Best TWAS P=3.1e-12 · Best GWAS P=7.22e-11 conditioned to 0.219
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 5.3 | -5.6 | 1.8e-08 | 0.58 | 0.11 | 0.89 | FALSE |
2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -6.3 | -5.9 | 2.8e-09 | 0.84 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | GKAP1 | 0.15 | 0.02 | enet | 24 | 0.03 | 6.0e-03 | 2.4 | -6.6 | 4.7e-11 | 0.17 | 0.09 | 0.62 | FALSE |
4 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -6.3 | -6.7 | 2.2e-11 | 0.90 | 0.01 | 0.99 | FALSE |
5 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -6.1 | -5.8 | 8.6e-09 | 0.92 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 5.8 | -6.5 | 5.9e-11 | 0.75 | 0.03 | 0.74 | FALSE |
7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -6.3 | -6.3 | 2.5e-10 | 0.95 | 0.01 | 0.77 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | -6.4 | -5.9 | 2.8e-09 | 0.81 | 0.01 | 0.97 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 5.9 | -6.8 | 1.1e-11 | 0.83 | 0.03 | 0.89 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 5.8 | -6.2 | 7.7e-10 | 0.65 | 0.09 | 0.65 | FALSE |
11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN1 | 0.22 | 0.02 | lasso | 3 | 0.09 | 3.5e-03 | 6.0 | -7.0 | 3.1e-12 | 0.37 | 0.01 | 0.70 | TRUE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -6.1 | -6.9 | 4.5e-12 | 0.86 | 0.01 | 0.95 | TRUE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UBQLN1 | 0.06 | 0.00 | blup | 62 | 0.02 | 1.3e-02 | -3.7 | -6.5 | 7.4e-11 | 0.39 | 0.03 | 0.41 | FALSE |
14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -6.5 | 5.6 | 1.8e-08 | -0.86 | 0.01 | 0.89 | FALSE |