TWAS hub - USP35

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0280	2.7e-04	0.046	0.038	0.017	0.038	0.030	2.5e-06	1.6e-05	3.0e-03	2e-05	1.3e-04
2	GTEx	Brain Cerebellar Hemisphere	0.1860	0.0980	1.6e-03	0.075	NA	0.091	NA	0.065	5.8e-03	NA	2.5e-03	NA	9.3e-03
3	GTEx	Nerve Tibial	0.1364	0.0470	8.9e-05	0.141	NA	0.080	NA	0.111	3.4e-10	NA	2.5e-06	NA	3.0e-08
4	GTEx	Testis	0.0750	0.0390	5.1e-03	0.064	NA	0.040	NA	0.067	8.4e-04	NA	6.8e-03	NA	6.4e-04
5	METSIM	Adipose	0.0492	0.0213	7.3e-06	0.047	0.030	0.034	0.035	0.037	1.1e-07	2.4e-05	7.5e-06	5e-06	3.0e-06
6	TCGA	Brain Lower Grade Glioma	0.1401	0.0452	2.2e-09	0.129	0.098	0.122	NA	0.126	1.8e-14	2.9e-11	9.3e-14	NA	3.9e-14
7	TCGA	Prostate Adenocarcinoma	0.1174	0.0586	2.2e-03	0.018	0.023	0.018	NA	0.020	4.7e-03	1.5e-03	5.2e-03	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Impedance of arm (right)	9.3	43.5	76.1	7.7	8.7	1.0	8.7	8.6	0.8	4.2
Hair Pigment	9.0	257.7	458.0	-17.4	-21.4	-2.3	-21.4	-21.4	-2.3	-10.8
Impedance of arm (left)	7.9	36.6	64.5	7.1	7.9	0.2	8.0	7.9	0.1	4.0
Lung FEV1/FVC ratio	7.1	36.1	57.1	-7.5	-7.6	-2.6	-7.3	-7.5	-2.5	-4.1
Age when periods started (menarche)	6.7	16.0	31.5	2.9	5.3	2.7	5.5	5.6	2.4	0.8
LDL Cholesterol	6.0	9.5	16.2	-3.8	-3.8	0.3	-4.0	-4.0	-0.0	-2.3
Alcohol usually taken with meals	5.7	9.2	18.3	-4.0	-3.3	0.7	-3.1	-3.1	0.6	-4.3
Neuroticism	5.5	13.2	27.3	-2.2	-4.9	1.5	-5.2	-4.8	1.5	-2.9
Townsend deprivation index at recruitment	5.5	7.7	12.7	3.5	3.6	-0.3	3.3	3.4	-0.2	2.4
Body Mass Index (BMI) (2010)	5.4	7.4	11.6	-3.4	-3.2	0.6	-3.4	-3.4	0.4	-2.7
Diastolic blood pressure, automated reading	5.2	16.0	19.6	-3.6	-4.2	-4.2	-4.1	-4.1	-4.4	-3.4
HbA1C	4.5	5.0	11.5	-2.9	-3.4	1.3	-1.8	-2.2	0.5	-2.2
Sensitivity / hurt feelings	4.4	7.5	13.8	-2.1	-3.7	0.1	-3.7	-3.6	0.1	-2.7
Medication: Lansoprazole	4.2	4.7	10.6	-2.6	-2.4	-0.6	-2.2	-2.1	-0.7	-3.3
Pulse rate, automated reading	4.1	13.1	24.7	3.9	4.9	0.7	4.9	5.0	0.6	2.0
Friendships satisfaction	4.1	5.0	8.6	-2.8	-2.9	0.3	-2.8	-2.8	0.2	-1.8
Hair/balding pattern: Pattern 2	4.0	5.1	10.2	2.2	3.1	0.2	3.2	3.0	0.3	1.2
Medication: Seretide 50 evohaler	4.0	4.6	6.9	2.5	2.6	-1.2	2.6	2.6	-1.3	1.7
Impedance of whole body	3.8	19.5	35.9	5.2	5.6	0.1	6.0	5.9	0.0	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.8	5.2	-2.3	-1.7	-2.1	-1.6	-1.6	-2.1	-2.2
Neuroticism (Nagel 2018)	3.2	7.5	17.3	-1.3	-4.0	0.1	-4.2	-3.9	-0.0	-1.5
Medication: Atenolol	3.1	3.9	5.7	-2.4	-2.4	-1.3	-2.3	-2.3	-1.0	-1.7
Medication: Atorvastatin	3.1	3.9	8.7	-3.0	-2.2	-0.4	-1.8	-1.9	-0.6	-2.5
Medication: Allopurinol	2.9	3.8	7.7	1.6	1.9	-2.6	1.8	1.8	-2.8	-0.3
Ulcerative Colitis (UC)	2.8	5.3	11.4	2.0	3.4	-0.5	3.1	3.3	-0.6	1.0
Chronic bronchitis/emphysema (mother)	2.8	3.3	5.9	2.1	1.5	2.4	1.5	1.7	2.4	0.4
Wears glasses or contact lenses	2.8	3.2	6.0	2.4	2.3	0.8	1.9	1.8	1.0	1.6
Cardiovascular Disease	2.6	8.5	12.4	-2.5	-3.5	-2.8	-3.5	-3.3	-2.6	-1.8
Schizophrenia (2018)	2.4	5.0	8.6	-1.7	-2.5	1.9	-2.2	-2.4	1.9	-2.9
Triglycerides	2.4	3.9	8.4	-2.9	-2.6	-0.4	-2.3	-2.5	-0.6	-0.5
Average weekly fortified wine intake	2.4	2.8	6.6	0.9	2.6	0.8	2.2	2.5	0.5	0.4
Peak expiratory flow (PEF)	2.4	5.5	9.5	-3.1	-2.9	-1.7	-2.6	-2.5	-1.9	-0.7
Long-standing illness, disability or infirmity	2.4	3.6	6.1	2.1	2.5	0.6	2.5	2.4	0.9	1.4
High cholesterol (Self-reported)	2.4	4.2	9.1	-3.0	-1.8	-1.6	-1.6	-1.9	-1.8	-2.3
Taking other prescription medications	2.3	3.5	7.2	2.2	2.7	-0.5	2.3	2.3	-0.6	1.2
Pulse rate	2.3	3.9	8.9	1.3	3.0	-0.4	2.8	2.8	-0.5	0.8
Worrier / anxious feelings	2.2	4.2	10.1	-0.5	-2.8	-0.9	-3.2	-2.8	-1.2	-1.3
Age started oral contraceptive pill	2.2	2.7	4.8	2.1	2.2	-0.0	2.0	1.8	-0.3	1.5
Chronotype (morning person)	2.1	4.7	11.2	-1.1	-3.1	0.7	-3.2	-3.3	0.8	-0.2
Asthma (self-reported)	2.1	4.1	8.2	2.5	2.5	-0.2	2.9	2.9	-0.0	0.2
Cholesterol lowering medication	2.1	3.1	5.5	-2.4	-1.0	-2.3	-1.1	-1.2	-2.1	-1.6
Ulcerative Colitis	2.0	2.9	5.9	1.1	2.4	-0.8	2.1	2.4	-0.9	1.3
Hand grip strength (right)	2.0	5.3	13.9	-3.7	-2.4	2.5	-1.6	-1.5	2.0	-1.6
Asthma	2.0	3.9	7.6	2.5	2.5	-0.1	2.7	2.8	0.1	0.2
Migraine (self-reported)	2.0	2.4	3.7	1.2	1.9	1.5	1.9	1.7	1.2	1.4
Number of full sisters	2.0	2.4	4.0	2.0	1.6	-1.0	1.8	1.8	-1.1	1.4
Guilty feelings	2.0	3.0	7.0	-1.0	-2.5	-0.3	-2.7	-2.4	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	2.0	5.3	7.4	1.9	2.3	2.6	2.7	2.7	2.2	1.4
Pack years of smoking	2.0	2.9	5.6	2.1	2.4	-0.3	2.2	2.2	-0.2	0.7
Bipolar Disorder or Schizophrenia	1.9	4.5	5.8	-0.4	-2.4	2.2	-2.3	-2.4	2.1	-2.3
Schizophrenia (2014)	1.9	4.2	7.5	-0.8	-2.0	2.7	-1.7	-1.8	2.6	-2.0
Arm predicted mass (right)	1.9	9.7	19.9	-4.5	-4.0	0.1	-3.9	-3.8	0.0	-1.5
Age at last live birth	1.9	2.7	4.2	1.7	2.0	-0.9	2.0	1.9	-0.8	1.6
Irritability	1.9	3.1	6.7	-0.7	-2.3	-0.1	-2.6	-2.4	-0.1	-2.0
Worry (Nagel 2018)	1.8	3.9	8.2	-0.4	-2.9	0.8	-2.9	-2.7	0.4	-1.6
Tanning	1.8	22.4	41.0	5.1	6.4	1.3	6.4	6.2	1.2	2.8
Pack years adult smoking proportion	1.8	2.7	4.8	2.2	2.1	-0.5	1.9	2.0	-0.5	0.9
High blood pressure (mother)	1.8	2.5	3.9	-1.4	-2.0	1.5	-1.8	-1.8	1.3	-1.1
Financial difficulties in last 2 years	1.8	2.5	5.0	2.2	1.3	-1.3	1.2	1.6	-1.1	1.9
Arm fat-free mass (right)	1.8	9.1	18.8	-4.3	-3.9	-0.1	-3.8	-3.7	-0.1	-1.6
Wheeze or whistling in the chest in last year	1.8	3.2	4.6	1.7	1.8	-2.0	1.8	1.9	-2.1	0.2
Eye problems/disorders: Cataract	1.8	2.0	7.0	0.1	-0.4	2.6	-0.4	-0.5	2.6	0.1
Heel T-Score	1.7	13.4	25.4	-3.1	-4.7	-2.3	-5.0	-4.8	-2.5	-1.6
BMI	1.7	10.1	17.6	-4.0	-4.2	-1.3	-4.2	-4.1	-1.1	-0.7
High blood pressure	1.7	4.6	8.0	-1.4	-2.3	-2.1	-2.8	-2.8	-1.8	-1.4
Allergy	1.7	3.8	6.5	-2.4	-2.5	0.6	-2.4	-2.5	0.6	-1.2
Prospective memory result	1.7	2.1	3.7	-1.6	-1.6	-1.1	-1.8	-1.9	-1.0	-0.5
Medication for pain relief, constipation, heartburn	1.7	2.8	5.1	1.4	2.0	1.3	1.6	1.8	1.2	2.2
Medication for cholesterol	1.7	2.6	5.3	1.4	1.3	2.3	1.4	1.6	2.1	0.2
Medication: Blood pressure	1.7	3.2	5.1	-2.3	-2.0	-1.5	-2.1	-2.1	-1.4	-0.5
Arm predicted mass (left)	1.7	8.7	18.6	-4.3	-3.6	0.1	-3.8	-3.6	0.2	-1.4
Allergy or Eczema	1.6	4.2	6.8	2.6	2.5	-0.4	2.5	2.5	-0.1	1.9
Exposure to tobacco smoke at home	1.6	1.8	4.9	1.6	1.0	-2.2	0.8	1.0	-1.7	0.1
Commuting to job workplace: Walk	1.6	1.7	3.6	-1.2	-1.9	0.6	-1.4	-1.6	0.3	-1.3
Arm fat-free mass (left)	1.6	8.3	17.9	-4.2	-3.6	0.1	-3.7	-3.5	0.1	-1.4
Irritable Bowel Disease (IBD)	1.5	3.5	7.8	1.6	2.6	-0.3	2.7	2.8	-0.2	-0.1
Smoking Status	1.5	3.6	5.9	2.4	2.4	0.0	2.4	2.2	0.2	1.8
Hand grip strength (left)	1.5	3.9	12.7	-3.6	-2.1	1.4	-1.8	-1.7	1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.3	6.1	-2.2	-2.5	-0.8	-2.3	-2.2	-0.9	-0.8
Number of live births	1.5	2.2	4.1	0.9	2.0	-1.1	1.8	1.8	-1.3	1.1
Happiness	1.5	1.9	3.6	-1.2	-1.8	-0.9	-1.9	-1.7	-1.0	0.5
Worry too long after embarrassment	1.5	2.5	5.7	-0.9	-2.4	0.2	-2.4	-2.0	0.4	-1.0
Miserableness	1.5	2.7	3.9	-1.2	-1.7	-1.8	-1.9	-1.8	-2.0	-0.4
Neuroticism (2016)	1.4	2.0	5.3	-0.9	-2.1	0.4	-2.3	-1.4	0.9	-0.7
Respiratory disease	1.4	3.1	5.2	2.3	1.9	-1.3	2.2	2.3	-1.0	-0.6
Hearing difficulty/problems: Yes	1.4	2.1	3.9	2.0	1.1	1.6	1.5	1.4	1.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	4.2	-1.6	-1.9	-1.9	-1.8	-1.7	-2.0	-1.4
Qualifications: CSEs or equivalent	1.4	1.8	3.3	-0.6	-1.8	-1.4	-1.6	-1.5	-1.4	-0.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.4	-0.5	-0.9	-2.2	-1.0	-0.9	-2.3	-0.2
Length of working week for main job	1.4	1.5	3.3	1.8	1.4	0.2	1.0	1.1	0.0	1.8
Comparative body size at age 10	1.4	3.9	10.8	-3.3	-1.5	-1.7	-1.4	-1.3	-1.5	-2.4
Had major operations	1.4	1.6	5.2	0.4	0.5	2.2	0.0	0.1	2.3	0.8
Hypertension (Self-reported)	1.4	3.8	5.7	-1.4	-1.9	-2.1	-2.4	-2.3	-1.8	-1.3
Medication: Aspirin	1.4	1.9	4.2	-0.9	-1.0	-2.0	-1.1	-1.2	-2.0	-0.6
Hearing aid user	1.4	1.6	2.4	1.5	1.6	1.4	1.4	1.4	1.0	-0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	5.0	-0.5	0.8	2.0	0.9	0.9	2.2	0.0
Lupus	1.3	2.0	5.3	1.5	0.8	2.3	0.7	0.9	2.1	0.4
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.4	1.1	1.8	-0.2	1.6	1.8	-0.4	0.1
Relative age of first facial hair	1.3	2.6	4.8	1.6	2.2	0.2	2.1	2.0	0.1	1.6
Trunk fat-free mass	1.3	7.6	17.2	-4.2	-3.3	0.5	-3.4	-3.3	0.5	-1.4
Illnesses of mother	1.3	1.6	5.0	1.0	0.8	-2.2	0.4	0.4	-1.9	0.8
Trunk predicted mass	1.3	7.6	17.2	-4.2	-3.3	0.4	-3.4	-3.2	0.5	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.1	1.5	1.7	-0.5	1.7	1.8	-0.6	-0.3
Number of children fathered	1.3	1.4	4.3	-2.1	-1.0	0.1	-0.9	-1.2	-0.0	-1.5
Medication: Aspirin	1.3	1.7	2.3	-1.2	-1.3	-1.5	-1.2	-1.4	-1.5	-0.6
Osteoarthritis (self-reported)	1.3	1.7	3.9	0.9	2.0	0.0	1.8	1.8	0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.4	-1.4	-1.7	-2.1	-1.7	-1.7	-2.1	-0.0
Ever depressed for a whole week	1.3	1.6	3.2	1.4	1.5	-0.1	1.6	1.8	-0.1	-0.9
Depressed Affect (Nagel 2018)	1.2	2.6	5.7	-0.9	-2.2	-0.9	-2.4	-2.2	-0.9	-0.6
Bipolar Disorder (2011)	1.2	1.2	3.3	0.8	-0.1	1.8	-0.2	-0.2	1.8	-1.0
Coronary Artery Disease (CAD)	1.2	1.5	3.9	-0.4	-2.0	0.8	-1.6	-1.7	0.5	0.1
Fed-up feelings	1.2	2.2	3.3	-0.6	-1.3	-1.8	-1.5	-1.4	-1.8	-1.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.9	1.8	2.1	-0.3	2.2	2.2	-0.4	0.8
Neuroticism score	1.2	2.6	5.5	-0.4	-2.1	-0.2	-2.4	-2.0	-0.3	-1.9
Overall health rating	1.2	2.6	5.3	2.3	1.4	-2.0	1.1	1.4	-2.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.0	-2.0	-0.1	-1.0	0.4	0.2	-0.9	-2.0
Ever had prostate specific antigen (PSA) test	1.2	1.3	3.1	-1.8	-0.7	1.1	-1.0	-1.1	1.2	-0.9
Systolic Blood Pressure	1.1	5.3	8.4	-2.0	-2.9	-1.5	-2.3	-2.4	-1.7	-2.9
Body mass index (BMI)	1.1	4.5	8.0	-2.3	-2.5	-1.6	-2.8	-2.6	-1.5	0.2
Hair/balding pattern: Pattern 4	1.1	2.6	5.1	-1.7	-2.1	0.5	-2.2	-2.2	0.7	0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.8	1.0	0.0	-2.0	0.1	-0.0	-2.2	0.1
Gout (self-reported)	1.1	1.5	3.0	0.9	1.2	-1.5	1.0	1.0	-1.7	1.0
Angina (self-reported)	1.1	1.4	2.2	-1.3	-1.5	0.9	-1.0	-1.3	0.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.8	-1.4	-1.3	-1.0	-1.2	-1.2	-1.3	-0.0
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.7	0.2	1.3	1.1	1.6	1.6	1.0	-0.6
Average weekly beer plus cider intake	1.1	1.6	3.2	1.4	0.5	1.5	0.5	0.6	1.7	1.8
Risk taking	1.1	1.6	5.2	2.3	1.3	-1.0	1.0	1.0	-0.8	0.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.5	0.3	-1.3	-1.1	-1.6	-1.4	-1.1	-1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	1.1	1.5	-0.9	1.2	1.3	-1.0	-0.6
Chest pain or discomfort	1.0	1.4	2.9	1.3	-1.0	-1.5	-0.5	-0.7	-1.7	-1.1
Medication: Gliclazide	1.0	1.1	1.5	-1.2	-1.0	-0.9	-1.2	-1.1	-0.9	-0.8
Number of self-reported non-cancer illnesses	1.0	1.8	3.0	1.2	1.7	-1.6	1.3	1.4	-1.2	-0.2
Blood Red Count	0.9	8.3	17.6	2.6	4.2	0.5	3.9	4.1	0.2	1.0
Systolic blood pressure, automated reading	0.9	2.7	5.1	-1.2	-1.9	-1.0	-1.7	-1.8	-1.3	-2.2
Angina	0.9	1.2	1.9	-1.3	-1.4	0.9	-0.9	-1.2	0.8	-1.2
Medication for hormone replacement therapy	0.9	1.0	2.6	1.4	0.9	-0.5	0.9	0.7	-0.3	1.6
Trunk fat percentage	0.9	3.6	5.2	1.2	2.3	-1.5	2.1	2.2	-1.5	2.1
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.9	-0.7	-0.4	-1.4	-0.7	-0.6	-1.2	-1.2
Medication: Amlodipine	0.9	1.3	3.3	-1.0	-1.2	0.2	-1.6	-1.8	0.4	-0.8
Birth weight	0.9	1.9	4.3	0.4	2.1	1.2	1.7	1.8	1.1	0.1
Number of full brothers	0.9	1.2	2.5	-0.5	-1.2	0.8	-1.6	-1.6	0.8	0.5
Shortness of breath walking on level ground	0.9	1.0	1.7	1.3	1.0	-0.9	1.1	0.8	-1.1	0.7
Mean time to correctly identify matches	0.9	1.7	3.4	1.6	1.8	-0.3	1.6	1.4	-0.3	1.1
Loneliness, isolation	0.9	1.3	3.0	1.7	-0.5	-1.7	-0.6	-0.5	-1.3	0.9
Ever taken oral contraceptive pill	0.9	1.0	1.7	1.3	1.2	0.1	1.2	1.3	0.2	0.9
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.9	1.4	1.2	-0.6	1.2	1.3	-0.9	0.2
Illnesses of father: High blood pressure	0.9	1.1	3.9	0.1	-0.2	2.0	-0.0	-0.2	1.9	0.0
Commuting to job workplace: Cycle	0.9	1.1	2.8	1.2	0.8	1.0	0.6	0.8	0.7	1.7
Rheumatoid Arthritis	0.8	1.1	1.8	1.2	1.1	-0.3	1.2	1.3	-0.4	1.3
Waist Hip Ratio (WHR)	0.8	3.5	5.8	2.4	1.7	-2.3	1.7	1.7	-1.9	1.1
Number of treatments/medications taken	0.8	1.5	4.7	1.0	0.8	-2.2	0.5	0.4	-1.9	0.2
Number of incorrect matches in round	0.8	1.3	3.1	-1.8	-1.1	0.0	-1.1	-1.2	-0.0	-1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	6.5	-2.5	-1.9	0.1	-1.9	-1.6	0.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.6	-1.1	-1.1	0.7	-1.3	-1.2	0.5	-0.2
Lung cancer (father)	0.8	0.9	2.3	-1.5	-1.0	-0.5	-0.5	-0.8	-0.7	-1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.5	0.5	0.9	-0.7	1.1	1.3	-0.8	-1.6
Heart disease (mother)	0.8	1.0	2.1	1.0	0.8	0.5	1.5	1.4	0.7	-0.7
Family relationship satisfaction	0.8	1.0	2.3	-0.9	-1.5	-0.1	-1.3	-1.5	-0.2	-0.2
Supplements: Vitamin C	0.8	0.9	2.8	-0.5	-0.4	1.7	-0.7	-0.7	1.4	0.2
Illnesses of siblings: Diabetes	0.8	1.0	3.3	-0.2	-0.3	-1.8	-0.4	-0.4	-1.7	-0.2
Whole body fat-free mass	0.8	4.7	11.2	-3.3	-2.6	0.5	-2.7	-2.6	0.5	-0.8
Diabetes diagnosed by doctor	0.8	1.2	3.2	-1.8	-0.6	-1.3	-0.8	-0.6	-1.3	-0.9
Whole body water mass	0.8	4.7	11.0	-3.3	-2.6	0.6	-2.7	-2.5	0.6	-0.7
Commuting to job workplace: Public transport	0.8	1.0	2.5	0.6	0.3	-1.4	0.2	0.1	-1.4	1.6
Heart disease (siblings)	0.8	1.0	3.3	1.8	0.7	1.0	0.3	0.5	0.9	1.1
Alzheimer’s Disease (in father)	0.7	0.7	1.9	1.0	0.0	1.4	-0.1	-0.1	1.4	0.5
Alzheimer’s Disease (including proxy)	0.7	1.1	2.4	-1.6	-1.2	0.9	-1.1	-0.9	0.7	0.3
Reaction Time	0.7	1.4	2.2	1.5	1.4	-0.7	1.5	1.3	-0.6	0.9
Blood Platelet Count	0.7	7.7	12.5	-1.5	-3.5	2.0	-3.3	-3.5	1.9	-2.8
Height	0.7	12.8	20.7	2.5	4.5	3.1	4.2	4.2	3.0	2.9
Maternal smoking around birth	0.7	1.0	2.6	1.0	-0.7	1.4	-0.5	-0.2	1.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	-0.1	-1.2	-1.1	-1.2	-1.1	-1.0	-0.6
Pain all over the body in last month	0.7	0.8	1.4	0.8	1.2	-0.5	1.1	1.2	-0.7	0.0
Noisy workplace	0.7	0.8	1.6	0.9	1.3	0.6	1.2	1.1	0.6	-0.4
Birth weight of first child	0.7	1.3	3.1	-0.1	-0.1	1.8	-0.4	-0.2	1.7	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	4.0	0.6	-0.1	0.4	-0.4	-0.3	0.4	2.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.7	1.7	0.8	-1.1	0.9	0.9	-1.1	-0.3
Osteoporosis (self-reported)	0.7	0.9	2.3	1.5	1.3	0.6	0.8	0.7	1.0	-0.2
Supplements: Calcium	0.7	0.8	1.6	0.9	1.2	-0.4	1.3	1.1	-0.2	0.2
Bipolar Disorder (2018)	0.6	1.0	2.1	1.4	-0.8	1.2	-0.9	-0.8	1.1	-0.0
Depression (Nagel 2018)	0.6	0.9	2.2	0.3	-1.3	-0.5	-1.5	-1.3	-0.4	-0.2
Ovarian Cancer	0.6	0.8	1.1	-1.0	-0.8	-0.8	-1.0	-0.7	-0.8	-0.8
Age at First Birth	0.6	0.8	2.9	0.0	0.1	1.5	0.0	0.0	1.7	-0.8
HDL Cholesterol	0.6	0.9	3.0	0.2	0.8	1.4	0.4	0.4	1.7	0.7
Hypothyroidism (self reported)	0.6	1.4	2.9	0.8	-1.4	-1.1	-1.7	-1.4	-0.8	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	0.6	1.1	-0.3	1.1	1.2	-0.3	-1.0
Supplements: Zinc	0.6	0.7	3.1	-1.0	-0.4	-0.2	-0.3	-0.5	-0.0	-1.8
Impedance of leg (right)	0.6	2.8	6.4	1.6	2.0	-0.6	2.5	2.5	-0.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-1.1	-0.6	0.6	-0.9	-1.0	0.3	-1.1
Fluid intelligence score	0.6	1.2	3.3	0.7	-0.3	1.8	-0.5	-0.2	1.8	1.0
Time employed in main current job	0.6	0.7	2.8	1.7	0.7	-0.1	0.7	0.5	0.0	0.9
Father’s age at death	0.6	0.8	2.2	-0.9	-0.5	0.9	-0.4	-0.5	1.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	1.1	0.1	-1.3	0.3	0.7	-1.3	-1.2
Hair/balding pattern: Pattern 3	0.6	0.9	3.1	-0.3	-0.9	0.5	-1.1	-0.8	0.7	-1.7
Tense / ‘highly strung’	0.6	0.9	4.1	2.0	0.2	-0.1	0.2	0.2	-0.1	-1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	0.1	-1.1	-1.1	-0.8	-0.9	-1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.3	-0.4	-0.4	1.3	-0.4	-0.6	1.5	-0.2
Suffer from ‘nerves’	0.6	1.0	1.7	0.4	-1.1	1.0	-1.2	-1.0	0.8	-1.3
Knee pain experienced in last month	0.6	0.9	2.2	0.4	0.8	-1.5	0.7	0.8	-1.4	-0.6
Breast cancer (self-reported)	0.6	0.7	1.9	-0.2	-0.9	0.5	-1.3	-1.4	-0.1	-0.5
Smoking status: Current	0.6	1.0	2.9	1.7	0.9	-1.1	0.9	0.7	-1.0	0.0
Basal metabolic rate	0.6	3.5	8.8	-3.0	-2.2	0.3	-2.4	-2.2	0.3	-0.4
Leg fat percentage (left)	0.6	2.0	2.8	-1.3	-1.6	-1.7	-1.6	-1.4	-1.5	0.5
Number of operations (self-reported)	0.6	0.8	1.8	-0.8	-0.8	1.3	-0.7	-0.9	1.2	-0.1
Fractured/broken bones in last 5 years	0.6	0.7	1.9	0.3	1.1	-0.5	1.4	1.2	-0.5	0.1
Pain experienced in last month	0.6	1.0	1.7	-1.0	-0.9	0.9	-0.9	-1.0	1.0	1.3
Alcohol drinker status: Previous	0.6	0.6	1.3	1.2	1.1	-0.3	0.8	0.9	-0.2	0.5
Major Depression (MDD)	0.5	0.6	1.0	0.5	-0.7	0.8	-0.8	-0.8	1.0	-0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.2	0.5	-0.3	1.7	-0.2	-0.0	1.6	1.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.0	-1.7	-0.7	-0.6	-0.9	-0.6	-0.6	-0.8
Medication: Metformin	0.5	0.7	1.7	-1.1	-0.3	-1.3	-0.6	-0.4	-1.2	-0.1
Diabetes (father)	0.5	0.7	2.3	-0.8	0.1	-1.2	-0.1	-0.0	-1.5	-0.5
Current tobacco smoking	0.5	0.8	2.0	1.4	0.6	-1.1	0.6	0.4	-1.1	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.5	1.2	0.6	1.0	1.0	0.4	-0.4
Had menopause	0.5	0.6	1.2	-0.2	-0.7	-0.5	-1.0	-1.1	-0.8	0.7
Had other major operations	0.5	0.7	2.9	0.1	-0.4	0.5	-0.7	-0.8	0.1	1.7
Mouth/teeth dental problems	0.5	0.7	1.7	-1.3	-1.1	0.6	-0.8	-0.8	0.5	0.4
Heart attack	0.5	0.6	1.1	0.7	0.9	-0.5	0.9	0.9	-0.3	1.1
Arm fat percentage (right)	0.5	1.8	3.0	0.6	1.3	-1.7	1.0	1.2	-1.7	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.7	-2.2	-1.5	-0.4	-1.6	-1.3	-0.5	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	1.5	0.4	0.9	0.2	0.2	1.0	0.5
Standing height	0.5	4.6	8.0	0.6	2.8	2.0	2.8	2.8	1.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.2	-0.0	0.3	-0.6	1.0	1.0	-0.8	-1.5
Pulse wave reflection index	0.5	0.6	1.3	0.7	-0.6	-1.2	-0.3	-0.2	-1.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-1.0	-1.3	-0.6	-0.7	-0.7	-0.4	-1.2
Glaucoma (self-reported)	0.5	0.6	1.9	-0.4	-0.4	-1.4	-0.4	-0.4	-1.4	0.1
Body fat percentage	0.5	2.1	3.1	0.7	1.4	-1.8	1.2	1.3	-1.7	1.7
Pulse wave peak to peak time	0.5	0.5	2.3	-1.5	-0.3	-0.7	-0.1	-0.2	-0.8	-0.5
Qualifications: College or University degree	0.5	1.6	5.0	0.8	0.1	2.1	0.0	0.0	2.2	1.0
Eye problems/disorders: None of the above	0.5	0.5	0.6	0.6	0.8	-0.8	0.7	0.8	-0.8	0.7
Emphysema/chronic bronchitis	0.5	0.5	1.0	1.0	0.6	-0.5	0.8	0.8	-0.5	-0.8
Neck or shoulder pain in last month	0.5	0.7	3.1	1.8	0.7	-0.4	0.6	0.4	-0.5	0.2
Leg pain on walking	0.5	0.6	1.4	1.0	1.2	0.1	0.9	0.9	0.2	-0.0
Illnesses of father: Heart disease	0.5	0.6	2.4	1.5	0.6	-0.6	0.3	0.3	-0.8	0.8
Arm fat percentage (left)	0.5	1.8	3.3	0.5	1.1	-1.8	0.9	1.1	-1.8	1.6
Back pain experienced in last month	0.5	0.7	2.4	0.5	-0.1	-1.4	-0.4	-0.3	-1.5	-0.5
Mother’s age at death	0.5	0.7	2.7	-1.6	-0.7	0.6	-0.6	-0.7	0.6	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	-0.4	-0.8	-0.8	-0.9	-0.9	-0.8	0.6
Myopia	0.5	0.7	1.2	-0.8	-0.9	0.2	-1.0	-1.0	0.3	-1.1
Leg fat mass (left)	0.5	1.8	3.2	-1.8	-1.3	-1.4	-1.5	-1.2	-1.4	0.5
Alzheimer’s Disease (in mother)	0.4	0.4	2.1	-1.5	0.0	0.3	0.1	0.1	0.1	0.8
Crohns Disease (2017)	0.4	0.8	1.8	0.9	0.8	0.1	1.3	1.2	0.3	-1.0
Fasting Glucose	0.4	0.5	1.2	0.5	0.6	-0.8	1.1	1.0	-0.3	0.5
Primary Biliary Cirrhosis	0.4	0.5	1.4	0.4	-0.2	1.2	-0.2	-0.1	1.0	-1.1
Vitamin and mineral supplements	0.4	0.6	1.2	-1.1	-0.7	-0.9	-0.6	-0.6	-0.6	0.6
Severe depression (siblings)	0.4	0.5	1.1	0.4	1.0	-0.6	0.8	0.9	-0.6	-0.2
Relative age voice broke	0.4	0.7	1.2	1.1	1.0	0.2	1.0	0.8	-0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.3	-1.1	-0.7	-0.1	-0.4	-0.5	0.1	-0.9
Medication: Levothyroxine sodium	0.4	0.7	1.2	0.9	-0.9	-0.4	-1.1	-1.0	-0.1	1.0
Impedance of leg (left)	0.4	1.9	4.3	1.6	1.5	-0.5	2.1	2.0	-0.4	0.2
Past tobacco smoking	0.4	0.7	2.2	-0.5	-1.5	0.5	-1.0	-1.0	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	0.9	-0.9	0.1	-1.1	-1.0	0.0	0.2
Diabetes (self-reported)	0.4	0.6	1.1	-0.9	-0.2	-1.0	-0.5	-0.3	-1.0	-1.1
Illnesses of siblings	0.4	0.6	2.6	-1.6	-0.6	-0.0	-0.2	-0.2	0.0	-1.0
Falls in the last year	0.4	0.5	1.7	1.3	0.2	-0.9	0.1	-0.1	-1.0	-0.2
Mouth/teeth dental problems: Dentures	0.4	0.6	3.8	-0.6	0.2	0.3	-0.1	-0.1	0.3	-2.0
Medication: Cholesterol lowering	0.4	0.6	2.0	-0.9	-0.5	-0.6	-0.6	-0.5	-0.6	-1.4
Headache pain in last month	0.4	0.6	2.5	1.6	-0.2	0.8	0.3	0.1	1.0	0.4
High blood pressure (siblings)	0.4	0.6	0.9	0.6	1.0	0.9	0.8	0.8	0.9	0.3
Leg fat percentage (right)	0.4	1.6	3.1	-1.2	-1.1	-1.8	-1.2	-1.0	-1.6	0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	1.2	0.8	-0.6	0.6	0.5	-0.5	-0.1
Leg fat mass (right)	0.4	1.4	2.7	-1.6	-1.1	-1.3	-1.2	-0.9	-1.2	0.5
Mood swings	0.4	0.7	1.6	0.0	-1.0	-0.4	-1.3	-1.2	-0.3	-0.9
Average weekly champagne plus white wine intake	0.4	0.6	0.9	-0.9	0.7	-0.4	0.9	0.9	-0.3	-0.7
Financial situation satisfaction	0.4	0.5	2.4	1.6	0.2	0.5	-0.1	0.3	0.3	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.3	-0.3	-0.6	-0.2	-0.2	-0.7	-0.3	-1.5
Intelligence (Savage-Jansen 2018)	0.3	1.1	2.1	0.8	1.2	0.3	1.2	1.3	0.1	1.5
Breast Cancer	0.3	0.8	2.0	0.6	1.4	0.2	1.2	1.3	0.3	-0.4
Lung FVC	0.3	1.3	3.6	1.9	1.0	1.1	0.8	1.0	1.1	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	1.2	-1.1	0.1	0.7	0.2	0.2	0.8	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.5	-0.7	0.2	-0.8	-0.8	0.2	-0.0
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.4	-0.8	0.8	-0.6	-0.7	0.6	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	0.3	0.5	0.9	0.5	0.6	0.8	0.2
Trunk fat mass	0.3	1.4	2.7	0.1	1.3	-1.3	1.0	1.2	-1.2	1.6
Nervous feelings	0.3	0.5	2.1	0.9	-0.5	0.6	-0.4	-0.3	0.3	-1.4
Hearing difficulty/problems with background noise	0.3	0.4	2.4	1.6	0.1	0.6	0.3	-0.0	0.5	0.1
Medication: Simvastatin	0.3	0.4	1.1	-0.6	0.5	-0.7	0.3	0.3	-0.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.0	-0.5	-0.7	-0.2	-0.6	-0.6	-0.3	-1.0
Loud music exposure frequency	0.3	0.3	1.0	0.3	0.6	-0.1	1.0	0.9	-0.1	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.4	-0.0	0.4	1.2	0.5	0.5	1.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.6	1.3	-0.4	-0.7	-0.8	-0.6	-0.5	1.1
Medication: Blood pressure	0.3	0.4	1.3	0.6	0.1	-1.2	0.0	-0.1	-1.1	-0.5
Smoking status: Previous	0.3	0.4	1.4	0.1	1.2	-0.1	0.8	0.9	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.2	-0.4	-1.1	0.6	-0.8	-0.8	0.8	-0.1
Average weekly red wine intake	0.3	0.5	0.8	-0.9	-0.1	-0.9	-0.4	-0.3	-0.9	-0.9
Ever had bowel cancer screening	0.3	0.3	0.7	-0.3	0.8	0.4	0.3	0.3	0.6	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	1.0	-1.0	0.2	-0.2	0.4	0.4	-0.1	-1.0
Alcohol drinker status: Never	0.3	0.3	0.8	0.1	-0.2	-0.8	-0.5	-0.5	-0.9	0.5
Ever smoked	0.3	0.5	1.0	0.4	1.0	-0.8	0.6	0.7	-0.7	-0.4
Unable to work because of sickness or disability	0.3	0.3	0.5	0.4	0.7	0.3	0.6	0.7	0.6	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	-0.0	-0.7	0.4	0.2	-0.8	-0.9
Prostate Cancer	0.2	0.2	0.6	-0.1	0.8	0.3	0.5	0.4	0.6	-0.5
Crohns Disease (2012)	0.2	0.3	0.9	0.2	0.5	-0.2	0.9	0.9	-0.1	-0.1
Blood Eosinophil Count	0.2	1.3	3.5	0.6	0.1	-1.9	0.2	0.2	-1.6	1.6
Average weekly spirits intake	0.2	0.3	0.9	-0.0	0.8	-0.3	0.2	0.4	-0.5	-0.9
Medication: Co-codamol	0.2	0.3	1.0	0.4	0.5	0.1	0.5	0.5	0.1	-1.0
Diabetes (mother)	0.2	0.3	1.3	-0.1	0.3	0.5	0.3	0.4	0.5	1.1
Multivitamins +/- minerals	0.2	0.2	0.8	0.9	0.4	0.4	0.4	0.4	0.1	-0.4
Supplements: Glucosamine	0.2	0.3	0.6	-0.4	-0.2	0.3	-0.8	-0.8	0.5	0.7
Waist circumference	0.2	0.9	2.1	-0.2	0.1	-1.4	-0.5	-0.2	-1.4	1.4
Qualifications: None of the above	0.2	0.4	1.3	0.2	0.9	0.2	0.5	0.5	0.4	-1.1
Medication: Ramipril	0.2	0.3	0.5	-0.7	-0.4	-0.7	-0.5	-0.4	-0.7	0.1
Weight	0.2	1.1	2.9	-1.7	-0.9	-0.6	-1.2	-1.0	-0.6	0.9
Hip circumference	0.2	0.9	2.4	-1.6	-0.8	-0.6	-1.1	-0.9	-0.8	0.8
Alcohol intake versus 10 years previously	0.2	0.2	0.9	0.4	0.4	-0.2	-0.3	-0.3	-0.5	1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.8	-0.9	0.0	-0.6	-0.6	0.1	-0.8
Arm fat mass (right)	0.2	1.0	2.1	-1.1	-0.4	-1.4	-0.7	-0.5	-1.4	1.0
Breastfed as a baby	0.2	0.3	1.2	-1.1	-0.2	0.0	0.0	0.0	-0.1	-0.8
Blood clot in the leg (DVT)	0.2	0.3	1.5	1.2	0.3	-0.1	-0.1	0.1	-0.4	0.7
Exposure to tobacco smoke outside home	0.2	0.2	1.4	1.2	-0.0	0.2	-0.3	-0.1	0.4	-0.2
Health satisfaction	0.2	0.3	0.7	0.9	-0.1	-0.7	-0.2	-0.1	-0.7	-0.4
Whole body fat mass	0.2	0.8	1.9	-0.4	0.4	-1.4	0.2	0.4	-1.3	1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.4	-0.7	0.6	-0.6	-0.5	0.7	-0.0
Leg fat-free mass (right)	0.2	0.9	2.3	-1.5	-0.8	0.7	-1.1	-0.9	0.5	0.7
Qualifications: nursing, teaching	0.2	0.4	0.9	-0.8	-0.2	-0.5	-0.7	-0.5	-0.3	1.0
Mineral and other dietary supplements	0.2	0.3	0.6	-0.7	-0.8	0.5	-0.6	-0.5	0.6	0.1
Leg predicted mass (right)	0.2	0.9	2.3	-1.5	-0.8	0.7	-1.1	-0.9	0.5	0.7
Arm fat mass (left)	0.2	1.0	1.8	-1.1	-0.6	-1.4	-0.8	-0.5	-1.3	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.0	0.5	-0.4	0.6	0.5	-0.8	-0.5
Medication: Paracetamol	0.2	0.4	0.5	0.7	0.4	-0.7	0.7	0.6	-0.7	0.4
Medication: Lisinopril	0.2	0.2	0.7	-0.2	0.1	-0.8	0.2	0.2	-0.8	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.2	0.5	-0.4	0.6	0.6	-0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.0	1.0	0.2	-0.3	-0.1	0.1	-0.6	0.3
Mean Putamen Volume	0.1	0.1	0.2	0.2	0.3	0.1	0.4	0.2	0.1	0.4
Blood White Count	0.1	0.4	0.7	0.7	0.5	0.8	0.5	0.4	0.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.9	0.1	0.2	-0.1	-0.1	-0.1	-0.1	1.0
Leg fat-free mass (left)	0.1	0.6	2.0	-1.4	-0.5	0.6	-0.8	-0.6	0.5	0.6
Sitting height	0.1	0.8	1.5	0.2	0.9	0.6	1.1	1.1	0.6	1.2
Leg predicted mass (left)	0.1	0.6	2.1	-1.4	-0.5	0.6	-0.8	-0.6	0.4	0.6
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.5	0.1	0.8	-0.0	0.3	0.7	-0.3
Depression (self-reported)	0.1	0.1	0.5	0.3	-0.1	0.7	-0.0	-0.0	0.5	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.1	0.7	0.7	0.5	0.9	0.6	0.5
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.0	0.4	-0.1	-0.1	0.2	-0.5
Medication: Omeprazole	0.1	0.1	0.8	-0.2	-0.2	-0.2	0.3	-0.2	-0.2	-0.9
Alcohol intake frequency.	0.1	0.3	0.6	-0.2	-0.5	-0.2	-0.8	-0.8	-0.2	-0.8
Comparative height size at age 10	0.1	0.4	0.5	-0.6	0.6	-0.7	0.7	0.6	-0.6	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.1	-0.2	-0.5	-0.2	-0.2	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	-0.2	0.6	-0.0	0.6	0.5	0.1	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.0	0.3	-0.5	0.2	0.3	-0.5	0.4
Medication: Paracetamol	0.0	0.0	0.2	0.3	-0.4	-0.1	0.0	0.0	-0.1	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.2	0.3	-0.1	0.0	0.0	-0.0	0.1
Age at first live birth	0.0	0.1	0.1	0.3	0.1	0.2	0.3	0.2	0.3	0.2

Hub : Genes

USP35

Models

Trait associations