Best TWAS P=1.95e-09 · Best GWAS P=7.6e-10 conditioned to 0.111
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | USP35 | 0.06 | 0.05 | blup | 363 | 0.04 | 1.6e-05 | 4.8 | 5.2 | 2.2e-07 | 0.77 | 0.06 | 0.91 | FALSE |
2 | GTEx | Artery Aorta | GAB2 | 0.10 | 0.02 | lasso | 4 | 0.02 | 1.7e-02 | 5.7 | -5.1 | 2.9e-07 | -0.80 | 0.06 | 0.70 | FALSE |
3 | GTEx | Artery Tibial | GAB2 | 0.06 | 0.00 | lasso | 2 | 0.01 | 2.4e-02 | 5.7 | -5.7 | 1.0e-08 | -0.94 | 0.06 | 0.77 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | USP35 | 0.19 | 0.07 | enet | 13 | 0.09 | 2.5e-03 | 6.0 | 5.6 | 1.6e-08 | 0.95 | 0.06 | 0.76 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | NARS2 | 0.17 | 0.10 | lasso | 6 | 0.10 | 1.5e-03 | 4.5 | -5.2 | 1.8e-07 | -0.73 | 0.10 | 0.73 | FALSE |
6 | GTEx | Esophagus Muscularis | GAB2 | 0.05 | 0.04 | lasso | 7 | 0.04 | 1.8e-03 | 5.0 | -5.5 | 3.7e-08 | -0.77 | 0.14 | 0.76 | FALSE |
7 | GTEx | Testis | USP35 | 0.07 | 0.06 | lasso | 2 | 0.07 | 6.4e-04 | 6.0 | 6.0 | 2.1e-09 | 0.95 | 0.05 | 0.91 | FALSE |
8 | METSIM | Adipose | USP35 | 0.05 | 0.05 | lasso | 11 | 0.04 | 3.0e-06 | 5.7 | 5.9 | 4.6e-09 | 0.96 | 0.05 | 0.95 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | GAB2 | 0.05 | 0.00 | blup | 435 | 0.02 | 8.0e-04 | 5.8 | -5.4 | 8.0e-08 | -0.75 | 0.17 | 0.76 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | GAB2 | 0.10 | 0.07 | blup | 100 | 0.09 | 8.8e-04 | 6.0 | -6.0 | 2.0e-09 | -0.92 | 0.05 | 0.65 | TRUE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GAB2 | 0.06 | 0.06 | blup | 100 | 0.07 | 7.8e-08 | 5.7 | -5.9 | 4.1e-09 | -0.91 | 0.10 | 0.90 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KCTD21 | 0.03 | 0.00 | blup | 51 | 0.01 | 7.2e-02 | 6.0 | -5.4 | 8.3e-08 | -0.86 | 0.01 | 0.65 | FALSE |
13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GAB2 | 0.04 | 0.04 | blup | 100 | 0.04 | 1.4e-03 | 6.0 | -6.0 | 2.1e-09 | -0.95 | 0.04 | 0.90 | FALSE |