Best TWAS P=1.46e-09 · Best GWAS P=2.68e-08 conditioned to 0.161
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.5 | -5.1 | 2.7e-07 | -0.96 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | RABEP1 | 0.19 | -0.01 | lasso | 13 | 0.00 | 4.2e-01 | 4.7 | -5.7 | 1.6e-08 | -0.82 | 0.03 | 0.80 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.5 | -5.3 | 8.6e-08 | -0.94 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | RABEP1 | 0.13 | 0.10 | enet | 11 | 0.12 | 7.2e-06 | 5.0 | -5.2 | 2.0e-07 | -0.85 | 0.05 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.5 | -5.8 | 7.4e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | NUP88 | 0.12 | 0.07 | enet | 12 | 0.09 | 1.2e-03 | 4.7 | -5.6 | 2.0e-08 | -0.78 | 0.02 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.9 | -6.0 | 1.5e-09 | -0.77 | 0.05 | 0.85 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | RABEP1 | 0.04 | 0.03 | enet | 5 | 0.03 | 1.5e-03 | -4.0 | -5.1 | 2.7e-07 | -0.67 | 0.09 | 0.82 | FALSE |