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chr16:19,022,448-21,147,999

Best TWAS P=1.07e-14 · Best GWAS P=6.72e-13 conditioned to 1.29e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	-7.1	7.7	1.1e-14	0.31	0.02	0.96	TRUE
17	GTEx	Skin Sun Exposed Lower leg	ACSM5	0.21	0.04	lasso	9	0.07	3.6e-06	1.1	-5.1	2.8e-07	0.04	0.35	0.16	TRUE
26	The Cancer Genome Atlas	Thyroid Carcinoma	GPRC5B	0.06	0.01	blup	38	0.01	2.4e-02	-4.2	-6.5	8.0e-11	-0.43	0.01	0.08	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	-5.9	-6.2	4.1e-10	-0.25	0.03	0.94	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	-4.2	-5.8	6.1e-09	-0.27	0.95	0.05	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	-5.1	-5.8	8.5e-09	-0.27	0.34	0.66	FALSE
6	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	-5.8	-5.7	1.5e-08	-0.22	0.15	0.84	FALSE
13	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	-4.2	-5.6	2.5e-08	-0.27	0.72	0.16	FALSE
5	GTEx	Brain Putamen basal ganglia	AC002550.5	0.59	0.48	enet	23	0.58	1.2e-16	-4.4	-5.5	2.9e-08	-0.19	1.00	0.00	FALSE
19	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	-4.4	-5.5	3.2e-08	-0.22	0.59	0.36	FALSE
10	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	-4.4	-5.4	6.2e-08	-0.21	0.96	0.04	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	-6.0	-5.4	7.3e-08	-0.22	0.04	0.86	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCK	0.04	0.01	blup	73	0.01	1.8e-02	-4.3	-5.4	7.8e-08	-0.23	0.08	0.35	FALSE
9	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	-4.4	-5.3	1.0e-07	-0.27	0.77	0.23	FALSE
2	GTEx	Adipose Subcutaneous	ACSM5	0.14	0.00	lasso	8	0.02	6.4e-03	5.7	-5.3	1.1e-07	-0.50	0.05	0.73	FALSE
15	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	-4.2	-5.3	1.1e-07	-0.20	0.85	0.15	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	AC002550.5	0.44	0.43	enet	24	0.43	1.2e-25	-4.2	-5.3	1.1e-07	-0.20	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCK	0.04	0.03	lasso	2	0.04	7.5e-05	-4.4	-5.3	1.2e-07	-0.29	0.23	0.28	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCK	0.03	0.03	blup	73	0.03	1.6e-07	-4.2	-5.3	1.3e-07	-0.24	0.70	0.30	FALSE
14	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	-4.2	-5.2	1.5e-07	-0.24	0.98	0.02	FALSE
8	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	-4.4	-5.2	1.6e-07	-0.21	0.44	0.56	FALSE
4	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	-4.4	-5.2	1.8e-07	-0.22	0.24	0.76	FALSE
7	GTEx	Breast Mammary Tissue (Female)	AC002550.5	0.36	0.26	enet	19	0.33	1.3e-10	-5.1	-5.2	1.8e-07	-0.23	0.69	0.30	FALSE
3	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	-4.4	-5.2	2.2e-07	-0.22	1.00	0.00	FALSE
18	GTEx	Stomach	KNOP1	0.28	0.21	lasso	6	0.21	1.8e-10	-3.8	-5.1	2.7e-07	-0.22	0.29	0.71	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	-5.1	-5.1	3.0e-07	-0.22	0.01	0.98	FALSE