TWAS hub - UBE4B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0860	0.0380	8.9e-03	-0.003	NA	0.004	NA	-0.001	0.7900	NA	1.4e-01	NA	3.6e-01
2	YFS	Blood	0.0273	0.0102	6.3e-05	0.006	0.016	0.013	0.016	0.014	0.0026	4e-06	3.4e-05	3.1e-06	1.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Breast Cancer	6.8	16.4	29.1	5.4	-1.9
Hand grip strength (right)	5.7	15.5	20.1	3.3	-4.5
Asthma (self-reported)	5.3	10.6	16.2	-4.0	2.3
Heart attack	5.1	6.5	10.7	-3.3	-1.5
Allergy	5.0	11.4	18.4	4.3	-2.1
Ever had prostate specific antigen (PSA) test	5.0	5.7	11.4	-3.4	0.0
Asthma	4.8	9.4	11.8	-3.4	2.6
Alcohol intake versus 10 years previously	4.2	6.3	6.7	2.6	2.4
Hand grip strength (left)	4.1	10.8	15.4	2.5	-3.9
Type 2 Diabetes (T2D) (2012)	4.0	4.6	8.9	3.0	0.6
Mean Putamen Volume	3.9	4.4	7.2	-2.7	1.3
Heart attack/myocardial infarction (self-reported)	3.9	5.1	8.3	-2.9	-1.4
Prostate Cancer	3.8	5.3	5.4	-2.3	2.3
Impedance of arm (left)	3.8	17.6	35.0	-5.9	0.3
Medication: Levothyroxine sodium	3.7	6.3	11.8	-3.4	-0.9
Impedance of arm (right)	3.7	17.3	34.5	-5.9	0.3
Hearing aid user	3.7	4.1	8.1	-2.9	0.4
Standing height	3.6	35.3	51.1	-4.4	-7.2
Medication: Ventolin 100micrograms inhaler	3.6	4.6	7.0	-1.5	2.6
Forced vital capacity (FVC), Best measure	3.5	12.7	24.3	-1.0	-4.9
Respiratory disease	3.4	7.5	11.9	-3.5	1.7
Other serious medical condition/disability diagnosed by doctor	3.4	4.4	8.4	0.7	2.9
Medication: Seretide 50 evohaler	3.4	3.9	6.8	1.0	2.6
Height	3.2	60.7	82.3	-6.3	-9.1
Falls in the last year	3.2	4.4	5.5	2.3	1.8
Hypothyroidism (self reported)	3.1	7.1	14.0	-3.7	-0.5
Hayfever, allergic rhinitis or eczema	3.1	6.7	9.9	-3.1	1.9
Chronic bronchitis/emphysema (father)	3.1	3.7	6.0	-2.4	1.2
Age started oral contraceptive pill	3.1	3.9	6.2	-1.3	-2.5
Impedance of whole body	3.1	15.5	31.0	-5.6	0.1
Forced vital capacity (FVC)	3.0	11.5	20.7	-1.5	-4.5
Hypothyroidism/myxoedema (self-reported)	3.0	5.9	11.8	-3.4	-0.0
Allergy or Eczema	2.9	7.6	9.9	-3.1	2.3
Medication: Metformin	2.9	4.1	8.1	0.3	2.8
Pain all over the body in last month	2.9	3.2	5.2	-1.0	2.3
Comparative height size at age 10	2.9	16.0	22.2	-4.7	-3.1
Risk taking	2.9	4.2	4.9	2.2	1.9
Blood White Count	2.8	20.5	36.7	-2.1	6.1
High blood pressure (mother)	2.8	3.9	5.4	1.6	2.3
Commuting to job workplace: Cycle	2.7	3.2	4.6	1.3	2.1
Alcohol usually taken with meals	2.6	4.2	6.4	-1.4	-2.5
High blood pressure (siblings)	2.6	3.8	5.1	2.3	1.6
Had major operations	2.6	3.0	5.3	-2.3	-0.9
Reaction Time	2.5	4.7	5.2	-2.3	-2.0
Long-standing illness, disability or infirmity	2.5	3.8	7.3	-0.5	2.7
Relative age of first facial hair	2.4	5.0	6.3	1.9	-2.5
Hearing difficulty/problems with background noise	2.4	3.8	6.4	1.1	2.5
Noisy workplace	2.4	3.0	5.0	-2.2	-1.0
Exposure to tobacco smoke at home	2.4	2.6	5.3	2.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	9.1	-1.0	-3.0
Diabetes diagnosed by doctor	2.4	3.9	7.7	0.3	2.8
Heel T-Score	2.3	18.4	34.7	-5.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	4.8	-1.2	2.2
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.7	1.0	2.2
Hair/balding pattern: Pattern 4	2.3	5.7	9.9	-1.2	3.1
Health satisfaction	2.3	3.0	3.5	1.6	1.9
Breast cancer (self-reported)	2.3	2.8	5.4	-2.3	-0.4
Supplements: Fish oil (including cod liver oil)	2.3	3.1	5.7	-2.4	-0.7
Illnesses of father: High blood pressure	2.3	2.9	3.6	1.5	1.9
Average weekly spirits intake	2.2	2.7	5.0	-0.7	2.2
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	3.8	-1.4	-2.0
Wheeze or whistling in the chest in last year	2.2	3.8	5.1	-2.2	1.6
Sitting height	2.1	14.6	28.2	-1.0	-5.3
Trunk predicted mass	2.1	11.7	22.4	1.1	-4.7
Arm predicted mass (right)	2.1	10.6	21.1	0.5	-4.6
Diabetes (mother)	2.0	2.6	3.0	1.5	1.7
Trunk fat-free mass	2.0	11.6	22.1	1.0	-4.7
Birth weight of first child	2.0	3.6	5.6	-2.4	-1.3
Chest pain or discomfort	2.0	2.8	5.7	-0.0	2.4
Number of self-reported non-cancer illnesses	2.0	3.5	4.1	-2.0	1.7
Lupus	1.9	2.9	5.8	-2.4	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.2	0.2	2.3
High blood pressure	1.9	5.4	6.9	2.0	2.6
Forced expiratory volume in 1-second (FEV1)	1.9	6.4	12.7	-0.4	-3.6
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.4	1.8	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	12.1	-0.2	-3.5
Arm fat-free mass (right)	1.9	9.7	19.0	0.6	-4.4
Family relationship satisfaction	1.9	2.4	2.9	1.4	1.7
Whole body fat-free mass	1.9	10.9	21.7	0.3	-4.7
Medication for cholesterol	1.9	2.9	5.6	-0.5	-2.4
LDL Cholesterol	1.8	2.8	5.6	-2.4	-0.1
Cardiovascular Disease	1.8	6.0	9.7	1.6	3.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	3.3	1.8	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	5.4	-0.6	2.3
Overall health rating	1.8	3.8	7.1	0.7	2.7
Qualifications: nursing, teaching	1.8	2.9	5.1	-2.3	-0.8
Whole body water mass	1.8	10.4	20.7	0.4	-4.5
Arm predicted mass (left)	1.8	9.0	16.6	1.2	-4.1
Medication: Co-codamol	1.7	2.0	3.5	-1.9	-0.7
Age when periods started (menarche)	1.7	4.2	6.4	-1.4	-2.5
Supplements: Glucosamine	1.7	2.2	2.5	-1.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	4.0	2.0	0.4
Loud music exposure frequency	1.7	1.9	3.8	0.1	1.9
Supplements: Vitamin C	1.7	2.0	3.1	-1.8	1.0
Hypertension (Self-reported)	1.7	4.7	6.0	1.8	2.5
Medication: Bendroflumethiazide	1.7	2.5	4.2	2.0	0.9
Medication: Lisinopril	1.7	2.2	2.2	1.5	1.5
Ever depressed for a whole week	1.7	2.1	3.5	0.9	1.9
Vascular/heart problems diagnosed by doctor	1.7	4.5	7.0	-1.4	-2.6
Waist Hip Ratio (WHR)	1.6	7.3	14.4	-0.3	3.8
Leg fat-free mass (left)	1.6	8.4	16.5	-0.6	-4.1
Trunk fat percentage	1.6	6.4	12.6	-3.6	-0.3
Taking other prescription medications	1.6	2.5	4.7	-2.2	0.6
Leg fat-free mass (right)	1.6	8.4	16.3	-0.7	-4.0
Osteoporosis (self-reported)	1.6	2.0	3.0	1.0	1.7
Basal metabolic rate	1.6	8.8	17.6	0.0	-4.2
Arm fat-free mass (left)	1.6	8.3	15.4	1.1	-3.9
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.7	-1.9	-0.3
Type 2 Diabetes (T2D) (2018)	1.5	2.8	5.2	0.7	2.3
Leg predicted mass (left)	1.5	8.0	15.8	-0.5	-4.0
Diabetes (self-reported)	1.5	2.4	4.3	0.7	2.1
Mineral and other dietary supplements	1.5	2.0	3.0	1.7	1.0
Leg predicted mass (right)	1.5	8.0	15.8	-0.6	-4.0
Birth weight	1.4	3.0	3.6	-1.5	-1.9
Osteoarthritis (self-reported)	1.4	1.8	3.5	-1.9	-0.3
Bipolar Disorder (2018)	1.3	2.0	3.0	-1.7	-1.0
Maternal smoking around birth	1.3	1.9	3.8	0.0	-1.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	1.7	-1.3	1.3
Hip circumference	1.3	5.4	6.1	-2.2	-2.5
Qualifications: A levels/AS levels or equivalent	1.3	2.9	5.4	0.6	2.3
Shortness of breath walking on level ground	1.3	1.5	2.8	0.5	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	1.9	1.1	1.4
Smoking status: Previous	1.3	2.0	3.8	-1.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	1.7	-1.3	1.2
Average weekly champagne plus white wine intake	1.3	1.8	2.0	-1.3	-1.4
High cholesterol (Self-reported)	1.3	2.4	2.5	-1.5	1.6
Cholesterol lowering medication	1.3	1.9	3.6	0.4	1.9
Depression (Nagel 2018)	1.2	1.8	3.6	-0.3	1.9
Supplements: Zinc	1.2	1.3	2.5	0.4	1.6
Impedance of leg (left)	1.2	6.0	11.6	-3.4	0.6
Trunk fat mass	1.2	5.0	8.2	-2.9	-1.4
Financial difficulties in last 2 years	1.1	1.4	2.9	1.7	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.8	-0.1	-1.9
Number of children fathered	1.1	1.2	1.8	0.7	1.4
Medication: Ibuprofen	1.1	1.3	2.6	1.6	0.1
Knee pain experienced in last month	1.1	1.7	2.4	1.0	1.5
Medication: Atorvastatin	1.1	1.4	2.6	-1.6	0.3
Fractured/broken bones in last 5 years	1.1	1.5	2.3	-0.8	-1.5
Supplements: Calcium	1.1	1.2	1.2	-1.1	-1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	-0.0	1.6
Major Depression (MDD)	1.0	1.2	1.5	0.9	1.2
Lung FVC	1.0	4.9	6.3	1.9	-2.5
Hearing difficulty/problems: Yes	1.0	1.5	3.0	0.1	1.7
Vitamin and mineral supplements	1.0	1.3	1.5	1.1	-1.2
Impedance of leg (right)	1.0	4.7	9.2	-3.0	0.5
Townsend deprivation index at recruitment	1.0	1.4	2.1	-1.4	-0.9
Serious illness, injury or assault to yourself	1.0	1.2	1.9	0.8	1.4
Multivitamins +/- minerals	1.0	1.2	2.1	0.6	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	1.8	-0.7	1.3
Medication: Simvastatin	1.0	1.4	2.7	0.3	1.6
Pulse rate	1.0	1.7	3.1	-0.5	-1.8
Pulse wave Arterial Stiffness index	1.0	1.2	1.6	-1.2	-0.9
Migraine (self-reported)	1.0	1.3	1.5	-1.2	-1.0
Medication: Aspirin	1.0	1.3	2.6	-1.6	0.2
Ever taken oral contraceptive pill	1.0	1.1	1.2	1.1	1.0
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	1.6	0.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.3	-1.1	0.9
Qualifications: CSEs or equivalent	0.9	1.2	2.1	0.6	-1.4
Had other major operations	0.9	1.1	2.1	-0.2	1.5
Body fat percentage	0.9	3.6	7.1	-2.7	0.2
Neck or shoulder pain in last month	0.9	1.3	2.6	0.1	1.6
Mean time to correctly identify matches	0.9	1.8	2.6	-1.6	-1.0
Medication: Aspirin	0.9	1.2	2.4	-1.6	0.2
Medication: Gliclazide	0.9	1.0	2.0	-0.1	1.4
Average weekly beer plus cider intake	0.9	1.4	2.7	1.6	0.1
Unable to work because of sickness or disability	0.9	1.1	2.0	0.5	1.4
Illnesses of siblings	0.8	1.1	1.8	-1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.2	-1.5	0.4
Peak expiratory flow (PEF)	0.8	1.8	2.0	1.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.7	1.0	1.3
Medication: Blood pressure	0.8	1.5	2.7	0.5	1.6
Alcohol intake frequency.	0.8	1.9	2.0	1.4	1.4
Suffer from ‘nerves’	0.8	1.3	2.1	0.7	1.5
Guilty feelings	0.8	1.3	1.8	-0.8	1.4
Alcohol drinker status: Previous	0.8	1.0	1.8	-1.4	0.3
Bipolar Disorder (2011)	0.7	0.7	1.1	0.5	1.0
Coronary Artery Disease (CAD)	0.7	0.8	1.6	1.3	0.2
HDL Cholesterol	0.7	1.1	2.1	-1.4	0.3
Lung FEV1/FVC ratio	0.7	3.7	4.2	2.1	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.1	-1.8	-0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	-1.2	0.2
Mouth/teeth dental problems	0.7	1.1	2.2	-0.1	1.5
Fluid intelligence score	0.7	1.4	2.9	1.7	0.1
Weight	0.7	3.5	6.1	-1.0	-2.5
Hair/balding pattern: Pattern 3	0.7	1.0	2.0	-0.0	1.4
Medication: Cholesterol lowering	0.7	1.1	1.2	-1.1	1.0
Prospective memory result	0.7	0.9	1.6	-1.3	0.5
Age at last live birth	0.7	1.0	2.0	-0.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.3	-1.1	-0.6
Commuting to job workplace: Walk	0.7	0.8	1.4	0.5	-1.2
Diastolic blood pressure, automated reading	0.7	2.1	2.7	1.6	1.2
Bipolar Disorder or Schizophrenia	0.6	1.6	3.1	-1.8	-0.3
Ulcerative Colitis (UC)	0.6	1.0	1.1	-1.0	-1.1
Ovarian Cancer	0.6	0.7	1.0	-0.7	-1.0
Ulcerative Colitis	0.6	0.8	1.2	-0.7	-1.1
BMI	0.6	3.4	4.5	2.1	1.6
Systolic Blood Pressure	0.6	2.8	2.9	1.7	1.6
Fed-up feelings	0.6	1.0	2.0	1.4	0.3
Number of live births	0.6	0.9	1.2	-1.1	-0.7
Length of working week for main job	0.6	0.7	1.0	-1.0	-0.7
Exposure to tobacco smoke outside home	0.6	0.8	1.7	1.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	-1.2	-0.1
Medication: Omeprazole	0.6	0.7	1.3	-1.1	-0.3
Whole body fat mass	0.6	2.5	4.3	-2.1	-0.9
Illnesses of siblings: Diabetes	0.6	0.7	1.3	-1.1	-0.2
Loneliness, isolation	0.6	0.8	1.0	1.0	-0.8
Eye problems/disorders: Cataract	0.6	0.7	1.2	-0.5	-1.1
Medication: Blood pressure	0.6	1.2	1.4	1.0	1.2
Age at First Birth	0.5	0.7	0.9	0.9	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.3	-1.1	0.2
Hair Pigment	0.5	14.1	19.9	4.5	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.4	-1.5	0.1
Arm fat percentage (right)	0.5	1.9	2.4	-1.6	1.2
Breastfed as a baby	0.5	0.7	1.0	1.0	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.1	-1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.9	-0.6
Arm fat percentage (left)	0.5	2.0	3.2	-1.8	0.9
Ever had bowel cancer screening	0.5	0.6	1.2	-1.1	-0.1
Smoking status: Current	0.5	0.9	1.6	0.4	1.3
Number of operations (self-reported)	0.5	0.8	1.6	-1.2	-0.1
Schizophrenia (2014)	0.4	0.9	1.7	-1.3	0.3
Triglycerides	0.4	0.7	1.3	1.2	-0.2
Chronotype (morning person)	0.4	0.9	1.6	-0.4	1.3
Number of treatments/medications taken	0.4	0.7	0.9	-0.9	0.8
Angina	0.4	0.5	0.8	0.9	0.3
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.2	0.9
Current tobacco smoking	0.4	0.6	1.1	0.3	1.0
Average weekly fortified wine intake	0.4	0.4	0.5	0.7	-0.6
Relative age voice broke	0.4	0.6	1.0	1.0	-0.4
Medication: Ramipril	0.4	0.5	0.7	-0.8	0.5
Depression (self-reported)	0.4	0.5	0.9	-0.4	0.9
Lung cancer (father)	0.4	0.5	0.6	-0.8	0.7
Pulse wave reflection index	0.4	0.5	0.8	-0.4	0.9
Qualifications: College or University degree	0.4	1.2	2.4	-1.5	0.0
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.9	-0.2
Angina (self-reported)	0.4	0.6	1.0	1.0	0.2
Average weekly red wine intake	0.4	0.6	0.7	-0.7	-0.9
Friendships satisfaction	0.4	0.5	0.8	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	0.5	-1.1
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.9	0.1
Leg fat percentage (left)	0.4	1.4	1.7	-1.3	1.1
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	0.9	-0.5
Schizophrenia (2018)	0.3	0.5	0.8	-0.9	0.6
Crohns Disease (2012)	0.3	0.4	0.9	-0.9	0.1
HbA1C	0.3	0.3	0.6	-0.8	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.8	-0.1
Systolic blood pressure, automated reading	0.3	0.8	1.7	1.3	0.2
Diabetes (father)	0.3	0.4	0.8	-0.9	-0.1
Severe depression (siblings)	0.3	0.4	0.5	-0.7	-0.5
Number of incorrect matches in round	0.3	0.5	0.9	-0.9	-0.3
Past tobacco smoking	0.3	0.6	1.2	1.1	0.1
Worrier / anxious feelings	0.3	0.5	1.0	-0.3	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	1.0	-0.1
Medication: Lansoprazole	0.3	0.4	0.8	-0.0	0.9
Illnesses of mother	0.3	0.4	0.7	-0.1	-0.9
Medication: Paracetamol	0.3	0.5	1.0	1.0	-0.1
Glaucoma (self-reported)	0.3	0.4	0.7	0.8	0.4
Leg fat percentage (right)	0.3	1.1	1.3	-1.1	0.9
Comparative body size at age 10	0.3	0.8	1.5	-0.3	-1.2
Pulse wave peak to peak time	0.3	0.4	0.7	0.9	0.3
Medication: Allopurinol	0.3	0.4	0.6	-0.8	0.3
Number of full sisters	0.3	0.3	0.3	-0.6	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.9	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	0.5	-0.9
Back pain experienced in last month	0.3	0.5	0.6	-0.8	-0.6
Financial situation satisfaction	0.3	0.4	0.6	0.7	-0.6
Ever smoked	0.3	0.5	0.9	-0.9	0.2
Pain experienced in last month	0.3	0.6	0.6	0.8	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.8	-0.3
Heart disease (siblings)	0.3	0.3	0.4	0.5	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-1.0	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.4	-0.5
Alzheimer’s Disease (in father)	0.2	0.3	0.3	-0.6	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.0	-0.8
Neuroticism (2016)	0.2	0.3	0.3	-0.6	0.5
Blood Eosinophil Count	0.2	1.8	2.7	-1.0	-1.6
Blood Platelet Count	0.2	2.6	5.2	2.3	-0.1
Pack years adult smoking proportion	0.2	0.3	0.4	0.4	-0.7
Medication: Atenolol	0.2	0.3	0.4	-0.3	0.7
Body mass index (BMI)	0.2	0.9	1.2	1.1	0.7
Waist circumference	0.2	0.8	1.5	-1.2	-0.1
Father’s age at death	0.2	0.2	0.4	-0.3	0.6
Tense / ‘highly strung’	0.2	0.3	0.4	0.7	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.4	-0.6	-0.5
Number of full brothers	0.2	0.3	0.5	0.7	0.1
Worry too long after embarrassment	0.2	0.3	0.3	-0.6	0.5
Age at first live birth	0.2	0.4	0.4	0.6	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.0	-0.9
Pulse rate, automated reading	0.2	0.7	0.9	0.9	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	-0.4	0.5
Mother’s age at death	0.2	0.2	0.3	-0.6	-0.3
Commuting to job workplace: Public transport	0.2	0.3	0.4	0.4	0.6
Alcohol drinker status: Never	0.2	0.3	0.4	0.6	0.4
Pack years of smoking	0.2	0.3	0.4	0.4	-0.6
Leg fat mass (left)	0.2	0.7	0.9	-0.9	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.2	0.6
Worry (Nagel 2018)	0.1	0.3	0.4	-0.6	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	0.5	0.3
Blood Red Count	0.1	1.1	2.2	-1.5	0.0
Smoking Status	0.1	0.2	0.4	-0.7	-0.1
Neuroticism	0.1	0.3	0.5	-0.3	0.7
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.0	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.4	-0.3
Nervous feelings	0.1	0.2	0.3	-0.5	0.3
Qualifications: None of the above	0.1	0.2	0.2	-0.5	0.3
Neuroticism score	0.1	0.2	0.3	0.1	0.5
Time employed in main current job	0.1	0.1	0.1	0.3	0.2
Happiness	0.1	0.2	0.3	0.5	0.3
Arm fat mass (right)	0.1	0.4	0.7	-0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	0.5
Headache pain in last month	0.1	0.2	0.2	-0.3	-0.5
Gout (self-reported)	0.1	0.2	0.4	-0.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.3	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	0.4
Heart disease (mother)	0.1	0.2	0.3	-0.1	-0.6
Leg fat mass (right)	0.1	0.5	0.7	-0.8	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	-0.2
Illnesses of father: Heart disease	0.1	0.2	0.2	0.3	-0.5
Arm fat mass (left)	0.1	0.5	0.9	-1.0	-0.4
Miserableness	0.1	0.1	0.1	0.3	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.0
Myopia	0.1	0.2	0.2	-0.5	0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.1	-0.4
Crohns Disease (2017)	0.0	0.0	0.0	-0.1	-0.2
Fasting Glucose	0.0	0.0	0.1	0.1	-0.2
Rheumatoid Arthritis	0.0	0.0	0.1	0.1	-0.2
Tanning	0.0	0.5	0.9	-0.4	-0.9
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.2	0.1
Had menopause	0.0	0.0	0.0	-0.0	-0.0
Medication: Amlodipine	0.0	0.1	0.1	-0.2	0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	-0.2	-0.1
Leg pain on walking	0.0	0.0	0.0	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.3	-0.1
Mood swings	0.0	0.0	0.1	0.1	0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.0	0.3
Wears glasses or contact lenses	0.0	0.0	0.1	0.2	-0.1
Medication: Paracetamol	0.0	0.0	0.1	0.2	-0.2
Irritability	0.0	0.0	0.0	-0.0	-0.2

Hub : Genes

UBE4B

Models

Trait associations