TWAS
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Models
Genes
Traits
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Traits
:
Basal metabolic rate
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chr2:182,305,254-184,594,404
Best TWAS P=5.09e-10 · Best GWAS P=3.4e-12 conditioned to 0.000726
182.5M
183M
183.5M
184M
184.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Hypothalamus
PDE1A
0.24
-0.01
enet
21
-0.01
0.75800
5.3
6.2
5.1e-10
0.59
0.08
0.21
TRUE
2
GTEx
Liver
NCKAP1
0.50
-0.01
lasso
10
0.01
0.14300
4.4
5.5
5.2e-08
0.11
0.05
0.08
TRUE
3
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
PDE1A
0.05
0.04
blup
206
0.04
0.00005
-4.7
5.3
9.3e-08
0.42
0.65
0.03
FALSE