Best TWAS P=2.03e-11 · Best GWAS P=9.12e-14 conditioned to 0.000543
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | 3.9 | -5.4 | 5.1e-08 | -0.71 | 0.03 | 0.64 | FALSE |
2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | 6.4 | 5.9 | 4.6e-09 | 0.64 | 0.13 | 0.66 | FALSE |
3 | GTEx | Brain Cerebellum | RP11-446E9.1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 3.7e-02 | 5.8 | -5.7 | 1.2e-08 | -0.54 | 0.05 | 0.48 | FALSE |
4 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | 6.5 | 6.7 | 2.0e-11 | 0.81 | 0.18 | 0.70 | TRUE |
5 | GTEx | Muscle Skeletal | RPS20 | 0.07 | 0.09 | lasso | 1 | 0.07 | 1.5e-07 | 5.7 | 5.7 | 1.2e-08 | 0.52 | 0.92 | 0.08 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | 6.1 | 6.4 | 1.7e-10 | 0.80 | 0.14 | 0.50 | FALSE |
7 | GTEx | Stomach | RP11-446E9.1 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.7e-02 | 5.3 | -5.2 | 1.8e-07 | -0.51 | 0.26 | 0.19 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | 6.4 | 5.6 | 2.8e-08 | 0.55 | 0.76 | 0.24 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | 5.7 | -6.2 | 6.0e-10 | -0.56 | 0.92 | 0.08 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | 6.3 | 5.2 | 2.3e-07 | 0.51 | 0.00 | 0.83 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | 6.4 | 6.3 | 3.7e-10 | 0.52 | 0.00 | 1.00 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | 6.4 | 6.6 | 3.7e-11 | 0.60 | 0.00 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | LYN | 0.09 | 0.12 | lasso | 2 | 0.12 | 8.4e-12 | 5.3 | -5.2 | 2.0e-07 | -0.53 | 0.44 | 0.56 | FALSE |