Hub : Genes

GAB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0990	0.0510	6.2e-03	0.016	NA	0.024	NA	0.024	4.5e-02	NA	1.7e-02	NA	1.7e-02
2	GTEx	Artery Tibial	0.0638	0.0326	8.9e-03	0.004	NA	-0.003	NA	0.014	1.5e-01	NA	7.0e-01	NA	2.4e-02
3	GTEx	Esophagus Muscularis	0.0540	0.0280	6.1e-03	0.041	NA	0.034	NA	0.040	1.5e-03	NA	4.0e-03	NA	1.8e-03
4	GTEx	Liver	0.1680	0.0770	5.7e-03	-0.006	NA	-0.007	NA	-0.008	5.1e-01	NA	5.7e-01	NA	6.5e-01
5	GTEx	Skin Sun Exposed Lower leg	0.0590	0.0290	1.1e-03	0.013	NA	0.028	NA	0.014	2.9e-02	NA	2.2e-03	NA	2.3e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0487	0.0206	2.0e-04	0.001	0.021	0.012	0.021	0.003	2.3e-01	8.0e-04	8.3e-03	0.00092	1.2e-01
7	TCGA	Glioblastoma Multiforme	0.1010	0.0720	4.1e-03	0.071	0.094	0.091	NA	0.053	3.5e-03	8.8e-04	1.0e-03	NA	1.0e-02
8	TCGA	Prostate Adenocarcinoma	0.0598	0.0329	2.4e-08	0.055	0.070	0.055	NA	0.067	1.8e-06	7.8e-08	1.8e-06	NA	1.7e-07
9	TCGA	Stomach Adenocarcinoma	0.0360	0.0240	1.8e-03	0.038	0.035	0.027	NA	0.032	8.5e-04	1.4e-03	4.4e-03	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.6	0.9	2.9	1.0	0.8	1.0	0.0	0.9	1.7	0.3	0.7	0.9
Bipolar Disorder or Schizophrenia	2.0	4.9	9.7	2.1	2.4	1.8	-2.1	1.5	3.1	1.8	2.1	2.6
Depressed Affect (Nagel 2018)	3.1	6.5	15.1	2.0	2.2	3.2	-1.4	1.3	3.9	2.6	2.8	2.5
Depression (Nagel 2018)	2.2	3.3	9.3	1.0	1.3	2.5	-1.4	0.9	3.0	1.7	1.8	1.7
Intelligence (Savage-Jansen 2018)	0.8	2.5	12.8	-0.0	-1.2	-1.4	3.6	-0.1	-1.7	-0.8	-1.2	-1.4
Neuroticism (Nagel 2018)	6.6	15.5	25.5	4.4	3.8	4.1	-3.0	2.5	5.0	3.8	4.0	4.1
Schizophrenia (2018)	2.3	4.7	7.6	1.9	2.4	1.6	-2.8	0.9	2.6	2.0	2.1	2.6
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	-0.4	-0.8	-1.3	0.6	-1.6	-0.6	-0.8	-0.9	-1.0
Worry (Nagel 2018)	3.3	7.0	12.2	3.5	2.6	2.8	-1.4	1.7	3.3	2.4	2.5	2.9
Alzheimer’s Disease (in mother)	0.2	0.3	1.5	0.4	-0.2	-0.4	-1.2	-0.4	-0.6	0.1	0.1	-0.2
Alzheimer’s Disease (in father)	0.5	0.5	2.8	-0.7	0.2	0.4	-1.0	0.1	1.7	0.1	0.2	0.1
Alzheimer’s Disease (including proxy)	1.1	1.6	3.9	1.4	0.8	1.3	-2.0	0.6	1.2	1.3	1.4	1.0
Crohns Disease (2017)	0.6	1.2	1.8	-0.8	-1.2	-1.0	1.3	-1.3	-0.7	-1.0	-1.3	-1.1
Irritable Bowel Disease (IBD)	2.9	6.9	8.4	-2.3	-2.8	-2.6	2.1	-2.7	-2.7	-2.7	-2.9	-2.7
Ulcerative Colitis (UC)	5.2	9.8	11.6	-2.6	-3.3	-3.2	2.2	-3.1	-3.4	-3.4	-3.4	-3.3
Major Depression (MDD)	0.9	1.0	2.8	1.1	0.8	0.8	-0.1	1.4	1.7	0.7	0.8	0.8
Reaction Time	1.0	1.8	3.3	-0.5	-1.3	-1.8	0.7	-1.3	-1.8	-1.3	-1.4	-1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	5.0	1.0	-0.0	-0.2	2.2	1.3	0.3	0.3	-0.1	0.0
Breast Cancer	1.1	2.6	5.8	-0.9	-1.2	-1.9	2.4	-1.8	-1.7	-1.3	-1.5	-1.3
Ovarian Cancer	0.6	0.8	1.2	0.5	0.8	1.0	-1.1	1.1	0.3	1.0	1.0	0.9
Prostate Cancer	0.3	0.5	1.6	-1.3	-0.4	-0.7	-0.8	-0.7	-0.2	-0.2	-0.6	-0.6
Age at First Birth	0.2	0.3	1.4	0.8	-0.0	0.7	0.3	1.2	0.5	0.1	0.3	0.3
Bipolar Disorder (2011)	0.2	0.2	0.8	0.2	0.2	0.2	0.4	0.3	0.9	0.1	-0.0	0.4
Body Mass Index (BMI) (2010)	6.0	8.3	12.2	3.3	3.5	2.3	-1.7	2.5	2.2	3.1	3.2	3.5
Coronary Artery Disease (CAD)	2.9	3.4	6.1	1.0	1.6	2.2	-1.6	1.5	2.5	1.9	2.0	2.0
Crohns Disease (2012)	0.5	0.8	1.6	-0.5	-0.9	-0.7	1.3	-1.2	-0.9	-0.7	-0.8	-0.9
Mean Putamen Volume	0.4	0.4	1.3	0.5	-0.2	-0.5	1.2	-1.0	-0.9	-0.3	-0.2	-0.3
Fasting Glucose	0.6	0.7	2.2	0.5	-1.2	-0.2	1.5	0.7	-1.1	-0.5	-0.5	-0.4
HbA1C	4.4	4.9	7.6	2.6	2.0	2.2	-1.3	1.2	2.1	2.8	2.4	2.7
HDL Cholesterol	0.1	0.1	0.3	0.4	-0.3	0.1	-0.3	-0.2	0.6	-0.6	-0.2	-0.4
LDL Cholesterol	6.7	10.6	15.7	3.3	3.8	2.8	-2.5	2.6	2.4	3.8	3.7	4.0
Lupus	0.4	0.5	1.0	-0.2	-1.0	-0.1	0.8	-1.0	0.2	-1.0	-0.9	-0.7
Neuroticism (2016)	1.9	2.7	3.8	1.5	1.3	1.3	-1.5	2.0	2.0	1.8	1.6	1.7
Primary Biliary Cirrhosis	0.3	0.4	3.3	0.3	0.0	0.1	-0.2	-1.8	0.7	-0.2	-0.2	0.1
Rheumatoid Arthritis	1.9	2.6	6.3	-0.8	-1.4	-1.8	1.1	-2.5	-1.3	-1.8	-1.7	-1.6
Schizophrenia (2014)	1.2	2.6	5.7	1.6	1.9	0.9	-1.8	0.3	2.4	1.3	1.5	1.8
Triglycerides	2.9	4.7	8.2	1.8	2.5	2.1	-1.1	2.1	1.3	2.9	2.6	2.4
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.5	-2.1	-1.8	-0.4	1.8	-2.1	-1.3	-1.3	-1.3	-1.5
Ulcerative Colitis	3.5	5.1	7.4	-1.8	-2.6	-2.1	1.5	-2.2	-2.7	-2.4	-2.3	-2.4
Blood Eosinophil Count	0.1	1.1	4.3	-2.1	-0.2	1.3	-0.9	1.1	1.1	0.2	0.3	-0.3
Blood Platelet Count	0.9	10.8	29.4	2.6	3.5	2.2	-3.3	1.6	5.4	3.0	3.0	3.5
Blood Red Count	1.6	15.3	23.2	-3.1	-4.0	-4.8	3.1	-3.1	-4.1	-4.0	-4.3	-4.2
Blood White Count	0.0	0.3	0.9	-0.3	-0.2	-0.8	-0.1	-0.9	0.6	-0.5	-0.6	-0.4
Heel T-Score	2.6	20.9	25.0	4.6	4.9	5.0	-3.2	3.8	4.8	4.7	5.0	4.8
BMI	3.0	17.3	21.1	4.2	3.9	4.6	-3.3	4.1	4.3	4.3	4.5	4.0
Height	1.1	21.3	33.6	-3.8	-4.3	-4.9	4.9	-3.5	-5.8	-4.6	-4.8	-4.4
Waist Hip Ratio (WHR)	0.7	3.4	7.7	-2.8	-1.7	-1.6	-0.9	-1.4	-1.9	-2.0	-1.9	-1.9
Systolic Blood Pressure	1.2	5.9	8.9	3.0	2.4	2.3	-2.6	0.9	2.4	2.5	2.5	2.6
Smoking Status	1.8	4.4	8.0	-2.8	-2.2	-2.0	1.0	-1.9	-1.5	-2.4	-2.2	-2.3
Allergy or Eczema	1.9	5.0	6.8	-2.5	-2.5	-2.3	1.6	-1.8	-1.3	-2.6	-2.5	-2.5
Cardiovascular Disease	3.6	11.9	16.1	2.6	3.2	3.9	-3.3	2.7	4.0	3.7	3.7	3.4
Hypothyroidism (self reported)	0.7	1.6	2.4	1.0	1.4	1.5	-0.7	1.0	1.2	1.2	1.5	1.3
Respiratory disease	2.6	5.9	11.5	-3.4	-2.4	-2.6	1.3	-1.5	-1.9	-2.8	-2.8	-2.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.8	0.8	0.5	-0.4	-1.3	0.6	-0.2	0.5	0.4	0.4
Lung FEV1/FVC ratio	9.8	49.5	66.2	4.7	7.4	8.0	-6.6	5.6	6.4	7.8	8.1	7.8
Lung FVC	0.4	2.0	4.2	-1.4	-1.1	-1.7	1.6	-2.1	-0.7	-1.3	-1.5	-1.0
Neuroticism	9.2	22.1	34.4	5.1	4.8	4.8	-2.9	3.5	5.9	4.8	4.8	5.2
Chronotype (morning person)	4.9	11.4	23.0	2.2	3.4	3.3	-3.0	3.4	4.8	3.2	3.3	3.4
Hair Pigment	13.9	397.4	484.0	18.3	21.5	20.6	-16.7	16.0	19.3	21.9	22.0	22.0
Tanning	2.6	31.6	40.7	-4.7	-6.2	-6.0	5.5	-3.2	-5.4	-6.2	-6.4	-6.3
Hand grip strength (left)	0.5	1.4	2.9	1.6	1.6	0.6	0.6	0.0	-1.0	1.2	1.4	1.7
Number of treatments/medications taken	0.1	0.1	0.3	-0.3	-0.4	0.3	-0.4	0.2	0.4	-0.3	-0.3	-0.6
Average weekly spirits intake	0.3	0.4	0.8	0.3	-0.4	-0.7	0.8	-0.4	-0.9	-0.5	-0.6	-0.6
Sensitivity / hurt feelings	7.5	12.8	15.5	3.9	3.6	3.6	-3.5	2.7	3.6	3.6	3.7	3.9
Frequency of depressed mood in last 2 weeks	2.4	3.4	8.1	0.9	1.4	2.5	-1.4	0.9	2.9	1.9	1.8	1.9
Hearing difficulty/problems: Yes	1.0	1.5	3.0	-1.2	-1.4	-0.9	1.7	-0.4	-0.7	-1.3	-1.3	-1.4
Relative age of first facial hair	1.8	3.7	5.1	-1.8	-2.0	-1.7	1.7	-1.6	-2.2	-2.3	-1.9	-2.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.6	-1.5	-1.3	-0.5	0.8	-1.6	-1.5	-1.2	-1.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	2.0	-1.4	0.2	0.2	-0.5	0.1	0.3	0.2	0.2	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.6	-0.2	-0.1	0.0	-0.4	-0.3	0.0	-0.1	-0.2
Systolic blood pressure, automated reading	1.1	3.2	4.7	2.2	1.9	1.6	-2.1	0.5	2.0	1.7	1.7	1.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.1	1.1	0.8	0.2	-0.6	1.0	0.7	0.7	0.6	0.7
Angina	0.9	1.2	2.1	0.2	1.1	1.5	-0.8	0.3	1.3	1.4	1.2	1.4
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	-0.6	-0.2	0.4	0.3	-0.4	-0.6	-0.6	-0.8
Vitamin and mineral supplements	0.5	0.7	1.5	0.6	0.7	1.2	-0.3	0.5	0.8	1.1	1.2	0.7
Supplements: Zinc	0.2	0.2	0.9	1.0	0.4	-0.2	-0.5	0.1	-0.6	0.1	0.2	0.4
Medication: Co-codamol	0.2	0.3	1.0	-1.0	-0.4	0.2	-0.6	-0.7	0.4	-0.3	-0.3	-0.2
Medication: Metformin	0.1	0.2	0.7	0.5	0.3	-0.4	-0.9	0.2	-0.6	0.3	0.3	0.3
Diabetes (father)	0.1	0.2	0.9	1.0	0.1	0.4	0.0	0.0	-0.3	0.5	0.2	0.1
Diabetes (mother)	0.2	0.2	0.6	-0.7	-0.5	-0.8	-0.3	-0.1	0.2	-0.4	-0.4	-0.6
Severe depression (siblings)	1.0	1.2	2.0	-1.4	-1.0	-1.3	0.2	-0.8	-1.1	-1.1	-1.2	-1.0
Pack years adult smoking proportion	1.8	2.7	4.2	-2.1	-2.0	-1.0	1.0	-1.5	-1.1	-1.8	-1.8	-2.0
Impedance of leg (right)	1.3	6.2	7.2	-2.7	-2.5	-2.6	1.8	-2.5	-2.7	-2.5	-2.6	-2.4
Leg fat-free mass (left)	0.1	0.4	0.8	0.9	0.4	0.7	-0.5	0.8	0.1	0.6	0.7	0.4
Trunk fat percentage	0.7	2.9	6.2	-1.6	-2.3	-1.0	1.5	-0.3	-1.5	-1.9	-1.7	-2.5
Hand grip strength (right)	0.6	1.5	3.0	1.7	1.5	1.1	0.5	-0.3	-0.5	1.4	1.4	1.7
Townsend deprivation index at recruitment	6.3	8.9	13.0	-3.5	-3.6	-2.8	2.5	-1.6	-1.7	-3.1	-3.4	-3.6
Current tobacco smoking	0.4	0.7	4.8	-2.2	-0.3	-0.2	-0.1	-0.9	-0.1	-0.4	-0.2	-0.3
Average weekly fortified wine intake	5.5	6.4	8.9	-2.5	-2.6	-2.8	1.5	-1.9	-3.0	-2.7	-3.0	-2.5
Maternal smoking around birth	0.9	1.3	6.1	-0.5	0.3	0.9	-2.0	-0.1	2.5	0.2	0.5	0.3
Fed-up feelings	1.5	2.6	5.2	1.1	1.5	2.1	-0.8	0.3	2.3	1.8	1.9	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	5.2	0.5	1.1	2.1	-1.7	0.3	2.3	1.5	1.6	1.6
Relative age voice broke	0.5	0.7	1.3	-0.7	-0.8	-0.7	1.0	-0.5	-1.1	-1.1	-0.7	-0.8
Taking other prescription medications	2.0	3.0	5.7	-2.0	-2.3	-1.1	1.0	-0.1	-1.4	-2.1	-1.9	-2.4
Age when periods started (menarche)	12.0	28.7	37.2	-6.1	-5.4	-5.1	3.8	-5.9	-5.4	-5.5	-5.4	-5.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.5	0.4	0.9	-0.6	0.5	0.5	0.6	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	7.6	2.4	1.8	1.9	-0.3	2.8	1.4	2.0	2.0	1.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.5	-0.9	0.6	0.0	-1.9	0.5	0.8	0.3	0.5	0.8
Qualifications: CSEs or equivalent	1.4	1.9	3.2	1.4	1.4	1.4	-1.8	0.2	0.7	1.6	1.6	1.5
Serious illness, injury or assault to yourself	0.7	0.8	2.8	-1.7	-1.0	-0.8	0.4	-0.3	-0.7	-0.7	-0.9	-0.9
High blood pressure	2.7	7.6	11.4	2.6	2.8	2.8	-2.5	2.0	3.4	2.9	3.0	2.6
Hayfever, allergic rhinitis or eczema	1.6	3.5	4.4	-1.9	-2.1	-2.1	1.4	-1.7	-1.2	-2.1	-2.0	-2.1
Multivitamins +/- minerals	0.2	0.3	0.7	-0.0	-0.5	-0.7	0.2	0.3	-0.7	-0.6	-0.8	-0.5
Stomach or abdominal pain in last month	0.7	0.9	2.9	0.8	0.8	1.2	-0.3	0.5	1.7	0.8	1.0	0.8
Supplements: Glucosamine	0.4	0.5	1.2	1.1	0.8	-0.1	-0.5	1.0	0.4	0.6	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.0	1.7	0.8	-0.0	1.0	0.6	-0.3	0.4	0.4	0.6
Medication: Atenolol	3.2	4.0	5.7	1.5	2.3	1.7	-2.3	0.3	1.8	2.4	2.2	2.4
Medication: Levothyroxine sodium	0.5	0.8	1.9	0.7	1.0	1.1	-0.9	0.5	1.4	0.6	0.9	0.8
Sitting height	0.4	2.7	5.2	-1.4	-1.2	-2.2	0.7	-2.0	-2.3	-1.5	-1.5	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	2.1	-0.8	-0.7	-0.1	1.4	-0.5	-0.2	-0.4	-0.6	-0.8
High blood pressure (mother)	1.5	2.1	4.5	1.2	1.8	0.3	-2.1	0.0	1.6	1.4	1.3	1.8
Body mass index (BMI)	1.9	8.3	13.2	2.7	2.4	3.6	-2.1	3.4	2.9	2.9	3.0	2.5
Impedance of leg (left)	0.7	3.4	6.1	-2.5	-1.9	-1.5	1.3	-1.8	-1.9	-1.9	-1.9	-1.8
Leg predicted mass (left)	0.1	0.4	0.9	0.9	0.4	0.7	-0.5	0.8	0.1	0.6	0.7	0.4
Trunk fat mass	0.2	0.9	2.2	-0.6	-1.3	-0.2	0.8	0.4	-1.0	-1.0	-0.8	-1.5
Waist circumference	0.1	0.3	1.6	0.3	0.0	0.8	-0.5	1.3	0.1	0.3	0.4	-0.0
Number of incorrect matches in round	1.0	1.6	3.9	1.5	1.3	0.7	-2.0	1.3	0.6	1.1	1.1	1.1
Past tobacco smoking	0.9	1.6	2.5	1.1	1.1	1.6	-0.9	0.5	1.6	1.3	1.4	1.4
Alcohol usually taken with meals	4.2	6.8	10.4	2.7	2.9	2.6	-2.0	2.1	1.6	3.0	2.7	3.2
Nervous feelings	0.3	0.5	3.3	0.9	0.2	-0.2	0.1	-1.8	0.1	-0.4	-0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.0	1.4	1.0	1.5	-0.7	0.1	2.0	1.0	1.1	1.2
Hearing difficulty/problems with background noise	0.1	0.2	0.8	-0.4	-0.0	-0.2	0.4	-0.9	0.5	-0.3	0.0	-0.0
Hair/balding pattern: Pattern 2	5.3	6.7	9.7	-1.8	-2.9	-2.5	1.8	-2.8	-2.6	-2.7	-2.8	-3.1
Had menopause	1.4	1.7	6.1	0.6	1.2	1.5	-0.4	2.5	1.1	1.3	1.2	1.1
Had other major operations	0.7	0.8	1.6	0.7	0.8	1.2	0.8	1.3	0.8	0.7	1.1	0.7
Forced vital capacity (FVC)	0.5	1.8	5.2	0.4	-0.6	-1.6	1.7	-1.8	-2.3	-0.7	-0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.6	8.6	2.9	2.3	2.5	-0.4	2.6	2.1	2.5	2.7	2.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	-0.8	-1.3	-1.0	0.2	-0.8	-0.9	-1.4	-1.2	-1.3
Qualifications: None of the above	0.3	0.7	1.9	-1.3	-0.4	0.3	-1.1	-1.4	0.7	-0.3	-0.3	-0.5
Financial difficulties in last 2 years	1.2	1.7	3.1	-0.4	-1.7	-1.3	0.5	-0.4	-1.3	-1.5	-1.8	-1.7
Mouth/teeth dental problems	0.4	0.6	2.0	1.0	0.7	0.1	-1.4	0.3	0.0	0.7	0.7	0.8
Heart attack	0.5	0.6	1.4	-1.2	-1.0	-0.6	-0.4	-0.6	-0.6	-0.7	-0.8	-0.8
Allergy	2.2	5.2	7.8	2.8	2.5	2.2	-1.7	1.8	1.2	2.6	2.5	2.5
Pain all over the body in last month	1.2	1.3	2.0	-1.0	-1.1	-1.2	0.2	-1.4	-1.1	-1.3	-1.2	-1.2
Diabetes (self-reported)	0.1	0.1	0.3	0.1	0.1	-0.5	-0.5	0.3	-0.6	0.2	0.2	0.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.9	1.2	0.9	1.4	-1.3	1.1	1.0	1.1	1.2	1.0
Medication: Ramipril	0.3	0.4	1.7	0.5	0.3	0.7	-0.1	1.3	0.2	0.8	0.7	0.4
Medication: Simvastatin	0.2	0.3	1.4	-1.2	-0.3	-0.6	0.0	0.5	-0.7	-0.2	-0.2	-0.2
Fluid intelligence score	0.4	0.9	5.3	1.0	0.2	0.3	2.3	1.1	0.5	0.5	0.1	0.3
Illnesses of siblings	0.4	0.5	2.9	1.7	0.2	0.3	0.6	0.2	-0.8	0.4	0.4	0.4
Neuroticism score	2.5	5.3	9.5	2.9	2.0	2.7	-1.0	1.3	3.1	2.1	2.3	2.5
Weight	0.3	1.4	3.5	1.2	0.8	1.6	-0.7	1.9	0.5	1.1	1.2	0.8
Impedance of arm (right)	13.7	63.8	81.2	-7.0	-8.5	-8.4	7.1	-6.0	-7.6	-9.0	-8.7	-8.9
Arm fat percentage (right)	0.2	0.9	2.2	-0.3	-1.4	-0.3	0.9	0.7	-0.8	-1.1	-0.9	-1.5
Trunk fat-free mass	1.4	7.8	9.9	2.8	3.0	2.6	-3.1	2.3	1.7	3.1	3.1	3.1
Hip circumference	0.2	0.9	1.7	1.3	0.7	1.2	0.5	1.2	0.4	1.0	1.0	0.6
Time employed in main current job	0.5	0.6	3.2	-1.8	-0.6	0.2	-0.6	-0.5	0.5	-0.6	-0.4	-0.4
Alcohol intake versus 10 years previously	0.2	0.4	1.4	-0.9	0.3	0.4	-0.8	0.2	1.2	0.1	0.5	0.1
Father’s age at death	0.3	0.4	2.2	1.5	0.5	0.3	-0.4	-0.1	-0.1	0.6	0.5	0.5
Worrier / anxious feelings	3.8	7.2	9.9	3.2	2.7	2.7	-2.4	1.5	3.1	2.6	2.7	3.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	0.0	-0.8	0.4	0.1	-1.1	0.6	-0.1	-0.4	-0.2
Falls in the last year	0.1	0.1	0.5	0.3	0.0	0.0	-0.5	-0.3	0.7	-0.1	-0.3	-0.2
Hair/balding pattern: Pattern 3	0.5	0.8	2.5	-0.7	0.6	0.9	-0.4	1.6	1.1	0.8	0.6	1.1
Number of live births	2.1	3.0	4.6	-2.1	-1.8	-1.3	1.6	-1.9	-1.5	-1.7	-1.6	-1.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.8	1.4	1.4	0.6	-0.1	0.0	-0.5	1.4	1.4	1.7
Pulse rate	5.9	9.9	16.3	-2.4	-2.9	-4.0	2.9	-2.2	-4.0	-3.0	-3.3	-3.1
Happiness	2.8	3.4	8.8	3.0	1.7	1.8	-0.5	1.7	1.1	2.0	2.0	1.8
Noisy workplace	1.0	1.2	3.0	-1.7	-1.1	-0.9	0.2	-1.3	-0.4	-1.3	-0.9	-1.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	1.1	0.4	-0.3	1.1	0.3	-0.9	0.5	0.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.6	1.6	1.3	0.6	-1.4	0.8	1.0	0.7	0.9	1.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.8	-0.9	0.2	-0.3	0.4	-0.2	-0.1	-0.1	0.0	-0.1
Asthma	3.8	7.5	13.8	-3.7	-2.9	-2.9	1.5	-2.1	-1.8	-3.2	-3.2	-2.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	1.1	0.5	-0.2	-1.2	0.1	0.1	0.1	0.0	0.5
Medication: Cholesterol lowering	0.2	0.4	0.8	0.5	0.5	0.9	-0.2	0.7	0.6	0.6	0.7	0.6
Depression (self-reported)	0.3	0.4	2.7	0.6	0.1	0.4	1.6	-0.2	0.1	0.1	0.0	0.2
Medication: Lansoprazole	2.5	2.9	4.1	1.6	2.0	1.3	-1.6	1.4	1.4	2.0	1.8	2.0
Prospective memory result	3.2	3.9	6.5	0.5	1.8	2.1	-2.5	2.0	2.3	2.0	2.0	1.8
Lung cancer (father)	0.3	0.4	0.7	0.7	0.8	0.0	0.0	0.6	-0.7	0.8	0.6	0.6
Illnesses of mother	0.1	0.2	0.6	0.1	-0.4	0.4	0.8	-0.2	-0.6	-0.1	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.0	1.7	1.1	0.4	0.2	-0.2	-0.5	1.1	1.0	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	2.3	-0.0	-0.2	0.7	1.1	1.2	1.5	-0.1	0.0	-0.0
Impedance of arm (left)	11.9	55.0	67.4	-6.8	-7.8	-7.6	6.6	-6.0	-7.2	-8.2	-8.0	-8.2
Arm fat mass (right)	0.2	0.8	2.6	0.8	0.3	1.4	-0.6	1.6	0.4	0.6	0.8	0.2
Trunk predicted mass	1.4	7.7	9.7	2.9	3.0	2.6	-3.0	2.3	1.6	3.1	3.0	3.1
Standing height	1.1	10.5	21.5	-2.7	-2.9	-3.6	2.6	-2.6	-4.6	-3.2	-3.2	-3.1
Length of working week for main job	0.5	0.6	1.4	-0.1	-1.1	-0.6	0.3	0.0	-0.3	-1.2	-0.9	-1.1
Exposure to tobacco smoke at home	1.1	1.3	3.2	-1.0	-1.0	-1.8	-0.1	-0.7	-1.0	-1.3	-1.4	-1.0
Breastfed as a baby	0.5	0.6	3.1	-0.1	0.1	1.1	0.1	1.8	-0.2	0.8	0.3	0.4
Tense / ‘highly strung’	0.2	0.3	1.5	0.3	-0.2	0.6	0.6	-0.2	1.2	-0.1	-0.0	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	0.1	-0.8	0.5	0.9	-0.1	-0.9	-0.4	-0.6	-0.4
Hair/balding pattern: Pattern 4	2.2	5.4	10.3	3.2	2.4	2.2	-1.1	1.7	2.7	2.2	2.5	2.3
Birth weight of first child	0.2	0.3	1.6	0.7	0.2	-0.0	0.7	1.3	-0.1	0.2	0.2	0.1
Peak expiratory flow (PEF)	1.9	4.4	6.8	2.0	2.3	2.4	-1.1	1.5	0.9	2.5	2.6	2.6
Pulse wave reflection index	1.0	1.3	4.1	-0.2	0.3	2.0	-0.7	1.0	2.0	0.7	0.9	0.7
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.0	1.0	1.0	1.7	0.0	0.9	1.2	1.1	1.3	1.0
Loud music exposure frequency	0.8	0.8	2.3	-0.7	-0.9	-0.9	-0.3	-0.6	-1.5	-1.0	-0.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	1.2	0.7	0.1	0.3	0.5	-0.1	1.1	0.5	0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.8	0.9	0.0	0.4	0.6	0.1	0.1	0.0	-0.0	-0.0
Blood clot in the leg (DVT)	0.3	0.4	2.5	0.1	-0.2	-0.3	1.6	0.2	0.4	-0.3	-0.3	-0.3
Medication: Paracetamol	0.2	0.4	1.4	-0.7	0.0	1.0	-0.2	-0.2	1.2	0.6	0.4	0.2
Headache pain in last month	0.4	0.7	4.7	-0.7	-0.1	0.4	-0.9	-0.1	2.2	-0.0	-0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.1	-0.5	-0.6	-1.0	0.6	-0.1	-1.4	-0.6	-0.8	-0.5
Glaucoma (self-reported)	0.3	0.3	1.7	1.3	0.4	0.2	-0.4	-0.6	-0.4	0.2	0.4	0.4
Gout (self-reported)	1.4	1.9	5.4	0.2	-1.1	-1.6	2.3	0.8	-2.0	-1.1	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.3	0.6	0.6	-0.3	0.3	0.6	0.3	0.7	0.5
Medication: Amlodipine	1.4	2.0	3.6	1.3	1.9	1.1	-0.9	0.7	1.5	1.6	1.7	1.4
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.3	-1.8	-1.3	-1.3	0.4	-0.9	-0.9	-1.4	-1.4	-1.1
Birth weight	2.0	4.3	8.7	-0.9	-1.9	-2.6	1.4	-2.0	-3.0	-2.1	-2.2	-2.0
Chronic bronchitis/emphysema (mother)	1.8	2.1	4.5	-1.1	-1.7	-1.3	0.7	-1.4	-0.0	-2.1	-1.8	-1.7
High blood pressure (siblings)	0.7	1.0	2.0	-1.4	-0.8	-1.4	0.8	-0.8	-0.2	-0.9	-1.0	-1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	5.7	0.2	-1.1	-2.1	2.2	-2.0	-2.4	-1.4	-1.5	-1.0
Body fat percentage	0.3	1.0	2.5	-0.8	-1.5	-0.1	0.9	0.5	-0.8	-1.1	-0.9	-1.6
Leg fat percentage (right)	0.6	2.1	5.2	1.2	0.8	2.1	-1.1	2.3	1.3	1.3	1.4	0.9
Arm fat-free mass (right)	2.2	11.1	14.3	2.9	3.5	3.6	-3.4	2.6	2.6	3.8	3.7	3.6
Exposure to tobacco smoke outside home	0.5	0.6	2.8	0.2	0.1	-0.0	-1.4	-0.7	1.7	-0.0	0.0	0.2
Comparative body size at age 10	0.7	2.0	4.4	2.1	1.3	1.4	-0.9	1.3	-0.5	1.8	1.4	1.4
Number of full brothers	2.4	3.0	8.6	0.4	1.6	2.1	-0.6	2.9	1.9	1.3	1.8	1.6
Worry too long after embarrassment	2.4	4.0	10.0	3.2	1.9	1.8	-1.7	1.0	2.0	1.8	1.9	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	3.1	-1.3	-1.6	-0.7	1.8	-1.3	-1.3	-1.6	-1.4	-1.3
Wheeze or whistling in the chest in last year	1.8	3.2	10.0	-3.2	-2.0	-1.3	0.1	-1.6	-0.7	-2.0	-1.9	-1.7
Number of children fathered	0.7	0.8	1.7	0.0	1.2	0.7	-0.1	1.1	0.5	1.3	1.2	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.7	-0.1	-1.2	-0.2	-0.0	-1.3	-0.7	-0.6	-0.3
Age at first live birth	0.5	0.8	2.5	0.6	-0.2	-1.3	1.0	-1.0	-1.6	-0.6	-0.4	-0.4
Pulse wave peak to peak time	0.6	0.7	3.0	-0.1	0.1	-0.8	-1.0	-1.2	-1.7	-0.1	-0.2	-0.1
Health satisfaction	0.2	0.3	1.6	0.6	0.1	0.7	0.2	0.5	1.3	0.2	0.3	0.2
Shortness of breath walking on level ground	0.3	0.4	1.2	-0.4	-0.7	-0.5	0.4	-0.2	-0.1	-0.8	-0.7	-1.1
Qualifications: College or University degree	0.2	0.6	3.0	0.7	-0.2	-0.9	1.7	0.7	-0.2	-0.5	-0.5	-0.2
Eye problems/disorders: None of the above	0.5	0.5	1.2	-1.1	-0.8	-0.6	-0.3	-0.7	-0.8	-0.6	-0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.1	-0.4	-0.5	0.5	-0.2	-0.2	-0.6	-0.6	-0.6
Emphysema/chronic bronchitis	0.5	0.6	2.0	-1.4	-0.8	-0.3	-0.7	-0.1	0.2	-0.9	-1.0	-0.4
Medication for pain relief, constipation, heartburn	2.2	3.7	6.4	-0.8	-1.7	-2.5	2.0	-1.2	-2.5	-2.1	-1.9	-2.0
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.9	-0.5	0.4	0.5	0.4	0.9	-0.3	-0.2	-0.4
Medication: Blood pressure	0.2	0.3	1.1	0.3	0.2	1.0	-0.4	-0.5	1.0	0.3	0.5	0.1
Angina (self-reported)	1.1	1.5	2.4	0.4	1.2	1.5	-1.0	0.2	1.4	1.4	1.3	1.5
Migraine (self-reported)	3.2	4.0	9.2	-3.0	-1.7	-2.2	0.4	-2.2	-1.7	-1.8	-2.0	-2.0
Medication: Ibuprofen	0.1	0.2	0.6	0.6	0.0	0.0	-0.8	0.1	0.6	-0.3	-0.3	0.1
Medication: Allopurinol	2.0	2.7	5.5	-0.4	-1.7	-1.6	2.3	-0.3	-2.1	-1.7	-1.6	-1.7
Medication: Omeprazole	0.1	0.2	0.5	0.3	0.2	0.7	0.2	0.4	0.6	0.2	0.2	0.0
Medication: Seretide 50 evohaler	5.5	6.3	12.0	-3.5	-2.6	-2.8	-0.3	-1.7	-2.0	-3.0	-2.6	-2.7
Mean time to correctly identify matches	1.0	2.0	3.3	-1.3	-1.5	-1.8	0.4	-0.4	-1.5	-1.5	-1.7	-1.7
Heart disease (mother)	1.1	1.3	4.8	-2.2	-1.3	-0.7	0.7	-0.1	-0.7	-1.1	-1.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.4	0.7	-0.2	-0.4	0.4	0.3	0.5	0.2	0.5
Whole body fat mass	0.1	0.2	0.8	-0.1	-0.6	0.7	0.2	0.9	-0.2	-0.1	0.0	-0.6
Leg fat mass (right)	0.4	1.7	4.2	1.2	0.7	2.1	-0.8	1.9	1.0	1.3	1.3	0.8
Arm predicted mass (right)	2.3	12.0	15.1	3.2	3.6	3.8	-3.5	2.8	2.6	3.9	3.8	3.8
Pulse rate, automated reading	7.2	23.2	29.6	-4.3	-5.1	-5.4	3.6	-4.4	-4.2	-5.4	-5.4	-5.1
Alcohol intake frequency.	0.6	1.4	4.8	-1.2	0.8	1.0	-2.2	0.1	1.6	0.6	0.9	0.8
Comparative height size at age 10	0.1	0.6	2.2	-0.3	-0.5	-1.0	0.5	-0.7	-1.5	-0.6	-0.6	-0.8
Number of full sisters	1.6	2.0	3.1	-1.3	-1.8	-0.9	1.5	-1.1	-0.7	-1.6	-1.6	-1.8
Suffer from ‘nerves’	0.9	1.5	3.2	1.8	1.1	1.3	0.4	1.0	1.7	1.0	1.0	1.3
Overall health rating	0.5	1.1	2.3	-1.4	-1.4	-0.2	0.2	-1.5	0.2	-1.0	-1.0	-1.1
Chest pain or discomfort	0.9	1.3	5.2	-0.1	0.7	1.5	-0.7	0.3	2.3	0.8	1.0	1.1
Had major operations	0.2	0.3	1.5	-0.4	-0.1	0.2	1.2	0.4	0.8	-0.0	0.2	-0.1
Age at last live birth	4.3	6.2	11.3	-0.9	-2.0	-3.4	1.9	-2.9	-3.2	-2.5	-2.3	-2.4
Family relationship satisfaction	1.9	2.3	4.0	2.0	1.5	1.6	-0.9	1.1	1.5	1.7	1.7	1.4
Leg pain on walking	0.8	1.0	3.1	-0.2	-0.9	-1.1	1.8	0.2	-0.7	-0.9	-0.9	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.2	1.0	1.1	1.2	-0.3	1.1	0.3	1.2	1.5	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	-0.5	0.3	0.6	-0.6	1.1	0.6	0.1	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.3	0.5	0.4	0.7	-0.5	0.3	0.4	0.5	0.6
Medication: Aspirin	1.1	1.4	2.2	0.5	1.4	1.4	-1.1	1.0	0.7	1.5	1.4	1.4
Supplements: Vitamin C	0.3	0.4	1.0	0.4	0.6	0.5	-0.9	-0.1	1.0	0.5	0.5	0.6
Knee pain experienced in last month	0.2	0.3	0.7	-0.6	-0.8	-0.1	0.8	0.4	-0.7	-0.2	-0.4	-0.6
Hypertension (Self-reported)	2.1	5.8	8.9	2.2	2.3	2.6	-2.2	1.9	3.0	2.5	2.6	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	4.6	1.4	1.5	1.6	-2.1	0.2	1.1	1.9	1.6	1.6
Illnesses of father: Heart disease	0.1	0.2	0.7	-0.8	-0.3	-0.3	-0.1	0.0	0.3	-0.6	-0.3	-0.3
Illnesses of siblings: Diabetes	0.3	0.3	1.8	0.4	0.4	0.2	-1.4	0.1	0.5	0.3	0.4	0.4
Smoking status: Previous	0.7	1.0	1.5	-0.7	-1.0	-1.1	0.6	-0.6	-1.2	-1.2	-1.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.4	1.5	0.7	0.2	-0.3	0.6	0.5	0.7	0.6	0.8
Whole body fat-free mass	0.9	5.2	6.3	2.3	2.4	2.3	-2.4	1.9	1.4	2.5	2.5	2.5
Leg fat-free mass (right)	0.2	0.9	1.4	1.1	0.9	1.2	-0.7	1.2	0.5	1.0	1.1	0.8
Arm fat percentage (left)	0.2	0.7	1.8	-0.3	-1.2	-0.0	0.8	0.6	-0.8	-0.9	-0.8	-1.4
Average weekly red wine intake	0.2	0.4	1.6	0.2	0.3	-0.5	1.0	0.5	-1.3	0.2	0.0	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.3	-0.1	-0.4	-0.7	0.2	0.3	-1.1	-0.7	-0.5	-0.5
Mood swings	1.1	1.9	5.8	1.3	1.2	1.5	-0.9	-0.1	2.4	1.1	1.5	1.4
Loneliness, isolation	2.3	3.2	9.8	-0.8	0.6	2.6	-2.7	0.5	3.1	1.1	1.3	1.0
Long-standing illness, disability or infirmity	2.5	3.8	12.2	-3.5	-2.3	-1.1	1.0	-1.2	-1.1	-1.9	-1.9	-2.3
Ever had bowel cancer screening	0.6	0.7	1.8	-1.3	-0.3	-1.3	0.1	-0.8	-1.0	-0.7	-0.7	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.9	0.5	0.5	-0.3	-0.9	0.6	-0.5	0.7	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	0.4	0.2	1.2	-0.4	0.3	1.2	0.7	0.6	0.3
Friendships satisfaction	5.1	6.3	10.8	3.3	2.8	2.5	-1.5	1.6	2.0	2.8	2.8	2.8
Qualifications: nursing, teaching	0.2	0.3	1.5	0.2	0.5	-0.1	-0.6	1.2	-0.3	0.5	0.4	0.4
Commuting to job workplace: Walk	1.6	1.7	2.9	1.5	1.5	1.1	-1.0	0.5	1.4	1.4	1.2	1.7
Eye problems/disorders: Cataract	0.3	0.4	1.8	0.1	0.4	0.3	0.7	0.6	1.4	0.4	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.5	-0.8	-0.8	-0.1	1.2	-0.4	0.1	-0.5	-0.7	-0.6
Medication for cholesterol	1.4	2.1	4.7	-0.8	-1.5	-1.4	1.3	-2.2	-0.9	-1.7	-1.5	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.7	-0.0	0.9	-0.1	0.1	-0.5	0.5	0.4	0.0
Back pain experienced in last month	0.4	0.5	2.1	-0.4	0.3	1.4	-0.6	-0.1	0.9	0.6	0.7	0.5
Mineral and other dietary supplements	0.3	0.4	1.5	0.0	0.4	0.8	-0.2	-0.4	1.2	0.5	0.6	0.6
Breast cancer (self-reported)	1.1	1.3	3.5	1.1	1.4	0.9	0.1	1.9	0.6	1.1	1.3	1.2
Asthma (self-reported)	4.0	7.9	13.9	-3.7	-3.0	-2.9	1.8	-2.1	-2.0	-3.2	-3.2	-2.8
Osteoporosis (self-reported)	1.2	1.4	4.7	-2.2	-0.6	-1.3	-0.7	-1.4	-0.5	-1.2	-1.1	-0.8
Osteoarthritis (self-reported)	1.5	2.0	4.8	-2.2	-1.7	-0.6	0.4	-1.6	-1.0	-1.2	-1.2	-1.7
Medication: Aspirin	0.7	0.9	1.4	0.3	1.1	1.2	-1.0	0.6	0.3	1.1	1.1	1.2
Medication: Gliclazide	0.7	0.8	1.1	1.0	1.1	0.6	-0.6	1.1	0.2	1.0	1.1	1.1
Illnesses of father: None of the above (group 1)	0.3	0.4	2.4	0.1	-0.4	-0.8	0.1	-0.1	-1.5	-0.4	-0.4	-0.4
Smoking status: Current	0.5	0.8	4.9	-2.2	-0.6	-0.5	0.1	-1.0	-0.2	-0.6	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.6	2.1	1.7	1.8	-0.4	1.0	1.1	2.0	2.0	1.8
Whole body water mass	0.9	5.2	6.3	2.4	2.4	2.2	-2.4	2.0	1.5	2.5	2.5	2.5
Leg predicted mass (right)	0.2	0.9	1.4	1.1	0.8	1.2	-0.8	1.2	0.5	1.0	1.1	0.8
Arm fat mass (left)	0.2	0.8	2.1	0.8	0.4	1.4	-0.7	1.3	0.6	0.7	0.9	0.4
Number of self-reported non-cancer illnesses	1.0	1.7	2.6	-1.6	-1.6	-1.1	0.8	-1.3	-0.6	-1.3	-1.4	-1.6
Average weekly champagne plus white wine intake	0.8	1.1	3.6	0.2	-1.0	-0.9	0.4	-1.3	-1.9	-0.9	-1.0	-1.0
Miserableness	2.3	4.0	9.5	3.1	1.7	2.4	-0.5	1.1	1.9	2.2	2.1	1.9
Guilty feelings	3.5	5.2	9.5	3.1	2.2	1.9	-1.5	1.9	2.3	2.2	2.4	2.6
Wears glasses or contact lenses	2.1	2.5	4.9	-0.7	-1.8	-1.3	2.2	0.2	-0.5	-2.0	-1.9	-2.0
Ever taken oral contraceptive pill	1.1	1.3	2.2	-0.4	-1.3	-1.2	0.7	-1.2	-0.8	-1.2	-1.4	-1.5
Hearing aid user	0.9	1.0	2.2	-1.2	-1.4	-0.3	1.5	-0.6	-0.4	-0.9	-1.0	-1.2
Mother’s age at death	0.6	0.8	2.2	1.5	0.5	-0.4	1.2	1.5	-0.3	0.7	0.2	0.5
Financial situation satisfaction	0.1	0.2	1.1	0.1	-0.2	-0.0	-0.3	-0.4	1.1	-0.1	0.0	-0.1
Tinnitus: Yes, now most or all of the time	2.4	2.7	4.3	-0.6	-1.4	-1.7	2.1	-1.7	-2.0	-1.7	-1.7	-1.7
Commuting to job workplace: Public transport	0.2	0.2	0.8	0.6	-0.1	-0.5	0.9	-0.5	-0.3	0.1	-0.3	-0.2
Eye problems/disorders: Glaucoma	0.8	0.9	4.0	2.0	0.9	0.7	-0.3	0.7	0.3	0.8	1.0	0.8
Medication: Blood pressure	1.9	3.7	6.1	1.4	2.1	1.7	-1.6	2.5	1.4	2.4	2.0	2.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	-1.3	-1.2	-0.5	0.3	-0.0	-0.5	-1.2	-1.1	-1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.2	0.1	-0.4	-0.2	0.2	0.6	-1.1	-0.2	-0.3	-0.4
High cholesterol (Self-reported)	1.5	2.6	5.4	1.3	1.9	1.4	-1.3	1.0	0.7	2.3	2.0	1.9
Medication: Bendroflumethiazide	0.2	0.2	1.6	-0.1	-0.3	-0.1	0.1	-1.3	-0.2	-0.4	-0.4	-0.3
Medication: Paracetamol	0.2	0.2	0.6	-0.8	-0.6	0.4	0.6	-0.4	0.2	-0.2	-0.3	-0.5
Medication: Lisinopril	0.1	0.1	0.3	0.1	-0.3	-0.3	0.5	-0.6	-0.0	-0.2	-0.2	-0.5
Medication: Atorvastatin	2.8	3.5	6.4	1.7	2.0	2.2	-0.9	0.8	1.6	2.5	2.2	2.1
Illnesses of father: High blood pressure	0.3	0.4	2.3	0.4	0.2	0.6	0.1	-0.4	1.5	0.2	0.3	0.2
Alcohol drinker status: Never	0.3	0.4	1.8	-1.3	0.5	-0.0	-0.9	-0.1	0.4	0.3	0.3	0.4
Ever smoked	0.4	0.7	1.2	-0.7	-0.8	-1.0	0.6	0.3	-1.1	-0.8	-0.9	-1.0
Basal metabolic rate	0.7	3.8	4.8	2.0	2.0	2.1	-2.0	1.8	1.2	2.1	2.2	2.0
Leg fat percentage (left)	1.1	3.9	8.6	1.4	1.3	2.9	-1.5	2.8	2.0	1.8	2.0	1.4
Arm fat-free mass (left)	2.0	10.0	12.2	2.9	3.2	3.3	-3.3	2.8	2.4	3.5	3.5	3.4
Number of operations (self-reported)	0.8	1.3	3.0	0.4	1.0	1.7	0.3	0.6	1.5	1.2	1.4	1.0
Average weekly beer plus cider intake	0.4	0.5	1.3	-0.6	-0.6	-1.1	-0.2	-1.0	0.6	-0.7	-0.7	-0.6
Irritability	4.0	6.7	13.7	2.2	2.5	3.0	-1.7	1.1	3.7	2.8	2.7	2.7
Risk taking	0.4	0.6	1.2	-1.0	-0.9	-0.6	0.1	-0.5	0.1	-0.9	-0.7	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	0.5	1.1	0.1	-0.6	0.5	0.1	1.0	1.0	0.9
Fractured/broken bones in last 5 years	2.6	3.4	6.6	-2.6	-1.2	-2.3	0.9	-1.5	-2.5	-1.5	-1.8	-1.6
Age started oral contraceptive pill	3.1	3.9	5.7	-2.4	-1.8	-2.0	2.3	-0.9	-1.9	-1.9	-2.1	-1.9
Diastolic blood pressure, automated reading	4.8	14.8	22.2	4.0	4.0	3.7	-4.7	1.6	3.3	4.1	4.1	4.2
Ever depressed for a whole week	2.2	2.7	6.1	-0.7	-1.7	-1.2	2.5	-0.6	-2.1	-1.7	-1.6	-1.8
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.6	-0.5	-0.6	-0.1	0.0	0.3	-0.5	-0.6	-0.7
Commuting to job workplace: Cycle	0.3	0.4	1.5	-0.7	-0.7	-0.2	1.2	0.1	-0.2	-0.5	-0.5	-0.6
Myopia	0.7	1.0	1.5	0.7	1.1	0.8	-1.1	0.6	1.1	1.2	1.2	1.2
Vascular/heart problems diagnosed by doctor	2.7	7.2	9.1	-2.4	-2.7	-2.8	2.7	-2.1	-3.0	-2.8	-3.0	-2.6
Cholesterol lowering medication	0.8	1.2	3.0	0.4	1.1	0.8	-0.7	1.4	-0.2	1.7	1.3	1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	0.9	0.7	1.1	-0.5	0.9	1.2	0.8	0.7	0.6
Pain experienced in last month	0.3	0.5	1.5	1.2	1.0	-0.3	-0.6	-0.1	0.1	0.6	0.6	0.6
Supplements: Calcium	1.0	1.1	1.7	-1.0	-1.0	-1.3	-0.0	-1.1	-0.8	-1.1	-1.3	-1.3
Basal cell carcinoma (self-reported)	0.2	0.2	1.2	-0.2	-0.3	0.0	0.8	0.3	-1.1	-0.2	-0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-1.1	-0.7	-0.5	-0.5	-0.4	-0.6	-0.5	-0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	2.1	0.1	-0.2	-0.3	1.5	0.3	0.3	-0.3	-0.3	-0.3
Heart disease (siblings)	0.7	0.8	4.2	-2.0	-0.5	-0.2	-1.1	-0.9	0.4	-0.7	-0.5	-0.5
Alcohol drinker status: Previous	0.6	0.7	1.2	-0.4	-0.9	-0.6	1.0	-0.3	-0.8	-1.0	-0.9	-1.1
Pack years of smoking	2.4	3.5	4.9	-2.2	-2.2	-1.3	1.3	-1.8	-1.5	-2.1	-2.1	-2.2
Impedance of whole body	5.9	29.9	36.0	-5.1	-5.7	-5.5	4.9	-4.5	-5.4	-6.0	-5.9	-6.0
Leg fat mass (left)	0.7	2.7	6.8	1.3	1.0	2.6	-1.1	2.3	1.4	1.6	1.7	1.2
Arm predicted mass (left)	2.1	10.4	12.6	3.0	3.3	3.3	-3.4	2.9	2.4	3.5	3.5	3.5