Best TWAS P=1.33e-15 · Best GWAS P=3.25e-15 conditioned to 0.0756
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | AMIGO1 | 0.17 | 0.00 | enet | 10 | 0.00 | 4.4e-01 | 5.78 | -5.8 | 6.8e-09 | 0.56 | 0.08 | 0.17 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SYPL2 | 0.28 | 0.04 | lasso | 5 | 0.09 | 2.7e-03 | -7.54 | -7.1 | 1.5e-12 | 0.90 | 0.06 | 0.89 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | ATXN7L2 | 0.24 | -0.01 | enet | 9 | -0.01 | 5.3e-01 | -3.59 | -6.9 | 5.9e-12 | 0.64 | 0.04 | 0.33 | FALSE |
4 | GTEx | Brain Cerebellum | SYPL2 | 0.16 | 0.02 | enet | 9 | 0.03 | 5.1e-02 | -7.52 | -7.7 | 1.7e-14 | 0.92 | 0.04 | 0.89 | FALSE |
5 | GTEx | Brain Cortex | AC000032.2 | 0.37 | 0.01 | enet | 17 | 0.13 | 2.1e-04 | -0.89 | -5.3 | 1.0e-07 | 0.39 | 0.09 | 0.15 | FALSE |
6 | GTEx | Breast Mammary Tissue | AMIGO1 | 0.24 | 0.21 | lasso | 2 | 0.21 | 6.1e-11 | -5.04 | -5.1 | 2.7e-07 | 0.34 | 1.00 | 0.00 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | AMIGO1 | 0.39 | 0.38 | enet | 22 | 0.43 | 1.7e-34 | -5.04 | -5.6 | 2.0e-08 | 0.39 | 1.00 | 0.00 | FALSE |
8 | GTEx | Colon Sigmoid | SYPL2 | 0.15 | 0.06 | enet | 16 | 0.06 | 5.2e-03 | -6.50 | -7.0 | 2.3e-12 | 0.76 | 0.10 | 0.79 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | SYPL2 | 0.29 | 0.14 | enet | 21 | 0.18 | 3.0e-07 | -7.52 | -5.9 | 4.6e-09 | 0.81 | 0.08 | 0.91 | FALSE |
10 | GTEx | Esophagus Mucosa | SYPL2 | 0.10 | 0.00 | enet | 26 | 0.03 | 4.5e-03 | -7.46 | -5.9 | 4.2e-09 | 0.78 | 0.06 | 0.86 | FALSE |
11 | GTEx | Esophagus Mucosa | AMIGO1 | 0.43 | 0.38 | enet | 39 | 0.39 | 2.0e-27 | -5.04 | -5.2 | 2.4e-07 | 0.40 | 1.00 | 0.00 | FALSE |
12 | GTEx | Esophagus Muscularis | SYPL2 | 0.32 | 0.23 | lasso | 10 | 0.37 | 6.8e-24 | -7.80 | -6.2 | 5.0e-10 | 0.80 | 0.03 | 0.97 | FALSE |
13 | GTEx | Liver | SYPL2 | 0.34 | 0.27 | lasso | 5 | 0.30 | 4.6e-09 | -7.54 | -8.0 | 1.3e-15 | 0.88 | 0.04 | 0.96 | TRUE |
14 | GTEx | Liver | ATXN7L2 | 0.39 | 0.04 | lasso | 12 | 0.21 | 1.3e-06 | -7.54 | -7.0 | 2.7e-12 | 0.74 | 0.04 | 0.88 | FALSE |
15 | GTEx | Liver | AMIGO1 | 0.28 | 0.13 | lasso | 7 | 0.15 | 6.9e-05 | -5.04 | -5.9 | 2.9e-09 | 0.50 | 0.24 | 0.20 | FALSE |
16 | GTEx | Lung | SYPL2 | 0.24 | 0.20 | enet | 16 | 0.28 | 1.6e-21 | -6.50 | -6.4 | 1.5e-10 | 0.84 | 0.33 | 0.67 | FALSE |
17 | GTEx | Lung | AMIGO1 | 0.14 | 0.07 | enet | 22 | 0.06 | 3.6e-05 | -5.04 | -6.0 | 1.7e-09 | 0.45 | 0.99 | 0.01 | FALSE |
18 | GTEx | Muscle Skeletal | SYPL2 | 0.20 | 0.21 | lasso | 2 | 0.21 | 1.5e-20 | -6.39 | -6.4 | 1.5e-10 | 0.77 | 1.00 | 0.00 | FALSE |
19 | GTEx | Muscle Skeletal | CYB561D1 | 0.07 | 0.00 | lasso | 3 | 0.00 | 7.2e-01 | -7.80 | 7.7 | 1.3e-14 | -0.99 | 0.03 | 0.92 | FALSE |
20 | GTEx | Nerve Tibial | AMIGO1 | 0.36 | 0.33 | lasso | 6 | 0.33 | 4.4e-24 | -5.04 | -5.1 | 2.9e-07 | 0.35 | 1.00 | 0.00 | FALSE |
21 | GTEx | Ovary | SYPL2 | 0.39 | 0.44 | lasso | 5 | 0.46 | 8.8e-13 | -7.85 | 7.9 | 3.4e-15 | -0.97 | 0.03 | 0.97 | FALSE |
22 | GTEx | Ovary | ATXN7L2 | 0.18 | 0.18 | enet | 17 | 0.13 | 5.6e-04 | -7.85 | 8.0 | 1.8e-15 | -0.99 | 0.03 | 0.94 | FALSE |
23 | GTEx | Pancreas | SYPL2 | 0.28 | 0.23 | lasso | 5 | 0.19 | 2.0e-08 | -6.53 | -7.1 | 1.3e-12 | 0.92 | 0.05 | 0.95 | FALSE |
24 | GTEx | Skin Not Sun Exposed Suprapubic | AMIGO1 | 0.43 | 0.36 | lasso | 6 | 0.33 | 7.7e-19 | -5.04 | -5.3 | 1.4e-07 | 0.40 | 1.00 | 0.00 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | AMIGO1 | 0.39 | 0.36 | enet | 26 | 0.40 | 1.0e-35 | -5.04 | -5.8 | 7.8e-09 | 0.38 | 1.00 | 0.00 | FALSE |
26 | GTEx | Stomach | SYPL2 | 0.23 | 0.18 | lasso | 8 | 0.21 | 2.3e-10 | -7.54 | -7.6 | 2.6e-14 | 0.90 | 0.04 | 0.96 | FALSE |
27 | GTEx | Stomach | AMIGO1 | 0.15 | 0.07 | lasso | 3 | 0.06 | 8.1e-04 | -5.04 | -5.8 | 7.7e-09 | 0.47 | 0.46 | 0.18 | FALSE |
28 | GTEx | Testis | SORT1 | 0.25 | 0.17 | lasso | 6 | 0.17 | 5.2e-08 | -6.53 | -6.3 | 2.6e-10 | 0.84 | 0.09 | 0.90 | FALSE |
29 | GTEx | Testis | SYPL2 | 0.45 | 0.50 | enet | 22 | 0.54 | 5.0e-28 | -7.76 | 7.9 | 2.4e-15 | -0.99 | 0.03 | 0.97 | FALSE |
30 | GTEx | Testis | ATXN7L2 | 0.28 | 0.34 | lasso | 4 | 0.33 | 3.7e-15 | -7.87 | 7.9 | 3.8e-15 | -0.99 | 0.02 | 0.98 | FALSE |
31 | GTEx | Thyroid | ATXN7L2 | 0.15 | 0.15 | lasso | 6 | 0.15 | 1.0e-11 | -6.39 | 6.3 | 2.5e-10 | -0.76 | 0.79 | 0.21 | FALSE |
32 | GTEx | Uterus | SYPL2 | 0.29 | 0.13 | lasso | 7 | 0.04 | 5.1e-02 | -7.54 | 6.8 | 1.0e-11 | -0.85 | 0.04 | 0.71 | FALSE |
33 | METSIM | Adipose | SYPL2 | 0.06 | 0.06 | blup | 418 | 0.05 | 4.3e-08 | -6.39 | -7.3 | 3.1e-13 | 0.80 | 0.28 | 0.72 | FALSE |
34 | NTR | Blood | SORT1 | 0.05 | 0.06 | lasso | 6 | 0.06 | 2.1e-17 | -7.85 | -7.8 | 4.4e-15 | 0.98 | 0.02 | 0.98 | FALSE |
35 | ROSMAP | Brain Pre-frontal Cortex | SYPL2 | 0.03 | 0.01 | lasso | 3 | 0.01 | 9.8e-03 | -6.39 | -5.3 | 1.1e-07 | 0.66 | 0.07 | 0.64 | FALSE |
36 | ROSMAP | Brain Pre-frontal Cortex | ATXN7L2 | 0.07 | 0.06 | enet | 12 | 0.09 | 5.6e-12 | -7.52 | 5.1 | 3.1e-07 | -0.70 | 0.20 | 0.80 | FALSE |
37 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AMIGO1 | 0.10 | 0.14 | enet | 10 | 0.11 | 2.8e-09 | -5.04 | -6.3 | 2.2e-10 | 0.57 | 1.00 | 0.00 | FALSE |
38 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SYPL2 | 0.06 | 0.07 | blup | 45 | 0.08 | 8.5e-16 | -7.54 | -6.6 | 4.9e-11 | 0.86 | 0.05 | 0.95 | FALSE |
39 | The Cancer Genome Atlas | Esophageal Carcinoma | AMIGO1 | 0.24 | 0.08 | blup | 46 | 0.18 | 3.0e-06 | -4.54 | -6.5 | 6.1e-11 | 0.56 | 0.09 | 0.32 | FALSE |
40 | The Cancer Genome Atlas | Glioblastoma Multiforme | AMIGO1 | 0.20 | 0.05 | lasso | 7 | 0.07 | 3.1e-03 | -5.04 | -5.8 | 6.6e-09 | 0.51 | 0.03 | 0.33 | FALSE |
41 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AMIGO1 | 0.17 | 0.20 | enet | 9 | 0.18 | 2.1e-19 | -5.04 | -5.4 | 6.4e-08 | 0.41 | 1.00 | 0.00 | FALSE |
42 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SYPL2 | 0.03 | 0.05 | lasso | 4 | 0.05 | 6.6e-06 | -7.76 | -7.9 | 3.6e-15 | 0.98 | 0.01 | 0.99 | FALSE |
43 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SYPL2 | 0.04 | 0.04 | blup | 45 | 0.04 | 3.6e-03 | -7.49 | 6.7 | 2.7e-11 | -0.88 | 0.02 | 0.60 | FALSE |
44 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MYBPHL | 0.09 | 0.07 | blup | 46 | 0.06 | 5.7e-04 | -6.50 | -7.2 | 4.1e-13 | 0.81 | 0.01 | 0.77 | FALSE |
45 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SYPL2 | 0.18 | 0.19 | blup | 45 | 0.18 | 4.7e-09 | -7.87 | -7.4 | 1.7e-13 | 0.95 | 0.01 | 0.99 | FALSE |
46 | The Cancer Genome Atlas | Lung Adenocarcinoma | AMIGO1 | 0.10 | 0.14 | enet | 10 | 0.12 | 2.0e-13 | -5.03 | -5.7 | 1.3e-08 | 0.45 | 1.00 | 0.00 | FALSE |
47 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYPL2 | 0.09 | 0.14 | enet | 13 | 0.14 | 1.3e-16 | -7.56 | -6.8 | 1.5e-11 | 0.88 | 0.05 | 0.95 | FALSE |
48 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | AMIGO1 | 0.13 | 0.13 | blup | 46 | 0.12 | 1.7e-13 | -5.03 | -5.8 | 6.0e-09 | 0.48 | 1.00 | 0.00 | FALSE |
49 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SYPL2 | 0.05 | 0.06 | blup | 45 | 0.06 | 4.4e-07 | -7.76 | -6.6 | 3.2e-11 | 0.90 | 0.02 | 0.98 | FALSE |
50 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AMIGO1 | 0.06 | 0.00 | blup | 46 | 0.02 | 9.5e-03 | -5.34 | -6.8 | 1.0e-11 | 0.68 | 0.03 | 0.42 | FALSE |
51 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MYBPHL | 0.16 | 0.18 | enet | 10 | 0.17 | 2.3e-11 | -7.85 | -7.9 | 2.3e-15 | 0.99 | 0.01 | 0.99 | FALSE |
52 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AMIGO1 | 0.20 | 0.24 | enet | 7 | 0.16 | 2.3e-07 | -5.04 | -5.5 | 4.3e-08 | 0.43 | 0.99 | 0.01 | FALSE |
53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SYPL2 | 0.08 | 0.08 | blup | 44 | 0.10 | 1.9e-10 | -7.51 | -7.7 | 1.5e-14 | 0.92 | 0.05 | 0.95 | FALSE |
54 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CELSR2 | 0.08 | 0.00 | blup | 62 | 0.02 | 8.1e-03 | -7.80 | -6.3 | 2.1e-10 | 0.61 | 0.01 | 0.42 | FALSE |
55 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PSRC1 | 0.12 | 0.03 | enet | 6 | 0.08 | 1.5e-06 | -3.38 | -5.4 | 7.0e-08 | 0.34 | 0.16 | 0.26 | FALSE |
56 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SORT1 | 0.04 | 0.01 | blup | 60 | 0.03 | 4.4e-03 | -3.38 | -6.6 | 3.4e-11 | 0.75 | 0.02 | 0.31 | FALSE |
57 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SYPL2 | 0.05 | 0.02 | blup | 45 | 0.03 | 2.6e-03 | -7.56 | -6.5 | 1.1e-10 | 0.87 | 0.02 | 0.80 | FALSE |
58 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | AMIGO1 | 0.14 | 0.14 | blup | 46 | 0.14 | 1.1e-05 | -5.04 | -6.6 | 4.6e-11 | 0.58 | 0.39 | 0.36 | FALSE |
59 | The Cancer Genome Atlas | Thyroid Carcinoma | AMIGO1 | 0.14 | 0.16 | enet | 6 | 0.16 | 1.7e-15 | -5.04 | -5.3 | 1.0e-07 | 0.40 | 1.00 | 0.00 | FALSE |
60 | The Cancer Genome Atlas | Thyroid Carcinoma | ATXN7L2 | 0.06 | 0.06 | lasso | 3 | 0.05 | 6.6e-06 | -7.51 | 7.6 | 2.2e-14 | -0.94 | 0.02 | 0.97 | FALSE |
61 | The Cancer Genome Atlas | Thyroid Carcinoma | SYPL2 | 0.07 | 0.04 | blup | 45 | 0.03 | 4.9e-04 | -7.51 | 7.4 | 1.8e-13 | -0.89 | 0.02 | 0.97 | FALSE |