Best TWAS P=1.97e-13 · Best GWAS P=4.64e-11 conditioned to 0.000741
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | DCAF4 | 0.20 | 0.05 | lasso | 7 | 0.18 | 1.1e-14 | -4.9 | -5.3 | 9.7e-08 | 0.57 | 0.74 | 0.26 | FALSE |
2 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | -4.6 | -6.2 | 4.3e-10 | 0.53 | 0.32 | 0.64 | FALSE |
3 | GTEx | Breast Mammary Tissue | DCAF4 | 0.24 | 0.10 | lasso | 6 | 0.18 | 1.2e-09 | -4.9 | -6.8 | 1.1e-11 | 0.53 | 0.69 | 0.25 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | DCAF4 | 0.16 | 0.07 | lasso | 4 | 0.03 | 4.4e-02 | 5.4 | -5.9 | 3.0e-09 | 0.35 | 0.08 | 0.30 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | RP11-109N23.6 | 0.18 | -0.01 | lasso | 7 | 0.00 | 3.9e-01 | 3.9 | -5.3 | 1.3e-07 | 0.37 | 0.11 | 0.19 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | DPF3 | 0.39 | 0.40 | lasso | 4 | 0.39 | 9.6e-31 | -5.2 | -5.5 | 4.0e-08 | 0.04 | 0.66 | 0.34 | FALSE |
7 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | -5.5 | -6.5 | 1.0e-10 | 0.58 | 0.11 | 0.37 | FALSE |
8 | GTEx | Colon Transverse | DCAF4 | 0.26 | 0.27 | lasso | 10 | 0.27 | 2.7e-13 | -4.9 | -5.7 | 1.2e-08 | 0.61 | 0.92 | 0.08 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | -5.5 | -6.9 | 5.1e-12 | 0.52 | 0.09 | 0.38 | FALSE |
10 | GTEx | Esophagus Mucosa | DCAF4 | 0.30 | 0.19 | enet | 35 | 0.23 | 1.3e-15 | -5.5 | -6.0 | 2.1e-09 | 0.51 | 0.52 | 0.48 | FALSE |
11 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | -5.5 | -7.0 | 1.8e-12 | 0.66 | 0.18 | 0.41 | FALSE |
12 | GTEx | Lung | DCAF4 | 0.32 | 0.15 | lasso | 8 | 0.25 | 5.6e-19 | -5.5 | -5.2 | 1.7e-07 | 0.55 | 0.61 | 0.39 | FALSE |
13 | GTEx | Pancreas | DCAF4 | 0.20 | 0.15 | lasso | 4 | 0.14 | 2.4e-06 | -5.5 | -5.5 | 4.6e-08 | 0.51 | 0.36 | 0.31 | FALSE |
14 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | -4.9 | -7.3 | 3.8e-13 | 0.58 | 0.10 | 0.86 | FALSE |
15 | GTEx | Spleen | NUMB | 0.46 | -0.01 | enet | 28 | 0.09 | 3.2e-03 | -2.0 | -5.5 | 2.9e-08 | 0.51 | 0.06 | 0.47 | FALSE |
16 | GTEx | Stomach | DCAF4 | 0.22 | 0.07 | enet | 27 | 0.14 | 4.7e-07 | -5.5 | -5.2 | 2.0e-07 | 0.55 | 0.24 | 0.53 | FALSE |
17 | METSIM | Adipose | DCAF4 | 0.21 | 0.15 | bslmm | 452 | 0.21 | 3.0e-30 | -4.9 | -5.1 | 3.1e-07 | 0.48 | 0.93 | 0.07 | FALSE |
18 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | -5.5 | -5.8 | 5.6e-09 | 0.58 | 0.52 | 0.48 | FALSE |
19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCAF4 | 0.04 | 0.02 | blup | 83 | 0.03 | 1.2e-04 | -4.5 | -6.1 | 9.9e-10 | 0.75 | 0.14 | 0.72 | FALSE |
20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF3 | 0.18 | 0.18 | lasso | 7 | 0.22 | 1.6e-24 | -4.9 | -5.9 | 3.7e-09 | 0.48 | 0.43 | 0.57 | FALSE |
21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF4 | 0.26 | 0.09 | enet | 13 | 0.13 | 2.1e-14 | -4.9 | -5.3 | 1.1e-07 | 0.38 | 0.68 | 0.32 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | 4.7 | 7.3 | 2.0e-13 | -0.50 | 0.50 | 0.46 | TRUE |