Best TWAS P=1.47e-15 · Best GWAS P=1.07e-16 conditioned to 0.588
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC35E2 | 0.35 | 0.15 | enet | 24 | 0.17 | 1.0e-20 | 6.9 | -6.4 | 1.9e-10 | -0.71 | 0.99 | 0.01 | FALSE |
2 | GTEx | Adipose Subcutaneous | C1orf86 | 0.15 | 0.05 | enet | 10 | 0.04 | 2.0e-04 | 3.0 | 5.7 | 1.6e-08 | 0.37 | 0.38 | 0.14 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | 1.5 | 6.0 | 1.5e-09 | 0.21 | 0.15 | 0.07 | TRUE |
4 | GTEx | Brain Caudate basal ganglia | RP4-758J18.10 | 0.20 | -0.01 | lasso | 5 | 0.03 | 5.6e-02 | 7.1 | -5.3 | 1.2e-07 | -0.50 | 0.03 | 0.30 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | 7.4 | 7.6 | 2.3e-14 | 0.85 | 0.02 | 0.70 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | 8.2 | -8.0 | 1.5e-15 | -0.91 | 0.01 | 0.75 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | CDK11B | 0.10 | 0.06 | lasso | 4 | 0.05 | 2.1e-04 | -1.9 | 6.0 | 1.5e-09 | 0.85 | 0.03 | 0.89 | FALSE |
8 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | 6.7 | -6.8 | 8.2e-12 | -0.83 | 0.99 | 0.01 | FALSE |
9 | GTEx | Heart Atrial Appendage | NADK | 0.19 | 0.00 | lasso | 5 | 0.00 | 3.1e-01 | 6.9 | 5.1 | 2.8e-07 | 0.62 | 0.03 | 0.32 | FALSE |
10 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | -6.3 | 7.4 | 1.3e-13 | 0.94 | 0.02 | 0.93 | FALSE |
11 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | 7.4 | 7.5 | 4.3e-14 | 0.79 | 0.05 | 0.85 | FALSE |
12 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | 7.7 | -7.5 | 7.5e-14 | -0.84 | 0.35 | 0.65 | FALSE |
13 | GTEx | Pancreas | TMEM52 | 0.19 | 0.00 | enet | 30 | 0.00 | 2.6e-01 | 1.4 | 5.5 | 3.1e-08 | 0.59 | 0.02 | 0.76 | FALSE |
14 | GTEx | Pituitary | NADK | 0.21 | 0.09 | enet | 15 | 0.07 | 9.5e-03 | 7.7 | 6.2 | 5.5e-10 | 0.67 | 0.03 | 0.56 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | -6.3 | -6.9 | 5.0e-12 | -0.92 | 0.03 | 0.97 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | -7.3 | -7.4 | 1.0e-13 | -0.92 | 0.05 | 0.95 | FALSE |
17 | GTEx | Spleen | TMEM52 | 0.47 | 0.21 | lasso | 5 | 0.22 | 2.3e-06 | 3.5 | 5.2 | 2.1e-07 | 0.58 | 0.25 | 0.36 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | 4.7 | -6.9 | 6.3e-12 | -0.70 | 1.00 | 0.00 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | 6.9 | 6.8 | 7.4e-12 | 0.80 | 0.06 | 0.93 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | SLC35E2 | 0.03 | 0.00 | blup | 291 | 0.01 | 1.4e-02 | 1.4 | -5.4 | 8.0e-08 | -0.73 | 0.03 | 0.66 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35E2 | 0.03 | 0.03 | blup | 35 | 0.01 | 7.0e-02 | 8.1 | 7.1 | 1.4e-12 | 0.95 | 0.01 | 0.99 | FALSE |
22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | 7.0 | -7.2 | 5.2e-13 | -0.91 | 0.01 | 0.81 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC35E2 | 0.03 | 0.00 | blup | 34 | 0.01 | 5.3e-02 | 7.1 | -7.0 | 3.1e-12 | -0.82 | 0.02 | 0.55 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC35E2 | 0.04 | 0.03 | lasso | 5 | 0.05 | 1.4e-06 | 7.1 | -6.1 | 1.2e-09 | -0.79 | 0.02 | 0.98 | FALSE |