach or abdominal pain in last month	1.9	2.4	6.3	0.1	1.9	1.7	2.5	-0.4	1.7	1.0
Birth weight of first child	1.9	3.5	6.9	2.6	2.3	2.0	-0.6	1.1	1.7	2.1
Shortness of breath walking on level ground	1.9	2.3	11.2	-1.6	0.4	-0.2	3.3	-0.6	1.1	0.6
Pulse rate, automated reading	1.9	6.3	26.3	2.2	-0.1	-0.4	1.3	5.1	0.9	-3.2
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	6.9	2.5	2.5	2.6	0.7	2.5	0.5	-1.0
Leg fat-free mass (right)	1.9	10.0	20.1	1.7	4.5	1.8	4.2	3.6	3.5	-0.5
Mood swings	1.9	3.5	15.7	-1.8	0.0	1.2	4.0	-1.4	0.4	1.5
Leg predicted mass (right)	1.9	10.2	20.0	1.7	4.5	1.8	4.3	3.7	3.6	-0.5
Miserableness	1.9	3.4	13.1	-1.7	0.7	1.6	3.6	-1.7	0.1	1.3
Leg fat percentage (left)	1.9	7.0	26.0	-2.8	-2.4	-5.1	3.0	-0.1	0.7	-0.7
Bipolar Disorder (2011)	1.8	1.8	5.1	1.3	0.5	0.6	1.7	2.2	0.6	-1.4
Neuroticism (2016)	1.8	2.6	6.2	-1.0	1.5	2.5	2.1	-1.9	0.1	0.9
Ulcerative Colitis	1.8	2.6	9.4	-0.7	-3.1	-2.0	-1.3	-0.2	-1.5	-0.1
Heel T-Score	1.8	14.7	34.7	4.8	-3.4	-2.8	-5.9	4.4	-2.3	-1.0
Smoking Status	1.8	4.2	12.2	2.7	0.3	1.4	1.8	3.5	0.5	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	11.5	2.7	-0.7	-1.1	-1.6	3.4	-0.8	-2.2
Sitting height	1.8	12.9	33.5	1.2	4.6	5.8	5.0	1.7	2.6	-0.3
Leg predicted mass (left)	1.8	9.7	20.0	1.6	4.5	1.7	4.1	3.5	3.7	-0.6
Waist circumference	1.8	6.4	14.9	0.6	1.7	-2.2	3.9	3.3	2.8	-1.8
Weight	1.8	9.1	25.3	0.9	3.2	0.1	5.0	3.4	3.8	-0.9
Number of live births	1.8	2.6	4.1	-1.8	-1.5	-1.1	-1.7	-2.0	-1.7	0.9
Medication: Atorvastatin	1.8	2.2	7.3	-0.3	0.0	-0.9	2.7	2.3	0.6	-1.2
Irritability	1.8	3.1	10.6	0.7	1.6	1.7	3.3	0.7	2.1	-0.1
Heart attack/myocardial infarction (self-reported)	1.8	2.3	9.9	-0.4	1.0	-0.3	3.1	1.6	0.8	-1.2
Neuroticism	1.7	4.1	16.2	-1.0	1.7	2.8	4.0	-0.3	0.3	-0.3
Hand grip strength (left)	1.7	4.5	13.2	0.2	1.8	3.6	-1.5	-1.9	-1.2	2.8
Qualifications: CSEs or equivalent	1.7	2.2	4.8	-0.6	1.5	1.7	2.2	-0.5	2.2	0.1
Trunk fat mass	1.7	7.5	22.7	-0.6	0.4	-3.5	4.8	3.0	2.6	-1.2
Number of incorrect matches in round	1.7	2.8	7.4	2.7	0.9	0.1	-2.6	0.0	0.7	2.0
Heart attack	1.7	2.2	9.9	-0.4	0.8	-0.6	3.1	1.6	0.6	-1.2
Illnesses of mother	1.7	2.1	9.6	1.9	0.5	0.5	-3.1	0.2	-0.2	-0.9
Forced vital capacity (FVC), Best measure	1.7	6.3	26.5	2.6	2.7	5.2	-0.5	1.3	1.4	0.2
Leg fat percentage (right)	1.7	6.1	22.5	-2.7	-2.2	-4.7	2.7	-0.2	0.9	-0.7
Illnesses of father: None of the above (group 1)	1.7	2.1	5.3	2.3	0.9	2.0	-0.0	0.8	1.9	-0.1
Reaction Time	1.6	3.1	12.3	2.4	0.2	-0.8	-0.5	3.5	-0.1	-1.7
Type 2 Diabetes (T2D) (2012)	1.6	1.9	9.9	-0.6	0.7	-0.7	3.1	0.7	1.2	-0.2
Medication: Levothyroxine sodium	1.6	2.8	5.6	-2.1	-1.8	-2.4	-0.5	-1.6	-1.5	1.1
Falls in the last year	1.6	2.1	6.1	-2.5	-1.1	-0.8	2.4	-0.4	-0.6	-0.8
Pulse wave reflection index	1.6	2.0	5.7	-0.7	-0.6	-0.9	-1.6	-1.8	-0.8	2.4
Whole body fat mass	1.6	6.5	20.6	-1.2	0.1	-3.6	4.5	2.2	2.2	-0.8
Number of self-reported non-cancer illnesses	1.6	2.7	7.5	-2.7	-0.8	-1.4	2.7	-0.4	-1.1	-0.2
Worry (Nagel 2018)	1.5	3.2	11.2	0.1	1.4	2.8	3.3	0.1	0.7	-0.9
Irritable Bowel Disease (IBD)	1.5	3.5	10.8	-1.8	-3.3	-2.0	0.2	-1.4	-1.0	1.7
Blood Eosinophil Count	1.5	11.3	23.6	-3.8	-3.7	-3.6	-1.0	-4.9	-3.4	1.3
Medication for hormone replacement therapy	1.5	1.7	4.9	-0.8	-1.9	-1.0	-2.2	-0.1	-1.2	-0.4
Average weekly fortified wine intake	1.5	1.8	9.4	1.1	0.3	0.5	-3.1	-0.6	-1.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.4	0.6	1.4	2.2	2.3	1.2	1.1	-1.0
Birth weight	1.5	3.2	7.2	2.1	2.2	2.7	1.2	2.0	0.6	0.2
Medication: Aspirin	1.5	1.9	5.1	-1.6	-1.4	-2.3	1.3	0.1	-1.4	0.4
Smoking status: Current	1.5	2.4	7.1	1.2	0.8	2.7	1.9	0.9	1.4	1.1
Arm fat mass (left)	1.5	6.1	16.4	-1.3	-0.0	-4.0	4.0	2.2	1.7	-0.6
Cholesterol lowering medication	1.5	2.3	5.7	-1.1	-0.7	-2.1	2.4	1.2	-0.8	-1.4
Depression (Nagel 2018)	1.4	2.1	4.9	0.6	0.8	2.2	2.2	0.9	1.7	0.5
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.8	-0.0	0.5	2.0	2.2	-0.4	1.2	1.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.1	-1.4	-1.5	-1.3	0.2	-0.9	-2.0	0.3
Nervous feelings	1.4	2.5	11.4	-0.7	1.2	1.9	3.4	-0.1	0.4	-0.7
Worrier / anxious feelings	1.4	2.7	6.4	1.2	2.0	2.5	2.0	0.7	1.2	-1.1
Mouth/teeth dental problems: Dentures	1.4	2.3	5.2	2.1	1.4	1.8	-0.2	1.1	2.3	0.6
Arm fat mass (right)	1.4	5.6	15.5	-1.5	0.0	-3.8	3.9	1.8	1.9	-0.5
Exposure to tobacco smoke outside home	1.4	1.8	9.5	-1.0	0.6	0.1	3.1	-0.4	1.3	0.0
Pulse wave peak to peak time	1.4	1.6	5.0	0.8	1.3	2.2	0.5	-0.1	1.9	-0.4
Health satisfaction	1.4	1.8	10.6	-1.0	0.1	-0.2	3.3	0.5	-0.0	0.7
Qualifications: College or University degree	1.4	4.5	9.8	-1.0	-3.1	-2.2	-2.9	-0.7	-2.6	-0.1
Leg pain on walking	1.4	1.8	4.6	-2.1	-1.4	-0.9	1.5	-1.2	-0.9	0.7
Financial situation satisfaction	1.4	1.7	4.3	0.7	1.4	2.1	1.0	0.1	1.8	1.1
Age started oral contraceptive pill	1.4	1.7	3.5	1.4	1.9	1.7	-1.1	-0.5	1.5	0.3
Bipolar Disorder (2018)	1.3	2.0	5.1	0.7	-0.0	-0.2	1.6	2.0	-1.4	-2.3
Hearing difficulty/problems: Yes	1.3	2.0	4.9	-0.3	0.5	0.8	-1.9	-2.1	0.5	2.2
Taking other prescription medications	1.3	2.0	6.5	-0.8	-0.3	-1.8	2.5	1.3	0.3	-1.4
Body mass index (BMI)	1.3	5.4	22.2	-2.3	-1.1	-4.7	2.8	0.5	0.9	-0.4
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	4.8	-1.1	-0.5	-1.2	2.2	-0.9	0.2	1.6
Diabetes diagnosed by doctor	1.3	2.2	5.7	0.7	0.9	-0.5	2.2	2.4	1.5	-1.2
Qualifications: nursing, teaching	1.3	2.0	3.9	-0.9	-1.8	-1.8	-1.6	-0.1	-2.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	13.2	0.2	-0.8	0.2	-3.6	-1.8	-1.4	0.7
Average weekly champagne plus white wine intake	1.3	1.8	2.8	1.2	1.4	1.7	1.6	0.9	1.7	0.5
Leg fat mass (left)	1.3	5.0	14.0	-1.7	-0.5	-3.7	3.7	1.1	1.5	-0.7
Crohns Disease (2012)	1.2	1.9	6.2	-1.4	-2.5	-1.9	0.0	-0.8	-0.9	-0.1
BMI	1.2	7.1	24.0	-2.6	-0.7	-4.9	3.7	0.4	1.9	-0.9
Supplements: Zinc	1.2	1.3	4.0	0.9	0.3	0.8	-2.0	-0.1	-1.5	-1.1
Current tobacco smoking	1.2	2.0	6.4	1.1	0.7	2.5	1.8	0.8	1.1	1.1
Breastfed as a baby	1.2	1.4	3.9	1.2	0.5	1.2	-0.0	2.0	0.1	-1.8
Blood clot in the leg (DVT)	1.2	1.5	3.1	0.3	1.8	1.2	1.1	0.8	1.4	-1.4
Medication for pain relief, constipation, heartburn	1.2	2.0	7.8	0.8	2.0	2.8	-0.8	-0.5	0.7	0.6
Leg fat mass (right)	1.2	4.8	13.5	-1.8	-0.5	-3.6	3.7	1.0	1.7	-0.6
Chest pain or discomfort	1.2	1.7	6.3	-0.3	0.8	1.4	2.5	0.7	1.6	-0.3
Ever had bowel cancer screening	1.2	1.4	3.7	1.9	1.2	0.7	-1.4	1.0	1.1	-0.0
Osteoarthritis (self-reported)	1.2	1.6	3.3	0.1	1.2	1.5	1.8	0.8	1.6	-0.8
Guilty feelings	1.2	1.8	3.6	-1.9	-1.2	0.8	1.1	-1.7	-0.8	1.5
Supplements: Fish oil (including cod liver oil)	1.2	1.6	5.6	0.7	-0.4	-1.4	-2.4	-0.9	-1.3	0.6
Crohns Disease (2017)	1.1	2.4	6.1	-1.6	-2.5	-1.8	0.8	-1.4	-0.5	1.5
Ovarian Cancer	1.1	1.5	3.9	0.9	1.4	1.2	-2.0	-0.6	0.3	1.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.1	-1.2	-0.7	-2.0	1.2	0.5	-0.2	-0.6
Diabetes (mother)	1.1	1.4	3.0	0.6	1.2	0.9	1.7	1.5	1.2	-0.8
Mouth/teeth dental problems	1.1	1.7	5.2	-0.4	-0.5	-0.9	-1.5	0.5	-2.3	-1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	15.5	1.4	2.5	3.9	-0.2	0.5	1.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	14.8	1.9	1.9	3.9	-1.2	0.9	0.5	-0.3
Medication: Seretide 50 evohaler	1.1	1.3	4.8	-0.3	0.6	0.3	2.2	1.0	1.5	-0.6
Age at last live birth	1.1	1.6	6.2	1.3	-0.5	0.4	-2.5	0.0	-1.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	5.2	2.3	1.1	0.6	0.1	1.4	0.9	0.0
Medication: Aspirin	1.1	1.5	4.0	-1.1	-0.9	-2.0	1.6	0.8	-0.9	0.2
Hearing aid user	1.1	1.2	2.5	-0.7	-1.2	-1.6	0.8	-0.8	0.7	1.5
Unable to work because of sickness or disability	1.1	1.4	3.9	-0.2	-0.5	-0.4	1.9	2.0	-0.1	-1.3
Pack years of smoking	1.1	1.6	5.6	0.7	0.1	0.3	2.4	1.8	1.2	-0.1
Alzheimer’s Disease (including proxy)	1.0	1.4	5.4	0.9	1.3	2.3	1.3	-0.0	0.5	-0.3
Ulcerative Colitis (UC)	1.0	1.8	5.6	-1.2	-2.4	-1.3	-0.3	-0.9	-0.9	1.5
Rheumatoid Arthritis	1.0	1.4	5.5	1.2	-0.0	-0.5	-2.3	-0.7	0.1	1.4
Hand grip strength (right)	1.0	2.6	9.1	-0.4	1.4	3.0	-0.2	-1.9	-0.3	1.8
Supplements: Glucosamine	1.0	1.4	7.7	0.7	0.4	0.5	-2.8	-0.9	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.5	1.2	0.6	-0.1	0.9	1.9	0.9	-1.2
Medication: Atenolol	1.0	1.2	4.9	-0.5	-0.5	-0.4	-0.0	-1.6	-0.5	2.2
Diabetes (self-reported)	1.0	1.6	3.8	0.2	0.2	-1.0	1.8	2.0	1.3	-1.2
Medication: Simvastatin	1.0	1.4	3.8	-1.0	-0.9	-2.0	0.4	0.8	-1.9	-0.1
Loud music exposure frequency	1.0	1.1	2.1	-1.1	-0.4	-1.4	1.0	-1.3	0.7	1.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.3	-2.0	-1.4	-2.3	0.2	-1.0	-1.3	0.3
Number of full brothers	1.0	1.2	2.5	-1.2	-1.6	-0.8	-1.2	-0.8	-1.3	-0.2
Age at first live birth	1.0	1.8	6.8	0.6	-1.0	-0.9	-2.6	0.4	-1.7	-0.8
Migraine (self-reported)	1.0	1.3	2.4	1.0	-1.3	0.1	-1.6	0.9	-1.6	-0.8
Medication: Allopurinol	1.0	1.3	2.8	-1.5	-0.6	-0.6	-0.2	-1.7	-1.2	1.3
Alcohol intake frequency.	1.0	2.2	5.5	0.5	-0.5	-2.1	1.7	1.6	2.3	0.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	5.4	-0.1	-0.3	-1.0	-2.3	0.2	-0.8	-1.1
Osteoporosis (self-reported)	1.0	1.3	3.6	-0.5	1.2	1.5	-0.9	-1.9	0.3	0.7
High cholesterol (Self-reported)	1.0	1.8	4.5	-1.4	-0.6	-1.9	2.1	0.9	-0.9	-0.5
Average weekly beer plus cider intake	1.0	1.4	5.1	0.3	1.1	2.3	1.1	-0.5	1.4	-0.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.7	1.4	0.3	-0.0	-1.6	0.3	-0.5	1.6
Bipolar Disorder or Schizophrenia	0.9	2.2	8.0	0.2	0.1	-0.3	2.8	2.4	-0.1	-1.2
Pack years adult smoking proportion	0.9	1.3	5.7	0.4	-0.1	0.1	2.4	1.5	1.0	0.2
Financial difficulties in last 2 years	0.9	1.2	2.4	-1.1	0.6	1.5	0.4	-1.4	0.1	1.6
Pulse rate	0.9	1.5	4.0	0.1	0.5	-0.4	1.4	2.0	0.0	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.3	-0.3	0.5	-0.3	1.8	-0.1	0.3	1.7
Asthma	0.9	1.7	5.9	-2.4	-0.4	-1.0	1.4	-0.8	-1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	0.5	-1.4	-1.1	-1.5	0.3	-1.1	-0.9
Length of working week for main job	0.9	1.0	2.3	-0.9	-1.5	0.2	-1.4	-1.3	-0.0	0.3
Tense / ‘highly strung’	0.9	1.6	6.7	-1.7	-0.5	-0.1	2.6	-1.0	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.3	0.3	0.5	0.7	1.8	1.2	1.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.8	0.6	0.1	0.8	1.7	1.7	-0.1	-1.3
Wheeze or whistling in the chest in last year	0.9	1.7	7.5	-1.3	0.9	0.2	2.7	-0.6	1.1	0.6
Supplements: Vitamin C	0.9	1.1	3.4	1.2	-1.1	-0.6	-1.8	0.1	-0.6	-0.8
Average weekly red wine intake	0.9	1.3	5.0	-0.2	-0.3	0.4	-2.2	-1.0	-1.7	0.0
Medication: Gliclazide	0.9	1.0	2.7	1.0	0.9	-0.1	0.7	0.9	1.7	1.1
Ever taken oral contraceptive pill	0.9	1.0	3.4	1.2	1.2	1.8	-0.2	0.3	0.7	-0.4
Breast Cancer	0.8	1.9	8.5	-1.5	-1.1	-0.4	2.9	-0.9	0.6	0.2
Age at First Birth	0.8	1.2	3.3	-0.4	-1.8	-1.7	-0.3	0.3	-1.1	-0.7
Lupus	0.8	1.2	2.3	1.1	1.4	1.5	-0.9	0.8	1.2	0.4
Maternal smoking around birth	0.8	1.1	3.5	-1.9	-0.3	-1.0	1.6	-0.7	0.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.3	-1.4	-0.6	-0.1	-0.0	-1.5	0.7	1.0
Allergy	0.8	1.8	6.6	1.4	-0.5	0.5	-2.6	-0.3	0.1	1.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.0	-0.7	0.2	-0.3	0.7	-1.4	1.2	1.7
Hip circumference	0.8	3.6	13.8	-1.6	0.5	-2.1	3.7	0.6	1.8	-0.6
Noisy workplace	0.8	1.0	4.2	-0.7	0.3	-1.0	2.0	-0.2	-0.5	0.8
Prospective memory result	0.8	1.0	3.1	-1.8	-0.3	-0.7	0.8	-1.3	-0.2	0.9
Exposure to tobacco smoke at home	0.8	0.9	2.0	-0.3	1.0	0.1	0.9	-1.4	0.6	1.3
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.7	-1.3	-0.6	-0.4	1.9	-0.6	0.4	0.7
Number of full sisters	0.8	0.9	3.1	-1.8	-0.5	-0.7	-0.3	-0.9	-1.1	0.7
Overall health rating	0.8	1.8	8.7	-1.7	-0.0	-0.2	3.0	-0.4	0.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.3	-1.1	-0.3	0.3	-0.8	-2.3	-0.1	1.4
Asthma (self-reported)	0.8	1.6	5.6	-2.4	-0.1	-0.7	1.6	-0.8	-0.9	-1.0
Fractured/broken bones in last 5 years	0.8	1.0	3.1	-0.5	0.5	1.6	-0.9	-1.8	0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.0	-0.1	1.4	0.7	1.3	0.7	1.1	-1.2
Heart disease (siblings)	0.8	1.0	3.6	0.6	-0.8	-0.2	0.7	1.9	0.6	-1.1
Hypothyroidism (self reported)	0.7	1.7	4.6	-1.2	-1.2	-2.2	-0.3	-0.7	-0.5	1.8
Respiratory disease	0.7	1.6	4.8	-1.8	0.8	0.2	2.2	-0.2	0.5	-1.5
Average weekly spirits intake	0.7	0.9	3.0	-0.7	-0.7	-0.8	-0.7	-0.7	-0.7	1.7
Hair/balding pattern: Pattern 3	0.7	1.1	2.4	-1.4	0.5	-0.5	0.8	-1.6	0.6	1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	4.0	1.1	0.4	0.3	0.7	2.0	1.0	-0.7
Medication: Paracetamol	0.7	1.2	4.6	-0.8	-1.6	-2.2	0.4	0.4	-0.3	-0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.9	0.3	1.1	1.1	1.1	-0.7	1.4	0.5
Long-standing illness, disability or infirmity	0.7	1.1	3.7	-0.4	-0.9	-1.1	1.9	1.2	0.1	0.4
Commuting to job workplace: Walk	0.7	0.8	2.4	-0.5	0.7	1.0	1.6	0.1	1.0	0.4
Back pain experienced in last month	0.7	1.0	2.8	-1.1	-0.5	0.2	-0.1	-1.4	-0.8	1.7
Alcohol drinker status: Never	0.7	0.9	2.5	0.3	-1.3	-1.6	-0.9	0.5	0.0	-1.0
Schizophrenia (2018)	0.6	1.3	5.5	-0.3	0.1	-0.2	2.3	1.5	1.0	0.2
Schizophrenia (2014)	0.6	1.4	5.8	-0.2	0.2	0.2	2.4	1.6	0.7	-1.0
Triglycerides	0.6	1.0	2.1	-0.7	1.0	0.3	1.4	-1.1	0.9	1.3
Relative age of first facial hair	0.6	1.2	2.4	1.3	1.3	1.5	0.4	0.8	1.2	0.1
Medication: Co-codamol	0.6	0.7	1.5	0.8	0.8	0.4	1.0	-0.1	1.2	0.9
Diabetes (father)	0.6	0.7	2.2	-1.2	-0.1	-1.5	0.8	-0.2	-0.2	-0.8
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-0.9	-1.0	-1.0	1.1	-0.8	0.4	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.6	0.0	-0.1	-0.9	0.4	1.6	-0.7	-0.9
Hair/balding pattern: Pattern 2	0.6	0.7	3.2	0.6	-0.1	1.8	-0.5	0.2	0.0	-1.1
Father’s age at death	0.6	0.9	2.9	1.2	0.7	0.4	-1.7	-0.1	-0.8	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.4	1.7	0.4	0.6	-2.1	0.9	-0.0	0.6
Medication: Cholesterol lowering	0.6	0.9	3.4	-0.6	0.2	-0.9	1.8	1.3	0.4	-0.3
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-0.4	-0.4	-1.4	0.1	0.5	-1.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.2	0.7	0.9	0.9	0.2	0.2	0.5	1.5
Family relationship satisfaction	0.6	0.7	1.9	0.4	1.2	0.8	1.4	1.0	0.0	0.1
Smoking status: Previous	0.6	0.8	2.3	1.5	0.9	0.5	-0.1	1.1	1.1	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.9	1.1	0.7	0.7	-0.4	0.7	0.1	1.4
Friendships satisfaction	0.6	0.8	2.6	0.1	-0.7	-0.4	0.4	1.6	-1.3	0.2
Commuting to job workplace: Public transport	0.6	0.7	1.5	-1.2	-1.0	-0.5	-0.1	-0.1	-1.2	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	-0.9	-1.1	-1.2	0.4	0.1	-1.2	0.4
Number of operations (self-reported)	0.6	0.9	2.2	-0.2	-0.7	-1.5	-1.1	0.8	-0.4	-1.3
Supplements: Calcium	0.6	0.6	1.7	0.2	0.1	-0.1	-0.9	0.5	-1.3	-1.3
HbA1C	0.5	0.5	1.2	-0.3	-0.9	-0.1	-1.0	-0.7	-1.1	-0.4
Blood Platelet Count	0.5	6.3	19.4	-0.9	-1.3	2.9	-4.4	-0.8	-3.6	-0.6
Blood Red Count	0.5	4.4	22.5	1.7	-0.0	-0.7	-4.7	0.2	-0.7	2.2
Lung FVC	0.5	2.3	8.2	-0.1	-1.1	1.1	-2.9	-1.4	-1.5	1.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	-0.1	0.3	-0.8	-0.9	-1.2	-0.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.6	-0.5	-0.1	1.2	1.9	-0.1	-0.0	0.6
Pain all over the body in last month	0.5	0.5	1.2	-0.7	0.4	-1.1	1.0	0.0	-0.3	0.8
Time employed in main current job	0.5	0.6	1.6	0.5	-0.0	0.3	0.6	1.2	0.6	-1.3
Peak expiratory flow (PEF)	0.5	1.2	2.4	1.4	0.7	1.5	-1.1	1.0	-0.4	1.0
Eye problems/disorders: None of the above	0.5	0.6	1.5	-0.3	0.0	1.2	-0.8	-1.0	-1.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.5	0.8	-0.3	-0.3	0.1	0.7	0.2	-1.6
Illnesses of father: Heart disease	0.5	0.7	2.5	-1.0	1.2	-0.1	1.6	0.4	0.4	-0.0
Eye problems/disorders: Cataract	0.5	0.6	1.7	-0.1	-0.4	-0.8	-0.1	0.2	1.3	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	0.1	0.4	0.9	-0.7	-0.9	0.5	1.0
Sensitivity / hurt feelings	0.4	0.7	2.3	-1.3	0.5	0.4	1.5	-0.5	0.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.8	-0.4	-0.1	0.9	1.7	0.3	0.1	0.1
Alcohol intake versus 10 years previously	0.4	0.7	1.7	1.3	0.7	0.2	-0.4	0.8	1.3	-0.4
Headache pain in last month	0.4	0.7	1.6	1.2	-0.5	0.1	-0.2	1.1	0.0	-1.3
Worry too long after embarrassment	0.4	0.7	2.7	-0.1	1.1	1.6	0.5	-0.5	-0.3	-0.3
Medication: Ibuprofen	0.4	0.5	1.8	1.3	-0.5	-0.3	-1.1	0.3	-0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.7	0.3	0.4	-0.6	1.3	0.5	0.0	-0.9
Medication: Paracetamol	0.4	0.6	2.7	-0.0	-1.0	-1.6	-0.2	0.5	-0.4	0.2
Risk taking	0.4	0.6	1.3	0.9	1.2	0.6	-0.9	0.4	-0.1	0.7
Alzheimer’s Disease (in mother)	0.3	0.4	1.5	0.2	-0.7	-0.1	1.2	0.7	0.1	-0.4
LDL Cholesterol	0.3	0.5	1.4	0.4	-0.5	-0.0	0.8	1.2	-0.1	-1.2
Allergy or Eczema	0.3	0.9	4.8	-0.6	0.7	-0.1	2.2	-0.1	0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.6	0.0	-0.5	1.0	0.9	-0.7	0.1
Vitamin and mineral supplements	0.3	0.4	2.0	-0.6	-0.1	0.5	1.4	-0.1	0.5	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.8	-0.9	-0.0	-0.1	1.9	-0.3	0.2	-0.5
Multivitamins +/- minerals	0.3	0.4	1.0	-0.0	0.3	0.2	-1.0	-0.7	-0.8	0.6
Past tobacco smoking	0.3	0.5	1.9	-1.4	-0.2	-0.6	0.3	-1.0	-0.6	-0.2
Alcohol usually taken with meals	0.3	0.6	1.3	0.5	0.6	0.3	-1.0	-1.1	0.1	1.0
Had menopause	0.3	0.4	0.7	0.8	0.7	0.8	-0.4	0.6	-0.4	-0.0
Qualifications: None of the above	0.3	0.6	2.4	-0.6	0.2	0.3	1.6	-0.9	0.8	0.2
Happiness	0.3	0.4	1.3	0.3	-0.4	-0.4	0.1	1.2	-0.9	0.2
Medication: Lansoprazole	0.3	0.3	1.0	-0.2	-0.2	-0.4	1.0	0.6	0.3	0.6
Medication: Omeprazole	0.3	0.4	0.7	0.6	-0.5	-0.8	-0.7	0.6	-0.1	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	1.3	-0.1	-0.2	-0.9	-0.1	0.2	0.3	-1.1
Breast cancer (self-reported)	0.3	0.4	1.9	0.1	0.4	0.5	0.1	-0.4	0.0	-1.4
Mother’s age at death	0.3	0.4	1.0	0.7	0.4	0.9	-1.0	-0.5	0.2	-0.0
Ever smoked	0.3	0.5	1.3	1.1	-0.7	0.5	-0.8	0.6	-0.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	0.3	-0.7	-1.1	-0.6	0.4	-0.0	-0.6
Pain experienced in last month	0.3	0.6	1.5	-0.8	-0.2	-0.5	-1.2	-0.9	-0.8	0.2
Prostate Cancer	0.2	0.3	0.7	0.2	-0.9	0.6	-0.8	-0.1	-0.0	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.7	0.1	0.2	0.5	0.8	-0.4	-0.6
Hair Pigment	0.2	5.6	15.7	3.1	-0.9	0.7	-1.5	4.0	-1.1	-3.0
Impedance of leg (right)	0.2	1.1	2.5	0.3	-1.2	1.4	-1.2	-1.6	-0.7	-0.0
Relative age voice broke	0.2	0.4	0.9	0.4	-0.6	0.0	-0.9	-0.1	-0.5	0.9
Impedance of leg (left)	0.2	1.0	2.5	0.1	-1.6	1.0	-0.7	-1.4	-0.9	-0.0
Had other major operations	0.2	0.3	0.8	0.4	-0.0	0.5	-0.1	0.6	0.6	-0.9
Impedance of arm (right)	0.2	1.0	2.1	0.8	-1.4	-1.4	-0.6	1.2	-0.6	-0.3
Impedance of arm (left)	0.2	1.1	2.6	0.5	-1.5	-1.6	-0.4	1.4	-0.5	-0.6
Gout (self-reported)	0.2	0.3	1.3	-0.6	0.3	-0.1	1.1	-0.1	0.2	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.1	-0.5	0.1	0.1	1.0	-0.1	0.6	-0.2
Number of children fathered	0.2	0.3	1.3	0.4	-0.3	-1.1	0.0	0.5	0.0	0.2
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.4	-0.0	0.5	0.6	-0.6	0.6	-0.8
Had major operations	0.2	0.3	0.7	-0.6	-0.5	-0.8	0.1	0.3	-0.5	-0.4
Impedance of whole body	0.2	0.8	4.2	0.2	-2.1	-0.7	-0.4	0.2	-0.9	-0.4
Lung FEV1/FVC ratio	0.1	0.5	1.5	0.2	0.2	-0.7	-1.2	0.4	-0.9	0.4
Tanning	0.1	0.9	1.8	-0.9	0.4	1.3	1.0	-1.2	-0.9	-0.2

Hub : Genes

PTPRJ

Models

Trait associations