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chr2:197,745,121-201,571,143

Best TWAS P=9.13e-11 · Best GWAS P=8.43e-13 conditioned to 0.00021

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	-6.6	6.5	9.1e-11	-0.86	0.13	0.87	TRUE
4	GTEx	Brain Hippocampus	FTCDNL1	0.35	0.24	enet	24	0.26	9.0e-07	-3.9	-5.8	9.0e-09	-0.10	0.31	0.19	TRUE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf60	0.03	0.03	blup	44	0.03	1.8e-04	-5.5	5.7	1.0e-08	-0.05	0.01	0.98	TRUE
12	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	-6.0	-6.4	1.6e-10	0.92	0.13	0.87	FALSE
6	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	-6.4	-6.3	3.5e-10	0.86	0.17	0.83	FALSE
9	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	-6.6	6.1	1.1e-09	-0.82	0.07	0.31	FALSE
8	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	-6.6	-6.0	1.6e-09	0.84	0.10	0.30	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	-5.8	-5.9	3.5e-09	0.86	0.39	0.61	FALSE
11	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	-6.6	-5.8	5.0e-09	0.80	0.10	0.70	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	1.7	-5.7	1.3e-08	0.65	0.05	0.38	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	TYW5	0.11	0.12	lasso	5	0.11	5.5e-14	-5.5	5.7	1.4e-08	-0.04	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TYW5	0.08	0.14	lasso	8	0.13	2.2e-15	-5.5	5.7	1.6e-08	-0.05	0.01	0.99	FALSE
10	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	-6.4	-5.6	1.8e-08	0.76	0.21	0.48	FALSE
17	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C2orf60	0.04	0.05	lasso	5	0.03	2.1e-03	-5.5	5.5	4.7e-08	-0.04	0.01	0.90	FALSE
3	GTEx	Brain Caudate basal ganglia	TYW5	0.23	0.11	lasso	3	0.11	5.4e-04	-4.7	5.4	5.6e-08	-0.03	0.03	0.68	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	C2orf47	0.25	0.01	lasso	3	0.00	2.8e-01	4.8	-5.4	6.0e-08	0.04	0.07	0.30	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	C2orf69	0.07	0.04	enet	13	0.06	3.6e-08	-5.1	5.3	1.3e-07	-0.05	0.04	0.96	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	-3.4	-5.1	2.9e-07	0.70	0.04	0.40	FALSE