Best TWAS P=1.15e-15 · Best GWAS P=1.09e-13 conditioned to 6.83e-12
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EXOSC10 | 0.06 | 0.08 | lasso | 2 | 0.07 | 6.8e-09 | -5.7 | -5.6 | 1.8e-08 | 0.00 | 0.98 | 0.02 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP4-635E18.7 | 0.19 | 0.08 | lasso | 6 | 0.05 | 9.0e-04 | -5.7 | -5.3 | 1.1e-07 | 0.01 | 0.44 | 0.03 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | -4.4 | -5.9 | 3.5e-09 | 0.02 | 0.06 | 0.14 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | EXOSC10 | 0.23 | 0.10 | lasso | 3 | 0.12 | 6.4e-04 | -5.0 | -5.5 | 3.6e-08 | 0.02 | 0.19 | 0.05 | FALSE |
5 | GTEx | Brain Cerebellum | EXOSC10 | 0.33 | 0.16 | lasso | 6 | 0.18 | 3.8e-06 | -5.8 | -5.7 | 1.6e-08 | 0.00 | 0.77 | 0.02 | FALSE |
6 | GTEx | Brain Cerebellum | RP4-635E18.7 | 0.17 | 0.17 | lasso | 5 | 0.09 | 1.3e-03 | -5.8 | -5.9 | 4.2e-09 | 0.02 | 0.38 | 0.04 | FALSE |
7 | GTEx | Brain Cortex | RP4-635E18.7 | 0.17 | 0.05 | lasso | 4 | 0.07 | 6.4e-03 | -5.2 | -5.2 | 2.1e-07 | 0.00 | 0.18 | 0.04 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | UBE4B | 0.09 | 0.00 | enet | 21 | 0.00 | 1.4e-01 | -5.3 | -5.6 | 2.6e-08 | -0.01 | 0.05 | 0.10 | FALSE |
9 | GTEx | Esophagus Mucosa | KIF1B | 0.10 | 0.00 | enet | 17 | 0.01 | 1.2e-01 | -5.3 | -8.0 | 1.1e-15 | 0.08 | 0.17 | 0.25 | TRUE |
10 | GTEx | Lung | EXOSC10 | 0.11 | 0.07 | lasso | 4 | 0.05 | 1.2e-04 | -5.8 | -5.7 | 1.4e-08 | 0.02 | 0.87 | 0.02 | FALSE |
11 | GTEx | Muscle Skeletal | KIF1B | 0.04 | 0.08 | lasso | 1 | 0.07 | 3.1e-07 | -6.4 | -6.4 | 1.6e-10 | -0.06 | 0.83 | 0.16 | FALSE |
12 | GTEx | Nerve Tibial | KIF1B | 0.10 | 0.07 | lasso | 6 | 0.04 | 8.5e-04 | -5.2 | -5.6 | 2.5e-08 | -0.09 | 0.89 | 0.05 | FALSE |
13 | GTEx | Thyroid | KIF1B | 0.13 | 0.14 | lasso | 5 | 0.16 | 5.3e-12 | -6.4 | -6.0 | 1.5e-09 | -0.07 | 0.90 | 0.10 | FALSE |
14 | GTEx | Thyroid | RP4-635E18.7 | 0.07 | 0.02 | lasso | 2 | 0.01 | 5.5e-02 | -5.8 | -6.7 | 2.2e-11 | 0.03 | 0.17 | 0.11 | TRUE |
15 | METSIM | Adipose | MTOR | 0.04 | 0.02 | bslmm | 434 | 0.02 | 1.5e-04 | -5.2 | -5.6 | 2.0e-08 | 0.08 | 0.89 | 0.01 | FALSE |
16 | NTR | Blood | KIF1B | 0.11 | 0.08 | enet | 11 | 0.09 | 3.7e-28 | 6.9 | 6.1 | 1.2e-09 | -0.06 | 0.04 | 0.96 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | EXOSC10 | 0.06 | 0.06 | lasso | 2 | 0.06 | 4.9e-08 | -5.7 | -5.6 | 1.7e-08 | 0.01 | 0.98 | 0.02 | FALSE |
18 | ROSMAP | Brain Pre-frontal Cortex | MTOR | 0.07 | 0.05 | bslmm | 423 | 0.04 | 2.0e-06 | -5.2 | -6.0 | 2.0e-09 | -0.01 | 1.00 | 0.00 | FALSE |
19 | YFS | Blood | KIF1B | 0.30 | 0.26 | enet | 49 | 0.29 | 7.8e-97 | 6.9 | 5.9 | 3.4e-09 | -0.11 | 0.05 | 0.95 | FALSE |
20 | YFS | Blood | SPSB1 | 0.03 | 0.03 | bslmm | 425 | 0.03 | 1.5e-09 | 5.9 | 5.8 | 5.8e-09 | 0.04 | 0.18 | 0.82 | TRUE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTOR | 0.02 | 0.02 | blup | 54 | 0.02 | 5.4e-03 | -5.5 | -5.5 | 3.1e-08 | 0.00 | 0.05 | 0.74 | FALSE |
22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MTOR | 0.03 | 0.01 | blup | 54 | 0.02 | 5.9e-03 | -5.5 | -5.6 | 2.6e-08 | -0.01 | 0.03 | 0.74 | FALSE |