Best TWAS P=9.55e-10 · Best GWAS P=1.54e-09 conditioned to 0.0511
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | 5.3 | -5.6 | 2.4e-08 | -0.44 | 0.28 | 0.72 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | 5.7 | -5.6 | 1.9e-08 | -0.81 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Aorta | RP13-514E23.2 | 0.26 | 0.09 | lasso | 6 | 0.10 | 2.2e-06 | -5.3 | -5.3 | 1.3e-07 | -0.05 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Artery Tibial | RP13-514E23.2 | 0.22 | 0.16 | enet | 10 | 0.18 | 1.2e-13 | -5.3 | -5.3 | 8.7e-08 | -0.04 | 0.06 | 0.94 | TRUE |
| 5 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | 5.8 | -6.1 | 9.5e-10 | -0.74 | 0.02 | 0.95 | TRUE |
| 6 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | 5.9 | 5.8 | 7.8e-09 | 0.81 | 0.01 | 0.99 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | 5.3 | -5.7 | 1.0e-08 | -0.45 | 0.25 | 0.75 | FALSE |