Hub : Genes

GAB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.0990 0.0510 6.2e-03 0.016 NA 0.024 NA 0.024 4.5e-02 NA 1.7e-02 NA 1.7e-02
2 GTEx Artery Tibial 0.0638 0.0326 8.9e-03 0.004 NA -0.003 NA 0.014 1.5e-01 NA 7.0e-01 NA 2.4e-02
3 GTEx Esophagus Muscularis 0.0540 0.0280 6.1e-03 0.041 NA 0.034 NA 0.040 1.5e-03 NA 4.0e-03 NA 1.8e-03
4 GTEx Liver 0.1680 0.0770 5.7e-03 -0.006 NA -0.007 NA -0.008 5.1e-01 NA 5.7e-01 NA 6.5e-01
5 GTEx Skin Sun Exposed Lower leg 0.0590 0.0290 1.1e-03 0.013 NA 0.028 NA 0.014 2.9e-02 NA 2.2e-03 NA 2.3e-02
6 ROSMAP Brain Pre-frontal Cortex 0.0487 0.0206 2.0e-04 0.001 0.021 0.012 0.021 0.003 2.3e-01 8.0e-04 8.3e-03 0.00092 1.2e-01
7 TCGA Glioblastoma Multiforme 0.1010 0.0720 4.1e-03 0.071 0.094 0.091 NA 0.053 3.5e-03 8.8e-04 1.0e-03 NA 1.0e-02
8 TCGA Prostate Adenocarcinoma 0.0598 0.0329 2.4e-08 0.055 0.070 0.055 NA 0.067 1.8e-06 7.8e-08 1.8e-06 NA 1.7e-07
9 TCGA Stomach Adenocarcinoma 0.0360 0.0240 1.8e-03 0.038 0.035 0.027 NA 0.032 8.5e-04 1.4e-03 4.4e-03 NA 2.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 0.9 2.9 1.0 0.8 1.0 0.0 0.9 1.7 0.3 0.7 0.9
Bipolar Disorder or Schizophrenia 2.0 4.9 9.7 2.1 2.4 1.8 -2.1 1.5 3.1 1.8 2.1 2.6
Depressed Affect (Nagel 2018) 3.1 6.5 15.1 2.0 2.2 3.2 -1.4 1.3 3.9 2.6 2.8 2.5
Depression (Nagel 2018) 2.2 3.3 9.3 1.0 1.3 2.5 -1.4 0.9 3.0 1.7 1.8 1.7
Intelligence (Savage-Jansen 2018) 0.8 2.5 12.8 -0.0 -1.2 -1.4 3.6 -0.1 -1.7 -0.8 -1.2 -1.4
Neuroticism (Nagel 2018) 6.6 15.5 25.5 4.4 3.8 4.1 -3.0 2.5 5.0 3.8 4.0 4.1
Schizophrenia (2018) 2.3 4.7 7.6 1.9 2.4 1.6 -2.8 0.9 2.6 2.0 2.1 2.6
Schizophrenia vs Biploar Disorder 0.7 0.9 2.5 -0.4 -0.8 -1.3 0.6 -1.6 -0.6 -0.8 -0.9 -1.0
Worry (Nagel 2018) 3.3 7.0 12.2 3.5 2.6 2.8 -1.4 1.7 3.3 2.4 2.5 2.9
Alzheimer’s Disease (in mother) 0.2 0.3 1.5 0.4 -0.2 -0.4 -1.2 -0.4 -0.6 0.1 0.1 -0.2
Alzheimer’s Disease (in father) 0.5 0.5 2.8 -0.7 0.2 0.4 -1.0 0.1 1.7 0.1 0.2 0.1
Alzheimer’s Disease (including proxy) 1.1 1.6 3.9 1.4 0.8 1.3 -2.0 0.6 1.2 1.3 1.4 1.0
Crohns Disease (2017) 0.6 1.2 1.8 -0.8 -1.2 -1.0 1.3 -1.3 -0.7 -1.0 -1.3 -1.1
Irritable Bowel Disease (IBD) 2.9 6.9 8.4 -2.3 -2.8 -2.6 2.1 -2.7 -2.7 -2.7 -2.9 -2.7
Ulcerative Colitis (UC) 5.2 9.8 11.6 -2.6 -3.3 -3.2 2.2 -3.1 -3.4 -3.4 -3.4 -3.3
Major Depression (MDD) 0.9 1.0 2.8 1.1 0.8 0.8 -0.1 1.4 1.7 0.7 0.8 0.8
Reaction Time 1.0 1.8 3.3 -0.5 -1.3 -1.8 0.7 -1.3 -1.8 -1.3 -1.4 -1.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 5.0 1.0 -0.0 -0.2 2.2 1.3 0.3 0.3 -0.1 0.0
Breast Cancer 1.1 2.6 5.8 -0.9 -1.2 -1.9 2.4 -1.8 -1.7 -1.3 -1.5 -1.3
Ovarian Cancer 0.6 0.8 1.2 0.5 0.8 1.0 -1.1 1.1 0.3 1.0 1.0 0.9
Prostate Cancer 0.3 0.5 1.6 -1.3 -0.4 -0.7 -0.8 -0.7 -0.2 -0.2 -0.6 -0.6
Age at First Birth 0.2 0.3 1.4 0.8 -0.0 0.7 0.3 1.2 0.5 0.1 0.3 0.3
Bipolar Disorder (2011) 0.2 0.2 0.8 0.2 0.2 0.2 0.4 0.3 0.9 0.1 -0.0 0.4
Body Mass Index (BMI) (2010) 6.0 8.3 12.2 3.3 3.5 2.3 -1.7 2.5 2.2 3.1 3.2 3.5
Coronary Artery Disease (CAD) 2.9 3.4 6.1 1.0 1.6 2.2 -1.6 1.5 2.5 1.9 2.0 2.0
Crohns Disease (2012) 0.5 0.8 1.6 -0.5 -0.9 -0.7 1.3 -1.2 -0.9 -0.7 -0.8 -0.9
Mean Putamen Volume 0.4 0.4 1.3 0.5 -0.2 -0.5 1.2 -1.0 -0.9 -0.3 -0.2 -0.3
Fasting Glucose 0.6 0.7 2.2 0.5 -1.2 -0.2 1.5 0.7 -1.1 -0.5 -0.5 -0.4
HbA1C 4.4 4.9 7.6 2.6 2.0 2.2 -1.3 1.2 2.1 2.8 2.4 2.7
HDL Cholesterol 0.1 0.1 0.3 0.4 -0.3 0.1 -0.3 -0.2 0.6 -0.6 -0.2 -0.4
LDL Cholesterol 6.7 10.6 15.7 3.3 3.8 2.8 -2.5 2.6 2.4 3.8 3.7 4.0
Lupus 0.4 0.5 1.0 -0.2 -1.0 -0.1 0.8 -1.0 0.2 -1.0 -0.9 -0.7
Neuroticism (2016) 1.9 2.7 3.8 1.5 1.3 1.3 -1.5 2.0 2.0 1.8 1.6 1.7
Primary Biliary Cirrhosis 0.3 0.4 3.3 0.3 0.0 0.1 -0.2 -1.8 0.7 -0.2 -0.2 0.1
Rheumatoid Arthritis 1.9 2.6 6.3 -0.8 -1.4 -1.8 1.1 -2.5 -1.3 -1.8 -1.7 -1.6
Schizophrenia (2014) 1.2 2.6 5.7 1.6 1.9 0.9 -1.8 0.3 2.4 1.3 1.5 1.8
Triglycerides 2.9 4.7 8.2 1.8 2.5 2.1 -1.1 2.1 1.3 2.9 2.6 2.4
Type 2 Diabetes (T2D) (2012) 2.2 2.5 4.5 -2.1 -1.8 -0.4 1.8 -2.1 -1.3 -1.3 -1.3 -1.5
Ulcerative Colitis 3.5 5.1 7.4 -1.8 -2.6 -2.1 1.5 -2.2 -2.7 -2.4 -2.3 -2.4
Blood Eosinophil Count 0.1 1.1 4.3 -2.1 -0.2 1.3 -0.9 1.1 1.1 0.2 0.3 -0.3
Blood Platelet Count 0.9 10.8 29.4 2.6 3.5 2.2 -3.3 1.6 5.4 3.0 3.0 3.5
Blood Red Count 1.6 15.3 23.2 -3.1 -4.0 -4.8 3.1 -3.1 -4.1 -4.0 -4.3 -4.2
Blood White Count 0.0 0.3 0.9 -0.3 -0.2 -0.8 -0.1 -0.9 0.6 -0.5 -0.6 -0.4
Heel T-Score 2.6 20.9 25.0 4.6 4.9 5.0 -3.2 3.8 4.8 4.7 5.0 4.8
BMI 3.0 17.3 21.1 4.2 3.9 4.6 -3.3 4.1 4.3 4.3 4.5 4.0
Height 1.1 21.3 33.6 -3.8 -4.3 -4.9 4.9 -3.5 -5.8 -4.6 -4.8 -4.4
Waist Hip Ratio (WHR) 0.7 3.4 7.7 -2.8 -1.7 -1.6 -0.9 -1.4 -1.9 -2.0 -1.9 -1.9
Systolic Blood Pressure 1.2 5.9 8.9 3.0 2.4 2.3 -2.6 0.9 2.4 2.5 2.5 2.6
Smoking Status 1.8 4.4 8.0 -2.8 -2.2 -2.0 1.0 -1.9 -1.5 -2.4 -2.2 -2.3
Allergy or Eczema 1.9 5.0 6.8 -2.5 -2.5 -2.3 1.6 -1.8 -1.3 -2.6 -2.5 -2.5
Cardiovascular Disease 3.6 11.9 16.1 2.6 3.2 3.9 -3.3 2.7 4.0 3.7 3.7 3.4
Hypothyroidism (self reported) 0.7 1.6 2.4 1.0 1.4 1.5 -0.7 1.0 1.2 1.2 1.5 1.3
Respiratory disease 2.6 5.9 11.5 -3.4 -2.4 -2.6 1.3 -1.5 -1.9 -2.8 -2.8 -2.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.8 0.8 0.5 -0.4 -1.3 0.6 -0.2 0.5 0.4 0.4
Lung FEV1/FVC ratio 9.8 49.5 66.2 4.7 7.4 8.0 -6.6 5.6 6.4 7.8 8.1 7.8
Lung FVC 0.4 2.0 4.2 -1.4 -1.1 -1.7 1.6 -2.1 -0.7 -1.3 -1.5 -1.0
Neuroticism 9.2 22.1 34.4 5.1 4.8 4.8 -2.9 3.5 5.9 4.8 4.8 5.2
Chronotype (morning person) 4.9 11.4 23.0 2.2 3.4 3.3 -3.0 3.4 4.8 3.2 3.3 3.4
Hair Pigment 13.9 397.4 484.0 18.3 21.5 20.6 -16.7 16.0 19.3 21.9 22.0 22.0
Tanning 2.6 31.6 40.7 -4.7 -6.2 -6.0 5.5 -3.2 -5.4 -6.2 -6.4 -6.3
Hand grip strength (left) 0.5 1.4 2.9 1.6 1.6 0.6 0.6 0.0 -1.0 1.2 1.4 1.7
Number of treatments/medications taken 0.1 0.1 0.3 -0.3 -0.4 0.3 -0.4 0.2 0.4 -0.3 -0.3 -0.6
Average weekly spirits intake 0.3 0.4 0.8 0.3 -0.4 -0.7 0.8 -0.4 -0.9 -0.5 -0.6 -0.6
Sensitivity / hurt feelings 7.5 12.8 15.5 3.9 3.6 3.6 -3.5 2.7 3.6 3.6 3.7 3.9
Frequency of depressed mood in last 2 weeks 2.4 3.4 8.1 0.9 1.4 2.5 -1.4 0.9 2.9 1.9 1.8 1.9
Hearing difficulty/problems: Yes 1.0 1.5 3.0 -1.2 -1.4 -0.9 1.7 -0.4 -0.7 -1.3 -1.3 -1.4
Relative age of first facial hair 1.8 3.7 5.1 -1.8 -2.0 -1.7 1.7 -1.6 -2.2 -2.3 -1.9 -2.0
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.6 -1.5 -1.3 -0.5 0.8 -1.6 -1.5 -1.2 -1.1 -1.0
Ever used hormone-replacement therapy (HRT) 0.2 0.3 2.0 -1.4 0.2 0.2 -0.5 0.1 0.3 0.2 0.2 -0.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.6 -0.2 -0.1 0.0 -0.4 -0.3 0.0 -0.1 -0.2
Systolic blood pressure, automated reading 1.1 3.2 4.7 2.2 1.9 1.6 -2.1 0.5 2.0 1.7 1.7 1.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.1 1.1 0.8 0.2 -0.6 1.0 0.7 0.7 0.6 0.7
Angina 0.9 1.2 2.1 0.2 1.1 1.5 -0.8 0.3 1.3 1.4 1.2 1.4
Medication for hormone replacement therapy 0.3 0.3 0.6 -0.8 -0.6 -0.2 0.4 0.3 -0.4 -0.6 -0.6 -0.8
Vitamin and mineral supplements 0.5 0.7 1.5 0.6 0.7 1.2 -0.3 0.5 0.8 1.1 1.2 0.7
Supplements: Zinc 0.2 0.2 0.9 1.0 0.4 -0.2 -0.5 0.1 -0.6 0.1 0.2 0.4
Medication: Co-codamol 0.2 0.3 1.0 -1.0 -0.4 0.2 -0.6 -0.7 0.4 -0.3 -0.3 -0.2
Medication: Metformin 0.1 0.2 0.7 0.5 0.3 -0.4 -0.9 0.2 -0.6 0.3 0.3 0.3
Diabetes (father) 0.1 0.2 0.9 1.0 0.1 0.4 0.0 0.0 -0.3 0.5 0.2 0.1
Diabetes (mother) 0.2 0.2 0.6 -0.7 -0.5 -0.8 -0.3 -0.1 0.2 -0.4 -0.4 -0.6
Severe depression (siblings) 1.0 1.2 2.0 -1.4 -1.0 -1.3 0.2 -0.8 -1.1 -1.1 -1.2 -1.0
Pack years adult smoking proportion 1.8 2.7 4.2 -2.1 -2.0 -1.0 1.0 -1.5 -1.1 -1.8 -1.8 -2.0
Impedance of leg (right) 1.3 6.2 7.2 -2.7 -2.5 -2.6 1.8 -2.5 -2.7 -2.5 -2.6 -2.4
Leg fat-free mass (left) 0.1 0.4 0.8 0.9 0.4 0.7 -0.5 0.8 0.1 0.6 0.7 0.4
Trunk fat percentage 0.7 2.9 6.2 -1.6 -2.3 -1.0 1.5 -0.3 -1.5 -1.9 -1.7 -2.5
Hand grip strength (right) 0.6 1.5 3.0 1.7 1.5 1.1 0.5 -0.3 -0.5 1.4 1.4 1.7
Townsend deprivation index at recruitment 6.3 8.9 13.0 -3.5 -3.6 -2.8 2.5 -1.6 -1.7 -3.1 -3.4 -3.6
Current tobacco smoking 0.4 0.7 4.8 -2.2 -0.3 -0.2 -0.1 -0.9 -0.1 -0.4 -0.2 -0.3
Average weekly fortified wine intake 5.5 6.4 8.9 -2.5 -2.6 -2.8 1.5 -1.9 -3.0 -2.7 -3.0 -2.5
Maternal smoking around birth 0.9 1.3 6.1 -0.5 0.3 0.9 -2.0 -0.1 2.5 0.2 0.5 0.3
Fed-up feelings 1.5 2.6 5.2 1.1 1.5 2.1 -0.8 0.3 2.3 1.8 1.9 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 5.2 0.5 1.1 2.1 -1.7 0.3 2.3 1.5 1.6 1.6
Relative age voice broke 0.5 0.7 1.3 -0.7 -0.8 -0.7 1.0 -0.5 -1.1 -1.1 -0.7 -0.8
Taking other prescription medications 2.0 3.0 5.7 -2.0 -2.3 -1.1 1.0 -0.1 -1.4 -2.1 -1.9 -2.4
Age when periods started (menarche) 12.0 28.7 37.2 -6.1 -5.4 -5.1 3.8 -5.9 -5.4 -5.5 -5.4 -5.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.5 0.4 0.9 -0.6 0.5 0.5 0.6 0.6 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.6 7.6 2.4 1.8 1.9 -0.3 2.8 1.4 2.0 2.0 1.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.5 -0.9 0.6 0.0 -1.9 0.5 0.8 0.3 0.5 0.8
Qualifications: CSEs or equivalent 1.4 1.9 3.2 1.4 1.4 1.4 -1.8 0.2 0.7 1.6 1.6 1.5
Serious illness, injury or assault to yourself 0.7 0.8 2.8 -1.7 -1.0 -0.8 0.4 -0.3 -0.7 -0.7 -0.9 -0.9
High blood pressure 2.7 7.6 11.4 2.6 2.8 2.8 -2.5 2.0 3.4 2.9 3.0 2.6
Hayfever, allergic rhinitis or eczema 1.6 3.5 4.4 -1.9 -2.1 -2.1 1.4 -1.7 -1.2 -2.1 -2.0 -2.1
Multivitamins +/- minerals 0.2 0.3 0.7 -0.0 -0.5 -0.7 0.2 0.3 -0.7 -0.6 -0.8 -0.5
Stomach or abdominal pain in last month 0.7 0.9 2.9 0.8 0.8 1.2 -0.3 0.5 1.7 0.8 1.0 0.8
Supplements: Glucosamine 0.4 0.5 1.2 1.1 0.8 -0.1 -0.5 1.0 0.4 0.6 0.5 0.6
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 3.0 1.7 0.8 -0.0 1.0 0.6 -0.3 0.4 0.4 0.6
Medication: Atenolol 3.2 4.0 5.7 1.5 2.3 1.7 -2.3 0.3 1.8 2.4 2.2 2.4
Medication: Levothyroxine sodium 0.5 0.8 1.9 0.7 1.0 1.1 -0.9 0.5 1.4 0.6 0.9 0.8
Sitting height 0.4 2.7 5.2 -1.4 -1.2 -2.2 0.7 -2.0 -2.3 -1.5 -1.5 -1.2
Chronic bronchitis/emphysema (father) 0.4 0.5 2.1 -0.8 -0.7 -0.1 1.4 -0.5 -0.2 -0.4 -0.6 -0.8
High blood pressure (mother) 1.5 2.1 4.5 1.2 1.8 0.3 -2.1 0.0 1.6 1.4 1.3 1.8
Body mass index (BMI) 1.9 8.3 13.2 2.7 2.4 3.6 -2.1 3.4 2.9 2.9 3.0 2.5
Impedance of leg (left) 0.7 3.4 6.1 -2.5 -1.9 -1.5 1.3 -1.8 -1.9 -1.9 -1.9 -1.8
Leg predicted mass (left) 0.1 0.4 0.9 0.9 0.4 0.7 -0.5 0.8 0.1 0.6 0.7 0.4
Trunk fat mass 0.2 0.9 2.2 -0.6 -1.3 -0.2 0.8 0.4 -1.0 -1.0 -0.8 -1.5
Waist circumference 0.1 0.3 1.6 0.3 0.0 0.8 -0.5 1.3 0.1 0.3 0.4 -0.0
Number of incorrect matches in round 1.0 1.6 3.9 1.5 1.3 0.7 -2.0 1.3 0.6 1.1 1.1 1.1
Past tobacco smoking 0.9 1.6 2.5 1.1 1.1 1.6 -0.9 0.5 1.6 1.3 1.4 1.4
Alcohol usually taken with meals 4.2 6.8 10.4 2.7 2.9 2.6 -2.0 2.1 1.6 3.0 2.7 3.2
Nervous feelings 0.3 0.5 3.3 0.9 0.2 -0.2 0.1 -1.8 0.1 -0.4 -0.2 0.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 4.0 1.4 1.0 1.5 -0.7 0.1 2.0 1.0 1.1 1.2
Hearing difficulty/problems with background noise 0.1 0.2 0.8 -0.4 -0.0 -0.2 0.4 -0.9 0.5 -0.3 0.0 -0.0
Hair/balding pattern: Pattern 2 5.3 6.7 9.7 -1.8 -2.9 -2.5 1.8 -2.8 -2.6 -2.7 -2.8 -3.1
Had menopause 1.4 1.7 6.1 0.6 1.2 1.5 -0.4 2.5 1.1 1.3 1.2 1.1
Had other major operations 0.7 0.8 1.6 0.7 0.8 1.2 0.8 1.3 0.8 0.7 1.1 0.7
Forced vital capacity (FVC) 0.5 1.8 5.2 0.4 -0.6 -1.6 1.7 -1.8 -2.3 -0.7 -0.9 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.6 8.6 2.9 2.3 2.5 -0.4 2.6 2.1 2.5 2.7 2.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.1 -0.8 -1.3 -1.0 0.2 -0.8 -0.9 -1.4 -1.2 -1.3
Qualifications: None of the above 0.3 0.7 1.9 -1.3 -0.4 0.3 -1.1 -1.4 0.7 -0.3 -0.3 -0.5
Financial difficulties in last 2 years 1.2 1.7 3.1 -0.4 -1.7 -1.3 0.5 -0.4 -1.3 -1.5 -1.8 -1.7
Mouth/teeth dental problems 0.4 0.6 2.0 1.0 0.7 0.1 -1.4 0.3 0.0 0.7 0.7 0.8
Heart attack 0.5 0.6 1.4 -1.2 -1.0 -0.6 -0.4 -0.6 -0.6 -0.7 -0.8 -0.8
Allergy 2.2 5.2 7.8 2.8 2.5 2.2 -1.7 1.8 1.2 2.6 2.5 2.5
Pain all over the body in last month 1.2 1.3 2.0 -1.0 -1.1 -1.2 0.2 -1.4 -1.1 -1.3 -1.2 -1.2
Diabetes (self-reported) 0.1 0.1 0.3 0.1 0.1 -0.5 -0.5 0.3 -0.6 0.2 0.2 0.0
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 1.9 1.2 0.9 1.4 -1.3 1.1 1.0 1.1 1.2 1.0
Medication: Ramipril 0.3 0.4 1.7 0.5 0.3 0.7 -0.1 1.3 0.2 0.8 0.7 0.4
Medication: Simvastatin 0.2 0.3 1.4 -1.2 -0.3 -0.6 0.0 0.5 -0.7 -0.2 -0.2 -0.2
Fluid intelligence score 0.4 0.9 5.3 1.0 0.2 0.3 2.3 1.1 0.5 0.5 0.1 0.3
Illnesses of siblings 0.4 0.5 2.9 1.7 0.2 0.3 0.6 0.2 -0.8 0.4 0.4 0.4
Neuroticism score 2.5 5.3 9.5 2.9 2.0 2.7 -1.0 1.3 3.1 2.1 2.3 2.5
Weight 0.3 1.4 3.5 1.2 0.8 1.6 -0.7 1.9 0.5 1.1 1.2 0.8
Impedance of arm (right) 13.7 63.8 81.2 -7.0 -8.5 -8.4 7.1 -6.0 -7.6 -9.0 -8.7 -8.9
Arm fat percentage (right) 0.2 0.9 2.2 -0.3 -1.4 -0.3 0.9 0.7 -0.8 -1.1 -0.9 -1.5
Trunk fat-free mass 1.4 7.8 9.9 2.8 3.0 2.6 -3.1 2.3 1.7 3.1 3.1 3.1
Hip circumference 0.2 0.9 1.7 1.3 0.7 1.2 0.5 1.2 0.4 1.0 1.0 0.6
Time employed in main current job 0.5 0.6 3.2 -1.8 -0.6 0.2 -0.6 -0.5 0.5 -0.6 -0.4 -0.4
Alcohol intake versus 10 years previously 0.2 0.4 1.4 -0.9 0.3 0.4 -0.8 0.2 1.2 0.1 0.5 0.1
Father’s age at death 0.3 0.4 2.2 1.5 0.5 0.3 -0.4 -0.1 -0.1 0.6 0.5 0.5
Worrier / anxious feelings 3.8 7.2 9.9 3.2 2.7 2.7 -2.4 1.5 3.1 2.6 2.7 3.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 0.0 -0.8 0.4 0.1 -1.1 0.6 -0.1 -0.4 -0.2
Falls in the last year 0.1 0.1 0.5 0.3 0.0 0.0 -0.5 -0.3 0.7 -0.1 -0.3 -0.2
Hair/balding pattern: Pattern 3 0.5 0.8 2.5 -0.7 0.6 0.9 -0.4 1.6 1.1 0.8 0.6 1.1
Number of live births 2.1 3.0 4.6 -2.1 -1.8 -1.3 1.6 -1.9 -1.5 -1.7 -1.6 -1.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.8 1.4 1.4 0.6 -0.1 0.0 -0.5 1.4 1.4 1.7
Pulse rate 5.9 9.9 16.3 -2.4 -2.9 -4.0 2.9 -2.2 -4.0 -3.0 -3.3 -3.1
Happiness 2.8 3.4 8.8 3.0 1.7 1.8 -0.5 1.7 1.1 2.0 2.0 1.8
Noisy workplace 1.0 1.2 3.0 -1.7 -1.1 -0.9 0.2 -1.3 -0.4 -1.3 -0.9 -1.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 1.1 0.4 -0.3 1.1 0.3 -0.9 0.5 0.0 0.5
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.6 1.6 1.3 0.6 -1.4 0.8 1.0 0.7 0.9 1.0
Mouth/teeth dental problems: Dentures 0.1 0.1 0.8 -0.9 0.2 -0.3 0.4 -0.2 -0.1 -0.1 0.0 -0.1
Asthma 3.8 7.5 13.8 -3.7 -2.9 -2.9 1.5 -2.1 -1.8 -3.2 -3.2 -2.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.4 1.1 0.5 -0.2 -1.2 0.1 0.1 0.1 0.0 0.5
Medication: Cholesterol lowering 0.2 0.4 0.8 0.5 0.5 0.9 -0.2 0.7 0.6 0.6 0.7 0.6
Depression (self-reported) 0.3 0.4 2.7 0.6 0.1 0.4 1.6 -0.2 0.1 0.1 0.0 0.2
Medication: Lansoprazole 2.5 2.9 4.1 1.6 2.0 1.3 -1.6 1.4 1.4 2.0 1.8 2.0
Prospective memory result 3.2 3.9 6.5 0.5 1.8 2.1 -2.5 2.0 2.3 2.0 2.0 1.8
Lung cancer (father) 0.3 0.4 0.7 0.7 0.8 0.0 0.0 0.6 -0.7 0.8 0.6 0.6
Illnesses of mother 0.1 0.2 0.6 0.1 -0.4 0.4 0.8 -0.2 -0.6 -0.1 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.0 1.7 1.1 0.4 0.2 -0.2 -0.5 1.1 1.0 1.3
Pulse wave Arterial Stiffness index 0.5 0.6 2.3 -0.0 -0.2 0.7 1.1 1.2 1.5 -0.1 0.0 -0.0
Impedance of arm (left) 11.9 55.0 67.4 -6.8 -7.8 -7.6 6.6 -6.0 -7.2 -8.2 -8.0 -8.2
Arm fat mass (right) 0.2 0.8 2.6 0.8 0.3 1.4 -0.6 1.6 0.4 0.6 0.8 0.2
Trunk predicted mass 1.4 7.7 9.7 2.9 3.0 2.6 -3.0 2.3 1.6 3.1 3.0 3.1
Standing height 1.1 10.5 21.5 -2.7 -2.9 -3.6 2.6 -2.6 -4.6 -3.2 -3.2 -3.1
Length of working week for main job 0.5 0.6 1.4 -0.1 -1.1 -0.6 0.3 0.0 -0.3 -1.2 -0.9 -1.1
Exposure to tobacco smoke at home 1.1 1.3 3.2 -1.0 -1.0 -1.8 -0.1 -0.7 -1.0 -1.3 -1.4 -1.0
Breastfed as a baby 0.5 0.6 3.1 -0.1 0.1 1.1 0.1 1.8 -0.2 0.8 0.3 0.4
Tense / ‘highly strung’ 0.2 0.3 1.5 0.3 -0.2 0.6 0.6 -0.2 1.2 -0.1 -0.0 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.9 0.1 -0.8 0.5 0.9 -0.1 -0.9 -0.4 -0.6 -0.4
Hair/balding pattern: Pattern 4 2.2 5.4 10.3 3.2 2.4 2.2 -1.1 1.7 2.7 2.2 2.5 2.3
Birth weight of first child 0.2 0.3 1.6 0.7 0.2 -0.0 0.7 1.3 -0.1 0.2 0.2 0.1
Peak expiratory flow (PEF) 1.9 4.4 6.8 2.0 2.3 2.4 -1.1 1.5 0.9 2.5 2.6 2.6
Pulse wave reflection index 1.0 1.3 4.1 -0.2 0.3 2.0 -0.7 1.0 2.0 0.7 0.9 0.7
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.0 1.0 1.0 1.7 0.0 0.9 1.2 1.1 1.3 1.0
Loud music exposure frequency 0.8 0.8 2.3 -0.7 -0.9 -0.9 -0.3 -0.6 -1.5 -1.0 -0.7 -1.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.3 1.2 0.7 0.1 0.3 0.5 -0.1 1.1 0.5 0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.8 0.9 0.0 0.4 0.6 0.1 0.1 0.0 -0.0 -0.0
Blood clot in the leg (DVT) 0.3 0.4 2.5 0.1 -0.2 -0.3 1.6 0.2 0.4 -0.3 -0.3 -0.3
Medication: Paracetamol 0.2 0.4 1.4 -0.7 0.0 1.0 -0.2 -0.2 1.2 0.6 0.4 0.2
Headache pain in last month 0.4 0.7 4.7 -0.7 -0.1 0.4 -0.9 -0.1 2.2 -0.0 -0.0 0.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.1 -0.5 -0.6 -1.0 0.6 -0.1 -1.4 -0.6 -0.8 -0.5
Glaucoma (self-reported) 0.3 0.3 1.7 1.3 0.4 0.2 -0.4 -0.6 -0.4 0.2 0.4 0.4
Gout (self-reported) 1.4 1.9 5.4 0.2 -1.1 -1.6 2.3 0.8 -2.0 -1.1 -1.1 -1.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 0.3 0.6 0.6 -0.3 0.3 0.6 0.3 0.7 0.5
Medication: Amlodipine 1.4 2.0 3.6 1.3 1.9 1.1 -0.9 0.7 1.5 1.6 1.7 1.4
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.3 -1.8 -1.3 -1.3 0.4 -0.9 -0.9 -1.4 -1.4 -1.1
Birth weight 2.0 4.3 8.7 -0.9 -1.9 -2.6 1.4 -2.0 -3.0 -2.1 -2.2 -2.0
Chronic bronchitis/emphysema (mother) 1.8 2.1 4.5 -1.1 -1.7 -1.3 0.7 -1.4 -0.0 -2.1 -1.8 -1.7
High blood pressure (siblings) 0.7 1.0 2.0 -1.4 -0.8 -1.4 0.8 -0.8 -0.2 -0.9 -1.0 -1.1
Forced vital capacity (FVC), Best measure 0.8 2.8 5.7 0.2 -1.1 -2.1 2.2 -2.0 -2.4 -1.4 -1.5 -1.0
Body fat percentage 0.3 1.0 2.5 -0.8 -1.5 -0.1 0.9 0.5 -0.8 -1.1 -0.9 -1.6
Leg fat percentage (right) 0.6 2.1 5.2 1.2 0.8 2.1 -1.1 2.3 1.3 1.3 1.4 0.9
Arm fat-free mass (right) 2.2 11.1 14.3 2.9 3.5 3.6 -3.4 2.6 2.6 3.8 3.7 3.6
Exposure to tobacco smoke outside home 0.5 0.6 2.8 0.2 0.1 -0.0 -1.4 -0.7 1.7 -0.0 0.0 0.2
Comparative body size at age 10 0.7 2.0 4.4 2.1 1.3 1.4 -0.9 1.3 -0.5 1.8 1.4 1.4
Number of full brothers 2.4 3.0 8.6 0.4 1.6 2.1 -0.6 2.9 1.9 1.3 1.8 1.6
Worry too long after embarrassment 2.4 4.0 10.0 3.2 1.9 1.8 -1.7 1.0 2.0 1.8 1.9 2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 3.1 -1.3 -1.6 -0.7 1.8 -1.3 -1.3 -1.6 -1.4 -1.3
Wheeze or whistling in the chest in last year 1.8 3.2 10.0 -3.2 -2.0 -1.3 0.1 -1.6 -0.7 -2.0 -1.9 -1.7
Number of children fathered 0.7 0.8 1.7 0.0 1.2 0.7 -0.1 1.1 0.5 1.3 1.2 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 0.7 -0.1 -1.2 -0.2 -0.0 -1.3 -0.7 -0.6 -0.3
Age at first live birth 0.5 0.8 2.5 0.6 -0.2 -1.3 1.0 -1.0 -1.6 -0.6 -0.4 -0.4
Pulse wave peak to peak time 0.6 0.7 3.0 -0.1 0.1 -0.8 -1.0 -1.2 -1.7 -0.1 -0.2 -0.1
Health satisfaction 0.2 0.3 1.6 0.6 0.1 0.7 0.2 0.5 1.3 0.2 0.3 0.2
Shortness of breath walking on level ground 0.3 0.4 1.2 -0.4 -0.7 -0.5 0.4 -0.2 -0.1 -0.8 -0.7 -1.1
Qualifications: College or University degree 0.2 0.6 3.0 0.7 -0.2 -0.9 1.7 0.7 -0.2 -0.5 -0.5 -0.2
Eye problems/disorders: None of the above 0.5 0.5 1.2 -1.1 -0.8 -0.6 -0.3 -0.7 -0.8 -0.6 -0.6 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.1 -0.4 -0.5 0.5 -0.2 -0.2 -0.6 -0.6 -0.6
Emphysema/chronic bronchitis 0.5 0.6 2.0 -1.4 -0.8 -0.3 -0.7 -0.1 0.2 -0.9 -1.0 -0.4
Medication for pain relief, constipation, heartburn 2.2 3.7 6.4 -0.8 -1.7 -2.5 2.0 -1.2 -2.5 -2.1 -1.9 -2.0
Neck or shoulder pain in last month 0.2 0.3 0.8 -0.9 -0.5 0.4 0.5 0.4 0.9 -0.3 -0.2 -0.4
Medication: Blood pressure 0.2 0.3 1.1 0.3 0.2 1.0 -0.4 -0.5 1.0 0.3 0.5 0.1
Angina (self-reported) 1.1 1.5 2.4 0.4 1.2 1.5 -1.0 0.2 1.4 1.4 1.3 1.5
Migraine (self-reported) 3.2 4.0 9.2 -3.0 -1.7 -2.2 0.4 -2.2 -1.7 -1.8 -2.0 -2.0
Medication: Ibuprofen 0.1 0.2 0.6 0.6 0.0 0.0 -0.8 0.1 0.6 -0.3 -0.3 0.1
Medication: Allopurinol 2.0 2.7 5.5 -0.4 -1.7 -1.6 2.3 -0.3 -2.1 -1.7 -1.6 -1.7
Medication: Omeprazole 0.1 0.2 0.5 0.3 0.2 0.7 0.2 0.4 0.6 0.2 0.2 0.0
Medication: Seretide 50 evohaler 5.5 6.3 12.0 -3.5 -2.6 -2.8 -0.3 -1.7 -2.0 -3.0 -2.6 -2.7
Mean time to correctly identify matches 1.0 2.0 3.3 -1.3 -1.5 -1.8 0.4 -0.4 -1.5 -1.5 -1.7 -1.7
Heart disease (mother) 1.1 1.3 4.8 -2.2 -1.3 -0.7 0.7 -0.1 -0.7 -1.1 -1.1 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.4 0.7 -0.2 -0.4 0.4 0.3 0.5 0.2 0.5
Whole body fat mass 0.1 0.2 0.8 -0.1 -0.6 0.7 0.2 0.9 -0.2 -0.1 0.0 -0.6
Leg fat mass (right) 0.4 1.7 4.2 1.2 0.7 2.1 -0.8 1.9 1.0 1.3 1.3 0.8
Arm predicted mass (right) 2.3 12.0 15.1 3.2 3.6 3.8 -3.5 2.8 2.6 3.9 3.8 3.8
Pulse rate, automated reading 7.2 23.2 29.6 -4.3 -5.1 -5.4 3.6 -4.4 -4.2 -5.4 -5.4 -5.1
Alcohol intake frequency. 0.6 1.4 4.8 -1.2 0.8 1.0 -2.2 0.1 1.6 0.6 0.9 0.8
Comparative height size at age 10 0.1 0.6 2.2 -0.3 -0.5 -1.0 0.5 -0.7 -1.5 -0.6 -0.6 -0.8
Number of full sisters 1.6 2.0 3.1 -1.3 -1.8 -0.9 1.5 -1.1 -0.7 -1.6 -1.6 -1.8
Suffer from ‘nerves’ 0.9 1.5 3.2 1.8 1.1 1.3 0.4 1.0 1.7 1.0 1.0 1.3
Overall health rating 0.5 1.1 2.3 -1.4 -1.4 -0.2 0.2 -1.5 0.2 -1.0 -1.0 -1.1
Chest pain or discomfort 0.9 1.3 5.2 -0.1 0.7 1.5 -0.7 0.3 2.3 0.8 1.0 1.1
Had major operations 0.2 0.3 1.5 -0.4 -0.1 0.2 1.2 0.4 0.8 -0.0 0.2 -0.1
Age at last live birth 4.3 6.2 11.3 -0.9 -2.0 -3.4 1.9 -2.9 -3.2 -2.5 -2.3 -2.4
Family relationship satisfaction 1.9 2.3 4.0 2.0 1.5 1.6 -0.9 1.1 1.5 1.7 1.7 1.4
Leg pain on walking 0.8 1.0 3.1 -0.2 -0.9 -1.1 1.8 0.2 -0.7 -0.9 -0.9 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.2 1.0 1.1 1.2 -0.3 1.1 0.3 1.2 1.5 1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.2 -0.5 0.3 0.6 -0.6 1.1 0.6 0.1 0.5 0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.3 0.5 0.4 0.7 -0.5 0.3 0.4 0.5 0.6
Medication: Aspirin 1.1 1.4 2.2 0.5 1.4 1.4 -1.1 1.0 0.7 1.5 1.4 1.4
Supplements: Vitamin C 0.3 0.4 1.0 0.4 0.6 0.5 -0.9 -0.1 1.0 0.5 0.5 0.6
Knee pain experienced in last month 0.2 0.3 0.7 -0.6 -0.8 -0.1 0.8 0.4 -0.7 -0.2 -0.4 -0.6
Hypertension (Self-reported) 2.1 5.8 8.9 2.2 2.3 2.6 -2.2 1.9 3.0 2.5 2.6 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.3 4.6 1.4 1.5 1.6 -2.1 0.2 1.1 1.9 1.6 1.6
Illnesses of father: Heart disease 0.1 0.2 0.7 -0.8 -0.3 -0.3 -0.1 0.0 0.3 -0.6 -0.3 -0.3
Illnesses of siblings: Diabetes 0.3 0.3 1.8 0.4 0.4 0.2 -1.4 0.1 0.5 0.3 0.4 0.4
Smoking status: Previous 0.7 1.0 1.5 -0.7 -1.0 -1.1 0.6 -0.6 -1.2 -1.2 -1.2 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.4 1.5 0.7 0.2 -0.3 0.6 0.5 0.7 0.6 0.8
Whole body fat-free mass 0.9 5.2 6.3 2.3 2.4 2.3 -2.4 1.9 1.4 2.5 2.5 2.5
Leg fat-free mass (right) 0.2 0.9 1.4 1.1 0.9 1.2 -0.7 1.2 0.5 1.0 1.1 0.8
Arm fat percentage (left) 0.2 0.7 1.8 -0.3 -1.2 -0.0 0.8 0.6 -0.8 -0.9 -0.8 -1.4
Average weekly red wine intake 0.2 0.4 1.6 0.2 0.3 -0.5 1.0 0.5 -1.3 0.2 0.0 0.2
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.3 -0.1 -0.4 -0.7 0.2 0.3 -1.1 -0.7 -0.5 -0.5
Mood swings 1.1 1.9 5.8 1.3 1.2 1.5 -0.9 -0.1 2.4 1.1 1.5 1.4
Loneliness, isolation 2.3 3.2 9.8 -0.8 0.6 2.6 -2.7 0.5 3.1 1.1 1.3 1.0
Long-standing illness, disability or infirmity 2.5 3.8 12.2 -3.5 -2.3 -1.1 1.0 -1.2 -1.1 -1.9 -1.9 -2.3
Ever had bowel cancer screening 0.6 0.7 1.8 -1.3 -0.3 -1.3 0.1 -0.8 -1.0 -0.7 -0.7 -0.5
Diabetes diagnosed by doctor 0.2 0.3 0.9 0.5 0.5 -0.3 -0.9 0.6 -0.5 0.7 0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.5 0.4 0.2 1.2 -0.4 0.3 1.2 0.7 0.6 0.3
Friendships satisfaction 5.1 6.3 10.8 3.3 2.8 2.5 -1.5 1.6 2.0 2.8 2.8 2.8
Qualifications: nursing, teaching 0.2 0.3 1.5 0.2 0.5 -0.1 -0.6 1.2 -0.3 0.5 0.4 0.4
Commuting to job workplace: Walk 1.6 1.7 2.9 1.5 1.5 1.1 -1.0 0.5 1.4 1.4 1.2 1.7
Eye problems/disorders: Cataract 0.3 0.4 1.8 0.1 0.4 0.3 0.7 0.6 1.4 0.4 0.3 0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.5 -0.8 -0.8 -0.1 1.2 -0.4 0.1 -0.5 -0.7 -0.6
Medication for cholesterol 1.4 2.1 4.7 -0.8 -1.5 -1.4 1.3 -2.2 -0.9 -1.7 -1.5 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 -0.7 -0.0 0.9 -0.1 0.1 -0.5 0.5 0.4 0.0
Back pain experienced in last month 0.4 0.5 2.1 -0.4 0.3 1.4 -0.6 -0.1 0.9 0.6 0.7 0.5
Mineral and other dietary supplements 0.3 0.4 1.5 0.0 0.4 0.8 -0.2 -0.4 1.2 0.5 0.6 0.6
Breast cancer (self-reported) 1.1 1.3 3.5 1.1 1.4 0.9 0.1 1.9 0.6 1.1 1.3 1.2
Asthma (self-reported) 4.0 7.9 13.9 -3.7 -3.0 -2.9 1.8 -2.1 -2.0 -3.2 -3.2 -2.8
Osteoporosis (self-reported) 1.2 1.4 4.7 -2.2 -0.6 -1.3 -0.7 -1.4 -0.5 -1.2 -1.1 -0.8
Osteoarthritis (self-reported) 1.5 2.0 4.8 -2.2 -1.7 -0.6 0.4 -1.6 -1.0 -1.2 -1.2 -1.7
Medication: Aspirin 0.7 0.9 1.4 0.3 1.1 1.2 -1.0 0.6 0.3 1.1 1.1 1.2
Medication: Gliclazide 0.7 0.8 1.1 1.0 1.1 0.6 -0.6 1.1 0.2 1.0 1.1 1.1
Illnesses of father: None of the above (group 1) 0.3 0.4 2.4 0.1 -0.4 -0.8 0.1 -0.1 -1.5 -0.4 -0.4 -0.4
Smoking status: Current 0.5 0.8 4.9 -2.2 -0.6 -0.5 0.1 -1.0 -0.2 -0.6 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 4.6 2.1 1.7 1.8 -0.4 1.0 1.1 2.0 2.0 1.8
Whole body water mass 0.9 5.2 6.3 2.4 2.4 2.2 -2.4 2.0 1.5 2.5 2.5 2.5
Leg predicted mass (right) 0.2 0.9 1.4 1.1 0.8 1.2 -0.8 1.2 0.5 1.0 1.1 0.8
Arm fat mass (left) 0.2 0.8 2.1 0.8 0.4 1.4 -0.7 1.3 0.6 0.7 0.9 0.4
Number of self-reported non-cancer illnesses 1.0 1.7 2.6 -1.6 -1.6 -1.1 0.8 -1.3 -0.6 -1.3 -1.4 -1.6
Average weekly champagne plus white wine intake 0.8 1.1 3.6 0.2 -1.0 -0.9 0.4 -1.3 -1.9 -0.9 -1.0 -1.0
Miserableness 2.3 4.0 9.5 3.1 1.7 2.4 -0.5 1.1 1.9 2.2 2.1 1.9
Guilty feelings 3.5 5.2 9.5 3.1 2.2 1.9 -1.5 1.9 2.3 2.2 2.4 2.6
Wears glasses or contact lenses 2.1 2.5 4.9 -0.7 -1.8 -1.3 2.2 0.2 -0.5 -2.0 -1.9 -2.0
Ever taken oral contraceptive pill 1.1 1.3 2.2 -0.4 -1.3 -1.2 0.7 -1.2 -0.8 -1.2 -1.4 -1.5
Hearing aid user 0.9 1.0 2.2 -1.2 -1.4 -0.3 1.5 -0.6 -0.4 -0.9 -1.0 -1.2
Mother’s age at death 0.6 0.8 2.2 1.5 0.5 -0.4 1.2 1.5 -0.3 0.7 0.2 0.5
Financial situation satisfaction 0.1 0.2 1.1 0.1 -0.2 -0.0 -0.3 -0.4 1.1 -0.1 0.0 -0.1
Tinnitus: Yes, now most or all of the time 2.4 2.7 4.3 -0.6 -1.4 -1.7 2.1 -1.7 -2.0 -1.7 -1.7 -1.7
Commuting to job workplace: Public transport 0.2 0.2 0.8 0.6 -0.1 -0.5 0.9 -0.5 -0.3 0.1 -0.3 -0.2
Eye problems/disorders: Glaucoma 0.8 0.9 4.0 2.0 0.9 0.7 -0.3 0.7 0.3 0.8 1.0 0.8
Medication: Blood pressure 1.9 3.7 6.1 1.4 2.1 1.7 -1.6 2.5 1.4 2.4 2.0 2.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.8 -1.3 -1.2 -0.5 0.3 -0.0 -0.5 -1.2 -1.1 -1.1
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.2 0.1 -0.4 -0.2 0.2 0.6 -1.1 -0.2 -0.3 -0.4
High cholesterol (Self-reported) 1.5 2.6 5.4 1.3 1.9 1.4 -1.3 1.0 0.7 2.3 2.0 1.9
Medication: Bendroflumethiazide 0.2 0.2 1.6 -0.1 -0.3 -0.1 0.1 -1.3 -0.2 -0.4 -0.4 -0.3
Medication: Paracetamol 0.2 0.2 0.6 -0.8 -0.6 0.4 0.6 -0.4 0.2 -0.2 -0.3 -0.5
Medication: Lisinopril 0.1 0.1 0.3 0.1 -0.3 -0.3 0.5 -0.6 -0.0 -0.2 -0.2 -0.5
Medication: Atorvastatin 2.8 3.5 6.4 1.7 2.0 2.2 -0.9 0.8 1.6 2.5 2.2 2.1
Illnesses of father: High blood pressure 0.3 0.4 2.3 0.4 0.2 0.6 0.1 -0.4 1.5 0.2 0.3 0.2
Alcohol drinker status: Never 0.3 0.4 1.8 -1.3 0.5 -0.0 -0.9 -0.1 0.4 0.3 0.3 0.4
Ever smoked 0.4 0.7 1.2 -0.7 -0.8 -1.0 0.6 0.3 -1.1 -0.8 -0.9 -1.0
Basal metabolic rate 0.7 3.8 4.8 2.0 2.0 2.1 -2.0 1.8 1.2 2.1 2.2 2.0
Leg fat percentage (left) 1.1 3.9 8.6 1.4 1.3 2.9 -1.5 2.8 2.0 1.8 2.0 1.4
Arm fat-free mass (left) 2.0 10.0 12.2 2.9 3.2 3.3 -3.3 2.8 2.4 3.5 3.5 3.4
Number of operations (self-reported) 0.8 1.3 3.0 0.4 1.0 1.7 0.3 0.6 1.5 1.2 1.4 1.0
Average weekly beer plus cider intake 0.4 0.5 1.3 -0.6 -0.6 -1.1 -0.2 -1.0 0.6 -0.7 -0.7 -0.6
Irritability 4.0 6.7 13.7 2.2 2.5 3.0 -1.7 1.1 3.7 2.8 2.7 2.7
Risk taking 0.4 0.6 1.2 -1.0 -0.9 -0.6 0.1 -0.5 0.1 -0.9 -0.7 -1.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.3 0.5 1.1 0.1 -0.6 0.5 0.1 1.0 1.0 0.9
Fractured/broken bones in last 5 years 2.6 3.4 6.6 -2.6 -1.2 -2.3 0.9 -1.5 -2.5 -1.5 -1.8 -1.6
Age started oral contraceptive pill 3.1 3.9 5.7 -2.4 -1.8 -2.0 2.3 -0.9 -1.9 -1.9 -2.1 -1.9
Diastolic blood pressure, automated reading 4.8 14.8 22.2 4.0 4.0 3.7 -4.7 1.6 3.3 4.1 4.1 4.2
Ever depressed for a whole week 2.2 2.7 6.1 -0.7 -1.7 -1.2 2.5 -0.6 -2.1 -1.7 -1.6 -1.8
Unable to work because of sickness or disability 0.2 0.2 0.5 -0.6 -0.5 -0.6 -0.1 0.0 0.3 -0.5 -0.6 -0.7
Commuting to job workplace: Cycle 0.3 0.4 1.5 -0.7 -0.7 -0.2 1.2 0.1 -0.2 -0.5 -0.5 -0.6
Myopia 0.7 1.0 1.5 0.7 1.1 0.8 -1.1 0.6 1.1 1.2 1.2 1.2
Vascular/heart problems diagnosed by doctor 2.7 7.2 9.1 -2.4 -2.7 -2.8 2.7 -2.1 -3.0 -2.8 -3.0 -2.6
Cholesterol lowering medication 0.8 1.2 3.0 0.4 1.1 0.8 -0.7 1.4 -0.2 1.7 1.3 1.3
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.4 0.9 0.7 1.1 -0.5 0.9 1.2 0.8 0.7 0.6
Pain experienced in last month 0.3 0.5 1.5 1.2 1.0 -0.3 -0.6 -0.1 0.1 0.6 0.6 0.6
Supplements: Calcium 1.0 1.1 1.7 -1.0 -1.0 -1.3 -0.0 -1.1 -0.8 -1.1 -1.3 -1.3
Basal cell carcinoma (self-reported) 0.2 0.2 1.2 -0.2 -0.3 0.0 0.8 0.3 -1.1 -0.2 -0.1 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 -1.1 -0.7 -0.5 -0.5 -0.4 -0.6 -0.5 -0.6 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 2.1 0.1 -0.2 -0.3 1.5 0.3 0.3 -0.3 -0.3 -0.3
Heart disease (siblings) 0.7 0.8 4.2 -2.0 -0.5 -0.2 -1.1 -0.9 0.4 -0.7 -0.5 -0.5
Alcohol drinker status: Previous 0.6 0.7 1.2 -0.4 -0.9 -0.6 1.0 -0.3 -0.8 -1.0 -0.9 -1.1
Pack years of smoking 2.4 3.5 4.9 -2.2 -2.2 -1.3 1.3 -1.8 -1.5 -2.1 -2.1 -2.2
Impedance of whole body 5.9 29.9 36.0 -5.1 -5.7 -5.5 4.9 -4.5 -5.4 -6.0 -5.9 -6.0
Leg fat mass (left) 0.7 2.7 6.8 1.3 1.0 2.6 -1.1 2.3 1.4 1.6 1.7 1.2
Arm predicted mass (left) 2.1 10.4 12.6 3.0 3.3 3.3 -3.4 2.9 2.4 3.5 3.5 3.5